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  1 / 9002 MEDLINE  
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[PMID]:29030319
[Au] Autor:Dutta S; Celestine MJ; Khanal S; Huddleston A; Simms C; Arca JF; Mitra A; Heller L; Kraj PJ; Ledizet M; Anderson JF; Neelakanta G; Holder AA; Sultana H
[Ad] Endereço:Department of Biological Sciences, Old Dominion University, Norfolk, VA, USA.
[Ti] Título:Coordination of different ligands to copper(II) and cobalt(III) metal centers enhances Zika virus and dengue virus loads in both arthropod cells and human keratinocytes.
[So] Source:Biochim Biophys Acta;1862(1):40-50, 2018 01.
[Is] ISSN:0006-3002
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Trace elements such as copper and cobalt have been associated with virus-host interactions. However, studies to show the effect of conjugation of copper(II) or cobalt(III) metal centers to thiosemicarbazone ligand(s) derived from either food additives or mosquito repellent such as 2-acetylethiazole or citral, respectively, on Zika virus (ZIKV) or dengue virus (serotype 2; DENV2) infections have not been explored. In this study, we show that four compounds comprising of thiosemicarbazone ligand derived from 2-acetylethiazole viz., (E)-N-ethyl-2-[1-(thiazol-2-yl)ethylidene]hydrazinecarbothioamide (acetylethTSC) (compound 1), a copper(II) complex with acetylethTSC as a ligand (compound 2), a thiosemicarbazone ligand-derived from citral (compound 3) and a cobalt(III) complex with a citral-thiosemicarbazone ligand (compound 4) increased DENV2 and ZIKV replication in both mosquito C6/36 cells and human keratinocytes (HaCaT cells). Treatment of both cell lines with compounds 2 or 4 showed increased dengue viral titers at all three tested doses. Enhanced dengue viral plaque formation was also noted at the tested dose of 100µM, suggesting higher production of infectious viral particles. Treatment with the compounds 2 or 4 enhanced ZIKV and DENV2 RNA levels in HeLa cell line and primary cultures of mouse bone marrow derived dendritic cells. Also, pre- or post treatments with conjugated compounds 2 or 4 showed higher loads of ZIKV or DENV2 envelope (E) protein in HaCaT cells. No changes in loads of E-protein were found in ZIKV-infected C6/36 cells, when compounds were treated after infection. In addition, we tested bis(1,10-phenanthroline)copper(II) chloride ([Cu(phen) ]Cl , (compound 5) and tris(1,10-phenanthroline)cobalt(III) chloride ([Co(phen) ]Cl , (compound 6) that also showed enhanced DENV2 loads. Also, we found that copper(II) chloride dehydrate (CuCl ·2H O) or cobalt(II) chloride hexahydrate (CoCl ·6H O) alone had no effects as "free" cations. Taken together, these findings suggest that use of Cu(II) or Co(III) conjugation to organic compounds, in insect repellents and/or food additives could enhance DENV2/ZIKV loads in human cells and perhaps induce pathogenesis in infected individuals or individuals pre-exposed to such conjugated complexes. IMPORTANCE: Mosquito-borne diseases are of great concern to the mankind. Use of chemicals/repellents against mosquito bites and transmission of microbes has been the topic of interest for many years. Here, we show that thiosemicarbazone ligand(s) derived from 2-acetylethiazole or citral or 1,10-phenanthroline upon conjugation with copper(II) or cobalt(III) metal centers enhances dengue virus (serotype 2; DENV2) and/or Zika virus (ZIKV) infections in mosquito, mouse and human cells. Enhanced ZIKV/DENV2 capsid mRNA or envelope protein loads were evident in mosquito cells and human keratinocytes, when treated with compounds before/after infections. Also, treatment with copper(II) or cobalt(III) conjugated compounds increased viral titers and number of plaque formations. These studies suggest that conjugation of compounds in repellents/essential oils/natural products/food additives with copper(II) or cobalt(III) metal centers may not be safe, especially in tropical and subtropical places, where several dengue infection cases and deaths are reported annually or in places with increased ZIKV caused microcephaly.
[Mh] Termos MeSH primário: Cobalto
Complexos de Coordenação
Cobre
Vírus da Dengue/metabolismo
Queratinócitos/virologia
Carga Viral/efeitos dos fármacos
Zika virus/metabolismo
[Mh] Termos MeSH secundário: Animais
Cercopithecus aethiops
Cobalto/química
Cobalto/farmacologia
Complexos de Coordenação/química
Complexos de Coordenação/farmacologia
Cobre/química
Cobre/farmacologia
Culicidae
Células HeLa
Seres Humanos
Queratinócitos/metabolismo
Queratinócitos/patologia
Células Vero
Proteínas do Envelope Viral
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (Coordination Complexes); 0 (Viral Envelope Proteins); 3G0H8C9362 (Cobalt); 789U1901C5 (Copper)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171015
[St] Status:MEDLINE


  2 / 9002 MEDLINE  
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[PMID]:29304168
[Au] Autor:Mei T; Fu WB; Li B; He ZB; Chen B
[Ad] Endereço:Chongqing Key Laboratory of Vector Insects; Chongqing Key Laboratory of Animal Biology; Institute of Entomology and Molecular Biology, Chongqing Normal University, Chongqing, P.R. China.
[Ti] Título:Comparative genomics of chemosensory protein genes (CSPs) in twenty-two mosquito species (Diptera: Culicidae): Identification, characterization, and evolution.
[So] Source:PLoS One;13(1):e0190412, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Chemosensory proteins (CSP) are soluble carrier proteins that may function in odorant reception in insects. CSPs have not been thoroughly studied at whole-genome level, despite the availability of insect genomes. Here, we identified/reidentified 283 CSP genes in the genomes of 22 mosquitoes. All 283 CSP genes possess a highly conserved OS-D domain. We comprehensively analyzed these CSP genes and determined their conserved domains, structure, genomic distribution, phylogeny, and evolutionary patterns. We found an average of seven CSP genes in each of 19 Anopheles genomes, 27 CSP genes in Cx. quinquefasciatus, 43 in Ae. aegypti, and 83 in Ae. albopictus. The Anopheles CSP genes had a simple genomic organization with a relatively consistent gene distribution, while most of the Culicinae CSP genes were distributed in clusters on the scaffolds. Our phylogenetic analysis clustered the CSPs into two major groups: CSP1-8 and CSE1-3. The CSP1-8 groups were all monophyletic with good bootstrap support. The CSE1-3 groups were an expansion of the CSP family of genes specific to the three Culicinae species. The Ka/Ks ratios indicated that the CSP genes had been subject to purifying selection with relatively slow evolution. Our results provide a comprehensive framework for the study of the CSP gene family in these 22 mosquito species, laying a foundation for future work on CSP function in the detection of chemical cues in the surrounding environment.
[Mh] Termos MeSH primário: Culicidae/genética
Evolução Molecular
Receptores Odorantes/genética
[Mh] Termos MeSH secundário: Animais
Culicidae/classificação
Genoma de Inseto
Filogenia
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Receptors, Odorant)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180106
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190412


  3 / 9002 MEDLINE  
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[PMID]:28469032
[Au] Autor:Chotiwan N; Brewster CD; Magalhaes T; Weger-Lucarelli J; Duggal NK; Rückert C; Nguyen C; Garcia Luna SM; Fauver JR; Andre B; Gray M; Black WC; Kading RC; Ebel GD; Kuan G; Balmaseda A; Jaenisch T; Marques ETA; Brault AC; Harris E; Foy BD; Quackenbush SL; Perera R; Rovnak J
[Ad] Endereço:Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA.
[Ti] Título:Rapid and specific detection of Asian- and African-lineage Zika viruses.
[So] Source:Sci Transl Med;9(388), 2017 May 03.
[Is] ISSN:1946-6242
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Understanding the dynamics of Zika virus transmission and formulating rational strategies for its control require precise diagnostic tools that are also appropriate for resource-poor environments. We have developed a rapid and sensitive loop-mediated isothermal amplification (LAMP) assay that distinguishes Zika viruses of Asian and African lineages. The assay does not detect chikungunya virus or flaviviruses such as dengue, yellow fever, or West Nile viruses. The assay conditions allowed direct detection of Zika virus RNA in cultured infected cells; in mosquitoes; in virus-spiked samples of human blood, plasma, saliva, urine, and semen; and in infected patient serum, plasma, and semen samples without the need for RNA isolation or reverse transcription. The assay offers rapid, specific, sensitive, and inexpensive detection of the Asian-lineage Zika virus strain that is currently circulating in the Western hemisphere, and can also detect the African-lineage Zika virus strain using separate, specific primers.
[Mh] Termos MeSH primário: Técnicas de Amplificação de Ácido Nucleico/métodos
[Mh] Termos MeSH secundário: Animais
Culicidae
Seres Humanos
RNA Viral
Zika virus
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (RNA, Viral)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE


  4 / 9002 MEDLINE  
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[PMID]:27770704
[Au] Autor:Wichit S; Ferraris P; Choumet V; Missé D
[Ad] Endereço:Laboratory of MIVEGEC, UMR 224 IRD/CNRS/UM1, Montpellier, France.
[Ti] Título:The effects of mosquito saliva on dengue virus infectivity in humans.
[So] Source:Curr Opin Virol;21:139-145, 2016 12.
[Is] ISSN:1879-6265
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Arboviruses such as Dengue, Chikungunya, and Zika viruses represent a major public health problem due to globalization and propagation of susceptible vectors worldwide. Arthropod vector-derived salivary factors have the capacity to modulate human cells function by enhancing or suppressing viral replication and, therefore, modify the establishment of local and systemic viral infection. Here, we discuss how mosquito saliva may interfere with Dengue virus (DENV) infection in humans. Identification of saliva factors that enhance infectivity will allow the production of vector-based vaccines and therapeutics that would interfere with viral transmission by targeting arthropod saliva components. Understanding the role of salivary proteins in DENV transmission will provide tools to control not only Dengue but also other arboviral diseases transmitted by the same vectors.
[Mh] Termos MeSH primário: Culicidae/virologia
Vírus da Dengue/patogenicidade
Dengue/transmissão
Transmissão de Doença Infecciosa
Interações Hospedeiro-Patógeno
Saliva/metabolismo
[Mh] Termos MeSH secundário: Animais
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1710
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161023
[St] Status:MEDLINE


  5 / 9002 MEDLINE  
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[PMID]:29297702
[Au] Autor:Schultz MJ; Connor JH; Frydman HM
[Ad] Endereço:1 Department of Biology, Boston University , Boston Massachusetts.
[Ti] Título:Group B Wolbachia Strain-Dependent Inhibition of Arboviruses.
[So] Source:DNA Cell Biol;37(1):2-6, 2018 Jan.
[Is] ISSN:1557-7430
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Mosquito-borne viruses, including Zika virus (ZIKV) and dengue virus (DENV), are global threats that continue to infect millions annually. Historically, efforts to combat the spread of these diseases have sought to eradicate the mosquito population. This has had limited success. Recent efforts to combat the spread of these diseases have targeted the mosquito population and the mosquito's ability to transmit viruses by altering the mosquito's microbiome. The introduction of particular strains of Wolbachia bacteria into mosquitos suppresses viral growth and blocks disease transmission. This novel strategy is being tested worldwide to reduce DENV and has early indications of success. The Wolbachia genus comprised divergent strains that are divided in major phylogenetic clades termed supergroups. All Wolbachia field trials currently utilize supergroup A Wolbachia in Aedes aegypti mosquitos to limit virus transmission. Here we discuss our studies of Wolbachia strains not yet used in virus control strategies but that show strong potential to reduce ZIKV replication. These strains are important opportunities in the search for novel tools to reduce the levels of mosquito-borne viruses and provide additional models for mechanistic studies.
[Mh] Termos MeSH primário: Arbovirus/fisiologia
Wolbachia/virologia
[Mh] Termos MeSH secundário: Aedes/virologia
Animais
Culicidae/virologia
Vírus da Dengue/fisiologia
Filogenia
Replicação Viral/fisiologia
Zika virus/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180210
[Lr] Data última revisão:
180210
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180104
[St] Status:MEDLINE
[do] DOI:10.1089/dna.2017.4025


  6 / 9002 MEDLINE  
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[PMID]:28468299
[Au] Autor:Holbrook MR
[Ad] Endereço:NIAID Integrated Research Facility, 8200 Research Plaza, Ft. Detrick, Frederick, MD 21702, USA. Michael.holbrook@nih.gov.
[Ti] Título:Historical Perspectives on Flavivirus Research.
[So] Source:Viruses;9(5), 2017 04 30.
[Is] ISSN:1999-4915
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:The flaviviruses are small single-stranded RNA viruses that are typically transmitted by mosquito or tick vectors. These "arboviruses" are found around the world and account for a significant number of cases of human disease. The flaviviruses cause diseases ranging from mild or sub-clinical infections to lethal hemorrhagic fever or encephalitis. In many cases, survivors of neurologic flavivirus infections suffer long-term debilitating sequelae. Much like the emergence of West Nile virus in the United States in 1999, the recent emergence of Zika virus in the Americas has significantly increased the awareness of mosquito-borne viruses. The diseases caused by several flaviviruses have been recognized for decades, if not centuries. However, there is still a lot that is unknown about the flaviviruses as the recent experience with Zika virus has taught us. The objective of this review is to provide a general overview and some historical perspective on several flaviviruses that cause significant human disease. In addition, available medical countermeasures and significant gaps in our understanding of flavivirus biology are also discussed.
[Mh] Termos MeSH primário: Pesquisa Biomédica
Infecções por Flavivirus
Flavivirus
[Mh] Termos MeSH secundário: Animais
Pesquisa Biomédica/história
Culicidae/virologia
Dengue/epidemiologia
Dengue/história
Dengue/virologia
Vírus da Dengue
Flavivirus/fisiologia
Infecções por Flavivirus/epidemiologia
Infecções por Flavivirus/história
Infecções por Flavivirus/imunologia
Infecções por Flavivirus/virologia
História do Século XVIII
História do Século XIX
História do Século XX
Seres Humanos
Febre do Nilo Ocidental/epidemiologia
Febre do Nilo Ocidental/história
Febre do Nilo Ocidental/virologia
Vírus do Nilo Ocidental/fisiologia
Febre Amarela/história
Febre Amarela/virologia
Zika virus/fisiologia
[Pt] Tipo de publicação:HISTORICAL ARTICLE; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180208
[Lr] Data última revisão:
180208
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE


  7 / 9002 MEDLINE  
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[PMID]:28742952
[Au] Autor:Schwartz FW; Liu G; Aggarwal P; Schwartz CM
[Ad] Endereço:School of Earth Sciences, The Ohio State University, Columbus, OH, 43210.
[Ti] Título:Naïve Simplicity: The Overlooked Piece of the Complexity-Simplicity Paradigm.
[So] Source:Ground Water;55(5):703-711, 2017 09.
[Is] ISSN:1745-6584
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Concepts of simplicity and complexity in modeling have been explored in papers, editorials, and talks. The concept is not well understood because there are at least two flavors of simplicity. Modelers envision simplicity (i.e., elegant simplicity) as the sought-after goal in modeling, but naïve simplicity, which is the focus of this paper, is commonly unrecognized and dangerous. The problem is that naïve or simple ideas are often mistaken for settled science and come with the prospect of being more wrong than right. The concept of the so-called simplicity cycle, in relation to classical problems of carbon-14 age and salinity in closed-basin lakes, is used to illustrate these points. The emerging problems of water-mosquitoes-diseases show the value of mapping new problems to the simplicity cycle. Researchers can "know what they do not know" and avoid the dangers of naïve simplicity.
[Mh] Termos MeSH primário: Radioisótopos de Carbono
Lagos
[Mh] Termos MeSH secundário: Animais
Culicidae
Água Subterrânea
Insetos Vetores
Água
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (Carbon Radioisotopes); 059QF0KO0R (Water)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:180130
[Lr] Data última revisão:
180130
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170726
[St] Status:MEDLINE
[do] DOI:10.1111/gwat.12570


  8 / 9002 MEDLINE  
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[PMID]:29261762
[Au] Autor:Bennis I; Belaid L; De Brouwere V; Filali H; Sahibi H; Boelaert M
[Ad] Endereço:National School of Public Health-Ministry of Health, Rabat, Morocco.
[Ti] Título:"The mosquitoes that destroy your face". Social impact of Cutaneous Leishmaniasis in South-eastern Morocco, A qualitative study.
[So] Source:PLoS One;12(12):e0189906, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To document the psychosocial burden of Cutaneous Leishmaniasis (CL) in rural communities in Southeastern Morocco. METHOD: Between March and April 2015, we conducted qualitative research in communities exposed to Leishmania major or L. tropica in Errachidia and Tinghir provinces. Twenty-eight focus groups discussions (FGDs) were realized, with a stratification by gender and tradition of medicine (users of folk versus professional medicine). Data were analyzed using content analysis. RESULTS: This rural population most exposed to CL in Morocco lacks access to health care in general and clearly points out there are other major public health issues that need to be resolved. Nonetheless, respondents consider the impact of CL lesions and scars as important and similar to that of burn scar tissue. Young women with CL scars in the face are stigmatized and will often be rejected for marriage in these communities. People usually try a long list of folk remedies on the active lesions, but none was felt adequate. There was a clear demand for better treatment as well as for treatment of the scars. CONCLUSIONS: The psycho-social impact of CL due to L.major and L.tropica is substantial, especially for young single women with facial scars. These generate social and self-stigma and diminish their marriage prospects. CL is well known, but not considered as a major health priority by these poor rural communities in South-eastern Morocco where gender discrimination is still an issue and access to basic health care is as neglected as CL. Early CL diagnosis and new treatment options with better skin outcomes are urgently needed.
[Mh] Termos MeSH primário: Culicidae/fisiologia
Leishmaniose Cutânea/epidemiologia
Leishmaniose Cutânea/psicologia
Pesquisa Qualitativa
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Animais
Cicatriz/patologia
Feminino
Geografia
Conhecimentos, Atitudes e Prática em Saúde
Seres Humanos
Masculino
Meia-Idade
Marrocos/epidemiologia
Aceitação pelo Paciente de Cuidados de Saúde
Percepção
Sexismo
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171221
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189906


  9 / 9002 MEDLINE  
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[PMID]:29228413
[Au] Autor:Furuya H
[Ad] Endereço:Basic Clinical Science and Public Health, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1193, Japan. furuya@is.icc.u-tokai.ac.jp.
[Ti] Título:Estimating Vector-borne Viral Infections in the Urban Setting of the 2020 Tokyo Olympics, Japan, Using Mathematical Modeling.
[So] Source:Tokai J Exp Clin Med;42(4):160-164, 2017 Dec 20.
[Is] ISSN:2185-2243
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:The first domestic outbreak of dengue fever in Japan since 1945 was reported in Tokyo in 2014. Meanwhile, daily mean summer temperatures are expected to continue to rise world-wide. Such conditions are expected to increase the risk of an arbovirus outbreak at the 2020 Tokyo Olympic Games. To address this possibility, the present study compared estimates of the risk of infection by dengue, chikungunya, and Zika viruses in urban areas. To compare the risk of infection by arboviruses transmitted by Ae. albopictus mosquitoes, the reproduction number for each of three arboviruses was estimated under the environmental conditions associated with the 2014 dengue outbreak in Tokyo, and additionally under conditions assuming a daily mean temperature elevation of 2° C. For dengue, chikungunya, and Zika, the estimated distributions of R were independently fitted to gamma distributions yielding median R values of 1.00, 0.46, and 0.36, respectively. If the daily mean temperature were to rise from 28° C to 30° C, our model predicts increases of the median R of 18% for dengue, 4.3% for chikungunya, and 11.1% for Zika. Strengthening of the public health responsivity for these emerging arboviral diseases will be needed in preparation for the 2020 Olympic Games in Tokyo.
[Mh] Termos MeSH primário: Aniversários e Eventos Especiais
Infecções por Arbovirus/epidemiologia
Febre de Chikungunya/epidemiologia
Dengue/epidemiologia
Surtos de Doenças/estatística & dados numéricos
Modelos Teóricos
População Urbana/estatística & dados numéricos
Infecção pelo Zika virus/epidemiologia
[Mh] Termos MeSH secundário: Animais
Infecções por Arbovirus/prevenção & controle
Infecções por Arbovirus/transmissão
Febre de Chikungunya/prevenção & controle
Febre de Chikungunya/transmissão
Culicidae
Dengue/prevenção & controle
Dengue/transmissão
Surtos de Doenças/prevenção & controle
Vetores de Doenças
Previsões
Seres Humanos
Japão
Risco
Temperatura Ambiente
Tóquio
Infecção pelo Zika virus/prevenção & controle
Infecção pelo Zika virus/transmissão
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171212
[St] Status:MEDLINE


  10 / 9002 MEDLINE  
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[PMID]:27777104
[Au] Autor:Petric D; Petrovic T; Hrnjakovic Cvjetkovic I; Zgomba M; Milosevic V; Lazic G; Ignjatovic Cupina A; Lupulovic D; Lazic S; Dondur D; Vaselek S; Zivulj A; Kisin B; Molnar T; Janku D; Pudar D; Radovanov J; Kavran M; Kovacevic G; Plavsic B; Jovanovic Galovic A; Vidic M; Ilic S; Petric M
[Ad] Endereço:Faculty of Agriculture, University of Novi Sad, Trg Dositeja Obradovica 8, 21000, Novi Sad, Serbia. Electronic address: dusanp@polj.uns.ac.rs.
[Ti] Título:West Nile virus 'circulation' in Vojvodina, Serbia: Mosquito, bird, horse and human surveillance.
[So] Source:Mol Cell Probes;31:28-36, 2017 02.
[Is] ISSN:1096-1194
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Efforts to detect West Nile virus (WNV) in the Vojvodina province, northern Serbia, commenced with human and mosquito surveillance in 2005, followed by horse (2009) and wild bird (2012) surveillance. The knowledge obtained regarding WNV circulation, combined with the need for timely detection of virus activity and risk assessment resulted in the implementation of a national surveillance programme integrating mosquito, horse and bird surveillance in 2014. From 2013, the system showed highly satisfactory results in terms of area specificity (the capacity to indicate the spatial distribution of the risk for human cases of West Nile neuroinvasive disease - WNND) and sensitivity to detect virus circulation even at the enzootic level. A small number (n = 50) of Culex pipiens (pipiens and molestus biotypes, and their hybrids) females analysed per trap/night, combined with a high number of specimens in the sample, provided variable results in the early detection capacity at different administrative levels (NUTS2 versus NUTS3). The clustering of infected mosquitoes, horses, birds and human cases of WNND in 2014-2015 was highly significant, following the south-west to north-east direction in Vojvodina (NUTS2 administrative level). Human WNND cases grouped closest with infected mosquitoes in 2014, and with wild birds/mosquitoes in 2015. In 2014, sentinel horses showed better spatial correspondence with human WNND cases than sentinel chickens. Strong correlations were observed between the vector index values and the incidence of human WNND cases recorded at the NUTS2 and NUTS3 levels. From 2010, West Nile virus was detected in mosquitoes sampled at 43 different trap stations across Vojvodina. At 14 stations (32.56%), WNV was detected in two different (consecutive or alternate) years, at 2 stations in 3 different years, and in 1 station during 5 different years. Based on these results, integrated surveillance will be progressively improved to allow evidence-based adoption of preventive public health and mosquito control measures.
[Mh] Termos MeSH primário: Aves/virologia
Culicidae/virologia
Cavalos/virologia
Vigilância da População
Febre do Nilo Ocidental/epidemiologia
Febre do Nilo Ocidental/virologia
Vírus do Nilo Ocidental/fisiologia
[Mh] Termos MeSH secundário: Animais
Geografia
Seres Humanos
Estações do Ano
Sérvia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1711
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161030
[St] Status:MEDLINE



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