Base de dados : MEDLINE
Pesquisa : B01.050.150.900.649.313.992.600 [Categoria DeCS]
Referências encontradas : 413 [refinar]
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  1 / 413 MEDLINE  
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[PMID]:29364114
[Au] Autor:Beltrán-Sánchez H; Finch C
[Ad] Endereço:Department of Community Health Sciences and California Center for Population Research, The University of California Los Angeles, Los Angeles, United States.
[Ti] Título:Age is just a number.
[So] Source:Elife;7, 2018 01 24.
[Is] ISSN:2050-084X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The naked mole rat defies the Gompertz law and shows no sign of increased mortality risk as it gets older.
[Mh] Termos MeSH primário: Ratos-Toupeira
[Mh] Termos MeSH secundário: Animais
[Pt] Tipo de publicação:JOURNAL ARTICLE; COMMENT
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180202
[Lr] Data última revisão:
180202
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180125
[St] Status:MEDLINE


  2 / 413 MEDLINE  
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[PMID]:29281661
[Au] Autor:Kurz S; Thieme R; Amberg R; Groth M; Jahnke HG; Pieroh P; Horn LC; Kolb M; Huse K; Platzer M; Volke D; Dehghani F; Buzdin A; Engel K; Robitzki A; Hoffmann R; Gockel I; Birkenmeier G
[Ad] Endereço:Institute of Biochemistry, University of Leipzig, Medical Faculty, Leipzig, Germany.
[Ti] Título:The anti-tumorigenic activity of A2M-A lesson from the naked mole-rat.
[So] Source:PLoS One;12(12):e0189514, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Cancer resistance is a major cause for longevity of the naked mole-rat. Recent liver transcriptome analysis in this animal compared to wild-derived mice revealed higher expression of alpha2-macroglobulin (A2M) and cell adhesion molecules, which contribute to the naked mole-rat's cancer resistance. Notably, A2M is known to dramatically decrease with age in humans. We hypothesize that this might facilitate tumour development. Here we found that A2M modulates tumour cell adhesion, migration and growth by inhibition of tumour promoting signalling pathways, e.g. PI3K / AKT, SMAD and up-regulated PTEN via down-regulation of miR-21, in vitro and in tumour xenografts. A2M increases the expression of CD29 and CD44 but did not evoke EMT. Transcriptome analysis of A2M-treated tumour cells, xenografts and mouse liver demonstrated a multifaceted regulation of tumour promoting signalling pathways indicating a less tumorigenic environment mediated by A2M. By virtue of these multiple actions the naturally occurring A2M has strong potential as a novel therapeutic agent.
[Mh] Termos MeSH primário: Neoplasias/prevenção & controle
alfa 2-Macroglobulinas Associadas à Gravidez/fisiologia
[Mh] Termos MeSH secundário: Animais
Xenoenxertos
Seres Humanos
Modelos Animais
Ratos-Toupeira
Neoplasias/patologia
PTEN Fosfo-Hidrolase/metabolismo
Fosfatidilinositol 3-Quinases/metabolismo
Proteínas Proto-Oncogênicas c-akt/metabolismo
Proteínas Smad/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Pregnancy-Associated alpha 2-Macroglobulins); 0 (Smad Proteins); EC 2.7.1.- (Phosphatidylinositol 3-Kinases); EC 2.7.11.1 (Proto-Oncogene Proteins c-akt); EC 3.1.3.67 (PTEN Phosphohydrolase)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180129
[Lr] Data última revisão:
180129
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171228
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189514


  3 / 413 MEDLINE  
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[PMID]:28425035
[Au] Autor:Junker K; Lutermann H; Mutafchiev Y
[Ad] Endereço:Parasites, Vectors and Vector-Borne Diseases, ARC-Onderstepoort Veterinary Institute, Private Bag X05, Onderstepoort, 0110, South Africa. junkerk@arc.agric.za.
[Ti] Título:A new ascaridid nematode, Mammalakis zambiensis n. sp. (Heterakoidea: Kiwinematidae), from the mole rat Fukomys anselli (Burda, Zima, Scharff, Macholán & Kawalika) (Rodentia: Bathyergidae) in Zambia.
[So] Source:Syst Parasitol;94(5):557-566, 2017 Jun.
[Is] ISSN:1573-5192
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Mammalakis zambiensis n. sp. is described from the large intestine and caecum of Fukomys anselli (Burda, Zima, Scharff, Macholán & Kawalika), a bathyergid rodent endemic to Zambia. Morphological data for comparison with its three congeners, M. macrospiculum (Ortlepp, 1939), M. spalacis (Marcu, 1930) and M. spalaxi (Kozlov & Jangolenko, 1962) are provided. Based on studies of the type-material, observations of hitherto undescribed morphological characters of M. macrospiculum, a parasite of Bathyergus suillus (Schreber) (Hystricomorpha: Bathyergidae) in South Africa, are presented. To date, the generic diagnosis of Mammalakis Inglis, 1991 is based largely on characters of its type-species, M. macrospiculum. In having three rounded lips, not set-off from the body, a stout oesophagus with a flask-shaped posterior bulb, lateral alae that broaden on the level of the precloacal sucker and cloaca, and mature eggs with a smooth shell, M. zambienis n. sp. corresponds to the characters of the genus. However, the presence of lips with anterior flanges that were observed in M. zambiensis n. sp., and also for the first time in M. macrospiculum, are in contrast with the current diagnosis of Mammalakis. Further studies will be needed to determine if an amendment of the generic diagnosis is indicated.
[Mh] Termos MeSH primário: Ratos-Toupeira/parasitologia
Nematoides/classificação
[Mh] Termos MeSH secundário: Animais
Ceco/parasitologia
Intestino Grosso/parasitologia
Nematoides/anatomia & histologia
Especificidade da Espécie
Zâmbia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171101
[Lr] Data última revisão:
171101
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170421
[St] Status:MEDLINE
[do] DOI:10.1007/s11230-017-9721-9


  4 / 413 MEDLINE  
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[PMID]:28409694
[Au] Autor:Gür FM; Timurkaan S; Yalcin MH; Girgin A; Gençer Tarakçi B
[Ad] Endereço:a Department of Histology and Embryology , School of Medicine, Ömer Halisdemir University , Nigde.
[Ti] Título:Immunohistochemical localization of irisin in mole rats (Spalax leucodon).
[So] Source:Biotech Histochem;92(4):245-251, 2017.
[Is] ISSN:1473-7760
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Irisin was first identified in skeletal muscle cells. It is an exercise protein that is secreted into the circulation; it causes conversion of white adipose tissue to brown adipose tissue. We investigated irisin immunoreactivity in mole rat (Spalax leucodon) tissues. We examined cerebellum, pituitary, heart, liver, pancreas, spleen, uterus, kidney and striated muscle in female adult mole rats. Tissues were processed, embedded in paraffin, sectioned at 5 µm and stained immunohistochemically for irisin. Irisin immunostaining was detected in the cytoplasm of stained cells; the cytoplasm of Purkinje cells was unstained. We found that irisin may be synthesized in many tissues. The function of locally synthesized irisin currently is unknown.
[Mh] Termos MeSH primário: Estruturas Animais/metabolismo
Fibronectinas/metabolismo
Imuno-Histoquímica
Ratos-Toupeira
[Mh] Termos MeSH secundário: Animais
Feminino
Fibronectinas/análise
Músculo Esquelético/metabolismo
Células de Purkinje/metabolismo
Coloração e Rotulagem
Distribuição Tecidual
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (FNDC5 protein, rat); 0 (Fibronectins)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170415
[St] Status:MEDLINE
[do] DOI:10.1080/10520295.2017.1303194


  5 / 413 MEDLINE  
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[PMID]:28370359
[Au] Autor:Sahd L; Pereira DL; Bennett NC; Kotzé SH
[Ad] Endereço:Division of Anatomy and Histology, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, 8000, South Africa.
[Ti] Título:Comparative gastrointestinal morphology of Tachyoryctes splendens (Rüppell, 1835) and Heliophobius emini, (Noack, 1894) two species of East African mole-rats.
[So] Source:J Morphol;278(6):780-790, 2017 Jun.
[Is] ISSN:1097-4687
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Tachyoryctes splendens (Northeast African mole-rat) and Heliophobius emini (Emin's mole-rat) are two African mole-rats that represent separate allopatric rodent families namely Spalacidae and Bathyergidae respectively. While these species consume a similar diet of underground plant storage organs such as roots and tubers, T. splendens has been reported to additionally consume small amounts of aerial foliage. This study aims to provide detailed gross morphological and histological morphometric analyses of the gastrointestinal tract (GIT) of these two subterranean species. The formalin fixed gastrointestinal tracts of T. splendens (n = 9) and H. emini (n = 6) were photographed, weighed and measured. The length and basal surface areas were calculated for each anatomically distinct region. Representative histological samples were prepared and stained using Hematoxylin and Eosin. Microscopic luminal measurements were used to calculate a surface enlargement factor and the luminal surface area of each region. Tachyoryctes splendens had a large double chambered hemi-glandular stomach with a macroscopically visible transition from keratinized stratified squamous epithelium to glandular epithelium. The cecum was large and the luminal surface revealed a single spiral fold. The ascending colon of T. splendens was arranged in a spiral, with two centripetal and two centrifugal windings. The descending colon was arranged in a single parallel loop, similar to H. emini. A narrow colonic groove was accompanied by V-shaped folds on either side. Heliophobius emini had a simple glandular stomach, a large, haustrated cecum that displayed a cecal appendix and the descending colon was arranged in a single parallel loop. The internal aspect of the colon revealed a wide colonic groove extending from the ceco-colic junction to distal colon. As both species originate from a similar geographical region and ingest very similar diets, it is likely that the differences in the GIT morphology are attributed to phylogeny as the species represent two different families of mole-rats.
[Mh] Termos MeSH primário: Trato Gastrointestinal/anatomia & histologia
Ratos-Toupeira/anatomia & histologia
[Mh] Termos MeSH secundário: África Oriental
Animais
Ceco/anatomia & histologia
Colo/anatomia & histologia
Estatística como Assunto
Estômago/anatomia & histologia
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170404
[St] Status:MEDLINE
[do] DOI:10.1002/jmor.20672


  6 / 413 MEDLINE  
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[PMID]:28104824
[Au] Autor:Voigt C; Bennett NC
[Ad] Endereço:Department of Zoology and EntomologyUniversity of Pretoria, Pretoria, South Africa cvoigt@zoology.up.ac.za.
[Ti] Título: mRNA expression in the brain of cooperatively breeding female Damaraland mole-rats.
[So] Source:Reproduction;153(4):453-460, 2017 Apr.
[Is] ISSN:1741-7899
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The Damaraland mole-rat ( ) is a eusocial, subterranean rodent, in which breeding is limited to a single reproductive pair within each colony. Non-reproductive females, while in the confines of the colony, exhibit socially induced infertility. Anovulation is thought to be caused by a disruption in the normal gonadotropin-releasing hormone (GNRH) secretion from the hypothalamus. To assess whether social suppression is associated with altered mRNA expression in the brain, we investigated the distribution and gene expression levels by means of hybridization in female breeders and non-breeders from field captured colonies of the Damaraland mole-rat. We found expression of mRNA as a loose network in several forebrain areas of female Damaraland mole-rats with the majority of labelling in the preoptic and anterior hypothalamus. The distribution matched previous findings using immunocytochemistry in this and other social mole-rat species. Quantification of the hybridisation signal revealed no difference between breeding and non-breeding females in the average optical density of the hybridization signal and the size of the total area covered by mRNA. However, analysis along the rostro-caudal axis revealed significantly elevated mRNA expression in the rostral preoptic region of breeders compared to non-breeders, whereas the latter had increased mRNA expression at the caudal level of the anterior hypothalamus. This study indicates that social suppression affects the expression of mRNA in female Damaraland mole-rats. Furthermore, differential regulation occurs within different neuron subpopulations.
[Mh] Termos MeSH primário: Encéfalo/metabolismo
Hormônio Liberador de Gonadotropina/metabolismo
Hipotálamo/metabolismo
RNA Mensageiro/metabolismo
Reprodução/genética
Meio Social
[Mh] Termos MeSH secundário: Animais
Cruzamento
Feminino
Hormônio Liberador de Gonadotropina/genética
Hibridização In Situ
Ratos-Toupeira
RNA Mensageiro/genética
Ratos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (RNA, Messenger); 33515-09-2 (Gonadotropin-Releasing Hormone)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170121
[St] Status:MEDLINE
[do] DOI:10.1530/REP-16-0471


  7 / 413 MEDLINE  
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[PMID]:28072840
[Au] Autor:Haupt M; Bennett NC; Oosthuizen MK
[Ad] Endereço:Department of Zoology & Entomology, University of Pretoria, Pretoria, South Africa.
[Ti] Título:Locomotor Activity and Body Temperature Patterns over a Temperature Gradient in the Highveld Mole-Rat (Cryptomys hottentotus pretoriae).
[So] Source:PLoS One;12(1):e0169644, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:African mole-rats are strictly subterranean mammals that live in extensive burrow systems. High humidity levels in the burrows prevent mole-rats from thermoregulating using evaporative cooling. However, the relatively stable environment of the burrows promotes moderate temperatures and small daily temperature fluctuations. Mole-rats therefore display a relatively wide range of thermoregulation abilities. Some species cannot maintain their body temperatures at a constant level, whereas others employ behavioural thermoregulation. Here we test the effect of ambient temperature on locomotor activity and body temperature, and the relationship between the two parameters, in the highveld mole-rat. We exposed mole-rats to a 12L:12D and a DD light cycle at ambient temperatures of 30°C, 25°C and 20°C while locomotor activity and body temperature were measured simultaneously. In addition, we investigated the endogenous rhythms of locomotor activity and body temperature at different ambient temperatures. Mole-rats displayed nocturnal activity at all three ambient temperatures and were most active at 20°C, but least active at 30°C. Body temperature was highest at 30°C and lowest at 20°C, and the daily cycle was highly correlated with locomotor activity. We show that the mole-rats have endogenous rhythms for both locomotor activity and body temperature. However, the endogenous body temperature rhythm appears to be less robust compared to the locomotor activity rhythm. Female mole-rats appear to be more sensitive to temperature changes than males, increased heterothermy is evident at lower ambient temperatures, whilst males show smaller variation in their body temperatures with changing ambient temperatures. Mole-rats may rely more heavily on behavioural thermoregulation as it is more energy efficient in an already challenging environment.
[Mh] Termos MeSH primário: Regulação da Temperatura Corporal
Temperatura Corporal
Locomoção
Ratos-Toupeira/fisiologia
[Mh] Termos MeSH secundário: Animais
Comportamento Animal
Ritmo Circadiano
Fotoperíodo
Ratos
Solo
Temperatura Ambiente
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Soil)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170111
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0169644


  8 / 413 MEDLINE  
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[PMID]:27682432
[Au] Autor:Montoya-Sanhueza G; Chinsamy A
[Ad] Endereço:Department of Biological Sciences, Palaeobiological Research Group, University of Cape Town, Cape Town, South Africa.
[Ti] Título:Long bone histology of the subterranean rodent Bathyergus suillus (Bathyergidae): ontogenetic pattern of cortical bone thickening.
[So] Source:J Anat;230(2):203-233, 2017 Feb.
[Is] ISSN:1469-7580
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Patterns of bone development in mammals are best known from terrestrial and cursorial groups, but there is a considerable gap in our understanding of how specializations for life underground affect bone growth and development. Likewise, studies of bone microstructure in wild populations are still scarce, and they often include few individuals and tend to be focused on adults. For these reasons, the processes generating bone microstructural variation at intra- and interspecific levels are not fully understood. This study comprehensively examines the bone microstructure of an extant population of Cape dune molerats, Bathyergus suillus (Bathyergidae), the largest subterranean mammal endemic to the Western Cape of South Africa. The aim of this study is to investigate the postnatal bone growth of B. suillus using undecalcified histological sections (n = 197) of the femur, humerus, tibia-fibula, ulna and radius, including males and females belonging to different ontogenetic and reproductive stages (n = 42). Qualitative histological features demonstrate a wide histodiversity with thickening of the cortex mainly resulting from endosteal and periosteal bone depositions, whilst there is scarce endosteal resorption and remodeling throughout ontogeny. This imbalanced bone modeling allows the tissues deposited during ontogeny to remain relatively intact, thus preserving an excellent record of growth. The distribution of the different bone tissues observed in the cortex depends on ontogenetic status, anatomical features (e.g. muscle attachment structures) and location on the bone (e.g. anterior or lateral). The type of bone microstructure and modeling is discussed in relation to digging behavior, reproduction and physiology of this species. This study is the first histological assessment describing the process of cortical thickening in long bones of a fossorial mammal.
[Mh] Termos MeSH primário: Densidade Óssea
Osso Cortical/citologia
Fêmur/citologia
Ratos-Toupeira/anatomia & histologia
[Mh] Termos MeSH secundário: Animais
Densidade Óssea/fisiologia
Osso Cortical/fisiologia
Feminino
Fêmur/fisiologia
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170904
[Lr] Data última revisão:
170904
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160930
[St] Status:MEDLINE
[do] DOI:10.1111/joa.12547


  9 / 413 MEDLINE  
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[PMID]:27350178
[Au] Autor:Park KK; Luo X; Mooney SJ; Yungher BJ; Belin S; Wang C; Holmes MM; He Z
[Ad] Endereço:Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, Florida, 33136.
[Ti] Título:Retinal ganglion cell survival and axon regeneration after optic nerve injury in naked mole-rats.
[So] Source:J Comp Neurol;525(2):380-388, 2017 Feb 01.
[Is] ISSN:1096-9861
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In the adult mammalian central nervous system (CNS), axonal damage often triggers neuronal cell death and glial activation, with very limited spontaneous axon regeneration. In this study, we performed optic nerve injury in adult naked mole-rats, the longest living rodent, with a maximum life span exceeding 30 years, and found that injury responses in this species are quite distinct from those in other mammalian species. In contrast to what is seen in other mammals, the majority of injured retinal ganglion cells (RGCs) survive with relatively high spontaneous axon regeneration. Furthermore, injured RGCs display activated signal transducer and activator of transcription-3 (STAT3), whereas astrocytes in the optic nerve robustly occupy and fill the lesion area days after injury. These neuron-intrinsic and -extrinsic injury responses are reminiscent of those in "cold-blooded" animals, such as fish and amphibians, suggesting that the naked mole-rat is a powerful model for exploring the mechanisms of neuronal injury responses and axon regeneration in mammals. J. Comp. Neurol. 525:380-388, 2017. © 2016 Wiley Periodicals, Inc.
[Mh] Termos MeSH primário: Axônios/fisiologia
Regeneração Nervosa/fisiologia
Traumatismos do Nervo Óptico/fisiopatologia
Células Ganglionares da Retina/fisiologia
[Mh] Termos MeSH secundário: Animais
Sobrevivência Celular
Modelos Animais de Doenças
Imuno-Histoquímica
Ratos-Toupeira
Ratos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170929
[Lr] Data última revisão:
170929
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160629
[St] Status:MEDLINE
[do] DOI:10.1002/cne.24070


  10 / 413 MEDLINE  
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[PMID]:27129918
[Au] Autor:Taylor KR; Milone NA; Rodriguez CE
[Ad] Endereço:Disney's Animal Kingdom, Walt Disney World Resort, Bay Lake, Florida. ky.t@ufl.edu.
[Ti] Título:Four Cases of Spontaneous Neoplasia in the Naked Mole-Rat (Heterocephalus glaber), A Putative Cancer-Resistant Species.
[So] Source:J Gerontol A Biol Sci Med Sci;72(1):38-43, 2017 Jan.
[Is] ISSN:1758-535X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The naked mole-rat (Heterocephalus glaber) is widely acclaimed to be cancer-resistant and of considerable research interest based on a paucity of reports of neoplasia in this species. We have, however, encountered four spontaneous cases of neoplasia and one presumptive case of neoplasia through routine necropsy and biopsy of individuals in a zoo collection of nonhybrid naked mole-rats bred from a single pair. One case each of metastasizing hepatocellular carcinoma, nephroblastoma (Wilms' tumor), and multicentric lymphosarcoma, as well as presumptive esophageal adenocarcinoma (Barrett's esophagus-like) was identified postmortem among 37 nonautolyzed necropsy submissions of naked mole-rats over 1-year-old that were submitted for necropsy between 1998 and August 2015. One incidental case of cutaneous hemangioma was also identified antemortem by skin biopsy from one naked mole-rat examined for trauma.
[Mh] Termos MeSH primário: Adenocarcinoma/patologia
Carcinoma Hepatocelular/patologia
Hemangioma/patologia
Linfoma não Hodgkin/patologia
Tumor de Wilms/patologia
[Mh] Termos MeSH secundário: Animais
Neoplasias Esofágicas/patologia
Neoplasias Renais/patologia
Neoplasias Hepáticas/patologia
Ratos-Toupeira
Neoplasias Cutâneas/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170807
[Lr] Data última revisão:
170807
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:160501
[St] Status:MEDLINE



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