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  1 / 2033 MEDLINE  
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[PMID]:29261659
[Au] Autor:Tahir D; Almeras L; Varloud M; Raoult D; Davoust B; Parola P
[Ad] Endereço:Unité de Recherche en Maladies Infectieuses et Tropicales Emergentes (URMITE), Aix-Marseille Université, UM63, CNRS 7278, IRD 198 (Dakar), Inserm 1095, AP-HM Institut Hospitalo-Universitaire Méditerranée Infection, Marseille, France.
[Ti] Título:Assessment of MALDI-TOF mass spectrometry for filariae detection in Aedes aegypti mosquitoes.
[So] Source:PLoS Negl Trop Dis;11(12):e0006093, 2017 12.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Matrix Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry (MALDI-TOF MS) is an emerging tool for routine identification of bacteria, archaea and fungi. It has also been recently applied as an accurate approach for arthropod identification. Preliminary studies have shown that the MALDI-TOF MS was able to differentiate whether ticks and mosquitoes were infected or not with some bacteria and Plasmodium parasites, respectively. The aim of the present study was to test the efficiency of MALDI-TOF MS tool in distinguishing protein profiles between uninfected mosquitoes from specimens infected by filarioid helminths. Aedes aegypti mosquitoes were engorged on microfilaremic blood infected with Dirofilaria immitis, Brugia malayi or Brugia pahangi. Fifteen days post-infective blood feeding, a total of 534 mosquitoes were killed by freezing. To assess mass spectra (MS) profile changes following filariae infections, one compartment (legs, thorax, head or thorax and head) per mosquito was submitted for MALDI-TOF MS analysis; the remaining body parts were used to establish filariae infectious status by real-time qPCR. A database of reference MS, based on the mass profiles of at least two individual mosquitoes per compartment, was created. Subsequently, the remaining compartment spectra (N = 350) from Ae. aegypti infected or not infected by filariae were blind tested against the spectral database. In total, 37 discriminating peak masses ranging from 2062 to 14869 daltons were identified, of which 17, 11, 12 and 7 peak masses were for legs, thorax, thorax-head and head respectively. Two peak masses (4073 and 8847 Da) were specific to spectra from Ae. aegypti infected with filariae, regardless of nematode species or mosquito compartment. The thorax-head part provided better classification with a specificity of 94.1% and sensitivity of 86.6, 71.4 and 68.7% of D. immitis, B. malayi and B. pahangi respectively. This study presents the potential of MALDI-TOF MS as a reliable tool for differentiating non-infected and filariae-infected Ae. aegypti mosquitoes. Considering that the results might vary in other mosquito species, further studies are needed to consolidate the obtained preliminary results before applying this tool in entomological surveillance as a fast mass screening method of filariosis vectors in endemic areas.
[Mh] Termos MeSH primário: Aedes/parasitologia
Filariose/parasitologia
Filarioidea/isolamento & purificação
Espectrometria de Massas por Ionização e Dessorção a Laser Assistida por Matriz/métodos
[Mh] Termos MeSH secundário: Aedes/metabolismo
Animais
Brugia Malayi/genética
Brugia Malayi/isolamento & purificação
Brugia pahangi/genética
Brugia pahangi/isolamento & purificação
Dirofilaria immitis/genética
Dirofilaria immitis/isolamento & purificação
Feminino
Filarioidea/genética
Proteínas de Insetos/análise
Sensibilidade e Especificidade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Insect Proteins)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171221
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0006093


  2 / 2033 MEDLINE  
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[PMID]:29207343
[Au] Autor:Gucchait A; Joardar N; Parida PK; Roy P; Mukherjee N; Dutta A; Yesuvadian R; SinhaBabu SP; Jana K; Misra AK
[Ad] Endereço:Bose Institute, Division of Molecular Medicine, P-1/12, C.I.T. Scheme VII-M, Kolkata, 700054, India.
[Ti] Título:Development of novel anti-filarial agents using carbamo(dithioperoxo)thioate derivatives.
[So] Source:Eur J Med Chem;143:598-610, 2018 Jan 01.
[Is] ISSN:1768-3254
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:A series of novel carbamo(dithioperoxo)thioate derivatives have been prepared in excellent yield using a significantly fast, one-pot three component reaction and experimented for their potential as anti-filarial agents against model filarial nematode Setaria cervi. Among 23 compounds (4a-w) evaluated for the anti-filarial activities, five compounds (4a, 4b, 4c, 4d and 4h) have shown promising anti-proliferative effects on the juvenile stage microfilariae (mf) as well as in adults in a time and dose dependent manner. Compound 4a was found most active against oocytes, mf and adult nematods as well as non-cytotoxic to the normal cells. It has been established that the anti-filarial activity of the compounds were observed due to the involvement of reactive oxygen species (ROS) and apoptosis. Several biochemical and microscopic experiments have been carried out to establish the fact that both intrinsic and extrinsic pathways of apoptosis contribute to the compound 4a mediated death phenomenon of the filarial nematodes.
[Mh] Termos MeSH primário: Filarioidea/efeitos dos fármacos
Compostos de Sulfidrila/farmacologia
[Mh] Termos MeSH secundário: Animais
Apoptose/efeitos dos fármacos
Relação Dose-Resposta a Droga
Estrutura Molecular
Oócitos/efeitos dos fármacos
Relação Quantitativa Estrutura-Atividade
Espécies Reativas de Oxigênio/metabolismo
Compostos de Sulfidrila/síntese química
Compostos de Sulfidrila/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Reactive Oxygen Species); 0 (Sulfhydryl Compounds)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180110
[Lr] Data última revisão:
180110
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171206
[St] Status:MEDLINE


  3 / 2033 MEDLINE  
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[PMID]:28891597
[Au] Autor:Kanamitie JN; Ahorlu CS; Otchere J; Aboagye-Antwi F; Kwansa-Bentum B; Boakye DA; Biritwum NK; Wilson MD; de Souza DK
[Ad] Endereço:Department of Animal Biology and Conservation Science, University of Ghana, Accra, Ghana.
[Ti] Título:Twelve-month longitudinal parasitological assessment of lymphatic filariasis-positive individuals: impact of a biannual treatment with ivermectin and albendazole.
[So] Source:Trop Med Int Health;22(11):1451-1456, 2017 Nov.
[Is] ISSN:1365-3156
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Mass drug administration (MDA) for the control of lymphatic filariasis (LF), in Ghana, started in the year 2000. While this had great success in many implementation units, there remain areas with persistent transmission, after more than 10 years of treatment. A closer examination of the parasite populations could help understand the reasons for persistent infections and formulate appropriate strategies to control LF in these areas of persistent transmission. MATERIALS AND METHODS: In a longitudinal study, we assessed the prevalence of microfilaraemia (mf) in two communities with 12 years of MDA in Ghana. In baseline surveys 6 months after the National MDA in 2014, 370 consenting individuals were tested for antigenaemia using immunochromatographic test (ICT) cards and had their mf count determined through night blood surveys. 48 ICT positives, of whom, 17 were positive for mf, were treated with 400 µg/kg ivermectin + 400 mg albendazole and subsequently followed for parasitological assessment at 3-month intervals for 1 year. This overlapped with the National MDA in 2015. RESULTS: There was a 68% parasite clearance 3 months after treatment. The pre-treatment mf count differed significantly from the post-treatment mf counts at 3 months (P = 0.0023), 6 months (P = 0.0051), 9 months (P = 0.0113) and 12 months (P = 0.0008). CONCLUSION: In these settings with persistent LF transmission, twice-yearly treatment may help accelerate LF elimination. Further large-scale evaluations are required to ascertain these findings.
[Mh] Termos MeSH primário: Albendazol/uso terapêutico
Filariose Linfática/parasitologia
Filaricidas/uso terapêutico
Filarioidea/crescimento & desenvolvimento
Ivermectina/uso terapêutico
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Albendazol/farmacologia
Animais
Antígenos de Helmintos/sangue
Criança
Filariose Linfática/sangue
Filariose Linfática/epidemiologia
Filariose Linfática/prevenção & controle
Feminino
Filaricidas/farmacologia
Filarioidea/efeitos dos fármacos
Gana/epidemiologia
Programas Governamentais
Seres Humanos
Ivermectina/farmacologia
Estudos Longitudinais
Masculino
Microfilárias/efeitos dos fármacos
Microfilárias/crescimento & desenvolvimento
Meia-Idade
Prevalência
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antigens, Helminth); 0 (Filaricides); 70288-86-7 (Ivermectin); F4216019LN (Albendazole)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171109
[Lr] Data última revisão:
171109
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170912
[St] Status:MEDLINE
[do] DOI:10.1111/tmi.12974


  4 / 2033 MEDLINE  
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[PMID]:28486498
[Au] Autor:Karadjian G; Fercoq F; Pionnier N; Vallarino-Lhermitte N; Lefoulon E; Nieguitsila A; Specht S; Carlin LM; Martin C
[Ad] Endereço:Unité Molécules de Communication et Adaptation des Microorganismes (MCAM, UMR 7245), Sorbonne Universités, Muséum national d'Histoire naturelle, CNRS, Paris, France.
[Ti] Título:Migratory phase of Litomosoides sigmodontis filarial infective larvae is associated with pathology and transient increase of S100A9 expressing neutrophils in the lung.
[So] Source:PLoS Negl Trop Dis;11(5):e0005596, 2017 May.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Filarial infections are tropical diseases caused by nematodes of the Onchocercidae family such as Mansonella perstans. The infective larvae (L3) are transmitted into the skin of vertebrate hosts by blood-feeding vectors. Many filarial species settle in the serous cavities including M. perstans in humans and L. sigmodontis, a well-established model of filariasis in mice. L. sigmodontis L3 migrate to the pleural cavity where they moult into L4 around day 9 and into male and female adult worms around day 30. Little is known of the early phase of the parasite life cycle, after the L3 is inoculated in the dermis by the vector and enters the afferent lymphatic vessels and before the moulting processes in the pleural cavity. Here we reveal a pulmonary phase associated with lung damage characterized by haemorrhages and granulomas suggesting L3 reach the lung via pulmonary capillaries and damage the endothelium and parenchyma by crossing them to enter the pleural cavity. This study also provides evidence for a transient inflammation in the lung characterized by a very early recruitment of neutrophils associated with high expression levels of S100A8 and S100A9 proteins.
[Mh] Termos MeSH primário: Calgranulina B/análise
Filariose/patologia
Filarioidea/crescimento & desenvolvimento
Filarioidea/imunologia
Pulmão/patologia
Neutrófilos/imunologia
[Mh] Termos MeSH secundário: Animais
Modelos Animais de Doenças
Feminino
Filariose/parasitologia
Seres Humanos
Pulmão/parasitologia
Camundongos Endogâmicos BALB C
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Calgranulin B); 0 (S100A9 protein, mouse)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170713
[Lr] Data última revisão:
170713
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170510
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0005596


  5 / 2033 MEDLINE  
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[PMID]:28427478
[Au] Autor:Uni S; Mat Udin AS; Agatsuma T; Saijuntha W; Junker K; Ramli R; Omar H; Lim YA; Sivanandam S; Lefoulon E; Martin C; Belabut DM; Kasim S; Abdullah Halim MR; Zainuri NA; Bhassu S; Fukuda M; Matsubayashi M; Harada M; Low VL; Chen CD; Suganuma N; Hashim R; Takaoka H; Azirun MS
[Ad] Endereço:Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur, 50603, Malaysia. unishigehiko@um.edu.my.
[Ti] Título:Morphological and molecular characteristics of Malayfilaria sofiani Uni, Mat Udin & Takaoka n. g., n. sp. (Nematoda: Filarioidea) from the common treeshrew Tupaia glis Diard & Duvaucel (Mammalia: Scandentia) in Peninsular Malaysia.
[So] Source:Parasit Vectors;10(1):194, 2017 Apr 20.
[Is] ISSN:1756-3305
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The filarial nematodes Wuchereria bancrofti (Cobbold, 1877), Brugia malayi (Brug, 1927) and B. timori Partono, Purnomo, Dennis, Atmosoedjono, Oemijati & Cross, 1977 cause lymphatic diseases in humans in the tropics, while B. pahangi (Buckley & Edeson, 1956) infects carnivores and causes zoonotic diseases in humans in Malaysia. Wuchereria bancrofti, W. kalimantani Palmieri, Pulnomo, Dennis & Marwoto, 1980 and six out of ten Brugia spp. have been described from Australia, Southeast Asia, Sri Lanka and India. However, the origin and evolution of the species in the Wuchereria-Brugia clade remain unclear. While investigating the diversity of filarial parasites in Malaysia, we discovered an undescribed species in the common treeshrew Tupaia glis Diard & Duvaucel (Mammalia: Scandentia). METHODS: We examined 81 common treeshrews from 14 areas in nine states and the Federal Territory of Peninsular Malaysia for filarial parasites. Once any filariae that were found had been isolated, we examined their morphological characteristics and determined the partial sequences of their mitochondrial cytochrome c oxidase subunit 1 (cox1) and 12S rRNA genes. Polymerase chain reaction (PCR) products of the internal transcribed spacer 1 (ITS1) region were then cloned into the pGEM-T vector, and the recombinant plasmids were used as templates for sequencing. RESULTS: Malayfilaria sofiani Uni, Mat Udin & Takaoka, n. g., n. sp. is described based on the morphological characteristics of adults and microfilariae found in common treeshrews from Jeram Pasu, Kelantan, Malaysia. The Kimura 2-parameter distance between the cox1 gene sequences of the new species and W. bancrofti was 11.8%. Based on the three gene sequences, the new species forms a monophyletic clade with W. bancrofti and Brugia spp. The adult parasites were found in tissues surrounding the lymph nodes of the neck of common treeshrews. CONCLUSIONS: The newly described species appears most closely related to Wuchereria spp. and Brugia spp., but differs from these in several morphological characteristics. Molecular analyses based on the cox1 and 12S rRNA genes and the ITS1 region indicated that this species differs from both W. bancrofti and Brugia spp. at the genus level. We thus propose a new genus, Malayfilaria, along with the new species M. sofiani.
[Mh] Termos MeSH primário: Filariose/veterinária
Filarioidea/anatomia & histologia
Filarioidea/genética
Tupaia/parasitologia
[Mh] Termos MeSH secundário: Animais
Brugia/anatomia & histologia
Brugia/genética
DNA Espaçador Ribossômico/genética
Feminino
Filariose/epidemiologia
Filariose/parasitologia
Filarioidea/isolamento & purificação
Malásia
Masculino
Reação em Cadeia da Polimerase
Análise de Sequência de DNA
Wuchereria/anatomia & histologia
Wuchereria/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Ribosomal Spacer)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170918
[Lr] Data última revisão:
170918
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170422
[St] Status:MEDLINE
[do] DOI:10.1186/s13071-017-2105-9


  6 / 2033 MEDLINE  
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[PMID]:28363039
[Au] Autor:Edwards EE; Dangoudoubiyam S; Hoppes SM; Porter BF
[Ti] Título:GRANULOMATOUS FILARIAL ENCEPHALOMYELITIS CAUSED BY CHANDLERELLA QUISCALI IN A NORTHERN CRESTED CARACARA (CARACARA CHERIWAY).
[So] Source:J Zoo Wildl Med;48(1):237-240, 2017 Mar.
[Is] ISSN:1042-7260
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A northern crested caracara (Caracara cheriway) was presented after being found nonambulatory in a field. On physical examination, the bird had severe hind-limb paresis. The bird did not improve after 10 days of hospitalization and was euthanized. Histologic examination of the cerebrum and spinal cord revealed multiple adult filarial nematodes surrounded by granulomatous inflammation with several multinucleated giant cells. These parasites were confirmed to be Chandlerella quiscali with polymerase chain reaction. This is the first report of C. quiscali in a bird of prey.
[Mh] Termos MeSH primário: Doenças das Aves/parasitologia
Helmintíase do Sistema Nervoso Central/veterinária
Encefalomielite/veterinária
Falconiformes
Filariose/veterinária
Filarioidea/isolamento & purificação
[Mh] Termos MeSH secundário: Animais
Helmintíase do Sistema Nervoso Central/parasitologia
Helmintíase do Sistema Nervoso Central/patologia
Filariose/parasitologia
Filarioidea/classificação
Masculino
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170619
[Lr] Data última revisão:
170619
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170401
[St] Status:MEDLINE
[do] DOI:10.1638/2016-0123.1


  7 / 2033 MEDLINE  
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[PMID]:28168837
[Au] Autor:Kwarteng A; Ahuno ST
[Ad] Endereço:Department of Biochemistry and Biotechnology, Kwame Nkrumah University of Science Technology, PMB, Kumasi, Ghana.
[Ti] Título:Immunity in Filarial Infections: Lessons from Animal Models and Human Studies.
[So] Source:Scand J Immunol;85(4):251-257, 2017 Apr.
[Is] ISSN:1365-3083
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Our understanding of immunity to filarial infection is enigmatic and continues to be passionately debated. The mechanisms whereby filarial nematodes are killed in vivo and how these parasites avoid these mechanisms are poorly understood. Although vaccination studies in permissive animals took off seven decades ago, the exact mechanisms driving protective immunity are extensively being investigated. Currently, little is known regarding the collective functions or counter-regulatory mechanisms of the antibody isotypes in filarial infection with respect to protective immunity. Establishing the functional role of antibody isotypes and cytokines in the various infection phenotypes can contribute immensely to current knowledge in filarial immunology. This paper reviews insight into protective immunity in filarial infection with focus on humoral and cellular responses from animal models and human studies.
[Mh] Termos MeSH primário: Anticorpos Anti-Helmínticos/imunologia
Filariose/imunologia
Filarioidea/imunologia
Células Th1/imunologia
Células Th2/imunologia
[Mh] Termos MeSH secundário: Animais
Antígenos de Helmintos/imunologia
Citocinas/imunologia
Modelos Animais de Doenças
Filariose/parasitologia
Seres Humanos
Camundongos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Antibodies, Helminth); 0 (Antigens, Helminth); 0 (Cytokines)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170421
[Lr] Data última revisão:
170421
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170208
[St] Status:MEDLINE
[do] DOI:10.1111/sji.12533


  8 / 2033 MEDLINE  
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[PMID]:27923052
[Au] Autor:Dietze KK; Dittmer U; Koudaimi DK; Schimmer S; Reitz M; Breloer M; Hartmann W
[Ad] Endereço:Institute of Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
[Ti] Título:Filariae-Retrovirus Co-infection in Mice is Associated with Suppressed Virus-Specific IgG Immune Response and Higher Viral Loads.
[So] Source:PLoS Negl Trop Dis;10(12):e0005170, 2016 Dec.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Worldwide more than 2 billion people are infected with helminths, predominantly in developing countries. Co-infections with viruses such as human immunodeficiency virus (HIV) are common due to the geographical overlap of these pathogens. Helminth and viral infections induce antagonistic cytokine responses in their hosts. Helminths shift the immune system to a type 2-dominated immune response, while viral infections skew the cytokine response towards a type 1 immune response. Moreover, chronic helminth infections are often associated with a generalized suppression of the immune system leading to prolonged parasite survival, and also to a reduced defence against unrelated pathogens. To test whether helminths affect the outcome of a viral infection we set up a filarial/retrovirus co-infection model in C57BL/6 mice. Although Friend virus (FV) infection altered the L. sigmodontis-specific immunoglobulin response towards a type I associated IgG2 isotype in co-infected mice, control of L. sigmodontis infection was not affected by a FV-superinfection. However, reciprocal control of FV infection was clearly impaired by concurrent L. sigmodontis infection. Spleen weight as an indicator of pathology and viral loads in spleen, lymph nodes (LN) and bone marrow (BM) were increased in L. sigmodontis/FV-co-infected mice compared to only FV-infected mice. Numbers of FV-specific CD8+ T cells as well as cytokine production by CD4+ and CD8+ cells were alike in co-infected and FV-infected mice. Increased viral loads in co-infected mice were associated with reduced titres of neutralising FV-specific IgG2b and IgG2c antibodies. In summary our findings suggest that helminth infection interfered with the control of retroviral infection by dampening the virus-specific neutralising antibody response.
[Mh] Termos MeSH primário: Anticorpos Antivirais/imunologia
Coinfecção/imunologia
Filariose/imunologia
Vírus da Leucemia Murina de Friend
Imunoglobulina G/sangue
Infecções por Retroviridae/imunologia
Carga Viral
[Mh] Termos MeSH secundário: Animais
Anticorpos Anti-Helmínticos/sangue
Anticorpos Anti-Helmínticos/imunologia
Anticorpos Neutralizantes/imunologia
Anticorpos Antivirais/sangue
Medula Óssea/virologia
Linfócitos T CD8-Positivos/imunologia
Coinfecção/parasitologia
Coinfecção/virologia
Modelos Animais de Doenças
Filariose/parasitologia
Filariose/virologia
Filarioidea/imunologia
Filarioidea/isolamento & purificação
Vírus da Leucemia Murina de Friend/imunologia
Vírus da Leucemia Murina de Friend/isolamento & purificação
Seres Humanos
Imunoglobulina G/imunologia
Camundongos
Camundongos Endogâmicos C57BL
Infecções por Retroviridae/parasitologia
Infecções por Retroviridae/virologia
Baço/imunologia
Baço/patologia
Baço/virologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Helminth); 0 (Antibodies, Neutralizing); 0 (Antibodies, Viral); 0 (Immunoglobulin G)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170628
[Lr] Data última revisão:
170628
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161207
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0005170


  9 / 2033 MEDLINE  
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[PMID]:27716412
[Au] Autor:Kwarteng A; Ahuno ST; Akoto FO
[Ad] Endereço:Kumasi Centre for Collaborative Research in Tropical Medicine (KCCR), PMB, KNUST, Kumasi, Ghana. senkwarteng@yahoo.co.uk.
[Ti] Título:Killing filarial nematode parasites: role of treatment options and host immune response.
[So] Source:Infect Dis Poverty;5(1):86, 2016 Oct 03.
[Is] ISSN:2049-9957
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: There is compelling evidence that not only do anti-filarials significantly reduce larval forms, but that host immune responses also contribute to the clearance of filarial parasites; however, the underlying mechanisms have not been fully elucidated. MAIN TEXT: Filarial infections caused by Wuchereria bancrofti and Brugia species (lymphatic filariasis) and Onchocerca volvulus (onchocerciasis) affect almost 200 million individuals worldwide and pose major public health challenges in endemic regions. Indeed, the collective disability-adjusted life years for both infections is 3.3 million. Infections with these thread-like nematodes are chronic and, although most individuals develop a regulated state, a portion develop severe forms of pathology. Mass drug administration (MDA) programmes on endemic populations focus on reducing prevalence of people with microfilariae, the worm's offspring in the blood, to less than 1 %. Although this has been successful in some areas, studies show that MDA will be required for longer than initially conceived. CONCLUSION: This paper highlights the mode of action of the various antifilarial treatment strategies and role of host immune response.
[Mh] Termos MeSH primário: Filariose/tratamento farmacológico
Filariose/imunologia
Filaricidas/farmacologia
Filarioidea/efeitos dos fármacos
Imunidade Inata
[Mh] Termos MeSH secundário: Animais
Filariose/parasitologia
Seres Humanos
Microfilárias/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Filaricides)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161008
[St] Status:MEDLINE


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[PMID]:27664097
[Au] Autor:Bernard J; Grunenwald C; Stalis IH; Varney M; Zuba J; Gerhold R
[Ad] Endereço:Wildlife Disease Laboratories, San Diego Zoo Institute for Conservation Research, San Diego Zoo Global, San Diego, CA (Bernard, Stalis, Varney)Department of Biomedical and Diagnostic Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, TN (Gerhold, Grunenwald)Department of V
[Ti] Título:Elaeophora in the meninges of a Malayan sambar (Rusa unicolor equina).
[So] Source:J Vet Diagn Invest;28(6):735-738, 2016 Nov.
[Is] ISSN:1943-4936
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:An adult nematode was grossly identified in the meninges of a Malayan sambar (Rusa unicolor equina), with numerous microfilariae associated with encephalitis and vasculitis on histopathology. The nematode was confirmed to be Elaeophora schneideri by sequencing a portion of the 18S rRNA gene. Our report highlights the potential for aberrant migration of E. schneideri in exotic deer species and the use of advanced testing to specifically identify this metazoan parasite, avoiding misidentification of Parelaphostrongylus tenuis.
[Mh] Termos MeSH primário: Cervos
Filariose/veterinária
Filarioidea/isolamento & purificação
Meningite/veterinária
[Mh] Termos MeSH secundário: Animais
Animais Selvagens
Diagnóstico Diferencial
Filariose/diagnóstico
Filarioidea/genética
Masculino
Meningite/diagnóstico
Reação em Cadeia da Polimerase/veterinária
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160925
[St] Status:MEDLINE



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