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  1 / 1353 MEDLINE  
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[PMID]:29246832
[Au] Autor:Marques T; Silva GC; Henrique Paiva PM; Nascentes GAN; Ramirez LE; Norris K; Meira WSF
[Ad] Endereço:Programa de Pós-graduação em Medicina Tropical e Infectologia, Universidade Federal do Triângulo Mineiro, Uberaba, MG, Brazil.
[Ti] Título:Use of Tc-rCRP as a target for lytic antibody titration after experimental Trypanosoma cruzi infection.
[So] Source:Exp Parasitol;184:103-108, 2018 Jan.
[Is] ISSN:1090-2449
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Experimental Chagas disease has been used as a model to identify several host/parasite interaction factors involved in immune responses to Trypanosoma cruzi infection. One of the factors inherent to this parasite is the complement regulatory protein (Tc-CRP), a major epitope that induces production of lytic antibodies during T. cruzi infections. Previous studies have evaluated the function of Tc-CRP as an antigenic marker via ELISAs, which demonstrated high sensitivity and specificity when compared to other methods. Therefore, this study aimed to assess and compare the levels of lytic antibodies induced by this protein following experimental infection using different T. cruzi strains. Our results demonstrated that infections induced by strains isolated from vectors resulted in subpatent parasitaemia and low reactivity, as assessed by Tc-rCRP ELISAs. On the other hand, mice inoculated with T. cruzi strains isolated from patients developed patent parasitaemia, and presented elevated lytic antibodies titres, as measured by Tc-rCRP ELISA. In addition, comparison between different mouse lineages demonstrated that Balb/c mice were more reactive than C57BL/6 mice in almost all types of infections, except those infected by the AQ-4 strain. Parasites from the Hel strain generated the greatest lytic antibody response in all evaluated models. Therefore, application of sensitive techniques for monitoring immune responses would enable us to establish growth curves for lytic antibodies during the course of the infection, and allow us to discriminate between T. cruzi strains that originate from different hosts.
[Mh] Termos MeSH primário: Anticorpos Antiprotozoários/análise
Antígenos de Protozoários/imunologia
Doença de Chagas/imunologia
Proteínas de Protozoários/imunologia
Trypanosoma cruzi/imunologia
[Mh] Termos MeSH secundário: Animais
Biomarcadores/análise
Ensaio de Imunoadsorção Enzimática
Epitopos/imunologia
Interações Hospedeiro-Parasita/imunologia
Seres Humanos
Insetos Vetores/parasitologia
Masculino
Camundongos
Camundongos Endogâmicos BALB C
Camundongos Endogâmicos C57BL
Parasitemia/imunologia
Parasitemia/parasitologia
Sensibilidade e Especificidade
Triatominae/parasitologia
Trypanosoma cruzi/classificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Protozoan); 0 (Antigens, Protozoan); 0 (Biomarkers); 0 (Epitopes); 0 (Protozoan Proteins)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180205
[Lr] Data última revisão:
180205
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171217
[St] Status:MEDLINE


  2 / 1353 MEDLINE  
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Coura, José Rodrigues
Texto completo SciELO Brasil
[PMID]:29211104
[Au] Autor:Coura JR; Junqueira AC; Ferreira JMB
[Ad] Endereço:Fundação Oswaldo Cruz-Fiocruz, Instituto Oswaldo Cruz, Laboratório de Doenças Parasitárias, Rio de Janeiro, RJ, Brasil.
[Ti] Título:Surveillance of seroepidemiology and morbidity of Chagas disease in the Negro River, Brazilian Amazon.
[So] Source:Mem Inst Oswaldo Cruz;113(1):17-23, 2018 Jan.
[Is] ISSN:1678-8060
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Chagas disease in the Brazilian Amazon Region was previously regarded as an enzootic disease of wild animals. More recently, in situations where humans have penetrated the wild ecotope or where triatomines and/or wild animals (marsupials) have invaded human homes resulting in disease transmission, Chagas disease has come to be regarded as an anthropozoonosis. We found that the highest incidence of infection due to Trypanosoma cruzi and Chagas disease occurred among piassaba fibre gatherers and their families. OBJECTIVES: Considering the results of previous surveys, we conducted a new survey of piassaba gatherers and their families in the creeks of the Aracá, Curuduri, Demini, Ererê and Padauiri rivers, which are tributaries on the left bank of the Negro River, in the municipality of Barcelos; Barcelos-Caurés highway; Negro River in Santa Isabel of the Negro River; and Marié River, on the right bank of the Negro River. METHODS: A questionnaire was applied to 482 piassaba gatherers and their families who accompanied them. We collected 5-mL blood samples (with permission from each subject), separated the serum, and performed serological tests using indirect immunofluorescence and conventional and recombinant enzyme-linked immunosorbent assays (ELISA). We performed brief clinical examination and electrocardiograms. Only 273 subjects attended our field base for detailed clinical examination and electrocardiogram. FINDINGS AND MAIN CONCLUSIONS: The questionnaire revealed that 100% of the 482 patients recognised the triatomine Rhodnius brethesi, which they had seen in the piassaba plantation and 81% in their field huts. A total of 79% of subjects had previously been bitten by this vector and 21% did not know. The 25 subjects seropositive for T. cruzi infection (5.2%) stated that they had been bitten more than 10 times by this insect. Of the 273 subjects who underwent electrocardiogram, 22% showed conditions that were possibly attributable to Chagas disease or other cardiovascular disease.
[Mh] Termos MeSH primário: Doença de Chagas/epidemiologia
Insetos Vetores/classificação
Triatominae/classificação
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Animais
Anticorpos Antiprotozoários/sangue
Brasil/epidemiologia
Doença de Chagas/diagnóstico
Ensaio de Imunoadsorção Enzimática
Feminino
Seres Humanos
Insetos Vetores/parasitologia
Masculino
Meia-Idade
Vigilância da População
Estudos Soroepidemiológicos
Inquéritos e Questionários
Triatominae/parasitologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Protozoan)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180131
[Lr] Data última revisão:
180131
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171207
[St] Status:MEDLINE


  3 / 1353 MEDLINE  
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[PMID]:29232402
[Au] Autor:Keller JI; Ballif BA; St Clair RM; Vincent JJ; Monroy MC; Stevens L
[Ad] Endereço:Department of Biology, University of Vermont, Burlington, Vermont, United States of America.
[Ti] Título:Chagas disease vector blood meal sources identified by protein mass spectrometry.
[So] Source:PLoS One;12(12):e0189647, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Chagas disease is a complex vector borne parasitic disease involving blood feeding Triatominae (Hemiptera: Reduviidae) insects, also known as kissing bugs, and the vertebrates they feed on. This disease has tremendous impacts on millions of people and is a global health problem. The etiological agent of Chagas disease, Trypanosoma cruzi (Kinetoplastea: Trypanosomatida: Trypanosomatidae), is deposited on the mammalian host in the insect's feces during a blood meal, and enters the host's blood stream through mucous membranes or a break in the skin. Identifying the blood meal sources of triatomine vectors is critical in understanding Chagas disease transmission dynamics, can lead to identification of other vertebrates important in the transmission cycle, and aids management decisions. The latter is particularly important as there is little in the way of effective therapeutics for Chagas disease. Several techniques, mostly DNA-based, are available for blood meal identification. However, further methods are needed, particularly when sample conditions lead to low-quality DNA or to assess the risk of human cross-contamination. We demonstrate a proteomics-based approach, using liquid chromatography tandem mass spectrometry (LC-MS/MS) to identify host-specific hemoglobin peptides for blood meal identification in mouse blood control samples and apply LC-MS/MS for the first time to Triatoma dimidiata insect vectors, tracing blood sources to species. In contrast to most proteins, hemoglobin, stabilized by iron, is incredibly stable even being preserved through geologic time. We compared blood stored with and without an anticoagulant and examined field-collected insect specimens stored in suboptimal conditions such as at room temperature for long periods of time. To our knowledge, this is the first study using LC-MS/MS on field-collected arthropod disease vectors to identify blood meal composition, and where blood meal identification was confirmed with more traditional DNA-based methods. We also demonstrate the potential of synthetic peptide standards to estimate relative amounts of hemoglobin acquired when insects feed on multiple blood sources. These LC-MS/MS methods can contribute to developing Ecohealth control strategies for Chagas disease transmission and can be applied to other arthropod disease vectors.
[Mh] Termos MeSH primário: Doença de Chagas/parasitologia
Proteínas na Dieta/administração & dosagem
Espectrometria de Massas em Tandem/métodos
Triatominae/fisiologia
[Mh] Termos MeSH secundário: Animais
Cromatografia Líquida
Eletroforese em Gel de Poliacrilamida
Seres Humanos
Camundongos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Dietary Proteins)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180104
[Lr] Data última revisão:
180104
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171213
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189647


  4 / 1353 MEDLINE  
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Texto completo SciELO Brasil
[PMID]:28953999
[Au] Autor:Montenegro D; Cunha APD; Ladeia-Andrade S; Vera M; Pedroso M; Junqueira A
[Ad] Endereço:Fundação Oswaldo Cruz-Fiocruz, Instituto Oswaldo Cruz, Laboratório de Doenças Parasitárias, Rio de Janeiro, RJ, Brasil.
[Ti] Título:Multi-criteria decision analysis and spatial statistic: an approach to determining human vulnerability to vector transmission of Trypanosoma cruzi.
[So] Source:Mem Inst Oswaldo Cruz;112(10):709-718, 2017 Oct.
[Is] ISSN:1678-8060
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Chagas disease (CD), caused by the protozoan Trypanosoma cruzi, is a neglected human disease. It is endemic to the Americas and is estimated to have an economic impact, including lost productivity and disability, of 7 billion dollars per year on average. OBJECTIVES: To assess vulnerability to vector-borne transmission of T. cruzi in domiciliary environments within an area undergoing domiciliary vector interruption of T. cruzi in Colombia. METHODS: Multi-criteria decision analysis [preference ranking method for enrichment evaluation (PROMETHEE) and geometrical analysis for interactive assistance (GAIA) methods] and spatial statistics were performed on data from a socio-environmental questionnaire and an entomological survey. In the construction of multi-criteria descriptors, decision-making processes and indicators of five determinants of the CD vector pathway were summarily defined, including: (1) house indicator (HI); (2) triatominae indicator (TI); (3) host/reservoir indicator (Ho/RoI); (4) ecotope indicator (EI); and (5) socio-cultural indicator (S-CI). FINDINGS: Determination of vulnerability to CD is mostly influenced by TI, with 44.96% of the total weight in the model, while the lowest contribution was from S-CI, with 7.15%. The five indicators comprise 17 indices, and include 78 of the original 104 priority criteria and variables. The PROMETHEE and GAIA methods proved very efficient for prioritisation and quantitative categorisation of socio-environmental determinants and for better determining which criteria should be considered for interrupting the man-T. cruzi-vector relationship in endemic areas of the Americas. Through the analysis of spatial autocorrelation it is clear that there is a spatial dependence in establishing categories of vulnerability, therefore, the effect of neighbors' setting (border areas) on local values should be incorporated into disease management for establishing programs of surveillance and control of CD via vector. CONCLUSIONS: The study model proposed here is flexible and can be adapted to various eco-epidemiological profiles and is suitable for focusing anti-T. cruzi serological surveillance programs in vulnerable human populations.
[Mh] Termos MeSH primário: Doença de Chagas/transmissão
Técnicas de Apoio para a Decisão
Insetos Vetores
Triatominae/parasitologia
Trypanosoma cruzi
[Mh] Termos MeSH secundário: Animais
Seres Humanos
Análise Espacial
Populações Vulneráveis
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171109
[Lr] Data última revisão:
171109
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170928
[St] Status:MEDLINE


  5 / 1353 MEDLINE  
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[PMID]:28854191
[Au] Autor:Miño CI; de Souza ED; Moralez-Silva E; Valdes TA; Cortiço Corrêa Rodrigues VL; Del Lama SN
[Ad] Endereço:Instituto de Biología Subtropical (IBS), Nodo Iguazú, Universidad Nacional de Misiones (UNaM)-CONICET, Puerto Iguazú, Misiones, Argentina.
[Ti] Título:Use of noninvasive 'bug-eggs' to enable comparative inferences on genetic mating system with and without parental information: A study in a cattle egret colony.
[So] Source:PLoS One;12(8):e0183153, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Colonial waterbirds such as herons, egrets and spoonbills exhibit ecological characteristics that could have promoted the evolution of conspecific brood parasitism and extra-pair copulation. However, an adequate characterization of the genetic mating systems of this avian group has been hindered by the lack of samples of elusive candidate parents which precluded conducting conventional parentage allocation tests. Here, we investigate the genetic mating system of the invasive cattle egret using hematophagous insects contained in fake eggs to collect blood from incubating adults in a wild breeding colony. We tested a protocol with a previously unused Neotropical Triatominae, Panstrongylus megistus, obtained blood samples from males and females in 31 nests built on trees, drew blood from 89 nestlings at those nests, and genotyped all samples at 14 microsatellite loci, including six new species-specific loci. We comparatively addressed the performance of parentage allocation versus kinship classification of nestlings to infer the genetic mating system of cattle egrets. In line with previous behavioral observations, we found evidence in support of a non-monogamous genetic mating system, including extra-pair paternity (EPP) and conspecific brood parasitism (CBP). Parentage allocation tests detected a higher percentage of nests with alternative reproductive tactics (EPP: 61.7%; CBP: 64.5%) than the kinship classification method (EPP: 50.0%; CBP: 43.3%). Overall, these results indicate that rates of alternative reproductive tactics inferred in the absence of parental genetic information could be underestimated and should be interpreted with caution. This study highlights the importance of incorporating samples from candidate parents to adequately determine the genetic mating system of a species. We expand knowledge on the reproductive tactics of colonial waterbirds, contributing novel data on the genetic mating system of the cattle egret, valuable for the design of management strategies for this invasive bird.
[Mh] Termos MeSH primário: Aves/fisiologia
Copulação/fisiologia
Genótipo
Padrões de Herança
Preferência de Acasalamento Animal/fisiologia
Reprodução/genética
[Mh] Termos MeSH secundário: Animais
Brasil
Impressões Digitais de DNA/métodos
Feminino
Técnicas de Genotipagem
Espécies Introduzidas
Masculino
Repetições de Microssatélites
Comportamento de Nidação/fisiologia
Triatominae/química
Triatominae/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170831
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0183153


  6 / 1353 MEDLINE  
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[PMID]:28787451
[Au] Autor:Meyers AC; Meinders M; Hamer SA
[Ad] Endereço:Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, Texas, United States of America.
[Ti] Título:Widespread Trypanosoma cruzi infection in government working dogs along the Texas-Mexico border: Discordant serology, parasite genotyping and associated vectors.
[So] Source:PLoS Negl Trop Dis;11(8):e0005819, 2017 Aug.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Chagas disease, caused by the vector-borne protozoan Trypanosoma cruzi, is increasingly recognized in the southern U.S. Government-owned working dogs along the Texas-Mexico border could be at heightened risk due to prolonged exposure outdoors in habitats with high densities of vectors. We quantified working dog exposure to T. cruzi, characterized parasite strains, and analyzed associated triatomine vectors along the Texas-Mexico border. METHODOLOGY/PRINCIPLE FINDINGS: In 2015-2016, we sampled government working dogs in five management areas plus a training center in Texas and collected triatomine vectors from canine environments. Canine serum was tested for anti-T. cruzi antibodies with up to three serological tests including two immunochromatographic assays (Stat-Pak and Trypanosoma Detect) and indirect fluorescent antibody (IFA) test. The buffy coat fraction of blood and vector hindguts were tested for T. cruzi DNA and parasite discrete typing unit was determined. Overall seroprevalence was 7.4 and 18.9% (n = 528) in a conservative versus inclusive analysis, respectively, based on classifying weakly reactive samples as negative versus positive. Canines in two western management areas had 2.6-2.8 (95% CI: 1.0-6.8 p = 0.02-0.04) times greater odds of seropositivity compared to the training center. Parasite DNA was detected in three dogs (0.6%), including TcI and TcI/TcIV mix. Nine of 20 (45%) T. gerstaeckeri and T. rubida were infected with TcI and TcIV; insects analyzed for bloodmeals (n = 11) fed primarily on canine (54.5%). CONCLUSIONS/SIGNIFICANCE: Government working dogs have widespread exposure to T. cruzi across the Texas-Mexico border. Interpretation of sample serostatus was challenged by discordant results across testing platforms and very faint serological bands. In the absence of gold standard methodologies, epidemiological studies will benefit from presenting a range of results based on different tests/interpretation criteria to encompass uncertainty. Working dogs are highly trained in security functions and potential loss of duty from the clinical outcomes of infection could affect the work force and have broad consequences.
[Mh] Termos MeSH primário: Doença de Chagas/veterinária
Doenças do Cão/epidemiologia
Doenças do Cão/parasitologia
Insetos Vetores/parasitologia
Triatominae/parasitologia
Trypanosoma cruzi/classificação
Trypanosoma cruzi/isolamento & purificação
[Mh] Termos MeSH secundário: Animais
Anticorpos Antiprotozoários/sangue
Doença de Chagas/epidemiologia
Doença de Chagas/parasitologia
DNA de Protozoário/genética
DNA de Protozoário/isolamento & purificação
Cães
Técnica Indireta de Fluorescência para Anticorpo
Técnicas de Genotipagem
Imunocromatografia
Estudos Soroepidemiológicos
Texas/epidemiologia
Trypanosoma cruzi/genética
Trypanosoma cruzi/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Protozoan); 0 (DNA, Protozoan)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170901
[Lr] Data última revisão:
170901
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170809
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0005819


  7 / 1353 MEDLINE  
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[PMID]:28722578
[Au] Autor:de Oliveira J; Ravazi A; Souza EDS; Moreira FFF; Galvão C; da Rosa JA; Alevi KCC
[Ad] Endereço:Laboratório de Parasitologia, Departamento de Ciências Biológicas, Faculdade de Ciências Farmacêuticas, Universidade Estadual Paulista "Júlio de Mesquita Filho" (FCFAR/UNESP), Araraquara, Brazil.
[Ti] Título:Study of the Salivary Glands in Triatominae (Hemiptera, Reduviidae, Triatominae): Their Color and Application to the Chagas Disease Vector Evolution.
[So] Source:Am J Trop Med Hyg;97(3):771-773, 2017 Sep.
[Is] ISSN:1476-1645
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Chagas disease is caused by and transmitted by feces of a triatomine that has the habit of defecating during blood feeding. The salivary glands of triatomines are important to hematophagy because their saliva is rich in anticoagulant and hemolytic proteins. The salivary glands of some species analyzed are reddish due to the presence of nitrophorins (antihemostatic activity). The present study aimed to analyze the color pattern of the salivary glands of 67 triatomine species to evaluate whether the presence of nitrophorins is a synapomorphy of or the tribe Rhodniini, or if it is shared with triatomines of the tribes Triatomini and Cavernicolini. Since only the species of the tribe Rhoniini present red glands, it is admitted that the presence of nitrophorin proteins is a synapomorphy of the tribe Rhodniini and that this tribe has derived more recently when compared with Triatomini and Cavernicolini.
[Mh] Termos MeSH primário: Evolução Biológica
Doença de Chagas/transmissão
Glândulas Salivares/anatomia & histologia
Glândulas Salivares/fisiologia
Triatominae/anatomia & histologia
Triatominae/fisiologia
[Mh] Termos MeSH secundário: Animais
Feminino
Insetos Vetores/anatomia & histologia
Insetos Vetores/genética
Insetos Vetores/parasitologia
Insetos Vetores/fisiologia
Masculino
Pigmentos Biológicos
Especificidade da Espécie
Triatominae/genética
Triatominae/parasitologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Pigments, Biological)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171018
[Lr] Data última revisão:
171018
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170720
[St] Status:MEDLINE
[do] DOI:10.4269/ajtmh.16-0814


  8 / 1353 MEDLINE  
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[PMID]:28522273
[Au] Autor:Rives-Blanchard N; Torres-Pérez F; Ortiz S; Solari A; Campos-Soto R
[Ad] Endereço:Facultad de Ciencias Veterinarias y Pecuarias, Universidad de Chile, Santiago, Chile.
[Ti] Título:Trypanosoma cruzi over the ocean: Insular zones of Chile with presence of infected vector Mepraia species.
[So] Source:Acta Trop;172:229-231, 2017 Aug.
[Is] ISSN:1873-6254
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Chagas disease is one of the main zoonosis mediated by vectors in America. The etiologic agent Trypanosoma cruzi infects different mammals and is transmitted principally by the subfamily Triatominae. Mepraia is a genus endemic to Chile, responsible for transmitting T. cruzi in the sylvatic cycle. Mepraia includes three species: M. gajardoi and M. parapatrica inhabit coastal areas, while M. spinolai inhabits coastal and interior valleys. Previous studies reported the occurrence of Mepraia in Pan de Azucar Island, currently classified as M. parapatrica, but T. cruzi has not been reported in these insects. It is suggested that this could be due to infrequent insect feeding on mammalian hosts. In order to detect T. cruzi in insects from coastal islands, specimens from Pan de Azucar and Santa Maria Islands were examined. A region of kDNA of T. cruzi was amplified by PCR and hybridization assays were performed for T. cruzi genotyping of insect feces. The presence of infected insect and mixed T. cruzi infections was demonstrated. This is the first report of infected Triatominae in coastal islands in Chile. We discuss T. cruzi detection in insular zones, and the presumptive reservoirs that may participate in maintaining its transmission cycle in this habitat. Mixed and unidentified infections suggest that there are complex and unknown reservoir interactions in these habitats.
[Mh] Termos MeSH primário: Doença de Chagas/epidemiologia
Doença de Chagas/transmissão
Genótipo
Insetos Vetores/parasitologia
Triatominae/parasitologia
Trypanosoma cruzi/genética
[Mh] Termos MeSH secundário: Animais
Chile/epidemiologia
DNA de Cinetoplasto
Insetos Vetores/genética
Reação em Cadeia da Polimerase
Zoonoses/transmissão
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Kinetoplast)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171109
[Lr] Data última revisão:
171109
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170520
[St] Status:MEDLINE


  9 / 1353 MEDLINE  
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Texto completo SciELO Brasil
[PMID]:28443980
[Au] Autor:Russomando G; Cousiño B; Sanchez Z; Franco LX; Nara EM; Chena L; Martínez M; Galeano ME; Benitez L
[Ad] Endereço:Universidad Nacional de Asunción, Instituto de Investigaciones en Ciencias de la Salud, Laboratorio de Biología Molecular, Asunción, Paraguay.
[Ti] Título:Chagas disease: national survey of seroprevalence in children under five years of age conducted in 2008.
[So] Source:Mem Inst Oswaldo Cruz;112(5):348-353, 2017 May.
[Is] ISSN:1678-8060
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Since the early 1990s, programs to control Chagas disease in South America have focused on eradicating domiciliary Triatoma infestans, the main vector. Seroprevalence studies of the chagasic infection are included as part of the vector control programs; they are essential to assess the impact of vector control measures and to monitor the prevention of vector transmission. OBJECTIVE: To assess the interruption of domiciliary vector transmission of Chagas disease by T. infestans in Paraguay by evaluating the current state of transmission in rural areas. METHODS: A survey of seroprevalence of Chagas disease was carried out in a representative sample group of Paraguayans aged one to five years living in rural areas of Paraguay in 2008. Blood samples collected on filter paper from 12,776 children were tested using an enzyme-linked immunosorbent assay. Children whose serology was positive or undetermined (n = 41) were recalled to donate a whole blood sample for retesting. Their homes were inspected for current triatomine infestation. Blood samples from their respective mothers were also collected and tested to check possible transmission of the disease by a congenital route. FINDINGS: A seroprevalence rate of 0.24% for Trypanosoma cruzi infection was detected in children under five years of age among the country's rural population. Our findings indicate that T. cruzi was transmitted to these children vertically. The total number of infected children, aged one to five years living in these departments, was estimated at 1,691 cases with an annual incidence of congenital transmission of 338 cases per year. MAIN CONCLUSION: We determined the impact of vector control in the transmission of T. cruzi, following uninterrupted vector control measures employed since 1999 in contiguous T. infestans-endemic areas of Paraguay, and this allowed us to estimate the degree of risk of congenital transmission in the country.
[Mh] Termos MeSH primário: Doença de Chagas/epidemiologia
Inquéritos Epidemiológicos
Insetos Vetores/classificação
Triatominae/classificação
[Mh] Termos MeSH secundário: Animais
Doença de Chagas/prevenção & controle
Doença de Chagas/transmissão
Pré-Escolar
Ensaio de Imunoadsorção Enzimática
Seres Humanos
Lactente
Paraguai/epidemiologia
Prevalência
População Rural
Estudos Soroepidemiológicos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170824
[Lr] Data última revisão:
170824
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170427
[St] Status:MEDLINE


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[PMID]:28418113
[Au] Autor:Harris N; Woc-Colburn L; Gunter SM; Gorchakov R; Murray KO; Rossmann S; Garcia MN
[Ad] Endereço:Baylor College of Medicine, Michael E. Debakey Veterans Affairs Medical Center, Houston, TX, USA.
[Ti] Título:Autochthonous Chagas disease in the southern United States: A case report of suspected residential and military exposures.
[So] Source:Zoonoses Public Health;64(6):491-493, 2017 Sep.
[Is] ISSN:1863-2378
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Chagas disease is a parasitic infection that can result in a progressive dilated cardiomyopathy. Here, we present the epidemiologic details of a suspected locally acquired transmission case originating from the southern United States. This is the first published report of Chagas disease in a young, healthy United States veteran with repeat triatomine exposures in Arizona. Military personnel and Arizona residents should be aware of their Chagas disease transmission risks.
[Mh] Termos MeSH primário: Doença de Chagas/diagnóstico
[Mh] Termos MeSH secundário: Adulto
Animais
Arizona/epidemiologia
Doença de Chagas/epidemiologia
Seres Humanos
Insetos Vetores
Masculino
Triatominae/fisiologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170419
[St] Status:MEDLINE
[do] DOI:10.1111/zph.12360



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