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  1 / 153 MEDLINE  
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[PMID]:28052333
[Au] Autor:Hansen VL; Miller RD
[Ad] Endereço:Department of Biology, Center for Evolutionary and Theoretical Immunology, University of New Mexico, Albuquerque, NM, USA.
[Ti] Título:On the prenatal initiation of T cell development in the opossum Monodelphis domestica.
[So] Source:J Anat;230(4):596-600, 2017 Apr.
[Is] ISSN:1469-7580
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Thymus-dependent lymphocytes (T cells) are a critical cell lineage in the adaptive immune system of all jawed vertebrates. In eutherian mammals the initiation of T cell development takes place prenatally and the offspring of many species are born relatively immuno-competent. Marsupials, in contrast, are born in a comparatively altricial state and with a less well developed immune system. As such, marsupials are valuable models for studying the peri- and postnatal initiation of immune system development in mammals. Previous results supported a lack of prenatal T cell development in a variety of marsupial species. In the gray short-tailed opossum, Monodelphis domestica, however, there was evidence that αßT cells were present on postnatal day 1 and likely initiated development prenatally. Demonstrated here is the presence of CD3ε lymphocytes in late-stage embryos at a site in the upper thoracic cavity, the site of an early developing thymus. CD3ε cells were evident as early as 48 h prior to parturition. In day 14 embryos, where there is clear organogenesis, CD3ε cells were only found at the site of the early thymus, consistent with no extra-thymic sites of T cell development in the opossum. These observations are the first evidence of prenatal T cell lineage commitment in any marsupial.
[Mh] Termos MeSH primário: Monodelphis/embriologia
Linfócitos T
[Mh] Termos MeSH secundário: Animais
Animais Recém-Nascidos
Feminino
Monodelphis/anatomia & histologia
Gravidez
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170904
[Lr] Data última revisão:
170904
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170105
[St] Status:MEDLINE
[do] DOI:10.1111/joa.12587


  2 / 153 MEDLINE  
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[PMID]:27852732
[Au] Autor:Dooley JC; Donaldson MS; Krubitzer LA
[Ad] Endereço:Center for Neuroscience, University of California, Davis, Davis, California; and.
[Ti] Título:Cortical plasticity following stripe rearing in the marsupial Monodelphis domestica: neural response properties of V1.
[So] Source:J Neurophysiol;117(2):566-581, 2017 Feb 01.
[Is] ISSN:1522-1598
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The functional organization of the primary visual area (V1) and the importance of sensory experience in its normal development have been well documented in eutherian mammals. However, very few studies have investigated the response properties of V1 neurons in another large class of mammals, or whether sensory experience plays a role in shaping their response properties. Thus we reared opossums (Monodelphis domestica) in normal and vertically striped cages until they reached adulthood. They were then anesthetized using urethane, and electrophysiological techniques were used to examine neuronal responses to different orientations, spatial and temporal frequencies, and contrast levels. For normal opossums, we observed responses to the temporal and spatial characteristics of the stimulus to be similar to those described in small, nocturnal, eutherian mammals such as rats and mice; neurons in V1 responded maximally to stimuli at 0.09 cycles per degree and 2.12 cycles per second. Unlike other eutherians, but similar to other marsupials investigated, only 40% of the neurons were orientation selective. In stripe-reared animals, neurons were significantly more likely to respond to vertical stimuli at a wider range of spatial frequencies, and were more sensitive to gratings at lower contrast values compared with normal animals. These results are the first to demonstrate experience-dependent plasticity in the visual system of a marsupial species. Thus the ability of cortical neurons to alter their properties based on the dynamics of the visual environment predates the emergence of eutherian mammals and was likely present in our earliest mammalian ancestors. NEW & NOTEWORTHY: These results are the first description of visual response properties of the most commonly studied marsupial model organism, the short-tailed opossum (Monodelphis domestica). Further, these results are the first to demonstrate experience-dependent plasticity in the visual system of a marsupial species. Thus the ability of cortical neurons to alter their properties based on the dynamics of the visual environment predates the emergence of eutherian mammals and was likely present in our earliest mammalian ancestors.
[Mh] Termos MeSH primário: Adaptação Fisiológica/fisiologia
Plasticidade Neuronal/fisiologia
Neurônios/fisiologia
Córtex Visual/citologia
Percepção Visual/fisiologia
[Mh] Termos MeSH secundário: Potenciais de Ação/fisiologia
Animais
Biofísica
Mapeamento Encefálico
Feminino
Masculino
Monodelphis
Estimulação Luminosa
Fatores de Tempo
Campos Visuais/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170920
[Lr] Data última revisão:
170920
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161118
[St] Status:MEDLINE
[do] DOI:10.1152/jn.00431.2016


  3 / 153 MEDLINE  
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[PMID]:27832604
[Au] Autor:Headley DB; Kanta V; Paré D
[Ad] Endereço:Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, Newark, New Jersey.
[Ti] Título:Intra- and interregional cortical interactions related to sharp-wave ripples and dentate spikes.
[So] Source:J Neurophysiol;117(2):556-565, 2017 Feb 01.
[Is] ISSN:1522-1598
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The hippocampus generates population events termed sharp-wave ripples (SWRs) and dentate spikes (DSs). While little is known about DSs, SWR-related hippocampal discharges during sleep are thought to replay prior waking activity, reactivating the cortical networks that encoded the initial experience. During slow-wave sleep, such reactivations likely occur during up-states, when most cortical neurons are depolarized. However, most studies have examined the relationship between SWRs and up-states measured in single neocortical regions. As a result, it is currently unclear whether SWRs are associated with particular patterns of widely distributed cortical activity. Additionally, no such investigation has been carried out for DSs. The present study addressed these questions by recording SWRs and DSs from the dorsal hippocampus simultaneously with prefrontal, sensory (visual and auditory), perirhinal, and entorhinal cortices in naturally sleeping rats. We found that SWRs and DSs were associated with up-states in all cortical regions. Up-states coinciding with DSs and SWRs exhibited increased unit activity, power in the gamma band, and intraregional gamma coherence. Unexpectedly, interregional gamma coherence rose much more strongly in relation to DSs than to SWRs. Whereas the increase in gamma coherence was time locked to DSs, that seen in relation to SWRs was not. These observations suggest that SWRs are related to the strength of up-state activation within individual regions throughout the neocortex but not so much to gamma coherence between different regions. Perhaps more importantly, DSs coincided with stronger periods of interregional gamma coherence, suggesting that they play a more important role than previously assumed. NEW & NOTEWORTHY: Off-line cortico-hippocampal interactions are thought to support memory consolidation. We surveyed the relationship between hippocampal sharp-wave ripples (SWRs) and dentate spikes (DSs) with up-states across multiple cortical regions. SWRs and DSs were associated with increased cortical gamma oscillations. Interregional gamma coherence rose much more strongly in relation to DSs than to SWRs. Moreover, it was time locked to DSs but not SWRs. These results have important implications for current theories of systems memory consolidation during sleep.
[Mh] Termos MeSH primário: Potenciais de Ação/fisiologia
Giro Denteado/citologia
Neurônios/fisiologia
Córtex Visual/citologia
Córtex Visual/fisiologia
Percepção Visual/fisiologia
[Mh] Termos MeSH secundário: Animais
Mapeamento Encefálico
Sensibilidades de Contraste/fisiologia
Feminino
Masculino
Monodelphis/fisiologia
Rede Nervosa/fisiologia
Orientação
Estimulação Luminosa
Isolamento Social
Percepção Espacial
Campos Visuais/fisiologia
Vias Visuais/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170920
[Lr] Data última revisão:
170920
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161111
[St] Status:MEDLINE
[do] DOI:10.1152/jn.00644.2016


  4 / 153 MEDLINE  
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[PMID]:27784721
[Au] Autor:Porto A; Schmelter R; VandeBerg JL; Marroig G; Cheverud JM
[Ad] Endereço:Department of Biology, Washington University in St Louis, Missouri 63130 arthur.porto@utrgv.edu.
[Ti] Título:Evolution of the Genotype-to-Phenotype Map and the Cost of Pleiotropy in Mammals.
[So] Source:Genetics;204(4):1601-1612, 2016 Dec.
[Is] ISSN:1943-2631
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Evolutionary studies have long emphasized that the genetic architecture of traits holds important microevolutionary consequences. Yet, studies comparing the genetic architecture of traits across species are rare, and discussions of the evolution of genetic systems are made on theoretical arguments rather than on empirical evidence. Here, we compared the genetic architecture of cranial traits in two different mammalian model organisms: the gray short-tailed opossum, Monodelphis domestica, and the laboratory mouse, Mus musculus We show that both organisms share a highly polygenic genetic architecture for craniofacial traits, with many loci of small effect. However, these two model species differ significantly in the overall degree of pleiotropy, N, of the genotype-to-phenotype map, with opossums presenting a higher average N They also diverge in their degree of genetic modularity, with opossums presenting less modular patterns of genetic association among traits. We argue that such differences highlight the context dependency of gene effects, with developmental systems shaping the variational properties of genetic systems. Finally, we also demonstrate based on the opossum data that current measurements for the relationship between the mutational effect size and N need to be re-evaluated in relation to the importance of the cost of pleiotropy for mammals.
[Mh] Termos MeSH primário: Evolução Molecular
Pleiotropia Genética
Genótipo
[Mh] Termos MeSH secundário: Animais
Camundongos
Modelos Genéticos
Monodelphis/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170526
[Lr] Data última revisão:
170526
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161028
[St] Status:MEDLINE


  5 / 153 MEDLINE  
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[PMID]:27315396
[Au] Autor:Cornelis G; Souquere S; Vernochet C; Heidmann T; Pierron G
[Ad] Endereço:a CNRS-UMR-9196 , Institut Gustave Roussy , 94805 Villejuif , France.
[Ti] Título:Functional conservation of the lncRNA NEAT1 in the ancestrally diverged marsupial lineage: Evidence for NEAT1 expression and associated paraspeckle assembly during late gestation in the opossum Monodelphis domestica.
[So] Source:RNA Biol;13(9):826-36, 2016 Sep.
[Is] ISSN:1555-8584
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Long non-coding RNAs (lncRNAs) are widely expressed and play various roles in cell homeostasis. However, because of their low conservation at the sequence level, recapitulating lncRNA evolutionary history is often challenging. While performing an ultrastructural analysis of viral particles present in uterine glands of gestating opossum females, we serendipitously noticed the presence of numerous structures similar to paraspeckles, nuclear bodies which in human and mouse cells are assembled around an architectural NEAT1/MENϵ/ß lncRNA. Here, using an opossum kidney (OK) cell line, we confirmed by immuno-electron microscopy the presence of paraspeckles in marsupials. We then identified the orthologous opossum NEAT1 gene which, although poorly conserved at the sequence level, displays NEAT1 characteristic features such as short and long isoforms expressed from a unique promoter and for the latter an RNase P cleavage site at its 3'-end. Combining tissue-specific qRT-PCR, in situ hybridization at the optical and electron microscopic levels, we show that (i) NEAT1 is paraspeckle-associated in opossum (ii) NEAT1 expression is strongly induced in late gestation in uterine/placental extracts (iii) NEAT1 induction occurs in the uterine gland nuclei in which paraspeckles were detected. Finally, treatment of OK cells with proteasome inhibitors induces paraspeckle assembly, as previously observed in human cells. Altogether, these results demonstrate that paraspeckles are tissue-specific, stress-responding nuclear bodies in marsupials, illustrating their structural and functional continuity over 200 My of evolution throughout the mammalian lineage. In contrast, the rapid evolution of the NEAT1 transcripts highlights the relaxed constraint that, despite functional conservation, is exerted on this lncRNA.
[Mh] Termos MeSH primário: Evolução Molecular
Monodelphis/genética
RNA Longo não Codificante/genética
[Mh] Termos MeSH secundário: Animais
Sequência de Bases
Linhagem Celular
Núcleo Celular/genética
Núcleo Celular/metabolismo
Mapeamento Cromossômico
Expressão Gênica
Conformação de Ácido Nucleico
Especificidade de Órgãos/genética
Organogênese/genética
Isoformas de RNA
RNA Longo não Codificante/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (RNA Isoforms); 0 (RNA, Long Noncoding)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171019
[Lr] Data última revisão:
171019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160618
[St] Status:MEDLINE
[do] DOI:10.1080/15476286.2016.1197482


  6 / 153 MEDLINE  
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[PMID]:27194412
[Au] Autor:Dowling A; Doroba C; Maier JA; Cohen L; VandeBerg J; Sears KE
[Ad] Endereço:School of Integrative Biology, University of Illinois, 505 S Goodwin Avenue, Urbana, IL, 61801, USA.
[Ti] Título:Cellular and molecular drivers of differential organ growth: insights from the limbs of Monodelphis domestica.
[So] Source:Dev Genes Evol;226(3):235-43, 2016 Jun.
[Is] ISSN:1432-041X
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:A fundamental question in biology is "how is growth differentially regulated during development to produce organs of particular sizes?" We used a new model system for the study of differential organ growth, the limbs of the opossum (Monodelphis domestica), to investigate the cellular and molecular basis of differential organ growth in mammals. Opossum forelimbs grow much faster than hindlimbs, making opossum limbs an exceptional system with which to study differential growth. We first used the great differences in opossum forelimb and hindlimb growth to identify cellular processes and molecular signals that underlie differential limb growth. We then used organ culture and pharmacological addition of FGF ligands and inhibitors to test the role of the Fgf/Mitogen-activated protein kinases (MAPK) signaling pathway in driving these cellular processes. We found that molecular signals from within the limb drive differences in cell proliferation that contribute to the differential growth of the forelimb and hindlimbs of opossums. We also found that alterations in the Fgf/MAPK pathway can generate differences in cell proliferation that mirror those observed between wild-type forelimb and hindlimbs of opossums and that manipulation of Fgf/MAPK signaling affects downstream focal adhesion-extracellular matrix (FA-ECM) and Wnt signaling in opossum limbs. Taken together, these findings suggest that evolutionary changes in the Fgf/MAPK pathway could help drive the observed differences in cell behaviors and growth in opossum forelimb and hindlimbs.
[Mh] Termos MeSH primário: Membro Anterior/crescimento & desenvolvimento
Membro Posterior/crescimento & desenvolvimento
Sistema de Sinalização das MAP Quinases
Monodelphis/crescimento & desenvolvimento
[Mh] Termos MeSH secundário: Animais
Morte Celular
Proliferação Celular
Fatores de Crescimento de Fibroblastos/metabolismo
Membro Anterior/citologia
Membro Anterior/metabolismo
Membro Posterior/citologia
Membro Posterior/metabolismo
Monodelphis/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
62031-54-3 (Fibroblast Growth Factors)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171006
[Lr] Data última revisão:
171006
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160520
[St] Status:MEDLINE
[do] DOI:10.1007/s00427-016-0549-0


  7 / 153 MEDLINE  
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[PMID]:27098555
[Au] Autor:Ramamurthy DL; Krubitzer LA
[Ad] Endereço:Center for Neuroscience, University of California, Davis, Davis, California, 95618.
[Ti] Título:The evolution of whisker-mediated somatosensation in mammals: Sensory processing in barrelless S1 cortex of a marsupial, Monodelphis domestica.
[So] Source:J Comp Neurol;524(17):3587-3613, 2016 Dec 01.
[Is] ISSN:1096-9861
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Movable tactile sensors in the form of whiskers are present in most mammals, but sensory coding in the cortical whisker representation has been studied almost exclusively in mice and rats. Many species that possess whiskers lack the modular "barrel" organization found in the primary somatosensory cortex (S1) of mice and rats, but it is unclear how whisker-related input is represented in these species. We used single-unit extracellular recording techniques to characterize receptive fields and response properties in S1 of Monodelphis domestica (short-tailed opossum), a nocturnal, terrestrial marsupial that shared its last common ancestor with placental mammals over 160 million years ago. Short-tailed opossums lack barrels and septa in S1 but show active whisking behavior similar to that of mice and rats. Most neurons in short-tailed opossum S1 exhibited multiwhisker receptive fields, including a single best whisker (BW) and lower magnitude responses to the deflection of surrounding whiskers. Mean tuning width was similar to that reported for mice and rats. Both symmetrical and asymmetrical receptive fields were present. Neurons tuned to ventral whiskers tended to show broad tuning along the rostrocaudal axis. Thus, despite the absence of barrels, most receptive field properties were similar to those reported for mice and rats. However, unlike those species, S1 neuronal responses to BW and surround whisker deflection showed comparable latencies in short-tailed opossums. This dissimilarity suggests that some aspects of barrel cortex function may not generalize to tactile processing across mammalian species and may be related to differences in the architecture of the whisker-to-cortex pathway. J. Comp. Neurol. 524:3587-3613, 2016. © 2016 Wiley Periodicals, Inc.
[Mh] Termos MeSH primário: Monodelphis/fisiologia
Córtex Somatossensorial/fisiologia
Percepção do Tato/fisiologia
Vibrissas/fisiologia
[Mh] Termos MeSH secundário: Potenciais de Ação
Animais
Evolução Biológica
Western Blotting
Potenciais Somatossensoriais Evocados
Feminino
Masculino
Microeletrodos
Monodelphis/anatomia & histologia
Neurônios/fisiologia
Parvalbuminas/metabolismo
Estimulação Física
Vibrissas/anatomia & histologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Parvalbumins)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170912
[Lr] Data última revisão:
170912
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160422
[St] Status:MEDLINE
[do] DOI:10.1002/cne.24018


  8 / 153 MEDLINE  
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[PMID]:26848758
[Au] Autor:Desmarais MJ; Beauregard F; Cabana T; Pflieger JF
[Ad] Endereço:Département de sciences biologiques, Université de Montréal, Montréal, Québec, Canada.
[Ti] Título:Facial Mechanosensory Influence on Forelimb Movement in Newborn Opossums, Monodelphis domestica.
[So] Source:PLoS One;11(2):e0148352, 2016.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The opossum, Monodelphis domestica, is born very immature but crawls, unaided, with its forelimbs (FL) from the mother's birth canal to a nipple where it attaches to pursue its development. What sensory cues guide the newborn to the nipple and trigger its attachment to it? Previous experiments showed that low intensity electrical stimulation of the trigeminal ganglion induces FL movement in in vitro preparations and that trigeminal innervation of the facial skin is well developed in the newborn. The skin does not contain Vater-Pacini or Meissner touch corpuscles at this age, but it contains cells which appear to be Merkel cells (MC). We sought to determine if touch perceived by MC could exert an influence on FL movements. Application of the fluorescent dye AM1-43, which labels sensory cells such as MC, revealed the presence of a large number of labeled cells in the facial epidermis, especially in the snout skin, in newborn opossums. Moreover, calibrated pressure applied to the snout induced bilateral and simultaneous electromyographic responses of the triceps muscle in in vitro preparations of the neuraxis and FL from newborn. These responses increase with stimulation intensity and tend to decrease over time. Removing the facial skin nearly abolished these responses. Metabotropic glutamate 1 receptors being involved in MC neurotransmission, an antagonist of these receptors was applied to the bath, which decreased the EMG responses in a reversible manner. Likewise, bath application of the purinergic type 2 receptors, used by AM1-43 to penetrate sensory cells, also decreased the triceps EMG responses. The combined results support a strong influence of facial mechanosensation on FL movement in newborn opossums, and suggest that this influence could be exerted via MC.
[Mh] Termos MeSH primário: Face/fisiologia
Membro Anterior/fisiologia
Mecanotransdução Celular
Monodelphis
Movimento/fisiologia
[Mh] Termos MeSH secundário: Animais
Animais Recém-Nascidos
Epiderme/citologia
Feminino
Masculino
Compostos de Piridínio/metabolismo
Compostos de Amônio Quaternário/metabolismo
Receptores Purinérgicos P2/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (AM1-43 compound); 0 (Pyridinium Compounds); 0 (Quaternary Ammonium Compounds); 0 (Receptors, Purinergic P2)
[Em] Mês de entrada:1607
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160206
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0148352


  9 / 153 MEDLINE  
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[PMID]:26792006
[Au] Autor:Bazwinsky-Wutschke I; Härtig W; Kretzschmar R; Rübsamen R
[Ad] Endereço:Institute of Biology, University of Leipzig, 04103, Leipzig, Germany. ivonne.bazwinsky@medizin.uni-halle.de.
[Ti] Título:Differential morphology of the superior olivary complex of Meriones unguiculatus and Monodelphis domestica revealed by calcium-binding proteins.
[So] Source:Brain Struct Funct;221(9):4505-4523, 2016 Dec.
[Is] ISSN:1863-2661
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:In mammals, the superior olivary complex (SOC) of the brainstem is composed of nuclei that integrate afferent auditory originating from both ears. Here, the expression of different calcium-binding proteins in subnuclei of the SOC was studied in distantly related mammals, the Mongolian gerbil (Meriones unguiculatus) and the gray short-tailed opossum (Monodelphis domestica) to get a better understanding of the basal nuclear organization of the SOC. Combined immunofluorescence labeling of the calcium-binding proteins (CaBPs) parvalbumin, calbindin-D28k, and calretinin as well as pan-neuronal markers displayed characteristic distribution patterns highlighting details of neuronal architecture of SOC nuclei. Parvalbumin was found in almost all neurons of SOC nuclei in both species, while calbindin and calretinin were restricted to specific cell types and axonal terminal fields. In both species, calbindin displayed a ubiquitous and mostly selective distribution in neurons of the medial nucleus of trapezoid body (MNTB) including their terminal axonal fields in different SOC targets. In Meriones, calretinin and calbindin showed non-overlapping expression patterns in neuron somata and terminal fields throughout the SOC. In Monodelphis, co-expression of calbindin and calretinin was observed in the MNTB, and hence both CaBPs were also co-localized in terminal fields within the adjacent SOC nuclei. The distribution patterns of CaBPs in both species are discussed with respect to the intrinsic neuronal SOC circuits as part of the auditory brainstem system that underlie the binaural integrative processing of acoustic signals as the basis for localization and discrimination of auditory objects.
[Mh] Termos MeSH primário: Proteínas de Ligação ao Cálcio/metabolismo
Gerbillinae/anatomia & histologia
Monodelphis/anatomia & histologia
Neurônios/citologia
Complexo Olivar Superior/citologia
[Mh] Termos MeSH secundário: Animais
Vias Auditivas/citologia
Vias Auditivas/metabolismo
Calbindina 2/metabolismo
Calbindinas/metabolismo
Feminino
Gerbillinae/metabolismo
Masculino
Monodelphis/metabolismo
Neurônios/metabolismo
Parvalbuminas/metabolismo
Especificidade da Espécie
Complexo Olivar Superior/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Calbindin 2); 0 (Calbindins); 0 (Calcium-Binding Proteins); 0 (Parvalbumins)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160122
[St] Status:MEDLINE


  10 / 153 MEDLINE  
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[PMID]:26732839
[Au] Autor:Nomura T; Ohtaka-Maruyama C; Yamashita W; Wakamatsu Y; Murakami Y; Calegari F; Suzuki K; Gotoh H; Ono K
[Ad] Endereço:Developmental Neurobiology, Kyoto Prefectural University of Medicine, INAMORI Memorial Building, 1-5 Shimogamo-hangi cho, Sakyo-ku, Kyoto 606-0823, Japan Japan Science and Technology Agency (JST), PRESTO, 4-1-8 Honcho, Kawaguchi, Saitama 332-0012, Japan tadnom@koto.kpu-m.ac.jp.
[Ti] Título:The evolution of basal progenitors in the developing non-mammalian brain.
[So] Source:Development;143(1):66-74, 2016 Jan 01.
[Is] ISSN:1477-9129
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The amplification of distinct neural stem/progenitor cell subtypes during embryogenesis is essential for the intricate brain structures present in various vertebrate species. For example, in both mammals and birds, proliferative neuronal progenitors transiently appear on the basal side of the ventricular zone of the telencephalon (basal progenitors), where they contribute to the enlargement of the neocortex and its homologous structures. In placental mammals, this proliferative cell population can be subdivided into several groups that include Tbr2(+) intermediate progenitors and basal radial glial cells (bRGs). Here, we report that basal progenitors in the developing avian pallium show unique morphological and molecular characteristics that resemble the characteristics of bRGs, a progenitor population that is abundant in gyrencephalic mammalian neocortex. Manipulation of LGN (Leu-Gly-Asn repeat-enriched protein) and Cdk4/cyclin D1, both essential regulators of neural progenitor dynamics, revealed that basal progenitors and Tbr2(+) cells are distinct cell lineages in the developing avian telencephalon. Furthermore, we identified a small population of subapical mitotic cells in the developing brains of a wide variety of amniotes and amphibians. Our results suggest that unique progenitor subtypes are amplified in mammalian and avian lineages by modifying common mechanisms of neural stem/progenitor regulation during amniote brain evolution.
[Mh] Termos MeSH primário: Gânglios da Base/citologia
Gânglios da Base/embriologia
Neocórtex/embriologia
Células-Tronco Neurais/citologia
Neurônios/citologia
[Mh] Termos MeSH secundário: Ambystoma mexicanum
Animais
Linhagem da Célula/fisiologia
Proliferação Celular/fisiologia
Embrião de Galinha
Ciclina D1/metabolismo
Quinase 4 Dependente de Ciclina/metabolismo
Regulação da Expressão Gênica no Desenvolvimento
Camundongos
Monodelphis/embriologia
Neocórtex/citologia
Tartarugas/embriologia
Xenopus laevis
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
136601-57-5 (Cyclin D1); EC 2.7.11.22 (Cyclin-Dependent Kinase 4)
[Em] Mês de entrada:1607
[Cu] Atualização por classe:160209
[Lr] Data última revisão:
160209
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160107
[St] Status:MEDLINE
[do] DOI:10.1242/dev.127100



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