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Pesquisa : B01.050.150.900.649.313.992.600.700 [Categoria DeCS]
Referências encontradas : 50 [refinar]
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[PMID]:27590526
[Au] Autor:Domankevich V; Opatowsky Y; Malik A; Korol AB; Frenkel Z; Manov I; Avivi A; Shams I
[Ad] Endereço:Institute of Evolution & Department of Evolutionary and Environmental Biology, University of Haifa, Haifa, Israel.
[Ti] Título:Adaptive patterns in the p53 protein sequence of the hypoxia- and cancer-tolerant blind mole rat Spalax.
[So] Source:BMC Evol Biol;16:177, 2016 Sep 02.
[Is] ISSN:1471-2148
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The subterranean blind mole rat, Spalax (genus Nannospalax) endures extreme hypoxic conditions and fluctuations in oxygen levels that threaten DNA integrity. Nevertheless, Spalax is long-lived, does not develop spontaneous cancer, and exhibits an outstanding resistance to carcinogenesis in vivo, as well as anti-cancer capabilities in vitro. We hypothesized that adaptations to similar extreme environmental conditions involve common mechanisms for overcoming stress-induced DNA damage. Therefore, we aimed to identify shared features among species that are adapted to hypoxic stress in the sequence of the tumor-suppressor protein p53, a master regulator of the DNA-damage response (DDR). RESULTS: We found that the sequences of p53 transactivation subdomain 2 (TAD2) and tetramerization and regulatory domains (TD and RD) are more similar among hypoxia-tolerant species than expected from phylogeny. Specific positions in these domains composed patterns that are more frequent in hypoxia-tolerant species and have proven to be good predictors of species' classification into stress-related categories. Some of these positions, which are known to be involved in the interactions between p53 and critical DDR proteins, were identified as positively selected. By 3D modeling of p53 interactions with the coactivator p300 and the DNA repair protein RPA70, we demonstrated that, compared to humans, these substitutions potentially reduce the binding of these proteins to Spalax p53. CONCLUSIONS: We conclude that extreme hypoxic conditions may have led to convergent evolutionary adaptations of the DDR via TAD2 and TD/RD domains of p53.
[Mh] Termos MeSH primário: Evolução Biológica
Reparo do DNA
Spalax/genética
Proteína Supressora de Tumor p53/genética
[Mh] Termos MeSH secundário: Adaptação Fisiológica
Sequência de Aminoácidos
Animais
Hipóxia/veterinária
Modelos Moleculares
Neoplasias/genética
Neoplasias/veterinária
Oxigênio/metabolismo
Alinhamento de Sequência
Spalax/metabolismo
Proteína Supressora de Tumor p53/química
Proteína Supressora de Tumor p53/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Tumor Suppressor Protein p53); S88TT14065 (Oxygen)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170630
[Lr] Data última revisão:
170630
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160904
[St] Status:MEDLINE
[do] DOI:10.1186/s12862-016-0743-8


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[PMID]:27339131
[Au] Autor:Li K; Wang L; Knisbacher BA; Xu Q; Levanon EY; Wang H; Frenkel-Morgenstern M; Tagore S; Fang X; Bazak L; Buchumenski I; Zhao Y; Lövy M; Li X; Han L; Frenkel Z; Beiles A; Cao YB; Wang ZL; Nevo E
[Ad] Endereço:Institute of Apicultural Research, Chinese Academy of Agricultural Sciences, Beijing 100093, China; Institute of Evolution, University of Haifa, Haifa 3498838, Israel; nevo@research.haifa.ac.il likexin323@gmail.com sky109@zjnu.edu.cn wzl@zzu.edu.cn.
[Ti] Título:Transcriptome, genetic editing, and microRNA divergence substantiate sympatric speciation of blind mole rat, Spalax.
[So] Source:Proc Natl Acad Sci U S A;113(27):7584-9, 2016 07 05.
[Is] ISSN:1091-6490
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Incipient sympatric speciation in blind mole rat, Spalax galili, in Israel, caused by sharp ecological divergence of abutting chalk-basalt ecologies, has been proposed previously based on mitochondrial and whole-genome nuclear DNA. Here, we present new evidence, including transcriptome, DNA editing, microRNA, and codon usage, substantiating earlier evidence for adaptive divergence in the abutting chalk and basalt populations. Genetic divergence, based on the previous and new evidence, is ongoing despite restricted gene flow between the two populations. The principal component analysis, neighbor-joining tree, and genetic structure analysis of the transcriptome clearly show the clustered divergent two mole rat populations. Gene-expression level analysis indicates that the population transcriptome divergence is displayed not only by soil divergence but also by sex. Gene ontology enrichment of the differentially expressed genes from the two abutting soil populations highlights reproductive isolation. Alternative splicing variation of the two abutting soil populations displays two distinct splicing patterns. L-shaped FST distribution indicates that the two populations have undergone divergence with gene flow. Transcriptome divergent genes highlight neurogenetics and nutrition characterizing the chalk population, and energetics, metabolism, musculature, and sensory perception characterizing the abutting basalt population. Remarkably, microRNAs also display divergence between the two populations. The GC content is significantly higher in chalk than in basalt, and stress-response genes mostly prefer nonoptimal codons. The multiple lines of evidence of ecological-genomic and genetic divergence highlight that natural selection overrules the gene flow between the two abutting populations, substantiating the sharp ecological chalk-basalt divergence driving sympatric speciation.
[Mh] Termos MeSH primário: Especiação Genética
MicroRNAs/metabolismo
Spalax/genética
Simpatria
Transcriptoma
[Mh] Termos MeSH secundário: Animais
Carbonato de Cálcio
Ecossistema
Feminino
Fluxo Gênico
Masculino
Silicatos
Solo
Spalax/metabolismo
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (MicroRNAs); 0 (Silicates); 0 (Soil); 0 (basalt); H0G9379FGK (Calcium Carbonate)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160625
[St] Status:MEDLINE
[do] DOI:10.1073/pnas.1607497113


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[PMID]:27232489
[Au] Autor:Dong YJ; Pang Y; Li QW
[Ad] Endereço:1. College of Life Science, Liaoning Normal University, Dalian 116029, China; 2. Lamprey Research Center, Liaoning Normal University, Dalian 116029, China;
[Ti] Título:[The anti-tumor mechanisms in long-lived rodents].
[So] Source:Yi Chuan;38(5):411-7, 2016 05.
[Is] ISSN:0253-9772
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:Rodents, including the nude mice with congenital aplasia of the thymus, cancer-resistant naked mole rat (Heterocephalus glaber) and blind mole rat (Spalax galili), are important model organisms that are widely used in biomedical research. The aging process is closely related to cancer incidence in mammals and the aging degree is positively correlated with the risk of cancer. Since rodents account for 40% of mammals, study of the unique antitumor mechanism in long-lived rodents is very important. Replicative senescence is anti-tumor mechanism that prevalently exist in rodents, however, unique anti-tumor mechanisms have been found in naked mole-rats and blind mole-rats. The cancer resistance of Spalax galili is mediated by cell-released IFN-ß which activates p53 and Rb signaling pathway and the cells undergoes concerted cell death while that of Heterocephalus glaber is mediated by high molecular weight hyaluronan (HMW-HA) which causes contact inhibition. In addition, highly expressed pro-cell-death and anti-inflammation related genes are found in the genome of both naked mole-rats and blind mole-rats. In this review, we summarize the anti-tumor mechanisms in both Heterocephalus glaber and Spalax galili, which may provide information for related research.
[Mh] Termos MeSH primário: Ratos-Toupeira/genética
Neoplasias/veterinária
Doenças dos Roedores/genética
Spalax/genética
[Mh] Termos MeSH secundário: Animais
Senescência Celular
Ácido Hialurônico/fisiologia
Interferon beta/fisiologia
Neoplasias/genética
Proteína do Retinoblastoma/fisiologia
Proteína Supressora de Tumor p53/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Retinoblastoma Protein); 0 (Tumor Suppressor Protein p53); 77238-31-4 (Interferon-beta); 9004-61-9 (Hyaluronic Acid)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160528
[St] Status:MEDLINE
[do] DOI:10.16288/j.yczz.15-511


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[PMID]:27050459
[Au] Autor:Rodriguez KA; Li K; Nevo E; Buffenstein R
[Ad] Endereço:a Sam and Anne Barshop Center for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio (UTHSCSA) , San Antonio , TX , USA.
[Ti] Título:Mechanisms regulating proteostasis are involved in sympatric speciation of the blind mole rat, Spalax galili.
[So] Source:Autophagy;12(4):703-4, 2016.
[Is] ISSN:1554-8635
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Genome-wide analysis demonstrates extensive genomic adaptive complexes involved in sympatric speciation between blind mole rats (Spalax galili) in abutting populations living in basalt and chalk soils. Among the gene ontology (GO) enrichment, musculature and metabolism stood out in basalt dwellers while nutrition and neurogenetics were highlighted in chalk residents. Measurements of mechanisms regulating protein homeostasis inspired by these GO terms suggest that at the proteomic level there is also a habitat/soil-type driven divergence with the basalt residents exhibiting higher proteasome activity whereas elevated levels of markers of autophagy are evident in the chalk inhabitants.
[Mh] Termos MeSH primário: Especiação Genética
Homeostase
Proteínas/metabolismo
Spalax/metabolismo
Simpatria
[Mh] Termos MeSH secundário: Animais
Regulação da Expressão Gênica
Ontologia Genética
Proteólise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Proteins)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160407
[St] Status:MEDLINE
[do] DOI:10.1080/15548627.2016.1143592


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[PMID]:26858405
[Au] Autor:Zhao Y; Tang JW; Yang Z; Cao YB; Ren JL; Ben-Abu Y; Li K; Chen XQ; Du JZ; Nevo E
[Ad] Endereço:Division of Neurobiology and Physiology, Department of Basic Medical Sciences, School of Medicine, Zhejiang University, Hangzhou 310058, China; Key Laboratory of Medical Neurobiology of the Ministry of Health, Hangzhou 310058, China; Key Laboratory of Neuroscience of Zhejiang Province, Hangzhou 3100
[Ti] Título:Adaptive methylation regulation of p53 pathway in sympatric speciation of blind mole rats, Spalax.
[So] Source:Proc Natl Acad Sci U S A;113(8):2146-51, 2016 Feb 23.
[Is] ISSN:1091-6490
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Epigenetic modifications play significant roles in adaptive evolution. The tumor suppressor p53, well known for controlling cell fate and maintaining genomic stability, is much less known as a master gene in environmental adaptation involving methylation modifications. The blind subterranean mole rat Spalax eherenbergi superspecies in Israel consists of four species that speciated peripatrically. Remarkably, the northern Galilee species Spalax galili (2n = 52) underwent adaptive ecological sympatric speciation, caused by the sharply divergent chalk and basalt ecologies. This was demonstrated by mitochondrial and nuclear genomic evidence. Here we show that the expression patterns of the p53 regulatory pathway diversified between the abutting sympatric populations of S. galili in sharply divergent chalk-basalt ecologies. We identified higher methylation on several sites of the p53 promoter in the population living in chalk soil (chalk population). Site mutagenesis showed that methylation on these sites linked to the transcriptional repression of p53 involving Cut-Like Homeobox 1 (Cux1), paired box 4 (Pax 4), Pax 6, and activator protein 1 (AP-1). Diverse expression levels of p53 between the incipiently sympatrically speciating chalk-basalt abutting populations of S. galili selectively affected cell-cycle arrest but not apoptosis. We hypothesize that methylation modification of p53 has adaptively shifted in supervising its target genes during sympatric speciation of S. galili to cope with the contrasting environmental stresses of the abutting divergent chalk-basalt ecologies.
[Mh] Termos MeSH primário: Metilação de DNA
Genes p53
Spalax/genética
Spalax/metabolismo
[Mh] Termos MeSH secundário: Adaptação Biológica
Animais
Carbonato de Cálcio
Pontos de Checagem do Ciclo Celular/genética
Ecossistema
Evolução Molecular
Expressão Gênica
Especiação Genética
Genética Populacional
Pulmão/metabolismo
Regiões Promotoras Genéticas
Silicatos
Solo
Spalax/classificação
Simpatria
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Silicates); 0 (Soil); 0 (basalt); H0G9379FGK (Calcium Carbonate)
[Em] Mês de entrada:1607
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160210
[St] Status:MEDLINE
[do] DOI:10.1073/pnas.1522658112


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[PMID]:26340990
[Au] Autor:Li K; Hong W; Jiao H; Wang GD; Rodriguez KA; Buffenstein R; Zhao Y; Nevo E; Zhao H
[Ad] Endereço:Department of Ecology, College of Life Sciences, Wuhan University, Wuhan 430072, China; Institute of Evolution, University of Haifa, Haifa 3498838, Israel;
[Ti] Título:Sympatric speciation revealed by genome-wide divergence in the blind mole rat Spalax.
[So] Source:Proc Natl Acad Sci U S A;112(38):11905-10, 2015 Sep 22.
[Is] ISSN:1091-6490
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Sympatric speciation (SS), i.e., speciation within a freely breeding population or in contiguous populations, was first proposed by Darwin [Darwin C (1859) On the Origins of Species by Means of Natural Selection] and is still controversial despite theoretical support [Gavrilets S (2004) Fitness Landscapes and the Origin of Species (MPB-41)] and mounting empirical evidence. Speciation of subterranean mammals generally, including the genus Spalax, was considered hitherto allopatric, whereby new species arise primarily through geographic isolation. Here we show in Spalax a case of genome-wide divergence analysis in mammals, demonstrating that SS in continuous populations, with gene flow, encompasses multiple widespread genomic adaptive complexes, associated with the sharply divergent ecologies. The two abutting soil populations of S. galili in northern Israel habituate the ancestral Senonian chalk population and abutting derivative Plio-Pleistocene basalt population. Population divergence originated ∼0.2-0.4 Mya based on both nuclear and mitochondrial genome analyses. Population structure analysis displayed two distinctly divergent clusters of chalk and basalt populations. Natural selection has acted on 300+ genes across the genome, diverging Spalax chalk and basalt soil populations. Gene ontology enrichment analysis highlights strong but differential soil population adaptive complexes: in basalt, sensory perception, musculature, metabolism, and energetics, and in chalk, nutrition and neurogenetics are outstanding. Population differentiation of chemoreceptor genes suggests intersoil population's mate and habitat choice substantiating SS. Importantly, distinctions in protein degradation may also contribute to SS. Natural selection and natural genetic engineering [Shapiro JA (2011) Evolution: A View From the 21st Century] overrule gene flow, evolving divergent ecological adaptive complexes. Sharp ecological divergences abound in nature; therefore, SS appears to be an important mode of speciation as first envisaged by Darwin [Darwin C (1859) On the Origins of Species by Means of Natural Selection].
[Mh] Termos MeSH primário: Especiação Genética
Variação Genética
Genoma
Spalax/genética
Simpatria/genética
[Mh] Termos MeSH secundário: Animais
Teorema de Bayes
Ontologia Genética
Desequilíbrio de Ligação/genética
Dados de Sequência Molecular
Filogenia
Polimorfismo de Nucleotídeo Único/genética
Dinâmica Populacional
Proteólise
Receptores Odorantes/genética
Análise de Sequência de DNA
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Receptors, Odorant)
[Em] Mês de entrada:1512
[Cu] Atualização por classe:170408
[Lr] Data última revisão:
170408
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150906
[St] Status:MEDLINE
[do] DOI:10.1073/pnas.1514896112


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[PMID]:26192762
[Au] Autor:Lövy M; Sklíba J; Hrouzková E; Dvoráková V; Nevo E; Sumbera R
[Ad] Endereço:Department of Zoology, Faculty of Science, University of South Bohemia, Ceské Budejovice, Czech Republic.
[Ti] Título:Habitat and Burrow System Characteristics of the Blind Mole Rat Spalax galili in an Area of Supposed Sympatric Speciation.
[So] Source:PLoS One;10(7):e0133157, 2015.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A costly search for food in subterranean rodents resulted in various adaptations improving their foraging success under given ecological conditions. In Spalax ehrenbergi superspecies, adaptations to local ecological conditions can promote speciation, which was recently supposed to occur even in sympatry at sites where two soil types of contrasting characteristics abut each other. Quantitative description of ecological conditions in such a site has been, nevertheless, missing. We measured characteristics of food supply and soil within 16 home ranges of blind mole rats Spalax galili in an area subdivided into two parts formed by basaltic soil and pale rendzina. We also mapped nine complete mole rat burrow systems to compare burrowing patterns between the soil types. Basaltic soil had a higher food supply and was harder than rendzina even under higher moisture content and lower bulk density. Population density of mole rats was five-times lower in rendzina, possibly due to the lower food supply and higher cover of Sarcopoterium shrubs which seem to be avoided by mole rats. A combination of food supply and soil parameters probably influences burrowing patterns resulting in shorter and more complex burrow systems in basaltic soil.
[Mh] Termos MeSH primário: Adaptação Fisiológica/genética
Ecossistema
Especiação Genética
Solo
Spalax/fisiologia
Simpatria/fisiologia
[Mh] Termos MeSH secundário: Animais
Comportamento Animal
Spalax/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Soil)
[Em] Mês de entrada:1604
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150721
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0133157


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[PMID]:25339103
[Au] Autor:Vernochet C; Redelsperger F; Harper F; Souquere S; Catzeflis F; Pierron G; Nevo E; Heidmann T; Dupressoir A
[Ad] Endereço:Unité des Rétrovirus Endogènes et Eléments Rétroïdes des Eucaryotes Supérieurs, Centre National de la Recherche Scientifique Unité Mixte de Recherche 8122, Institut Gustave Roussy, Villejuif, France Université Paris-Sud, Orsay, France.
[Ti] Título:The captured retroviral envelope syncytin-A and syncytin-B genes are conserved in the Spalacidae together with hemotrichorial placentation.
[So] Source:Biol Reprod;91(6):148, 2014 Dec.
[Is] ISSN:1529-7268
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Syncytins are fusogenic envelope (env) genes of retroviral origin that have been captured for a function in placentation. Multiple independent events of syncytin gene capture were found to have occurred in primates, rodents, lagomorphs, carnivores, and ruminants. In the mouse, two syncytin-A and -B genes are present, which trigger the formation of the two-layered placental syncytiotrophoblast at the maternal-fetal interface, a structure classified as hemotrichorial. Here, we identified syncytin-A and -B orthologous genes in the genome of all Muroidea species analyzed, thus dating their capture back to about at least 40 million years ago, with evidence that they evolved under strong purifying selection. We further show, in the divergent Spalacidae lineage (blind mole rats [Spalax]), that both syncytins have conserved placenta-specific expression, as revealed by RT-PCR analysis of a panel of Spalax galili tissues, and display fusogenic activity, using ex vivo cell-cell fusion assays. Refined analysis of the placental architecture and ultrastructure revealed that the Spalax placenta displays a hemotrichorial organization of the interhemal membranes, as similarly observed for other Muroidea species, yet with only one trophoblastic cell layer being clearly syncytialized. In situ hybridization experiments further localized syncytin transcripts at the level of these differentiated interhemal membranes. These findings argue for a role of syncytin gene capture in the establishment of the original hemotrichorial placenta of Muroidea, and more generally in the diversity of placental structures among mammals.
[Mh] Termos MeSH primário: Retrovirus Endógenos/genética
Produtos do Gene env/genética
Placentação
Proteínas da Gravidez/genética
Spalax/genética
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Animais
Arvicolinae
Sequência Conservada
Cricetinae
Feminino
Camundongos
Ratos-Toupeira
Dados de Sequência Molecular
Filogenia
Placentação/genética
Gravidez
Ratos
Homologia de Sequência de Aminoácidos
Proteínas do Envelope Viral/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Gene Products, env); 0 (Pregnancy Proteins); 0 (Viral Envelope Proteins); 0 (syncytin)
[Em] Mês de entrada:1508
[Cu] Atualização por classe:141219
[Lr] Data última revisão:
141219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141024
[St] Status:MEDLINE
[do] DOI:10.1095/biolreprod.114.124818


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[PMID]:25050761
[Au] Autor:Iancu TC; Arad T; Shams I; Manov I
[Ad] Endereço:The Milman-David Biomedical Research Unit, 24 Hazevi Avenue, 34355 Haifa, Israel. Electronic address: tiancu@tx.technion.ac.il.
[Ti] Título:Iron-rich ferritin in the hypoxia-tolerant rodent Spalax ehrenbergi: a naturally-occurring biomarker confirms the internalization and pathways of intracellular macromolecules.
[So] Source:J Struct Biol;187(3):254-265, 2014 Sep.
[Is] ISSN:1095-8657
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The discovery of pits/caveolae in the plasmalemma advanced the study of macromolecule internalization. "Transcytosis" describes the transport of macromolecular cargo from one front of a polarized cell to the other within membrane-bounded carrier(s), via endocytosis, intracellular trafficking and exocytosis. Clathrin-mediated transcytosis is used extensively by epithelial cells, while caveolae-mediated transcytosis mostly occurs in endothelial cells. The internalization pathways were monitored by various markers, including radioisotopes, nanoparticles, enzymes, immunostains, and fluorophores. We describe an internalization pathway identified using a naturally-occurring biomarker, in vivo assembled ferritin, containing electron-dense iron cores. Iron, an essential trace metal for most living species and iron homeostasis, is crucial for cellular life. Ferritin is a ubiquitous and highly conserved archeoprotein whose main function is to store a reserve iron supply inside the cytoplasm in a non-toxic form. Ferritin is present in all organisms which have a metabolic requirement for iron and in even in organisms whose taxonomic rank is very low. The newborns of the blind mole, Spalax ehrenbergi, are born and live in a hypoxic environment and have significant iron overload in their liver and heart, but their iron metabolism has not been previously studied. These newborns, which are evolutionarily adapted to fluctuations in the environmental oxygen, have a unique ability to sequester transplacental iron and store it in ferritin without any signs of iron toxicity. Using the ferrihydrite cores of ferritin, we were able to monitor the ferritin internalization from portals of its entry into the cytosol of hepatocytes and cardiomyocytes and into the lysosomes.
[Mh] Termos MeSH primário: Biomarcadores/metabolismo
Endocitose/fisiologia
Ferritinas/metabolismo
Substâncias Macromoleculares/metabolismo
Transdução de Sinais/fisiologia
[Mh] Termos MeSH secundário: Animais
Animais Recém-Nascidos
Compostos Férricos/química
Compostos Férricos/metabolismo
Ferritinas/química
Ferritinas/ultraestrutura
Hepatócitos/metabolismo
Hepatócitos/ultraestrutura
Hipóxia
Espaço Intracelular/metabolismo
Ferro/química
Fígado/citologia
Fígado/metabolismo
Fígado/ultraestrutura
Microscopia Eletrônica de Transmissão
Miocárdio/citologia
Miocárdio/metabolismo
Miocárdio/ultraestrutura
Miócitos Cardíacos/metabolismo
Miócitos Cardíacos/ultraestrutura
Spalax
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Biomarkers); 0 (Ferric Compounds); 0 (Macromolecular Substances); 87PZU03K0K (ferric oxyhydroxide); 9007-73-2 (Ferritins); E1UOL152H7 (Iron)
[Em] Mês de entrada:1505
[Cu] Atualização por classe:170829
[Lr] Data última revisão:
170829
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140723
[St] Status:MEDLINE


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[PMID]:24974702
[Au] Autor:Deweerdt S
[Ti] Título:Naked ambition.
[So] Source:Sci Am;311(1):S14-5, 2014 Jul.
[Is] ISSN:0036-8733
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Ratos-Toupeira
Neoplasias/prevenção & controle
[Mh] Termos MeSH secundário: Animais
Seres Humanos
Modelos Animais
Ratos-Toupeira/genética
Neoplasias/genética
Spalax
Proteína Supressora de Tumor p53/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Tumor Suppressor Protein p53)
[Em] Mês de entrada:1407
[Cu] Atualização por classe:140630
[Lr] Data última revisão:
140630
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140701
[St] Status:MEDLINE



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