Base de dados : MEDLINE
Pesquisa : B01.050.500.131.166.132.419.575 [Categoria DeCS]
Referências encontradas : 175 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 18 ir para página                         

  1 / 175 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29374118
[Au] Autor:Busin V
[Ad] Endereço:DVM, PhD, DipECSRHM, MRCVS, School of Veterinary Medicine, University of Glasgow, 464 Bearsden Road, Glasgow, UK.
[Ti] Título:Treatment of sheep scab in the UK: preventing the spread of resistant mites.
[So] Source:Vet Rec;182(4):104-105, 2018 01 27.
[Is] ISSN:2042-7670
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Infestações por Ácaros/prevenção & controle
Ácaros
[Mh] Termos MeSH secundário: Animais
Psoroptidae
Ovinos
Doenças dos Ovinos/prevenção & controle
Reino Unido
[Pt] Tipo de publicação:JOURNAL ARTICLE; COMMENT
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180128
[St] Status:MEDLINE
[do] DOI:10.1136/vr.k422


  2 / 175 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28395753
[Au] Autor:Becskei C; Reinemeyer C; King VL; Lin D; Myers MR; Vatta AF
[Ad] Endereço:Zoetis, Veterinary Medicine Research and Development, Mercuriusstraat 20, Zaventem, B-1930, Belgium. Electronic address: csilla.becskei@zoetis.com.
[Ti] Título:Efficacy of a new spot-on formulation of selamectin plus sarolaner in the treatment of Otodectes cynotis in cats.
[So] Source:Vet Parasitol;238 Suppl 1:S27-S30, 2017 Apr.
[Is] ISSN:1873-2550
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The efficacy of a new spot-on formulation of selamectin/sarolaner was evaluated against induced Otodectes cynotis infestations in cats in two randomized, blinded studies. Fourteen and 16 cats were randomly assigned to treatment groups in Studies 1 and 2, respectively. On Day 0, animals were either treated with placebo or with the spot-on formulation at the minimal dose of 6.0mg selamectin and 1.0mg sarolaner per kg bodyweight. Treatments were administered topically at the base of the neck. Presence of live mites was evaluated 14days after treatment administration by otoscopic examination and total live mite counts (adults plus immature) were conducted on Day 30 by ear lavage. Efficacy was calculated based on the reduction of mean total live mite counts on Day 30 in the selamectin/sarolaner-treated group versus the placebo-treated group. There were no treatment-related adverse reactions during the studies, apart from one cat in each treatment group with alopecia at the administration site. In both studies combined, live mites were present on Day 14, in 14 out of 15 cats in the placebo-treated groups and in 2 out of 15 cats in the selamectin/sarolaner-treated groups. On Day 30, the arithmetic mean live mite counts were 576.9 and 875.8 in the placebo-treated groups and 5.8 and 4.7 in the selamectin/sarolaner-treated groups, in Studies 1 and 2, respectively. The live mite counts were significantly (P≤0.0021) lower in the selamectin/sarolaner-treated groups compared to the placebo-treated groups with efficacies of 99.2% and 99.3%, in Studies 1 and 2 respectively. A single administration of a new spot-on formulation of selamectin/sarolaner at the minimum dose was safe and highly efficacious in the treatment of ear mite infestations in cats.
[Mh] Termos MeSH primário: Doenças do Gato/tratamento farmacológico
Isoxazóis/administração & dosagem
Ivermectina/análogos & derivados
Infestações por Ácaros/veterinária
[Mh] Termos MeSH secundário: Administração Tópica
Animais
Antiparasitários/administração & dosagem
Gatos
Feminino
Ivermectina/administração & dosagem
Masculino
Infestações por Ácaros/tratamento farmacológico
Carga Parasitária
Psoroptidae
Distribuição Aleatória
Fatores de Tempo
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antiparasitic Agents); 0 (Isoxazoles); 70288-86-7 (Ivermectin); A2669OWX9N (selamectin)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170418
[Lr] Data última revisão:
170418
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170412
[St] Status:MEDLINE


  3 / 175 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28342673
[Au] Autor:Dunstand-Guzmán E; Hallal-Calleros C; Morales-Montor J; Hernández-Velázquez VM; Zárate-Ramos JJ; Hoffman KL; Peña-Chora G; Flores-Pérez FI
[Ad] Endereço:Centro de Investigación en Biotecnología, Universidad Autónoma del Estado de Morelos, Av. Universidad 1001, Col. Chamilpa, 62209, Cuernavaca, Morelos, Mexico. Electronic address: dunstand_ipalogy@outlook.com.
[Ti] Título:Therapeutic use of Bacillus thuringiensis in the treatment of psoroptic mange in naturally infested New Zealand rabbits.
[So] Source:Vet Parasitol;238:24-29, 2017 Apr 30.
[Is] ISSN:1873-2550
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Bacillus thuringiensis is a bacteria known for its bioinsecticidal toxins and it has been proposed as an alternative in the treatment of several parasites that infect domestic animals (helminths, ticks, mites). In this work, we evaluated the clinical efficiency of the Bacillus thuringiensis GP532 strain in the treatment of six rabbits naturally infested with the P. cuniculi mite. GP532 extract (10mg/ml) was applied by aspersion in both pinna, with a second application after seven days, and the therapeutic effect was measured in both qualitative and quantitative manner. GP532 application resulted in a decreased infestation rate, which was observed as early as 3days post-treatment. At day 14, a decrease from 4.66±0.61 to 0.50±0.10 in the left pinna and from 1.66±0.21 to 0.66±0.16 (P<0.05) in the right pinna was observed. This response was comparable to the commercial drug Ivermectin, which induced a decreased infestation rate from 4.00±0.51 to 0.16±0.10 in the left pinna and from 4.66±0.80 to 0.25±0.11 in the right pinna (P<0.05). At day 30 post-treatment, GP532 decreased the total infested area by 76.80±16.06%, whereas Ivermectin resulted in a 97.41±0.99% decrease. Neither treatment produced irritation or macroscopic lesions. Our results show that the B. thuringiensis GP532 strain has a therapeutic potential in the treatment of psoroptic mange in rabbits.
[Mh] Termos MeSH primário: Bacillus thuringiensis/fisiologia
Infestações por Ácaros/veterinária
Psoroptidae/microbiologia
Coelhos/parasitologia
[Mh] Termos MeSH secundário: Animais
Agentes de Controle Biológico
Interações Hospedeiro-Patógeno
Infestações por Ácaros/parasitologia
Infestações por Ácaros/terapia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biological Control Agents)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170327
[St] Status:MEDLINE


  4 / 175 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28288764
[Au] Autor:Guo X; Shang X; Li B; Zhou XZ; Wen H; Zhang J
[Ad] Endereço:Key Laboratory of New Animal Drug Project of Gansu Province, Key Laboratory of Veterinary Pharmaceutical Development of Ministry of Agriculture, Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Lanzhou 730050, PR China.
[Ti] Título:Acaricidal activities of the essential oil from Rhododendron nivale Hook. f. and its main compund, δ-cadinene against Psoroptes cuniculi.
[So] Source:Vet Parasitol;236:51-54, 2017 Mar 15.
[Is] ISSN:1873-2550
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:In this paper, the acaricidal activities of Rhododendron nivale Hook. f. and its main compound, δ-cadinene were investigated, and the chemical composition of the essential oil was analyzed. The results showed that among aqueous, 70% ethanols, acetic ether, chloroform, petroleum ether and essential oil extracts from the shoots and leaves, the essential oil showed the best in vitro acaricidal activity against adult P. cuniculi, which occurred in a concentration- and time-dependent manner. The median lethal time (LT ) values of four concentrations (33.33-4.17mg/ml) of the essential oil ranged from 1.476 to 25.900h, respectively. After the treatment of P. cuniculi with the essential oil and ivermectin, infected rabbits were free of scabs or secretions in the ear canal by day 20. Then, the percent yield of essential oil from the leaves and shoots was 2.45% (w/w), which includes 50 compounds. The primary component identified was terpenes, and among of compounds identified from the essential oil of R. nivale the highest relative content was δ-cadinene, which also presented the marked acaricidal activity against Psoroptes cuniculi in vitro. These findings provide evidence for the use of acaricides as a traditional medicine and indicate that the essential oil and δ-cadinene could be used to control mites in livestock.
[Mh] Termos MeSH primário: Acaricidas
Infestações por Ácaros/veterinária
Óleos Voláteis
Psoroptidae
Coelhos
Rhododendron/química
Sesquiterpenos
[Mh] Termos MeSH secundário: Animais
Cromatografia Gasosa-Espectrometria de Massas
Infestações por Ácaros/parasitologia
Infestações por Ácaros/prevenção & controle
Extratos Vegetais/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acaricides); 0 (Oils, Volatile); 0 (Plant Extracts); 0 (Sesquiterpenes); 0 (delta-cadinene)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170908
[Lr] Data última revisão:
170908
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170315
[St] Status:MEDLINE


  5 / 175 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28282989
[Au] Autor:Lu M; Xiong D; Sun W; Yu T; Hu Z; Ding J; Cai Y; Yang S; Pan B
[Ad] Endereço:a The Department of Veterinary Parasitology, College of Veterinary Medicine, China Agriculture University , Hai Dian District , Beijing , China.
[Ti] Título:Sustained release ivermectin-loaded solid lipid dispersion for subcutaneous delivery: in vitro and in vivo evaluation.
[So] Source:Drug Deliv;24(1):622-631, 2017 Nov.
[Is] ISSN:1521-0464
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This work aimed to develop a sustained release solid dispersion of ivermectin (IVM-SD) in a lipid matrix (hydrogenated castor oil, HCO) for subcutaneous delivery. Solvent-melting technology was employed to prepare IVM-SDs using HCO. The physicochemical properties of the IVM-SDs were evaluated by scanning electron microscopy (SEM), X-ray powder diffraction (XRPD), and Fourier transform infrared spectroscopy (FTIR). The release of IVM from IVM-SDs was evaluated with HPLC in vitro. Pharmacokinetics of IVM was studied in rabbits following a single subcutaneous administration of IVM-SD formulations. The efficacy of IVM-SD against the ear mange mite was evaluated in rabbits. IVM was completely dispersed in HCO in an amorphous state at a drug:carrier ratio lower than 1:3. No chemical interactions between drug and carrier were found besides hydrogen bonding for the amorphous IVM-SDs. The amorphous IVM-SDs formulations exhibited a sustained release of IVM versus physical mixtures (PMs) of IVM and HCO. The drug release decreased as the drug:carrier ratios decreased, and the release kinetics of IVM were controlled via diffusion. Cytotoxicity of IVM-SD to MDCK cells was lower than native IVM. The IVM plasma concentration of SD1:3 remained above 1 ng/mL for 49 d. Higher AUC, MRT, and T values were obtained at a SD1:3 relative to the IVM group. The IVM-SD improved almost 1.1-fold bioavailability of drug compared with IVM in rabbits. IVM-SD could provide longer persistence against rabbit's ear mites than a commercial IVM injection. This study shows that these solid lipid dispersions are a promising approach for the development of subcutaneous IVM formulations.
[Mh] Termos MeSH primário: Antiparasitários/administração & dosagem
Óleo de Rícino/química
Portadores de Fármacos
Ivermectina/administração & dosagem
Infestações por Ácaros/veterinária
Psoroptidae/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Antiparasitários/química
Antiparasitários/farmacocinética
Antiparasitários/toxicidade
Disponibilidade Biológica
Óleo de Rícino/análogos & derivados
Óleo de Rícino/toxicidade
Sobrevivência Celular/efeitos dos fármacos
Cromatografia Líquida de Alta Pressão
Cristalografia por Raios X
Preparações de Ação Retardada
Cães
Composição de Medicamentos
Hidrogenação
Injeções Subcutâneas
Ivermectina/química
Ivermectina/farmacocinética
Ivermectina/toxicidade
Células Madin Darby de Rim Canino
Masculino
Microscopia Eletrônica de Varredura
Infestações por Ácaros/tratamento farmacológico
Infestações por Ácaros/parasitologia
Difração de Pó
Coelhos
Solubilidade
Espectroscopia de Infravermelho com Transformada de Fourier
Tecnologia Farmacêutica/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antiparasitic Agents); 0 (Delayed-Action Preparations); 0 (Drug Carriers); 70288-86-7 (Ivermectin); 8001-79-4 (Castor Oil)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170321
[Lr] Data última revisão:
170321
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170312
[St] Status:MEDLINE
[do] DOI:10.1080/10717544.2017.1284945


  6 / 175 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28107880
[Au] Autor:Nixon EJ; Rose Vineer H; Wall R
[Ad] Endereço:Veterinary Parasitology and Ecology Group, University of Bristol, Bristol Life Sciences Building, 24 Tyndall Avenue, Bristol, BS8 1TQ, United Kingdom. Electronic address: Emily.Nixon@bristol.ac.uk.
[Ti] Título:Treatment strategies for sheep scab: An economic model of farmer behaviour.
[So] Source:Prev Vet Med;137(Pt A):43-51, 2017 Feb 01.
[Is] ISSN:1873-1716
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Ovine psoroptic mange (sheep scab) is a debilitating and damaging condition caused by a hypersensitivity reaction to the faecal material of the parasitic mite Psoroptes ovis. Farmers incur costs from the use of prophylactic acaricides and, if their sheep become infected, they incur the costs of therapeutic treatment plus the economic loss from reduced stock growth, lower reproductive rate, wool loss and hide damage. The unwillingness of farmers to use routine prophylactic treatment has been cited as a primary cause of the growing incidence of sheep scab in the United Kingdom (UK) since the disease was deregulated in 1992. However, if farmers behave rationally from an economic perspective, the optimum strategy that they should adopt will depend on the risk of infection and the relative costs of prophylactic versus therapeutic treatment, plus potential losses. This calculation is also complicated by the fact that the risk of infection is increased if neighbours have scab and reduced if neighbours treat prophylactically. Hence, for any farmer, the risk of infection and optimum approach to treatment is also contingent on the behaviour of neighbours, particularly when common grazing is used. Here, the relative economic costs of different prophylactic treatment strategies are calculated for upland and lowland farmers and a game theory model is used to evaluate the relative costs for a farmer and his/her neighbour under different risk scenarios. The analysis shows that prophylaxis with organophosphate (OP) dipping is a cost effective strategy, but only for upland farmers where the risk of infection is high. In all other circumstances prophylaxis is not cost effective relative to reliance on reactive (therapeutic) treatment. Hence, farmers adopting a reactive treatment policy only, are behaving in an economically rational manner. Prophylaxis and cooperation only become economically rational if the risk of scab infection is considerably higher than the current national average, or the cost of treatment is lower. Should policy makers wish to reduce the national prevalence of scab, economic incentives such as subsidising the cost of acaricides or rigorously applied financial penalties, would be required to make prophylactic treatment economically appealing to individual farmers. However, such options incur their own infrastructure and implementation costs for central government.
[Mh] Termos MeSH primário: Infestações por Ácaros/veterinária
Doenças dos Ovinos/prevenção & controle
[Mh] Termos MeSH secundário: Acaricidas/economia
Acaricidas/uso terapêutico
Criação de Animais Domésticos/economia
Criação de Animais Domésticos/métodos
Criação de Animais Domésticos/estatística & dados numéricos
Animais
Análise Custo-Benefício
Diazinon/economia
Diazinon/uso terapêutico
Macrolídeos/economia
Macrolídeos/uso terapêutico
Infestações por Ácaros/tratamento farmacológico
Infestações por Ácaros/economia
Infestações por Ácaros/prevenção & controle
Modelos Econômicos
Psoroptidae
Ovinos/parasitologia
Doenças dos Ovinos/tratamento farmacológico
Doenças dos Ovinos/economia
Reino Unido
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acaricides); 0 (Macrolides); 51570-36-6 (milbemycin); YUS1M1Q929 (Diazinon)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170517
[Lr] Data última revisão:
170517
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170122
[St] Status:MEDLINE


  7 / 175 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28093080
[Au] Autor:Taenzler J; de Vos C; Roepke RK; Frénais R; Heckeroth AR
[Ad] Endereço:MSD Animal Health Innovation GmbH, Zur Propstei, 55270, Schwabenheim, Germany. janina.taenzler@msd.de.
[Ti] Título:Efficacy of fluralaner against Otodectes cynotis infestations in dogs and cats.
[So] Source:Parasit Vectors;10(1):30, 2017 Jan 16.
[Is] ISSN:1756-3305
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The efficacy of fluralaner for the treatment of Otodectes cynotis infestations in dogs and cats was evaluated after oral (dogs) or topical administration (dogs and cats). Twenty-four dogs and sixteen cats were experimentally infested with O. cynotis and randomly allocated to equal sized groups (n = 8/group). Dog groups were treated once, either orally with fluralaner at a minimum dose of 25 mg/kg body weight, topically with fluralaner at a dose of 25 mg/kg body weight or topically with saline solution (control). Cat groups were treated once, either topically with fluralaner at a dose of 40 mg/kg body weight or topically with saline solution. Ears of all animals were examined otoscopically for live visible mites and the amount of debris and cerumen before, and 14 and 28 days after treatment. Twenty-eight days after treatment, animals were sedated and both ears were flushed to obtain the total number of live mites per animal. The efficacy was calculated, based on the results of the ear flushing, by comparing mean live mite counts in the fluralaner treated groups versus the saline solution treated group. RESULTS: A single topical treatment of cats with fluralaner reduced the mean mite counts by 100% (P < 0.001) at 28 days after treatment. Similarly, a single oral or topical treatment of dogs with fluralaner reduced the mean mite counts by 99.8% (P < 0.001) at 28 days after treatment. Cats treated topically with fluralaner had no mites visible during otoscopic examination at either 14 or 28 days after treatment. All dogs treated orally or topically with fluralaner had no mites visible during otoscopic examination at 28 days after treatment. At 14 days after treatment, only 1-2 mites were visible in three dogs (oral treatment: 2 dogs, topical treatment: 1 dog). All fluralaner-treated animals showed improvement in the amount of cerumen exudation compared with observations performed before treatment. No treatment related adverse events were observed in any dogs or cats enrolled in these studies. CONCLUSIONS: In this study, fluralaner administered topically to cats and orally or topically to dogs was highly effective against Otodectes cynotis mite infestations.
[Mh] Termos MeSH primário: Acaricidas/administração & dosagem
Doenças do Gato/tratamento farmacológico
Doenças do Cão/tratamento farmacológico
Isoxazóis/administração & dosagem
Infestações por Ácaros/veterinária
Psoroptidae/efeitos dos fármacos
[Mh] Termos MeSH secundário: Administração Tópica
Animais
Doenças do Gato/parasitologia
Gatos
Doenças do Cão/parasitologia
Cães
Feminino
Masculino
Infestações por Ácaros/tratamento farmacológico
Infestações por Ácaros/parasitologia
Psoroptidae/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (A1443 compound); 0 (Acaricides); 0 (Isoxazoles)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170515
[Lr] Data última revisão:
170515
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170118
[St] Status:MEDLINE
[do] DOI:10.1186/s13071-016-1954-y


  8 / 175 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:27938395
[Au] Autor:Carithers D; Crawford J; de Vos C; Lotriet A; Fourie J
[Ad] Endereço:Merial, Inc, 3239 Satellite Blvd, Duluth, 30096, GA, USA. doug.carithers@Merial.com.
[Ti] Título:Assessment of afoxolaner efficacy against Otodectes cynotis infestations of dogs.
[So] Source:Parasit Vectors;9(1):635, 2016 Dec 09.
[Is] ISSN:1756-3305
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The efficacy of a single 2.5 mg/kg dose of afoxolaner (NexGard®, Merial) against induced Otodectes cynotis infestations was assessed in eight afoxolaner-treated dogs, compared to eight untreated dogs. METHODS: After O. cynotis infestations were established and confirmed by otoscopic assessments in 16 dogs, all of the dogs were included in the study and allocated to two separate treatment groups. The first group of eight ear mite-infested dogs remained untreated, while afoxolaner was administered orally to the second group of dogs at the minimum recommended dose once on Day 0. Otoscopic assessments performed on all dogs (Days -7, -2, 14 and 28) confirmed the presence or absence of live mites throughout the study. No serious adverse events were recorded throughout the study, and no adverse events were likely related to the administration of NexGard. RESULTS: By Day 28, seven out of eight untreated dogs were still infested with ear mites, while only two out of eight afoxolaner-treated dogs were infested, with one and four ear mites, respectively. On Day 28, the reductions of mite counts in the afoxolaner-treated group versus those of the control dogs were 98.5% based on geometric means, and 99.4% based on arithmetic means. Significantly fewer (P < 0.05) live mites were present in the afoxolaner-treated group than the untreated group on Day 28. CONCLUSION: The results of this study demonstrated that a single oral administration of afoxolaner at the minimum recommended dose is highly effective (>98%) in treating dogs with induced O. cynotis infestations.
[Mh] Termos MeSH primário: Doenças do Cão/tratamento farmacológico
Inseticidas/uso terapêutico
Isoxazóis/uso terapêutico
Infestações por Ácaros/tratamento farmacológico
Naftalenos/uso terapêutico
Psoroptidae/efeitos dos fármacos
[Mh] Termos MeSH secundário: Administração Oral
Animais
Cães
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos/patologia
Inseticidas/efeitos adversos
Isoxazóis/efeitos adversos
Naftalenos/efeitos adversos
Otoscopia
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Insecticides); 0 (Isoxazoles); 0 (Naphthalenes); 02L07H6D0U (afoxolaner)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170929
[Lr] Data última revisão:
170929
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161213
[St] Status:MEDLINE


  9 / 175 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:27809902
[Au] Autor:He ML; Xu J; He R; Shen NX; Gu XB; Peng XR; Yang GY
[Ad] Endereço:Department of Parasitology, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, 611130, China.
[Ti] Título:Preliminary analysis of Psoroptes ovis transcriptome in different developmental stages.
[So] Source:Parasit Vectors;9(1):570, 2016 Nov 04.
[Is] ISSN:1756-3305
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Psoroptic mange is a chronic, refractory, contagious and infectious disease mainly caused by the mange mite Psoroptes ovis, which can infect horses, sheep, buffaloes, rabbits, other domestic animals, deer, wild camels, foxes, minks, lemurs, alpacas, elks and other wild animals. Features of the disease include intense pruritus and dermatitis, depilation and hyperkeratosis, which ultimately result in emaciation or death caused by secondary bacterial infections. The infestation is usually transmitted by close contact between animals. Psoroptic mange is widespread in the world. In this paper, the transcriptome of P. ovis is described following sequencing and analysis of transcripts from samples of larvae (i.e. the Pso_L group) and nymphs and adults (i.e. the Pso_N_A group). The study describes differentially expressed genes (DEGs) and genes encoding allergens, which help understanding the biology of P. ovis and lay foundations for the development of vaccine antigens and drug target screening. METHODS: The transcriptome of P. ovis was assembled and analyzed using bioinformatic tools. The unigenes of P. ovis from each developmental stage and the unigenes differentially between developmental stages were compared with allergen protein sequences contained in the allergen database website to predict potential allergens. RESULTS: We identified 38,836 unigenes, whose mean length was 825 bp. On the basis of sequence similarity with seven databases, a total of 17,366 unigenes were annotated. A total of 1,316 DEGs were identified, including 496 upregulated and 820 downregulated in the Pso_L group compared with the Pso_N_A group. We predicted 205 allergens genes in the two developmental stages similar to genes from other mites and ticks, of these, 14 were among the upregulated DEGs and 26 among the downregulated DEGs. CONCLUSION: This study provides a reference transcriptome of P. ovis in absence of a reference genome. The analysis of DEGs and putative allergen genes may lay the foundation for studies of functional genomics, immunity and gene expression profiles of this parasitic mite species.
[Mh] Termos MeSH primário: Psoroptidae/crescimento & desenvolvimento
Psoroptidae/genética
Transcriptoma
[Mh] Termos MeSH secundário: Alérgenos/genética
Animais
Antígenos/genética
Biologia Computacional
Descoberta de Drogas
Perfilação da Expressão Gênica
Larva/genética
Ninfa/genética
Análise de Sequência de RNA
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Allergens); 0 (Antigens)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171027
[Lr] Data última revisão:
171027
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161105
[St] Status:MEDLINE


  10 / 175 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27514892
[Au] Autor:Shang X; Wang Y; Zhou X; Guo X; Dong S; Wang D; Zhang J; Pan H; Zhang Y; Miao X
[Ad] Endereço:Key Laboratory of New Animal Drug Project of Gansu Province, Key Laboratory of Veterinary Pharmaceutical Development of Ministry of Agriculture, Lanzhou Institute of Husbandry and Pharmaceutical Sciences of Chinese Academy of Agricultural Science, Lanzhou 730050, PR China.
[Ti] Título:Acaricidal activity of oregano oil and its major component, carvacrol, thymol and p-cymene against Psoroptes cuniculi in vitro and in vivo.
[So] Source:Vet Parasitol;226:93-6, 2016 Aug 15.
[Is] ISSN:1873-2550
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Oregano oil possesses marked antioxidant and antimicrobial activity and is widely applied in animal husbandry. In the present study, we aimed to investigate the acaricidal activities of oregano oil and its major component, carvacrol, thymol and p-cymene against Psoroptes cuniculi in vitro and in vivo. The results revealed that oregano oil exhibited significant acaricidal effects against P. cuniculi that were dose- and time-dependent response. In in vitro test, concentrations of 0.05% and 0.02% (v/v) killed all of the mites within 1h and 6h, respectively. Moreover, 0.1mg/ml (w/v) carvacrol, 0.2mg/ml (w/v) thymol and 1% p-cymene (v/v) also possessed marked acaricidal activities, and compared with the control group, elicited mean mortalities of 84.00%, 96.00% and 66% at 24h, respectively. The median lethal times (LT50) against P. cuniculi of the concentrations of 0.02%, 0.01% and 0.005% (v/v) of oregano oil, thymol, carvacrol and p-cymene were 2.171h, 11.396h, 26.102h, and 4.424h, 8.957h and 15.201h, respectively. Meanwhile, twenty naturaly infested rabbits were used to four homogeneity groups: negative control (without treatment), positive control (treated with ivermectin), group treated with 1% of oregano oil and other group with 5% of oregano oil. All the treatments were topically. After the treatment of 1% and 5% oregano oil, the P. cuniculi were completely eliminated in the rabbits, and at the end of the test (day 20), the rabbits of all treatment groups exhibited favorable mental and physical statuses. These results indicated that oregano oil could be widely applied as a potential acaricidal agent in the treatment of animal acariasis in the future.
[Mh] Termos MeSH primário: Monoterpenos/farmacologia
Origanum/química
Óleos Vegetais/farmacologia
Psoroptidae/efeitos dos fármacos
Timol/farmacologia
[Mh] Termos MeSH secundário: Acaricidas/farmacologia
Análise de Variância
Animais
Relação Dose-Resposta a Droga
Infestações por Ácaros/tratamento farmacológico
Infestações por Ácaros/veterinária
Óleos Vegetais/química
Coelhos
Distribuição Aleatória
Relação Estrutura-Atividade
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acaricides); 0 (Monoterpenes); 0 (Plant Oils); 1G1C8T1N7Q (4-cymene); 3J50XA376E (Thymol); 9B1J4V995Q (carvacrol)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170912
[Lr] Data última revisão:
170912
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160813
[St] Status:MEDLINE



página 1 de 18 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde