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  1 / 1956 MEDLINE  
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[PMID]:28683055
[Au] Autor:Springer YP; Casillas S; Helfrich K; Mocan D; Smith M; Arriaga G; Mixson L; Castrodale L; McLaughlin J
[Ti] Título:Two Outbreaks of Trichinellosis Linked to Consumption of Walrus Meat - Alaska, 2016-2017.
[So] Source:MMWR Morb Mortal Wkly Rep;66(26):692-696, 2017 Jul 07.
[Is] ISSN:1545-861X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:During 1975-2012, CDC surveillance identified 1,680 trichinellosis cases in the United States with implicated food items; among these cases, 1,219 were attributed to consumption of raw or pork products, and 461 were attributed to nonpork products. Although trichinellosis in the United States has historically been associated with consumption of pork, multiple nonporcine species of wild game also are competent hosts for Trichinella spp. and have been collectively implicated in the majority of trichinellosis cases since the late 1990s (1-4) (Figure 1). During July 2016-May 2017, the Alaska Division of Public Health (ADPH) investigated two outbreaks of trichinellosis in the Norton Sound region associated with consumption of raw or undercooked walrus (Odobenus rosmarus) meat; five cases were identified in each of the two outbreaks. These were the first multiple-case outbreaks of walrus-associated trichinellosis in Alaska since 1992 (Figure 2). Health care providers should inquire about consumption of commercially prepared and personally harvested meats when evaluating suspected trichinellosis cases, especially in areas where consumption of wild game is commonplace.
[Mh] Termos MeSH primário: Surtos de Doenças
Parasitologia de Alimentos
Carne/parasitologia
Triquinelose/epidemiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Alaska/epidemiologia
Animais
Feminino
Seres Humanos
Masculino
Trichinella/isolamento & purificação
Triquinelose/diagnóstico
Morsas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170713
[Lr] Data última revisão:
170713
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170707
[St] Status:MEDLINE
[do] DOI:10.15585/mmwr.mm6626a3


  2 / 1956 MEDLINE  
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[PMID]:28665952
[Au] Autor:Lovera R; Fernández MS; Jacob J; Lucero N; Morici G; Brihuega B; Farace MI; Caracostantogolo J; Cavia R
[Ad] Endereço:Departamento de Ecología, Genética y Evolución, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires and Instituto de Ecología, Genética y Evolución de Buenos Aires (IEGEBA), UBA-CONICET, Cdad. Autónoma de Buenos Aires, Argentina.
[Ti] Título:Intrinsic and extrinsic factors related to pathogen infection in wild small mammals in intensive milk cattle and swine production systems.
[So] Source:PLoS Negl Trop Dis;11(6):e0005722, 2017 Jun.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Understanding the ecological processes that are involved in the transmission of zoonotic pathogens by small mammals may aid adequate and effective management measures. Few attempts have been made to analyze the ecological aspects that influence pathogen infection in small mammals in livestock production systems. We describe the infection of small mammals with Leptospira spp., Brucella spp., Trichinella spp. and Cysticercus fasciolaris and assess the related intrinsic and extrinsic factors in livestock production systems in central Argentina at the small mammal community, population and individual levels. METHODOLOGY/PRINCIPAL FINDINGS: Ten pig farms and eight dairy farms were studied by removal trapping of small mammals from 2008 to 2011. Each farm was sampled seasonally over the course of one year with cage and Sherman live traps. The 505 small mammals captured (14,359 trap-nights) included three introduced murine rodents, four native rodents and two opossums. Leptospira spp., anti-Brucella spp. antibodies and Trichinella spp. were found in the three murine rodents and both opossums. Rattus norvegicus was also infected with C. fasciolaris; Akodon azarae and Oligoryzomys flavescens with Leptospira spp.; anti-Brucella spp. antibodies were found in A. azarae. Two or more pathogens occurred simultaneously on 89% of the farms, and each pathogen was found on at least 50% of the farms. Pathogen infections increased with host abundance. Infection by Leptospira spp. also increased with precipitation and during warm seasons. The occurrence of anti-Brucella spp. antibodies was higher on dairy farms and during the winter and summer. The host abundances limit values, from which farms are expected to be free of the studied pathogens, are reported. CONCLUSIONS/SIGNIFICANCE: Murine rodents maintain pathogens within farms, whereas other native species are likely dispersing pathogens among farms. Hence, we recommend preventing and controlling murines in farm dwellings and isolating farms from their surroundings to avoid contact with other wild mammals.
[Mh] Termos MeSH primário: Infecções Bacterianas/veterinária
Gambás/microbiologia
Gambás/parasitologia
Doenças Parasitárias em Animais/epidemiologia
Roedores/microbiologia
Roedores/parasitologia
[Mh] Termos MeSH secundário: Animais
Anticorpos Antibacterianos/sangue
Argentina
Infecções Bacterianas/epidemiologia
Brucella/imunologia
Bovinos
Fazendas
Leptospira/isolamento & purificação
Prevalência
Suínos
Taenia/isolamento & purificação
Trichinella/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Bacterial)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170808
[Lr] Data última revisão:
170808
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170701
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0005722


  3 / 1956 MEDLINE  
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[PMID]:28439686
[Au] Autor:Bilska-Zajac E; Rózycki M; Chmurzynska E; Antolak E; Próchniak M; Gradziel-Krukowska K; Karamon J; Sroka J; Zdybel J; Cencek T
[Ad] Endereço:National Veterinary Research Institute in Pulawy, Partyzantów Avenue 57, 24-100, Pulawy, Poland. ewa.bilska@piwet.pulawy.pl.
[Ti] Título:First case of Trichinella nativa infection in wild boar in Central Europe-molecular characterization of the parasite.
[So] Source:Parasitol Res;116(6):1705-1711, 2017 Jun.
[Is] ISSN:1432-1955
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The examination of wild boars gained in Poland shows for the first time occurrence of Trichinella nativa, freeze-resistant species of Trichinella in this host from the central Europe region. This finding is not only one of several cases of T. nativa invasion in wild boars all over the world but also one of the very few cases of T. nativa detected so far beyond the known boundary of occurrence of this species. The molecular characterization of discovered larvae based on analysis of partial genes: 5s rDNA-ISR and CO1 confirm the findings. Moreover, the analyzed DNA sequences of both genes present new haplotypes of T. nativa in comparison to that described previously.
[Mh] Termos MeSH primário: Sus scrofa/parasitologia
Trichinella/isolamento & purificação
Triquinelose/veterinária
[Mh] Termos MeSH secundário: Animais
DNA de Helmintos/genética
Haplótipos
Larva/genética
Polônia/epidemiologia
Suínos
Trichinella/genética
Triquinelose/epidemiologia
Triquinelose/parasitologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Helminth)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171025
[Lr] Data última revisão:
171025
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170426
[St] Status:MEDLINE
[do] DOI:10.1007/s00436-017-5446-6


  4 / 1956 MEDLINE  
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[PMID]:28438521
[Au] Autor:Taher EE; Méabed EMH; El Akkad DMH; Kamel NO; Sabry MA
[Ad] Endereço:Department of Parasitology, Research Institute of Ophthalmology, El-Giza, Egypt.
[Ti] Título:Modified dot-ELISA for diagnosis of human trichinellosis.
[So] Source:Exp Parasitol;177:40-46, 2017 Jun.
[Is] ISSN:1090-2449
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This study aimed to modify Dot-Enzyme-linked immunosorbent assay (dot-ELISA) for the diagnosis of human trichinellosis and to compare its performance with indirect ELISA and Western-blot assay (EITB). A total of 175 human serum samples were enrolled in the study. Indirect ELISA was used for the primary diagnosis. EITB versus fractionated 1st larval stage excretory-secretory antigens (TL-1 ESA) revealed three specific protein fractions at MW of 45, 50, and 55 kDa (kDa). Dot-ELISA was performed in two ways. In the first one, sera were dotted on the separated three specific protein fractions, while in the second one the three fractions were eluted, concentrated at one pooled antigen that used in classic dot-ELISA. Both types of dot-ELISA proved absolute (100%) sensitivity and specificity in comparison with the gold standard EITB reaction. While sensitivity of ELISA was 100% and its specificity was 79.5%. The fraction at 45 kDa was the most sensitive one. The use of the pooled antigen improved the test results. The described dot-ELISA is an easy applicable diagnostic tool gathering the benefits of both ELISA and EITB.
[Mh] Termos MeSH primário: Ensaio de Imunoadsorção Enzimática/métodos
Trichinella/isolamento & purificação
Triquinelose/diagnóstico
[Mh] Termos MeSH secundário: Animais
Anticorpos Anti-Helmínticos/sangue
Área Sob a Curva
Western Blotting
Estudos de Casos e Controles
Reações Cruzadas
Eletroforese em Gel de Poliacrilamida
Feminino
Seres Humanos
Larva
Masculino
Músculos/parasitologia
Curva ROC
Sensibilidade e Especificidade
Suínos
Trichinella/imunologia
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Helminth)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170620
[Lr] Data última revisão:
170620
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170426
[St] Status:MEDLINE


  5 / 1956 MEDLINE  
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[PMID]:28213036
[Au] Autor:Rostami A; Gamble HR; Dupouy-Camet J; Khazan H; Bruschi F
[Ad] Endereço:Department of Parasitology and Mycology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Students Research Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: Alirostami1984@gmail.com.
[Ti] Título:Meat sources of infection for outbreaks of human trichinellosis.
[So] Source:Food Microbiol;64:65-71, 2017 Jun.
[Is] ISSN:1095-9998
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Trichinellosis is one of the most important foodborne zoonotic diseases, with worldwide distribution. While human risk for trichinellosis has historically been linked to pork, modern pork production systems and slaughter inspection programs have reduced or eliminated pork as a source for trichinellosis in many countries. While pork may no longer pose a significant risk for trichinellosis, many other animal species may be hosts for Trichinella species nematodes and when human consume meat from these animal species, there may be risk for acquiring trichinellosis. This review article describes the various non-pork meat sources of human trichinellosis outbreaks, where these outbreaks have occurred and some of the factors that contribute to human risk. The literature reviewed here provides evidence of the persistence of Trichinella as a human health risk for people who eat meat from feral and wild carnivores and scavengers, as well as some herbivores that have been shown to harbor Trichinella larvae. It points to the importance of education of hunters and consumers of these meats and meat products.
[Mh] Termos MeSH primário: Surtos de Doenças
Produtos da Carne/parasitologia
Carne/parasitologia
Triquinelose/transmissão
[Mh] Termos MeSH secundário: Animais
Animais Selvagens/parasitologia
Cervos/parasitologia
Surtos de Doenças/prevenção & controle
Europa (Continente)/epidemiologia
Inocuidade dos Alimentos
Cavalos/microbiologia
Seres Humanos
Sus scrofa/parasitologia
Trichinella/isolamento & purificação
Triquinelose/epidemiologia
Triquinelose/parasitologia
Triquinelose/prevenção & controle
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170314
[Lr] Data última revisão:
170314
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170219
[St] Status:MEDLINE


  6 / 1956 MEDLINE  
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[PMID]:28130490
[Au] Autor:Sato A; Suematsu T; Aihara KK; Kita K; Suzuki T; Watanabe K; Ohtsuki T; Watanabe YI
[Ad] Endereço:Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa, Chiba 277-8562, Japan.
[Ti] Título:Duplication of mitochondrial EF-Tu: pre-adaptation to T-arm truncation and exclusion of bulky aminoacyl residues.
[So] Source:Biochem J;474(6):957-969, 2017 Mar 07.
[Is] ISSN:1470-8728
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Translation elongation factor Tu (EF-Tu) delivers aminoacyl-tRNA (aa-tRNA) to ribosomes in protein synthesis. EF-Tu generally recognizes aminoacyl moieties and acceptor- and T-stems of aa-tRNAs. However, nematode mitochondrial (mt) tRNAs frequently lack all or part of the T-arm that is recognized by canonical EF-Tu. We previously reported that two distinct EF-Tu species, EF-Tu1 and EF-Tu2, respectively, recognize mt tRNAs lacking T-arms and D-arms in the mitochondria of the chromadorean nematode EF-Tu2 specifically recognizes the seryl moiety of serylated D-armless tRNAs. Mitochondria of the enoplean nematode possess three structural types of tRNAs: T-armless tRNAs, D-armless tRNAs, and cloverleaf tRNAs with a short T-arm. mt EF-Tu1 binds to all three types and EF-Tu2 binds only to D-armless Ser-tRNAs, showing an evolutionary intermediate state from canonical EF-Tu to chromadorean nematode (e.g. ) EF-Tu species. We report here that two EF-Tu species also participate in mitochondria. Both EF-Tu1 and EF-Tu2 bound to cloverleaf and D-armless tRNAs. EF-Tu1 has the ability to recognize T-armless tRNAs that do not evidently exist in mitochondria, but do exist in related arthropod species. In addition, EF-Tu2 preferentially bound to aa-tRNAs carrying small amino acids, but not to aa-tRNAs carrying bulky amino acids. These results suggest that the mt translation system could be another intermediate state between the canonical and nematode mitochondria-type translation systems.
[Mh] Termos MeSH primário: Proteínas de Drosophila/química
Drosophila melanogaster/genética
Proteínas Mitocondriais/química
Fator Tu de Elongação de Peptídeos/química
Biossíntese de Proteínas
Aminoacil-RNA de Transferência/química
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Animais
Evolução Biológica
Caenorhabditis elegans/genética
Caenorhabditis elegans/metabolismo
Clonagem Molecular
Proteínas de Drosophila/genética
Proteínas de Drosophila/metabolismo
Drosophila melanogaster/metabolismo
Escherichia coli/genética
Escherichia coli/metabolismo
Regulação da Expressão Gênica
Cinética
Mitocôndrias/genética
Mitocôndrias/metabolismo
Proteínas Mitocondriais/genética
Proteínas Mitocondriais/metabolismo
Conformação de Ácido Nucleico
Fator Tu de Elongação de Peptídeos/genética
Fator Tu de Elongação de Peptídeos/metabolismo
Isoformas de Proteínas/química
Isoformas de Proteínas/genética
Isoformas de Proteínas/metabolismo
Aminoacil-RNA de Transferência/genética
Aminoacil-RNA de Transferência/metabolismo
Proteínas Recombinantes/química
Proteínas Recombinantes/genética
Proteínas Recombinantes/metabolismo
Alinhamento de Sequência
Homologia de Sequência de Aminoácidos
Especificidade da Espécie
Trichinella/genética
Trichinella/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drosophila Proteins); 0 (Mitochondrial Proteins); 0 (Protein Isoforms); 0 (RNA, Transfer, Amino Acyl); 0 (Recombinant Proteins); EC 3.6.1.- (Peptide Elongation Factor Tu)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170615
[Lr] Data última revisão:
170615
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170129
[St] Status:MEDLINE
[do] DOI:10.1042/BCJ20160929


  7 / 1956 MEDLINE  
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[PMID]:28106258
[Au] Autor:Della Bella C; Benagiano M; De Gennaro M; Gomez-Morales MA; Ludovisi A; D'Elios S; Luchi S; Pozio E; D'Elios MM; Bruschi F
[Ad] Endereço:Department of Experimental and Clinical Medicine, Università degli Studi di Firenze, Florence, Italy.
[Ti] Título:T-cell clones in human trichinellosis: Evidence for a mixed Th1/Th2 response.
[So] Source:Parasite Immunol;39(3), 2017 Mar.
[Is] ISSN:1365-3024
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In humans, studies on the cellular immune response against Trichinella are scarce. Aim of this study was to characterize the cytokine profile of T cells specific for Trichinella britovi in trichinellosis patients. Peripheral blood mononuclear cells (PBMC) were obtained from five patients involved in a trichinellosis outbreak caused by T. britovi, which occurred in 2013 in Tuscany (Italy). All the patients resulted positive for Trichinella-specific IgG, IgE and presented eosinophilia. T cells were investigated for their proliferation to excretory/secretory antigens from Trichinella spiralis muscle larvae (TsES) and for their cytokine profile. A total of 284 CD4+ and 42 CD8+ T-cell clones were obtained from the TsES-specific T-cell lines from PBMC. All T-cell clones proliferated in response to mitogen. Of the 284 CD4+ T-cell clones generated from TsES-specific T-cell lines, 135 (47%) proliferated significantly to TsES; 26% CD8+ T-cell clones showed proliferation to TsES. In the series of the 135 TsES-specific CD4+ clones, 51% expressed a Th2 profile, 30% a Th0 and 19% Th1. In the series of the 11 TsES-specific CD8+ T-cell clones, 18% were Tc2, 45% Tc0 and 36% Tc1. In human trichinellosis, the cellular immune response is, during the chronic phase, mixed Th1/Th2.
[Mh] Termos MeSH primário: Células Th1/imunologia
Células Th2/imunologia
Trichinella/imunologia
Triquinelose/imunologia
[Mh] Termos MeSH secundário: Adulto
Animais
Células Clonais/imunologia
Citocinas
Feminino
Seres Humanos
Imunidade Celular
Leucócitos Mononucleares
Masculino
Meia-Idade
Trichinella spiralis/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cytokines)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170912
[Lr] Data última revisão:
170912
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170121
[St] Status:MEDLINE
[do] DOI:10.1111/pim.12412


  8 / 1956 MEDLINE  
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[PMID]:27894908
[Au] Autor:Abou Rayia DM; Saad AE; Ashour DS; Oreiby RM
[Ad] Endereço:Department of Medical Parasitology, Faculty of Medicine, Tanta University, Egypt.
[Ti] Título:Implication of artemisinin nematocidal activity on experimental trichinellosis: In vitro and in vivo studies.
[So] Source:Parasitol Int;66(2):56-63, 2017 Apr.
[Is] ISSN:1873-0329
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Benzimidazole drugs are used for treatment of trichinellosis, but they have a limited effect against encapsulated larval stages of Trichinella spiralis. Hence, there is a considerable interest in developing new anthelmintic drugs. Our aim is to investigate the possible effect of artemisinin on T. spiralis in in vitro and in vivo studies. T. spiralis worms were isolated from infected mice and transferred to 3 culture media; group I: with no drugs, group II: contained artemisinin and group III: contained mebendazole, then they were subjected to electron microscopic study. An in vivo study was done where mice were divided into three groups; group I: infected and untreated, group II: received artemisinin and group III: received mebendazole. The efficacy of treatment was assessed by adult and total larval counts, histopathological study of the small intestinal and muscle tissues and immunohistochemical staining of cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF) in muscles. Adult worm teguments showed significant degeneration and destruction with both drugs. Also, significant reduction of total adult and larval counts occurred in treated groups in comparison to the control group. Histopathological examination of the small intestine and muscles showed marked improvement with reduction in the inflammatory infiltrates with both drugs. COX-2 and VEGF expressions were reduced in both treated groups with more reduction in the artemisinin-treated group. This study revealed that artemisinin has the potential to be an alternative drug against trichinellosis.
[Mh] Termos MeSH primário: Antinematódeos/farmacologia
Artemisininas/administração & dosagem
Artemisininas/farmacologia
Trichinella/efeitos dos fármacos
Triquinelose/tratamento farmacológico
[Mh] Termos MeSH secundário: Animais
Antinematódeos/administração & dosagem
Ciclo-Oxigenase 2/genética
Modelos Animais de Doenças
Técnicas In Vitro
Intestino Delgado/efeitos dos fármacos
Intestino Delgado/metabolismo
Intestino Delgado/parasitologia
Intestino Delgado/ultraestrutura
Larva/efeitos dos fármacos
Mebendazol/administração & dosagem
Mebendazol/farmacologia
Camundongos
Microscopia Eletrônica
Músculos/efeitos dos fármacos
Músculos/metabolismo
Músculos/parasitologia
Músculos/ultraestrutura
Miosite/tratamento farmacológico
Miosite/parasitologia
Carga Parasitária
Triquinelose/imunologia
Triquinelose/parasitologia
Triquinelose/patologia
Fator A de Crescimento do Endotélio Vascular/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antinematodal Agents); 0 (Artemisinins); 0 (Vascular Endothelial Growth Factor A); 0 (vascular endothelial growth factor A, mouse); 81G6I5V05I (Mebendazole); EC 1.14.99.- (Ptgs2 protein, mouse); EC 1.14.99.1 (Cyclooxygenase 2)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170413
[Lr] Data última revisão:
170413
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161130
[St] Status:MEDLINE


  9 / 1956 MEDLINE  
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[PMID]:27816842
[Au] Autor:Franssen F; Swart A; van der Giessen J; Havelaar A; Takumi K
[Ad] Endereço:National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands. Electronic address: frits.franssen@rivm.nl.
[Ti] Título:Parasite to patient: A quantitative risk model for Trichinella spp. in pork and wild boar meat.
[So] Source:Int J Food Microbiol;241:262-275, 2017 Jan 16.
[Is] ISSN:1879-3460
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Consumption of raw or inadequately cooked pork meat may result in trichinellosis, a human disease due to nematodes of the genus Trichinella. In many countries worldwide, individual control of pig carcasses at meat inspection is mandatory but incurs high costs in relation to absence of positive carcasses from pigs reared under controlled housing. EU regulation 2015/1375 implements an alternative risk-based approach, in view of absence of positive findings in pigs under controlled housing conditions. Moreover, Codex Alimentarius guidelines for the control of Trichinella spp. in meat of suidae have been published (CAC, 2015) and used in conjunction with the OIE terrestrial Animal health code, to provide guidance to governments and industry on risk based control measures to prevent human exposure to Trichinella spp. and to facilitate international pork trade. To further support such a risk-based approach, we model the risk of human trichinellosis due to consumption of meat from infected pigs, raised under non-controlled housing and wild boar, using Quantitative Microbial Risk Assessment (QMRA) methods. Our model quantifies the distribution of Trichinella muscle larve (ML) in swine, test sensitivity at carcass control, partitioning of edible pork parts, Trichinella ML distribution in edible muscle types, heat inactivation by cooking and portion sizes. The resulting exposure estimate is combined with a dose response model for Trichinella species to estimate the incidence of human illness after consumption of infected meat. Paramater estimation is based on experimental and observational datasets. In Poland, which served as example, we estimated an average incidence of 0.90 (95%CI: 0.00-3.68) trichinellosis cases per million persons per year (Mpy) due to consumption of pork from pigs that were reared under non-controlled housing, and 1.97 (95%CI: 0.82-4.00) cases per Mpy due to consumption of wild boar. The total estimated incidence of human trichinellosis attributed to pigs from non-controlled housing and wild boar in Poland, is similar to the incidence of human trichinellosis in that country reported by EFSA. Overall, in Europe, we estimated an upper incidence limit of 5.3×10 cases per Mpy, or less than one predicted case of trichinellosis in the European Union every 4years, due to consumption of pork from controlled housing. Therefore, Trichinella testing of pigs under controlled housing is not adding any value to protect human health. We suggest applying our farm-to-fork QMRA model to further support decision making on the global scale.
[Mh] Termos MeSH primário: Carne Vermelha/parasitologia
Doenças dos Suínos/parasitologia
Trichinella/isolamento & purificação
Triquinelose/parasitologia
Triquinelose/veterinária
[Mh] Termos MeSH secundário: Animais
Animais Selvagens/parasitologia
Culinária
União Europeia
Seres Humanos
Incidência
Carne/parasitologia
Músculos/parasitologia
Polônia
Medição de Risco
Sus scrofa
Suínos
Trichinella/genética
Trichinella/fisiologia
Triquinelose/transmissão
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170917
[Lr] Data última revisão:
170917
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161107
[St] Status:MEDLINE


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[PMID]:27582037
[Au] Autor:Reichard MV; Logan K; Criffield M; Thomas JE; Paritte JM; Messerly DM; Interisano M; Marucci G; Pozio E
[Ad] Endereço:Department of Veterinary Pathobiology,Center for Veterinary Health Sciences,Oklahoma State University,250 McElroy Hall,Stillwater,OK 74078,USA.
[Ti] Título:The occurrence of Trichinella species in the cougar Puma concolor couguar from the state of Colorado and other regions of North and South America.
[So] Source:J Helminthol;91(3):320-325, 2017 May.
[Is] ISSN:1475-2697
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Trichinella species are zoonotic nematodes that infect wild carnivores and omnivores throughout the world. We examined the prevalence and species of Trichinella infections in cougars (Puma concolor couguar) from Colorado, United States. Tongues from cougars were examined by pepsin-HCl artificial digestion to detect Trichinella spp. larvae. The species or genotype of individual worms was identified by multiplex polymerase chain reaction (PCR). Trichinella spp. larvae were detected in 17 of 39 cougars (43.6% (28.7-59.5%)). Five of the cougars (12.8%) were infected with T. murrelli, 3 (7.7%) were infected with T. pseudospiralis, and 1 (2.6%) had Trichinella genotype T6. Trichinella spp. larvae from eight cougars were not identified at the species level, due to degraded DNA. The high prevalence of Trichinella spp. in cougars from Colorado and reports of the parasite in other populations of Puma spp. suggest that this large predator is a key mammalian reservoir.
[Mh] Termos MeSH primário: Puma/parasitologia
Trichinella/isolamento & purificação
Triquinelose/veterinária
[Mh] Termos MeSH secundário: Américas/epidemiologia
Animais
Larva/classificação
Larva/genética
Reação em Cadeia da Polimerase Multiplex
Prevalência
Língua/parasitologia
Trichinella/classificação
Trichinella/genética
Triquinelose/epidemiologia
Triquinelose/parasitologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170407
[Lr] Data última revisão:
170407
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160902
[St] Status:MEDLINE
[do] DOI:10.1017/S0022149X16000262



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