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  1 / 15934 MEDLINE  
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[PMID]:28002987
[Au] Autor:Héricé C; Khalil R; Moftah M; Boraud T; Guthrie M; Garenne A
[Ad] Endereço:* University de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, 33000 Bordeaux, France.
[Ti] Título:Decision making under uncertainty in a spiking neural network model of the basal ganglia.
[So] Source:J Integr Neurosci;15(4):515-538, 2016 Dec.
[Is] ISSN:0219-6352
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The mechanisms of decision-making and action selection are generally thought to be under the control of parallel cortico-subcortical loops connecting back to distinct areas of cortex through the basal ganglia and processing motor, cognitive and limbic modalities of decision-making. We have used these properties to develop and extend a connectionist model at a spiking neuron level based on a previous rate model approach. This model is demonstrated on decision-making tasks that have been studied in primates and the electrophysiology interpreted to show that the decision is made in two steps. To model this, we have used two parallel loops, each of which performs decision-making based on interactions between positive and negative feedback pathways. This model is able to perform two-level decision-making as in primates. We show here that, before learning, synaptic noise is sufficient to drive the decision-making process and that, after learning, the decision is based on the choice that has proven most likely to be rewarded. The model is then submitted to lesion tests, reversal learning and extinction protocols. We show that, under these conditions, it behaves in a consistent manner and provides predictions in accordance with observed experimental data.
[Mh] Termos MeSH primário: Gânglios da Base/fisiologia
Tomada de Decisões/fisiologia
Modelos Neurológicos
Redes Neurais (Computação)
Incerteza
[Mh] Termos MeSH secundário: Animais
Córtex Cerebral/fisiologia
Extinção Psicológica/fisiologia
Macaca
Atividade Motora/fisiologia
Plasticidade Neuronal/fisiologia
Neurônios/fisiologia
Reversão de Aprendizagem/fisiologia
Recompensa
Sinapses/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170228
[Lr] Data última revisão:
170228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161222
[St] Status:MEDLINE
[do] DOI:10.1142/S021963521650028X


  2 / 15934 MEDLINE  
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[PMID]:27773476
[Au] Autor:Takeshita RS; Huffman MA; Mouri K; Shimizu K; Bercovitch FB
[Ad] Endereço:Department of Ecology and Social Behavior, Primate Research Institute, Kyoto University, 41-2, Kanrin, Inuyama, Aichi 484-8506, Japan. Electronic address: rafaela.takeshita.32c@st.kyoto-u.ac.jp.
[Ti] Título:Dead or alive? Predicting fetal loss in Japanese macaques (Macaca fuscata) by fecal metabolites.
[So] Source:Anim Reprod Sci;175:33-38, 2016 Dec.
[Is] ISSN:1873-2232
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Dehydroepiandrosterone-sulfate (DHEAS) is the main steroid product of the primate fetal adrenal during mid to late gestation and it plays a major role in providing estrogens needed for parturition. We tested the hypothesis that this hormone can indicate fetal health status and attempted to use fecal DHEAS (fDHEAS) to predict pregnancy outcome in Japanese macaques. The subjects were 16 adult females and 3 neonatal Japanese macaques living in captivity at the Primate Research Institute, Kyoto University. We classified females that gave birth to healthy infants as successful and females that gave birth to dead infants as stillbirth (late fetal loss) and miscarriage (early fetal loss). The remaining females did not become pregnant and were used as controls. We collected fecal samples from all cycling, pregnant, and post-pregnant females as well as the three neonates for analysis of fDHEAS, fecal estrogen (fE) and fecal progesterone (fP) by enzyme immunoassay. We found that fE and fP increased during gestation in both successful and stillbirth groups, but increased only during the first two months in the female that had a miscarriage. Levels of fDHEAS only increased in the second half of gestation in successful pregnancies. Neonates had extremely elevated concentrations of fDHEAS in comparison to post-parturition females, which confirms that DHEAS metabolites are a product of the fetal adrenal. Low DHEAS levels could be a marker of an unsuccessful pregnancy in primates. Monitoring fDHEAS levels can be useful in zoos and institute management and can be applied to wild and free-ranging populations.
[Mh] Termos MeSH primário: Aborto Animal/diagnóstico
Desidroepiandrosterona/química
Estrogênios/química
Fezes/química
Macaca/fisiologia
Progesterona/química
[Mh] Termos MeSH secundário: Animais
Animais Recém-Nascidos
Desidroepiandrosterona/metabolismo
Estrogênios/metabolismo
Feminino
Período Periparto/fisiologia
Gravidez
Progesterona/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Estrogens); 459AG36T1B (Dehydroepiandrosterone); 4G7DS2Q64Y (Progesterone)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170118
[Lr] Data última revisão:
170118
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161024
[St] Status:MEDLINE


  3 / 15934 MEDLINE  
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[PMID]:27051064
[Au] Autor:Chang C; Leopold DA; Schölvinck ML; Mandelkow H; Picchioni D; Liu X; Ye FQ; Turchi JN; Duyn JH
[Ad] Endereço:Advanced Magnetic Resonance Imaging Section, Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892; catie.chang@nih.gov.
[Ti] Título:Tracking brain arousal fluctuations with fMRI.
[So] Source:Proc Natl Acad Sci U S A;113(16):4518-23, 2016 Apr 19.
[Is] ISSN:1091-6490
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Changes in brain activity accompanying shifts in vigilance and arousal can interfere with the study of other intrinsic and task-evoked characteristics of brain function. However, the difficulty of tracking and modeling the arousal state during functional MRI (fMRI) typically precludes the assessment of arousal-dependent influences on fMRI signals. Here we combine fMRI, electrophysiology, and the monitoring of eyelid behavior to demonstrate an approach for tracking continuous variations in arousal level from fMRI data. We first characterize the spatial distribution of fMRI signal fluctuations that track a measure of behavioral arousal; taking this pattern as a template, and using the local field potential as a simultaneous and independent measure of cortical activity, we observe that the time-varying expression level of this template in fMRI data provides a close approximation of electrophysiological arousal. We discuss the potential benefit of these findings for increasing the sensitivity of fMRI as a cognitive and clinical biomarker.
[Mh] Termos MeSH primário: Nível de Alerta/fisiologia
Ondas Encefálicas/fisiologia
Encéfalo/fisiologia
Transmissão Sináptica/fisiologia
[Mh] Termos MeSH secundário: Animais
Encéfalo/diagnóstico por imagem
Macaca
Imagem por Ressonância Magnética
Radiografia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., INTRAMURAL
[Em] Mês de entrada:1609
[Cu] Atualização por classe:161126
[Lr] Data última revisão:
161126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160420
[St] Status:MEDLINE
[do] DOI:10.1073/pnas.1520613113


  4 / 15934 MEDLINE  
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[PMID]:27015604
[Au] Autor:Self MW; Peters JC; Possel JK; Reithler J; Goebel R; Ris P; Jeurissen D; Reddy L; Claus S; Baayen JC; Roelfsema PR
[Ad] Endereço:Department of Vision and Cognition, Netherlands Institute for Neuroscience, an institute of the Royal Netherlands Academy of Art and Sciences (KNAW), Amsterdam, the Netherlands.
[Ti] Título:The Effects of Context and Attention on Spiking Activity in Human Early Visual Cortex.
[So] Source:PLoS Biol;14(3):e1002420, 2016 Mar.
[Is] ISSN:1545-7885
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Here we report the first quantitative analysis of spiking activity in human early visual cortex. We recorded multi-unit activity from two electrodes in area V2/V3 of a human patient implanted with depth electrodes as part of her treatment for epilepsy. We observed well-localized multi-unit receptive fields with tunings for contrast, orientation, spatial frequency, and size, similar to those reported in the macaque. We also observed pronounced gamma oscillations in the local-field potential that could be used to estimate the underlying spiking response properties. Spiking responses were modulated by visual context and attention. We observed orientation-tuned surround suppression: responses were suppressed by image regions with a uniform orientation and enhanced by orientation contrast. Additionally, responses were enhanced on regions that perceptually segregated from the background, indicating that neurons in the human visual cortex are sensitive to figure-ground structure. Spiking responses were also modulated by object-based attention. When the patient mentally traced a curve through the neurons' receptive fields, the accompanying shift of attention enhanced neuronal activity. These results demonstrate that the tuning properties of cells in the human early visual cortex are similar to those in the macaque and that responses can be modulated by both contextual factors and behavioral relevance. Our results, therefore, imply that the macaque visual system is an excellent model for the human visual cortex.
[Mh] Termos MeSH primário: Córtex Visual/fisiologia
Percepção Visual/fisiologia
[Mh] Termos MeSH secundário: Potenciais de Ação
Adulto
Animais
Atenção/fisiologia
Feminino
Humanos
Macaca
Imagem por Ressonância Magnética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1608
[Cu] Atualização por classe:160406
[Lr] Data última revisão:
160406
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160326
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pbio.1002420


  5 / 15934 MEDLINE  
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[PMID]:27010321
[Au] Autor:Nishimura T; Mori F; Hanida S; Kumahata K; Ishikawa S; Samarat K; Miyabe-Nishiwaki T; Hayashi M; Tomonaga M; Suzuki J; Matsuzawa T; Matsuzawa T
[Ad] Endereço:Primate Research Institute, Kyoto University, Inuyama, Aichi, Japan.
[Ti] Título:Impaired Air Conditioning within the Nasal Cavity in Flat-Faced Homo.
[So] Source:PLoS Comput Biol;12(3):e1004807, 2016 Mar.
[Is] ISSN:1553-7358
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We are flat-faced hominins with an external nose that protrudes from the face. This feature was derived in the genus Homo, along with facial flattening and reorientation to form a high nasal cavity. The nasal passage conditions the inhaled air in terms of temperature and humidity to match the conditions required in the lung, and its anatomical variation is believed to be evolutionarily sensitive to the ambient atmospheric conditions of a given habitat. In this study, we used computational fluid dynamics (CFD) with three-dimensional topology models of the nasal passage under the same simulation conditions, to investigate air-conditioning performance in humans, chimpanzees, and macaques. The CFD simulation showed a horizontal straight flow of inhaled air in chimpanzees and macaques, contrasting with the upward and curved flow in humans. The inhaled air is conditioned poorly in humans compared with nonhuman primates. Virtual modifications to the human external nose topology, in which the nasal vestibule and valve are modified to resemble those of chimpanzees, change the airflow to be horizontal, but have little influence on the air-conditioning performance in humans. These findings suggest that morphological variation of the nasal passage topology was only weakly sensitive to the ambient atmosphere conditions; rather, the high nasal cavity in humans was formed simply by evolutionary facial reorganization in the divergence of Homo from the other hominin lineages, impairing the air-conditioning performance. Even though the inhaled air is not adjusted well within the nasal cavity in humans, it can be fully conditioned subsequently in the pharyngeal cavity, which is lengthened in the flat-faced Homo. Thus, the air-conditioning faculty in the nasal passages was probably impaired in early Homo members, although they have survived successfully under the fluctuating climate of the Plio-Pleistocene, and then they moved "Out of Africa" to explore the more severe climates of Eurasia.
[Mh] Termos MeSH primário: Ar
Inalação/fisiologia
Cavidade Nasal/anatomia & histologia
Cavidade Nasal/fisiologia
Reologia/métodos
[Mh] Termos MeSH secundário: Ar Condicionado/métodos
Animais
Hominidae
Humanos
Umidade
Macaca
Pan troglodytes
Especificidade da Espécie
Temperatura Ambiente
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1607
[Cu] Atualização por classe:160326
[Lr] Data última revisão:
160326
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160325
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pcbi.1004807


  6 / 15934 MEDLINE  
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[PMID]:26998834
[Au] Autor:Hessell AJ; Jaworski JP; Epson E; Matsuda K; Pandey S; Kahl C; Reed J; Sutton WF; Hammond KB; Cheever TA; Barnette PT; Legasse AW; Planer S; Stanton JJ; Pegu A; Chen X; Wang K; Siess D; Burke D; Park BS; Axthelm MK; Lewis A; Hirsch VM; Graham BS; Mascola JR; Sacha JB; Haigwood NL
[Ad] Endereço:Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon, USA.
[Ti] Título:Early short-term treatment with neutralizing human monoclonal antibodies halts SHIV infection in infant macaques.
[So] Source:Nat Med;22(4):362-8, 2016 Apr.
[Is] ISSN:1546-170X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Prevention of mother-to-child transmission (MTCT) of HIV remains a major objective where antenatal care is not readily accessible. We tested HIV-1-specific human neutralizing monoclonal antibodies (NmAbs) as a post-exposure therapy in an infant macaque model for intrapartum MTCT. One-month-old rhesus macaques were inoculated orally with the simian-human immunodeficiency virus SHIVSF162P3. On days 1, 4, 7 and 10 after virus exposure, we injected animals subcutaneously with NmAbs and quantified systemic distribution of NmAbs in multiple tissues within 24 h after antibody administration. Replicating virus was found in multiple tissues by day 1 in animals that were not treated. All NmAb-treated macaques were free of virus in blood and tissues at 6 months after exposure. We detected no anti-SHIV T cell responses in blood or tissues at necropsy, and no virus emerged after CD8(+) T cell depletion. These results suggest that early passive immunotherapy can eliminate early viral foci and thereby prevent the establishment of viral reservoirs.
[Mh] Termos MeSH primário: Anticorpos Monoclonais/administração & dosagem
Anticorpos Neutralizantes/administração & dosagem
Síndrome de Imunodeficiência Adquirida dos Símios/quimioterapia
Vírus da Imunodeficiência Símia/efeitos de drogas
[Mh] Termos MeSH secundário: Animais
Anticorpos Monoclonais/imunologia
Anticorpos Neutralizantes/imunologia
Modelos Animais de Doenças
Infecções por HIV/quimioterapia
Infecções por HIV/transmissão
Infecções por HIV/virologia
HIV-1/imunologia
HIV-1/patogenicidade
Humanos
Macaca/virologia
Relações Mãe-Filho
Síndrome de Imunodeficiência Adquirida dos Símios/imunologia
Síndrome de Imunodeficiência Adquirida dos Símios/transmissão
Síndrome de Imunodeficiência Adquirida dos Símios/virologia
Vírus da Imunodeficiência Símia/imunologia
Vírus da Imunodeficiência Símia/patogenicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, N.I.H., INTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antibodies, Monoclonal); 0 (Antibodies, Neutralizing)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:161019
[Lr] Data última revisão:
161019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160407
[St] Status:MEDLINE
[do] DOI:10.1038/nm.4063


  7 / 15934 MEDLINE  
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[PMID]:26963915
[Au] Autor:Oosugi N; Yanagawa T; Nagasaka Y; Fujii N
[Ad] Endereço:Laboratory for Adaptive Intelligence, BSI, RIKEN, Wako, Saitama, Japan.
[Ti] Título:Social Suppressive Behavior Is Organized by the Spatiotemporal Integration of Multiple Cortical Regions in the Japanese Macaque.
[So] Source:PLoS One;11(3):e0150934, 2016.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Under social conflict, monkeys develop hierarchical positions through social interactions. Once the hierarchy is established, the dominant monkey dominates the space around itself and the submissive monkey tries not to violate this space. Previous studies have shown the contributions of the frontal and parietal cortices in social suppression, but the contributions of other cortical areas to suppressive functions remain elusive. We recorded neural activity in large cortical areas using electrocorticographic (ECoG) arrays while monkeys performed a social food-grab task in which a target monkey was paired with either a dominant or a submissive monkey. If the paired monkey was dominant, the target monkey avoided taking food in the shared conflict space, but not in other areas. By contrast, when the paired monkey was submissive, the target monkey took the food freely without hesitation. We applied decoding analysis to the ECoG data to see when and which cortical areas contribute to social behavioral suppression. Neural information discriminating the social condition was more evident when the conflict space was set in the area contralateral to the recording hemisphere. We found that the information increased as the social pressure increased during the task. Before food presentation, when the pressure was relatively low, the parietal and somatosensory-motor cortices showed sustained discrimination of the social condition. After food presentation, when the monkey faced greater pressure to make a decision as to whether it should take the food, the prefrontal and visual cortices started to develop buildup responses. The social representation was found in a sustained form in the parietal and somatosensory-motor regions, followed by additional buildup form in the visual and prefrontal cortices. The representation was less influenced by reward expectation. These findings suggest that social adaptation is achieved by a higher-order self-regulation process (incorporating motor preparation/execution processes) in accordance with the embodied social contexts.
[Mh] Termos MeSH primário: Comportamento Animal/fisiologia
Dominação-Subordinação
Eletrocorticografia
Macaca/fisiologia
Córtex Visual/fisiologia
[Mh] Termos MeSH secundário: Animais
Feminino
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1608
[Cu] Atualização por classe:160324
[Lr] Data última revisão:
160324
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160311
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0150934


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[PMID]:26961640
[Au] Autor:Reardon S
[Ti] Título:Welcome to the CRISPR zoo.
[So] Source:Nature;531(7593):160-3, 2016 Mar 10.
[Is] ISSN:1476-4687
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Sistemas CRISPR-Cas/genética
Engenharia Genética/métodos
[Mh] Termos MeSH secundário: Aclimatação/genética
Aclimatação/fisiologia
Febre Suína Africana/imunologia
Febre Suína Africana/virologia
Abate de Animais/métodos
Animais
Animais Selvagens/genética
Abelhas/genética
Abelhas/parasitologia
Abelhas/fisiologia
Cruzamento
Carpas/anatomia & histologia
Carpas/genética
Bovinos/genética
Bovinos/imunologia
Bovinos/fisiologia
Embrião de Galinha/imunologia
Galinhas/genética
Conservação de Recursos Naturais/métodos
Culicidae/genética
Culicidae/parasitologia
Modelos Animais de Doenças
Vetores de Doenças
Hipersensibilidade a Ovo/prevenção & controle
Elefantes/genética
Elefantes/fisiologia
Extinção Biológica
Feminino
Alimentos Geneticamente Modificados
Engenharia Genética/tendências
Humanos
Infertilidade Feminina/genética
Doença de Lyme/prevenção & controle
Doença de Lyme/transmissão
Macaca/genética
Malária/prevenção & controle
Malária/transmissão
Mamutes/genética
Mamutes/fisiologia
Animais de Estimação/anatomia & histologia
Animais de Estimação/genética
Síndrome de Rett/genética
Síndrome de Rett/fisiopatologia
Síndrome de Rett/psicologia
Salmão/genética
Salmão/crescimento & desenvolvimento
Esquistossomose/prevenção & controle
Esquistossomose/transmissão
Suínos
Porco Miniatura/anatomia & histologia
[Pt] Tipo de publicação:NEWS
[Em] Mês de entrada:1604
[Cu] Atualização por classe:160310
[Lr] Data última revisão:
160310
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160310
[St] Status:MEDLINE
[do] DOI:10.1038/531160a


  9 / 15934 MEDLINE  
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[PMID]:26958834
[Au] Autor:Daniels JT
[Ad] Endereço:University College London Institute of Ophthalmology, London EC1V 9EL, UK.
[Ti] Título:Biomedicine: Visionary stem-cell therapies.
[So] Source:Nature;531(7594):309-10, 2016 Mar 17.
[Is] ISSN:1476-4687
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Catarata/terapia
Córnea/citologia
Córnea/crescimento & desenvolvimento
Regeneração/fisiologia
Células-Tronco/citologia
Visão Ocular/fisiologia
[Mh] Termos MeSH secundário: Animais
Catarata/congênito
Catarata/patologia
Catarata/fisiopatologia
Extração de Catarata
Linhagem da Célula
Criança
Córnea/fisiologia
Transplante de Córnea
Ectoderma/citologia
Proteínas do Olho/metabolismo
Proteínas de Homeodomínio/metabolismo
Humanos
Células-Tronco Pluripotentes Induzidas/citologia
Macaca
Fator de Transcrição PAX6
Fatores de Transcrição Box Pareados/metabolismo
Complexo Repressor Polycomb 1/metabolismo
Proteínas Proto-Oncogênicas/metabolismo
Coelhos
Recuperação de Função Fisiológica
Proteínas Repressoras/metabolismo
Epitélio Pigmentado da Retina/citologia
Células-Tronco/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bmi1 protein, mouse); 0 (Eye Proteins); 0 (Homeodomain Proteins); 0 (PAX6 Transcription Factor); 0 (PAX6 protein, human); 0 (Paired Box Transcription Factors); 0 (Pax6 protein, mouse); 0 (Proto-Oncogene Proteins); 0 (Repressor Proteins); EC 2.3.2.27 (Polycomb Repressive Complex 1)
[Em] Mês de entrada:1604
[Cu] Atualização por classe:161126
[Lr] Data última revisão:
161126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160317
[St] Status:MEDLINE
[do] DOI:10.1038/nature17305


  10 / 15934 MEDLINE  
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Registro de Ensaios Clínicos
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[PMID]:26958831
[Au] Autor:Lin H; Ouyang H; Zhu J; Huang S; Liu Z; Chen S; Cao G; Li G; Signer RA; Xu Y; Chung C; Zhang Y; Lin D; Patel S; Wu F; Cai H; Hou J; Wen C; Jafari M; Liu X; Luo L; Zhu J; Qiu A; Hou R; Chen B; Chen J; Granet D; Heichel C; Shang F; Li X; Krawczyk M; Skowronska-Krawczyk D; Wang Y; Shi W; Chen D; Zhong Z; Zhong S; Zhang L; Chen S; Morrison SJ; Maas RL; Zhang K; Liu Y
[Ad] Endereço:State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China.
[Ti] Título:Lens regeneration using endogenous stem cells with gain of visual function.
[So] Source:Nature;531(7594):323-8, 2016 Mar 17.
[Is] ISSN:1476-4687
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The repair and regeneration of tissues using endogenous stem cells represents an ultimate goal in regenerative medicine. To our knowledge, human lens regeneration has not yet been demonstrated. Currently, the only treatment for cataracts, the leading cause of blindness worldwide, is to extract the cataractous lens and implant an artificial intraocular lens. However, this procedure poses notable risks of complications. Here we isolate lens epithelial stem/progenitor cells (LECs) in mammals and show that Pax6 and Bmi1 are required for LEC renewal. We design a surgical method of cataract removal that preserves endogenous LECs and achieves functional lens regeneration in rabbits and macaques, as well as in human infants with cataracts. Our method differs conceptually from current practice, as it preserves endogenous LECs and their natural environment maximally, and regenerates lenses with visual function. Our approach demonstrates a novel treatment strategy for cataracts and provides a new paradigm for tissue regeneration using endogenous stem cells.
[Mh] Termos MeSH primário: Catarata/terapia
Cristalino/citologia
Cristalino/fisiologia
Recuperação de Função Fisiológica
Regeneração/fisiologia
Células-Tronco/citologia
Visão Ocular/fisiologia
[Mh] Termos MeSH secundário: Animais
Catarata/congênito
Catarata/patologia
Catarata/fisiopatologia
Extração de Catarata
Células Epiteliais/citologia
Células Epiteliais/metabolismo
Proteínas do Olho/metabolismo
Proteínas de Homeodomínio/metabolismo
Homeostase
Humanos
Macaca
Fator de Transcrição PAX6
Fatores de Transcrição Box Pareados/metabolismo
Complexo Repressor Polycomb 1/metabolismo
Proteínas Proto-Oncogênicas/metabolismo
Proteínas Repressoras/metabolismo
Células-Tronco/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Bmi1 protein, mouse); 0 (Eye Proteins); 0 (Homeodomain Proteins); 0 (PAX6 Transcription Factor); 0 (PAX6 protein, human); 0 (Paired Box Transcription Factors); 0 (Pax6 protein, mouse); 0 (Proto-Oncogene Proteins); 0 (Repressor Proteins); EC 2.3.2.27 (Polycomb Repressive Complex 1)
[Em] Mês de entrada:1604
[Cu] Atualização por classe:161206
[Lr] Data última revisão:
161206
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160317
[Cl] Clinical Trial:ClinicalTrial
[St] Status:MEDLINE
[do] DOI:10.1038/nature17181



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