Base de dados : MEDLINE
Pesquisa : B01.050.150.900.649.801.400.112.199.120.510.570 [Categoria DeCS]
Referências encontradas : 723 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 73 ir para página                         

  1 / 723 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28880949
[Au] Autor:Coplan JD; Gupta NK; Karim A; Rozenboym A; Smith ELP; Kral JG; Rosenblum LA
[Ad] Endereço:Department of Psychiatry and Behavioral Sciences, Biological Science Unit, State University of New York (SUNY) Downstate Medical Center, Brooklyn, New York, United States of America.
[Ti] Título:Maternal hypothalamic-pituitary-adrenal axis response to foraging uncertainty: A model of individual vs. social allostasis and the "Superorganism Hypothesis".
[So] Source:PLoS One;12(9):e0184340, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Food insecurity is a major global contributor to developmental origins of adult disease. The allostatic load of maternal food uncertainty from variable foraging demand (VFD) activates corticotropin-releasing factor (CRF) without eliciting hypothalamic-pituitary-adrenal (HPA) activation measured on a group level. Individual homeostatic adaptations of the HPA axis may subserve second-order homeostasis, a process we provisionally term "social allostasis." We postulate that maternal food insecurity induces a "superorganism" state through coordination of individual HPA axis response. METHODS: Twenty-four socially-housed bonnet macaque maternal-infant dyads were exposed to 16 weeks of alternating two-week epochs of low or high foraging demand shown to compromise normative maternal-infant rearing. Cerebrospinal fluid (CSF) CRF concentrations and plasma cortisol were measured pre- and post-VFD. Dyadic distance was measured, and blinded observers performed pre-VFD social ranking assessments. RESULTS: Despite marked individual cortisol responses (mean change = 20%) there was an absence of maternal HPA axis group mean response to VFD (0%). Whereas individual CSF CRF concentrations change = 56%, group mean did increase 25% (p = 0.002). Our "dyadic vulnerability" index (low infant weight, low maternal weight, subordinate maternal social status and reduced dyadic distance) predicted maternal cortisol decreases (p < 0.0001) whereas relatively "advantaged" dyads exhibited maternal cortisol increases in response to VFD exposure. COMMENT: In response to a chronic stressor, relative dyadic vulnerability plays a significant role in determining the directionality and magnitude of individual maternal HPA axis responses in the service of maintaining a "superorganism" version of HPA axis homeostasis, provisionally termed "social allostasis."
[Mh] Termos MeSH primário: Comportamento Alimentar/fisiologia
Macaca radiata/fisiologia
Comportamento Materno/fisiologia
[Mh] Termos MeSH secundário: Alostase
Animais
Hormônio Liberador da Corticotropina/sangue
Hormônio Liberador da Corticotropina/líquido cefalorraquidiano
Feminino
Hidrocortisona/sangue
Hidrocortisona/líquido cefalorraquidiano
Sistema Hipotálamo-Hipofisário/metabolismo
Sistema Hipotálamo-Hipofisário/fisiologia
Sistema Hipófise-Suprarrenal/metabolismo
Sistema Hipófise-Suprarrenal/fisiologia
Incerteza
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
9015-71-8 (Corticotropin-Releasing Hormone); WI4X0X7BPJ (Hydrocortisone)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170907
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0184340


  2 / 723 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28268958
[Au] Autor:McNiel DB; Choi JS; Hessburg JP; Francis JT
[Ti] Título:Reward value is encoded in primary somatosensory cortex and can be decoded from neural activity during performance of a psychophysical task.
[So] Source:Conf Proc IEEE Eng Med Biol Soc;2016:3064-3067, 2016 Aug.
[Is] ISSN:1557-170X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Encoding of reward valence has been shown in various brain regions, including deep structures such as the substantia nigra as well as cortical structures such as the orbitofrontal cortex. While the correlation between these signals and reward valence have been shown in aggregated data comprised of many trials, little work has been done investigating the feasibility of decoding reward valence on a single trial basis. Towards this goal, one non-human primate (macaca radiata) was trained to grip and hold a target level of force in order to earn zero, one, two, or three juice rewards. The animal was informed of the impending result before reward delivery by means of a visual cue. Neural data was recorded from primary somatosensory cortex (S1) during these experiments and firing rate histograms were created following the appearance of the visual cue and used as input to a variety of classifiers. Reward valence was decoded with high levels of accuracy from S1 both in the post-cue and post-reward periods. Additionally, the proportion of units showing significant changes in their firing rates was influenced in a predictable way based on reward valence. The existence of a signal within S1 cortex that encodes reward valence could have utility for implementing reinforcement learning algorithms for brain machine interfaces. The ability to decode this reward signal in real time with limited data is paramount to the usability of such a signal in practical applications.
[Mh] Termos MeSH primário: Psicofísica
Recompensa
Córtex Somatossensorial/fisiologia
[Mh] Termos MeSH secundário: Animais
Macaca radiata
Neurônios/citologia
Córtex Pré-Frontal/citologia
Córtex Pré-Frontal/fisiologia
Reforço (Psicologia)
Córtex Somatossensorial/citologia
Substância Negra/citologia
Substância Negra/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170626
[Lr] Data última revisão:
170626
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170308
[St] Status:MEDLINE
[do] DOI:10.1109/EMBC.2016.7591376


  3 / 723 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28413827
[Au] Autor:Ratan Murty NA; Arun SP
[Ad] Endereço:Centre for Neuroscience, Indian Institute of Science, Bangalore, India.
[Ti] Título:A Balanced Comparison of Object Invariances in Monkey IT Neurons.
[So] Source:eNeuro;4(2), 2017 Mar-Apr.
[Is] ISSN:2373-2822
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Our ability to recognize objects across variations in size, position, or rotation is based on invariant object representations in higher visual cortex. However, we know little about how these invariances are related. Are some invariances harder than others? Do some invariances arise faster than others? These comparisons can be made only upon equating image changes across transformations. Here, we targeted invariant neural representations in the monkey inferotemporal (IT) cortex using object images with balanced changes in size, position, and rotation. Across the recorded population, IT neurons generalized across size and position both stronger and faster than to rotations in the image plane as well as in depth. We obtained a similar ordering of invariances in deep neural networks but not in low-level visual representations. Thus, invariant neural representations dynamically evolve in a temporal order reflective of their underlying computational complexity.
[Mh] Termos MeSH primário: Neurônios/fisiologia
Reconhecimento Visual de Modelos/fisiologia
Rotação
Percepção de Tamanho/fisiologia
Córtex Visual/citologia
[Mh] Termos MeSH secundário: Potenciais de Ação/fisiologia
Animais
Simulação por Computador
Fixação Ocular/fisiologia
Lateralidade Funcional
Macaca radiata
Masculino
Redes Neurais (Computação)
Dinâmica não Linear
Estimulação Luminosa
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170424
[Lr] Data última revisão:
170424
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170417
[St] Status:MEDLINE


  4 / 723 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27153397
[Au] Autor:Do C; Lang CF; Lin J; Darbary H; Krupska I; Gaba A; Petukhova L; Vonsattel JP; Gallagher MP; Goland RS; Clynes RA; Dwork A; Kral JG; Monk C; Christiano AM; Tycko B
[Ad] Endereço:Institute for Cancer Genetics, Columbia University, New York, NY 10032, USA. Electronic address: cd2695@columbia.edu.
[Ti] Título:Mechanisms and Disease Associations of Haplotype-Dependent Allele-Specific DNA Methylation.
[So] Source:Am J Hum Genet;98(5):934-55, 2016 May 05.
[Is] ISSN:1537-6605
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Haplotype-dependent allele-specific methylation (hap-ASM) can impact disease susceptibility, but maps of this phenomenon using stringent criteria in disease-relevant tissues remain sparse. Here we apply array-based and Methyl-Seq approaches to multiple human tissues and cell types, including brain, purified neurons and glia, T lymphocytes, and placenta, and identify 795 hap-ASM differentially methylated regions (DMRs) and 3,082 strong methylation quantitative trait loci (mQTLs), most not previously reported. More than half of these DMRs have cell type-restricted ASM, and among them are 188 hap-ASM DMRs and 933 mQTLs located near GWAS signals for immune and neurological disorders. Targeted bis-seq confirmed hap-ASM in 12/13 loci tested, including CCDC155, CD69, FRMD1, IRF1, KBTBD11, and S100A(∗)-ILF2, associated with immune phenotypes, MYT1L, PTPRN2, CMTM8 and CELF2, associated with neurological disorders, NGFR and HLA-DRB6, associated with both immunological and brain disorders, and ZFP57, a trans-acting regulator of genomic imprinting. Polymorphic CTCF and transcription factor (TF) binding sites were over-represented among hap-ASM DMRs and mQTLs, and analysis of the human data, supplemented by cross-species comparisons to macaques, indicated that CTCF and TF binding likelihood predicts the strength and direction of the allelic methylation asymmetry. These results show that hap-ASM is highly tissue specific; an important trans-acting regulator of genomic imprinting is regulated by this phenomenon; and variation in CTCF and TF binding sites is an underlying mechanism, and maps of hap-ASM and mQTLs reveal regulatory sequences underlying supra- and sub-threshold GWAS peaks in immunological and neurological disorders.
[Mh] Termos MeSH primário: Metilação de DNA
Impressão Genômica
Haplotipos/genética
Polimorfismo de Nucleotídeo Único/genética
Locos de Características Quantitativas
Transativadores/genética
[Mh] Termos MeSH secundário: Alelos
Animais
Encéfalo/metabolismo
Encéfalo/patologia
Feminino
Estudo de Associação Genômica Ampla
Humanos
Doenças do Sistema Imune/genética
Macaca mulatta
Macaca radiata
Doenças do Sistema Nervoso/genética
Placenta/metabolismo
Placenta/patologia
Gravidez
Especificidade da Espécie
Linfócitos T/metabolismo
Linfócitos T/patologia
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Trans-Activators)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170515
[Lr] Data última revisão:
170515
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160507
[St] Status:MEDLINE


  5 / 723 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:26946119
[Au] Autor:Chaudhari UK; Imran M; Manjramkar DD; Metkari SM; Sable NP; Gavhane DS; Katkam RR; Sachdeva G; Thakur MH; Kholkute SD
[Ad] Endereço:1 Department of Primate Biology, National Institute for Research in Reproductive Health (NIRRH), Indian Council of Medical Research (ICMR), Parel, Mumbai, India.
[Ti] Título:Use of ultrasound imaging for the diagnosis of abnormal uterine bleeding in the bonnet macaque ( Macaca radiata).
[So] Source:Lab Anim;51(1):65-74, 2017 Feb.
[Is] ISSN:1758-1117
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Ultrasound is a powerful, low-cost, non-invasive medical tool used by laboratory animal veterinarians for diagnostic imaging. Sonohysterography and transvaginal ultrasound are frequently used to assess uterine anomalies in women presenting with abnormal uterine bleeding (AUB). In the present study, we have evaluated the abdominal ultrasound of bonnet monkeys ( n = 8) showing spontaneous ovulatory ( n = 5) and anovulatory ( n = 3) AUB. The ovulatory ( n = 5) macaques showed cyclic AUB for 7-8 days. The anovulatory ( n = 3) macaques had irregular AUB with menstrual cycles of 40-45 days. The B-mode abdominal, colour Doppler and 3D ultrasound scans were performed during the proliferative phase of the menstrual cycle. Ultrasound examination revealed endometrial polyps in five macaques and endometrial hyperplasia in three animals. The width and length of endometrial polyps was around 0.5-1 cm (average 0.51 ± 0.23 cm × 0.96 ± 0.16 cm) with significant increase in endometrial thickness ( P < 0.0002). 3D ultrasound also showed a homogeneous mass in the uterine cavity and colour Doppler ultrasound showed increased vascularity in the endometrial polyps. Endometrial hyperplasia characteristically appeared as a thickened echogenic endometrium ( P < 0.0002). This study demonstrates the use of non-invasive ultrasound techniques in the diagnosis of AUB in macaques.
[Mh] Termos MeSH primário: Macaca radiata
Doenças dos Macacos/diagnóstico por imagem
Hemorragia Uterina/diagnóstico por imagem
[Mh] Termos MeSH secundário: Animais
Feminino
Doenças dos Macacos/etiologia
Ultrassonografia
Hemorragia Uterina/etiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170523
[Lr] Data última revisão:
170523
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160306
[St] Status:MEDLINE
[do] DOI:10.1177/0023677216637304


  6 / 723 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:26864769
[Au] Autor:Nelson MJ; Murthy A; Schall JD
[Ad] Endereço:Department of Psychology, Center for Integrative & Cognitive Neuroscience, Vanderbilt Vision Research Center, Vanderbilt University, Nashville, Tennessee; California Institute of Technology, Pasadena, California; and.
[Ti] Título:Neural control of visual search by frontal eye field: chronometry of neural events and race model processes.
[So] Source:J Neurophysiol;115(4):1954-69, 2016 Apr.
[Is] ISSN:1522-1598
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We investigated the chronometry of neural processes in frontal eye fields of macaques performing double-step saccade visual search in which a conspicuous target changes location in the array on a random fraction of trials. Durations of computational processes producing a saccade to original and final target locations (GO1 and GO2, respectively) are derived from response times (RT) on different types of trials. In these data, GO2 tended to be faster than GO1, demonstrating that inhibition of the initial saccade did not delay production of the compensated saccade. Here, we measured the dynamics of visual, visuomovement, and movement neuron activity in relation to these processes by examining trials when neurons instantiated either process. First, we verified that saccades were initiated when the discharge rate of movement neurons reached a threshold that was invariant across RT and trial type. Second, the time when visual and visuomovement neurons selected the target and when movement neuron activity began to accumulate were not significantly different across trial type. Third, the interval from the beginning of accumulation to threshold of movement-related activity was significantly shorter when instantiating the GO2 relative to the GO1 process. Differences observed between monkeys are discussed. Fourth, random variation of RT was accounted for to some extent by random variation in both the onset and duration of selective activity of each neuron type but mostly by variation of movement neuron accumulation duration. These findings offer new insights into the sources of control of target selection and saccade production in dynamic environments.
[Mh] Termos MeSH primário: Potenciais Evocados Visuais
Tempo de Reação
Movimentos Sacádicos
Campos Visuais
[Mh] Termos MeSH secundário: Animais
Lobo Frontal/citologia
Lobo Frontal/fisiologia
Macaca mulatta
Macaca radiata
Neurônios/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1612
[Cu] Atualização por classe:170403
[Lr] Data última revisão:
170403
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160413
[St] Status:MEDLINE
[do] DOI:10.1152/jn.01023.2014


  7 / 723 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:26735328
[Au] Autor:Coplan JD; Kolavennu V; Abdallah CG; Mathew SJ; Perera TD; Pantol G; Carpenter D; Tang C
[Ad] Endereço:Department of Psychiatry & Behavioral Sciences, SUNY Downstate Medical Center, Brooklyn, NY, USA. Electronic address: Jeremy.Coplan@Downstate.edu.
[Ti] Título:Patterns of anterior versus posterior white matter fractional anistotropy concordance in adult nonhuman primates: Effects of early life stress.
[So] Source:J Affect Disord;192:167-75, 2016 Mar 01.
[Is] ISSN:1573-2517
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Functional neuroimaging studies report global prefrontal dysconnectivity in mood disorders, supporting the notion of widespread disruptions in brain networks. Microscopic alterations in white matter (WM) tracts - which possess neuroplastic properties and play a central role in brain connectivity - are interrogated herein in the context of brain dysconnectivity. Early life stress (ELS), an antecedent to human mood disorders, induces WM alterations in volumetrics and integrity. We hypothesized that nonhuman primate infants exposed to ELS would exhibit persistent impairments in both frontal and posterior concordance of WM integrity, therefore contributing to global brain dysconnectivity. METHODS: Using a 3T MRI, diffusion tensor imaging (DTI) was performed on 21 adult male Bonnet macaques, 12 of whom had been raised under variable foraging demand (VFD) conditions and nine of whom had been raised under normative conditions (Non-VFD). As representative of anterior regions, fractional anisotropy (FA) concordance between anterior corpus callosum (ACorpusC) and anterior limb of the internal capsule (ALIC) was examined. For posterior regions, FA concordance between posterior corpus callosum (PCorpusC) and posterior limb of the internal capsule (PLICA) and between PCorpusC and occipital WM was examined. Examination of posterior FA was explored in the context of frontal markers of neuroplasticity. RESULTS: A concordant relationship for FA between left ALIC and ACorpusC was evident in Non-VFD-reared subjects, but significantly absent in VFD-reared subjects. For left posterior regions, FA concordance between PLICA and PCorpusC and occipital WM and PCorpusC was evident in VFD-reared and not Non-VFD-reared subjects. The posterior concordance in VFD was significantly distinguishable from the deficit in anterior concordance FA in VFD. CONCLUSIONS: The findings support the view that disrupted emotional integrity of the maternal-infant attachment process affects normative synchronous development of frontal white matter tracts but creates errant posterior concordance and also disrupts an inverse relationship between posterior white matter tracts and markers of neuroplasticity. We provide preliminary evidence that a concordant relationship between capsular-callosal FA may become discordant, providing a putative mechanism for prefrontal functional brain dysconnectivity.
[Mh] Termos MeSH primário: Estresse Psicológico/fisiopatologia
Substância Branca/fisiopatologia
[Mh] Termos MeSH secundário: Animais
Anisotropia
Encéfalo/fisiopatologia
Corpo Caloso/fisiopatologia
Imagem de Tensor de Difusão
Neuroimagem Funcional
Cápsula Interna
Macaca radiata
Imagem por Ressonância Magnética
Masculino
Transtornos do Humor/fisiopatologia
Plasticidade Neuronal
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Em] Mês de entrada:1609
[Cu] Atualização por classe:160125
[Lr] Data última revisão:
160125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160125
[St] Status:MEDLINE


  8 / 723 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:26547901
[Au] Autor:Puga-Gonzalez I; Cooper MA; Hemelrijk CK
[Ad] Endereço:Behavioural Ecology and Self-organization, Centre for Ecological and Evolutionary Studies, University of Groningen, Groningen, The Netherlands.
[Ti] Título:"Targeting or supporting, what drives patterns of aggressive intervention in fights?".
[So] Source:Am J Primatol;78(2):247-55, 2016 Feb.
[Is] ISSN:1098-2345
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:GrooFiWorld is an individual-based, computational model of social interactions that can be used to examine factors underlying reciprocation and interchange of social behavior in primate societies. Individuals within GrooFiWorld are programed to maintain spatial proximity and thereby form a group. When an individual encounters another individual in its proximity, the individual attacks the other if the risk of losing is low. Otherwise, the individual considers grooming the other. Patterns of social behavior that emerge in the model resemble empirical data from primates. Triadic aggression emerges when an individual attacks one of the former combatants by chance immediately after an aggressive interaction, and reciprocation and interchange of grooming and support emerge even though individuals have no intention to help others or pay back services. The model generates predictions for patterns of contra-intervention that are counterintuitive within a framework of interchange of social services, such as that individuals receive more contra-intervention from those whom they groom more frequently. Here we tested these predictions in data collected on social interactions in a group of bonnet macaques (Macaca radiata). We confirmed the predictions of the model in the sense that contra-intervention was strongly correlated with dyadic aggression which suggests that contra-intervention is a subset of dyadic aggression. Adult females directed more contra-intervention to those individuals from whom they received more grooming. Further, contra-intervention was directed down the dominance hierarchy such that adult females received more contra-intervention from higher ranking females. Because these findings are consistent with the predictions from the GrooFiWorld model, they suggest that the distribution of interventions in fights is regulated by factors such as dominance rank and spatial structure rather than a motivation to help others and interchange social services.
[Mh] Termos MeSH primário: Agressão
Asseio Animal
Macaca radiata/fisiologia
Comportamento Social
[Mh] Termos MeSH secundário: Animais
Simulação por Computador
Feminino
Macaca radiata/parasitologia
Masculino
Modelos Biológicos
Predomínio Social
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Em] Mês de entrada:1610
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160119
[St] Status:MEDLINE
[do] DOI:10.1002/ajp.22505


  9 / 723 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:25326245
[Au] Autor:Liao CC; Qi HX; Reed JL; Miller DJ; Kaas JH
[Ad] Endereço:301 Wilson Hall, Department of Psychology, Vanderbilt University, 111 21st Avenue South, Nashville, TN, 37212, USA. chia-chi.liao@vanderbilt.edu.
[Ti] Título:Congenital foot deformation alters the topographic organization in the primate somatosensory system.
[So] Source:Brain Struct Funct;221(1):383-406, 2016 Jan.
[Is] ISSN:1863-2661
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Limbs may fail to grow properly during fetal development, but the extent to which such growth alters the nervous system has not been extensively explored. Here we describe the organization of the somatosensory system in a 6-year-old monkey (Macaca radiata) born with a deformed left foot in comparison to the results from a normal monkey (Macaca fascicularis). Toes 1, 3, and 5 were missing, but the proximal parts of toes 2 and 4 were present. We used anatomical tracers to characterize the patterns of peripheral input to the spinal cord and brainstem, as well as between thalamus and cortex. We also determined the somatotopic organization of primary somatosensory area 3b of both hemispheres using multiunit electrophysiological recording. Tracers were subcutaneously injected into matching locations of each foot to reveal their representations within the lumbar spinal cord, and the gracile nucleus (GrN) of the brainstem. Tracers injected into the representations of the toes and plantar pads of cortical area 3b labeled neurons in the ventroposterior lateral nucleus (VPL) of the thalamus. Contrary to the orderly arrangement of the foot representation throughout the lemniscal pathway in the normal monkey, the plantar representation of the deformed foot was significantly expanded and intruded into the expected representations of toes in the spinal cord, GrN, VPL, and area 3b. We also observed abnormal representation of the intact foot in the ipsilateral spinal cord and contralateral area 3b. Thus, congenital malformation influences the somatotopic representation of the deformed as well as the intact foot.
[Mh] Termos MeSH primário: Cérebro/fisiopatologia
Deformidades Congênitas do Pé/veterinária
/inervação
Doenças dos Macacos/fisiopatologia
Plasticidade Neuronal
Córtex Somatossensorial/fisiopatologia
[Mh] Termos MeSH secundário: Potenciais de Ação
Animais
Mapeamento Encefálico/veterinária
Tronco Encefálico/fisiopatologia
Eletroencefalografia/veterinária
Deformidades Congênitas do Pé/fisiopatologia
Macaca fascicularis
Macaca radiata
Vias Neurais/fisiopatologia
Técnicas de Rastreamento Neuroanatômico/veterinária
Medula Espinal/fisiopatologia
Tálamo/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Em] Mês de entrada:1610
[Cu] Atualização por classe:170101
[Lr] Data última revisão:
170101
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160121
[St] Status:MEDLINE
[do] DOI:10.1007/s00429-014-0913-7


  10 / 723 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
PubMed Central Texto completo
Texto completo
[PMID]:26500504
[Au] Autor:Jiang Y; Purushothaman G; Casagrande VA
[Ad] Endereço:Department of Psychology, Vanderbilt University Nashville, TN, USA.
[Ti] Título:A computational relationship between thalamic sensory neural responses and contrast perception.
[So] Source:Front Neural Circuits;9:54, 2015.
[Is] ISSN:1662-5110
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Uncovering the relationship between sensory neural responses and perceptual decisions remains a fundamental problem in neuroscience. Decades of experimental and modeling work in the sensory cortex have demonstrated that a perceptual decision pool is usually composed of tens to hundreds of neurons, the responses of which are significantly correlated not only with each other, but also with the behavioral choices of an animal. Few studies, however, have measured neural activity in the sensory thalamus of awake, behaving animals. Therefore, it remains unclear how many thalamic neurons are recruited and how the information from these neurons is pooled at subsequent cortical stages to form a perceptual decision. In a previous study we measured neural activity in the macaque lateral geniculate nucleus (LGN) during a two alternative forced choice (2AFC) contrast detection task, and found that single LGN neurons were significantly correlated with the monkeys' behavioral choices, despite their relatively poor contrast sensitivity and a lack of overall interneuronal correlations. We have now computationally tested a number of specific hypotheses relating these measured LGN neural responses to the contrast detection behavior of the animals. We modeled the perceptual decisions with different numbers of neurons and using a variety of pooling/readout strategies, and found that the most successful model consisted of about 50-200 LGN neurons, with individual neurons weighted differentially according to their signal-to-noise ratios (quantified as d-primes). These results supported the hypothesis that in contrast detection the perceptual decision pool consists of multiple thalamic neurons, and that the response fluctuations in these neurons can influence contrast perception, with the more sensitive thalamic neurons likely to exert a greater influence.
[Mh] Termos MeSH primário: Comportamento de Escolha/fisiologia
Simulação por Computador
Sensibilidades de Contraste/fisiologia
Corpos Geniculados/fisiologia
Modelos Neurológicos
Neurônios/fisiologia
[Mh] Termos MeSH secundário: Animais
Macaca mulatta
Macaca radiata
Masculino
Probabilidade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1607
[Cu] Atualização por classe:161019
[Lr] Data última revisão:
161019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151027
[St] Status:MEDLINE
[do] DOI:10.3389/fncir.2015.00054



página 1 de 73 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde