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[PMID]:28922421
[Au] Autor:Rahman A; Lamberty Y; Schenker E; Cella M; Languille S; Bordet R; Richardson J; Pifferi F; Aujard F
[Ad] Endereço:UMR 7179 Centre National de la Recherche Scientifique, Muséum National d'Histoire Naturelle, Brunoy, France.
[Ti] Título:Effects of acute administration of donepezil or memantine on sleep-deprivation-induced spatial memory deficit in young and aged non-human primate grey mouse lemurs (Microcebus murinus).
[So] Source:PLoS One;12(9):e0184822, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The development of novel therapeutics to prevent cognitive decline of Alzheimer's disease (AD) is facing paramount difficulties since the translational efficacy of rodent models did not resulted in better clinical results. Currently approved treatments, including the acetylcholinesterase inhibitor donepezil (DON) and the N-methyl-D-aspartate antagonist memantine (MEM) provide marginal therapeutic benefits to AD patients. There is an urgent need to develop a predictive animal model that is phylogenetically proximal to humans to achieve better translation. The non-human primate grey mouse lemur (Microcebus murinus) is increasingly used in aging research, but there is no published results related to the impact of known pharmacological treatments on age-related cognitive impairment observed in this primate. In the present study we investigated the effects of DON and MEM on sleep-deprivation (SD)-induced memory impairment in young and aged male mouse lemurs. In particular, spatial memory impairment was evaluated using a circular platform task after 8 h of total SD. Acute single doses of DON or MEM (0.1 and 1mg/kg) or vehicle were administered intraperitoneally 3 h before the cognitive task during the SD procedure. Results indicated that both doses of DON were able to prevent the SD-induced deficits in retrieval of spatial memory as compared to vehicle-treated animals, both in young and aged animals Likewise, MEM show a similar profile at 1 mg/kg but not at 0.1mg/kg. Taken together, these results indicate that two widely used drugs for mitigating cognitive deficits in AD were partially effective in sleep deprived mouse lemurs, which further support the translational potential of this animal model. Our findings demonstrate the utility of this primate model for further testing cognitive enhancing drugs in development for AD or other neuropsychiatric conditions.
[Mh] Termos MeSH primário: Envelhecimento/efeitos dos fármacos
Indanos/farmacologia
Memantina/farmacologia
Transtornos da Memória/tratamento farmacológico
Piperidinas/farmacologia
Privação do Sono/tratamento farmacológico
Memória Espacial/efeitos dos fármacos
[Mh] Termos MeSH secundário: Doença de Alzheimer/complicações
Doença de Alzheimer/tratamento farmacológico
Doença de Alzheimer/fisiopatologia
Animais
Cheirogaleidae
Modelos Animais de Doenças
Masculino
Transtornos da Memória/etiologia
Transtornos da Memória/fisiopatologia
Privação do Sono/complicações
Privação do Sono/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Indans); 0 (Piperidines); 8SSC91326P (donepezil); W8O17SJF3T (Memantine)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170919
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0184822


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[PMID]:28859635
[Au] Autor:Rakotoniaina JH; Kappeler PM; Kaesler E; Hämäläinen AM; Kirschbaum C; Kraus C
[Ad] Endereço:Department of Sociobiology/Anthropology, Georg-August University of Göttingen, Kellnerweg 6, 37077, Göttingen, Germany. josue.h.rakotoniaina@gmail.com.
[Ti] Título:Hair cortisol concentrations correlate negatively with survival in a wild primate population.
[So] Source:BMC Ecol;17(1):30, 2017 Sep 01.
[Is] ISSN:1472-6785
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Glucocorticoid hormones are known to play a key role in mediating a cascade of physiological responses to social and ecological stressors and can therefore influence animals' behaviour and ultimately fitness. Yet, how glucocorticoid levels are associated with reproductive success or survival in a natural setting has received little empirical attention so far. Here, we examined links between survival and levels of glucocorticoid in a small, short-lived primate, the grey mouse lemur (Microcebus murinus), using for the first time an indicator of long-term stress load (hair cortisol concentration). Using a capture-mark-recapture modelling approach, we assessed the effect of stress on survival in a broad context (semi-annual rates), but also under a specific period of high energetic demands during the reproductive season. We further assessed the power of other commonly used health indicators (body condition and parasitism) in predicting survival outcomes relative to the effect of long-term stress. RESULTS: We found that high levels of hair cortisol were associated with reduced survival probabilities both at the semi-annual scale and over the reproductive season. Additionally, very good body condition (measured as scaled mass index) was related to increased survival at the semi-annual scale, but not during the breeding season. In contrast, variation in parasitism failed to predict survival. CONCLUSION: Altogether, our results indicate that long-term increased glucocorticoid levels can be related to survival and hence population dynamics, and suggest differential strength of selection acting on glucocorticoids, body condition, and parasite infection.
[Mh] Termos MeSH primário: Animais Selvagens/metabolismo
Cheirogaleidae/fisiologia
Cabelo/química
Hidrocortisona/análise
[Mh] Termos MeSH secundário: Animais
Fezes/química
Feminino
Cabelo/metabolismo
Hidrocortisona/metabolismo
Masculino
Dinâmica Populacional
Reprodução
Estações do Ano
Comportamento Sexual Animal
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
WI4X0X7BPJ (Hydrocortisone)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171106
[Lr] Data última revisão:
171106
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170902
[St] Status:MEDLINE
[do] DOI:10.1186/s12898-017-0140-1


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[PMID]:28592502
[Au] Autor:Ezran C; Karanewsky CJ; Pendleton JL; Sholtz A; Krasnow MR; Willick J; Razafindrakoto A; Zohdy S; Albertelli MA; Krasnow MA
[Ad] Endereço:Department of Biochemistry.
[Ti] Título:The Mouse Lemur, a Genetic Model Organism for Primate Biology, Behavior, and Health.
[So] Source:Genetics;206(2):651-664, 2017 Jun.
[Is] ISSN:1943-2631
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Systematic genetic studies of a handful of diverse organisms over the past 50 years have transformed our understanding of biology. However, many aspects of primate biology, behavior, and disease are absent or poorly modeled in any of the current genetic model organisms including mice. We surveyed the animal kingdom to find other animals with advantages similar to mice that might better exemplify primate biology, and identified mouse lemurs ( spp.) as the outstanding candidate. Mouse lemurs are prosimian primates, roughly half the genetic distance between mice and humans. They are the smallest, fastest developing, and among the most prolific and abundant primates in the world, distributed throughout the island of Madagascar, many in separate breeding populations due to habitat destruction. Their physiology, behavior, and phylogeny have been studied for decades in laboratory colonies in Europe and in field studies in Malagasy rainforests, and a high quality reference genome sequence has recently been completed. To initiate a classical genetic approach, we developed a deep phenotyping protocol and have screened hundreds of laboratory and wild mouse lemurs for interesting phenotypes and begun mapping the underlying mutations, in collaboration with leading mouse lemur biologists. We also seek to establish a mouse lemur gene "knockout" library by sequencing the genomes of thousands of mouse lemurs to identify null alleles in most genes from the large pool of natural genetic variants. As part of this effort, we have begun a citizen science project in which students across Madagascar explore the remarkable biology around their schools, including longitudinal studies of the local mouse lemurs. We hope this work spawns a new model organism and cultivates a deep genetic understanding of primate biology and health. We also hope it establishes a new and ethical method of genetics that bridges biological, behavioral, medical, and conservation disciplines, while providing an example of how hands-on science education can help transform developing countries.
[Mh] Termos MeSH primário: Comportamento Animal/fisiologia
Cheirogaleidae/genética
Genoma
Primatas/genética
[Mh] Termos MeSH secundário: Animais
Cheirogaleidae/fisiologia
Variação Genética
Seres Humanos
Modelos Genéticos
Filogenia
Primatas/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170714
[Lr] Data última revisão:
170714
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170609
[St] Status:MEDLINE
[do] DOI:10.1534/genetics.116.199448


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[PMID]:28399297
[Au] Autor:Durden LA; Blanco MB; Seabolt MH
[Ad] Endereço:Department of Biology, Georgia Southern University, 4324 Old Register Rd., Statesboro, GA 30458 (ldurden@georgiasouthern.edu; ms09348@georgiasouthern.edu).
[Ti] Título:Two New Species of Sucking Lice (Phthiraptera: Anoplura: Polyplacidae) From Endangered, Hibernating Lemurs (Primates: Cheirogaleidae).
[So] Source:J Med Entomol;54(3):568-575, 2017 May 01.
[Is] ISSN:1938-2928
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Lemurpediculus robbinsi sp. nov. is described from Crossley's dwarf lemur, Cheirogaleus crossleyi A. Grandidier, and Lemurpediculus claytoni sp. nov. is described from Sibree's dwarf lemur, Cheirogaleus sibreei Forsyth Major, from Madagascar. Both sexes of each new louse species are illustrated and distinguished from the two previously known species of Lemurpediculus: L. verruculosus (Ward) and L. petterorum Paulian. With the addition of two new species to the genus, an amended description of Lemurpediculus is provided. The two hosts of the new louse species are morphologically similar, endangered, obligately hibernating lemurs. These two species of lemurs are sometimes sympatric in rainforests in eastern Madagascar. Despite the morphological similarity of the two host species, their lice are morphologically distinct and are easiest to identify based on the shape of the subgenital plate of the female and the shape of the genitalia in the male. Both new species of lice should be considered to be endangered because their hosts are endangered. It is not known if either of the new species of lice are vectors of pathogens or parasites to their hosts.
[Mh] Termos MeSH primário: Anoplura/classificação
Anoplura/fisiologia
Cheirogaleidae
Infestações por Piolhos/veterinária
[Mh] Termos MeSH secundário: Animais
Anoplura/anatomia & histologia
Espécies em Perigo de Extinção
Feminino
Infestações por Piolhos/parasitologia
Madagáscar
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170915
[Lr] Data última revisão:
170915
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170412
[St] Status:MEDLINE
[do] DOI:10.1093/jme/tjw185


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[PMID]:28324014
[Au] Autor:Rotwein P
[Ad] Endereço:Department of Biomedical Sciences, Paul L. Foster School of Medicine, Texas Tech Health University Health Sciences Center, El Paso, Texas 79905.
[Ti] Título:Variation in the Insulin-Like Growth Factor 1 Gene in Primates.
[So] Source:Endocrinology;158(4):804-814, 2017 Apr 01.
[Is] ISSN:1945-7170
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Insulin-like growth factor 1 (IGF1) is a multifunctional peptide that is involved in a wide range of physiological and pathophysiological processes in many animal species, ranging from somatic growth in children to metabolism and tissue regeneration and repair in adults. The IGF1 gene is under multifactorial regulation in the few species in which it has been studied, with major control being exerted by growth hormone through a gene expression pathway involving inducible binding of the STAT5b transcription factor to dispersed enhancer elements. In this study, using resources available in public genomic databases, genes encoding IGF1 have been analyzed in a cohort of six nonhuman primate species representing >60 million years of evolutionary diversification from a common ancestor: chimpanzee, gorilla, macaque, olive baboon, marmoset, and mouse lemur. The IGF1 gene has been well conserved among these primates. Similar to human IGF1, each gene appears to be composed of six exons and five introns, and contains recognizable tandem promoters, each with a unique leader exon. Exon and intron lengths are very similar, and DNA sequence conservation is high, not only in orthologous exons and promoter regions, but also in putative growth hormone-activated STAT5b-binding enhancers that are found in analogous locations in IGF1 intron 3 and in 5' distal intergenic DNA. Taken together, the high level of organizational and nucleotide sequence similarity in the IGF1 gene and locus among these seven species supports the contention that common regulatory paradigms had existed prior to the onset of primate speciation >85 million years ago.
[Mh] Termos MeSH primário: Evolução Molecular
Variação Genética
Fator de Crescimento Insulin-Like I/genética
Regiões Promotoras Genéticas
[Mh] Termos MeSH secundário: Animais
Callithrix/genética
Cheirogaleidae/genética
Bases de Dados Genéticas
Elementos Facilitadores Genéticos
Éxons
Gorilla gorilla/genética
Íntrons
Macaca/genética
Pan troglodytes/genética
Papio anubis/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
67763-96-6 (Insulin-Like Growth Factor I)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170714
[Lr] Data última revisão:
170714
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170322
[St] Status:MEDLINE
[do] DOI:10.1210/en.2016-1920


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[PMID]:28109265
[Au] Autor:Hohenbrink P; Mundy NI; Radespiel U
[Ad] Endereço:Institute of Zoology, University of Veterinary Medicine Hannover, Buenteweg 17, 30559, Hannover, Germany.
[Ti] Título:Population genetics of mouse lemur vomeronasal receptors: current versus past selection and demographic inference.
[So] Source:BMC Evol Biol;17(1):28, 2017 Jan 21.
[Is] ISSN:1471-2148
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: A major effort is underway to use population genetic approaches to identify loci involved in adaptation. One issue that has so far received limited attention is whether loci that show a phylogenetic signal of positive selection in the past also show evidence of ongoing positive selection at the population level. We address this issue using vomeronasal receptors (VRs), a diverse gene family in mammals involved in intraspecific communication and predator detection. In mouse lemurs, we previously demonstrated that both subfamilies of VRs (V1Rs and V2Rs) show a strong signal of directional selection in interspecific analyses. We predicted that ongoing sexual selection and/or co-evolution with predators may lead to current directional or balancing selection on VRs. Here, we re-sequence 17 VRs and perform a suite of selection and demographic analyses in sympatric populations of two species of mouse lemurs (Microcebus murinus and M. ravelobensis) in northwestern Madagascar. RESULTS: M. ravelobensis had consistently higher genetic diversity at VRs than M. murinus. In general, we find little evidence for positive selection, with most loci evolving under purifying selection and one locus even showing evidence of functional loss in M. ravelobensis. However, a few loci in M. ravelobensis show potential evidence of positive selection. Using mismatch distributions and expansion models, we infer a more recent colonisation of the habitat by M. murinus than by M. ravelobensis, which most likely speciated in this region earlier on. CONCLUSIONS: These findings suggest that the analysis of VR variation is useful in inferring demographic and phylogeographic history of mouse lemurs. In conclusion, this study reveals a substantial heterogeneity over time in selection on VR loci, suggesting that VR evolution is episodic.
[Mh] Termos MeSH primário: Adaptação Biológica
Cheirogaleidae/genética
Variação Genética
Filogenia
Seleção Genética
[Mh] Termos MeSH secundário: Animais
Evolução Biológica
Ecossistema
Feminino
Madagáscar
Masculino
Camundongos
Análise de Sequência de DNA
Simpatria
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170901
[Lr] Data última revisão:
170901
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170123
[St] Status:MEDLINE
[do] DOI:10.1186/s12862-017-0874-6


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[PMID]:27848158
[Au] Autor:Blanco MB; Andriantsalohimisantatra AA; Rivoharison TV; Andriambeloson JB
[Ad] Endereço:Duke Lemur Center, 3705 Erwin Road, Durham, NC, 27705, USA. marina.blanco@duke.edu.
[Ti] Título:Evidence of prolonged torpor in Goodman's mouse lemurs at Ankafobe forest, central Madagascar.
[So] Source:Primates;58(1):31-37, 2017 Jan.
[Is] ISSN:1610-7365
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:The small-bodied mouse lemurs of Madagascar (Microcebus) are capable of heterothermy (i.e., torpor or hibernation). The expression of these energy-saving strategies has been physiologically demonstrated in three species: M. berthae, the pygmy mouse lemur (daily torpor), M. murinus, the gray mouse lemur (daily torpor and hibernation), and M. griseorufus, the reddish-gray mouse lemur (daily, prolonged torpor and hibernation). Additional evidence, based on radiotracking and seasonal body mass changes, indicated that mouse lemur capabilities for heterothermy extended to M. lehilahytsara, the Goodman's mouse lemur. In this study, we confirm the use of hibernation in Goodman's mouse lemurs at a new location, a high-plateau forest fragment in Ankafobe, central Madagascar. Our evidence is based on sleeping site monitoring of radiocollared individuals and the retrieval of three mouse lemurs from inside a tree hole, all of which displayed a lethargic state. Though our data are preliminary and scant, we show that hibernation occurs in high-plateau mouse lemurs, and suggest that a buffered environment (i.e., tree holes instead of nests) may be crucial to avoiding potentially extreme ambient temperatures.
[Mh] Termos MeSH primário: Cheirogaleidae/fisiologia
Torpor
[Mh] Termos MeSH secundário: Animais
Feminino
Madagáscar
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1705
[Cu] Atualização por classe:171014
[Lr] Data última revisão:
171014
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161117
[St] Status:MEDLINE
[do] DOI:10.1007/s10329-016-0586-3


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[PMID]:27830334
[Au] Autor:Faherty SL; Campbell CR; Hilbig SA; Yoder AD
[Ad] Endereço:Department of Biology, Duke University, Box 90338, Durham, NC, 27708, USA. sheena.faherty@gmail.com.
[Ti] Título:The effect of body mass and diet composition on torpor patterns in a Malagasy primate (Microcebus murinus).
[So] Source:J Comp Physiol B;187(4):677-688, 2017 May.
[Is] ISSN:1432-136X
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:One of the most obvious physiological changes accompanying seasonal heterothermy in mammals is a fattening stage preceding periods of resource scarcity. This phenomenon reflects the interplay of both diet and physiology. Though the accrual of fat stores is known to be essential for overwintering in some species, the influence of diet on the physiology of torpor is not fully understood. Results from captive studies in heterothermic rodents and marsupials have indicated that when autumn diets are enriched with polyunsaturated fatty acids (PUFAs), animals receiving these diets experience deeper and more frequent torpor bouts than their counterparts receiving a control diet. Our study investigates this potential effect of dietary composition in animals that use daily torpor rather than prolonged torpor (i.e., hibernation). In so doing, we investigate the degree to which dietary effects on torpor are restricted to cold-adapted rodents and marsupials, or are a more general feature of mammalian heterothermy. We examined the effects of a PUFA diet and a control diet on the thermoregulation of one of the few species of primates known to use daily torpor: the grey mouse lemur (Microcebus murinus). Though the results of this study are largely inconclusive regarding the impact of dietary manipulations on torpor frequency and duration, we nonetheless find that the propensity of animals to enter torpor is directly influenced by age and seasonal changes in body mass, and thus reflect important physiological aspects of flexible thermoregulatory responses.
[Mh] Termos MeSH primário: Fenômenos Fisiológicos da Nutrição Animal/fisiologia
Cheirogaleidae/fisiologia
Torpor/fisiologia
[Mh] Termos MeSH secundário: Fatores Etários
Animais
Regulação da Temperatura Corporal
Peso Corporal
Colesterol/metabolismo
Dieta
Ingestão de Alimentos
Ácidos Graxos Insaturados/farmacologia
Masculino
Estações do Ano
Torpor/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fatty Acids, Unsaturated); 97C5T2UQ7J (Cholesterol)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170929
[Lr] Data última revisão:
170929
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161111
[St] Status:MEDLINE
[do] DOI:10.1007/s00360-016-1045-6


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[PMID]:27030164
[Au] Autor:Alleaume C; Mrini ME; Laloy E; Marchal J; Aujard F; Chahory S
[Ad] Endereço:Ecole Nationale Vétérinaire d'Alfort, Unité d'Histologie Embryologie et Anatomie pathologique, Université Paris-Est, Maisons-Alfort, F-94704, France.
[Ti] Título:Scleral and corneal xanthomatous inflammation in a gray mouse lemur (Microcebus murinus).
[So] Source:Vet Ophthalmol;20(2):177-180, 2017 Mar.
[Is] ISSN:1463-5224
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Bilateral multifocal corneal opacity was detected in a 4.5-year-old male captive gray mouse lemur (Microcebus murinus) without other clinical ocular changes. Histopathological examination revealed a severe diffuse granulomatous scleritis and focal keratitis with intralesional cholesterol, consistent with xanthomatous inflammation. This is the first report of xanthomatous inflammation in a gray mouse lemur. This condition may be the result of systemic factors (lipid metabolism disorders) and/or local predisposing factors such as hemorrhage or inflammation. The pathogenesis in this case could not be fully determined. Further studies on lemurs are required for a better understanding of their lipid metabolism, as well as for diagnosing and evaluating the incidence of xanthomatous inflammation in these species.
[Mh] Termos MeSH primário: Cheirogaleidae
Ceratite/veterinária
Esclerite/veterinária
Xantomatose/veterinária
[Mh] Termos MeSH secundário: Animais
Ceratite/patologia
Masculino
Esclerite/patologia
Xantomatose/patologia
[Pt] Tipo de publicação:CASE REPORTS
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170713
[Lr] Data última revisão:
170713
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160401
[St] Status:MEDLINE
[do] DOI:10.1111/vop.12374


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[PMID]:27814506
[Au] Autor:Diehl WE; Lin AE; Grubaugh ND; Carvalho LM; Kim K; Kyawe PP; McCauley SM; Donnard E; Kucukural A; McDonel P; Schaffner SF; Garber M; Rambaut A; Andersen KG; Sabeti PC; Luban J
[Ad] Endereço:Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01605, USA.
[Ti] Título:Ebola Virus Glycoprotein with Increased Infectivity Dominated the 2013-2016 Epidemic.
[So] Source:Cell;167(4):1088-1098.e6, 2016 11 03.
[Is] ISSN:1097-4172
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The magnitude of the 2013-2016 Ebola virus disease (EVD) epidemic enabled an unprecedented number of viral mutations to occur over successive human-to-human transmission events, increasing the probability that adaptation to the human host occurred during the outbreak. We investigated one nonsynonymous mutation, Ebola virus (EBOV) glycoprotein (GP) mutant A82V, for its effect on viral infectivity. This mutation, located at the NPC1-binding site on EBOV GP, occurred early in the 2013-2016 outbreak and rose to high frequency. We found that GP-A82V had heightened ability to infect primate cells, including human dendritic cells. The increased infectivity was restricted to cells that have primate-specific NPC1 sequences at the EBOV interface, suggesting that this mutation was indeed an adaptation to the human host. GP-A82V was associated with increased mortality, consistent with the hypothesis that the heightened intrinsic infectivity of GP-A82V contributed to disease severity during the EVD epidemic.
[Mh] Termos MeSH primário: Ebolavirus/genética
Ebolavirus/patogenicidade
Doença pelo Vírus Ebola/virologia
Proteínas do Envelope Viral/química
Proteínas do Envelope Viral/genética
[Mh] Termos MeSH secundário: África Ocidental/epidemiologia
Substituição de Aminoácidos
Animais
Callithrix
Proteínas de Transporte/química
Proteínas de Transporte/metabolismo
Cheirogaleidae
Citoplasma/virologia
Ebolavirus/fisiologia
Doença pelo Vírus Ebola/epidemiologia
Seres Humanos
Glicoproteínas de Membrana/química
Glicoproteínas de Membrana/metabolismo
Conformação Proteica em alfa-Hélice
Proteínas do Envelope Viral/metabolismo
Vírion/química
Vírion/patogenicidade
Virulência
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (Carrier Proteins); 0 (Membrane Glycoproteins); 0 (NPC1 protein, human); 0 (Viral Envelope Proteins); 0 (envelope glycoprotein, Ebola virus)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161105
[St] Status:MEDLINE



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