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Referências encontradas : 135 [refinar]
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[PMID]:28777808
[Au] Autor:Molakarimi M; Mohseni A; Taghdir M; Pashandi Z; Gorman MA; Parker MW; Naderi-Manesh H; Sajedi RH
[Ad] Endereço:Department of Biochemistry, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran.
[Ti] Título:QM/MM simulations provide insight into the mechanism of bioluminescence triggering in ctenophore photoproteins.
[So] Source:PLoS One;12(8):e0182317, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Photoproteins are responsible for light emission in a variety of marine ctenophores and coelenterates. The mechanism of light emission in both families occurs via the same reaction. However, the arrangement of amino acid residues surrounding the chromophore, and the catalytic mechanism of light emission is unknown for the ctenophore photoproteins. In this study, we used quantum mechanics/molecular mechanics (QM/MM) and site-directed mutagenesis studies to investigate the details of the catalytic mechanism in berovin, a member of the ctenophore family. In the absence of a crystal structure of the berovin-substrate complex, molecular docking was used to determine the binding mode of the protonated (2-hydroperoxy) and deprotonated (2-peroxy anion) forms of the substrate to berovin. A total of 13 mutants predicted to surround the binding site were targeted by site-directed mutagenesis which revealed their relative importance in substrate binding and catalysis. Molecular dynamics simulations and MM-PBSA (Molecular Mechanics Poisson-Boltzmann/surface area) calculations showed that electrostatic and polar solvation energy are +115.65 and -100.42 kcal/mol in the deprotonated form, respectively. QM/MM calculations and pKa analysis revealed the deprotonated form of substrate is unstable due to the generation of a dioxetane intermediate caused by nucleophilic attack of the substrate peroxy anion at its C3 position. This work also revealed that a hydrogen bonding network formed by a D158- R41-Y204 triad could be responsible for shuttling the proton from the 2- hydroperoxy group of the substrate to bulk solvent.
[Mh] Termos MeSH primário: Ctenóforos/metabolismo
Medições Luminescentes
Proteínas Luminescentes/química
Proteínas Luminescentes/metabolismo
Simulação de Dinâmica Molecular
Teoria Quântica
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Animais
Sítios de Ligação
Cristalografia por Raios X
Ctenóforos/crescimento & desenvolvimento
Ligações de Hidrogênio
Cinética
Modelos Moleculares
Simulação de Acoplamento Molecular
Conformação Proteica
Alinhamento de Sequência
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Luminescent Proteins)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170805
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0182317


  2 / 135 MEDLINE  
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[PMID]:28610920
[Au] Autor:Pashandi Z; Molakarimi M; Mohseni A; Sajedi RH; Taghdir M; Naderi-Manesh H
[Ad] Endereço:Department of Biophysics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran.
[Ti] Título:Photoinactivation related dynamics of ctenophore photoproteins: Insights from molecular dynamics simulation under electric-field.
[So] Source:Biochem Biophys Res Commun;490(2):265-270, 2017 Aug 19.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Photoinactivation is a common phenomenon in bioluminescence ctenophore photoproteins (e.g mnemiopsin, berovin and BfosPP) with still unknown mechanism. The activity of coelenterate photoproteins (e.g aequorin), which has high structural similarity with ctenophore photoproteins, is not affected by light. Recently, we have characterized the effects of light on ctenophore photoprotein mnemiopsin, in different conformations, which has demonstrated light induced structural changes, uniquely secondary structures, of both apo and holo mnemiopsin. This paper is further expansion of our previous work, by applying molecular dynamics simulations to investigate photoinactivation related dynamics of berovin at atomistic level, in comparison with aequorin, under the influence of electric component of electromagnetic field. The results have indicated that the intense electric filed could influence structure of both berovin and aequorin but in different manner, whereas moderate electric field only effects on berovin's structure remarkably. In this case, increased helicity of residues E180-M193 and decreased helical contents of L38-D46 and L125-D138 segments are considerable in berovin as well as flexibility elevation of calcium binding loops. These changes cause structural expansion of berovin, especially at N-terminal domain, in direction of electric field. In conclusion, the induced structural changes of mentioned helical parts together with elevated fluctuation of their adjacent segments, N26-D46 and M193-Y206, indicate the influence of light on substrate stabilizing residues, Arg41 and Y204. This condition could presumably leads to inactivation of bioluminescence reaction due to separation of substrate from the cavity of the protein.
[Mh] Termos MeSH primário: Ctenóforos
Eletricidade
Proteínas Luminescentes/metabolismo
Simulação de Dinâmica Molecular
[Mh] Termos MeSH secundário: Animais
Proteínas Luminescentes/química
Processos Fotoquímicos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Luminescent Proteins)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170615
[St] Status:MEDLINE


  3 / 135 MEDLINE  
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[PMID]:28418331
[Au] Autor:Fidler AL; Darris CE; Chetyrkin SV; Pedchenko VK; Boudko SP; Brown KL; Gray Jerome W; Hudson JK; Rokas A; Hudson BG
[Ad] Endereço:Department of Medicine, Division of Nephrology and Hypertension, Vanderbilt University Medical Center, Nashville, United States.
[Ti] Título:Collagen IV and basement membrane at the evolutionary dawn of metazoan tissues.
[So] Source:Elife;6, 2017 Apr 18.
[Is] ISSN:2050-084X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The role of the cellular microenvironment in enabling metazoan tissue genesis remains obscure. Ctenophora has recently emerged as one of the earliest-branching extant animal phyla, providing a unique opportunity to explore the evolutionary role of the cellular microenvironment in tissue genesis. Here, we characterized the extracellular matrix (ECM), with a focus on collagen IV and its variant, spongin short-chain collagens, of non-bilaterian animal phyla. We identified basement membrane (BM) and collagen IV in Ctenophora, and show that the structural and genomic features of collagen IV are homologous to those of non-bilaterian animal phyla and Bilateria. Yet, ctenophore features are more diverse and distinct, expressing up to twenty genes compared to six in vertebrates. Moreover, collagen IV is absent in unicellular sister-groups. Collectively, we conclude that collagen IV and its variant, spongin, are primordial components of the extracellular microenvironment, and as a component of BM, collagen IV enabled the assembly of a fundamental architectural unit for multicellular tissue genesis.
[Mh] Termos MeSH primário: Membrana Basal/química
Colágeno Tipo IV/análise
Colágeno Tipo IV/genética
Ctenóforos/fisiologia
Matriz Extracelular/química
[Mh] Termos MeSH secundário: Animais
Ctenóforos/citologia
Ctenóforos/genética
Ctenóforos/metabolismo
Evolução Molecular
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Collagen Type IV)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170424
[Lr] Data última revisão:
170424
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170419
[St] Status:MEDLINE


  4 / 135 MEDLINE  
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[PMID]:28137975
[Au] Autor:Vandepas LE; Warren KJ; Amemiya CT; Browne WE
[Ad] Endereço:Department of Biology, University of Washington, Seattle, WA 98195, USA.
[Ti] Título:Establishing and maintaining primary cell cultures derived from the ctenophore .
[So] Source:J Exp Biol;220(Pt 7):1197-1201, 2017 Apr 01.
[Is] ISSN:1477-9145
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:We have developed an efficient method for the preparation and maintenance of primary cell cultures isolated from adult , a lobate ctenophore. Our primary cell cultures are derived from tissue explants or enzymatically dissociated cells, and maintained in a complex undefined ctenophore mesogleal serum. These methods can be used to isolate, maintain and visually monitor ctenophore cells to assess proliferation, cellular morphology and cell differentiation in future studies. Exemplar cell types that can be easily isolated from primary cultures include proliferative ectodermal and endodermal cells, motile amebocyte-like cells, and giant smooth muscle cells that exhibit inducible contractile properties. We have also derived 'tissue envelopes' containing sections of endodermal canal surrounded by mesoglea and ectoderm that can be used to monitor targeted cell types in an context. Access to efficient and reliably generated primary cell cultures will facilitate the analysis of ctenophore development, physiology and morphology from a cell biological perspective.
[Mh] Termos MeSH primário: Ctenóforos/citologia
Cultura Primária de Células/métodos
[Mh] Termos MeSH secundário: Animais
Células Cultivadas
Dissecação
Corantes Fluorescentes/análise
Imagem Óptica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fluorescent Dyes)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170908
[Lr] Data última revisão:
170908
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170201
[St] Status:MEDLINE
[do] DOI:10.1242/jeb.152371


  5 / 135 MEDLINE  
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[PMID]:27840906
[Au] Autor:Sinkovics JG
[Ad] Endereço:St. Joseph Hospital's Cancer Institute Affiliated with the H.L. Moffitt Comprehensive Cancer Center; Department of Molecular Medicine, The University of South Florida Morsani College of Medicine, Tampa, FL, USA.
[Ti] Título:[Erratum] The cnidarian origin of the proto-oncogenes NF-κB/STAT and WNT-like oncogenic pathway drives the ctenophores (Review).
[So] Source:Int J Oncol;50(1):338, 2017 Jan.
[Is] ISSN:1791-2423
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:After the publication of the article, the author noted that there was an error on page 1212, right column, paragraph entitled 'Virus carrier algal symbionts'. The word Hydra virilis should be written as Hydra viridis/viridissima. [the original article was published in the International Journal of Oncology 47: 1211-1229, 2015; DOI: 10.3892/ijo.2015.3102].
[Mh] Termos MeSH primário: Cnidários
Ctenóforos
[Mh] Termos MeSH secundário: Animais
Seres Humanos
Hydra
NF-kappa B
Proto-Oncogenes
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (NF-kappa B)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171026
[Lr] Data última revisão:
171026
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161115
[St] Status:MEDLINE
[do] DOI:10.3892/ijo.2016.3762


  6 / 135 MEDLINE  
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[PMID]:27988700
[Au] Autor:Oliveira OM; Miranda TP; Araujo EM; Ayón P; Cedeño-Posso CM; Cepeda-Mercado AA; Córdova P; Cunha AF; Genzano GN; Haddad MA; Mianzan HW; Migotto AE; Miranda LS; Morandini AC; Nagata RM; Nascimento KB; Júnior MN; Palma S; Quiñones J; Rodriguez CS; Scarabino F; Schiariti A; Stampar SN; Tronolone VB; Marques AC
[Ad] Endereço:Centro de Ciências Naturais e Humanas, Universidade Federal do ABC, Rua Arcturus, 03, Jd. Antares, 09606-070-São Bernardo do Campo, SP, Brazil.. otto.oliveira@ufabc.edu.br.
[Ti] Título:Census of Cnidaria (Medusozoa) and Ctenophora from South American marine waters.
[So] Source:Zootaxa;4194(1):zootaxa.4194.1.1, 2016 Nov 17.
[Is] ISSN:1175-5334
[Cp] País de publicação:New Zealand
[La] Idioma:eng
[Ab] Resumo:We have compiled available records in the literature for medusozoan cnidarians and ctenophores of South America. New records of species are also included. Each entry (i.e., identified species or still as yet not determined species referred to as "sp." in the literature) includes a synonymy list for South America, taxonomical remarks, notes on habit, and information on geographical occurrence. We have listed 800 unique determined species, in 958 morphotype entries: 5 cubozoans, 905 hydrozoans, 25 scyphozoans, 3 staurozoans, and 20 ctenophores. Concerning nomenclatural and taxonomical decisions, two authors of this census (Miranda, T.P. & Marques, A.C.) propose Podocoryna quitus as a nomen novum for the junior homonym Hydractinia reticulata (Fraser, 1938a); Euphysa monotentaculata Zamponi, 1983b as a new junior synonym of Euphysa aurata Forbes, 1848; and Plumularia spiralis Milstein, 1976 as a new junior synonym of Plumularia setacea (Linnaeus, 1758). Finally, we also reassign Plumularia oligopyxis Kirchenpauer, 1876 as Kirchenpaueria oligopyxis (Kirchenpauer, 1876) and Sertularella margaritacea Allman, 1885 as Symplectoscyphus margaritaceus (Allman, 1885).
[Mh] Termos MeSH primário: Ctenóforos/classificação
[Mh] Termos MeSH secundário: Distribuição Animal
Animais
Ecossistema
Feminino
Masculino
América do Sul
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170424
[Lr] Data última revisão:
170424
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161219
[St] Status:MEDLINE
[do] DOI:10.11646/zootaxa.4194.1.1


  7 / 135 MEDLINE  
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[PMID]:27420173
[Au] Autor:Martindale MQ
[Ad] Endereço:Whitney Lab for Marine Bioscience, University of Florida, 9505 Oceanshore Blvd, St. Augustine, FL 32080, United States. Electronic address: mqmartin@whitney.ufl.edu.
[Ti] Título:The onset of regenerative properties in ctenophores.
[So] Source:Curr Opin Genet Dev;40:113-119, 2016 Oct.
[Is] ISSN:1879-0380
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Ctenophores are a clade of animals that branch off at the base of the animal tree. They have a unique and delicate body plan, and distinct pattern forming mechanisms at different life history stages. They have a stereotyped embryonic cell lineage and are highly 'mosaic' as embryos, but most have amazing capacity to regenerate as adults. Unfortunately, only a handful of ctenophore species have been studied in detail. This review summarizes the key features of the regenerative properties of adults, and the characteristics of the embryological onset of regenerative abilities. The genomes of several ctenophore species have already been sequenced, and these resources set the stage for more detailed cellular and molecular analysis of body plan patterning in this group.
[Mh] Termos MeSH primário: Padronização Corporal/genética
Ctenóforos/genética
Regeneração/genética
[Mh] Termos MeSH secundário: Animais
Evolução Biológica
Linhagem da Célula/genética
Ctenóforos/crescimento & desenvolvimento
Genoma
Anotação de Sequência Molecular
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171101
[Lr] Data última revisão:
171101
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160716
[St] Status:MEDLINE


  8 / 135 MEDLINE  
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[PMID]:27351593
[Au] Autor:Jager M; Manuel M
[Ad] Endereço:Sorbonne Universités, UPMC Univ Paris 06, CNRS, Institut de Biologie Paris - Seine, UMR 7138 "Evolution Paris - Seine", Case 05, 7 quai St Bernard, 75005 Paris, France.
[Ti] Título:Ctenophores: an evolutionary-developmental perspective.
[So] Source:Curr Opin Genet Dev;39:85-92, 2016 Aug.
[Is] ISSN:1879-0380
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Ctenophores are non-bilaterian metazoans of uncertain phylogenetic position, some recent studies placing them as sister-group to all other animals whereas others suggest this placement is artefactual and ctenophores are more closely allied with cnidarians and bilaterians, with which they share nerve cells, muscles and gut. Available information about developmental genes and their expression and function in ctenophores is reviewed. These data not only unveil some conserved aspects of molecular developmental mechanisms with other basal metazoan lineages, but also can be expected to enlighten the genomic and molecular bases of the evolution of ctenophore-specific traits, including their unique embryonic development, complex anatomy and high cell type diversity.
[Mh] Termos MeSH primário: Ctenóforos/genética
Evolução Molecular
Filogenia
[Mh] Termos MeSH secundário: Animais
Ctenóforos/crescimento & desenvolvimento
Regulação da Expressão Gênica no Desenvolvimento
Genoma
Desenvolvimento Muscular/genética
Neurônios/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171101
[Lr] Data última revisão:
171101
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160629
[St] Status:MEDLINE


  9 / 135 MEDLINE  
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[PMID]:27262669
[Au] Autor:Delpy F; Albouy-Boyer S; Pagano M; Thibault D; Blanchot J; Guilhaumon F; Molinero JC; Bonnet D
[Ad] Endereço:Aix-Marseille University, CNRS/INSU, Université de Toulon, IRD, Mediterranean Institute of Oceanography (MIO) UM 110, 13288 Marseille, France; PROTEE-EBMA, EA 3819, Université de Toulon, 83957 La Garde, France. Electronic address: floriane.delpy@univ-tln.fr.
[Ti] Título:Identifying the drivers of abundance and size of the invasive ctenophore Mnemiopsis leidyi in Northwestern Mediterranean lagoons.
[So] Source:Mar Environ Res;119:114-25, 2016 Aug.
[Is] ISSN:1879-0291
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Acknowledged as among the worst invasive marine species, Mnemiopsis leidyi has spread through European Seas since the mid-1980's. Here we report a bimonthly survey conducted in 2010-11 in three lagoons (Bages-Sigean, Thau and Berre) and at two adjacent coastal stations (Sète and SOMLIT-Marseille) along the French Mediterranean coast. M. leidyi was present only in Berre and Bages-Sigean with maximum abundances observed in late summer. M. leidyi adults were present year round in Berre with the largest organisms (∼6 cm) observed in April. In Bages-Sigean, they occurred in sufficient abundance to be recorded by fishermen between August and November. Multiple linear regressions highlighted that abundance in both lagoons was mainly influenced by direct effects of salinity and chlorophyll-a, and temperature to a lesser extent. While M. leidyi has not yet been recorded in Thau, the lagoon is continually monitored to detect the potential establishment of M. leidyi.
[Mh] Termos MeSH primário: Ctenóforos/fisiologia
Monitoramento Ambiental
Espécies Introduzidas
[Mh] Termos MeSH secundário: Animais
Clorofila/análise
Mar Mediterrâneo
Salinidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
1406-65-1 (Chlorophyll); YF5Q9EJC8Y (chlorophyll a)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170302
[Lr] Data última revisão:
170302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160606
[St] Status:MEDLINE


  10 / 135 MEDLINE  
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[PMID]:27257248
[Au] Autor:Tamm SL
[Ad] Endereço:Eugene Bell Center for Regenerative Biology and Tissue Engineering, Marine Biological Laboratory, Woods Hole, MA 02543, USA. tamm@bu.edu.
[Ti] Título:No surprise that comb jellies poop.
[So] Source:Science;352(6290):1182, 2016 Jun 03.
[Is] ISSN:1095-9203
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Canal Anal/anatomia & histologia
Evolução Biológica
Ctenóforos/anatomia & histologia
[Mh] Termos MeSH secundário: Animais
[Pt] Tipo de publicação:COMMENT; LETTER
[Em] Mês de entrada:1606
[Cu] Atualização por classe:160603
[Lr] Data última revisão:
160603
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160604
[St] Status:MEDLINE
[do] DOI:10.1126/science.aaf8170



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