Base de dados : MEDLINE
Pesquisa : B01.050.500.500 [Categoria DeCS]
Referências encontradas : 3640 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 364 ir para página                         

  1 / 3640 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
[PMID]:29405681
[Au] Autor:Dolomatov S; Sataieva T; Pazovsky G; Zukow W
[Ti] Título:[Neuroendocrine effects of helminthiases (A review)].
[So] Source:Parazitologiia;51(2):97-103, 2017 Mar-Apr.
[Is] ISSN:0031-1847
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:Nowadays the number of patients diagnosed with helminthiases shows tendency for steady growth around the world. During last few years, researches in the field of immunology have again turned their attention towards the question of parasitological immunity and tissue response. Helminthiases and other parasitic diseases in some instances can induce central nervous system disorders and violate human behavioral reactions. Studies have suggested an association between epilepsy and helminth infection, but a causal relationship is not established in many helminths, except perhaps with neurocysticercosis. The aim of this review is to reveal details of specific mechanisms of the general helminths' impact on the nervous system and the endocrine control level of physiological functions of the host organism. Finally, we discuss the current gaps in knowledge about the interaction between helminths, immunity, and human endocrine system. Key words: helminths, immunity, hormones, cytokines.
[Mh] Termos MeSH primário: Sistema Endócrino/imunologia
Epilepsia/imunologia
Interações Hospedeiro-Parasita/imunologia
Sistema Nervoso/imunologia
Neurocisticercose/imunologia
[Mh] Termos MeSH secundário: Animais
Citocinas/imunologia
Citocinas/metabolismo
Sistema Endócrino/metabolismo
Sistema Endócrino/parasitologia
Epilepsia/complicações
Epilepsia/metabolismo
Epilepsia/parasitologia
Helmintos/patogenicidade
Helmintos/fisiologia
Hormônios/imunologia
Hormônios/metabolismo
Seres Humanos
Imunidade Inata
Sistema Nervoso/metabolismo
Sistema Nervoso/parasitologia
Neurocisticercose/complicações
Neurocisticercose/metabolismo
Neurocisticercose/parasitologia
Transdução de Sinais
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Cytokines); 0 (Hormones)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180207
[St] Status:MEDLINE


  2 / 3640 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:29215225
[Au] Autor:Smirnov LP; Borvinskaya EV; Suhovskaya IV
[Ti] Título:[THE SYSTEM OF XENOBIOTICS BIOTRANSFORMATION OF HELMINTHS. RESEMBLANCE AND DIFFERENSES FROM SIMILAR HOST SYSTEMS (REWEW)].
[So] Source:Parazitologiia;50(6):432-45, 2016 Nov-Dec.
[Is] ISSN:0031-1847
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:The three phases system xenobiotic biotransformation in cells as prokaryotes as eukaryotes was formed during the process of evolution. Clear and managed function of all three links of this system guarantee the survival of living organisms at alteration of chemical component of environment. Oxidation, reduction or hydrolysis of xenobiotics realize in phase I by insertion or opening reactive and hydrophilic groups in structure of drug molecule. In phase II xenobiotics or their metabolites from phase I conjugate with endogenic compounds, main of there are glutathione, glucuronic acid, amino acids and sulphates. Active transport of substrata, metabolites and conjugates through cell lipid membranes special transport proteins carry out (phase III). The system of xenobiotics biotransformation of helminths has essential differences from the same of vertebrate hosts. In particular, parasites do not reveal the activity of prime oxidases of phase I, such as CYP or FMO, in spite of the genes of these enzymes in DNA. As this phenomenon displays mainly in adult helminths, living in guts of vertebrates, then the hypothesis was formulated that this effect is related with adaptation to conditions of strong deficiency of oxygen, arise in a process of evolution (Kotze et al., 2006). Literature data testify the existence in helminths of unique forms of enzymes of phase II, the investigation of which present doubtless interest in relation with possible role in adaptation to parasitic mode of life. Notwithstanding that many of helminths GST in greater or lesser degree similar with enzymes of M, P, S and О classes of other organisms, nevertheless they have essential structural differences as compared with enzymes of hosts that makes perspective the search of specific anthelminthics vaccines. Transport of xenobiotics is now considered phase III of biotransformation. It was shown that proteins of this phase (ATP binding cassette transporters (ABC ) of parasites) play a key role in efflux of lipophilic xenobiotics, hydrophilic metabolites and conjugates and take part in forming of anthelminthics resistance. Some of these transporters, such as P-glycoprotein (Pgp), are important for drug resistance of helminths. In particular, a correlation between the level of expression of Pgp and resistance of S. mansoni and F. hepatica to widely used anthelminthics as praziquantel and triclabendazol exist.
[Mh] Termos MeSH primário: Helmintos/metabolismo
Xenobióticos/metabolismo
[Mh] Termos MeSH secundário: Animais
Biotransformação/fisiologia
Helmintos/genética
Especificidade da Espécie
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Xenobiotics)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171221
[Lr] Data última revisão:
171221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171208
[St] Status:MEDLINE


  3 / 3640 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29095820
[Au] Autor:Marzano V; Mancinelli L; Bracaglia G; Del Chierico F; Vernocchi P; Di Girolamo F; Garrone S; Tchidjou Kuekou H; D'Argenio P; Dallapiccola B; Urbani A; Putignani L
[Ad] Endereço:Human Microbiome Unit, Bambino Gesù Children's Hospital IRCCS, Rome, Italy.
[Ti] Título:"Omic" investigations of protozoa and worms for a deeper understanding of the human gut "parasitome".
[So] Source:PLoS Negl Trop Dis;11(11):e0005916, 2017 Nov.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The human gut has been continuously exposed to a broad spectrum of intestinal organisms, including viruses, bacteria, fungi, and parasites (protozoa and worms), over millions of years of coevolution, and plays a central role in human health. The modern lifestyles of Western countries, such as the adoption of highly hygienic habits, the extensive use of antimicrobial drugs, and increasing globalisation, have dramatically altered the composition of the gut milieu, especially in terms of its eukaryotic "citizens." In the past few decades, numerous studies have highlighted the composition and role of human intestinal bacteria in physiological and pathological conditions, while few investigations exist on gut parasites and particularly on their coexistence and interaction with the intestinal microbiota. Studies of the gut "parasitome" through "omic" technologies, such as (meta)genomics, transcriptomics, proteomics, and metabolomics, are herein reviewed to better understand their role in the relationships between intestinal parasites, host, and resident prokaryotes, whether pathogens or commensals. Systems biology-based profiles of the gut "parasitome" under physiological and severe disease conditions can indeed contribute to the control of infectious diseases and offer a new perspective of omics-assisted tropical medicine.
[Mh] Termos MeSH primário: Trato Gastrointestinal/parasitologia
Genômica
Interações Hospedeiro-Parasita
Metabolômica
Parasitos/fisiologia
Proteômica
[Mh] Termos MeSH secundário: Animais
Entamoeba histolytica/genética
Entamoeba histolytica/metabolismo
Microbioma Gastrointestinal
Giardia/genética
Giardia/metabolismo
Helmintos/genética
Helmintos/fisiologia
Seres Humanos
Camundongos
Taenia solium/genética
Taenia solium/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171119
[Lr] Data última revisão:
171119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171103
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0005916


  4 / 3640 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28947636
[Au] Autor:Moser W; Schindler C; Keiser J
[Ad] Endereço:Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, PO Box, CH-4002 Basel, Switzerland.
[Ti] Título:Efficacy of recommended drugs against soil transmitted helminths: systematic review and network meta-analysis.
[So] Source:BMJ;358:j4307, 2017 Sep 25.
[Is] ISSN:1756-1833
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo: To evaluate efficacies of anthelmintic drugs against soil transmitted helminths in terms of cure rates and egg reduction rates. Systematic review and network meta-analysis. PubMed, ISI Web of Science, Embase, ScienceDirect, the Cochrane Central Register of Clinical Trials, and the World Health Organization library database from 1960 until 31 December 2016. Randomised controlled trials evaluating the efficacy of a single dose regimen of albendazole, mebendazole, levamisole, and pyrantel pamoate against , hookworm ( and ) and The primary outcomes included cure rates analysed by network meta-analysis with mixed logistic regression models and egg reduction rates with mixed linear models. 55 and 46 randomised controlled trials were included in the analysis of cure rates and egg reduction rates, respectively. All drugs were highly efficacious against Albendazole showed the highest efficacy against hookworm infections with a cure rate of 79.5% (95% confidence interval 71.5% to 85.6%) and an egg reduction rate of 89.6% (81.9% to 97.3%). All drugs had low efficacy against , with mebendazole showing the highest cure rate of 42.1% (25.9% to 60.2%) and egg reduction rate of 66.0% (54.6% to 77.3%). Estimates for the years 1995 and 2015 showed significant reductions in efficacy of albendazole against : by 2015 the egg reduction rates fell from 72.6% (53.7% to 91.5%) to 43.4% (23.5% to 63.3%; P=0.049) and the cure rates fell from 38.6% (26.2% to 52.7%) to 16.4 (7.7% to 31.3%; P=0.027). All four currently recommended drugs show limitations in their efficacy profile. While only albendazole showed good efficacy against hookworm infection, all drugs had low efficacy against The decrease in efficacy of albendazole against over the past two decades is of concern. The findings indicate the need for strengthening efforts to develop new drug treatments, with a particular focus on drugs against .
[Mh] Termos MeSH primário: Anti-Helmínticos/farmacologia
Helmintíase/prevenção & controle
Helmintos/efeitos dos fármacos
Solo/parasitologia
[Mh] Termos MeSH secundário: Animais
Feminino
Helmintíase/transmissão
Seres Humanos
Masculino
Metanálise em Rede
Ensaios Clínicos Controlados Aleatórios como Assunto
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; REVIEW
[Nm] Nome de substância:
0 (Anthelmintics); 0 (Soil)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170927
[St] Status:MEDLINE
[do] DOI:10.1136/bmj.j4307


  5 / 3640 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28892494
[Au] Autor:Jenkins TP; Rathnayaka Y; Perera PK; Peachey LE; Nolan MJ; Krause L; Rajakaruna RS; Cantacessi C
[Ad] Endereço:Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom.
[Ti] Título:Infections by human gastrointestinal helminths are associated with changes in faecal microbiota diversity and composition.
[So] Source:PLoS One;12(9):e0184719, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Investigations of the impact that patent infections by soil-transmitted gastrointestinal nematode parasites exert on the composition of the host gut commensal flora are attracting growing interest by the scientific community. However, information collected to date varies across experiments, and further studies are needed to identify consistent relationships between parasites and commensal microbial species. Here, we explore the qualitative and quantitative differences between the microbial community profiles of cohorts of human volunteers from Sri Lanka with patent infection by one or more parasitic nematode species (H+), as well as that of uninfected subjects (H-) and of volunteers who had been subjected to regular prophylactic anthelmintic treatment (Ht). High-throughput sequencing of the bacterial 16S rRNA gene, followed by bioinformatics and biostatistical analyses of sequence data revealed no significant differences in alpha diversity (Shannon) and richness between groups (P = 0.65, P = 0.13 respectively); however, beta diversity was significantly increased in H+ and Ht when individually compared to H-volunteers (P = 0.04). Among others, bacteria of the families Verrucomicrobiaceae and Enterobacteriaceae showed a trend towards increased abundance in H+, whereas the Leuconostocaceae and Bacteroidaceae showed a relative increase in H- and Ht respectively. Our findings add valuable knowledge to the vast, and yet little explored, research field of parasite-microbiota interactions and will provide a basis for the elucidation of the role such interactions play in pathogenic and immune-modulatory properties of parasitic nematodes in both human and animal hosts.
[Mh] Termos MeSH primário: Biodiversidade
Fezes/microbiologia
Microbioma Gastrointestinal
Helmintíase/microbiologia
Helmintíase/parasitologia
Helmintos
Enteropatias Parasitárias/microbiologia
[Mh] Termos MeSH secundário: Análise de Variância
Animais
Biologia Computacional/métodos
Seres Humanos
Metagenoma
Metagenômica/métodos
Sri Lanka
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171018
[Lr] Data última revisão:
171018
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170912
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0184719


  6 / 3640 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28853206
[Au] Autor:Inocencio da Luz R; Linsuke S; Lutumba P; Hasker E; Boelaert M
[Ad] Endereço:Department of Public Health, Institute of Tropical Medicine Antwerp, Antwerp, Belgium.
[Ti] Título:Assessment of schistosomiasis and soil-transmitted helminths prevalence in school-aged children and opportunities for integration of control in local health services in Kwilu Province, the Democratic Republic of the Congo.
[So] Source:Trop Med Int Health;22(11):1442-1450, 2017 Nov.
[Is] ISSN:1365-3156
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To determine the prevalence of schistosomiasis (SCH) and soil-transmitted helminths (STH) in the Democratic Republic of Congo, and to assess the capacity of the local health centres for diagnosis and treatment. METHODS: Cross-sectional school-based survey in two health districts in the Province of Kwilu. We collected a stool and a urine sample for parasitological examination. Urine filtration and duplicate Kato-Katz thick smears were used for the diagnosis of SCH. Health centres were evaluated using a structured questionnaire. RESULTS: In total, 526 children participated in the study and the overall prevalence of Schistosoma mansoni infection was 8.9% (95% CI: 3.5-13.2) in both districts. The prevalence was higher in Mosango (11.7%; 95% CI: 8.9-14.8) than Yasa Bonga district (6.2%; 95% CI: 1.1-11.4). Urine filtration showed that Schistosoma haematobium infection was not present. The combined STH infection prevalence was 58.1% in both districts; hookworm infection was the most common STH found in 52.9% (95% CI: 29.3-62.4) of subjects, followed by Ascaris lumbricoides 9.3% (95% CI: 5.8-15.5) and Trichuris trichiura 2.1% (95% CI: 0.9-4.9). Mixed STH infections were observed as well as SCH-STH coinfection. CONCLUSION: Further mapping of both SCH and STH burden is needed, and coverage of preventive chemotherapy in school-aged children should be increased.
[Mh] Termos MeSH primário: Coinfecção/prevenção & controle
Serviços de Saúde
Helmintíase/prevenção & controle
Helmintos/crescimento & desenvolvimento
Enteropatias Parasitárias/prevenção & controle
Solo/parasitologia
[Mh] Termos MeSH secundário: Animais
Ascaríase/epidemiologia
Ascaríase/prevenção & controle
Ascaris lumbricoides
Criança
Coinfecção/epidemiologia
Estudos Transversais
República Democrática do Congo/epidemiologia
Feminino
Helmintíase/epidemiologia
Seres Humanos
Enteropatias Parasitárias/epidemiologia
Masculino
Prevalência
Schistosoma haematobium
Schistosoma mansoni
Esquistossomose Urinária/epidemiologia
Esquistossomose Urinária/prevenção & controle
Esquistossomose mansoni/epidemiologia
Esquistossomose mansoni/prevenção & controle
Instituições Acadêmicas
Tricuríase/epidemiologia
Tricuríase/prevenção & controle
Trichuris
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Soil)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170831
[St] Status:MEDLINE
[do] DOI:10.1111/tmi.12965


  7 / 3640 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28819509
[Au] Autor:Tefera E; Belay T; Mekonnen SK; Zeynudin A; Belachew T
[Ad] Endereço:Department of Medical Laboratory Sciences, College of Health and Medical Sciences, Haramaya University, Harar, Ethiopia.
[Ti] Título:Prevalence and intensity of soil transmitted helminths among school children of Mendera Elementary School, Jimma, Southwest Ethiopia.
[So] Source:Pan Afr Med J;27:88, 2017.
[Is] ISSN:1937-8688
[Cp] País de publicação:Uganda
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Soil transmitted helminths are wide spread in developing countries and in Ethiopia the prevalence of STHs varies in different parts of the country. The aim of this study was to determine the prevalence and intensity of soil transmitted helminths among school children of Mendera Elementary School Jimma town, Southwestern Ethiopia. METHODS: A cross-sectional study was conducted between March 29 and April 9, 2010 to determine the prevalence and intensity of soil transmitted helminths among elementary school children. The study participants were randomly selected from class enrollment list after proportional allocation of the total sample size to each grade. Data about the background characteristics were collected using structured questionnaire. The stool samples were examined by McMaster method for the egg count which was used to determine intensity of infection. Data were analyzed using SPSS for windows version 16 and p-value less than 5% was considered as statistically significant. RESULTS: Of the total 715 stool specimens examined, 346 were positive for at least one intestinal parasite making the prevalence 48.4%. The most prevalent parasites were Ascaris 169 (23.6%) and 165 (23.1%). The prevalence of soil transmitted helminth in this study was 45.6% (326/715). There was statistically significant difference in the prevalence of Trichuriasis between those who use latrine always and who use sometimes (p = 0.010). Females are two times more likely to be positive for Ascaris than males (p = 0.039). Majority of the students had light infection of soil transmitted helminths and none of them had heavy intensity of infection of Trichuriasis and hookworms. CONCLUSION: Nearly half of the school children were infected with at least one STHs and majority of the students had light infection of soil transmitted helminths. Students who did not wash their hands after defecation were three times more likely to be positive for Ascaris infection than those who washed their hands after defecation. Therefore, measures like health information dissemination on the advantage of washing hands after defecation and on proper use of latrine should be taken into account to alleviate the problem.
[Mh] Termos MeSH primário: Desinfecção das Mãos
Helmintíase/epidemiologia
Helmintos/isolamento & purificação
Solo/parasitologia
[Mh] Termos MeSH secundário: Adolescente
Animais
Criança
Pré-Escolar
Estudos Transversais
Etiópia/epidemiologia
Feminino
Helmintíase/parasitologia
Seres Humanos
Masculino
Prevalência
Distribuição por Sexo
Estudantes
Inquéritos e Questionários
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Soil)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170819
[St] Status:MEDLINE
[do] DOI:10.11604/pamj.2017.27.88.8817


  8 / 3640 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28798236
[Au] Autor:Amireddy N; Puttapaka SN; Vinnakota RL; Ravuri HG; Thonda S; Kalivendi SV
[Ad] Endereço:From the Centre for Chemical Biology and.
[Ti] Título:The unintended mitochondrial uncoupling effects of the FDA-approved anti-helminth drug nitazoxanide mitigates experimental parkinsonism in mice.
[So] Source:J Biol Chem;292(38):15731-15743, 2017 Sep 22.
[Is] ISSN:1083-351X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Mitochondria play a primary role in the pathophysiology of Parkinson's disease (PD), and small molecules that counteract the initial stages of disease may offer therapeutic benefit. In this regard, we have examined whether the off-target effects of the Food and Drug Administration (FDA)-approved anti-helminth drug nitazoxanide (NTZ) on mitochondrial respiration could possess any therapeutic potential for PD. Results indicate that MPP -induced loss in oxygen consumption rate (OCR) and ATP production by mitochondria were ameliorated by NTZ in real time by virtue of its mild uncoupling effect. Pretreatment of cells with NTZ mitigated MPP -induced loss in mitochondrial OCR and reactive oxygen species (ROS). Similarly, addition of NTZ to cells pretreated with MPP could reverse block in mitochondrial OCR and reactive oxygen species induced by MPP in real time. The observed effects of NTZ were found to be transient and reversible as removal of NTZ from incubation medium restored the mitochondrial respiration to that of controls. Apoptosis induced by MPP was ameliorated by NTZ in a dose-dependent manner. results demonstrated that oral administration of NTZ (50 mg/kg) in an acute MPTP mouse model of PD conferred significant protection against the loss of tyrosine hydroxylase (TH)-positive neurons of substantia nigra. Based on the above observations we believe that repurposing of NTZ for PD may offer therapeutic benefit.
[Mh] Termos MeSH primário: Aprovação de Drogas
Helmintos/efeitos dos fármacos
Mitocôndrias/efeitos dos fármacos
Mitocôndrias/metabolismo
Transtornos Parkinsonianos/tratamento farmacológico
Tiazóis/farmacologia
United States Food and Drug Administration
[Mh] Termos MeSH secundário: Trifosfato de Adenosina/biossíntese
Animais
Apoptose/efeitos dos fármacos
Linhagem Celular Tumoral
Respiração Celular/efeitos dos fármacos
Seres Humanos
Masculino
Potencial da Membrana Mitocondrial/efeitos dos fármacos
Camundongos
Neurônios/efeitos dos fármacos
Neurônios/patologia
Transtornos Parkinsonianos/metabolismo
Transtornos Parkinsonianos/patologia
Ratos
Espécies Reativas de Oxigênio/metabolismo
Tiazóis/uso terapêutico
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Reactive Oxygen Species); 0 (Thiazoles); 8L70Q75FXE (Adenosine Triphosphate); SOA12P041N (nitazoxanide)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171009
[Lr] Data última revisão:
171009
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170812
[St] Status:MEDLINE
[do] DOI:10.1074/jbc.M117.791863


  9 / 3640 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28767699
[Au] Autor:Gaur U; Tu J; Li D; Gao Y; Lian T; Sun B; Yang D; Fan X; Yang M
[Ad] Endereço:Institute of Animal Genetics and Breeding, Sichuan Agricultural University, Chengdu, Sichuan, P. R. China.
[Ti] Título:Molecular evolutionary patterns of NAD+/Sirtuin aging signaling pathway across taxa.
[So] Source:PLoS One;12(8):e0182306, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A deeper understanding of the conserved molecular mechanisms in different taxa have been made possible only because of the evolutionary conservation of crucial signaling pathways. In the present study, we explored the molecular evolutionary pattern of selection signatures in 51 species for 10 genes which are important components of NAD+/Sirtuin pathway and have already been directly linked to lifespan extension in worms and mice. Selection pressure analysis using PAML program revealed that MRPS5 and PPARGC1A were under significant constraints because of their functional significance. FOXO3a also displayed strong purifying selection. All three sirtuins, which were SIRT1, SIRT2 and SIRT6, displayed a great degree of conservation between taxa, which is consistent with the previous report. A significant evolutionary constraint is seen on the anti-oxidant gene, SOD3. As expected, TP53 gene was under significant selection pressure in mammals, owing to its major role in tumor progression. Poly-ADP-ribose polymerase (PARP) genes displayed the most sites under positive selection. Further 3D structural analysis of PARP1 and PARP2 protein revealed that some of these positively selected sites caused a change in the electrostatic potential of the protein structure, which may allow a change in its interaction with other proteins and molecules ultimately leading to difference in the function. Although the functional significance of the positively selected sites could not be established in the variants databases, yet it will be interesting to see if these sites actually affect the function of PARP1 and PARP2.
[Mh] Termos MeSH primário: Envelhecimento/metabolismo
Helmintos/fisiologia
NAD/metabolismo
Sirtuínas/metabolismo
[Mh] Termos MeSH secundário: Animais
Evolução Molecular
Seres Humanos
Camundongos
Poli(ADP-Ribose) Polimerase-1/química
Poli(ADP-Ribose) Polimerases/química
Seleção Genética
Transdução de Sinais
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0U46U6E8UK (NAD); EC 2.4.2.30 (Poly (ADP-Ribose) Polymerase-1); EC 2.4.2.30 (Poly(ADP-ribose) Polymerases); EC 3.5.1.- (Sirtuins)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170929
[Lr] Data última revisão:
170929
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170803
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0182306


  10 / 3640 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28759590
[Au] Autor:Amelio P; Portevin D; Reither K; Mhimbira F; Mpina M; Tumbo A; Nickel B; Marti H; Knopp S; Ding S; Penn-Nicholson A; Darboe F; Ohmiti K; Scriba TJ; Pantaleo G; Daubenberger C; Perreau M
[Ad] Endereço:Service of Immunology and Allergy, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland.
[Ti] Título:Mixed Th1 and Th2 Mycobacterium tuberculosis-specific CD4 T cell responses in patients with active pulmonary tuberculosis from Tanzania.
[So] Source:PLoS Negl Trop Dis;11(7):e0005817, 2017 Jul.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Mycobacterium tuberculosis (Mtb) and helminth infections elicit antagonistic immune effector functions and are co-endemic in several regions of the world. We therefore hypothesized that helminth infection may influence Mtb-specific T-cell immune responses. We evaluated the cytokine profile of Mtb-specific T cells in 72 individuals with pulmonary TB disease recruited from two Sub-Saharan regions with high and moderate helminth burden i.e. 55 from Tanzania (TZ) and 17 from South Africa (SA), respectively. We showed that Mtb-specific CD4 T-cell functional profile of TB patients from Tanzania are primarily composed of polyfunctional Th1 and Th2 cells, associated with increased expression of Gata-3 and reduced expression of T-bet in memory CD4 T cells. In contrast, the cytokine profile of Mtb-specific CD4 T cells of TB patients from SA was dominated by single IFN-γ and dual IFN-γ/TNF-α and associated with TB-induced systemic inflammation and elevated serum levels of type I IFNs. Of note, the proportion of patients with Mtb-specific CD8 T cells was significantly reduced in Mtb/helminth co-infected patients from TZ. It is likely that the underlying helminth infection and possibly genetic and other unknown environmental factors may have caused the induction of mixed Th1/Th2 Mtb-specific CD4 T cell responses in patients from TZ. Taken together, these results indicate that the generation of Mtb-specific CD4 and CD8 T cell responses may be substantially influenced by environmental factors in vivo. These observations may have major impact in the identification of immune biomarkers of disease status and correlates of protection.
[Mh] Termos MeSH primário: Linfócitos T CD4-Positivos/imunologia
Helmintíase/imunologia
Equilíbrio Th1-Th2
Tuberculose Pulmonar/imunologia
[Mh] Termos MeSH secundário: Adulto
Animais
Coinfecção/imunologia
Feminino
Helmintos/isolamento & purificação
Seres Humanos
Interferon gama/sangue
Masculino
Mycobacterium tuberculosis
África do Sul
Tanzânia
Fator de Necrose Tumoral alfa/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Tumor Necrosis Factor-alpha); 82115-62-6 (Interferon-gamma)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170827
[Lr] Data última revisão:
170827
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170801
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0005817



página 1 de 364 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde