Base de dados : MEDLINE
Pesquisa : B01.050.500.500.294.400.968.400.550 [Categoria DeCS]
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  1 / 9 MEDLINE  
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[PMID]:25855350
[Au] Autor:Luoga W; Mansur F; Lowe A; Duce IR; Buttle DJ; Behnke JM
[Ad] Endereço:School of Life Sciences, University of Nottingham, University Park, Nottingham, NG7 2RD, UK.
[Ti] Título:Factors affecting the anthelmintic efficacy of papaya latex in vivo: host sex and intensity of infection.
[So] Source:Parasitol Res;114(7):2535-41, 2015 Jul.
[Is] ISSN:1432-1955
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The development of plant-derived cysteine proteinases, such as those in papaya latex, as novel anthelmintics requires that the variables affecting efficacy be fully evaluated. Here, we conducted two experiments, the first to test for any effect of host sex and the second to determine whether the intensity of the worm burden carried by mice would influence efficacy. In both experiments, we used the standard C3H mouse reference strain in which papaya latex supernatant (PLS) consistently shows >80 % reduction in Heligmosomoides bakeri worm burdens, but to broaden the perspective, we also included for comparison mice of other strains that are known to respond more poorly to treatment with papaya latex. Our results confirmed that there is a strong genetic influence affecting efficacy of PLS in removing adult worm burdens. However, there was no effect of host sex on efficacy (C3H and NIH) and no effect of infection intensity (C3H and BALB/c). These results offer optimism that plant-derived cysteine proteinases (CPs), such as these from papaya latex, can function as effective anthelmintics, with neither host sex nor infection intensity presenting further hurdles to impede their development for future medicinal and veterinary usage.
[Mh] Termos MeSH primário: Anti-Helmínticos/administração & dosagem
Carica/química
Cisteína Proteases/administração & dosagem
Látex/administração & dosagem
Nematospiroides/efeitos dos fármacos
Extratos Vegetais/administração & dosagem
Proteínas de Plantas/administração & dosagem
Infecções por Strongylida/tratamento farmacológico
[Mh] Termos MeSH secundário: Animais
Anti-Helmínticos/química
Cisteína Proteases/química
Feminino
Látex/química
Masculino
Camundongos
Camundongos Endogâmicos BALB C
Camundongos Endogâmicos C3H
Nematospiroides/fisiologia
Extratos Vegetais/química
Proteínas de Plantas/química
Infecções por Strongylida/parasitologia
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anthelmintics); 0 (Latex); 0 (Plant Extracts); 0 (Plant Proteins); EC 3.4.- (Cysteine Proteases)
[Em] Mês de entrada:1602
[Cu] Atualização por classe:171007
[Lr] Data última revisão:
171007
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150410
[St] Status:MEDLINE
[do] DOI:10.1007/s00436-015-4456-5


  2 / 9 MEDLINE  
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[PMID]:25736575
[Au] Autor:Luoga W; Mansur F; Stepek G; Lowe A; Duce IR; Buttle DJ; Behnke JM
[Ad] Endereço:School of Life Sciences,University of Nottingham,University Park,Nottingham,NG7 2RD,UK.
[Ti] Título:Host genetic influences on the anthelmintic efficacy of papaya-derived cysteine proteinases in mice.
[So] Source:Parasitology;142(7):989-98, 2015 Jun.
[Is] ISSN:1469-8161
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Eight strains of mice, of contrasting genotypes, infected with Heligmosomoides bakeri were studied to determine whether the anthelmintic efficacy of papaya latex varied between inbred mouse strains and therefore whether there is an underlying genetic influence on the effectiveness of removing the intestinal nematode. Infected mice were treated with 330 nmol of crude papaya latex or with 240 nmol of papaya latex supernatant (PLS). Wide variation of response between different mouse strains was detected. Treatment was most effective in C3H (90·5-99·3% reduction in worm counts) and least effective in CD1 and BALB/c strains (36·0 and 40·5%, respectively). Cimetidine treatment did not improve anthelmintic efficacy of PLS in a poor drug responder mouse strain. Trypsin activity, pH and PLS activity did not differ significantly along the length of the gastro-intestinal (GI) tract between poor (BALB/c) and high (C3H) drug responder mouse strains. Our data indicate that there is a genetic component explaining between-mouse variation in the efficacy of a standard dose of PLS in removing worms, and therefore warrant some caution in developing this therapy for wider scale use in the livestock industry, and even in human medicine.
[Mh] Termos MeSH primário: Anti-Helmínticos/farmacologia
Carica/química
Cisteína Proteases/farmacologia
Látex/farmacologia
Proteínas de Plantas/farmacologia
Doenças dos Roedores/genética
Infecções por Strongylida/genética
[Mh] Termos MeSH secundário: Animais
Anti-Helmínticos/metabolismo
Carica/enzimologia
Cimetidina/farmacologia
Cisteína Proteases/metabolismo
Feminino
Trato Gastrointestinal/efeitos dos fármacos
Trato Gastrointestinal/parasitologia
Genótipo
Especificidade de Hospedeiro
Concentração de Íons de Hidrogênio
Látex/metabolismo
Masculino
Camundongos
Camundongos Endogâmicos
Nematospiroides/efeitos dos fármacos
Nematospiroides/fisiologia
Proteínas de Plantas/metabolismo
Doenças dos Roedores/tratamento farmacológico
Doenças dos Roedores/parasitologia
Especificidade da Espécie
Infecções por Strongylida/tratamento farmacológico
Infecções por Strongylida/parasitologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anthelmintics); 0 (Latex); 0 (Plant Proteins); 80061L1WGD (Cimetidine); EC 3.4.- (Cysteine Proteases)
[Em] Mês de entrada:1602
[Cu] Atualização por classe:150508
[Lr] Data última revisão:
150508
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150305
[St] Status:MEDLINE
[do] DOI:10.1017/S003118201500013X


  3 / 9 MEDLINE  
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[PMID]:25303901
[Au] Autor:Zalesny G; Hildebrand J; Paziewska-Harris A; Behnke JM; Harris PD
[Ad] Endereço:Department of Invertebrate Systematics and Ecology, Institute of Biology, Wroclaw University of Environmental and Life Sciences, ul. Kozuchowska 5b, 51-631, Wroclaw, Poland. grzegorz.zalesny@up.wroc.pl.
[Ti] Título:Heligmosomoides neopolygyrus Asakawa & Ohbayashi, 1986, a cryptic Asian nematode infecting the striped field mouse Apodemus agrarius in Central Europe.
[So] Source:Parasit Vectors;7:457, 2014 Oct 11.
[Is] ISSN:1756-3305
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Heligmosomoides polygyrus is a widespread gastro-intestinal nematode infecting wild Apodemus (wood mice) throughout Europe. Using molecular and morphological evidence, we review the status of Heligmosomoides from Apodemus agrarius in Poland previously considered to be an outlying clade of H. polygyrus, to further resolve the status of the laboratory model species, H. bakeri. METHODS: Morphological analysis of the male bursa and the synlophe, and molecular analyses of concatenated nuclear (28S rDNA, ITS1 and ITS2) and mitochondrial (CO1 and cytb) genes, of Heligmosomoides collected from Apodemus agrarius from two sites in Poland and comparison with related heligmosomids from voles and mice in Eurasia. RESULTS: Heligmosomoides neopolygyrus, a heligmosomid nematode from Apodemus species from China and Japan, is recognised for the first time in western Europe infecting Apodemus agrarius in Poland. It can be distinguished from H. polygyrus by the filiform externo-dorsal rays of the male copulatory bursa and the small, equally distributed longitudinal crêtes on the body. Specimens from A. agrarius are 20% different at ribosomal (ITS1 and ITS2) nuclear loci, and 10% different at the mitochondrial cytb locus from H. polygyrus, and in phylogenetic analyses group with the vole-infecting genus Heligmosomum. CONCLUSIONS: Despite morphological similarity, H. neopolygyrus is only distantly related to H. polygyrus from western European Apodemus, and may be more closely related to vole-infecting taxa. It was brought into Europe by the recent rapid migration of the host mice. Inclusion of H. neopolygyrus in phylogenies makes it clear that Heligmosomoides is paraphyletic, with the pika-infecting Ohbayashinema and the vole-infecting Heligmosomum nesting within it. Clarification of the European status of H. neopolygyrus also allows H. bakeri, the laboratory model species, to be seen as a terminal sister clade to H. polygyrus, rather than as an internal clade of the latter taxon.
[Mh] Termos MeSH primário: Murinae
Infecções por Nematoides/veterinária
Nematospiroides/isolamento & purificação
Doenças dos Roedores/parasitologia
[Mh] Termos MeSH secundário: Animais
Masculino
Infecções por Nematoides/epidemiologia
Polônia/epidemiologia
Doenças dos Roedores/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1511
[Cu] Atualização por classe:150430
[Lr] Data última revisão:
150430
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141012
[St] Status:MEDLINE
[do] DOI:10.1186/s13071-014-0457-y


  4 / 9 MEDLINE  
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[PMID]:24960299
[Au] Autor:Tritten L; Keiser J; Karwa T; Utzinger J; Holmes E; Saric J
[Ad] Endereço:Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland.
[Ti] Título:Comparing systemic metabolic responses in mice to single or dual infection with Plasmodium berghei and Heligmosomoides bakeri.
[So] Source:Mol Biosyst;10(9):2358-67, 2014 Jul 29.
[Is] ISSN:1742-2051
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Concomitant infections with Plasmodium and gastrointestinal nematodes are frequently observed in humans. At the metabolic level, the cross-talk between the host and multiple coexisting pathogens is poorly characterized. The purpose of this study was to give a comprehensive insight into the systemic metabolic phenotype of mice with a single or dual infection with Plasmodium berghei and Heligmosomoides bakeri. Four groups of eight NMRI female mice were infected with P. berghei or H. bakeri, or with both species concurrently. An additional group remained uninfected, and served as control. Mice were sacrificed at day 19 of the experiment. We collected samples from the liver, spleen, kidney, three intestinal regions, and four brain regions. All biological samples were subjected to (1)H nuclear magnetic resonance spectroscopy, combined with multivariate data analysis, to establish metabolic fingerprints of each tissue from the various infection groups. Compared to uninfected mice, single and dual species infection models showed unique metabolic profiles. P. berghei exerted major effects on glycolysis, tricarboxylic acid cycle, and nucleotide and amino acid metabolism in all studied tissues with the exception of the gut. H. bakeri was characterized by a dysregulation of choline and lipid metabolism in most tissues examined with a particularly strong imprint in the jejunum. Simultaneous co-infection with P. berghei and H. bakeri induced the strongest and most diverse effects in the liver and spleen but led to only minor changes in the intestinal and cerebral parts assessed. Infection with P. berghei showed more pronounced and systemic alterations in the mice metabolic profile than H. bakeri infection. The metabolic fingerprints in the co-infection models were driven by P. berghei infection, whilst the presence of H. bakeri in co-infections had little effect. However, simultaneous co-infection showed indeed the least metabolic disruptions in the peripheral tissues, namely the gut and brain.
[Mh] Termos MeSH primário: Coinfecção/metabolismo
Coinfecção/parasitologia
Malária/metabolismo
Malária/parasitologia
Infecções por Strongylida/metabolismo
Infecções por Strongylida/parasitologia
[Mh] Termos MeSH secundário: Aminoácidos/metabolismo
Animais
Encéfalo/metabolismo
Encéfalo/parasitologia
Colina/metabolismo
Ciclo do Ácido Cítrico/fisiologia
Feminino
Glicólise/fisiologia
Intestinos/metabolismo
Intestinos/parasitologia
Rim/metabolismo
Rim/parasitologia
Metabolismo dos Lipídeos/fisiologia
Fígado/metabolismo
Fígado/parasitologia
Espectroscopia de Ressonância Magnética/métodos
Metabolômica/métodos
Camundongos
Nematospiroides
Nucleotídeos/metabolismo
Plasmodium berghei
Baço/metabolismo
Baço/parasitologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Amino Acids); 0 (Nucleotides); N91BDP6H0X (Choline)
[Em] Mês de entrada:1510
[Cu] Atualização por classe:140730
[Lr] Data última revisão:
140730
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140625
[St] Status:MEDLINE
[do] DOI:10.1039/c4mb00097h


  5 / 9 MEDLINE  
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[PMID]:21767435
[Au] Autor:Coltherd JC; Babayan SA; Bünger L; Kyriazakis I; Allen JE; Houdijk JG
[Ad] Endereço:Animal Health, SAC, West Mains Road, Edinburgh EH9 3JG, UK. jcoltherd@hotmail.com
[Ti] Título:Interactive effects of protein nutrition, genetic growth potential and Heligmosomoides bakeri infection pressure on resilience and resistance in mice.
[So] Source:Parasitology;138(10):1305-15, 2011 Sep.
[Is] ISSN:1469-8161
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The ability of animals to cope with an increasing parasite load, in terms of resilience and resistance, may be affected by both nutrient supply and demand. Here, we hypothesized that host nutrition and growth potential interact and influence the ability of mice to cope with different parasite doses. Mice selected for high (ROH) or low (ROL) body weight were fed a low (40 g/kg; LP) or high (230 g/kg; HP) protein diet and infected with 0, 50, 100, 150, 200 or 250 L3 infective Heligmosomoides bakeri larvae. ROH-LP mice grew less at doses of 150 L3 and above, whilst growth of ROH-HP and of ROL mice was not affected by infection pressure. Total worm burdens reached a plateau at doses of 150L3, whilst ROH mice excreted fewer worm eggs than ROL mice. Serum antibodies increased with infection dose and ROH mice were found to have higher parasite-specific IgG1 titres than ROL mice. In contrast, ROL had higher total IgE titres than ROH mice, only on HP diets. The interaction between host nutrition and growth potential appears to differentially affect resilience and resistance in mice. However, the results support the view that parasitism penalises performance in animals selected for higher growth.
[Mh] Termos MeSH primário: Anticorpos Anti-Helmínticos/sangue
Estado Nutricional/imunologia
Doenças dos Roedores/imunologia
Infecções por Strongylida/imunologia
[Mh] Termos MeSH secundário: Animais
Peso Corporal
Cruzamentos Genéticos
Dieta
Proteínas na Dieta/metabolismo
Ensaio de Imunoadsorção Enzimática
Fezes/parasitologia
Imunoglobulina E/sangue
Imunoglobulina G/sangue
Larva/patogenicidade
Larva/fisiologia
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Camundongos Endogâmicos DBA
Nematospiroides/patogenicidade
Nematospiroides/fisiologia
Contagem de Ovos de Parasitas
Carga Parasitária
Doenças dos Roedores/sangue
Doenças dos Roedores/parasitologia
Infecções por Strongylida/sangue
Infecções por Strongylida/parasitologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antibodies, Helminth); 0 (Dietary Proteins); 0 (Immunoglobulin G); 37341-29-0 (Immunoglobulin E)
[Em] Mês de entrada:1112
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:110720
[St] Status:MEDLINE
[do] DOI:10.1017/S0031182011000990


  6 / 9 MEDLINE  
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[PMID]:19523257
[Au] Autor:Coltherd JC; Bünger L; Kyriazakis I; Houdijk JG
[Ad] Endereço:Animal Health, SAC, Edinburgh EH9 3JG, UK. Jennifer.Coltherd@sac.ac.uk
[Ti] Título:Genetic growth potential interacts with nutrition on the ability of mice to cope with Heligmosomoides bakeri infection.
[So] Source:Parasitology;136(9):1043-55, 2009 Aug.
[Is] ISSN:1469-8161
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Artificial selection for improved productivity may reduce an animal's ability to cope with pathogens. Here, we used Roslin mice, uniquely divergently selected for high (ROH) and low (ROL) body weight, to assess interactive effects of differing growth potential and protein nutrition on host resilience and resistance. In a 2 x 2 x 6 factorial design, ROH and ROL mice were either sham-infected or infected with 250 L(3)Heligmosomoides bakeri and fed diets with 30, 80, 130, 180, 230 and 280 g crude protein per kg. The infected ROL-30 treatment resulted in clinical disease and was discontinued. In the remaining ROL mice, infection and feeding treatments did not affect growth but infection reduced weight gain in ROH-30, ROH-80 and ROH-130 mice. Although infection resulted in temporarily reduced food intake (anorexia) in both mouse lines, mean food intake over the whole experiment was reduced in ROH mice only. ROH mice excreted more worm eggs and had higher worm burdens, with relatively fewer female worms, than ROL mice. However, these resistance traits were not sensitive to dietary protein. These results support the view that selection for high growth may reduce the ability to cope with pathogens, and that improved protein nutrition may to some extent ameliorate this penalty.
[Mh] Termos MeSH primário: Peso Corporal/genética
Predisposição Genética para Doença
Camundongos Endogâmicos/genética
Nematospiroides
Infecções por Strongylida/veterinária
[Mh] Termos MeSH secundário: Tecido Adiposo
Ração Animal/análise
Fenômenos Fisiológicos da Nutrição Animal
Animais
Proteínas na Dieta
Ingestão de Alimentos
Feminino
Camundongos
Contagem de Ovos de Parasitas
Infecções por Strongylida/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Dietary Proteins)
[Em] Mês de entrada:0909
[Cu] Atualização por classe:090714
[Lr] Data última revisão:
090714
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:090616
[St] Status:MEDLINE
[do] DOI:10.1017/S0031182009006428


  7 / 9 MEDLINE  
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[PMID]:19126273
[Au] Autor:Knott ML; Hogan SP; Wang H; Matthaei KI; Dent LA
[Ad] Endereço:School of Molecular and Biomedical Science, University of Adelaide, Adelaide, South Australia, 5005, Australia.
[Ti] Título:FVB/N mice are highly resistant to primary infection with Nippostrongylus brasiliensis.
[So] Source:Parasitology;136(1):93-106, 2009 Jan.
[Is] ISSN:1469-8161
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Nippostrongylus brasiliensis larvae are particularly susceptible to immunological attack during the pre-lung stage of primary and secondary infections in mice. Whilst most of the common laboratory strains of mice are permissive hosts for the parasite, in this study we report for the first time, the strong resistance of naive FVB/N mice to N. brasiliensis. Damage to larvae is evident within the first 24 h of infection and this may be critical to later larval development and reproductive success. Inflammatory responses in the skin, and larval escape from this tissue were comparable in susceptible CBA/Ca and resistant FVB/N mice, with most larvae exiting within 4 h of a primary infection. Lung larval burdens were also similar between strains, but larvae recovered from FVB/N mice were smaller and less motile. In FVB/N mice, larval colonization of the gut was impaired and worms produced very few eggs. However FVB/N mice did not show enhanced resistance to Heligmosomoides bakeri (also known as Heligmosomoides polygyrus), a nematode largely restricted to the gut. Damage done in the pre-lung or lung stages of infection with N. brasiliensis is likely to contribute to ongoing developmental and functional abnormalities, which are profoundly evident in the gut phase of infection.
[Mh] Termos MeSH primário: Imunidade Inata/genética
Nippostrongylus/fisiologia
Infecções por Strongylida/genética
Infecções por Strongylida/imunologia
[Mh] Termos MeSH secundário: Animais
Proteínas de Ligação a Ácido Graxo/genética
Feminino
Imunidade Celular
Imunidade Inata/imunologia
Intestinos/parasitologia
Larva/fisiologia
Leucócitos/imunologia
Pulmão/parasitologia
Pulmão/patologia
Masculino
Camundongos
Camundongos Endogâmicos CBA
Camundongos Endogâmicos
Camundongos Transgênicos
Nematospiroides/fisiologia
Contagem de Ovos de Parasitas
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Fabp1 protein, mouse); 0 (Fatty Acid-Binding Proteins)
[Em] Mês de entrada:0901
[Cu] Atualização por classe:161118
[Lr] Data última revisão:
161118
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:090108
[St] Status:MEDLINE
[do] DOI:10.1017/S0031182008005192


  8 / 9 MEDLINE  
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[PMID]:17984274
[Au] Autor:Bordes F; Langand J; Feliu C; Morand S
[Ad] Endereço:UMR 5244, CNRS-EPHE-UPVD Biologie et Ecologie Tropicale et Mediterranéenne, CBETM Université, 52 Avenue Paul Alduy, 66860 Perpignan Cedex, France.
[Ti] Título:Helminth communities of an introduced hare (Lepus granatensis) and a native hare (Lepus europaeus) in southern France.
[So] Source:J Wildl Dis;43(4):747-51, 2007 Oct.
[Is] ISSN:0090-3558
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We investigated the parasite communities of introduced Iberian hares (Lepus granatensis) and native European hares (Lepus europaeus) in southern France, where Iberian hares were introduced locally 20 yr ago as a game animal. Parasite communities of sympatric populations of the two hare species and of allopatric populations of European hares were compared. Iberian hares in France harbored a depauperate community of parasites relative to the population in its native habitat in Spain. European hares in areas of sympatry also were infected by Nematodiroides zembrae, which normally infects Iberian hares on their native range.
[Mh] Termos MeSH primário: Lebres/parasitologia
Nematospiroides/isolamento & purificação
Infecções por Strongylida/veterinária
[Mh] Termos MeSH secundário: Animais
Feminino
França/epidemiologia
Lebres/classificação
Masculino
Nematospiroides/crescimento & desenvolvimento
Prevalência
Especificidade da Espécie
Infecções por Strongylida/epidemiologia
Infecções por Strongylida/patologia
Infecções por Strongylida/transmissão
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:0801
[Cu] Atualização por classe:071106
[Lr] Data última revisão:
071106
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:071107
[St] Status:MEDLINE


  9 / 9 MEDLINE  
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[PMID]:16118478
[Au] Autor:Naganuma T
[Ad] Endereço:Hiroshima University.
[Ti] Título:[Habitable zone].
[So] Source:Biol Sci Space;19(1):8-24, 2005 Mar.
[Is] ISSN:0914-9201
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Mh] Termos MeSH primário: Radiação Cósmica
Voo Espacial/instrumentação
Ausência de Peso
[Mh] Termos MeSH secundário: Animais
Artemia/efeitos da radiação
Bactérias/efeitos da radiação
Contenção de Riscos Biológicos
Poeira Cósmica
Drosophila melanogaster/efeitos da radiação
Insetos/efeitos da radiação
Larva/efeitos da radiação
Transferência Linear de Energia
Nematospiroides/efeitos da radiação
Quarentena
Dose de Radiação
Monitoramento de Radiação/instrumentação
Astronave
Esporos Bacterianos/efeitos da radiação
Tribolium/efeitos da radiação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cosmic Dust)
[Em] Mês de entrada:0509
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
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[Sb] Subgrupo de revista:S
[Da] Data de entrada para processamento:050825
[St] Status:MEDLINE



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BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde