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[PMID]: 29262375 [Au] Autor: Cochet-Escartin O; Locke TT; Shi WH; Steele RE; Collins ES [Ad] Endereço: Department of Physics, University of California, San Diego, La Jolla, California. [Ti] Título: Physical Mechanisms Driving Cell Sorting in Hydra. [So] Source: Biophys J;113(12):2827-2841, 2017 Dec 19. [Is] ISSN: 1542-0086 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Cell sorting, whereby a heterogeneous cell mixture organizes into distinct tissues, is a fundamental patterning process in development. Hydra is a powerful model system for carrying out studies of cell sorting in three dimensions, because of its unique ability to regenerate after complete dissociation into individual cells. The physicists Alfred Gierer and Hans Meinhardt recognized Hydra's self-organizing properties more than 40 years ago. However, what drives cell sorting during regeneration of Hydra from cell aggregates is still debated. Differential motility and differential adhesion have been proposed as driving mechanisms, but the available experimental data are insufficient to distinguish between these two. Here, we answer this longstanding question by using transgenic Hydra expressing fluorescent proteins and a multiscale experimental and numerical approach. By quantifying the kinematics of single cell and whole aggregate behaviors, we show that no differences in cell motility exist among cell types and that sorting dynamics follow a power law with an exponent of ∼0.5. Additionally, we measure the physical properties of separated tissues and quantify their viscosities and surface tensions. Based on our experimental results and numerical simulations, we conclude that tissue interfacial tensions are sufficient to explain cell sorting in aggregates of Hydra cells. Furthermore, we demonstrate that the aggregate's geometry during sorting is key to understanding the sorting dynamics and explains the exponent of the power law behavior. Our results answer the long standing question of the physical mechanisms driving cell sorting in Hydra cell aggregates. In addition, they demonstrate how powerful this organism is for biophysical studies of self-organization and pattern formation. [Mh] Termos MeSH primário: Fenômenos Biofísicos Hydra/citologia [Mh] Termos MeSH secundário: Animais Adesão Celular Agregação Celular Modelos Biológicos Análise de Célula Única [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1801 [Cu] Atualização por classe: 180210 [Lr] Data última revisão: 180210 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171221 [St] Status: MEDLINE

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[PMID]: 28720323 [Au] Autor: Reddy PC; Ubhe S; Sirwani N; Lohokare R; Galande S [Ad] Endereço: Centre of Excellence in Epigenetics, Indian Institute of Science Education and Research, Dr. Homi Bhabha Road, Pune 411008, India. [Ti] Título: Rapid divergence of histones in Hydrozoa (Cnidaria) and evolution of a novel histone involved in DNA damage response in hydra. [So] Source: Zoology (Jena);123:53-63, 2017 Aug. [Is] ISSN: 1873-2720 [Cp] País de publicação: Germany [La] Idioma: eng [Ab] Resumo: Histones are fundamental components of chromatin in all eukaryotes. Hydra, an emerging model system belonging to the basal metazoan phylum Cnidaria, provides an ideal platform to understand the evolution of core histone components at the base of eumetazoan phyla. Hydra exhibits peculiar properties such as tremendous regenerative capacity, lack of organismal senescence and rarity of malignancy. In light of the role of histone modifications and histone variants in these processes it is important to understand the nature of histones themselves and their variants in hydra. Here, we report identification of the complete repertoire of histone-coding genes in the Hydra magnipapillata genome. Hydra histones were classified based on their copy numbers, gene structure and other characteristic features. Genomic organization of canonical histone genes revealed the presence of H2A-H2B and H3-H4 paired clusters in high frequency and also a cluster with all core histones along with H1. Phylogenetic analysis of identified members of H2A and H2B histones suggested rapid expansion of these groups in Hydrozoa resulting in the appearance of unique subtypes. Amino acid sequence level comparisons of H2A and H2B forms with bilaterian counterparts suggest the possibility of a highly mobile nature of nucleosomes in hydra. Absolute quantitation of transcripts confirmed the high copy number of histones and supported the canonical nature of H2A. Furthermore, functional characterization of H2A.X.1 and a unique variant H2A.X.2 in the gastric region suggest their role in the maintenance of genome integrity and differentiation processes. These findings provide insights into the evolution of histones and their variants in hydra. [Mh] Termos MeSH primário: Evolução Molecular Histonas/metabolismo Hydra/metabolismo [Mh] Termos MeSH secundário: Sequência de Aminoácidos Animais Clonagem Molecular Dano ao DNA Regulação da Expressão Gênica/fisiologia Variação Genética Histonas/genética Hydra/genética Filogenia RNA/genética RNA/metabolismo [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Histones); 63231-63-0 (RNA) [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 170925 [Lr] Data última revisão: 170925 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170720 [St] Status: MEDLINE

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[PMID]: 28662098 [Au] Autor: Hartmann AM; Pisella LI; Medina I; Nothwang HG [Ad] Endereço: Neurogenetics Group, School of Medicine and Health Sciences, Carl von Ossietzky University Oldenburg, Oldenburg, Germany. [Ti] Título: Molecular cloning and biochemical characterization of two cation chloride cotransporter subfamily members of Hydra vulgaris. [So] Source: PLoS One;12(6):e0179968, 2017. [Is] ISSN: 1932-6203 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Cation Chloride Cotransporters (CCCs) comprise secondary active membrane proteins mainly mediating the symport of cations (Na+, K+) coupled with chloride (Cl-). They are divided into K+-Cl- outward transporters (KCCs), the Na+-K+-Cl- (NKCCs) and Na+-Cl- (NCCs) inward transporters, the cation chloride cotransporter interacting protein CIP1, and the polyamine transporter CCC9. KCCs and N(K)CCs are established in the genome since eukaryotes and metazoans, respectively. Most of the physiological and functional data were obtained from vertebrate species. To get insights into the basal functional properties of KCCs and N(K)CCs in the metazoan lineage, we cloned and characterized KCC and N(K)CC from the cnidarian Hydra vulgaris. HvKCC is composed of 1,032 amino-acid residues. Functional analyses revealed that hvKCC mediates a Na+-independent, Cl- and K+ (Tl+)-dependent cotransport. The classification of hvKCC as a functional K-Cl cotransporter is furthermore supported by phylogenetic analyses and a similar structural organization. Interestingly, recently obtained physiological analyses indicate a role of cnidarian KCCs in hyposmotic volume regulation of nematocytes. HvN(K)CC is composed of 965 amino-acid residues. Phylogenetic analyses and structural organization suggest that hvN(K)CC is a member of the N(K)CC subfamily. However, no inorganic ion cotransport function could be detected using different buffer conditions. Thus, hvN(K)CC is a N(K)CC subfamily member without a detectable inorganic ion cotransporter function. Taken together, the data identify two non-bilaterian solute carrier 12 (SLC12) gene family members, thereby paving the way for a better understanding of the evolutionary paths of this important cotransporter family. [Mh] Termos MeSH primário: Hydra/metabolismo Simportadores de Cloreto de Sódio-Potássio/metabolismo [Mh] Termos MeSH secundário: Sequência de Aminoácidos Animais Clonagem Molecular Estrutura Secundária de Proteína Simportadores de Cloreto de Sódio-Potássio/química Simportadores de Cloreto de Sódio-Potássio/genética [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Sodium-Potassium-Chloride Symporters) [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171003 [Lr] Data última revisão: 171003 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170630 [St] Status: MEDLINE [do] DOI: 10.1371/journal.pone.0179968

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[PMID]: 28341397 [Au] Autor: Dellamatrice PM; Silva-Stenico ME; Moraes LA; Fiore MF; Monteiro RT [Ad] Endereço: Centro de Energia Nuclear na Agricultura, Laboratório de Ecologia Aplicada, Piracicaba, SP, Brazil. [Ti] Título: Degradation of textile dyes by cyanobacteria. [So] Source: Braz J Microbiol;48(1):25-31, 2017 Jan - Mar. [Is] ISSN: 1678-4405 [Cp] País de publicação: Brazil [La] Idioma: eng [Ab] Resumo: Dyes are recalcitrant compounds that resist conventional biological treatments. The degradation of three textile dyes (Indigo, RBBR and Sulphur Black), and the dye-containing liquid effluent and solid waste from the Municipal Treatment Station, Americana, São Paulo, Brazil, by the cyanobacteria Anabaena flos-aquae UTCC64, Phormidium autumnale UTEX1580 and Synechococcus sp. PCC7942 was evaluated. The dye degradation efficiency of the cyanobacteria was compared with anaerobic and anaerobic-aerobic systems in terms of discolouration and toxicity evaluations. The discoloration was evaluated by absorption spectroscopy. Toxicity was measured using the organisms Hydra attenuata, the alga Selenastrum capricornutum and lettuce seeds. The three cyanobacteria showed the potential to remediate textile effluent by removing the colour and reducing the toxicity. However, the growth of cyanobacteria on sludge was slow and discoloration was not efficient. The cyanobacteria P. autumnale UTEX1580 was the only strain that completely degraded the indigo dye. An evaluation of the mutagenicity potential was performed by use of the micronucleus assay using Allium sp. No mutagenicity was observed after the treatment. Two metabolites were produced during the degradation, anthranilic acid and isatin, but toxicity did not increase after the treatment. The cyanobacteria showed the ability to degrade the dyes present in a textile effluent; therefore, they can be used in a tertiary treatment of effluents with recalcitrant compounds. [Mh] Termos MeSH primário: Corantes/metabolismo Cianobactérias/metabolismo [Mh] Termos MeSH secundário: Aerobiose Allium/efeitos dos fármacos Anaerobiose Animais Biotransformação Brasil Clorófitas/efeitos dos fármacos Corantes/toxicidade Hydra/efeitos dos fármacos Resíduos Industriais Alface/efeitos dos fármacos Mutagênicos/metabolismo Sementes/efeitos dos fármacos Têxteis Espectroscopia por Absorção de Raios X [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Coloring Agents); 0 (Industrial Waste); 0 (Mutagens) [Em] Mês de entrada: 1704 [Cu] Atualização por classe: 170407 [Lr] Data última revisão: 170407 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170326 [St] Status: MEDLINE

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[PMID]: 28248594 [Au] Autor: Ambrosone A; Roopin M; Pelaz B; Abdelmonem AM; Ackermann LM; Mattera L; Allocca M; Tino A; Klapper M; Parak WJ; Levy O; Tortiglione C [Ad] Endereço: a Istituto di Scienze Applicate e Sistemi Intelligenti "E. Caianiello", Consiglio Nazionale delle Ricerche , Pozzuoli , Italy. [Ti] Título: Dissecting common and divergent molecular pathways elicited by CdSe/ZnS quantum dots in freshwater and marine sentinel invertebrates. [So] Source: Nanotoxicology;11(2):289-303, 2017 Mar. [Is] ISSN: 1743-5404 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Water ecosystems represent main targets of unintentional contamination of nanomaterials, due to industrial waste or other anthropogenic activities. Nanoparticle insult to living organisms may occur in a sequential way, first by chemical interactions of the material with the target membrane, then by progressive internalisation and interaction with cellular structures and organelles. These events trigger a signal transduction, through which cells modulate molecular pathway in order to respond and survive to the external elicitation. Therefore, the analysis of the global changes of the molecular machinery, possibly induced in an organism upon exposure to a given nanomaterial, may provide unique clues for proper and exhaustive risk assessment. Here, we tested the impact of core/shell CdSe/ZnS QDs coated by a positively charged polymer on two aquatic species, the polyp Hydra vulgaris and the coral S. pistillata, representative of freshwater and sea habitats, respectively. By using reliable approaches based on animal behaviour and physiology together with a whole transcriptomic profiling, we determined several toxicity endpoints. Despite the difference in the efficiency of uptake, both species were severely affected by QD treatment, resulting in dramatic morphological damages and tissue bleaching. Global transcriptional changes were also detected in both organisms, but presenting different temporal dynamics, suggesting both common and divergent functional responses in the two sentinel organisms. Due to the striking conservation of structure and genomic organisation among animals throughout evolution, our expression profiling offers new clues to identify novel molecular markers and pathways for comparative transcriptomics of nanotoxicity. [Mh] Termos MeSH primário: Antozoários/efeitos dos fármacos Compostos de Cádmio/toxicidade Água Doce/química Hydra/efeitos dos fármacos Pontos Quânticos/toxicidade Compostos de Selênio/toxicidade Compostos de Zinco/toxicidade [Mh] Termos MeSH secundário: Animais Antozoários/genética Antozoários/metabolismo Compostos de Cádmio/química Coloides Endocitose/efeitos dos fármacos Perfilação da Expressão Gênica Hydra/genética Hydra/metabolismo Pontos Quânticos/química Compostos de Selênio/química Análise de Sequência de RNA Transcriptoma/efeitos dos fármacos Compostos de Zinco/química [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Cadmium Compounds); 0 (Colloids); 0 (Selenium Compounds); 0 (Zinc Compounds); A7F646JC5C (cadmium selenide); OWX23150D5 (zinc selenide) [Em] Mês de entrada: 1706 [Cu] Atualização por classe: 170626 [Lr] Data última revisão: 170626 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170302 [St] Status: MEDLINE [do] DOI: 10.1080/17435390.2017.1295111

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[PMID]: 28222982 [Au] Autor: Zeeshan M; Murugadas A; Ghaskadbi S; Ramaswamy BR; Akbarsha MA [Ad] Endereço: Mahatma Gandhi-Doerenkamp Center, Bharathidasan University, Tiruchirappalli 620024, India; Dept. of Environmental Biotechnology, Bharathidasan University, Tiruchirappalli 620024, India. [Ti] Título: Ecotoxicological assessment of cobalt using Hydra model: ROS, oxidative stress, DNA damage, cell cycle arrest, and apoptosis as mechanisms of toxicity. [So] Source: Environ Pollut;224:54-69, 2017 May. [Is] ISSN: 1873-6424 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: The mechanisms underlying cobalt toxicity in aquatic species in general and cnidarians in particular remain poorly understood. Herein we investigated cobalt toxicity in a Hydra model from morphological, histological, developmental, and molecular biological perspectives. Hydra, exposed to cobalt (0-60 mg/L), were altered in morphology, histology, and regeneration. Exposure to standardized sublethal doses of cobalt impaired feeding by affecting nematocytes, which in turn affected reproduction. At the cellular level, excessive ROS generation, as the principal mechanism of action, primarily occurred in the lysosomes, which was accompanied by the upregulation of expression of the antioxidant genes SOD, GST, GPx, and G6PD. The number of Hsp70 and FoxO transcripts also increased. Interestingly, the upregulations were higher in the 24-h than in the 48-h time-point group, indicating that ROS overwhelmed the cellular defense mechanisms at the latter time-point. Comet assay revealed DNA damage. Cell cycle analysis indicated the induction of apoptosis accompanied or not by cell cycle arrest. Immunoblot analyses revealed that cobalt treatment triggered mitochondria-mediated apoptosis as inferred from the modulation of the key proteins Bax, Bcl-2, and caspase-3. From this data, we suggest the use of Hydra as a model organism for the risk assessment of heavy metal pollution in aquatic ecosystems. [Mh] Termos MeSH primário: Apoptose/efeitos dos fármacos Pontos de Checagem do Ciclo Celular/efeitos dos fármacos Cobalto/toxicidade Dano ao DNA/efeitos dos fármacos Hydra/efeitos dos fármacos Espécies Reativas de Oxigênio/metabolismo [Mh] Termos MeSH secundário: Animais Antioxidantes/metabolismo Caspase 3/metabolismo Ensaio Cometa Proteínas de Choque Térmico HSP70/metabolismo Lisossomos/efeitos dos fármacos Lisossomos/metabolismo Metais Pesados/toxicidade Mitocôndrias Estresse Oxidativo [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Antioxidants); 0 (HSP70 Heat-Shock Proteins); 0 (Metals, Heavy); 0 (Reactive Oxygen Species); 3G0H8C9362 (Cobalt); EC 3.4.22.- (Caspase 3) [Em] Mês de entrada: 1705 [Cu] Atualização por classe: 170517 [Lr] Data última revisão: 170517 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170223 [St] Status: MEDLINE

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[PMID]: 27995409 [Au] Autor: Traversetti L; Del Grosso F; Malafoglia V; Colasanti M; Ceschin S; Larsen S; Scalici M [Ad] Endereço: Department of Sciences, University Rome Tre, V.le G. Marconi 446, Rome, 00146, Italy. [Ti] Título: The Hydra regeneration assay reveals ecological risks in running waters: a new proposal to detect environmental teratogenic threats. [So] Source: Ecotoxicology;26(2):184-195, 2017 Mar. [Is] ISSN: 1573-3017 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: The regenerative ability of Hydra vulgaris was tested as potential biomarker for the development of a new eco-toxicological index. The test is based on the regeneration rate and the aberration frequency of the columna (body and adhesive foot) after separation from head and tentacles by a bistoury. Particularly, 45 columnae were submerged in the rearing solution (that is Hydra medium) to have control, and 285 in potential contaminated waters to have treatments, collected from 19 sites along 10 rivers in central Italy. ANCOVA and chi-square tests were used to compare values from each site to a laboratory control. Subsequently the values on regeneration rate and aberration frequency were inserted in a double entry matrix, where the match of the two entries in the matrix provides the score of the proposed Teratogenic Risk Index (TRI). Each score corresponded to one of the 5 teratogenic risk classes, to which a risk level was associated: from 1 (no risk) to 5 (very high risk). On the whole, 32% of the studied sites were classified as no teratogenic risk while the remaining showed a variable risk level from low to very high. This study proposed for the first time an early warning system to detect the presence of teratogens in running waters, providing a rapid and cost-effective evaluation method. Therefore, TRI may contribute to initiate adequate measures to manage riverine habitats, and to monitor the running water teratogenic status. Specifically, this index may provide the opportunity to identify the disturbance sources and then to drive the decisions, together with competent authorities, on the catchment and landscape management and on the possible use of waters for urban, agricultural, and industrial activities, since they may show significant effects on the human health. [Mh] Termos MeSH primário: Ecotoxicologia/métodos Monitoramento Ambiental/métodos Hydra/efeitos dos fármacos Teratogênios/análise [Mh] Termos MeSH secundário: Animais Biomarcadores Hydra/crescimento & desenvolvimento Rios/química Teratogênios/toxicidade Poluentes Químicos da Água/análise Poluentes Químicos da Água/toxicidade [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Biomarkers); 0 (Teratogens); 0 (Water Pollutants, Chemical) [Em] Mês de entrada: 1703 [Cu] Atualização por classe: 171019 [Lr] Data última revisão: 171019 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 161221 [St] Status: MEDLINE [do] DOI: 10.1007/s10646-016-1753-4

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[PMID]: 27840906 [Au] Autor: Sinkovics JG [Ad] Endereço: St. Joseph Hospital's Cancer Institute Affiliated with the H.L. Moffitt Comprehensive Cancer Center; Department of Molecular Medicine, The University of South Florida Morsani College of Medicine, Tampa, FL, USA. [Ti] Título: [Erratum] The cnidarian origin of the proto-oncogenes NF-κB/STAT and WNT-like oncogenic pathway drives the ctenophores (Review). [So] Source: Int J Oncol;50(1):338, 2017 Jan. [Is] ISSN: 1791-2423 [Cp] País de publicação: Greece [La] Idioma: eng [Ab] Resumo: After the publication of the article, the author noted that there was an error on page 1212, right column, paragraph entitled 'Virus carrier algal symbionts'. The word Hydra virilis should be written as Hydra viridis/viridissima. [the original article was published in the International Journal of Oncology 47: 1211-1229, 2015; DOI: 10.3892/ijo.2015.3102]. [Mh] Termos MeSH primário: Cnidários Ctenóforos [Mh] Termos MeSH secundário: Animais Seres Humanos Hydra NF-kappa B Proto-Oncogenes [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (NF-kappa B) [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171026 [Lr] Data última revisão: 171026 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 161115 [St] Status: MEDLINE [do] DOI: 10.3892/ijo.2016.3762

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[PMID]: 27491450 [Au] Autor: Tökölyi J; Osz Z; Sebestyén F; Barta Z [Ad] Endereço: MTA-DE "Lendület" Behavioral Ecology Research Group, Department of Evolutionary Zoology, University of Debrecen, Egyetem tér 1, 4032 Debrecen, Hungary. Electronic address: jtokolyi@vocs.unideb.hu. [Ti] Título: Resource allocation and post-reproductive degeneration in the freshwater cnidarian Hydra oligactis (Pallas, 1766). [So] Source: Zoology (Jena);120:110-116, 2017 Feb. [Is] ISSN: 1873-2720 [Cp] País de publicação: Germany [La] Idioma: eng [Ab] Resumo: Freshwater hydra are among the few animal groups that show negligible senescence and can maintain high survival and reproduction rates when kept under stable conditions in the laboratory. Yet, one species of Hydra (H. oligactis) undergoes a senescence-like process in which polyps degenerate and die after sexual reproduction. The ultimate factors responsible for this phenomenon are unclear. High mortality in reproducing animals could be the consequence of increased allocation of resources to reproduction at the expense of somatic maintenance. This hypothesis predicts that patterns of reproduction and survival are influenced by resource availability. To test this prediction we investigated survival and reproduction at different levels of food availability in 10 lineages of H. oligactis derived from a single Hungarian population. Sexual reproduction was accompanied by reduced survival, but a substantial proportion of animals regenerated after sexual reproduction and continued reproducing asexually. Polyps belonging to different lineages showed differences in their propensity to initiate sexual reproduction, gonad number and survival rate. Food availability significantly affected fecundity (number of eggs or testes produced), with the largest number of gonads being produced by animals kept on a high food regime. On the other hand, survival rate was not affected by the amount of food. These results show that survival is conserved at the expense of reproduction in this population when food is low. It remains a question still to be answered why survival is prioritized over reproduction in this population. [Mh] Termos MeSH primário: Hydra/fisiologia [Mh] Termos MeSH secundário: Animais Metabolismo Energético/fisiologia Hungria Reprodução/fisiologia Rios [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 170914 [Lr] Data última revisão: 170914 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 160806 [St] Status: MEDLINE

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[PMID]: 28185543 [Au] Autor: Evangelista D; Tripathi KP; Guarracino MR [Ad] Endereço: Laboratory for Genomics, Transcriptomics and Proteomics (LAB-GTP), High Performance Computing and Networking Institute (ICAR), National Research Council of Italy (CNR) Napoli, Italy, Via Pietro Castellino, Naples, 111, Italy. daniela.evangelista@na.icar.cnr.it. [Ti] Título: An Atlas of annotations of Hydra vulgaris transcriptome. [So] Source: BMC Bioinformatics;17(Suppl 11):360, 2016 Sep 22. [Is] ISSN: 1471-2105 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: BACKGROUND: RNA sequencing takes advantage of the Next Generation Sequencing (NGS) technologies for analyzing RNA transcript counts with an excellent accuracy. Trying to interpret this huge amount of data in biological information is still a key issue, reason for which the creation of web-resources useful for their analysis is highly desiderable. RESULTS: Starting from a previous work, Transcriptator, we present the Atlas of Hydra's vulgaris, an extensible web tool in which its complete transcriptome is annotated. In order to provide to the users an advantageous resource that include the whole functional annotated transcriptome of Hydra vulgaris water polyp, we implemented the Atlas web-tool contains 31.988 accesible and downloadable transcripts of this non-reference model organism. CONCLUSION: Atlas, as a freely available resource, can be considered a valuable tool to rapidly retrieve functional annotation for transcripts differentially expressed in Hydra vulgaris exposed to the distinct experimental treatments. WEB RESOURCE URL: http://www-labgtp.na.icar.cnr.it/Atlas . [Mh] Termos MeSH primário: Bases de Dados Genéticas Sequenciamento de Nucleotídeos em Larga Escala/métodos Hydra/genética Internet Anotação de Sequência Molecular Software Transcriptoma [Mh] Termos MeSH secundário: Animais Genômica/métodos [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1707 [Cu] Atualização por classe: 170726 [Lr] Data última revisão: 170726 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170211 [St] Status: MEDLINE [do] DOI: 10.1186/s12859-016-1172-9

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