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  1 / 873 MEDLINE  
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[PMID]:29023516
[Au] Autor:Cubuk C; Markowsky H; Herwig A
[Ad] Endereço:Zoologisches Institut, Universität Hamburg, Hamburg, Germany.
[Ti] Título:Hypothalamic control systems show differential gene expression during spontaneous daily torpor and fasting-induced torpor in the Djungarian hamster (Phodopus sungorus).
[So] Source:PLoS One;12(10):e0186299, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Djungarian hamsters are able to use spontaneous daily torpor (SDT) during the winter season as well as fasting-induced torpor (FIT) at any time of the year to cope with energetically challenging environmental conditions. Torpor is a state of severely reduced metabolism with a pronounced decrease in body temperature, which enables animals to decrease their individual energy requirements. Despite sharing common characteristics, such as reduced body mass before first torpor expression and depressed metabolism and body temperature during the torpid state, FIT and SDT differ in several physiological properties including torpor bout duration, minimal body temperature, fuel utilization and circadian organization. It remains unclear, whether SDT and FIT reflect the same phenomenon or two different physiological states. The hypothalamus has been suggested to play a key role in regulating energy balance and torpor. To uncover differences in molecular control mechanisms of torpor expression, we set out to investigate hypothalamic gene expression profiles of genes related to orexigenic (Agrp/Npy), circadian clock (Bmal1/Per1) and thyroid hormone (Dio2/Mct8) systems of animals undergoing SDT and FIT during different torpor stages. Orexigenic genes were mainly regulated during FIT and remained largely unaffected by SDT. Expression patterns of clock genes showed disturbed circadian clock rhythmicity in animals undergoing FIT, but not in animals undergoing SDT. During both, SDT and FIT, decreased Dio2 expression was detected, indicating reduced hypothalamic T3 availability in both types of torpor. Taken together, our results provide evidence that SDT and FIT also differ in certain central control mechanisms and support the observation that animals undergoing SDT are in energetical balance, whereas animals undergoing FIT display a negative energy balance. This should be carefully taken into account when interpreting data in torpor research, especially from animal models of fasting-induced hypometabolism such as mice.
[Mh] Termos MeSH primário: Hipotálamo/metabolismo
Phodopus/metabolismo
Torpor/fisiologia
[Mh] Termos MeSH secundário: Fatores de Transcrição ARNTL/genética
Fatores de Transcrição ARNTL/metabolismo
Proteína Relacionada com Agouti/genética
Proteína Relacionada com Agouti/metabolismo
Animais
Temperatura Corporal
Ritmo Circadiano/genética
Cricetinae
Metabolismo Energético
Jejum
Iodeto Peroxidase/genética
Iodeto Peroxidase/metabolismo
RNA/química
RNA/isolamento & purificação
RNA/metabolismo
RNA Mensageiro/metabolismo
Reação em Cadeia da Polimerase em Tempo Real
Análise de Sequência de DNA
Transcriptoma
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (ARNTL Transcription Factors); 0 (Agouti-Related Protein); 0 (RNA, Messenger); 63231-63-0 (RNA); EC 1.11.1.- (iodothyronine deiodinase type II); EC 1.11.1.8 (Iodide Peroxidase)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171024
[Lr] Data última revisão:
171024
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171013
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0186299


  2 / 873 MEDLINE  
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[PMID]:29022861
[Au] Autor:Kocjan BJ; Hosnjak L; Racnik J; Zadravec M; Bakovnik N; Cigler B; Ummelen M; Hopman AHN; Gale N; Svara T; Gombac M; Poljak M
[Ad] Endereço:1​Institute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
[Ti] Título:Molecular characterization, prevalence and clinical relevance of Phodopus sungorus papillomavirus type 1 (PsuPV1) naturally infecting Siberian hamsters (Phodopus sungorus).
[So] Source:J Gen Virol;98(11):2799-2809, 2017 Nov.
[Is] ISSN:1465-2099
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Phodopus sungorus papillomavirus type 1 (PsuPV1), naturally infecting Siberian hamsters (Phodopus sungorus) and clustering in the genus Pipapillomavirus (Pi-PV), is only the second PV type isolated from the subfamily of hamsters. In silico analysis of three independent complete viral genomes obtained from cervical adenocarcinoma, oral squamous cell carcinoma and normal oral mucosa revealed that PsuPV1 encodes characteristic viral proteins (E1, E2, E4, E6, E7, L1 and L2) with conserved functional domains and a highly conserved non-coding region. The overall high prevalence (102/114; 89.5 %) of PsuPV1 infection in normal oral and anogenital mucosa suggests that asymptomatic infection with PsuPV1 is very frequent in healthy Siberian hamsters from an early age onward, and that the virus is often transmitted between both anatomical sites. Using type-specific real-time PCR and chromogenic in situ hybridization, the presence of PsuPV1 was additionally detected in several investigated tumours (cervical adenocarcinoma, cervical adenomyoma, vaginal carcinoma in situ, ovarian granulosa cell tumour, mammary ductal carcinoma, oral fibrosarcoma, hibernoma and squamous cell papilloma) and normal tissues of adult animals. In the tissue sample of the oral squamous cell carcinoma individual, punctuated PsuPV1-specific in situ hybridization spots were detected within the nuclei of infected animal cells, suggesting viral integration into the host genome and a potential etiological association of PsuPV1 with sporadic cases of this neoplasm.
[Mh] Termos MeSH primário: Variação Genética
Papillomaviridae/classificação
Papillomaviridae/isolamento & purificação
Infecções por Papillomavirus/veterinária
Phodopus
[Mh] Termos MeSH secundário: Canal Anal/virologia
Animais
Doenças Assintomáticas
Genoma Viral
Boca/virologia
Neoplasias/veterinária
Neoplasias/virologia
Papillomaviridae/genética
Infecções por Papillomavirus/epidemiologia
Infecções por Papillomavirus/virologia
Prevalência
Infecções do Sistema Genital/veterinária
Infecções do Sistema Genital/virologia
Análise de Sequência de DNA
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171013
[St] Status:MEDLINE
[do] DOI:10.1099/jgv.0.000943


  3 / 873 MEDLINE  
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[PMID]:28880122
[Au] Autor:Kinnunen SME; Mänttäri SK; Saarela SYO
[Ti] Título:Expression of AMPK, SIRT1, and ACC Differs between Winter- and Summer-Acclimatized Djungarian Hamsters.
[So] Source:Physiol Biochem Zool;90(6):605-612, 2017 Nov/Dec.
[Is] ISSN:1537-5293
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The wintering strategy of the Djungarian hamster (Phodopus sungorus) includes a naturally occurring decrease in food intake and body mass. Our aim was to investigate the conceivable role of the metabolic regulators, AMP-activated protein kinase (AMPK) and sirtuin 1 (SIRT1), in the seasonal adaptation of the Djungarian hamster. In addition, a rate-limiting enzyme in fatty acid synthesis and oxidation, acetyl CoA carboxylase (ACC), was studied. Relative protein expressions and phosphorylated forms (pAMPK and pACC) were determined by Western blot from subcutaneous white adipose tissues (sWAT), abdominal white adipose tissues (aWAT), interscapular brown adipose tissues (iBAT), skeletal muscle, and hypothalamus of winter- and summer-acclimatized hamsters. The winter group had higher AMPK expression in sWAT, aWAT, and iBAT, but the relative amount of phosphorylated protein (pAMPK/AMPK ratio) was lower in these tissues. Furthermore, ACC expression was higher in sWAT and iBAT of the winter animals. pACC (inactive form) levels were higher in all adipose tissues, yet a lower pACC/ACC ratio was detected in iBAT of the winter hamsters. Muscle AMPK expression was lower but pAMPK/AMPK ratio higher in the winter group. SIRT1 expression was higher in muscle and all adipose tissues of the winter hamsters. Hypothalamic protein expressions did not differ between the groups. Higher expressions of AMPK, ACC, and SIRT1 in WAT and iBAT of the winter hamsters suggest a role in the regulation of lipid reserves and increased thermogenic capacity characteristic to the winter-adapted Djungarian hamsters.
[Mh] Termos MeSH primário: Proteínas Quinases Ativadas por AMP/metabolismo
Aclimatação/fisiologia
Acetil-CoA Carboxilase/metabolismo
Phodopus/fisiologia
Estações do Ano
Sirtuína 1/metabolismo
[Mh] Termos MeSH secundário: Proteínas Quinases Ativadas por AMP/genética
Acetil-CoA Carboxilase/genética
Animais
Cricetinae
Feminino
Regulação da Expressão Gênica/fisiologia
Masculino
Sirtuína 1/genética
Temperatura Ambiente
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
EC 2.7.11.31 (AMP-Activated Protein Kinases); EC 3.5.1.- (Sirtuin 1); EC 6.4.1.2 (Acetyl-CoA Carboxylase)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170908
[St] Status:MEDLINE
[do] DOI:10.1086/694295


  4 / 873 MEDLINE  
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[PMID]:28277958
[Au] Autor:Boratynski JS; Jefimow M; Wojciechowski MS
[Ti] Título:Individual Differences in the Phenotypic Flexibility of Basal Metabolic Rate in Siberian Hamsters Are Consistent on Short- and Long-Term Timescales.
[So] Source:Physiol Biochem Zool;90(2):139-152, 2017 Mar/Apr.
[Is] ISSN:1537-5293
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Basal metabolic rate (BMR) correlates with the cost of life in endothermic animals. It usually differs consistently among individuals in a population, but it may be adjusted in response to predictable or unpredictable changes in the environment. The phenotypic flexibility of BMR is considered an adaptation to living in a stochastic environment; however, whether it is also repeatable it is still unexplored. Assuming that variations in phenotypic flexibility are evolutionarily important, we hypothesized that they are consistently different among individuals. We predicted that not only BMR but also its flexibility in response to changes in ambient temperature (T ) are repeatable on short- and long-term timescales. To examine this, we acclimated Siberian hamsters (Phodopus sungorus) for 100 d to winterlike and then to summerlike conditions, and after each acclimation we exposed them interchangeably to 10° and 28°C for 14 d. The difference in BMR measured after each exposure defined an individual's phenotypic flexibility (ΔBMR). BMR was repeatable within and among seasons. It was also flexible in both seasons, but in winter this flexibility was lower in individuals responding to seasonal changes than in nonresponding ones. When we accounted for individual responsiveness, the repeatability of ΔBMR was significant in winter (τ = 0.48, P = 0.01) and in summer (τ = 0.55, P = 0.005). Finally, the flexibility of BMR in response to changes in T was also repeatable on a long-term timescale, that is, among seasons (τ = 0.31, P = 0.008). Our results indicate the evolutionary importance of the phenotypic flexibility of energy metabolism and suggest that it may be subject to selection.
[Mh] Termos MeSH primário: Metabolismo Basal/fisiologia
Phodopus/fisiologia
[Mh] Termos MeSH secundário: Adaptação Fisiológica
Animais
Regulação da Temperatura Corporal/fisiologia
Cricetinae
Feminino
Masculino
Fenótipo
Estações do Ano
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170727
[Lr] Data última revisão:
170727
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170310
[St] Status:MEDLINE
[do] DOI:10.1086/689870


  5 / 873 MEDLINE  
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[PMID]:28249731
[Au] Autor:Kanda LL; Abdulhay A; Erickson C
[Ad] Endereço:Dept. of Biology, Ithaca College, 953 Danby Rd., Ithaca, NY 14850, USA. Electronic address: lkanda@ithaca.edu.
[Ti] Título:Adult wheel access interaction with activity and boldness personality in Siberian dwarf hamsters (Phodopus sungorus).
[So] Source:Behav Processes;138:82-90, 2017 May.
[Is] ISSN:1872-8308
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Individual animal personalities interact with environmental conditions to generate differences in behavior, a phenomenon of growing interest for understanding the effects of environmental enrichment on captive animals. Wheels are common environmental enrichment for laboratory rodents, but studies conflict on how this influences behavior, and interaction of wheels with individual personalities has rarely been examined. We examined whether wheel access altered personality profiles in adult Siberian dwarf hamsters. We assayed animals in a tunnel maze twice for baseline personality, then again at two and at seven weeks after the experimental group was provisioned with wheels in their home cages. Linear mixed model selection was used to assess changes in behavior over time and across environmental gradient of wheel exposure. While animals showed consistent inter-individual differences in activity, activity personality did not change upon exposure to a wheel. Boldness also varies among individuals, and there is evidence for female boldness scores converging after wheel exposure, that is, opposite shifts in behavior by high and low boldness individuals, although sample size is too small for the mixed model results to be robust. In general, Siberian dwarf hamsters appear to show low behavioral plasticity, particularly in general activity, in response to running wheels.
[Mh] Termos MeSH primário: Atividade Motora/fisiologia
Personalidade/fisiologia
Phodopus/fisiologia
Phodopus/psicologia
[Mh] Termos MeSH secundário: Animais
Cricetinae
Feminino
Individualidade
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170522
[Lr] Data última revisão:
170522
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170303
[St] Status:MEDLINE


  6 / 873 MEDLINE  
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[PMID]:28235047
[Au] Autor:Lewis JE; Brameld JM; Hill P; Cocco C; Noli B; Ferri GL; Barrett P; Ebling FJ; Jethwa PH
[Ad] Endereço:School of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough, United Kingdom.
[Ti] Título:Hypothalamic over-expression of VGF in the Siberian hamster increases energy expenditure and reduces body weight gain.
[So] Source:PLoS One;12(2):e0172724, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:VGF (non-acronymic) was first highlighted to have a role in energy homeostasis through experiments involving dietary manipulation in mice. Fasting increased VGF mRNA in the Arc and levels were subsequently reduced upon refeeding. This anabolic role for VGF was supported by observations in a VGF null (VGF-/-) mouse and in the diet-induced and gold-thioglucose obese mice. However, this anabolic role for VGF has not been supported by a number of subsequent studies investigating the physiological effects of VGF-derived peptides. Intracerebroventricular (ICV) infusion of TLQP-21 increased resting energy expenditure and rectal temperature in mice and protected against diet-induced obesity. Similarly, ICV infusion of TLQP-21 into Siberian hamsters significantly reduced body weight, but this was due to a decrease in food intake, with no effect on energy expenditure. Subsequently NERP-2 was shown to increase food intake in rats via the orexin system, suggesting opposing roles for these VGF-derived peptides. Thus to further elucidate the role of hypothalamic VGF in the regulation of energy homeostasis we utilised a recombinant adeno-associated viral vector to over-express VGF in adult male Siberian hamsters, thus avoiding any developmental effects or associated functional compensation. Initially, hypothalamic over-expression of VGF in adult Siberian hamsters produced no effect on metabolic parameters, but by 12 weeks post-infusion hamsters had increased oxygen consumption and a tendency to increased carbon dioxide production; this attenuated body weight gain, reduced interscapular white adipose tissue and resulted in a compensatory increase in food intake. These observed changes in energy expenditure and food intake were associated with an increase in the hypothalamic contents of the VGF-derived peptides AQEE, TLQP and NERP-2. The complex phenotype of the VGF-/- mice is a likely consequence of global ablation of the gene and its derived peptides during development, as well as in the adult.
[Mh] Termos MeSH primário: Peso Corporal/efeitos dos fármacos
Metabolismo Energético/efeitos dos fármacos
Neuropeptídeos/biossíntese
Obesidade/tratamento farmacológico
Ganho de Peso/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Peso Corporal/fisiologia
Cricetinae
Ingestão de Alimentos/efeitos dos fármacos
Ingestão de Alimentos/genética
Regulação da Expressão Gênica/efeitos dos fármacos
Hipotálamo/efeitos dos fármacos
Hipotálamo/metabolismo
Camundongos
Camundongos Obesos
Proteínas do Tecido Nervoso/administração & dosagem
Neuropeptídeos/administração & dosagem
Neuropeptídeos/genética
Obesidade/genética
Obesidade/metabolismo
Consumo de Oxigênio/efeitos dos fármacos
Fragmentos de Peptídeos/administração & dosagem
Phodopus
Ratos
Ganho de Peso/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Nerve Tissue Proteins); 0 (Neuropeptides); 0 (Peptide Fragments); 0 (TLQP-21 peptide); 0 (VGF peptide); 0 (neuroendocrine regulatory peptide-2, mouse)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170815
[Lr] Data última revisão:
170815
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170225
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0172724


  7 / 873 MEDLINE  
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[PMID]:28168294
[Au] Autor:Vyazovskiy VV; Palchykova S; Achermann P; Tobler I; Deboer T
[Ad] Endereço:Department of Physiology, Anatomy and Genetics, University of Oxford, OX1 3PT Oxford, UK.
[Ti] Título:Different Effects of Sleep Deprivation and Torpor on EEG Slow-Wave Characteristics in Djungarian Hamsters.
[So] Source:Cereb Cortex;27(2):950-961, 2017 Feb 01.
[Is] ISSN:1460-2199
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:It has been shown previously in Djungarian hamsters that the initial electroencephalography (EEG) slow-wave activity (power in the 0.5-4.0 Hz band; SWA) in non-rapid eye movement (NREM) sleep following an episode of daily torpor is consistently enhanced, similar to the SWA increase after sleep deprivation (SD). However, it is unknown whether the network mechanisms underlying the SWA increase after torpor and SD are similar. EEG slow waves recorded in the neocortex during sleep reflect synchronized transitions between periods of activity and silence among large neuronal populations. We therefore set out to investigate characteristics of individual cortical EEG slow waves recorded during NREM sleep after 4 h SD and during sleep after emergence from an episode of daily torpor in adult male Djungarian hamsters. We found that during the first hour after both SD and torpor, the SWA increase was associated with an increase in slow-wave incidence and amplitude. However, the slopes of single slow waves during NREM sleep were steeper in the first hour after SD but not after torpor, and, in contrast to sleep after SD, the magnitude of change in slopes after torpor was unrelated to the changes in SWA. Furthermore, slow-wave slopes decreased progressively within the first 2 h after SD, while a progressive increase in slow-wave slopes was apparent during the first 2 h after torpor. The data suggest that prolonged waking and torpor have different effects on cortical network activity underlying slow-wave characteristics, while resulting in a similar homeostatic sleep response of SWA. We suggest that sleep plays an important role in network homeostasis after both waking and torpor, consistent with a recovery function for both states.
[Mh] Termos MeSH primário: Córtex Cerebral/fisiopatologia
Privação do Sono/fisiopatologia
Sono/fisiologia
Torpor/fisiologia
[Mh] Termos MeSH secundário: Animais
Eletrodos Implantados
Eletroencefalografia
Eletromiografia
Homeostase/fisiologia
Masculino
Phodopus
Processamento de Sinais Assistido por Computador
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170425
[Lr] Data última revisão:
170425
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170208
[St] Status:MEDLINE
[do] DOI:10.1093/cercor/bhx020


  8 / 873 MEDLINE  
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[PMID]:28077392
[Au] Autor:Ryu V; Watts AG; Xue B; Bartness TJ
[Ad] Endereço:Department of Biology, Obesity Reversal Center, Georgia State University, Atlanta, Georgia; and vryu@gsu.edu.
[Ti] Título:Bidirectional crosstalk between the sensory and sympathetic motor systems innervating brown and white adipose tissue in male Siberian hamsters.
[So] Source:Am J Physiol Regul Integr Comp Physiol;312(3):R324-R337, 2017 Mar 01.
[Is] ISSN:1522-1490
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The brain networks connected to the sympathetic motor and sensory innervations of brown (BAT) and white (WAT) adipose tissues were originally described using two transneuronally transported viruses: the retrogradely transported pseudorabies virus (PRV), and the anterogradely transported H129 strain of herpes simplex virus-1 (HSV-1 H129). Further complexity was added to this network organization when combined injections of PRV and HSV-1 H129 into either BAT or WAT of the same animal generated sets of coinfected neurons in the brain, spinal cord, and sympathetic and dorsal root ganglia. These neurons are well positioned to act as sensorimotor links in the feedback circuits that control each fat pad. We have now determined the extent of sensorimotor crosstalk between interscapular BAT (IBAT) and inguinal WAT (IWAT). PRV152 and HSV-1 H129 were each injected into IBAT or IWAT of the same animal: H129 into IBAT and PRV152 into IWAT. The reverse configuration was applied in a different set of animals. We found single-labeled neurons together with H129+PRV152 coinfected neurons in multiple brain sites, with lesser numbers in the sympathetic and dorsal root ganglia that innervate IBAT and IWAT. We propose that these coinfected neurons mediate sensory-sympathetic motor crosstalk between IBAT and IWAT. Comparing the relative numbers of coinfected neurons between the two injection configurations showed a bias toward IBAT-sensory and IWAT-sympathetic motor feedback loops. These coinfected neurons provide a neuroanatomical framework for functional interactions between IBAT thermogenesis and IWAT lipolysis that occurs with cold exposure, food restriction/deprivation, exercise, and more generally with alterations in adiposity.
[Mh] Termos MeSH primário: Tecido Adiposo Marrom/citologia
Tecido Adiposo Marrom/inervação
Tecido Adiposo Branco/citologia
Tecido Adiposo Branco/inervação
Córtex Sensório-Motor/citologia
Sistema Nervoso Simpático/citologia
[Mh] Termos MeSH secundário: Tecido Adiposo Marrom/fisiologia
Tecido Adiposo Branco/fisiologia
Animais
Cricetinae
Retroalimentação Sensorial
Masculino
Vias Neurais/citologia
Vias Neurais/fisiologia
Neurônios/citologia
Neurônios/fisiologia
Phodopus
Receptor Cross-Talk
Córtex Sensório-Motor/fisiologia
Sistema Nervoso Simpático/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170626
[Lr] Data última revisão:
170626
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170113
[St] Status:MEDLINE
[do] DOI:10.1152/ajpregu.00456.2015


  9 / 873 MEDLINE  
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[PMID]:28017732
[Au] Autor:Lynch EW; Coyle CS; Stevenson TJ
[Ad] Endereço:Institute for Biological and Environmental Sciences, University of Aberdeen, Aberdeen, UK.
[Ti] Título:Photoperiodic and ovarian steroid regulation of histone deacetylase 1, 2, and 3 in Siberian hamster (Phodopus sungorus) reproductive tissues.
[So] Source:Gen Comp Endocrinol;246:194-199, 2017 May 15.
[Is] ISSN:1095-6840
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Epigenetic modifications in reproductive tissues have predominantly focused on pathological conditions, such as ovarian and uterine cancers. The contribution of DNA methylation and histone acetylation to the timing and control of fertility is not well described. Siberian hamsters provide an important model to investigate the relatively short-term regulation of fertility (e.g. estrous) as well as long-term timing of breeding (e.g. seasonal). Recent work has shown that DNA methyltransferase 3a (dnmt3a) expression is associated with reproductive involution. Here, the objectives were to identify the impact of photoperiod on hdac1-3 expression in hamster testicular, ovarian and uterine tissue. Then, we assessed the effect of E P and estrous cycling on hdac1-3 expression in uterine tissue. Testicular expression of hdac1 was significantly reduced, whereas hdac3 increased in reproductively photoregressed male hamsters; hdac2 expression did not significantly change across photoperiod conditions. There was no significant photoperiodic effect on ovarian expression of hdac1-3. Uterine expression of hdac3 expression was greater in long day hamsters; exposure to short days significantly reduced uterine hdac2 expression. Ovariectomized hamsters administered a single bolus injection of oil were found to have elevated uterine hdac2 compared to E P treated females 12h and 24h post injection. Uterine hdac1-3 expression was relatively constant across the estrous cycle. Altogether these data indicate tissue-dependent photoperiodic regulation of hdac1-3 expression and that E P may inhibit uterine hdac2 over long-term breeding cycles.
[Mh] Termos MeSH primário: Regulação Enzimológica da Expressão Gênica/efeitos dos fármacos
Histona Desacetilase 1/metabolismo
Histona Desacetilase 2/metabolismo
Histona Desacetilases/metabolismo
Ovário/metabolismo
Phodopus/metabolismo
Fotoperíodo
[Mh] Termos MeSH secundário: Animais
Western Blotting
Ritmo Circadiano/efeitos dos fármacos
Cricetinae
Estradiol/farmacologia
Estrogênios/farmacologia
Ciclo Estral/efeitos dos fármacos
Ciclo Estral/metabolismo
Feminino
Histona Desacetilase 1/genética
Histona Desacetilase 2/genética
Histona Desacetilases/genética
Masculino
Ovário/efeitos dos fármacos
Phodopus/genética
Progesterona/farmacologia
Progestinas/farmacologia
RNA Mensageiro/genética
Reação em Cadeia da Polimerase em Tempo Real
Reprodução/efeitos dos fármacos
Reação em Cadeia da Polimerase Via Transcriptase Reversa
Útero/efeitos dos fármacos
Útero/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Estrogens); 0 (Progestins); 0 (RNA, Messenger); 4G7DS2Q64Y (Progesterone); 4TI98Z838E (Estradiol); EC 3.5.1.98 (Histone Deacetylase 1); EC 3.5.1.98 (Histone Deacetylase 2); EC 3.5.1.98 (Histone Deacetylases); EC 3.5.1.98 (histone deacetylase 3)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170515
[Lr] Data última revisão:
170515
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161227
[St] Status:MEDLINE


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[PMID]:27998755
[Au] Autor:Cable EJ; Onishi KG; Prendergast BJ
[Ad] Endereço:Department of Psychology, University of Chicago, Chicago, IL 60637, USA. Electronic address: erinca@uchicago.edu.
[Ti] Título:Circadian rhythms accelerate wound healing in female Siberian hamsters.
[So] Source:Physiol Behav;171:165-174, 2017 Mar 15.
[Is] ISSN:1873-507X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Circadian rhythms (CRs) provide temporal regulation and coordination of numerous physiological traits, including immune function. CRs in multiple aspects of immune function are impaired in rodents that have been rendered circadian-arrhythmic through various methods. In Siberian hamsters, circadian arrhythmia can be induced by disruptive light treatments (DPS). Here we examined CRs in wound healing, and the effects of circadian disruption on wound healing in DPS-arrhythmic hamsters. Circadian entrained/rhythmic (RHYTH) and behaviorally-arrhythmic (ARR) female hamsters were administered a cutaneous wound either 3h after light onset (ZT03) or 2h after dark onset (ZT18); wound size was quantified daily using image analyses. Among RHYTH hamsters, ZT03 wounds healed faster than ZT18 wounds, whereas in ARR hamsters, circadian phase did not affect wound healing. In addition, wounds healed slower in ARR hamsters. The results document a clear CR in wound healing, and indicate that the mere presence of organismal circadian organization enhances this aspect of immune function. Faster wound healing in CR-competent hamsters may be mediated by CR-driven coordination of the temporal order of mechanisms (inflammation, leukocyte trafficking, tissue remodeling) underlying cutaneous wound healing.
[Mh] Termos MeSH primário: Ritmo Circadiano/fisiologia
Dermatopatias/fisiopatologia
Cicatrização/fisiologia
[Mh] Termos MeSH secundário: Animais
Distribuição de Qui-Quadrado
Cricetinae
Modelos Animais de Doenças
Feminino
Luz
Atividade Motora/fisiologia
Phodopus
Fotoperíodo
Dermatopatias/patologia
Dermatopatias/terapia
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170929
[Lr] Data última revisão:
170929
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161222
[St] Status:MEDLINE



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