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[PMID]:28395752
[Au] Autor:Vatta AF; Everett WR; Holzmer SJ; Cherni JA; King VL; Rugg D; Geurden T
[Ad] Endereço:Zoetis, Veterinary Medicine Research and Development, 333 Portage Street, Kalamazoo, MI 49007, USA. Electronic address: adriano.vatta@zoetis.com.
[Ti] Título:Efficacy of a new spot-on formulation of selamectin plus sarolaner for cats against adult Ctenocephalides felis, flea egg production and adult flea emergence.
[So] Source:Vet Parasitol;238 Suppl 1:S22-S26, 2017 Apr.
[Is] ISSN:1873-2550
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:A new spot-on formulation of selamectin plus sarolaner was evaluated against fleas for adulticidal efficacy, and for the effect on egg production and hatching when applied to flea-infested cats. Ten male and ten female adult domestic shorthair cats were randomly assigned to one of two treatment groups based on pre-treatment flea counts. Cats received topical treatment on Day 0 in a single spot to the dorsal scapular area with either a placebo formulation or with the combination formulation at the minimal dose of 6.0mg selamectin plus 1.0mg sarolaner per kg bodyweight. On Days -1, 5, 12, 19, 26 and 33, cats were infested with approximately 100 (±5) unfed Ctenocephalides felis fleas. At 24h after treatment or 48h after subsequent flea infestation, cats were housed for a 20-h period in a cage to allow collection of flea eggs. At the end of this period, flea eggs were collected from the cages and cats were combed to remove and count live fleas. Emerged viable larvae and emerged adult fleas were counted 3days and 35days, respectively, after egg collection. The new spot-on formulation of selamectin plus sarolaner provided 100% efficacy against adult fleas up to Day 36 following a single application. Fleas on placebo-treated cats produced large numbers of eggs throughout the study, with individual counts ranging from 110 to 1256 eggs. Following treatment, four flea eggs were collected from a single selamectin/sarolaner-treated cat on Day 29, but there were no eggs collected from any other selamectin/sarolaner-treated animal during the study. No larvae or adult fleas developed from these four eggs. From the eggs collected from the placebo-treated cats, the mean percentage of live larvae and adults that emerged ranged from 67.3% to 84.2% and from 50.7% to 81.8%, respectively. A single topical treatment with a new spot-on formulation of selamectin plus sarolaner at the minimum label dose thus controlled fleas on cats and was 100% effective in preventing flea reproduction for over one month after treatment.
[Mh] Termos MeSH primário: Doenças do Gato/tratamento farmacológico
Ctenocephalides/efeitos dos fármacos
Infestações por Pulgas/tratamento farmacológico
Isoxazóis/administração & dosagem
Isoxazóis/farmacologia
Ivermectina/análogos & derivados
[Mh] Termos MeSH secundário: Administração Tópica
Animais
Antiparasitários/administração & dosagem
Antiparasitários/farmacologia
Gatos
Feminino
Infestações por Pulgas/veterinária
Ivermectina/administração & dosagem
Ivermectina/farmacologia
Masculino
Distribuição Aleatória
Reprodução/efeitos dos fármacos
Resultado do Tratamento
Zigoto/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antiparasitic Agents); 0 (Isoxazoles); 70288-86-7 (Ivermectin); A2669OWX9N (selamectin)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170418
[Lr] Data última revisão:
170418
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170412
[St] Status:MEDLINE


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[PMID]:28115179
[Au] Autor:Chandra S; Forsyth M; Lawrence AL; Emery D; Slapeta J
[Ad] Endereço:School of Life and Environmental Sciences, Faculty of Veterinary Science, University of Sydney, NSW, Australia.
[Ti] Título:Cat fleas (Ctenocephalides felis) from cats and dogs in New Zealand: Molecular characterisation, presence of Rickettsia felis and Bartonella clarridgeiae and comparison with Australia.
[So] Source:Vet Parasitol;234:25-30, 2017 Jan 30.
[Is] ISSN:1873-2550
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The cat flea (Ctenocephalides felis) is the most common flea species parasitising both domestic cats and dogs globally. Fleas are known vectors of zoonotic pathogens such as vector borne Rickettsia and Bartonella. This study compared cat fleas from domestic cats and dogs in New Zealand's North and South Islands to Australian cat fleas, using the mitochondrial DNA (mtDNA) marker, cytochrome c oxidase subunit I and II (cox1, cox2). We assessed the prevalence of Rickettsia and Bartonella using genus specific multiplexed real-time PCR assays. Morphological identification confirmed that the cat flea (C. felis) is the most common flea in New Zealand. The examined fleas (n=43) at cox1 locus revealed six closely related C. felis haplotypes (inter-haplotype distance 1.1%) across New Zealand. The New Zealand C. felis haplotypes were identical or near identical with haplotypes from southern Australia demonstrating common dispersal of haplotype lineage across both the geographical (Tasman Sea) and climate scale. New Zealand cat fleas carried Rickettsia felis (5.3%) and Bartonella clarridgeiae (18.4%). To understand the capability of C. felis to vector zoonotic pathogens, we determined flea cox1 and cox2 haplotype diversity with the tandem multiplexed real-time PCR and sequencing for Bartonella and Rickettsia. This enabled us to demonstrate highly similar cat fleas on cat and dog populations across Australia and New Zealand.
[Mh] Termos MeSH primário: Bartonella/fisiologia
Gatos/parasitologia
Ctenocephalides/microbiologia
Cães/parasitologia
Rickettsia felis/fisiologia
[Mh] Termos MeSH secundário: Animais
Austrália
Proteínas de Bactérias/genética
Bartonella/genética
Gatos/microbiologia
Cães/microbiologia
Complexo IV da Cadeia de Transporte de Elétrons/genética
Variação Genética
Haplótipos
Insetos Vetores/microbiologia
Nova Zelândia
Rickettsia felis/genética
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bacterial Proteins); EC 1.9.3.1 (Electron Transport Complex IV)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170203
[Lr] Data última revisão:
170203
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170125
[St] Status:MEDLINE


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[PMID]:28082625
[Au] Autor:Billeter SA; Metzger ME
[Ad] Endereço:California Department of Public Health, Vector-Borne Disease Section, Ontario, CA 91764 (sarah.billeter@cdph.ca.gov; marco.metzger@cdph.ca.gov) sarah.billeter@cdph.ca.gov.
[Ti] Título:Limited Evidence for Rickettsia felis as a Cause of Zoonotic Flea-Borne Rickettsiosis in Southern California.
[So] Source:J Med Entomol;54(1):4-7, 2017 Jan.
[Is] ISSN:1938-2928
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Over 90% of human flea-borne rickettsioses cases in California are reported from suburban communities of Los Angeles and Orange counties and are presumed to be associated with either Rickettsia typhi or Rickettsia felis infection. Ctenocephalides felis (Bouché) is considered the principal vector for both rickettsiae, and R. felis has largely replaced R. typhi as the presumptive etiologic agent based on the widespread incidence of R. felis in cat flea populations. However, with no evidence to confirm R. felis as the cause of human illness in southern California, coupled with recent findings that showed R. felis to be widespread in cat fleas statewide, we propose that this hypothesis should be reconsidered. Evidence of only limited numbers of R. typhi-infected cat fleas in the environment may indicate a very rare infection and explain why so few cases of flea-borne rickettsioses are reported each year in southern California relative to the population.
[Mh] Termos MeSH primário: Doenças do Gato/epidemiologia
Ctenocephalides/microbiologia
Insetos Vetores/microbiologia
Infecções por Rickettsia/veterinária
Rickettsia felis/isolamento & purificação
Rickettsia typhi/isolamento & purificação
[Mh] Termos MeSH secundário: Animais
California
Doenças do Gato/parasitologia
Gatos
Seres Humanos
Los Angeles
Infecções por Rickettsia/epidemiologia
Infecções por Rickettsia/parasitologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170823
[Lr] Data última revisão:
170823
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170114
[St] Status:MEDLINE
[do] DOI:10.1093/jme/tjw179


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[PMID]:28073394
[Au] Autor:Alarcón ME; Jara-F A; Briones RC; Dubey AK; Slamovits CH
[Ad] Endereço:Liceo Alemán del Verbo Divino Lynch 350 Los Ángeles,Bío-Bío,Chile.
[Ti] Título:Gregarine infection accelerates larval development of the cat flea Ctenocephalides felis (Bouché).
[So] Source:Parasitology;144(4):419-425, 2017 Apr.
[Is] ISSN:1469-8161
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A high degree of specialization between host and parasite is a well-known outcome of a long history of coevolution, and it is strikingly illustrated in a coordination of their life cycles. In some cases, the arms race ensued at the establishment of a symbiotic relationship results in the adoption of manipulative strategies by the parasite. We have already learned that Steinina ctenocephali, a gregarine living in the alimentary canal of cat flea, Ctenocephalides felis follows its phenology and metamorphosis. Despite these findings the outcome of their symbiotic partnership (mutualist, parasitic or commensal) remains unclear. To address this important question, we measured life history parameters of the flea in the presence of varying infection intensities of gregarine oocysts in laboratory conditions. We found that neither the emergence nor survival rate of fleas was affected by harbouring the gregarines. More surprisingly, our results show that flea larvae infected with gregarines developed faster and emerged earlier than the control group. This gregarine therefore joins the selected group of protists that can modify physiological host traits and provides not only new model taxa to be explored in an evolutionary scenario, but also potential development of control strategies of cat flea.
[Mh] Termos MeSH primário: Apicomplexa/fisiologia
Ctenocephalides/parasitologia
[Mh] Termos MeSH secundário: Animais
Apicomplexa/ultraestrutura
Ctenocephalides/crescimento & desenvolvimento
Ctenocephalides/ultraestrutura
Feminino
Interações Hospedeiro-Parasita
Larva/crescimento & desenvolvimento
Larva/parasitologia
Larva/ultraestrutura
Masculino
Oocistos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170928
[Lr] Data última revisão:
170928
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170112
[St] Status:MEDLINE
[do] DOI:10.1017/S0031182016002122


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[PMID]:28043384
[Au] Autor:White WH; Riggs KL; Totten ML; Snyder DE; McCoy CM; Young DR
[Ad] Endereço:Elanco Animal Health, A Division of Eli Lilly & Company, Greenfield, IN, USA.
[Ti] Título:Initial evaluations of the effectiveness of spinetoram as a long-acting, oral systemic pulicide for controlling cat flea (Ctenocephalides felis) infestations on dogs.
[So] Source:Vet Parasitol;233:25-31, 2017 Jan 15.
[Is] ISSN:1873-2550
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Spinetoram is a semi-synthetic, spinosyn class natural product derived from fermentation by the actinomycete, Saccharopolyspora spinosa. Based on LD (50% lethal dose) values against adult cat fleas (Ctenocephalides felis) using an in vitro contact assay, spinetoram was approximately 4-fold more potent than spinosad. Subsequently, two parallel-arm, randomized block design laboratory studies were conducted to evaluate the effectiveness of orally administered spinetoram against experimental C. felis infestations on dogs, when administered as a single dose or multiple doses over a 6-12h interval. In the first study, 16 mixed-breed dogs were allocated to two treatment groups of eight dogs each, based on pre-treatment flea retention rates: negative (placebo) control; and a single dose of spinetoram at 30mg/kg. In the second study, 32 mixed- and pure-breed dogs were allocated to four treatments groups of eight dogs each, based on pre-treatment flea retention rates: negative (placebo) control; a single dose of 60mg/kg; three sequential 20mg/kg oral doses evenly administered over a 6h period; and three sequential 20mg/kg oral doses evenly administered over a 12h period. In both studies, treatments were administered to dogs in a fed state in order to enhance absorption of spinetoram. Therapeutic efficacy was assessed 24h after treatment and persistent efficacy was assessed 48h after each subsequent flea infestation. The duration of effectiveness was assessed at approximate weekly intervals beginning on Day 5 through Day 56 in the first study, or through Day 105 in the second study. In both studies, treatment efficacy was ≥99% (geometric means) through 44 d, with ≥99% efficacy continuing through 72 d for all three treatments in the second study. Efficacy remained ≥90% for at least 8 weeks with a single 30mg/kg dose; through 13 weeks with three sequential 20mg/kg doses; and through 15 weeks with a single 60mg/kg dose. For all time points and in both studies, spinetoram-treated groups had significantly fewer live fleas relative to their respective negative control group (p<0.05). The pharmacokinetic profile in dogs revealed that the mean plasma concentration of spinetoram required for effectiveness against fleas was maintained for at least 3 months regardless of whether the 60mg/kg total body dose was administered as a single bolus or in three sequential 20mg/kg doses administered over a 6-12h period of time. The results of preliminary in vitro and in vivo studies demonstrate that orally administered spinetoram was well tolerated, and provides long lasting effectiveness against C. felis infestations on dogs.
[Mh] Termos MeSH primário: Doenças do Cão/tratamento farmacológico
Infestações por Pulgas/veterinária
Macrolídeos/administração & dosagem
[Mh] Termos MeSH secundário: Administração Oral
Animais
Antiparasitários/administração & dosagem
Antiparasitários/sangue
Antiparasitários/farmacocinética
Antiparasitários/farmacologia
Ctenocephalides/efeitos dos fármacos
Cães
Feminino
Infestações por Pulgas/tratamento farmacológico
Macrolídeos/sangue
Macrolídeos/farmacocinética
Macrolídeos/farmacologia
Masculino
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Antiparasitic Agents); 0 (Macrolides); YGZ1037ELN (spinetoram)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170104
[St] Status:MEDLINE


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[PMID]:28011733
[Au] Autor:Rust MK; Hemsarth WL
[Ad] Endereço:Department of Entomology, University of California, Riverside, CA 92521-0314 (michael.rust@ucr.edu).
[Ti] Título:Intrinsic Activity of IGRs Against Larval Cat Fleas.
[So] Source:J Med Entomol;54(2):418-421, 2017 Mar 01.
[Is] ISSN:1938-2928
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Insect growth regulators (IGRs) such as lufenuron, methoprene, and pyriproxyfen have been important tools in the integrated pest management of cat fleas, Ctenocephalides felis (Bouché), for the past two decades. Other IGRs have been registered for the control of termite, dipteran, and lepidopterous pests including chlorfluazuron, cyromazine, dicyclanil, and precocene I, but have been not tested against C. felis. The intrinsic activity of IGRs was determined by exposing larvae to treated larval rearing media. The LC50s of chlorfluazuron, cyromazine, dicyclanil, lufenuron, and precocene I against cat fleas were 0.19, 2.66, 0.04, 0.20, and 10.97 ppm, respectively. The LC95s of chlorfluazuron, cyromazine, dicyclanil, lufenuron, and precocene I were 0.78, 51.24, 0.30, 0.62, and 175.05, respectively. The regression slopes of chlorfluazuron and lufenuron were 2.65 ± 0.24 and 3.40 ± 0.45 (SEM), respectively, and considerably steeper than the other IGRs tested (1.51 to 1.74). The intrinsic activity of IGRs tested is summarized as dicyclanil > chlorfluazuron = lufenuron > cyromazine > precocene I. The responses of the laboratory UCR strain to these IGRs can serve as a baseline of susceptibility until a more susceptible cat flea strain is found. Chlorfluazuron and dicyclanil look like promising candidates against cat fleas.
[Mh] Termos MeSH primário: Doenças do Gato/parasitologia
Ctenocephalides/efeitos dos fármacos
Infestações por Pulgas/veterinária
Inseticidas/farmacologia
Hormônios Juvenis/farmacologia
Larva/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Doenças do Gato/tratamento farmacológico
Gatos
Ctenocephalides/crescimento & desenvolvimento
Infestações por Pulgas/tratamento farmacológico
Infestações por Pulgas/parasitologia
Larva/crescimento & desenvolvimento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Insecticides); 0 (Juvenile Hormones)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170804
[Lr] Data última revisão:
170804
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161225
[St] Status:MEDLINE
[do] DOI:10.1093/jme/tjw201


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[PMID]:27790856
[Au] Autor:Tu N; Carroll RK; Weiss A; Shaw LN; Nicolas G; Thomas S; Lima A; Okaro U; Anderson B
[Ad] Endereço:Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
[Ti] Título:A family of genus-specific RNAs in tandem with DNA-binding proteins control expression of the badA major virulence factor gene in Bartonella henselae.
[So] Source:Microbiologyopen;6(2), 2017 Apr.
[Is] ISSN:2045-8827
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Bartonella henselae is a gram-negative zoonotic bacterium that causes infections in humans including endocarditis and bacillary angiomatosis. B. henselae has been shown to grow as large aggregates and form biofilms in vitro. The aggregative growth and the angiogenic host response requires the trimeric autotransporter adhesin BadA. We examined the transcriptome of the Houston-1 strain of B. henselae using RNA-seq revealing nine novel, highly-expressed intergenic transcripts (Bartonella regulatory transcript, Brt1-9). The Brt family of RNAs is unique to the genus Bartonella and ranges from 194 to 203 nucleotides with high homology and stable predicted secondary structures. Immediately downstream of each of the nine RNA genes is a helix-turn-helix DNA-binding protein (transcriptional regulatory protein, Trp1-9) that is poorly transcribed under the growth conditions used for RNA-seq. Using knockdown or overexpressing strains, we show a role of both the Brt1 and Trp1 in the regulation of badA and also in biofilm formation. Based on these data, we hypothesize that Brt1 is a trans-acting sRNA that also serves as a cis-acting riboswitch to control the expression of badA. This family of RNAs together with the downstream Trp DNA-binding proteins represents a novel coordinated regulatory circuit controlling expression of virulence-associated genes in the bartonellae.
[Mh] Termos MeSH primário: Angiomatose Bacilar/microbiologia
Bartonella henselae/genética
Bartonella henselae/patogenicidade
RNA Bacteriano/genética
Fatores de Virulência/genética
[Mh] Termos MeSH secundário: Animais
Proteínas de Bactérias/biossíntese
Proteínas de Bactérias/genética
Bartonella henselae/isolamento & purificação
Sequência de Bases
Ctenocephalides/microbiologia
Proteínas de Ligação a DNA/genética
Proteínas de Ligação a DNA/metabolismo
Regulação Bacteriana da Expressão Gênica
Técnicas de Silenciamento de Genes
Genoma Bacteriano/genética
Seres Humanos
Proteínas de Membrana Transportadoras/genética
Análise de Sequência de RNA
Transcriptoma/genética
Fatores de Virulência/biossíntese
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bacterial Proteins); 0 (BadA protein, Bartonella henselae); 0 (DNA-Binding Proteins); 0 (Membrane Transport Proteins); 0 (RNA, Bacterial); 0 (Virulence Factors)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170713
[Lr] Data última revisão:
170713
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161030
[St] Status:MEDLINE
[do] DOI:10.1002/mbo3.420


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[PMID]:27991415
[Au] Autor:Beugnet F; Halos L; Lebon W; Liebenberg J
[Ad] Endereço:Merial S.A.S., 29 Av. Tony Garnier, 69007 Lyon, France.
[Ti] Título:Assessment of the efficacy of a topical combination of fipronil-permethrin (Frontline Tri-Act /Frontect ) against egg laying and adult emergence of the cat flea (Ctenocephalides felis) in dogs.
[Ti] Título:Évaluation de l'efficacité d'une association topique de fipronil-perméthrine (Frontline Tri-Act /Frontect ) contre la ponte et l'émergence de la puce du chat (Ctenocephalides felis) chez le chien..
[So] Source:Parasite;23:57, 2016.
[Is] ISSN:1776-1042
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:This study was conducted to assess the prevention of egg laying and the inhibition of the emergence of the cat flea (Ctenocephalides felis) resulting from the application of a combination of fipronil and permethrin (Frontline Tri-Act /Frontect , Merial) on dogs. Sixteen healthy dogs were included after pre-treatment live flea counts and randomly allocated to two groups. Eight dogs served as untreated controls and 8 dogs were treated on Day 0 and Day 30 with topical application of fipronil/permethrin at the minimum dose of 6.76 mg/kg fipronil and 50.48 mg/kg permethrin. On days -2, 7, 21, 28, 42 and 56, each dog was infested with 100 fleas. Flea eggs were collected from each dog in individual trays from 12 to 36 h after treatment or each flea re-infestation. All fleas were removed by combing and counted 36 h after treatment or infestations. The collected eggs were counted and incubated for 28 days for larval development and adult emergence assessment. The curative efficacy of Frontline Tri-Act /Frontect against adult fleas 36 h after treatment was 95.3% and the efficacy remained 100% after subsequent flea infestations for 8 weeks. Compared to the control group, the treatment reduced egg laying by 84.5% within 36 h after first treatment and was 99.9%, 100%, 100%, 100%, 100% on collection days 7, 21, 29, 43 and 57, respectively. Frontline Tri-Act /Frontect reduced by 28.7% the emergence of new adult fleas from eggs laid during the 48 h of pre-treatment infestation. The inhibition of adult emergence from incubated flea eggs could not be assessed after flea re-infestation in the treated group as no eggs were collected.
[Mh] Termos MeSH primário: Ctenocephalides/efeitos dos fármacos
Doenças do Cão/tratamento farmacológico
Infestações por Pulgas/veterinária
Inseticidas/administração & dosagem
Permetrina/administração & dosagem
Pirazóis/administração & dosagem
[Mh] Termos MeSH secundário: Administração Tópica
Animais
Gatos
Ctenocephalides/fisiologia
Doenças do Cão/parasitologia
Cães
Combinação de Medicamentos
Feminino
Infestações por Pulgas/tratamento farmacológico
Infestações por Pulgas/parasitologia
Masculino
Oviposição/efeitos dos fármacos
Contagem de Ovos de Parasitas/veterinária
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Drug Combinations); 0 (Insecticides); 0 (Pyrazoles); 509F88P9SZ (Permethrin); QGH063955F (fipronil)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170810
[Lr] Data última revisão:
170810
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161220
[St] Status:MEDLINE


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[PMID]:27692320
[Au] Autor:Magalhães VS; Cid YP; Ferreira TP; Medeiros DMV; de S O Batista LC; Correia TR; Albert ALM; Scott FB
[Ad] Endereço:Animal Parasitology Department, Federal Rural University of Rio de Janeiro (UFRRJ), BR 465, Km. 7, 23897-000 Seropédica, RJ, Brazil. Electronic address: vsmagalhaes@gmail.com.
[Ti] Título:Evaluation of pharmacokinetics and efficacy of ivermectin following oral administration in dogs against experimental infection of Ctenocephalides felis felis and Rhipicephalus sanguineus.
[So] Source:Vet Parasitol;228:167-171, 2016 Sep 15.
[Is] ISSN:1873-2550
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:With the increasing number of pets in home the human-animal relationship is increasingly close and care about control disease growing. Ivermectin (IVM) is frequently used because its proven safety. IVM is recommended for the treatment of demodectic scabies and prevention of heartworm in dogs, but informally is extremely used to control of Ctenocephalides felis felis and Rhipicephalus sanguineus. The aim of this study is evaluate the use of IVM in dogs, by the oral route at 0.6µg/kg dose, against experimental infection of these parasites using the construction of the plasma concentration curve and efficacy study. A IVM quantification method in canine plasma using HPLC-FL was developed and validated based on RE n°899/03 ANVISA. The samples collected during the efficacy test was analyzed by this validated method and prove C of 350ng/mL at 4h (t ) and AUC of 8411ng/h/mL. Spite of formulation have shown good absorption, the highest efficiency values found for Rhipcephalus sanguineus and Ctenocephalides felis felis were very low, 35% and 67% respectively, demonstrating this not be the most appropriate treatment for the control of these parasites.
[Mh] Termos MeSH primário: Antiparasitários/farmacocinética
Ctenocephalides/efeitos dos fármacos
Doenças do Cão/prevenção & controle
Ivermectina/farmacocinética
Rhipicephalus sanguineus/efeitos dos fármacos
[Mh] Termos MeSH secundário: Administração Oral
Animais
Antiparasitários/administração & dosagem
Doenças do Cão/parasitologia
Cães
Infestações por Pulgas/prevenção & controle
Infestações por Pulgas/veterinária
Ivermectina/administração & dosagem
Ivermectina/sangue
Masculino
Infestações por Carrapato/prevenção & controle
Infestações por Carrapato/veterinária
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antiparasitic Agents); 70288-86-7 (Ivermectin)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170807
[Lr] Data última revisão:
170807
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161004
[St] Status:MEDLINE


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[PMID]:27537367
[Au] Autor:Maina AN; Fogarty C; Krueger L; Macaluso KR; Odhiambo A; Nguyen K; Farris CM; Luce-Fedrow A; Bennett S; Jiang J; Sun S; Cummings RF; Richards AL
[Ad] Endereço:Naval Medical Research Center, Silver Spring, MD, United States of America.
[Ti] Título:Rickettsial Infections among Ctenocephalides felis and Host Animals during a Flea-Borne Rickettsioses Outbreak in Orange County, California.
[So] Source:PLoS One;11(8):e0160604, 2016.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Due to a resurgence of flea-borne rickettsioses in Orange County, California, we investigated the etiologies of rickettsial infections of Ctenocephalides felis, the predominant fleas species obtained from opossums (Didelphis virginiana) and domestic cats (Felis catus), collected from case exposure sites and other areas in Orange County. In addition, we assessed the prevalence of IgG antibodies against spotted fever group (SFGR) and typhus group (TGR) rickettsiae in opossum sera. Of the 597 flea specimens collected from opossums and cats, 37.2% tested positive for Rickettsia. PCR and sequencing of rickettsial genes obtained from C. felis flea DNA preparations revealed the presence of R. typhi (1.3%), R. felis (28.0%) and R. felis-like organisms (7.5%). Sera from opossums contained TGR-specific (40.84%), but not SFGR-specific antibodies. The detection of R. felis and R. typhi in the C. felis fleas in Orange County highlights the potential risk for human infection with either of these pathogens, and underscores the need for further investigations incorporating specimens from humans, animal hosts, and invertebrate vectors in endemic areas. Such studies will be essential for establishing a link in the ongoing flea-borne rickettsioses outbreaks.
[Mh] Termos MeSH primário: Gatos/parasitologia
Ctenocephalides/microbiologia
Infestações por Pulgas/veterinária
Insetos Vetores/microbiologia
Gambás/parasitologia
Infecções por Rickettsia/veterinária
Rickettsia/isolamento & purificação
[Mh] Termos MeSH secundário: Animais
California/epidemiologia
Gatos/sangue
Gatos/microbiologia
Surtos de Doenças
Infestações por Pulgas/complicações
Seres Humanos
Imunoglobulina G/sangue
Gambás/sangue
Gambás/microbiologia
Infecções por Rickettsia/sangue
Infecções por Rickettsia/epidemiologia
Infecções por Rickettsia/transmissão
Rickettsia felis/isolamento & purificação
Rickettsia typhi/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Immunoglobulin G)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170804
[Lr] Data última revisão:
170804
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160819
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0160604



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