[PMID]: | 21254932 |
[Au] Autor: | Richardson DJ; Brink CD |
[Ad] Endereço: | Department of Biological Sciences, Quinnipiac University, Hamden, Connecticut 06518, USA. dennis.richardson@quinnipiac.edu |
[Ti] Título: | Effectiveness of various anthelmintics in the treatment of moniliformiasis in experimentally infected Wistar rats. |
[So] Source: | Vector Borne Zoonotic Dis;11(8):1151-6, 2011 Aug. |
[Is] ISSN: | 1557-7759 |
[Cp] País de publicação: | United States |
[La] Idioma: | eng |
[Ab] Resumo: | Humans occasionally become infected with acanthocephalans, particularly Moniliformis moniliformis. Although several anthelmintics have been used, no controlled studies have been conducted to assess the efficacy of common anthelmintics in the treatment of moniliformiasis. The effectiveness of pyrantel pamoate, ivermectin, praziquantel, niclosamide, thiabendazole, and mebendazole was evaluated in the treatment of moniliformiasis in laboratory-infected female Wistar rats. Pyrantel pamoate and ivermectin were wholly unsuccessful in the treatment of moniliformiasis. A single dose of thiabendazole lead to a 40% reduction and two doses lead to a 57% reduction of worm burden after 2 weeks. The most effective drug in the treatment of moniliformiasis in rats was mebendazole, for which two doses resulted in a 69% reduction in worm burden after 2 weeks; however, 50% of the rats receiving the treatment died within 2 weeks after first administration of the drug. Two surviving rats that had been treated with mebendazole exhibited evidence of hepatic dysfunction characterized by extremely elevated levels of alkaline phosphatase in conjuction with depressed serum albumin levels. It is hypothesized that Mo. moniliformis may metabolize the drug and release a metabolite that is highly toxic to the host. On the basis of these data, thiabendazole is recommended as the drug of choice for the treatment of human acanthocephaliasis until more extensive testing can be conducted. |
[Mh] Termos MeSH primário: |
Anti-Helmínticos/farmacologia Anti-Helmínticos/normas Helmintíase/tratamento farmacológico Moniliformis/efeitos dos fármacos
|
[Mh] Termos MeSH secundário: |
Animais Baratas/parasitologia Modelos Animais de Doenças Feminino Mebendazol/farmacologia Mebendazol/normas Moniliformis/crescimento & desenvolvimento Ratos Ratos Wistar Tiabendazol/farmacologia Tiabendazol/normas
|
[Pt] Tipo de publicação: | COMPARATIVE STUDY; EVALUATION STUDIES; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T |
[Nm] Nome de substância:
| 0 (Anthelmintics); 81G6I5V05I (Mebendazole); N1Q45E87DT (Thiabendazole) |
[Em] Mês de entrada: | 1202 |
[Cu] Atualização por classe: | 131121 |
[Lr] Data última revisão:
| 131121 |
[Sb] Subgrupo de revista: | IM |
[Da] Data de entrada para processamento: | 110125 |
[St] Status: | MEDLINE |
[do] DOI: | 10.1089/vbz.2010.0151 |
|
|