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[PMID]:28464026
[Au] Autor:Diemert DJ; Freire J; Valente V; Fraga CG; Talles F; Grahek S; Campbell D; Jariwala A; Periago MV; Enk M; Gazzinelli MF; Bottazzi ME; Hamilton R; Brelsford J; Yakovleva A; Li G; Peng J; Correa-Oliveira R; Hotez P; Bethony J
[Ad] Endereço:Department of Microbiology, Immunology and Tropical Medicine, School of Medicine and Health Sciences, The George Washington University, Washington DC, United States of America.
[Ti] Título:Safety and immunogenicity of the Na-GST-1 hookworm vaccine in Brazilian and American adults.
[So] Source:PLoS Negl Trop Dis;11(5):e0005574, 2017 05.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Necator americanus Glutathione-S-Transferase-1 (Na-GST-1) plays a role in the digestion of host hemoglobin by adult N. americanus hookworms. Vaccination of laboratory animals with recombinant Na-GST-1 is associated with significant protection from challenge infection. Recombinant Na-GST-1 was expressed in Pichia pastoris and adsorbed to aluminum hydroxide adjuvant (Alhydrogel) according to current Good Manufacturing Practice. Two Phase 1 trials were conducted in 142 healthy adult volunteers in the United States and Brazil, first in hookworm-naïve individuals and then in residents of a N. americanus endemic area in Brazil. Volunteers received one of three doses of recombinant Na-GST-1 (10, 30, or 100 µg) adjuvanted with Alhydrogel, adjuvanted with Alhydrogel and co-administered with an aqueous formulation of Glucopyranosyl Lipid A (GLA-AF), or the hepatitis B vaccine. Vaccinations were administered via intramuscular injection on days 0, 56, and 112. Na-GST-1/Alhydrogel was well tolerated in both hookworm-naïve and hookworm-exposed adults, with the most common adverse events being mild to moderate injection site pain and tenderness, and mild headache and nausea; no vaccine-related severe or serious adverse events were observed. Antigen-specific IgG antibodies were induced in a dose-dependent fashion, with increasing levels observed after each vaccination in both trials. The addition of GLA-AF to Na-GST-1/Alhydrogel did not result in significant increases in specific IgG responses. In both the US and Brazil studies, the predominant IgG subclass induced against Na-GST-1 was IgG1, with lesser amounts of IgG3. Vaccination of both hookworm-naïve and hookworm-exposed adults with recombinant Na-GST-1 was safe, well tolerated, and resulted in significant antigen-specific IgG responses. Based on these results, this vaccine will be advanced into clinical trials in children and eventual efficacy studies. TRIAL REGISTRATION: ClinicalTrials.gov (NCT01261130 for the Brazil trial and NCT01385189 for the US trial).
[Mh] Termos MeSH primário: Ancylostomatoidea/imunologia
Antígenos de Helmintos/imunologia
Glutationa Transferase/imunologia
Infecções por Uncinaria/prevenção & controle
Vacinas Sintéticas/imunologia
[Mh] Termos MeSH secundário: Adjuvantes Imunológicos/administração & dosagem
Adolescente
Adulto
Hidróxido de Alumínio/administração & dosagem
Animais
Anticorpos Anti-Helmínticos/sangue
Brasil
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos/epidemiologia
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos/patologia
Feminino
Glucosídeos/administração & dosagem
Voluntários Saudáveis
Vacinas contra Hepatite B/administração & dosagem
Infecções por Uncinaria/imunologia
Seres Humanos
Imunoglobulina G/sangue
Injeções Intramusculares
Lipídeo A/administração & dosagem
Masculino
Meia-Idade
Resultado do Tratamento
Estados Unidos
Vacinas Sintéticas/administração & dosagem
Vacinas Sintéticas/efeitos adversos
Adulto Jovem
[Pt] Tipo de publicação:CLINICAL TRIAL, PHASE I; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Adjuvants, Immunologic); 0 (Antibodies, Helminth); 0 (Antigens, Helminth); 0 (Glucosides); 0 (Hepatitis B Vaccines); 0 (Immunoglobulin G); 0 (Lipid A); 0 (Vaccines, Synthetic); 0 (glucopyranosyl lipid-A); 5QB0T2IUN0 (Aluminum Hydroxide); EC 2.5.1.18 (Glutathione Transferase)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:180129
[Lr] Data última revisão:
180129
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[Cl] Clinical Trial:ClinicalTrial
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0005574


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[PMID]:29176840
[Au] Autor:Tran-Thi N; Lowe RJ; Schurer JM; Vu-Van T; MacDonald LE; Pham-Duc P
[Ad] Endereço:Center for Public Health and Ecosystem Research, Hanoi University of Public Health, North Tu Liem, Hanoi, Vietnam.
[Ti] Título:Turning poop into profit: Cost-effectiveness and soil transmitted helminth infection risk associated with human excreta reuse in Vietnam.
[So] Source:PLoS Negl Trop Dis;11(11):e0006088, 2017 Nov.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Human excreta is a low cost source of nutrients vital to plant growth, but also a source of pathogens transmissible to people and animals. We investigated the cost-savings and infection risk of soil transmitted helminths (STHs) in four scenarios where farmers used either inorganic fertilizer or fresh/composted human excreta supplemented by inorganic fertilizer to meet the nutrient requirements of rice paddies in the Red River Delta, Vietnam. Our study included two main components: 1) a risk estimate of STH infection for farmers who handle fresh excreta, determined by systematic review and meta-analysis; and 2) a cost estimate of fertilizing rice paddies, determined by nutrient assessment of excreta, a retailer survey of inorganic fertilizer costs, and a literature review to identify region-specific inputs. Our findings suggest that farmers who reuse fresh excreta are 1.24 (95% CI: 1.13-1.37, p-value<0.001) times more likely to be infected with any STH than those who do not handle excreta or who compost appropriately, and that risk varies by STH type (Ascaris lumbricoides RR = 1.17, 95% CI = 0.87-1.58, p-value = 0.29; Hookworm RR = 1.02, 95% CI = 0.50-2.06, p-value = 0.96; Trichuris trichiura RR = 1.38, 95% CI = 0.79-2.42, p-value = 0.26). Average cost-savings were highest for farmers using fresh excreta (847,000 VND) followed by those who composted for 6 months as recommended by the WHO (312,000 VND) and those who composted for a shorter time (5 months) with lime supplementation (37,000 VND/yr); however, this study did not assess healthcare costs of treating acute or chronic STH infections in the target group. Our study provides evidence that farmers in the Red River Delta are able to use a renewable and locally available resource to their economic advantage, while minimizing the risk of STH infection.
[Mh] Termos MeSH primário: Agricultura/métodos
Ascaríase/transmissão
Fezes/parasitologia
Infecções por Uncinaria/transmissão
Solo/parasitologia
Tricuríase/transmissão
[Mh] Termos MeSH secundário: Ancylostomatoidea/isolamento & purificação
Animais
Ascaríase/parasitologia
Ascaris lumbricoides/isolamento & purificação
Líquidos Corporais/parasitologia
Análise Custo-Benefício
Infecções por Uncinaria/parasitologia
Seres Humanos
Modelos Lineares
Tricuríase/parasitologia
Trichuris/isolamento & purificação
Vietnã
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; REVIEW
[Nm] Nome de substância:
0 (Soil)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171219
[Lr] Data última revisão:
171219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0006088


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[PMID]:28991899
[Au] Autor:Echazú A; Juarez M; Vargas PA; Cajal SP; Cimino RO; Heredia V; Caropresi S; Paredes G; Arias LM; Abril M; Gold S; Lammie P; Krolewiecki AJ
[Ad] Endereço:Instituto de Investigaciones en Enfermedades Tropicales, Universidad Nacional de Salta-Sede Regional Orán, San Ramón de la Nueva Orán, Salta, Argentina.
[Ti] Título:Albendazole and ivermectin for the control of soil-transmitted helminths in an area with high prevalence of Strongyloides stercoralis and hookworm in northwestern Argentina: A community-based pragmatic study.
[So] Source:PLoS Negl Trop Dis;11(10):e0006003, 2017 Oct.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Recommendations for soil-transmitted helminth (STH) control give a key role to deworming of school and pre-school age children with albendazole or mebendazole; which might be insufficient to achieve adequate control, particularly against Strongyloides stercoralis. The impact of preventive chemotherapy (PC) against STH morbidity is still incompletely understood. The aim of this study was to assess the effectiveness of a community-based program with albendazole and ivermectin in a high transmission setting for S. stercoralis and hookworm. METHODOLOGY: Community-based pragmatic trial conducted in Tartagal, Argentina; from 2012 to 2015. Six communities (5070 people) were enrolled for community-based PC with albendazole and ivermectin. Two communities (2721 people) were re-treated for second and third rounds. STH prevalence, anemia and malnutrition were explored through consecutive surveys. Anthropometric assessment of children, stool analysis, complete blood count and NIE-ELISA serology for S. stercoralis were performed. PRINCIPAL FINDINGS: STH infection was associated with anemia and stunting in the baseline survey that included all communities and showed a STH prevalence of 47.6% (almost exclusively hookworm and S. stercoralis). Among communities with multiple interventions, STH prevalence decreased from 62% to 23% (p<0.001) after the first PC; anemia also diminished from 52% to 12% (p<0.001). After two interventions S. stercoralis seroprevalence declined, from 51% to 14% (p<0.001) and stunting prevalence decreased, from 19% to 12% (p = 0.009). CONCLUSIONS: Hookworm' infections are associated with anemia in the general population and nutritional impairment in children. S. stercoralis is also associated with anemia. Community-based deworming with albendazole and ivermectin is effective for the reduction of STH prevalence and morbidity in communities with high prevalence of hookworm and S. stercoralis.
[Mh] Termos MeSH primário: Albendazol/uso terapêutico
Ancylostomatoidea
Infecções por Uncinaria/tratamento farmacológico
Ivermectina/uso terapêutico
Strongyloides stercoralis
Estrongiloidíase/tratamento farmacológico
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Animais
Anti-Helmínticos/uso terapêutico
Argentina/epidemiologia
Criança
Pré-Escolar
Feminino
Seres Humanos
Lactente
Masculino
Meia-Idade
Prevalência
Solo/parasitologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anthelmintics); 0 (Soil); 70288-86-7 (Ivermectin); F4216019LN (Albendazole)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171010
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0006003


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[PMID]:28863133
[Au] Autor:Chadeka EA; Nagi S; Sunahara T; Cheruiyot NB; Bahati F; Ozeki Y; Inoue M; Osada-Oka M; Okabe M; Hirayama Y; Changoma M; Adachi K; Mwende F; Kikuchi M; Nakamura R; Kalenda YDJ; Kaneko S; Hirayama K; Shimada M; Ichinose Y; Njenga SM; Matsumoto S; Hamano S
[Ad] Endereço:Leading Program, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.
[Ti] Título:Spatial distribution and risk factors of Schistosoma haematobium and hookworm infections among schoolchildren in Kwale, Kenya.
[So] Source:PLoS Negl Trop Dis;11(9):e0005872, 2017 Sep.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Large-scale schistosomiasis control programs are implemented in regions with diverse social and economic environments. A key epidemiological feature of schistosomiasis is its small-scale heterogeneity. Locally profiling disease dynamics including risk factors associated with its transmission is essential for designing appropriate control programs. To determine spatial distribution of schistosomiasis and its drivers, we examined schoolchildren in Kwale, Kenya. METHODOLOGY/PRINCIPAL FINDINGS: We conducted a cross-sectional study of 368 schoolchildren from six primary schools. Soil-transmitted helminths and Schistosoma mansoni eggs in stool were evaluated by the Kato-Katz method. We measured the intensity of Schistosoma haematobium infection by urine filtration. The geometrical mean intensity of S. haematobium was 3.1 eggs/10 ml urine (school range, 1.4-9.2). The hookworm geometric mean intensity was 3.2 eggs/g feces (school range, 0-17.4). Heterogeneity in the intensity of S. haematobium and hookworm infections was evident in the study area. To identify factors associated with the intensity of helminth infections, we utilized negative binomial generalized linear mixed models. The intensity of S. haematobium infection was associated with religion and socioeconomic status (SES), while that of hookworm infection was related to SES, sex, distance to river and history of anthelmintic treatment. CONCLUSIONS/SIGNIFICANCE: Both S. haematobium and hookworm infections showed micro-geographical heterogeneities in this Kwale community. To confirm and explain our observation of high S. haematobium risk among Muslims, further extensive investigations are necessary. The observed small scale clustering of the S. haematobium and hookworm infections might imply less uniform strategies even at finer scale for efficient utilization of limited resources.
[Mh] Termos MeSH primário: Ancylostomatoidea/isolamento & purificação
Infecções por Uncinaria/epidemiologia
Schistosoma haematobium/isolamento & purificação
Esquistossomose Urinária/epidemiologia
[Mh] Termos MeSH secundário: Adolescente
Animais
Criança
Estudos Transversais
Demografia
Fezes/parasitologia
Feminino
Seres Humanos
Islamismo
Quênia
Modelos Lineares
Masculino
Contagem de Ovos de Parasitas
Fatores de Risco
Instituições Acadêmicas
Classe Social
Solo/parasitologia
Estudantes/estatística & dados numéricos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Soil)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170902
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0005872


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[PMID]:28483729
[Au] Autor:Karaman Ü; Kolören Z; Seferoglu O; Ayaz E; Demirel E
[Ad] Endereço:Ordu Üniversitesi Tip Fakültesi, Tibbi Parazitoloji Anabilim Dali, Ordu, Türkiye. ulkukaraman44@hotmail.com.
[Ti] Título:Presence of Parasites in Environmental Waters in Samsun and Its Districts.
[So] Source:Turkiye Parazitol Derg;41(1):19-21, 2017 Mar.
[Is] ISSN:2146-3077
[Cp] País de publicação:Turkey
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The aim of this study was to detect the presence of parasites in environmental waters in Samsun and its districts. METHODS: At the center of Samsun, 13 stations were determined. The research was performed between March 2012 and February 2013, and every month, water samples were collected on the dates stated. The samples were stained with Kinyoun acid-fast, modified trichrome, and trichrome dyes after examining with the direct bond. The preparations were evaluated in terms of parasitologic under a light microscope. RESULTS: Totally, 180 of 228 water samples analyzed were from streams; of these, 48 were drinking water samples. The following were found: 142 Giardia spp., 132 Cryptosporidium spp., 56 Cyclospora spp., 38 microsporidia, 47 Blastocystis spp., 38 Entamoeba coli cysts, 18 Dientamoeba, 9 Chilomastix, 9 Strongyloides spp., and 6 hookworms. CONCLUSION: The widespread use of animal husbandry and agriculture in the region and the use of stream surroundings as a grazing area increase the presence of some determined protozoa during a certain period. Parasitological studies in humans and animals in the region should be conducted, and control programs should be applied.
[Mh] Termos MeSH primário: Parasitos/isolamento & purificação
Rios/parasitologia
[Mh] Termos MeSH secundário: Agricultura
Ancylostomatoidea/crescimento & desenvolvimento
Ancylostomatoidea/isolamento & purificação
Animais
Blastocystis/crescimento & desenvolvimento
Blastocystis/isolamento & purificação
Corantes
Cryptosporidium/crescimento & desenvolvimento
Cryptosporidium/isolamento & purificação
Cyclospora/crescimento & desenvolvimento
Cyclospora/isolamento & purificação
Dientamoeba/crescimento & desenvolvimento
Dientamoeba/isolamento & purificação
Entamoeba/crescimento & desenvolvimento
Entamoeba/isolamento & purificação
Giardia/crescimento & desenvolvimento
Giardia/isolamento & purificação
Seres Humanos
Microsporídios/crescimento & desenvolvimento
Microsporídios/isolamento & purificação
Parasitos/classificação
Parasitos/crescimento & desenvolvimento
Retortamonadídeos/crescimento & desenvolvimento
Retortamonadídeos/isolamento & purificação
Coloração e Rotulagem
Strongyloides/crescimento & desenvolvimento
Strongyloides/isolamento & purificação
Turquia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Coloring Agents)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171108
[Lr] Data última revisão:
171108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170510
[St] Status:MEDLINE
[do] DOI:10.5152/tpd.2017.3574


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[PMID]:28379956
[Au] Autor:Steinbaum L; Kwong LH; Ercumen A; Negash MS; Lovely AJ; Njenga SM; Boehm AB; Pickering AJ; Nelson KL
[Ad] Endereço:Civil and Environmental Engineering, Stanford University, Stanford, California, United States of America.
[Ti] Título:Detecting and enumerating soil-transmitted helminth eggs in soil: New method development and results from field testing in Kenya and Bangladesh.
[So] Source:PLoS Negl Trop Dis;11(4):e0005522, 2017 Apr.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Globally, about 1.5 billion people are infected with at least one species of soil-transmitted helminth (STH). Soil is a critical environmental reservoir of STH, yet there is no standard method for detecting STH eggs in soil. We developed a field method for enumerating STH eggs in soil and tested the method in Bangladesh and Kenya. The US Environmental Protection Agency (EPA) method for enumerating Ascaris eggs in biosolids was modified through a series of recovery efficiency experiments; we seeded soil samples with a known number of Ascaris suum eggs and assessed the effect of protocol modifications on egg recovery. We found the use of 1% 7X as a surfactant compared to 0.1% Tween 80 significantly improved recovery efficiency (two-sided t-test, t = 5.03, p = 0.007) while other protocol modifications-including different agitation and flotation methods-did not have a significant impact. Soil texture affected the egg recovery efficiency; sandy samples resulted in higher recovery compared to loamy samples processed using the same method (two-sided t-test, t = 2.56, p = 0.083). We documented a recovery efficiency of 73% for the final improved method using loamy soil in the lab. To field test the improved method, we processed soil samples from 100 households in Bangladesh and 100 households in Kenya from June to November 2015. The prevalence of any STH (Ascaris, Trichuris or hookworm) egg in soil was 78% in Bangladesh and 37% in Kenya. The median concentration of STH eggs in soil in positive samples was 0.59 eggs/g dry soil in Bangladesh and 0.15 eggs/g dry soil in Kenya. The prevalence of STH eggs in soil was significantly higher in Bangladesh than Kenya (chi-square, χ2 = 34.39, p < 0.001) as was the concentration (Mann-Whitney, z = 7.10, p < 0.001). This new method allows for detecting STH eggs in soil in low-resource settings and could be used for standardizing soil STH detection globally.
[Mh] Termos MeSH primário: Ancylostomatoidea/isolamento & purificação
Ascaris/isolamento & purificação
Solo/parasitologia
Trichuris/isolamento & purificação
[Mh] Termos MeSH secundário: Animais
Ascaríase/epidemiologia
Ascaríase/parasitologia
Bangladesh/epidemiologia
Infecções por Uncinaria/epidemiologia
Infecções por Uncinaria/parasitologia
Seres Humanos
Quênia/epidemiologia
Microscopia
Contagem de Ovos de Parasitas
Prevalência
Tricuríase/epidemiologia
Tricuríase/parasitologia
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Soil)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170406
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0005522


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[PMID]:28212668
[Au] Autor:Oswald WE; Stewart AE; Kramer MR; Endeshaw T; Zerihun M; Melak B; Sata E; Gessese D; Teferi T; Tadesse Z; Guadie B; King JD; Emerson PM; Callahan EK; Freeman MC; Flanders WD; Clasen TF; Moe CL
[Ad] Endereço:Department of Disease Control, London School of Hygiene and Tropical Medicine, London, UK. william.oswald@lshtm.ac.uk.
[Ti] Título:Association of community sanitation usage with soil-transmitted helminth infections among school-aged children in Amhara Region, Ethiopia.
[So] Source:Parasit Vectors;10(1):91, 2017 Feb 17.
[Is] ISSN:1756-3305
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Globally, in 2010, approximately 1.5 billion people were infected with at least one species of soil-transmitted helminth (STH), Ascaris lumbricoides, Trichuris trichiura, hookworm (Ancylostoma duodenale and Necator americanus). Infection occurs through ingestion or contact (hookworm) with eggs or larvae in the environment from fecal contamination. To control these infections, the World Health Organization recommends periodic mass treatment of at-risk populations with deworming drugs. Prevention of these infections typically relies on improved excreta containment and disposal. Most evidence of the relationship between sanitation and STH has focused on household-level access or usage, rather than community-level sanitation usage. We examined the association between the proportion of households in a community with latrines in use and prevalence of STH infections among school-aged children. METHODS: Data on STH prevalence and household latrine usage were obtained during four population-based, cross-sectional surveys conducted between 2011 and 2014 in Amhara, Ethiopia. Multilevel regression was used to estimate the association between the proportion of households in the community with latrines in use and presence of STH infection, indicated by > 0 eggs in stool samples from children 6-15 years old. RESULTS: Prevalence of STH infection was estimated as 22% (95% CI: 20-24%), 14% (95% CI: 13-16%), and 4% (95% CI: 4-5%) for hookworm, A. lumbricoides, and T. trichiura, respectively. Adjusting for individual, household, and community characteristics, hookworm prevalence was not associated with community sanitation usage. Trichuris trichuria prevalence was higher in communities with sanitation usage ≥ 60% versus sanitation usage < 20%. Association of community sanitation usage with A. lumbricoides prevalence depended on household sanitation. Community sanitation usage was not associated with A. lumbricoides prevalence among households with latrines in use. Among households without latrines in use, A. lumbricoides prevalence was higher comparing communities with sanitation usage ≥ 60% versus < 20%. Households with a latrine in use had lower prevalence of A. lumbricoides compared to households without latrines in use only in communities where sanitation usage was ≥ 80%. CONCLUSIONS: We found no evidence of a protective association between community sanitation usage and STH infection. The relationship between STH infection and community sanitation usage may be complex and requires further study.
[Mh] Termos MeSH primário: Ascaríase/epidemiologia
Infecções por Uncinaria/epidemiologia
Saneamento
Solo/parasitologia
Sanitários Públicos
Tricuríase/epidemiologia
Tricuríase/transmissão
[Mh] Termos MeSH secundário: Adolescente
Ancylostomatoidea/isolamento & purificação
Animais
Ascaríase/parasitologia
Ascaríase/transmissão
Ascaris lumbricoides/isolamento & purificação
Criança
Estudos Transversais
Etiópia/epidemiologia
Características da Família
Fezes/parasitologia
Feminino
Helmintos/isolamento & purificação
Infecções por Uncinaria/parasitologia
Infecções por Uncinaria/transmissão
Seres Humanos
Masculino
Prevalência
Inquéritos e Questionários
Tricuríase/parasitologia
Trichuris/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Soil)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170219
[St] Status:MEDLINE
[do] DOI:10.1186/s13071-017-2020-0


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[PMID]:28179024
[Au] Autor:Kepha S; Mwandawiro CS; Anderson RM; Pullan RL; Nuwaha F; Cano J; Njenga SM; Odiere MR; Allen E; Brooker SJ; Nikolay B
[Ad] Endereço:School of Public Health, Makerere University College of Health Sciences, Kampala, Uganda. stellakepha2005@yahoo.com.
[Ti] Título:Impact of single annual treatment and four-monthly treatment for hookworm and Ascaris lumbricoides, and factors associated with residual infection among Kenyan school children.
[So] Source:Infect Dis Poverty;6(1):30, 2017 Feb 09.
[Is] ISSN:2049-9957
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: School-based deworming is widely implemented in various countries to reduce the burden of soil-transmitted helminths (STHs), however, the frequency of drug administration varies in different settings. In this study, we compared the impact of a single annual treatment and 4-monthly treatment over a follow-up among Kenyan school children, and investigated the factors associated with residual infection. METHODS: We performed a secondary analysis of data from a randomized trial investigating whether deworming for STHs alters risk of acquiring malaria. Children received either a single treatment or 4-monthly albendazole treatments were followed longitudinally from February 2014 to October 2014. The relative impact of treatment and factors associated with residual infections were investigated using mixed-effects regression models. Predisposition to infection was assessed based on Spearman's rank and Kendall's Tau correlation coefficients. RESULTS: In the 4-monthly treatment group, the proportion of children infected with hookworm decreased from 59.9 to 5.7%, while Ascaris lumbricoides infections dropped from 55.7 to 6.2%. In the single treatment group, hookworm infections decreased over the same time period from 58.7 to 18.3% (12.6% absolute difference in reduction, 95% CI: 8.9-16.3%), and A. lumbricoides from 56.7 to 23.3% (17.1% absolute difference in reduction, 95% CI: 13.1-21.1%). There was strong evidence for predisposition to both STH types. Residual hookworm infection among children on 4-monthly treatment were associated with male sex and baseline nutritional status, whereas A. lumbricoides infection was associated with individual and school-level infection at baseline, latrine cleanliness at schools. CONCLUSIONS: This study found that 4-monthly treatment w more effective than single annual treatment. Repeated treatments led to dramatic reductions in the intensities of STHs, but did not completely clear infections among school children in Kenya, a presumed reflection of reinfection in a setting where there is ongoing transmission.
[Mh] Termos MeSH primário: Anti-Helmínticos/administração & dosagem
Ascaríase/tratamento farmacológico
Ascaríase/epidemiologia
Infecções por Uncinaria/tratamento farmacológico
Infecções por Uncinaria/epidemiologia
Estudantes
[Mh] Termos MeSH secundário: Adolescente
Albendazol/administração & dosagem
Ancylostomatoidea/efeitos dos fármacos
Animais
Ascaris lumbricoides/isolamento & purificação
Criança
Pré-Escolar
Feminino
Seres Humanos
Quênia/epidemiologia
Estudos Longitudinais
Masculino
Instituições Acadêmicas
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Anthelmintics); F4216019LN (Albendazole)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170221
[Lr] Data última revisão:
170221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170210
[St] Status:MEDLINE
[do] DOI:10.1186/s40249-017-0244-z


  9 / 691 MEDLINE  
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[PMID]:28114401
[Au] Autor:Diemert DJ; Lobato L; Styczynski A; Zumer M; Soares A; Gazzinelli MF
[Ad] Endereço:Department of Microbiology, Immunology and Tropical Medicine, The George Washington University School of Medicine and Health Sciences Washington, DC, United States of America.
[Ti] Título:A Comparison of the Quality of Informed Consent for Clinical Trials of an Experimental Hookworm Vaccine Conducted in Developed and Developing Countries.
[So] Source:PLoS Negl Trop Dis;11(1):e0005327, 2017 Jan.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Informed consent is one of the principal ethical requirements of conducting clinical research, regardless of the study setting. Breaches in the quality of the informed consent process are frequently described in reference to clinical trials conducted in developing countries, due to low levels of formal education, a lack of familiarity with biomedical research, and limited access to health services in these countries. However, few studies have directly compared the quality of the informed consent process in developed and developing countries using the same tool and in similar clinical trials. This study was conducted to compare the quality of the informed consent process of a series of clinical trials of an investigational hookworm vaccine that were performed in Brazil and the United States. A standardized questionnaire was used to assess the ethical quality of the informed consent process in a series of Phase 1 clinical trials of the Na-GST-1/Alhydrogel hookworm vaccine that were conducted in healthy adults in Brazil and the United States. In Brazil, the trial was conducted at two sites, one in the hookworm non-endemic urban area of Belo Horizonte, Minas, and one in the rural, resource-limited town of Americaninhas, both in the state of Minas Gerais; the American trial was conducted in Washington, DC. A 32-question survey was administered after the informed consent document was signed at each of the three trial sites; it assessed participants' understanding of information about the study presented in the document as well as the voluntariness of their decision to participate. 105 participants completed the questionnaire: 63 in Americaninhas, 18 in Belo Horizonte, and 24 in Washington, DC. Overall knowledge about the trial was suboptimal: the mean number of correct answers to questions about study objectives, methods, duration, rights, and potential risks and benefits, was 45.6% in Americaninhas, 65.2% in Belo Horizonte, and 59.1% in Washington, DC. Although there was no difference in the rate of correct answers between participants in Belo Horizonte and Washington, DC, there was a significant gap between participants at these two locations compared to Americaninhas (p = 0.0002 and p = 0.0001, respectively), which had a lower percentage of correct answers. Attitudes towards participating in the clinical trial also differed by site: while approximately 40% had doubts about participating in Washington, DC and Belo Horizonte, only 1.5% had concerns in Americaninhas. Finally, in Belo Horizonte and Washington, high percentages cited a desire to help others as motivation for participating, whereas in Americaninhas, the most common reason for participating was personal interest (p = 0.001). Understanding of information about a Phase 1 clinical trial of an experimental hookworm vaccine following informed consent was suboptimal, regardless of study site. Although overall there were no differences in knowledge between Brazil and the US, a lower level of understanding about the trial was seen in participants at the rural, resource-limited Brazilian site. These findings demonstrate the need for educational interventions directed at potential clinical trial participants, both in developing and developed countries, in order to improve understanding of the informed consent document.
[Mh] Termos MeSH primário: Ancylostomatoidea/imunologia
Infecções por Uncinaria/prevenção & controle
Consentimento Livre e Esclarecido/normas
[Mh] Termos MeSH secundário: Adolescente
Adulto
Ancylostomatoidea/fisiologia
Animais
Brasil
Estudos Transversais
Países em Desenvolvimento/estatística & dados numéricos
Estudos de Avaliação como Assunto
Feminino
Infecções por Uncinaria/parasitologia
Infecções por Uncinaria/psicologia
Seres Humanos
Masculino
Meia-Idade
Inquéritos e Questionários
Estados Unidos
Vacinas/administração & dosagem
Vacinas/imunologia
Adulto Jovem
[Pt] Tipo de publicação:CLINICAL TRIAL, PHASE I; COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Vaccines)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170620
[Lr] Data última revisão:
170620
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170124
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0005327


  10 / 691 MEDLINE  
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[PMID]:27075012
[Au] Autor:Sharma V; Gunjan D; Chhabra P; Sharma R; Rana SS; Bhasin DK
[Ad] Endereço:Assistant Professor, Postgraduate Institute of Medical Education and Research, Chandigarh docvishalsharma@gmail.com.
[Ti] Título:Gastrointestinal bleeding in the tropics: Look for the hookworm.
[So] Source:Trop Doct;47(1):48-51, 2017 Jan.
[Is] ISSN:1758-1133
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Hookworms are recognised as a cause of iron-deficiency anaemia in endemic areas. They are, however, often not considered in the differential diagnosis of overt gastrointestinal bleeding. We report the endoscopic diagnosis of hookworms as the cause of gastrointestinal bleeding in three patients, two of whom had frank haemorrhage with one presenting in hypovolemic shock. Hookworm infestation is an important treatable cause of gastrointestinal bleeding in tropical countries.
[Mh] Termos MeSH primário: Ancylostomatoidea/isolamento & purificação
Hemorragia Gastrointestinal/etiologia
Infecções por Uncinaria/diagnóstico
[Mh] Termos MeSH secundário: Adulto
Animais
Diagnóstico Diferencial
Duodeno/parasitologia
Endoscopia Gastrointestinal
Feminino
Infecções por Uncinaria/complicações
Seres Humanos
Masculino
Meia-Idade
Adulto Jovem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160415
[St] Status:MEDLINE



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