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Pesquisa : B01.050.500.131.166.132.832.400.425 [Categoria DeCS]
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  1 / 3581 MEDLINE  
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[PMID]:29405689
[Au] Autor:Osipova TN; Grigoryeva LA; Samoylova EP; Shapar AO; Bychkova EM
[Ti] Título:[Influence of meteorological factors on the activity of the adult taiga tick (Ixodes persulcatus Sch., Ixodinae) in St. Petersburg and its environs].
[So] Source:Parazitologiia;51(2):143-57, 2017 Mar-Apr.
[Is] ISSN:0031-1847
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:The article deals with influence of meteorolical factors on the activity of the taiga tick Ixodes persulvatus Sch. in St. Petersburg and its environs. The results of correlation analysis of meteorological data (21 index) and data ticks collected in 1980-2012 allowed determining linear dependence between 11 meteorological indices an average amount of ticks. Factor analysis reduced dimentionality down to 3 indices: sum of temperatures higher than +5.0 °C, sum of precipitation higher than 5 mm per year, and Selyaninov hydrothermal coefficient. It was demonstrated that, at the background of the general tendency for the decrease of the average number of active ticks in the studied territories, correlation between the amount of ticks and meteorological indices can significantly vary as in the correlation density, so in the character and in dependence of microclimatic features of the collecting site. When variability of the mean abundance of ticks during years of investigation is low, the methods of collecting can significantly affect the results of the statistical analysis. This fact must be taken in consideration during prognosis of both dates of the beginning of epidemiological season and its intensity.
[Mh] Termos MeSH primário: Ixodes/fisiologia
[Mh] Termos MeSH secundário: Animais
Conceitos Meteorológicos
Dinâmica Populacional
Federação Russa
Estações do Ano
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180207
[St] Status:MEDLINE


  2 / 3581 MEDLINE  
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[PMID]:29401574
[Au] Autor:Nikitin AY; Morozov IM
[Ti] Título:[Exoskeleton anomalies among taiga tick males from populations of the Asiatic part of Russia].
[So] Source:Parazitologiia;51(1):38-44, 2017 Jan-Feb.
[Is] ISSN:0031-1847
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:The taiga tick (Icodes persulcatus, Schulze, 1930) is the main and most epidemiologically dangerous vector of tick-born encephalitis virus (TBEV) and Borrelia in most parts of Russia's territory (Alekseev et al., 2008). The purpose of this article is to describe the incidence rate of I. persulcatus males with exoskeleton anomalies in populations of the Asiatic part of Russia. A total of 2630 taiga tick males were morphologically analyzed. They were collected in Far Eastern, Siberian and Ural Federal Districts (respectively, FEFD, SFD, UFD) in 15 geographically remote locations. It is shown that in all populations there are adult ticks with impaired exoskeleton, among which two types dominate: twin dents at the back of conscutum (P11), and uneven surface of conscutum - a "shagreen skin" (P9). The frequency of abnormalities in males from the areas with temperate monsoon and temperate continental climate (FEFD) was definitely lower (6.5 ± 1.05 %), than in individuals from the territories of SFD (29.7 ± 1.03 %) and UFD (25.8 ± 3.93 %) with continental and sharply continental climate. FEFD territory is also characterized by a less number of males having two simultaneous exoskeleton anomalies. Similar district-preconditioned differences in the frequency of recorded body distortions are also typical of females, with a higher percentage of deviant individuals in comparison with males. Thus, the identified polymorphism of exoskeleton structure of the taiga tick may reflect the natural phenogeographical variability of this trait and might not be the result of human impact.
[Mh] Termos MeSH primário: Exoesqueleto/anormalidades
Ixodes/anatomia & histologia
[Mh] Termos MeSH secundário: Animais
Clima
Feminino
Ixodes/genética
Masculino
Fenótipo
Sibéria
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180206
[St] Status:MEDLINE


  3 / 3581 MEDLINE  
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[PMID]:29401575
[Au] Autor:Dokuchaev NE
[Ti] Título:[A case of the tick (Ixodidae) hiperinvasion of the tundra vole in magadan environs].
[So] Source:Parazitologiia;51(1):45-50, 2017 Jan-Feb.
[Is] ISSN:0031-1847
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:A case of tundra vole death as a result its hyperinvasion by ticks Ixodes angustus on the northern periphery of the Asiatic range of the parasite is given.
[Mh] Termos MeSH primário: Arvicolinae/parasitologia
Ixodes/patogenicidade
Infestações por Carrapato/parasitologia
[Mh] Termos MeSH secundário: Animais
Evolução Fatal
Ixodes/fisiologia
Masculino
Sibéria
Infestações por Carrapato/patologia
Tundra
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180206
[St] Status:MEDLINE


  4 / 3581 MEDLINE  
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[PMID]:28743676
[Au] Autor:Levy S
[Ti] Título:Northern Trek: The Spread of into Canada.
[So] Source:Environ Health Perspect;125(7):074002, 2017 07 24.
[Is] ISSN:1552-9924
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Vetores Aracnídeos
Ixodes
[Mh] Termos MeSH secundário: Animais
Canadá
Seres Humanos
Doença de Lyme
[Pt] Tipo de publicação:JOURNAL ARTICLE; COMMENT
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170727
[St] Status:MEDLINE
[do] DOI:10.1289/EHP2095


  5 / 3581 MEDLINE  
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[PMID]:29178531
[Au] Autor:Kwan JY; Griggs R; Chicana B; Miller C; Swei A
[Ad] Endereço:Department of Biology, San Francisco State University, San Francisco, CA, USA.
[Ti] Título:Vertical vs. horizontal transmission of the microbiome in a key disease vector, Ixodes pacificus.
[So] Source:Mol Ecol;26(23):6578-6589, 2017 Dec.
[Is] ISSN:1365-294X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Vector-borne pathogens are increasingly found to interact with the vector's microbiome, influencing disease transmission dynamics. However, the processes that regulate the formation and development of the microbiome are largely unexplored for most tick species, an emerging group of disease vectors. It is not known how much of the tick microbiome is acquired through vertical transmission vs. horizontally from the environment or interactions with bloodmeal sources. Using 16S rRNA sequencing, we examined the microbiome of Ixodes pacificus, the vector of Lyme disease in the western USA, across life stages and infection status. We also characterized microbiome diversity in field and laboratory-collected nymphal ticks to determine how the surrounding environment affects microbiome diversity. We found a decrease in both species richness and evenness as the tick matures from larva to adult. When the dominant Rickettsial endosymbiont was computationally removed from the tick microbial community, we found that infected nymphs had lower species evenness than uninfected ticks, suggesting that lower microbiome diversity is associated with pathogen transmission in wild-type ticks. Furthermore, laboratory-reared nymph microbiome diversity was found to be compositionally distinct and significantly depauperate relative to field-collected nymphs. These results highlight unique patterns in the microbial community of I. pacificus that is distinct from other tick species. We provide strong evidence that ticks acquire a significant portion of their microbiome through exposure to their environment despite a loss of overall diversity through life stages. We provide evidence that loss of microbial diversity is at least in part due to elimination of microbial diversity with bloodmeal feeding but other factors may also play a role.
[Mh] Termos MeSH primário: Ixodes/microbiologia
Microbiota
[Mh] Termos MeSH secundário: Animais
Biodiversidade
Borrelia/classificação
California
Vetores de Doenças
Feminino
Larva/microbiologia
Masculino
Ninfa/microbiologia
RNA Ribossômico 16S/genética
Rickettsia/classificação
Simbiose
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (RNA, Ribosomal, 16S)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE
[do] DOI:10.1111/mec.14391


  6 / 3581 MEDLINE  
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[PMID]:29320145
[Au] Autor:Krstic M; Stajkovic N; Lazic S
[Ti] Título:Prevalence of Borrelia burgdorferi sensu lato in Ixodes ricinus ticks and assessment of entomological risk index at localities in Belgrade.
[So] Source:Vojnosanit Pregl;73(9):817-24, 2016 Sep.
[Is] ISSN:0042-8450
[Cp] País de publicação:Serbia
[La] Idioma:eng
[Ab] Resumo:Background/Aim: The first case of human Lyme borreliosis (LB) in Serbia was recorded in 1987. The number of reported LB cases has increased in the past decade. The aim of this study was to estimate the density of Ixodes ricinus (I. ricinus) ticks, the prevalence of Borrelia burgdorferi sensu lato (B. burgdorferi) in them, and entomological risk index (ERI) at 19 Belgrade localities which were grouped into three categories (forests, parkforests, parks). The values of ERI were compared with the number of tick bites in humans. Methods: Ticks were collected monthly by using the flag hours method and the infection rate was determined by using dark field microscopy. The ERI value was calculated for each locality where the ticks were collected. The related data about tick bites was obtained from the patient protocol of the Institute of Epidemiology, Military Medical Academy, Belgrade. Results: The total number of collected ticks, the number of nymphs and the infection rates of the nymphs were significantly higher in forests (p < 0.05) than park-forests and parks. Statistically, the ERI value was significantly higher in forests than parks of Belgrade (χ2 = 7.78, p < 0.01). In March and July, the ERI value was also significantly higher in forests, than park-forests (p < 0.01) and parks (p < 0.01). May was the month with the highest ERI value in each ecological category (forests p < 0.05; park-forests p < 0.01; parks p < 0.001). However, the number of tick bites in humans did not correlate with ERI values. Conclusion: The obtained results indicate that the risk of tick bite and human exposure to B. burgdorferi sensu lato is present at all selected localities in Belgrade. For a more comprehensive Lyme disease risk assessment the method of entomological risk index assessment should be combined with other methods, taking into consideration all tick stages and the behaviour and habits of people who may get infected B. burgdorferi sensu lato.
[Mh] Termos MeSH primário: Borrelia burgdorferi/isolamento & purificação
Ixodes/microbiologia
Ixodes/parasitologia
Doença de Lyme/microbiologia
Picadas de Carrapatos/microbiologia
Zoonoses/microbiologia
[Mh] Termos MeSH secundário: Animais
Florestas
Seres Humanos
Doença de Lyme/diagnóstico
Doença de Lyme/epidemiologia
Doença de Lyme/transmissão
Parques Recreativos
Medição de Risco
Fatores de Risco
Estações do Ano
Sérvia/epidemiologia
Picadas de Carrapatos/diagnóstico
Picadas de Carrapatos/epidemiologia
Fatores de Tempo
Saúde da População Urbana
Zoonoses/diagnóstico
Zoonoses/epidemiologia
Zoonoses/transmissão
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180111
[St] Status:MEDLINE
[do] DOI:10.2298/VSP150115069K


  7 / 3581 MEDLINE  
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[PMID]:29323856
[Au] Autor:Mel'nikova OV; Adel'shin RV; Korzun VM; Trushina YN; Andaev EI
[Ti] Título:Tick-borne encephalitis virus isolates from natural foci of the Irkutsk region: clarification of the genotype landscape.
[So] Source:Vopr Virusol;61(5):229-34, 2016.
[Is] ISSN:0507-4088
[Cp] País de publicação:Russia (Federation)
[La] Idioma:eng
[Ab] Resumo:The Irkutsk region is the unique territory where all known subtypes of tick-borne encephalitis virus (TBEV) circulate. In the last years, the phenomenon of changes in TBEV subtypes (substitution of the Far-Eastern subtype by the Siberian one) was noted in some regions of the Russian Federation. The results of individual investigation of 11522 Ixodes persulcatus ticks and brain specimens from 81 small mammals collected in natural foci of the Irkutsk region during 2006-2014 are presented in the article. More than 60 TBEV strains have been isolated and studied by virological methods; E gene fragments (1193 b.p.) of 68 isolates have been typed. The majority of the strains (irrespective of subtype) were of high virulence for laboratory mice (LM) in case of both intracerebral and subcutaneous inoculation of virus. All isolates from warm-blooded small mammals and humans were of high virulence for LM, but placed in the same clusters of the phylogenetic tree with ticks collected in the same area. Tick-borne strains of different virulence also did not form separate clusters on the tree. Phylogenetic analysis showed that modern TBEV genotypic landscape of the studied territory is changing toward absolute predominance of the Siberian subtype (94.1%). This subtype is represented by two groups with prototype strains "Zausaev" and "Vasilchenko". The "Vasilchenko" group of strains is spread on the whole territory under study; the strains of "Zausaev" group were isolated previously in the Irkutsk suburbs. The European subtype of TBEV circulates in natural foci of Pribaikalie permanently (at least 5% of the random sampling); the strains are of high virulence for LM. The Far-Eastern TBEV subtype was not found within the group of isolates collected in 20062014. The phylogenetic relationship of the strains under study had a higher correlation with the place of isolation than with the year or source.
[Mh] Termos MeSH primário: Vírus da Encefalite Transmitidos por Carrapatos/genética
Encefalite Transmitida por Carrapatos/epidemiologia
Encefalite Transmitida por Carrapatos/veterinária
Genoma Viral
Genótipo
Ixodes/virologia
[Mh] Termos MeSH secundário: Animais
Vetores de Doenças
Vírus da Encefalite Transmitidos por Carrapatos/classificação
Vírus da Encefalite Transmitidos por Carrapatos/isolamento & purificação
Encefalite Transmitida por Carrapatos/transmissão
Encefalite Transmitida por Carrapatos/virologia
Feminino
Seres Humanos
Mamíferos/virologia
Camundongos
Filogenia
Sibéria/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180208
[Lr] Data última revisão:
180208
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180112
[St] Status:MEDLINE


  8 / 3581 MEDLINE  
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[PMID]:29323844
[Au] Autor:Pukhovskaya NM; Morozova OV; Belozerova NB; Bakhmetyeva SV; Vysochina NP; Zdanovskaya NI; Ivanov LI
[Ti] Título:Comparative analysis of genomes of tick-borne encephalitis virus strains isolated from mosquitoes and ticks.
[So] Source:Vopr Virusol;62(1):30-5, 2017.
[Is] ISSN:0507-4088
[Cp] País de publicação:Russia (Federation)
[La] Idioma:eng
[Ab] Resumo:The tick-borne encephalitis virus (TBEV) strain Lazo MP36 was isolated from the pool of mosquitoes Aedes vexans collected in Lazo region of Khabarovsk territory in August 2014. Phylogenetic analysis of the strain Lazo MP36 complete genome (GenBank accession number KT001073) revealed its correspondence to the TBEV Far Eastern subtype and differences from the following strains: 1) from ticks Ixodes persulcatus P. Schulze, 1930 [vaccine strain 205 (JX498939) and strains Khekhtzir 1230 (KF880805), Chichagovka (KP844724), Birobidzhan 1354 (KF880805) isolated in 2012-2013]; 2) from mosquitoes [strain Malyshevo (KJ744034) isolated in 1978 from Aedes vexans nipponii in Khabarovsk territory; strain Sakhalin 6-11 isolated from the pool of mosquitoes in 2011 (KF826916)]; 3) from human brain [vaccine strain Sofjin (JN229223), Glubinnoe/2004(DQ862460). Kavalerovo (DQ862460), Svetlogorie (DQ862460)]. The fusion peptide necessary for flavivirus entry to cells of the three TBEV strains isolated from mosquitoes (Lazo MP36, Malyshevo and Sakhalin 6-11) has the canonical structure 98-DRGWGNHCGLFGKGSI-113 for the tick-borne flaviviruses. Amino acid transition H104G typical for the mosquito-borne flaviviruses was not found. Structures of 5'- and 3'-untranslated (UTR) regions of the TBEV strains from mosquitoes were 85-98% homologous to the TBEV strains of all subtypes without recombination with mosquito-borne flaviviruses found in the Far East of Russia. Secondary structures of 5'- and 3'-UTR as well as cyclization sequences (CS) of types a and B are highly homologous for all TBEV isolates independently of the biological hosts and vectors. similarity of the genomes of the TBEV isolates from mosquitoes, ticks and patients as well as pathogenicity of the isolates for new-borne laboratory mice and tissue cultures might suggest a possible role of mosquitoes in the TBEV circulation in natural foci as an accidental or additional virus carrier.
[Mh] Termos MeSH primário: Aedes/virologia
Vírus da Encefalite Transmitidos por Carrapatos/genética
Encefalite Transmitida por Carrapatos/epidemiologia
Genoma Viral
Ixodes/virologia
RNA Viral/genética
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Animais
Animais Recém-Nascidos
Vetores de Doenças
Cães
Vírus da Encefalite Transmitidos por Carrapatos/classificação
Vírus da Encefalite Transmitidos por Carrapatos/isolamento & purificação
Encefalite Transmitida por Carrapatos/transmissão
Encefalite Transmitida por Carrapatos/virologia
Extremo Oriente/epidemiologia
Genótipo
Seres Humanos
Camundongos
Camundongos Endogâmicos ICR
Conformação de Ácido Nucleico
Filogenia
RNA Viral/química
RNA Viral/isolamento & purificação
Roedores/virologia
Alinhamento de Sequência
Homologia de Sequência de Aminoácidos
Sibéria/epidemiologia
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (RNA, Viral)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180208
[Lr] Data última revisão:
180208
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180112
[St] Status:MEDLINE


  9 / 3581 MEDLINE  
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[PMID]:29281675
[Au] Autor:Clow KM; Leighton PA; Ogden NH; Lindsay LR; Michel P; Pearl DL; Jardine CM
[Ad] Endereço:Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada.
[Ti] Título:Northward range expansion of Ixodes scapularis evident over a short timescale in Ontario, Canada.
[So] Source:PLoS One;12(12):e0189393, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The invasion of the blacklegged tick, Ixodes scapularis into Ontario, Canada poses a significant risk to public health because it is a vector for numerous pathogens, including Borrelia burgdorferi sensu stricto, the causative agent of Lyme disease. Baseline field sampling in 2014 and 2015 detected I. scapularis and B. burgdorferi at sites across southern, eastern and central Ontario, including a hot spot in eastern Ontario. A "speed of spread" model for I. scapularis developed by Leighton and colleagues (2012) estimated that the tick's range was expanding northward at 46 km/year. In 2016, we revisited a subset of sites sampled in 2014 and 2015 to understand the changing nature of risk, and assess whether the rate of tick invasion is consistent with the speed of spread estimate. Ticks were collected via tick dragging at 17 out of 36 sites, 5 of which were new sites for I. scapularis. Samples were positive for B. burgdorferi at 8 sites. No other I. scapularis-borne pathogens were detected. Centrographic statistics revealed an increase in the dispersion of I. scapularis positive sites in eastern Ontario. Field data for each site were then compared to the model's predicted year of establishment for each census subdivision. Our findings illustrate that the range expansion of I. scapularis and the emergence of B. burgdorferi is ongoing, and provide short timescale evidence of the processes associated with I. scapularis spread. The range front appears to be moving at a rate of ~46 km/year, with colonization of the tick behind this range front occurring at a slower and heterogeneous rate. Assessment of site-level ecological factors did not provide any insight into the underlying processes that may be influencing the colonization of I. scapularis in specific areas. Ongoing field sampling is needed to monitor this dynamic process. This study highlights the current geographic risk associated with Lyme disease, which can be used to target public health interventions to the areas of greatest risk.
[Mh] Termos MeSH primário: Ixodes/fisiologia
[Mh] Termos MeSH secundário: Animais
Vetores Aracnídeos
Borrelia burgdorferi/isolamento & purificação
Ixodes/microbiologia
Doença de Lyme/transmissão
Ontário
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180129
[Lr] Data última revisão:
180129
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171228
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189393


  10 / 3581 MEDLINE  
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[PMID]:29236732
[Au] Autor:Embers ME; Hasenkampf NR; Jacobs MB; Tardo AC; Doyle-Meyers LA; Philipp MT; Hodzic E
[Ad] Endereço:Division of Bacteriology and Parasitology, Tulane National Primate Research Center, Tulane University Health Sciences Center, Covington, LA, United States of America.
[Ti] Título:Variable manifestations, diverse seroreactivity and post-treatment persistence in non-human primates exposed to Borrelia burgdorferi by tick feeding.
[So] Source:PLoS One;12(12):e0189071, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The efficacy and accepted regimen of antibiotic treatment for Lyme disease has been a point of significant contention among physicians and patients. While experimental studies in animals have offered evidence of post-treatment persistence of Borrelia burgdorferi, variations in methodology, detection methods and limitations of the models have led to some uncertainty with respect to translation of these results to human infection. With all stages of clinical Lyme disease having previously been described in nonhuman primates, this animal model was selected in order to most closely mimic human infection and response to treatment. Rhesus macaques were inoculated with B. burgdorferi by tick bite and a portion were treated with recommended doses of doxycycline for 28 days at four months post-inoculation. Signs of infection, clinical pathology, and antibody responses to a set of five antigens were monitored throughout the ~1.2 year study. Persistence of B. burgdorferi was evaluated using xenodiagnosis, bioassays in mice, multiple methods of molecular detection, immunostaining with polyclonal and monoclonal antibodies and an in vivo culture system. Our results demonstrate host-dependent signs of infection and variation in antibody responses. In addition, we observed evidence of persistent, intact, metabolically-active B. burgdorferi after antibiotic treatment of disseminated infection and showed that persistence may not be reflected by maintenance of specific antibody production by the host.
[Mh] Termos MeSH primário: Borrelia burgdorferi/fisiologia
Ixodes/microbiologia
Primatas/parasitologia
[Mh] Termos MeSH secundário: Animais
Ixodes/fisiologia
Camundongos
Picadas de Carrapatos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180116
[Lr] Data última revisão:
180116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171214
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189071



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