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[PMID]:28454694
[Au] Autor:Jawerbaum A; White V
[Ad] Endereço:Laboratory of Reproduction and Metabolism, Center for Pharmacological and Botanical Studies, CEFyBO-CONICET, School of Medicine, University of Buenos Aires, Argentina. Electronic address: a.jawerbaum@gmail.com.
[Ti] Título:Review on intrauterine programming: Consequences in rodent models of mild diabetes and mild fat overfeeding are not mild.
[So] Source:Placenta;52:21-32, 2017 Apr.
[Is] ISSN:1532-3102
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:An adverse intrauterine programming occurs in diabetes and obesity as the consequence of an adverse maternal environment that affects the appropriate fetoplacental development and growth. Experimental models of diabetes and fat overfeeding have provided relevant tools to address putative mechanisms of the adverse intrauterine programming. The current knowledge far extends from the original thoughts of the resulting intrauterine programming of metabolic and cardiovascular diseases to a full range of alterations that affect multiple tissues, organs, and systems that will compromise the long-life health of the offspring. This review examines the postnatal effects of rodent models of mild diabetes and fat overfeeding, identifying the multiple organ derangements in the offspring resulting from mild maternal adverse conditions. In addition, the comparison of experimental models of severe diabetes and fat overfeeding and the crucial role of the placenta are discussed, providing an update of the actual scenario of the putative mechanisms and adverse consequences of maternal metabolic derangements.
[Mh] Termos MeSH primário: Diabetes Mellitus/metabolismo
Desenvolvimento Fetal/fisiologia
Placenta/metabolismo
Efeitos Tardios da Exposição Pré-Natal/metabolismo
[Mh] Termos MeSH secundário: Animais
Diabetes Mellitus/patologia
Modelos Animais de Doenças
Feminino
Placenta/patologia
Gravidez
Efeitos Tardios da Exposição Pré-Natal/patologia
Roedores
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170430
[St] Status:MEDLINE


  2 / 12055 MEDLINE  
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[PMID]:29385162
[Au] Autor:González CR; Muscarsel Isla ML; Vitullo AD
[Ad] Endereço:Centro de Estudios Biomédicos, Biotecnológicos, Ambientales y Diagnóstico- Universidad Maimónides, Buenos Aires, Argentina.
[Ti] Título:The balance between apoptosis and autophagy regulates testis regression and recrudescence in the seasonal-breeding South American plains vizcacha, Lagostomus maximus.
[So] Source:PLoS One;13(1):e0191126, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Mammalian testis undergoes deep changes in their architecture and function during photoregression conditions in seasonal breeders. Particularly, the testicular mechanisms that regulate the transition between the active (functional) and inactive (regression) stage vary between species. The aim of the present study was to analyze the incidence of proliferation, apoptosis and autophagy in the testicular seminiferous ephitelium of a seasonal breeder, Lagostomus maximus, during the annual reproductive cycle. We observed that proliferating spermatogonia increased from the active testis until reaching the maximum peak in the activating testis. During the annual reproductive cycle, the quantity of apoptotic-TUNEL positive spermatogonia and meiotic germ cells was constant and this might be regulated by the members of the BCL2 family. Only in the activating testis, apoptosis of germ cells was almost undetectable. The analysis of the autophagic-related proteins BECN1 and LC3 showed their localization in Leydig cells and the germ cells in the active and activating testis. In the inactive testis, BECN1 and LC3 ceased to be immunolocalized within the seminiferous tubules and the mRNA expression of both regulators decreased. Moreover, the expression of BECN1 and LC3 and also the apoptotic index were up regulated in testicular cultures subjected to nutritional stress. These results suggest a possible interaction between apoptosis and autophagy in the active and activating testis (characterized by high metabolic requirement and nutrient), where autophagy could promote survival over cell death. In the inactive testis, the absence of autophagic-related proteins might explain the massive loss of germ cells, suggesting that autophagy plays new and key role in the alterations of the seminiferous epithelium during photoregression.
[Mh] Termos MeSH primário: Apoptose
Autofagia
Cruzamento
Roedores/fisiologia
Estações do Ano
Testículo/citologia
[Mh] Termos MeSH secundário: Animais
Autofagia/genética
Masculino
Estado Nutricional
Reação em Cadeia da Polimerase em Tempo Real
Túbulos Seminíferos/anatomia & histologia
América do Sul
Estresse Fisiológico
Testículo/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180201
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191126


  3 / 12055 MEDLINE  
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[PMID]:29405683
[Au] Autor:Tsapko NV
[Ti] Título:[Ticks (Acari, ixodidae) of the North Caucasus: Species diversity, host-parasite relationships].
[So] Source:Parazitologiia;51(2):104-20, 2017 Mar-Apr.
[Is] ISSN:0031-1847
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:Biological diversity of ixodid tick fauna of the North Caucasus is analyzed. On the whole, 38 tick species are represented in the fauna of the North Caucasus. Their distribution within the region, biotopic features, and host-parasite relationships of different stages of ontogenesis are considered.
[Mh] Termos MeSH primário: Interações Hospedeiro-Parasita
Ixodidae/fisiologia
Filogenia
Infestações por Carrapato/epidemiologia
Infestações por Carrapato/veterinária
[Mh] Termos MeSH secundário: Animais
Biodiversidade
Aves/classificação
Aves/parasitologia
Carnívoros/classificação
Carnívoros/parasitologia
Ouriços-Cacheiros/classificação
Ouriços-Cacheiros/parasitologia
Especificidade de Hospedeiro
Seres Humanos
Ixodidae/classificação
Lagomorpha/classificação
Lagomorpha/parasitologia
Roedores/classificação
Roedores/parasitologia
Ruminantes/classificação
Ruminantes/parasitologia
Federação Russa/epidemiologia
Especificidade da Espécie
Infestações por Carrapato/parasitologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180207
[St] Status:MEDLINE


  4 / 12055 MEDLINE  
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[PMID]:29323844
[Au] Autor:Pukhovskaya NM; Morozova OV; Belozerova NB; Bakhmetyeva SV; Vysochina NP; Zdanovskaya NI; Ivanov LI
[Ti] Título:Comparative analysis of genomes of tick-borne encephalitis virus strains isolated from mosquitoes and ticks.
[So] Source:Vopr Virusol;62(1):30-5, 2017.
[Is] ISSN:0507-4088
[Cp] País de publicação:Russia (Federation)
[La] Idioma:eng
[Ab] Resumo:The tick-borne encephalitis virus (TBEV) strain Lazo MP36 was isolated from the pool of mosquitoes Aedes vexans collected in Lazo region of Khabarovsk territory in August 2014. Phylogenetic analysis of the strain Lazo MP36 complete genome (GenBank accession number KT001073) revealed its correspondence to the TBEV Far Eastern subtype and differences from the following strains: 1) from ticks Ixodes persulcatus P. Schulze, 1930 [vaccine strain 205 (JX498939) and strains Khekhtzir 1230 (KF880805), Chichagovka (KP844724), Birobidzhan 1354 (KF880805) isolated in 2012-2013]; 2) from mosquitoes [strain Malyshevo (KJ744034) isolated in 1978 from Aedes vexans nipponii in Khabarovsk territory; strain Sakhalin 6-11 isolated from the pool of mosquitoes in 2011 (KF826916)]; 3) from human brain [vaccine strain Sofjin (JN229223), Glubinnoe/2004(DQ862460). Kavalerovo (DQ862460), Svetlogorie (DQ862460)]. The fusion peptide necessary for flavivirus entry to cells of the three TBEV strains isolated from mosquitoes (Lazo MP36, Malyshevo and Sakhalin 6-11) has the canonical structure 98-DRGWGNHCGLFGKGSI-113 for the tick-borne flaviviruses. Amino acid transition H104G typical for the mosquito-borne flaviviruses was not found. Structures of 5'- and 3'-untranslated (UTR) regions of the TBEV strains from mosquitoes were 85-98% homologous to the TBEV strains of all subtypes without recombination with mosquito-borne flaviviruses found in the Far East of Russia. Secondary structures of 5'- and 3'-UTR as well as cyclization sequences (CS) of types a and B are highly homologous for all TBEV isolates independently of the biological hosts and vectors. similarity of the genomes of the TBEV isolates from mosquitoes, ticks and patients as well as pathogenicity of the isolates for new-borne laboratory mice and tissue cultures might suggest a possible role of mosquitoes in the TBEV circulation in natural foci as an accidental or additional virus carrier.
[Mh] Termos MeSH primário: Aedes/virologia
Vírus da Encefalite Transmitidos por Carrapatos/genética
Encefalite Transmitida por Carrapatos/epidemiologia
Genoma Viral
Ixodes/virologia
RNA Viral/genética
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Animais
Animais Recém-Nascidos
Vetores de Doenças
Cães
Vírus da Encefalite Transmitidos por Carrapatos/classificação
Vírus da Encefalite Transmitidos por Carrapatos/isolamento & purificação
Encefalite Transmitida por Carrapatos/transmissão
Encefalite Transmitida por Carrapatos/virologia
Extremo Oriente/epidemiologia
Genótipo
Seres Humanos
Camundongos
Camundongos Endogâmicos ICR
Conformação de Ácido Nucleico
Filogenia
RNA Viral/química
RNA Viral/isolamento & purificação
Roedores/virologia
Alinhamento de Sequência
Homologia de Sequência de Aminoácidos
Sibéria/epidemiologia
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (RNA, Viral)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180208
[Lr] Data última revisão:
180208
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180112
[St] Status:MEDLINE


  5 / 12055 MEDLINE  
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[PMID]:29227066
[Au] Autor:Fujimoto H
[Ti] Título:Anatomical Comparison between Rodent and Avian Circuits for Vocal Communication.
[So] Source:Fukuoka Igaku Zasshi;107(9):169-76, 2016 09.
[Is] ISSN:0016-254X
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Mh] Termos MeSH primário: Encéfalo/anatomia & histologia
Vocalização Animal
[Mh] Termos MeSH secundário: Animais
Aves
Seres Humanos
Aprendizagem
Roedores
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180208
[Lr] Data última revisão:
180208
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171212
[St] Status:MEDLINE


  6 / 12055 MEDLINE  
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[PMID]:29368484
[Au] Autor:Guja I; Lapinski S; Migdal L; Palka S; Zabek T; Sergina SN
[Ti] Título:[Microsatellite markers polymorphism in the breeding nutria (Myocastor coypus) population in Poland].
[So] Source:Genetika;52(5):590-4, 2016 May.
[Is] ISSN:0016-6758
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:The aim of the research was to establish a microsatellite panel to determine the genetic diversity within the breeding nutria population in Poland. In the study, 92 animals representing six color forms were used. Ten fluorescently labeled microsatellite markers were investigated by multicolored capillary electrophoresis. All the microsatellites were polymorphic. The average heterozygosity observed among the population was 41%. The mean number of alleles per locus was 9.2. The average heterozygosity observed in the whole population was lower than expected. This implies that the nutria population deviates from the Hardy­Weinberg equilibrium. Low M values (from 0.078 to 0.545) of the Garza­Williamson index reveal a reduction of genetic variation in the investigated population and suggest that the breeding nutria population is remnant.
[Mh] Termos MeSH primário: Repetições de Microssatélites
Polimorfismo Genético
Roedores/genética
[Mh] Termos MeSH secundário: Animais
Cruzamento
Genética Populacional
Polônia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180205
[Lr] Data última revisão:
180205
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180126
[St] Status:MEDLINE


  7 / 12055 MEDLINE  
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Alves, Leucio Câmara
Texto completo
[PMID]:28468666
[Au] Autor:Silva JCR; Ferreira F; Dias RA; Ajzenberg D; Marvulo MFV; Magalhães FJR; Filho CDFL; Oliveira S; Soares HS; Feitosa TF; Aizawa J; Alves LC; Mota RA; Dubey JP; Gennari SM; Pena HFJ
[Ad] Endereço:Departamento de Medicina Veterinária, Universidade Federal Rural de Pernambuco, Rua Dom Manoel de Medeiros, s/n, Dois Irmãos, Recife, PE, 52171-900, Brazil.
[Ti] Título:Cat-rodent Toxoplasma gondii Type II-variant circulation and limited genetic diversity on the Island of Fernando de Noronha, Brazil.
[So] Source:Parasit Vectors;10(1):220, 2017 May 03.
[Is] ISSN:1756-3305
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: In Brazil, studies on animals and humans in mainland areas have shown that most strains of Toxoplasma gondii are pathogenic to mice and exhibit great genetic variability. RESULTS: In this study, using a set of 11 PCR-RFLP and 15 microsatellite markers, we isolated and genetically characterised T. gondii strains from one cat and three rats on Fernando de Noronha Island. The cat had antibodies to T. gondii, which were revealed using a modified agglutination test (MAT, cut-off 1:25) and the seroprevalence among the 46 rodents was 15.2%. Viable T. gondii was isolated from one cat (TgCatBrFN1), two brown rats (TgRatnoBrFN1 and TgRatnoBrFN2) and one black rat (TgRatraBrFN1). Unlike the strains from mainland Brazil, these isolates were not pathogenic to outbred mice. The genotypes of these strains were compared with strains previously isolated on the island and in mainland Brazil. The analysis based on microsatellite data showed a limited genetic diversity of T. gondii on Fernando de Noronha Island with the majority of strains clustered into the following three groups: type II, III, and Caribbean 1. CONCLUSIONS: There was little variation among strains within the same group, suggesting that the majority of strains circulating on Fernando de Noronha are derived from only a few strains that were recently introduced to the island, likely from imported cats. Except for the strain belonging to the Caribbean 1 group that originates from northeast Brazil, there was little evidence that strains from the other groups were introduced to Fernando de Noronha via mainland Brazil.
[Mh] Termos MeSH primário: Doenças do Gato/parasitologia
Variação Genética
Doenças dos Roedores/parasitologia
Toxoplasma/genética
Toxoplasma/isolamento & purificação
Toxoplasmose Animal/parasitologia
[Mh] Termos MeSH secundário: Testes de Aglutinação
Animais
Animais Selvagens
Anticorpos Antiprotozoários/sangue
Brasil/epidemiologia
Gatos/parasitologia
Genótipo
Seres Humanos
Ilhas
Camundongos
Repetições de Microssatélites
Reação em Cadeia da Polimerase/veterinária
Polimorfismo de Fragmento de Restrição
Ratos
Roedores/parasitologia
Estudos Soroepidemiológicos
Toxoplasma/imunologia
Toxoplasma/patogenicidade
Toxoplasmose Animal/epidemiologia
Toxoplasmose Animal/imunologia
Toxoplasmose Animal/transmissão
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Protozoan)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180205
[Lr] Data última revisão:
180205
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1186/s13071-017-2150-4


  8 / 12055 MEDLINE  
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[PMID]:29281618
[Au] Autor:Ashida G; Tollin DJ; Kretzberg J
[Ad] Endereço:Cluster of Excellence "Hearing4all", Department of Neuroscience, University of Oldenburg, Oldenburg, Germany.
[Ti] Título:Physiological models of the lateral superior olive.
[So] Source:PLoS Comput Biol;13(12):e1005903, 2017 12.
[Is] ISSN:1553-7358
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In computational biology, modeling is a fundamental tool for formulating, analyzing and predicting complex phenomena. Most neuron models, however, are designed to reproduce certain small sets of empirical data. Hence their outcome is usually not compatible or comparable with other models or datasets, making it unclear how widely applicable such models are. In this study, we investigate these aspects of modeling, namely credibility and generalizability, with a specific focus on auditory neurons involved in the localization of sound sources. The primary cues for binaural sound localization are comprised of interaural time and level differences (ITD/ILD), which are the timing and intensity differences of the sound waves arriving at the two ears. The lateral superior olive (LSO) in the auditory brainstem is one of the locations where such acoustic information is first computed. An LSO neuron receives temporally structured excitatory and inhibitory synaptic inputs that are driven by ipsi- and contralateral sound stimuli, respectively, and changes its spike rate according to binaural acoustic differences. Here we examine seven contemporary models of LSO neurons with different levels of biophysical complexity, from predominantly functional ones ('shot-noise' models) to those with more detailed physiological components (variations of integrate-and-fire and Hodgkin-Huxley-type). These models, calibrated to reproduce known monaural and binaural characteristics of LSO, generate largely similar results to each other in simulating ITD and ILD coding. Our comparisons of physiological detail, computational efficiency, predictive performances, and further expandability of the models demonstrate (1) that the simplistic, functional LSO models are suitable for applications where low computational costs and mathematical transparency are needed, (2) that more complex models with detailed membrane potential dynamics are necessary for simulation studies where sub-neuronal nonlinear processes play important roles, and (3) that, for general purposes, intermediate models might be a reasonable compromise between simplicity and biological plausibility.
[Mh] Termos MeSH primário: Modelos Neurológicos
Complexo Olivar Superior/fisiologia
[Mh] Termos MeSH secundário: Estimulação Acústica
Animais
Gatos
Biologia Computacional
Simulação por Computador
Fenômenos Eletrofisiológicos
Neurônios/fisiologia
Roedores
Localização de Som/fisiologia
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180123
[Lr] Data última revisão:
180123
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171228
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pcbi.1005903


  9 / 12055 MEDLINE  
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[PMID]:29283518
[Au] Autor:Ivanova VV; Milto IV; Sukhodolo IV; Serebryakova ON; Buzenkova AV
[Ti] Título:Digestive and Nondigestive Functions of Rodents' Salivary Glands.
[So] Source:Usp Fiziol Nauk;48(1):66-79, 2017 Jan-Mar.
[Is] ISSN:0301-1798
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:Major salivary glands play a role not only in digestion, but also in regulation of other functions in rodents. In this review, we analyzed and summarized the data about the rodents' parotid, submandibular and sublingual salivary glands functions, which is not limited to the production of saliva and action of its hydrolytic enzymes on food in the oral cavity. In recent decades significantly expanded understanding of major salivary glands nondigestive functions. They are involved in excretion of metabolic products, maintaining fluid and electrolyte balance. Special attention has been paid to the characteristics of specific (parotin, sialorphin, etc.) and nonspecific (epidermal growth factor, nerve growth factor, kallikrein, etc.) active substances of the major salivary glands and their involvement in wound healing, mineral metabolism, regulation of hematopoiesis and immunity system. Summarized and analyzed major salivary glands endocrine function in the organs and systems. Available literature data suggest: the structure of the major salivary glands, as well as the synthesis and secretion of a number of biologically active substances are controlled by sex hormones. In turn, these biologically active factors of the salivary glands, as epidermal growth factor, and parotin, sialorphin, whose expression is regulated by androgens, have an impact on the morphological and functional state of the gonads. Thus, major salivary glands operate a wide range of functions and involved in the regulation of sexual behavior of reproductive function and maintaining homeostasis in the body.
[Mh] Termos MeSH primário: Glândula Parótida/fisiologia
Roedores/fisiologia
Proteínas e Peptídeos Salivares/metabolismo
Glândula Sublingual/fisiologia
Glândula Submandibular/fisiologia
[Mh] Termos MeSH secundário: Animais
Fator de Crescimento Epidérmico/genética
Fator de Crescimento Epidérmico/metabolismo
Regulação da Expressão Gênica
Hormônios Esteroides Gonadais/genética
Hormônios Esteroides Gonadais/metabolismo
Hematopoese/fisiologia
Imunidade Inata/efeitos dos fármacos
Calicreínas/genética
Calicreínas/metabolismo
Fator de Crescimento Neural/genética
Fator de Crescimento Neural/metabolismo
Saliva/química
Saliva/fisiologia
Proteínas e Peptídeos Salivares/genética
Proteínas e Peptídeos Salivares/farmacologia
Equilíbrio Hidroeletrolítico/fisiologia
Cicatrização/efeitos dos fármacos
Cicatrização/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Gonadal Steroid Hormones); 0 (Salivary Proteins and Peptides); 62229-50-9 (Epidermal Growth Factor); 9061-61-4 (Nerve Growth Factor); EC 3.4.21.- (Kallikreins)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180116
[Lr] Data última revisão:
180116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171229
[St] Status:MEDLINE


  10 / 12055 MEDLINE  
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[PMID]:29206840
[Au] Autor:Campbell RD; Rosell F; Newman C; Macdonald DW
[Ad] Endereço:University College of Southeast Norway, Department of Natural Sciences and Environmental Health, Bø i Telemark, Norway.
[Ti] Título:Age-related changes in somatic condition and reproduction in the Eurasian beaver: Resource history influences onset of reproductive senescence.
[So] Source:PLoS One;12(12):e0187484, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Using 15 years of data from a stable population of wild Eurasian beavers (Castor fiber), we examine how annual and lifetime access to food resources affect individual age-related changes in reproduction and somatic condition. We found an age-related decline in annual maternal reproductive output, after a peak at age 5-6. Rainfall, an established negative proxy of annual resource availability for beavers, was consistently associated with lower reproductive output for females of all ages. In contrast, breeding territory quality, as a measure of local resource history over reproductive lifetimes, caused differences in individual patterns of reproductive senescence; animals from lower quality territories senesced when younger. Litter size was unrelated to maternal age, although adult body weight increased with age. In terms of resource effects, in poorer years but not in better years, older mothers produced larger offspring than did younger mothers, giving support to the constraint theory. Overall, our findings exemplify state-dependent life-history strategies, supporting an effect of resources on reproductive senescence, where cumulative differences in resource access, and not just reproductive strategy, mediate long-term reproductive trade-offs, consistent with the disposable soma and reproductive restraint theories. We propose that flexible life-history schedules could play a role in the dynamics of populations exhibiting reproductive skew, with earlier breeding opportunities leading to an earlier senescence schedule through resource dependent mechanisms.
[Mh] Termos MeSH primário: Envelhecimento/fisiologia
Roedores/fisiologia
[Mh] Termos MeSH secundário: Animais
Feminino
Tamanho da Ninhada de Vivíparos
Masculino
Gravidez
Reprodução
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171229
[Lr] Data última revisão:
171229
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171206
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0187484



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