Base de dados : MEDLINE
Pesquisa : B01.050.150.900.649.801.400.112.199.120.510 [Categoria DeCS]
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  1 / 15996 MEDLINE  
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[PMID]:28299780
[Au] Autor:Van Minh N; Hamada Y
[Ad] Endereço:Faculty of Forestry, University of Agriculture and Forestry, Hue University, Hue, Thua Thien Hue, Vietnam.
[Ti] Título:Age-related changes of sulcal imprints on the endocranium in the Japanese macaque (Macaca fuscata).
[So] Source:Am J Phys Anthropol;163(2):285-294, 2017 Jun.
[Is] ISSN:1096-8644
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: The degree of expression of sulcal patterns on endocasts of nonhuman primates has been shown to depend primarily on species (brain size) and age of the individual. It has been suggested that brain details on endocasts are reproduced better in juvenile than adult primates. Here, we investigated age-related changes in the imprint of the major sulci on the endocranium of Japanese macaques (Macaca fuscata) from the juvenile period to adulthood. MATERIALS AND METHODS: Using CT scans of 25 (12 males, 13 females) cranial specimens from macaques, we generated virtual endocasts to assess imprints of the seven main sulci on the endocranial surface. Expression of each sulcal imprint was evaluated by imprint score method. RESULTS: The degree of expression of sulcal imprints differed between sulci. Arcuate, superior temporal, and principal sulci were well defined, whereas lunate and intraparietal sulci were poorly represented. Sulcal imprints showed significant age-related changes in Japanese macaques from juvenile to elderly. Sulcal imprints showed a slight decrease in degree of expression from the juvenile period (2-4 years) to adolescence (4-6 years), and then remained unchanged until mid-adulthood (15-16 years). The degree of expression of the sulcal imprints significantly decreased from mid-adulthood to old age (>20 years). CONCLUSIONS: The degree of expression of the sulcal imprints (relief forms) in inner table bone surface (endocranium) reveals significant age-related decreases in adults. The great decrease starts at around 20 years of age. The endocranial volume showed a significant age-related increase, and thus, it is suggested that the endocranial surface in macaques may be resorbed with advancing age.
[Mh] Termos MeSH primário: Envelhecimento/fisiologia
Encéfalo/anatomia & histologia
Macaca/anatomia & histologia
Crânio/anatomia & histologia
[Mh] Termos MeSH secundário: Animais
Antropologia Física
Feminino
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170626
[Lr] Data última revisão:
170626
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170316
[St] Status:MEDLINE
[do] DOI:10.1002/ajpa.23205


  2 / 15996 MEDLINE  
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[PMID]:28118355
[Au] Autor:Heitmann S; Rule M; Truccolo W; Ermentrout B
[Ad] Endereço:Department of Mathematics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
[Ti] Título:Optogenetic Stimulation Shifts the Excitability of Cerebral Cortex from Type I to Type II: Oscillation Onset and Wave Propagation.
[So] Source:PLoS Comput Biol;13(1):e1005349, 2017 Jan.
[Is] ISSN:1553-7358
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Constant optogenetic stimulation targeting both pyramidal cells and inhibitory interneurons has recently been shown to elicit propagating waves of gamma-band (40-80 Hz) oscillations in the local field potential of non-human primate motor cortex. The oscillations emerge with non-zero frequency and small amplitude-the hallmark of a type II excitable medium-yet they also propagate far beyond the stimulation site in the manner of a type I excitable medium. How can neural tissue exhibit both type I and type II excitability? We investigated the apparent contradiction by modeling the cortex as a Wilson-Cowan neural field in which optogenetic stimulation was represented by an external current source. In the absence of any external current, the model operated as a type I excitable medium that supported propagating waves of gamma oscillations similar to those observed in vivo. Applying an external current to the population of inhibitory neurons transformed the model into a type II excitable medium. The findings suggest that cortical tissue normally operates as a type I excitable medium but it is locally transformed into a type II medium by optogenetic stimulation which predominantly targets inhibitory neurons. The proposed mechanism accounts for the graded emergence of gamma oscillations at the stimulation site while retaining propagating waves of gamma oscillations in the non-stimulated tissue. It also predicts that gamma waves can be emitted on every second cycle of a 100 Hz oscillation. That prediction was subsequently confirmed by re-analysis of the neurophysiological data. The model thus offers a theoretical account of how optogenetic stimulation alters the excitability of cortical neural fields.
[Mh] Termos MeSH primário: Córtex Cerebral/fisiologia
Interneurônios/fisiologia
Optogenética/métodos
[Mh] Termos MeSH secundário: Animais
Biologia Computacional
Ritmo Gama/fisiologia
Macaca
Modelos Neurológicos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170626
[Lr] Data última revisão:
170626
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170124
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pcbi.1005349


  3 / 15996 MEDLINE  
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[PMID]:28328549
[Au] Autor:Zhou RH; Guo L; Liu JB; Liu H; Hou W; Ma TC; Wang X; Wu JG; Ye L; Ho WZ; Li JL
[Ad] Endereço:*School of Basic Medical Sciences/State Key Laboratory of Virology, Wuhan University, Wuhan, China; †Department of Pathology and Laboratory Medicine, Temple University Lewis Katz School of Medicine, Philadelphia, PA; and ‡School of Public Health, Guangxi Medical University, Nanning, China.
[Ti] Título:Epigallocatechin Gallate Inhibits Macaque SEVI-Mediated Enhancement of SIV or SHIV Infection.
[So] Source:J Acquir Immune Defic Syndr;75(2):232-240, 2017 Jun 01.
[Is] ISSN:1944-7884
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Human semen contains a factor that can enhance HIV infection up to 10-fold in cultures. This factor is termed semen-derived enhancer of virus infection (SEVI) and is composed of proteolytic fragments (PAP248-286) from prostatic acid phosphatase in semen. In this study, we examined whether macaque SEVI can facilitate simian immunodeficiency virus (SIV) or chimeric simian/human immunodeficiency virus (SHIV) infection. We also studied the effect of epigallocatechin gallate (EGCG) on macaque SEVI-mediated SIV or SHIV enhancement. METHODS: SIV or SHIV was mixed with different concentrations of macaque SEVI in the presence or absence of EGCG. The mixture was added to cultures of TZM-bl cells or macaque PBMCs. The effect of EGCG on macaque SEVI was measured by Congo-red staining assay and thioflavin T (ThT) fluorescence assay and was visualized by a transmission electron microscope. RESULTS: We identified that there is one amino acid difference at the site of 277 between human PAP248-286 and macaque PAP248-286. Macaque SEVI significantly enhanced SIV or SHIV infection of TZM-bl cells and macaque PBMCs. EGCG could block macaque SEVI-mediated enhancement of SIV or SHIV infection. Mechanistically, EGCG could degrade the formation of macaque SEVI amyloid fibrils that facilitates HIV attachment to the target cells. CONCLUSIONS: The finding that macaque SEVI could enhance SIV or SHIV infection indicates the possibility to use the macaque SEVI in vivo studies with the macaque models. In addition, future studies are necessary to examine whether EGCG can be used as an effective microbicide for preventing SIV or SHIV mucosal transmission.
[Mh] Termos MeSH primário: Catequina/análogos & derivados
Inibidores de Proteases/farmacologia
Síndrome de Imunodeficiência Adquirida dos Símios/prevenção & controle
Síndrome de Imunodeficiência Adquirida dos Símios/transmissão
Vírus da Imunodeficiência Símia/efeitos de drogas
Vírus da Imunodeficiência Símia/patogenicidade
[Mh] Termos MeSH secundário: Animais
Catequina/farmacologia
Macaca
Masculino
Membrana Mucosa/efeitos de drogas
Membrana Mucosa/virologia
Ligação Proteica
Sêmen/efeitos de drogas
Sêmen/virologia
Síndrome de Imunodeficiência Adquirida dos Símios/quimioterapia
Síndrome de Imunodeficiência Adquirida dos Símios/virologia
Ligação Viral/efeitos de drogas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Protease Inhibitors); 8R1V1STN48 (Catechin); BQM438CTEL (epigallocatechin gallate)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170623
[Lr] Data última revisão:
170623
[Sb] Subgrupo de revista:IM; X
[Da] Data de entrada para processamento:170322
[St] Status:MEDLINE
[do] DOI:10.1097/QAI.0000000000001361


  4 / 15996 MEDLINE  
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[PMID]:28148210
[Au] Autor:Asahara M; Nishioka Y
[Ad] Endereço:College of Liberal Arts and Sciences, Mie University, Kurima-Machiya-Cho, Tsu, Mie 514-8507, Japan.
[Ti] Título:Geographic Variation of Absolute and Relative Lower Molar Sizes in the Japanese Macaque (Macaca fuscata: Primates, Mammalia).
[So] Source:Zoolog Sci;34(1):35-41, 2017 Feb.
[Is] ISSN:0289-0003
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:We examined geographic variations of absolute and relative lower molar sizes (size proportions among M , M , and M ) in the Japanese macaque (Macaca fuscata) using skull specimens obtained from 13 locations. We compared the geographic patterns and climatic factors. The size of M significantly and negatively correlated to the annual and coldest month mean temperatures and precipitation for both males and females. The M /M and M /M scores significantly and positively correlated to the annual and coldest month mean temperatures. The geographic pattern in the size of M was consistent with Bergmann's rule; however, the sizes of M and M did not correlate with temperature, and were not consistent with the rule. The geographic pattern in relative molar sizes (M /M and M /M scores) indicated that populations living in colder climates possess a larger M in relation to M and M . Therefore, the correlations of M , M /M , and M /M scores to temperature involve an increase in the size of M in a colder climate. In macaques, the functions of the different molars (M , M , and M ) do not differ (they all exhibit grinding function, unlike differentiation between carnassial and other molars in Carnivora), whereas the timing of molar eruption does. In other words, at young ages (1.5-3.5 years), M erupts and is in occlusion, whereas M and M do not erupt and are not used for mastication. Therefore, the geographic pattern in the relative molar sizes may be attributed to increasing survivability in harsh winter climates by increasing occlusal surface in younger animals.
[Mh] Termos MeSH primário: Distribuição Animal/fisiologia
Macaca/anatomia & histologia
Macaca/fisiologia
Dente Molar/anatomia & histologia
[Mh] Termos MeSH secundário: Animais
Feminino
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170622
[Lr] Data última revisão:
170622
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170202
[St] Status:MEDLINE
[do] DOI:10.2108/zs160104


  5 / 15996 MEDLINE  
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[PMID]:27981746
[Au] Autor:Xue J; Fu C; Cong Z; Peng L; Peng Z; Chen T; Wang W; Jiang H; Wei Q; Qin C
[Ad] Endereço:Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Comparative Medicine Center, Peking Union Medical College (PUMC), Key Laboratory of Human Disease Comparative Medicine, Ministry of Health, Beijing Key Laboratory for Animal Models of Emerging and Remerging Infect
[Ti] Título:Galectin-3 promotes caspase-independent cell death of HIV-1-infected macrophages.
[So] Source:FEBS J;284(1):97-113, 2017 Jan.
[Is] ISSN:1742-4658
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:HIV-1-infected macrophages are a key contributor to the formation of a viral reservoir and new treatment strategies focus on eliminating this pool of virus. Galectin-3 is a potent apoptosis-inducing protein that regulates diverse cellular activities. In the present study, we investigated whether galectin-3 could induce cell death in HIV-1-infected macrophages using HIV-1-infected THP1 monocytes (THP1-MNs) and THP1-derived macrophages (THP1-MΦs) as in vitro cellular models. We found that THP1-MΦs were more resistant than the THP1-MNs to HIV-1 infection-induced death, and that HIV-1 infection of the THP1-MΦs increased expression of the anti-apoptotic proteins Mcl-1, Bcl-2 and Bcl-xL. Additionally, galectin-3 but not FasL, tumor necrosis factor (TNF)-related apoptosis-inducing ligand or TNF-α, could induce cell death in HIV-1-infected THP1-MΦs. A similar result was shown for primary human monocyte-derived macrophages. Galectin-3-induced cell death was also significantly increased in macrophages obtained from SIVmac251-infected macaques compared to that of macrophages from healthy macaques. Furthermore, galectin-3-induced cell death in HIV-1-infected THP1-MΦs was caspase independent. Interestingly, endonuclease G (Endo G) was increased in the nucleus and decreased in the cytoplasm of galectin-3-treated cells; thus, galectin-3-induced cell death in HIV-1-infected THP1-MΦs is most likely related to the translocation of Endo G from the cytoplasm to the nucleus. These findings suggest that galectin-3 may potentially aid in the eradication of HIV-1/SIV-infected macrophages.
[Mh] Termos MeSH primário: Endodesoxirribonucleases/genética
Galectina 3/farmacologia
HIV-1/efeitos de drogas
Macrófagos/efeitos de drogas
Monócitos/efeitos de drogas
[Mh] Termos MeSH secundário: Transporte Ativo do Núcleo Celular/efeitos de drogas
Animais
Morte Celular/efeitos de drogas
Linhagem Celular
Núcleo Celular/efeitos de drogas
Núcleo Celular/metabolismo
Citoplasma/efeitos de drogas
Citoplasma/metabolismo
Endodesoxirribonucleases/metabolismo
Proteína Ligante Fas/genética
Proteína Ligante Fas/metabolismo
Galectina 3/genética
Galectina 3/metabolismo
Regulação da Expressão Gênica
HIV-1/crescimento & desenvolvimento
Humanos
Macaca
Macrófagos/patologia
Macrófagos/virologia
Monócitos/patologia
Monócitos/virologia
Proteína de Sequência 1 de Leucemia de Células Mieloides/genética
Proteína de Sequência 1 de Leucemia de Células Mieloides/metabolismo
Transporte Proteico/efeitos de drogas
Proteínas Proto-Oncogênicas c-bcl-2/genética
Proteínas Proto-Oncogênicas c-bcl-2/metabolismo
Transdução de Sinal
Vírus da Imunodeficiência Símia/efeitos de drogas
Vírus da Imunodeficiência Símia/crescimento & desenvolvimento
Membro 13 da Superfamília de Ligantes de Fatores de Necrose Tumoral/farmacologia
Fator de Necrose Tumoral alfa/farmacologia
Proteína bcl-X/genética
Proteína bcl-X/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (BCL2 protein, human); 0 (BCL2L1 protein, human); 0 (FASLG protein, human); 0 (Fas Ligand Protein); 0 (Galectin 3); 0 (MCL1 protein, human); 0 (Myeloid Cell Leukemia Sequence 1 Protein); 0 (Proto-Oncogene Proteins c-bcl-2); 0 (Tumor Necrosis Factor Ligand Superfamily Member 13); 0 (Tumor Necrosis Factor-alpha); 0 (bcl-X Protein); EC 3.1.- (Endodeoxyribonucleases); EC 3.1.21.- (endonuclease G)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170622
[Lr] Data última revisão:
170622
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161216
[St] Status:MEDLINE
[do] DOI:10.1111/febs.13955


  6 / 15996 MEDLINE  
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[PMID]:28146554
[Au] Autor:Schuecker J; Schmidt M; van Albada SJ; Diesmann M; Helias M
[Ad] Endereço:Institute of Neuroscience and Medicine (INM-6) and Institute for Advanced Simulation (IAS-6) and JARA BRAIN Institute I, Jülich Research Centre, Jülich, Germany.
[Ti] Título:Fundamental Activity Constraints Lead to Specific Interpretations of the Connectome.
[So] Source:PLoS Comput Biol;13(2):e1005179, 2017 Feb.
[Is] ISSN:1553-7358
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The continuous integration of experimental data into coherent models of the brain is an increasing challenge of modern neuroscience. Such models provide a bridge between structure and activity, and identify the mechanisms giving rise to experimental observations. Nevertheless, structurally realistic network models of spiking neurons are necessarily underconstrained even if experimental data on brain connectivity are incorporated to the best of our knowledge. Guided by physiological observations, any model must therefore explore the parameter ranges within the uncertainty of the data. Based on simulation results alone, however, the mechanisms underlying stable and physiologically realistic activity often remain obscure. We here employ a mean-field reduction of the dynamics, which allows us to include activity constraints into the process of model construction. We shape the phase space of a multi-scale network model of the vision-related areas of macaque cortex by systematically refining its connectivity. Fundamental constraints on the activity, i.e., prohibiting quiescence and requiring global stability, prove sufficient to obtain realistic layer- and area-specific activity. Only small adaptations of the structure are required, showing that the network operates close to an instability. The procedure identifies components of the network critical to its collective dynamics and creates hypotheses for structural data and future experiments. The method can be applied to networks involving any neuron model with a known gain function.
[Mh] Termos MeSH primário: Conectoma
Potenciais Evocados Visuais/fisiologia
Modelos Neurológicos
Córtex Visual/anatomia & histologia
Córtex Visual/fisiologia
Percepção Visual/fisiologia
[Mh] Termos MeSH secundário: Animais
Simulação por Computador
Humanos
Macaca
Modelos Anatômicos
Modelos Estatísticos
Rede Nervosa/fisiologia
Transmissão Sináptica/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170619
[Lr] Data última revisão:
170619
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170201
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pcbi.1005179


  7 / 15996 MEDLINE  
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[PMID]:28141820
[Au] Autor:Hinne M; Meijers A; Bakker R; Tiesinga PH; Mørup M; van Gerven MA
[Ad] Endereço:Radboud University, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, the Netherlands.
[Ti] Título:The missing link: Predicting connectomes from noisy and partially observed tract tracing data.
[So] Source:PLoS Comput Biol;13(1):e1005374, 2017 01.
[Is] ISSN:1553-7358
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Our understanding of the wiring map of the brain, known as the connectome, has increased greatly in the last decade, mostly due to technological advancements in neuroimaging techniques and improvements in computational tools to interpret the vast amount of available data. Despite this, with the exception of the C. elegans roundworm, no definitive connectome has been established for any species. In order to obtain this, tracer studies are particularly appealing, as these have proven highly reliable. The downside of tract tracing is that it is costly to perform, and can only be applied ex vivo. In this paper, we suggest that instead of probing all possible connections, hitherto unknown connections may be predicted from the data that is already available. Our approach uses a 'latent space model' that embeds the connectivity in an abstract physical space. Regions that are close in the latent space have a high chance of being connected, while regions far apart are most likely disconnected in the connectome. After learning the latent embedding from the connections that we did observe, the latent space allows us to predict connections that have not been probed previously. We apply the methodology to two connectivity data sets of the macaque, where we demonstrate that the latent space model is successful in predicting unobserved connectivity, outperforming two baselines and an alternative model in nearly all cases. Furthermore, we show how the latent spatial embedding may be used to integrate multimodal observations (i.e. anterograde and retrograde tracers) for the mouse neocortex. Finally, our probabilistic approach enables us to make explicit which connections are easy to predict and which prove difficult, allowing for informed follow-up studies.
[Mh] Termos MeSH primário: Encéfalo/anatomia & histologia
Córtex Cerebral/anatomia & histologia
Conectoma/métodos
Imagem de Tensor de Difusão/métodos
Modelos Neurológicos
Substância Branca/anatomia & histologia
[Mh] Termos MeSH secundário: Animais
Artefatos
Simulação por Computador
Macaca
Modelos Anatômicos
Modelos Estatísticos
Tamanho da Amostra
Razão Sinal-Ruído
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170616
[Lr] Data última revisão:
170616
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170131
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pcbi.1005374


  8 / 15996 MEDLINE  
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[PMID]:28128250
[Au] Autor:Landhuis E
[Ti] Título:Neuroscience: Big brain, big data.
[So] Source:Nature;541(7638):559-561, 2017 01 25.
[Is] ISSN:1476-4687
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Encéfalo/anatomia & histologia
Encéfalo/citologia
Conjuntos de Dados como Assunto
Vias Neurais
Neurociências/métodos
[Mh] Termos MeSH secundário: Animais
Mapeamento Encefálico
Drosophila melanogaster/citologia
Eletrofisiologia
Humanos
Macaca
Camundongos
Neurociências/organização & administração
Software
Estatística como Assunto
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170616
[Lr] Data última revisão:
170616
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170127
[St] Status:MEDLINE
[do] DOI:10.1038/541559a


  9 / 15996 MEDLINE  
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[PMID]:28418297
[Au] Autor:Klegarth AR; Ezeonwu CA; Rompis A; Lee BPY; Aggimarangsee N; Chalise M; Cortes J; Feeroz M; Molini BJ; Godornes BC; Marks M; Schillaci M; Engel G; Knauf S; Lukehart SA; Jones-Engel L
[Ti] Título:Survey of Treponemal Infections in Free-Ranging and Captive Macaques, 1999-2012.
[So] Source:Emerg Infect Dis;23(5):816-819, 2017 May.
[Is] ISSN:1080-6059
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Survey results showed treponemal infection among pet macaques in Southeast Asia, a region with a high prevalence of human yaws. This finding, along with studies showing treponemal infection in nonhuman primates in Africa, should encourage a One Health approach to yaws eradication and surveillance activities, possibly including monitoring of nonhuman primates in yaws-endemic regions.
[Mh] Termos MeSH primário: Doenças dos Macacos/epidemiologia
Doenças dos Macacos/microbiologia
Infecções por Treponema/veterinária
[Mh] Termos MeSH secundário: Animais
Inquéritos Epidemiológicos
História do Século XX
História do Século XXI
Indonésia/epidemiologia
Macaca
Doenças dos Macacos/história
[Pt] Tipo de publicação:HISTORICAL ARTICLE; JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170615
[Lr] Data última revisão:
170615
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170418
[St] Status:MEDLINE
[do] DOI:10.3201/eid2305.161838


  10 / 15996 MEDLINE  
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[PMID]:28129540
[Au] Autor:Sinha R; Hoon M; Baudin J; Okawa H; Wong RO; Rieke F
[Ad] Endereço:Department of Physiology and Biophysics, University of Washington, Seattle, Washington 98195, USA; Howard Hughes Medical Institute, University of Washington, Seattle, Washington 98195, USA. Electronic address: rsinha@uw.edu.
[Ti] Título:Cellular and Circuit Mechanisms Shaping the Perceptual Properties of the Primate Fovea.
[So] Source:Cell;168(3):413-426.e12, 2017 Jan 26.
[Is] ISSN:1097-4172
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The fovea is a specialized region of the retina that dominates the visual perception of primates by providing high chromatic and spatial acuity. While the foveal and peripheral retina share a similar core circuit architecture, they exhibit profound functional differences whose mechanisms are unknown. Using intracellular recordings and structure-function analyses, we examined the cellular and synaptic underpinnings of the primate fovea. Compared to peripheral vision, the fovea displays decreased sensitivity to rapid variations in light inputs; this difference is reflected in the responses of ganglion cells, the output cells of the retina. Surprisingly, and unlike in the periphery, synaptic inhibition minimally shaped the responses of foveal midget ganglion cells. This difference in inhibition cannot however, explain the differences in the temporal sensitivity of foveal and peripheral midget ganglion cells. Instead, foveal cone photoreceptors themselves exhibited slower light responses than peripheral cones, unexpectedly linking cone signals to perceptual sensitivity.
[Mh] Termos MeSH primário: Fóvea Central/fisiologia
Macaca/fisiologia
Células Fotorreceptoras Retinianas Cones/fisiologia
Percepção Visual
[Mh] Termos MeSH secundário: Animais
Cinética
Células Fotorreceptoras de Vertebrados/fisiologia
Células Ganglionares da Retina/fisiologia
Sinapses
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170614
[Lr] Data última revisão:
170614
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170127
[St] Status:MEDLINE



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