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[PMID]: | 29378554 |
[Au] Autor: | Nesa ML; Karim SMS; Api K; Sarker MMR; Islam MM; Kabir A; Sarker MK; Nahar K; Asadujjaman M; Munir MS |
[Ad] Endereço: | Department of Pharmacy, Atish Dipankar University of Science and Technology, Dhaka, Bangladesh. luthfunnesa_ph@yahoo.com. |
[Ti] Título: | Screening of Baccaurea ramiflora (Lour.) extracts for cytotoxic, analgesic, anti-inflammatory, neuropharmacological and antidiarrheal activities. |
[So] Source: | BMC Complement Altern Med;18(1):35, 2018 Jan 30. | [Is] ISSN: | 1472-6882 |
[Cp] País de publicação: | England |
[La] Idioma: | eng |
[Ab] Resumo: | BACKGROUND: It has been observed that the various part of Baccaurea ramiflora plant is used in rheumatoid arthritis, cellulitis, abscesses, constipation and injuries. This plant also has anticholinergic, hypolipidemic, hypoglycemic, antiviral, antioxidant, diuretic and cytotoxic activities. The present studyaimed to assess the cytotoxic, analgesic, anti-inflammatory, CNS depressant and antidiarrheal activities of methanol extract of Baccaurea ramiflora pulp and seeds in mice model. METHODS: The cytotoxic activity was determined by brine shrimp lethality bioassay; anti-nociceptive activity was determined by acetic acid-induced writhing, formalin- induced licking and biting, and tail immersion methods. The anti-inflammatory, CNS depressant and anti-diarrheal activities were assessed by carrageenan-induced hind paw edema, the open field and hole cross tests, and castor oil-induced diarrheal methods, respectively. The data were analyzed by one way ANOVA (analysis of variance) followed by Dunnett's test. RESULTS: In brine shrimp lethality bioassay, the LC values of the methanol extracts of Baccaurea ramiflora pulp and seed were 40 µg/mL and 10 µg/mL, respectively. Our investigation showed that Baccaurea ramiflora pulp and seed extracts (200 mg/kg) inhibited acetic acid induced pain 67.51 and 66.08%, respectively (p < 0.05) that was strongly comparable with that of Ibuprofen (72%) (p < 0.05). The Baccaurea ramiflora pulp and seed extracts (200 mg/kg) significantly (p < 0.05) reduced 58.5 and 53.4 in early and 80.8%, 76.61% in late phase of formalin-induced licking and biting. At 60 and 90 min pulp and seed extracts (200 mg/kg) inhibited nociception of thermal stimulus 50.16 and 62.4%, respectively (p < 0.05) which was comparable with the standard (morphine, 75.9% inhibition). The pulp and seed extracts (200 mg/kg) significantly (p < 0.05) reduced inflammation (42.00 and 55.22%, respectively) in carrageenan-induced hind paw edema and defecations (59.7 and 63.03%, respectively) in castor oil induced diarrhea. Both the extracts showed high sedative activity at 30, 60, 90, and 120 min. CONCLUSION: Our investigation demonstrated significant cytotoxic, analgesic, anti-inflammatory, CNS depressant and antidiarrheal activities of methanol extract of Baccaurea ramiflora pulp and seeds (200 mg/kg). |
[Mh] Termos MeSH primário: |
Analgésicos/farmacologia Anti-Inflamatórios/farmacologia Antidiarreicos/farmacologia Depressores do Sistema Nervoso Central/farmacologia Extratos Vegetais/farmacologia
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[Mh] Termos MeSH secundário: |
Analgésicos/química Animais Anti-Inflamatórios/química Antidiarreicos/química Artemia/efeitos dos fármacos Comportamento Animal/efeitos dos fármacos Depressores do Sistema Nervoso Central/química Diarreia Masculino Camundongos Manejo da Dor Extratos Vegetais/química
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[Pt] Tipo de publicação: | JOURNAL ARTICLE |
[Nm] Nome de substância:
| 0 (Analgesics); 0 (Anti-Inflammatory Agents); 0 (Antidiarrheals); 0 (Central Nervous System Depressants); 0 (Plant Extracts) |
[Em] Mês de entrada: | 1803 |
[Cu] Atualização por classe: | 180305 |
[Lr] Data última revisão:
| 180305 |
[Sb] Subgrupo de revista: | IM |
[Da] Data de entrada para processamento: | 180131 |
[St] Status: | MEDLINE |
[do] DOI: | 10.1186/s12906-018-2100-5 |
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