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Pesquisa : B01.050.150.900.649.313.988.400.600.037.092 [Categoria DeCS]
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[PMID]:27363338
[Au] Autor:Alba MP; Suarez CF; Varela Y; Patarroyo MA; Bermudez A; Patarroyo ME
[Ad] Endereço:Fundación Instituto de Inmunología de Colombia (FIDIC), Bogotá D. C., Colombia; Universidad del Rosario, Bogotá D. C., Colombia; Universidad de Ciencias Aplicadas y Ambientales (UDCA), Bogotá, Colombia.
[Ti] Título:TCR-contacting residues orientation and HLA-DRß* binding preference determine long-lasting protective immunity against malaria.
[So] Source:Biochem Biophys Res Commun;477(4):654-660, 2016 09 02.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Fully-protective, long-lasting, immunological (FPLLI) memory against Plasmodium falciparum malaria regarding immune protection-inducing protein structures (IMPIPS) vaccinated into monkeys previously challenged and re-challenged 60 days later with a lethal Aotus monkey-adapted P. falciparum strain was found to be associated with preferential high binding capacity to HLA-DRß1* allelic molecules of the major histocompatibility class II (MHC-II), rather than HLA-DRß3*, ß4*, ß5* alleles. Complete PPIIL 3D structure, a longer distance (26.5 Å ± 1.5 Å) between residues perfectly fitting into HLA-DRß1*PBR pockets 1 and 9, a gauche(-) rotamer orientation in p8 TCR-contacting polar residue and a larger volume of polar p2 residues was also found. This data, in association with previously-described p3 and p7 apolar residues having gauche(+) orientation to form a perfect MHC-II-peptide-TCR complex, determines the stereo-electronic and topochemical characteristics associated with FPLLI immunological memory.
[Mh] Termos MeSH primário: Cadeias beta de HLA-DR/química
Cadeias beta de HLA-DR/imunologia
Malária/imunologia
Plasmodium falciparum/imunologia
Receptores de Antígenos de Linfócitos T/química
Receptores de Antígenos de Linfócitos T/imunologia
[Mh] Termos MeSH secundário: Animais
Aotus trivirgatus
Sítios de Ligação
Imunidade Inata/imunologia
Memória Imunológica/imunologia
Ligação Proteica
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (HLA-DR beta-Chains); 0 (Receptors, Antigen, T-Cell)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:171126
[Lr] Data última revisão:
171126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160702
[St] Status:MEDLINE


  2 / 829 MEDLINE  
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[PMID]:25590760
[Au] Autor:Douglas AD; Baldeviano GC; Lucas CM; Lugo-Roman LA; Crosnier C; Bartholdson SJ; Diouf A; Miura K; Lambert LE; Ventocilla JA; Leiva KP; Milne KH; Illingworth JJ; Spencer AJ; Hjerrild KA; Alanine DG; Turner AV; Moorhead JT; Edgel KA; Wu Y; Long CA; Wright GJ; Lescano AG; Draper SJ
[Ad] Endereço:Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK. Electronic address: sandy.douglas@ndm.ox.ac.uk.
[Ti] Título:A PfRH5-based vaccine is efficacious against heterologous strain blood-stage Plasmodium falciparum infection in aotus monkeys.
[So] Source:Cell Host Microbe;17(1):130-9, 2015 Jan 14.
[Is] ISSN:1934-6069
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Antigenic diversity has posed a critical barrier to vaccine development against the pathogenic blood-stage infection of the human malaria parasite Plasmodium falciparum. To date, only strain-specific protection has been reported by trials of such vaccines in nonhuman primates. We recently showed that P. falciparum reticulocyte binding protein homolog 5 (PfRH5), a merozoite adhesin required for erythrocyte invasion, is highly susceptible to vaccine-inducible strain-transcending parasite-neutralizing antibody. In vivo efficacy of PfRH5-based vaccines has not previously been evaluated. Here, we demonstrate that PfRH5-based vaccines can protect Aotus monkeys against a virulent vaccine-heterologous P. falciparum challenge and show that such protection can be achieved by a human-compatible vaccine formulation. Protection was associated with anti-PfRH5 antibody concentration and in vitro parasite-neutralizing activity, supporting the use of this in vitro assay to predict the in vivo efficacy of future vaccine candidates. These data suggest that PfRH5-based vaccines have potential to achieve strain-transcending efficacy in humans.
[Mh] Termos MeSH primário: Proteínas de Transporte/imunologia
Imunidade Heteróloga
Vacinas Antimaláricas/imunologia
Malária/prevenção & controle
[Mh] Termos MeSH secundário: Animais
Anticorpos Neutralizantes/sangue
Anticorpos Antiprotozoários/sangue
Antígenos de Protozoários/imunologia
Aotus trivirgatus
Modelos Animais de Doenças
Feminino
Malária/imunologia
Vacinas Antimaláricas/administração & dosagem
Testes de Neutralização
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, N.I.H., INTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antibodies, Neutralizing); 0 (Antibodies, Protozoan); 0 (Antigens, Protozoan); 0 (Carrier Proteins); 0 (Malaria Vaccines); 0 (RH5 protein, Plasmodium falciparum)
[Em] Mês de entrada:1510
[Cu] Atualização por classe:161019
[Lr] Data última revisão:
161019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150116
[St] Status:MEDLINE


  3 / 829 MEDLINE  
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[PMID]:23960207
[Au] Autor:Charvet CJ; Cahalane DJ; Finlay BL
[Ad] Endereço:Behavioral and Evolutionary Neuroscience Group, Department of Psychology and.
[Ti] Título:Systematic, cross-cortex variation in neuron numbers in rodents and primates.
[So] Source:Cereb Cortex;25(1):147-60, 2015 Jan.
[Is] ISSN:1460-2199
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Uniformity, local variability, and systematic variation in neuron numbers per unit of cortical surface area across species and cortical areas have been claimed to characterize the isocortex. Resolving these claims has been difficult, because species, techniques, and cortical areas vary across studies. We present a stereological assessment of neuron numbers in layers II-IV and V-VI per unit of cortical surface area across the isocortex in rodents (hamster, Mesocricetus auratus; agouti, Dasyprocta azarae; paca, Cuniculus paca) and primates (owl monkey, Aotus trivigratus; tamarin, Saguinus midas; capuchin, Cebus apella); these chosen to vary systematically in cortical size. The contributions of species, cortical areas, and techniques (stereology, "isotropic fractionator") to neuron estimates were assessed. Neurons per unit of cortical surface area increase across the rostro-caudal (RC) axis in primates (varying by a factor of 1.64-2.13 across the rostral and caudal poles) but less in rodents (varying by a factor of 1.15-1.54). Layer II-IV neurons account for most of this variation. When integrated into the context of species variation, and this RC gradient in neuron numbers, conflicts between studies can be accounted for. The RC variation in isocortical neurons in adulthood mirrors the gradients in neurogenesis duration in development.
[Mh] Termos MeSH primário: Neocórtex/citologia
Neurônios/citologia
[Mh] Termos MeSH secundário: Animais
Aotus trivirgatus
Cebus
Contagem de Células
Cuniculidae
Dasyproctidae
Mesocricetus
Neuroglia/citologia
Saguinus
Especificidade da Espécie
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Em] Mês de entrada:1504
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130821
[St] Status:MEDLINE
[do] DOI:10.1093/cercor/bht214


  4 / 829 MEDLINE  
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[PMID]:24860810
[Au] Autor:Aversi-Ferreira RA; Bretas RV; Maior RS; Davaasuren M; Paraguassú-Chaves CA; Nishijo H; Aversi-Ferreira TA
[Ad] Endereço:Department of Anatomy, Howard University College of Medicine, 520 W Street NW, Numa Adams Building, Washington, DC 20059, USA ; Laboratory of Primate Anthropology, Biochemistry, Neurosciences and Behavior, Federal University of Tocantins, NS 15 Avenue, Block 109 Norte, Plano Diretor Norte, 77001-090
[Ti] Título:Morphometric and statistical analysis of the palmaris longus muscle in human and non-human primates.
[So] Source:Biomed Res Int;2014:178906, 2014.
[Is] ISSN:2314-6141
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The palmaris longus is considered a phylogenetic degenerate metacarpophalangeal joint flexor muscle in humans, a small vestigial forearm muscle; it is the most variable muscle in humans, showing variation in position, duplication, slips and could be reverted. It is frequently studied in papers about human anatomical variations in cadavers and in vivo, its variation has importance in medical clinic, surgery, radiological analysis, in studies about high-performance athletes, in genetics and anthropologic studies. Most studies about palmaris longus in humans are associated to frequency or case studies, but comparative anatomy in primates and comparative morphometry were not found in scientific literature. Comparative anatomy associated to morphometry of palmaris longus could explain the degeneration observed in this muscle in two of three of the great apes. Hypothetically, the comparison of the relative length of tendons and belly could indicate the pathway of the degeneration of this muscle, that is, the degeneration could be associated to increased tendon length and decreased belly from more primitive primates to those most derivate, that is, great apes to modern humans. In conclusion, in primates, the tendon of the palmaris longus increase from Lemuriformes to modern humans, that is, from arboreal to terrestrial primates and the muscle became weaker and tending to be missing.
[Mh] Termos MeSH primário: Modelos Anatômicos
Músculo Esquelético/anatomia & histologia
[Mh] Termos MeSH secundário: Animais
Aotus trivirgatus
Atelinae
Brasil
Cadáver
Callithrix
Interpretação Estatística de Dados
Feminino
Antebraço/anatomia & histologia
Seres Humanos
Lemur
Macaca
Masculino
Reprodutibilidade dos Testes
Sensibilidade e Especificidade
Especificidade da Espécie
Strepsirhini
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1501
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140527
[St] Status:MEDLINE
[do] DOI:10.1155/2014/178906


  5 / 829 MEDLINE  
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[PMID]:24582630
[Au] Autor:Bermúdez A; Calderon D; Moreno-Vranich A; Almonacid H; Patarroyo MA; Poloche A; Patarroyo ME
[Ad] Endereço:Fundación Instituto de Inmunología de Colombia (FIDIC), Carrera 50, # 26-20, Bogotá, Colombia; Universidad del Rosario, Calle 14, # 6-25, Bogotá, Colombia.
[Ti] Título:Gauche(+) side-chain orientation as a key factor in the search for an immunogenic peptide mixture leading to a complete fully protective vaccine.
[So] Source:Vaccine;32(18):2117-26, 2014 Apr 11.
[Is] ISSN:1873-2518
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Topological and stereo-electron characteristics are essential in major histocompability class II-peptide-T-cell receptor (MHC-p-TCR) complex formation for inducing an appropriate immune response. Modified high activity binding peptides (mHABPs) were synthesised for complete full protection antimalarial vaccine development producing a large panel of individually fully protection-inducing protein structures (FPIPS) and very high long-lasting antibody-inducing (VHLLAI) mHABPs. Most of those which did not interfere, compete, inhibit or suppress their individual VHLLAI or FPIPS activity contained or displayed a polyproline II-like (PPIIL) structure when mixed. Here we show that amino acid side-chains located in peptide binding region (PBR) positions p3 and p7 displayed specific electron charges and side-chain gauche(+) orientation for interacting with the TCR. Based on the above, and previously described physicochemical principles, non-interfering, long-lasting, full protection-inducing, multi-epitope, multistage, minimal subunit-based chemically synthesised mHABP mixtures can be designed for developing vaccines against diseases scourging humankind, malaria being one of them.
[Mh] Termos MeSH primário: Vacinas Antimaláricas/química
Oligopeptídeos/imunologia
Conformação Proteica
[Mh] Termos MeSH secundário: Adjuvantes Imunológicos/administração & dosagem
Sequência de Aminoácidos
Animais
Anticorpos Antiprotozoários/sangue
Formação de Anticorpos
Aotus trivirgatus
Sítios de Ligação
Cadeias beta de HLA-DR/imunologia
Malária Falciparum/prevenção & controle
Dados de Sequência Molecular
Oligopeptídeos/síntese química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Adjuvants, Immunologic); 0 (Antibodies, Protozoan); 0 (HLA-DR beta-Chains); 0 (Malaria Vaccines); 0 (Oligopeptides)
[Em] Mês de entrada:1408
[Cu] Atualização por classe:140325
[Lr] Data última revisão:
140325
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140304
[St] Status:MEDLINE


  6 / 829 MEDLINE  
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[PMID]:24353298
[Au] Autor:Stepniewska I; Gharbawie OA; Burish MJ; Kaas JH
[Ad] Endereço:Department of Psychology, Vanderbilt University, Nashville, Tennessee.
[Ti] Título:Effects of muscimol inactivations of functional domains in motor, premotor, and posterior parietal cortex on complex movements evoked by electrical stimulation.
[So] Source:J Neurophysiol;111(5):1100-19, 2014 Mar.
[Is] ISSN:1522-1598
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Parietal and frontal cortex are central to controlling forelimb movements. We previously showed that movements such as reach, grasp, and defense can be evoked from primary motor (M1), premotor (PMC), and posterior parietal (PPC) cortex when 500-ms trains of electrical pulses are delivered via microelectrodes. Stimulation sites that evoked a specific movement clustered into domains, which shared a topographic pattern in New World monkeys and prosimian galagos. Matched functional domains in parietal and frontal cortex were preferentially interconnected. We reasoned that matched functional domains form parallel networks involved in specific movements. To test the roles of domains in M1, PMC, and PPC, we systematically inactivated with muscimol domains in one region and determined if functional changes occurred in matching domains in other regions. The most common changes were higher current thresholds for stimulation-evoked movements and shorter, not fully developed, trajectories of movements. Inactivations of an M1 functional domain greatly reduced or abolished movements evoked from the matching domains in PMC or PPC, whereas movements evoked from nonmatching domains remained mostly unaffected. In contrast, inactivating PMC or PPC domains did not consistently abolish the ability to evoke movements from matching M1 domains. However, inactivation of PMC domains suppressed or altered the movements evoked from PPC domains. Thus movement sequences evoked from PMC depend on M1 and movement sequences evoked from PPC depend on both M1 and PMC. Overall, the results support the conclusion that PPC, PMC, and M1 are subdivided into functional domains that are hierarchically related within parallel networks.
[Mh] Termos MeSH primário: Córtex Motor/fisiologia
Movimento/fisiologia
Rede Nervosa/fisiologia
Lobo Parietal/fisiologia
[Mh] Termos MeSH secundário: Animais
Aotus trivirgatus
Estimulação Elétrica
Feminino
Agonistas de Receptores de GABA-A/farmacologia
Galago
Masculino
Córtex Motor/efeitos dos fármacos
Movimento/efeitos dos fármacos
Muscimol/farmacologia
Lobo Parietal/efeitos dos fármacos
Saimiri
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (GABA-A Receptor Agonists); 2763-96-4 (Muscimol)
[Em] Mês de entrada:1410
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:131220
[St] Status:MEDLINE
[do] DOI:10.1152/jn.00491.2013


  7 / 829 MEDLINE  
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[PMID]:23547773
[Au] Autor:Ye Z; Van Dyke K; Rossan RN
[Ad] Endereço:Department of Pharmacology, Institute of Chinese Materia Medica, Academy of Traditional Chinese Medicine, Beijing 100700, China.
[Ti] Título:Effective treatment with a tetrandrine/chloroquine combination for chloroquine-resistant falciparum malaria in Aotus monkeys.
[So] Source:Malar J;12:117, 2013 Apr 02.
[Is] ISSN:1475-2875
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: In vitro evidence indicates that tetrandrine (TT) can potentiate the action of chloroquine 40-fold against choloquine-resistant Plasmodium falciparum. The key question emanating from that study is "would tetrandine and chloroquine be highly effective in a live Aotus monkey model with chloroquine-resistant parasites". This study was designed to closely mimic the pharmacological/anti-malarial activity in man. METHODS: The Vietnam Smith/RE strain of P. falciparum, which is chloroquine-resistant was used in this study. Previous experimental procedures were followed. Panamanian owl monkeys (Aotus) were inoculated with 5×10(6) erythrocytes parasitized with the CQ-resistant strain of P. falciparum. Oral drug treatment was with CQ (20 mg/kg) and/or tetrandrine at 15 mg/Kg, 30 mg/Kg or 60 mg/Kg or 25 mg/Kg depending on experimental conditions. RESULTS AND DISCUSSION: Parasitaemia was cleared rapidly with CQ and TT while CQ treatment alone was ineffective. Recrudescence of malaria occurred after seven days post-infection. However, four animals were treated orally with TT and CQ parasites were cleared. It is likely that monkeys were cured via a combination of both drug and host immune responses. A single Aotus monkey infected with P. falciparum and untreated with drugs, died. No side effects were observed with these drug treatments. CONCLUSIONS: This combination of chloroquine and tetrandrine forms the basis of a new attack on chloroquine-resistant malaria - one based upon inhibition of the basis of chloroquine resistance, the multiple drug resistance pump. Previous studies demonstrated that the parasite MDR pump was found on parasite membranes using 3H azidopine photoaffinity labelling.Since MDR-based choloroquine resistance is induced by chloroquine, the basis of the action of tetrandrine is the following: 1) tetrandrine inhibits the MDR pump by stimulating MDR ATPase which limits the energy of the pump by depletion of parasite ATP, 2) tetrandrine blocks the genetic factor which controls the induction of the pump. Therefore, it appears that the parasite cannot outsmart these mechanisms and produce a new mode of resistance. Only time will tell if this is correct.
[Mh] Termos MeSH primário: Antimaláricos/administração & dosagem
Benzilisoquinolinas/administração & dosagem
Cloroquina/administração & dosagem
Malária Falciparum/tratamento farmacológico
Plasmodium falciparum/isolamento & purificação
[Mh] Termos MeSH secundário: Administração Oral
Animais
Aotus trivirgatus
Modelos Animais de Doenças
Resistência a Medicamentos
Quimioterapia Combinada/métodos
Malária Falciparum/parasitologia
Parasitemia/tratamento farmacológico
Parasitemia/parasitologia
Plasmodium falciparum/efeitos dos fármacos
Recidiva
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antimalarials); 0 (Benzylisoquinolines); 29EX23D5AJ (tetrandrine); 886U3H6UFF (Chloroquine)
[Em] Mês de entrada:1309
[Cu] Atualização por classe:151119
[Lr] Data última revisão:
151119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130404
[St] Status:MEDLINE
[do] DOI:10.1186/1475-2875-12-117


  8 / 829 MEDLINE  
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[PMID]:23142598
[Au] Autor:Patarroyo ME; Moreno-Vranich A; Bermúdez A
[Ad] Endereço:Fundación Instituto de Inmunología de Colombia (FIDIC), Bogotá, Colombia. mepatarr@gmail.com
[Ti] Título:Phi (Φ) and psi (Ψ) angles involved in malarial peptide bonds determine sterile protective immunity.
[So] Source:Biochem Biophys Res Commun;429(1-2):75-80, 2012 Dec 07.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Modified HABP (mHABP) regions interacting with HLA-DRß1(∗) molecules have a more restricted conformation and/or sequence than other mHABPs which do not fit perfectly into their peptide binding regions (PBR) and do not induce an acceptable immune response due to the critical role of their Φ and Ψ torsion angles. These angle's critical role was determined in such highly immunogenic, protection-inducing response against experimental malaria using the conformers (mHABPs) obtained by (1)H-NMR and superimposed into HLA-DRß1(∗)-like Aotus monkey molecules; their phi (Φ) and psi (Ψ) angles were measured and the H-bond formation between these molecules was evaluated. The aforementioned mHABP propensity to assume a regular conformation similar to a left-handed polyproline type II helix (PPII(L)) led to suggesting that favouring these conformations according to their amino acid sequence would lead to high antibody titre production and sterile protective immunity induction against malaria, thereby adding new principles or rules for vaccine development, malaria being one of them.
[Mh] Termos MeSH primário: Vacinas Antimaláricas/química
Vacinas Antimaláricas/imunologia
Malária Falciparum/prevenção & controle
Fragmentos de Peptídeos/química
Fragmentos de Peptídeos/imunologia
Plasmodium falciparum/imunologia
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Animais
Aotus trivirgatus
Cadeias beta de HLA-DR/imunologia
Dados de Sequência Molecular
Ressonância Magnética Nuclear Biomolecular
Peptídeos/química
Peptídeos/imunologia
Estrutura Secundária de Proteína
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (HLA-DR beta-Chains); 0 (Malaria Vaccines); 0 (Peptide Fragments); 0 (Peptides); 25191-13-3 (polyproline)
[Em] Mês de entrada:1304
[Cu] Atualização por classe:121204
[Lr] Data última revisão:
121204
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:121113
[St] Status:MEDLINE


  9 / 829 MEDLINE  
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[PMID]:23142229
[Au] Autor:Patarroyo ME; Bermudez A; Alba MP
[Ad] Endereço:Fundación Instituto de Inmunología de Colombia (FIDIC), Bogotá, Colombia. mepatarr@gmail.com
[Ti] Título:The high immunogenicity induced by modified sporozoites' malarial peptides depends on their phi (Ï•) and psi (ψ) angles.
[So] Source:Biochem Biophys Res Commun;429(1-2):81-6, 2012 Dec 07.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The importance of CSP- and STARP-derived Ï• and ψ dihedral angles in mHABP structure was analysed by (1)H NMR in the search for molecules which can be included as components of a first-line-of-defence Plasmodium falciparum sporozoite multi-epitope vaccine against the most lethal form of human malaria. Most of the aforementioned dihedral angles were left-hand-like polyproline type II (PPII(L)) structures whilst others had right-hand-like α-helix (α(R)), thus allowing mHABPS to fit better into MHCII molecules and thereby form an appropriate pMHCII complex and also establish the H-bonds which stabilise such complex and by this means induce an appropriate immune response. This information has great implications for vaccine development, malaria being one of them.
[Mh] Termos MeSH primário: Antígenos de Protozoários/química
Antígenos de Protozoários/imunologia
Vacinas Antimaláricas/química
Vacinas Antimaláricas/imunologia
Plasmodium falciparum/imunologia
Proteínas de Protozoários/química
Proteínas de Protozoários/imunologia
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Animais
Aotus trivirgatus
Cadeias beta de HLA-DR/química
Cadeias beta de HLA-DR/imunologia
Seres Humanos
Dados de Sequência Molecular
Ressonância Magnética Nuclear Biomolecular
Fragmentos de Peptídeos/química
Fragmentos de Peptídeos/imunologia
Peptídeos/química
Peptídeos/imunologia
Estrutura Secundária de Proteína
Esporozoítos/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antigens, Protozoan); 0 (HLA-DR beta-Chains); 0 (Malaria Vaccines); 0 (Peptide Fragments); 0 (Peptides); 0 (Protozoan Proteins); 0 (STARP antigen, Plasmodium falciparum); 0 (circumsporozoite protein, Protozoan); 25191-13-3 (polyproline)
[Em] Mês de entrada:1304
[Cu] Atualização por classe:121204
[Lr] Data última revisão:
121204
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:121113
[St] Status:MEDLINE


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[PMID]:22713469
[Au] Autor:Moreno-Vranich A; Patarroyo ME
[Ad] Endereço:Fundación Instituto de Inmunología de Colombia, Bogotá, Colombia.
[Ti] Título:Steric-electronic effects in malarial peptides inducing sterile immunity.
[So] Source:Biochem Biophys Res Commun;423(4):857-62, 2012 Jul 13.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Conserved Plasmodium falciparum high activity binding peptides' (HABPs) most relevant proteins involved in malaria parasite invasion are immunologically silent; critical binding residues must therefore be specifically replaced to render them highly immunogenic and protection-inducing. Such changes have a tremendous impact on these peptides' steric-electronic effects, such as modifications to peptide length peptide bonds and electronic orbitals' disposition, to allow a better fit into immune system MHCII molecules and better interaction with the TCR which might account for the final immunological outcome.
[Mh] Termos MeSH primário: Malária/prevenção & controle
Peptídeos/imunologia
Plasmodium falciparum/imunologia
[Mh] Termos MeSH secundário: Animais
Aotus trivirgatus
Elétrons
Sistema Imunitário/imunologia
Imunidade
Malária/imunologia
Peptídeos/química
Conformação Proteica
Receptores de Antígenos de Linfócitos T/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Peptides); 0 (Receptors, Antigen, T-Cell)
[Em] Mês de entrada:1210
[Cu] Atualização por classe:120717
[Lr] Data última revisão:
120717
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120621
[St] Status:MEDLINE
[do] DOI:10.1016/j.bbrc.2012.06.054



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