Base de dados : MEDLINE
Pesquisa : B01.050.150.900.649.313.998 [Categoria DeCS]
Referências encontradas : 26 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 3 ir para página          

  1 / 26 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27329977
[Au] Autor:Chikina M; Robinson JD; Clark NL
[Ad] Endereço:Department of Computational and Systems Biology, University of Pittsburgh mchikina@pitt.edu nclark@pitt.edu.
[Ti] Título:Hundreds of Genes Experienced Convergent Shifts in Selective Pressure in Marine Mammals.
[So] Source:Mol Biol Evol;33(9):2182-92, 2016 Sep.
[Is] ISSN:1537-1719
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Mammal species have made the transition to the marine environment several times, and their lineages represent one of the classical examples of convergent evolution in morphological and physiological traits. Nevertheless, the genetic mechanisms of their phenotypic transition are poorly understood, and investigations into convergence at the molecular level have been inconclusive. While past studies have searched for convergent changes at specific amino acid sites, we propose an alternative strategy to identify those genes that experienced convergent changes in their selective pressures, visible as changes in evolutionary rate specifically in the marine lineages. We present evidence of widespread convergence at the gene level by identifying parallel shifts in evolutionary rate during three independent episodes of mammalian adaptation to the marine environment. Hundreds of genes accelerated their evolutionary rates in all three marine mammal lineages during their transition to aquatic life. These marine-accelerated genes are highly enriched for pathways that control recognized functional adaptations in marine mammals, including muscle physiology, lipid-metabolism, sensory systems, and skin and connective tissue. The accelerations resulted from both adaptive evolution as seen in skin and lung genes, and loss of function as in gustatory and olfactory genes. In regard to sensory systems, this finding provides further evidence that reduced senses of taste and smell are ubiquitous in marine mammals. Our analysis demonstrates the feasibility of identifying genes underlying convergent organism-level characteristics on a genome-wide scale and without prior knowledge of adaptations, and provides a powerful approach for investigating the physiological functions of mammalian genes.
[Mh] Termos MeSH primário: Adaptação Fisiológica/genética
Caniformia/genética
Cetáceos/genética
Interação Gene-Ambiente
Sirênios/genética
[Mh] Termos MeSH secundário: Animais
Organismos Aquáticos/genética
Evolução Biológica
Evolução Molecular
Taxa de Mutação
Fenótipo
Filogenia
Seleção Genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160623
[St] Status:MEDLINE
[do] DOI:10.1093/molbev/msw112


  2 / 26 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:26923825
[Au] Autor:Anné J; Wogelius RA; Edwards NP; van Veelen A; Ignatyev K; Manning PL
[Ad] Endereço:University of Manchester, School of Earth, Atmospheric and Environmental Sciences, Williamson Research Centre for Molecular Environmental Science, Manchester M13 9PL, UK. jennifer.anne@manchester.ac.uk and University of Manchester, Interdisciplinary Centre for Ancient Life, Manchester, M13 9PL, UK.
[Ti] Título:Chemistry of bone remodelling preserved in extant and fossil Sirenia.
[So] Source:Metallomics;8(5):508-13, 2016 May 01.
[Is] ISSN:1756-591X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Bone remodelling is a crucial biological process needed to maintain elemental homeostasis. It is important to understand the trace elemental inventories that govern these processes as malfunctions in bone remodelling can have devastating effects on an organism. In this study, we use a combination of X-ray techniques to map, quantify, and characterise the coordination chemistry of trace elements within the highly remodelled bone tissues of extant and extinct Sirenia (manatees and dugongs). The dense bone structure and unique body chemistry of sirenians represent ideal tissues for studying both high remodelling rates as well as unique fossilisation pathways. Here, elemental maps revealed uncorrelated patterning of Ca and Zn within secondary osteons in both extant and fossil sirenians, as well as elevated Sr within the connecting canals of fossil sirenians. Concentrations of these elements are comparable between extant and fossil material indicating geochemical processing of the fossil bone has been minimal. Zn was found to be bound in the same coordination within the apatite structure in both extant and fossil bone. Accurate quantification of trace elements in extant material was only possible when the organic constituents of the bone were included. The comparable distributions, concentrations, and chemical coordination of these physiologically important trace elements indicate the chemistry of bone remodelling has been preserved for 19 million years. This study signifies the powerful potential of merging histological and chemical techniques in the understanding of physiological processes in both extant and extinct vertebrates.
[Mh] Termos MeSH primário: Fósseis
Sirênios
[Mh] Termos MeSH secundário: Animais
Remodelação Óssea
Síncrotrons
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171109
[Lr] Data última revisão:
171109
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160301
[St] Status:MEDLINE
[do] DOI:10.1039/c5mt00311c


  3 / 26 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
PubMed Central Texto completo
Texto completo
[PMID]:26843552
[Au] Autor:Pyenson ND; Parham JF; Velez-Juarbe J
[Ad] Endereço:Department of Paleobiology, National Museum of Natural History, Smithsonian Institution, PO Box 37012, Washington, DC 20013-7013, USA pyensonn@si.edu.
[Ti] Título:The dilemma of trade samples and the importance of museum vouchers--caveats from a study on the extinction of Steller's sea cow: a comment on Crerar et al. (2014).
[So] Source:Biol Lett;12(2):20150149, 2016 Feb.
[Is] ISSN:1744-957X
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Extinção Biológica
Sirênios/fisiologia
[Mh] Termos MeSH secundário: Animais
[Pt] Tipo de publicação:COMMENT; JOURNAL ARTICLE
[Em] Mês de entrada:1606
[Cu] Atualização por classe:160319
[Lr] Data última revisão:
160319
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160205
[St] Status:MEDLINE


  4 / 26 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:26843553
[Au] Autor:Crerar L; Parsons EC; Domning D
[Ad] Endereço:Biology, George Mason University, 4400 University Drive, Exploratory Hall 1218, MSN: 3E1, Fairfax, VA, USA lcrerar@gmu.edu.
[Ti] Título:Serendipity in research--investigation into illegal wildlife trade discovers a new population of Steller's sea cows: a reply to Pyenson et al. (2016).
[So] Source:Biol Lett;12(2):20150670, 2016 02.
[Is] ISSN:1744-957X
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Extinção Biológica
Sirênios/fisiologia
[Mh] Termos MeSH secundário: Animais
[Pt] Tipo de publicação:JOURNAL ARTICLE; COMMENT
[Em] Mês de entrada:1606
[Cu] Atualização por classe:170504
[Lr] Data última revisão:
170504
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160205
[St] Status:MEDLINE


  5 / 26 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:26050523
[Au] Autor:Springer MS; Signore AV; Paijmans JL; Vélez-Juarbe J; Domning DP; Bauer CE; He K; Crerar L; Campos PF; Murphy WJ; Meredith RW; Gatesy J; Willerslev E; MacPhee RD; Hofreiter M; Campbell KL
[Ad] Endereço:Department of Biology, University of California, Riverside, CA 92521, USA. Electronic address: mark.springer@ucr.edu.
[Ti] Título:Interordinal gene capture, the phylogenetic position of Steller's sea cow based on molecular and morphological data, and the macroevolutionary history of Sirenia.
[So] Source:Mol Phylogenet Evol;91:178-93, 2015 Oct.
[Is] ISSN:1095-9513
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The recently extinct (ca. 1768) Steller's sea cow (Hydrodamalis gigas) was a large, edentulous North Pacific sirenian. The phylogenetic affinities of this taxon to other members of this clade, living and extinct, are uncertain based on previous morphological and molecular studies. We employed hybridization capture methods and second generation sequencing technology to obtain >30kb of exon sequences from 26 nuclear genes for both H. gigas and Dugong dugon. We also obtained complete coding sequences for the tooth-related enamelin (ENAM) gene. Hybridization probes designed using dugong and manatee sequences were both highly effective in retrieving sequences from H. gigas (mean=98.8% coverage), as were more divergent probes for regions of ENAM (99.0% coverage) that were designed exclusively from a proboscidean (African elephant) and a hyracoid (Cape hyrax). New sequences were combined with available sequences for representatives of all other afrotherian orders. We also expanded a previously published morphological matrix for living and fossil Sirenia by adding both new taxa and nine new postcranial characters. Maximum likelihood and parsimony analyses of the molecular data provide robust support for an association of H. gigas and D. dugon to the exclusion of living trichechids (manatees). Parsimony analyses of the morphological data also support the inclusion of H. gigas in Dugongidae with D. dugon and fossil dugongids. Timetree analyses based on calibration density approaches with hard- and soft-bounded constraints suggest that H. gigas and D. dugon diverged in the Oligocene and that crown sirenians last shared a common ancestor in the Eocene. The coding sequence for the ENAM gene in H. gigas does not contain frameshift mutations or stop codons, but there is a transversion mutation (AG to CG) in the acceptor splice site of intron 2. This disruption in the edentulous Steller's sea cow is consistent with previous studies that have documented inactivating mutations in tooth-specific loci of a variety of edentulous and enamelless vertebrates including birds, turtles, aardvarks, pangolins, xenarthrans, and baleen whales. Further, branch-site dN/dS analyses provide evidence for positive selection in ENAM on the stem dugongid branch where extensive tooth reduction occurred, followed by neutral evolution on the Hydrodamalis branch. Finally, we present a synthetic evolutionary tree for living and fossil sirenians showing several key innovations in the history of this clade including character state changes that parallel those that occurred in the evolutionary history of cetaceans.
[Mh] Termos MeSH primário: Sirênios/classificação
[Mh] Termos MeSH secundário: Animais
Evolução Biológica
Proteínas do Esmalte Dentário/genética
Fósseis
Genes
Filogenia
Análise de Sequência de DNA
Sirênios/anatomia & histologia
Sirênios/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (Dental Enamel Proteins); 0 (tuftelin)
[Em] Mês de entrada:1604
[Cu] Atualização por classe:150709
[Lr] Data última revisão:
150709
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150609
[St] Status:MEDLINE


  6 / 26 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
PubMed Central Texto completo
Texto completo
[PMID]:25428930
[Au] Autor:Crerar LD; Crerar AP; Domning DP; Parsons EC
[Ad] Endereço:Department of Biology, George Mason University, Fairfax, VA 22030, USA lcrerar@gmu.edu.
[Ti] Título:Rewriting the history of an extinction-was a population of Steller's sea cows (Hydrodamalis gigas) at St Lawrence Island also driven to extinction?
[So] Source:Biol Lett;10(11):20140878, 2014 Nov.
[Is] ISSN:1744-957X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The Kommandorskiye Islands population of Steller's sea cow (Hydrodamalis gigas) was extirpated ca 1768 CE. Until now, Steller's sea cow was thought to be restricted in historic times to Bering and Copper Islands, Russia, with other records in the last millennium from the western Aleutian Islands. However, Steller's sea cow bone has been obtained by the authors from St Lawrence Island, Alaska, which is significantly further north. Bone identity was verified using analysis of mitochondrial DNA. The nitrogen-15 (δ(15)N)/carbon-13 (δ(13)C) values for bone samples from St Lawrence Island were significantly (p ≤ 0.05) different from Bering Island samples, indicating a second population. Bone samples were dated to between 1030 and 1150 BP (approx. 800-920 CE). The samples date from close to the beginning of the mediaeval warm period, which could indicate that the population at St Lawrence Island was driven to extinction by climate change. A warming of the climate in the area may have changed the availability of kelp; alternatively or in addition, the animals may have been driven to extinction by the expansion of the Inuit from the Bering Strait region, possibly due to opening waterways, maybe following bowhead whales (Balaena mysticetus), or searching for iron and copper. This study provides evidence for a previously unknown population of sea cows in the North Pacific within the past 1000 years and a second Steller's sea cow extirpation event in recent history.
[Mh] Termos MeSH primário: Extinção Biológica
Sirênios/fisiologia
[Mh] Termos MeSH secundário: Alaska
Animais
Mudança Climática
DNA Mitocondrial/genética
Dados de Sequência Molecular
Análise de Sequência de DNA
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Mitochondrial)
[Em] Mês de entrada:1507
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141128
[St] Status:MEDLINE


  7 / 26 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:25339599
[Au] Autor:Buchholtz EA; Wayrynen KL; Lin IW
[Ad] Endereço:Department of Biological Sciences, Wellesley College, Wellesley, MA 02481, USA.
[Ti] Título:Breaking constraint: axial patterning in Trichechus (Mammalia: Sirenia).
[So] Source:Evol Dev;16(6):382-93, 2014 Nov-Dec.
[Is] ISSN:1525-142X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Meristic variation is often limited in serially homologous systems with high internal differentiation and high developmental modularity. The mammalian neck, an extreme example, has a fixed (at seven) count of diversely specialized segments. Imposition of the mammalian cervical constraint has been tentatively linked to the origin of the diaphragm, which is muscularized by cells that migrate from cervical somites during development. With six cervical vertebrae, the genus Trichechus (manatee) has apparently broken this constraint, although the mechanism of constraint escape is unknown. Hypotheses for the developmental origin of Trichechus cervical morphology include cervical rib 7 repatterning, a primaxial/abaxial patterning shift, and local homeosis at the cervical/thoracic boundary. We tested predictions of these hypotheses by documenting vertebral morphology, axial ossification patterns, regionalization of the postcranial skeleton, and the relationship of thoracic ribs to sternal subunits in a large data set of fetal and adult Trichechus and Dugong specimens. These observations forced rejection of all three hypotheses. We propose alternatively that a global slowing of the rate of somitogenesis reduced somite count and disrupted alignment of Hox-generated anatomical markers relative to somite (and vertebral) boundaries throughout the Trichechus column. This hypothesis is consistent with observations of the full range of traditional cervical morphologies in the six cervical vertebrae, conserved postcranial proportions, and column-wide reduction in count relative to its sister taxon, Dugong. It also suggests that the origin of the mammalian cervical constraint lies in patterning, not in count, and that Trichechus and the tree sloths have broken the constraint using different developmental mechanisms.
[Mh] Termos MeSH primário: Sirênios/embriologia
Coluna Vertebral/embriologia
[Mh] Termos MeSH secundário: Animais
Evolução Biológica
Padronização Corporal
Osteogênese
Sirênios/genética
Sirênios/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1501
[Cu] Atualização por classe:141124
[Lr] Data última revisão:
141124
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141024
[St] Status:MEDLINE
[do] DOI:10.1111/ede.12103


  8 / 26 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
PubMed Central Texto completo
Texto completo
[PMID]:23342128
[Au] Autor:Benoit J; Adnet S; El Mabrouk E; Khayati H; Ben Haj Ali M; Marivaux L; Merzeraud G; Merigeaud S; Vianey-Liaud M; Tabuce R
[Ad] Endereço:Institut des Sciences de l'Evolution, Université Montpellier 2, Montpellier, France. Julien.benoit@univ-montp2.fr
[Ti] Título:Cranial remain from Tunisia provides new clues for the origin and evolution of Sirenia (Mammalia, Afrotheria) in Africa.
[So] Source:PLoS One;8(1):e54307, 2013.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Sea cows (manatees, dugongs) are the only living marine mammals to feed solely on aquatic plants. Unlike whales or dolphins (Cetacea), the earliest evolutionary history of sirenians is poorly documented, and limited to a few fossils including skulls and skeletons of two genera composing the stem family of Prorastomidae (Prorastomus and Pezosiren). Surprisingly, these fossils come from the Eocene of Jamaica, while stem Hyracoidea and Proboscidea--the putative sister-groups to Sirenia--are recorded in Africa as early as the Late Paleocene. So far, the historical biogeography of early Sirenia has remained obscure given this paradox between phylogeny and fossil record. Here we use X-ray microtomography to investigate a newly discovered sirenian petrosal from the Eocene of Tunisia. This fossil represents the oldest occurrence of sirenians in Africa. The morphology of this petrosal is more primitive than the Jamaican prorastomids' one, which emphasizes the basal position of this new African taxon within the Sirenia clade. This discovery testifies to the great antiquity of Sirenia in Africa, and therefore supports their African origin. While isotopic analyses previously suggested sirenians had adapted directly to the marine environment, new paleoenvironmental evidence suggests that basal-most sea cows were likely restricted to fresh waters.
[Mh] Termos MeSH primário: Evolução Biológica
Sirênios/classificação
Crânio/anatomia & histologia
[Mh] Termos MeSH secundário: África
Animais
Mamíferos
Sirênios/anatomia & histologia
Tunísia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1308
[Cu] Atualização por classe:150219
[Lr] Data última revisão:
150219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130124
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0054307


  9 / 26 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:22868637
[Au] Autor:Svartman M; Stanyon R
[Ad] Endereço:Departamento de Biologia Geral, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. svartmanm@hotmail.com
[Ti] Título:The chromosomes of Afrotheria and their bearing on mammalian genome evolution.
[So] Source:Cytogenet Genome Res;137(2-4):144-53, 2012.
[Is] ISSN:1424-859X
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Afrotheria is the clade of placental mammals that, together with Xenarthra, Euarchontoglires and Laurasiatheria, represents 1 of the 4 main recognized supraordinal eutherian clades. It reunites 6 orders of African origin: Proboscidea, Sirenia, Hyracoidea, Macroscelidea, Afrosoricida and Tubulidentata. The apparently unlikely relationship among such disparate morphological taxa and their possible basal position at the base of the eutherian phylogenetic tree led to a great deal of attention and research on the group. The use of biomolecular data was pivotal in Afrotheria studies, as they were the basis for the recognition of this clade. Although morphological evidence is still scarce, a plethora of molecular data firmly attests to the phylogenetic relationship among these mammals of African origin. Modern cytogenetic techniques also gave a significant contribution to the study of Afrotheria, revealing chromosome signatures for the group as a whole, as well as for some of its internal relationships. The associations of human chromosomes HSA1/19 and 5/21 were found to be chromosome signatures for the group and provided further support for Afrotheria. Additional chromosome synapomorphies were also identified linking elephants and manatees in Tethytheria (the associations HSA2/3, 3/13, 8/22, 18/19 and the lack of HSA4/8) and elephant shrews with the aardvark (HSA2/8, 3/20 and 10/17). Herein, we review the current knowledge on Afrotheria chromosomes and genome evolution. The already available data on the group suggests that further work on this apparently bizarre assemblage of mammals will provide important data to a better understanding on mammalian genome evolution.
[Mh] Termos MeSH primário: Cromossomos de Mamíferos/genética
Evolução Molecular
Mamíferos/classificação
Mamíferos/genética
[Mh] Termos MeSH secundário: África
Animais
Bandeamento Cromossômico
Análise Citogenética
Diploide
Feminino
Seres Humanos
Dassies/classificação
Dassies/genética
Masculino
Filogenia
Mamíferos Proboscídeos/classificação
Mamíferos Proboscídeos/genética
Sirênios/classificação
Sirênios/genética
Xenartros/classificação
Xenartros/genética
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Em] Mês de entrada:1211
[Cu] Atualização por classe:120905
[Lr] Data última revisão:
120905
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120808
[St] Status:MEDLINE
[do] DOI:10.1159/000341387


  10 / 26 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:22777871
[Au] Autor:Beatty BL; Vitkovski T; Lambert O; Macrini TE
[Ad] Endereço:New York College of Osteopathic Medicine, Old Westbury, New York, USA. bbeaty@nyit.edu
[Ti] Título:Osteological associations with unique tooth development in manatees (Trichechidae, Sirenia): a detailed look at modern Trichechus and a review of the fossil record.
[So] Source:Anat Rec (Hoboken);295(9):1504-12, 2012 Sep.
[Is] ISSN:1932-8494
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Modern manatees have a unique type of tooth development, continually forming identical new molars in the posterior end of each quadrant of their mouths, and then progressively moving teeth anteriorly, only to reabsorb roots and spit out worn crowns. This process is not only developmentally complex, but requires space in the oral cavity that imposes its own limitations on other uses of that space. To gain a clearer understanding of the anatomical constraints on the evolution of this unique developmental process, we identified the specialized craniodental features in modern Trichechus that permit this specialization using visual observation and CT. Furthermore, to better understand the evolution of these traits, we review the fossil record of trichechids for these traits, including CT analysis of the skull of Miosiren kocki, a possible early member of the family from the Early Miocene of Belgium.
[Mh] Termos MeSH primário: Evolução Biológica
Fósseis
Odontogênese/fisiologia
Dente/crescimento & desenvolvimento
Trichechus/crescimento & desenvolvimento
[Mh] Termos MeSH secundário: Animais
Filogenia
Sirênios/genética
Sirênios/crescimento & desenvolvimento
Trichechus/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Em] Mês de entrada:1306
[Cu] Atualização por classe:120817
[Lr] Data última revisão:
120817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120711
[St] Status:MEDLINE
[do] DOI:10.1002/ar.22525



página 1 de 3 ir para página          
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde