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  1 / 605 MEDLINE  
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[PMID]:28803904
[Au] Autor:Gao JF; Liu GH; Duan H; Gao Y; Zhang Y; Chang QC; Fang M; Wang CR
[Ad] Endereço:College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing, Heilongjiang Province 163319, PR China; Department of Parasitology, Heilongjiang Institute of Veterinary Science, Qiqihar, Heilongjiang Province 161006, PR China. Electronic address: gaojunfeng_2005
[Ti] Título:Complete mitochondrial genomes of Triodontophorus serratus and Triodontophorus nipponicus, and their comparison with Triodontophorus brevicauda.
[So] Source:Exp Parasitol;181:88-93, 2017 Oct.
[Is] ISSN:1090-2449
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Triodontophorus serratus and Triodontophorus nipponicus are two of the most common nematodes inhabiting in the large intestine of horse. In the present study, the complete mitochondrial (mt) genome sequences of T. serratus and T. nipponicus have been determined. The mt genomes of T. serratus and T. nipponicus are circular molecules with 13,794 bp and 13,701 bp in size, respectively. These circular mt genomes encode 36 genes, including 12 protein-coding genes, two rRNA genes and 22 tRNA genes. All of these genes are transcribed in the same direction and gene arrangements are consistent with that of gene arrangement 3 (GA3-type). T. serratus and T. nipponicus had two non-coding regions, but T. brevicauda had three. Phylogenetic relationships were reconstructed using concatenated amino acid sequences of the 12 protein-coding genes with three methods, indicating that three species of Triodontophorus clustered together with strong statistical support. However, the genera of Strongylus and Triodontophorus belonged to Strongylinae do not cluster together, and Triodontophorus is more closely related to Cylicocyclus insigne, Cylicocyclus nassatus, Cylicostephanus goldi (Cyathostominae) than to Strongylus. The findings from the present study provide useful genetic markers for studying the molecular ecology, systematics, and population genetics of Triodontophorus in equine.
[Mh] Termos MeSH primário: Genoma Mitocondrial
Doenças dos Cavalos/parasitologia
Infecções por Strongylida/veterinária
Strongyloidea/genética
[Mh] Termos MeSH secundário: Animais
Composição de Bases
Ceco/parasitologia
Colo/parasitologia
DNA de Helmintos/química
DNA Mitocondrial/química
Ordem dos Genes
Genoma Mitocondrial/genética
Cavalos
Filogenia
Infecções por Strongylida/parasitologia
Strongyloidea/classificação
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Helminth); 0 (DNA, Mitochondrial)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170920
[Lr] Data última revisão:
170920
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170815
[St] Status:MEDLINE


  2 / 605 MEDLINE  
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[PMID]:28288767
[Au] Autor:Saumell C; Lifschitz A; Baroni R; Fusé L; Bistoletti M; Sagües F; Bruno S; Alvarez G; Lanusse C; Alvarez L
[Ad] Endereço:Laboratorio de Parasitología, Centro de Investigación Veterinaria de Tandil (CIVETAN), UNCPBA-CICPBA-CONICET, Facultad de Ciencias Veterinarias, UNCPBA, Campus Universitario, 7000 Tandil, Argentina.
[Ti] Título:The route of administration drastically affects ivermectin activity against small strongyles in horses.
[So] Source:Vet Parasitol;236:62-67, 2017 Mar 15.
[Is] ISSN:1873-2550
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The goal of the current study was to evaluate the comparative efficacy of ivermectin (IVM) against small strongyles (cyathostomins) following its oral and intramuscular (IM) administration, in naturally parasitized horses. The parasitological data were complemented with the assessment of the plasma disposition kinetics of IVM. The trial included two different experiments. In experiment I, 40 horses naturally infected with small strongyles were randomly allocated into four experimental groups (n=10) and treated with IVM (0.2mg/kg) as follows: IVM oral paste, animals were orally treated with Eqvalan (IVM 1.87% paste, as the reference formulation) by the oral route; IVM oral solution, animals were orally treated with Remonta (IVM 2% solution, as a test formulation); IVM IM solution, animals were IM treated with the test product (Remonta IVM 2% solution); and control, animals were kept without treatment as untreated controls. In experiment II, 24 horses naturally parasitized with small strongyles were randomly allocated into the same four experimental groups (n=6) described for experiment I. Faecal samples were individually collected directly from the rectum of each horse prior (day -1) and at 7 and 15 (Experiment I) or 7, 15 and 21 (Experiment II) days after-treatment, to assess the eggs per gram (epg) counts and estimate the efficacy of the treatments. Additionally, the comparative plasma disposition kinetics of IVM in treated animals was assessed in experiment II. In both experiments, an excellent (100%) IVM efficacy was observed after its oral administration (test and reference formulations). However, the IM administration of IVM resulted in a low efficacy (36-64%). Similar IVM plasma concentration was observed after its oral administration as a paste or as a solution. The higher IVM plasma profiles observed after the IM administration accounted for an enhanced systemic availability. The improved IVM efficacy observed against adult cyathostomins after its oral administration can be explained by an enhanced drug exposure of the worms located at the lumen of the large intestine. These findings may have a direct impact on the practical use of macrocyclic lactones in horses.
[Mh] Termos MeSH primário: Anti-Helmínticos/administração & dosagem
Ivermectina/administração & dosagem
Infecções Equinas por Strongyloidea/tratamento farmacológico
Strongyloidea/efeitos dos fármacos
[Mh] Termos MeSH secundário: Administração Oral
Animais
Anti-Helmínticos/farmacologia
Vias de Administração de Medicamentos/veterinária
Fezes/parasitologia
Cavalos
Injeções Intramusculares/veterinária
Ivermectina/farmacologia
Contagem de Ovos de Parasitas/veterinária
Strongyloidea/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Anthelmintics); 70288-86-7 (Ivermectin)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170908
[Lr] Data última revisão:
170908
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170315
[St] Status:MEDLINE


  3 / 605 MEDLINE  
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[PMID]:28288752
[Au] Autor:Nielsen MK; Lyons ET
[Ad] Endereço:M.H. Gluck Equine Research Center, Department of Veterinary Science, University of Kentucky, Lexington, KY, USA. Electronic address: martin.nielsen@uky.edu.
[Ti] Título:Encysted cyathostomin larvae in foals - progression of stages and the effect of seasonality.
[So] Source:Vet Parasitol;236:108-112, 2017 Mar 15.
[Is] ISSN:1873-2550
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Cyathostomins (small strongyles) are ubiquitous in grazing horses and are known pathogens as cause of larval cyathostominosis. As part of their life cycle, cyathostomin larvae invade the mucosal walls of the large intestines and undergo encystment. Newly ingested third stage larvae are known to undergo arrested development and this can lead to an accumulation of encysted burdens over the course of a grazing season. It is believed that the host immune system plays a significant role in triggering this arrestment. Little is known about the development and progression of larval stages in foals that are not expected to mount a pronounced immune response to ingested cyathostomin larvae. This study evaluated counts of encysted larvae measured in 37 foals. The foals were born in 2013, 2014, and 2015 into a parasitology research herd kept without anthelmintic intervention and were humanely euthanatized between 50 and 293days of age as part of an ongoing parasite transmission study. A mucosal digestion technique was performed to enumerate encysted early third stage (EL3) and late third stage/fourth stage (LL3/L4) larvae in the cecum, ventral colon and dorsal colon. Counts were analyzed statistically to evaluate the influence of foal age, sex, and seasonality on the counts. Total counts as well as LL3/L4 counts were significantly higher during the grazing season (March-November). Three defined age groups (>100, 100-200, >200days) did not have statistically different counts. Male foals had significantly higher total counts compared to females, and this has not been reported before. The study found that 41% of the recovered larvae were EL3s, but no indication of arrested development of these was observed. This indicates that cyathostomin infection in foals progresses in a manner substantially different from mature horses.
[Mh] Termos MeSH primário: Estações do Ano
Infecções Equinas por Strongyloidea/parasitologia
[Mh] Termos MeSH secundário: Fatores Etários
Animais
Ceco/parasitologia
Colo/parasitologia
Feminino
Cavalos
Larva/crescimento & desenvolvimento
Larva/fisiologia
Masculino
Estudos Retrospectivos
Strongyloidea/crescimento & desenvolvimento
Strongyloidea/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170908
[Lr] Data última revisão:
170908
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170315
[St] Status:MEDLINE


  4 / 605 MEDLINE  
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[PMID]:27915089
[Au] Autor:Gao Y; Qiu JH; Zhang BB; Su X; Fu X; Yue DM; Wang CR
[Ad] Endereço:College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing, Heilongjiang Province 163319, PR China. Electronic address: gaoyuangy89@126.com.
[Ti] Título:Complete mitochondrial genome of parasitic nematode Cylicocyclus nassatus and comparative analyses with Cylicocyclus insigne.
[So] Source:Exp Parasitol;172:18-22, 2017 Jan.
[Is] ISSN:1090-2449
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Cylicocyclus nassatus is a common and important parasite in the large intestine of equine. In this study, the complete mitochondrial (mt) genome sequence of C. nassatus was determined and comparatively analyzed with Cylicocyclus insigne. The mt genome size of C. nassatus was 13,846 bp, 18 bp longer than that of C. insigne. The circular mt genome includes 12 protein-coding genes, two rRNA genes, 22 tRNA genes and two non-coding regions. All the genes are transcribed in the same direction and gene arrangement is consistent with that of gene arrangement 3 (GA3). The overall sequence difference between the two complete mt genomes was 10.7%. For the 12 protein-coding genes, the comparison between C. nassatus and C. insigne revealed sequence divergence at both the nucleotide (6.3-13.0%) and amino acid (0.8-6.6%) levels. The nucleotide lengths of the 12 protein-coding genes were the same, except for cox3 which was longer in C. insigne. Phylogenetic analysis based on the concatenated amino acid sequence of the 12 protein-coding genes was performed using all the Strongylidae nematodes of the horse available in the GenBank. Phylogenetic analysis showed that C. nassatus and C. insigne clustered together with very high nodal support and the genus Cylicocyclus was closer to the genus Triodontophorus than to genus Strongylus. The mtDNA data determined in this study provides novel genetic markers for further studies on the identification, population genetics and molecular epidemiology of the genus Cylicocyclus.
[Mh] Termos MeSH primário: Genoma Mitocondrial
Strongyloidea/genética
[Mh] Termos MeSH secundário: Animais
DNA de Helmintos/genética
DNA Mitocondrial/genética
Ordem dos Genes
Genes de Helmintos
Genoma Helmíntico
Doenças dos Cavalos/parasitologia
Cavalos
Filogenia
Análise de Sequência de DNA
Infecções por Strongylida/parasitologia
Infecções por Strongylida/veterinária
Strongyloidea/classificação
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Helminth); 0 (DNA, Mitochondrial)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170206
[Lr] Data última revisão:
170206
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161205
[St] Status:MEDLINE


  5 / 605 MEDLINE  
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[PMID]:27938707
[Au] Autor:Daniels SP; Proudman CJ
[Ad] Endereço:School of Equine Management and Science, Royal Agricultural University, Cirencester, Gloucestershire GL7 6JS, UK; School of Veterinary Medicine, University of Surrey, Guildford, Surrey GU2 7TE, UK. Electronic address: simon.daniels@rau.ac.uk.
[Ti] Título:Shortened egg reappearance after ivermectin or moxidectin use in horses in the UK.
[So] Source:Vet J;218:36-39, 2016 Dec.
[Is] ISSN:1532-2971
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This study reports ivermectin and moxidectin egg reappearance periods (ERP) from UK horses with persistently positive faecal egg counts (FEC), defined as positive FEC within the ERP of an anthelmintic post-treatment, or with FECs that remained positive after the normal ERP post-anthelmintic treatment. A selected population of UK pleasure horses deemed at high risk of strongyle infection was studied. The earliest ERP recorded after ivermectin or moxidectin, using first positive FEC, was 5 weeks. From 16 premises where moxidectin was used, five had ERP ≥12 weeks using two further metrics. For premises where moxidectin was administered to only one animal (present or tested), and evaluated as one group (n = 61), ERP was ≥10 weeks. For premises where ivermectin was used, the ERP was ≥5 weeks. Premises with only one horse (present or tested), dosed with ivermectin (n = 31), analysed as one group, demonstrated egg reappearance ≥6 weeks. These field data suggest shortened ERPs following macrocyclic lactone treatment compared to previously published values (8-10 and >13 weeks respectively) when these drugs were first marketed.
[Mh] Termos MeSH primário: Antinematódeos/uso terapêutico
Óvulo/efeitos dos fármacos
Infecções Equinas por Strongyloidea/epidemiologia
Strongyloidea/fisiologia
[Mh] Termos MeSH secundário: Animais
Fezes/parasitologia
Feminino
Cavalos
Masculino
Contagem de Ovos de Parasitas/veterinária
Infecções Equinas por Strongyloidea/parasitologia
Infecções Equinas por Strongyloidea/prevenção & controle
Strongyloidea/efeitos dos fármacos
Reino Unido/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antinematodal Agents)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161213
[St] Status:MEDLINE


  6 / 605 MEDLINE  
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[PMID]:27905284
[Au] Autor:Avcioglu H; Güven E; Balkaya I; Yavuz S; Abay U; Akyüz M; Eltas Ö
[Ad] Endereço:Atatürk Üniversitesi Veteriner Fakültesi, Parazitoloji Anabilim Dali, Erzurum, Türkiye. balkayaibrahim@hotmail.com.
[Ti] Título:Parasites Determined by Fecal Examination in Horses in Erzurum.
[So] Source:Turkiye Parazitol Derg;40(3):147-151, 2016 Sep.
[Is] ISSN:2146-3077
[Cp] País de publicação:Turkey
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: This study aimed to determine the parasites present in horses belonging to the Erzurum Province. METHODS: Fecal samples were collected from 76 horses of different ages, genders and breeds in Erzurum. Individual fecal samples were collected and examined by flotation and sedimentation methods. RESULTS: The following species were detected: strongylid egg (57.89%), Parascaris equorum (10.52%), Dicrocoelium dendriticum (2.63%), Fasciola spp. (2.63%) eggs, and Eimeria spp. oocysts (5.26%). CONCLUSION: Equine animals are significantly infected with Strongylosis in the Erzurum Province, and effective parasite control measures should initiated.
[Mh] Termos MeSH primário: Doenças dos Cavalos/epidemiologia
Enteropatias Parasitárias/veterinária
[Mh] Termos MeSH secundário: Animais
Fezes/parasitologia
Feminino
Doenças dos Cavalos/parasitologia
Cavalos
Enteropatias Parasitárias/epidemiologia
Enteropatias Parasitárias/parasitologia
Masculino
Oocistos
Contagem de Ovos de Parasitas/veterinária
Infecções Equinas por Strongyloidea/epidemiologia
Infecções Equinas por Strongyloidea/parasitologia
Strongyloidea/isolamento & purificação
Turquia/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161202
[St] Status:MEDLINE
[do] DOI:10.5152/tpd.2016.4792


  7 / 605 MEDLINE  
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[PMID]:27692309
[Au] Autor:Scheuerle MC; Stear MJ; Honeder A; Becher AM; Pfister K
[Ad] Endereço:Comparative Tropical Medicine and Parasitology, Faculty of Veterinary Medicine, Ludwig-Maximilians-Universität, Leopoldstr. 5, D-80802 Munich, Germany. Electronic address: M.Scheuerle@lmu.de.
[Ti] Título:Repeatability of strongyle egg counts in naturally infected horses.
[So] Source:Vet Parasitol;228:103-107, 2016 Sep 15.
[Is] ISSN:1873-2550
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The selective treatment of horses is used to decrease the number of anthelmintic treatments by only treating a proportion of animals in the population. One way to select animals for treatment is to identify low and high egg-shedders using faecal egg counts (FEC); then to treat only the high egg-shedders. The value of this method is enhanced if differences among individuals in the level of egg-shedding remain consistent over time. One way to assess the stability of the rankings of animals over time is to measure the repeatability which is defined as the variance between horses divided by the total variance. The repeatability varies between 0 (no consistency in the values) to 1 (perfect consistency). To determine the repeatability of egg-shedding in naturally infected horses over time, 2637 FEC and raw egg counts (REC; i.e. originally counted eggs without multiplication factor) from 303 horses were analysed. The distribution of FEC was more overdispersed than a Poisson distribution. Therefore, a negative-binomial model was used. The within-horse-repeatability of RECs was 0.52. In a second analysis, we excluded horses that were treated with anthelmintic drugs during the study by eliminating all REC within the egg-reappearance-period. Here, the within-horse-repeatability was very similar at 0.53. The results show that egg-shedding of individual horses stays fairly consistent over time. They also show that animals which shed relatively high numbers of nematode eggs can be identified and targeted for treatment.
[Mh] Termos MeSH primário: Doenças dos Cavalos/diagnóstico
Infecções Equinas por Strongyloidea/diagnóstico
[Mh] Termos MeSH secundário: Animais
Anti-Helmínticos/uso terapêutico
Fezes/parasitologia
Feminino
Doenças dos Cavalos/tratamento farmacológico
Doenças dos Cavalos/parasitologia
Cavalos
Masculino
Modelos Estatísticos
Contagem de Ovos de Parasitas/veterinária
Reprodutibilidade dos Testes
Infecções Equinas por Strongyloidea/tratamento farmacológico
Infecções Equinas por Strongyloidea/parasitologia
Strongyloidea/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anthelmintics)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170807
[Lr] Data última revisão:
170807
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161004
[St] Status:MEDLINE


  8 / 605 MEDLINE  
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[PMID]:27692308
[Au] Autor:Gethings OJ; Sage RB; Morgan ER; Leather SR
[Ad] Endereço:Department of Crop & Environment Sciences, Harper Adams University, Edgmond, Newport, TF10 8NB, UK. Electronic address: owengethings@hotmail.co.uk.
[Ti] Título:Body condition is negatively associated with infection with Syngamus trachea in the ring-necked pheasant (Phasianus colchicus).
[So] Source:Vet Parasitol;228:1-5, 2016 Sep 15.
[Is] ISSN:1873-2550
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The role that parasites play in regulating animal populations is debated, however recent research hints at their pervasiveness among free-living animal populations. Parasites exert both direct and indirect effects on host populations, and can act to regulate populations. The Ring-necked pheasant is an important game-bird species in the UK, and large numbers of birds are released annually. The impact of the ubiquitous tracheal nematode, Syngamus trachea on pheasant populations through effects on host condition was assessed on two pheasant estates in the south west of England. Pheasants infected with S. trachea demonstrated a significant reduction in host condition compared with uninfected controls, with as few as one pair of worms per bird. Although there was no difference in worm burden between sexes, analysis of regression slopes revealed there was a significant difference between sexes in the magnitude of the effect of increasing worm burden on host condition, with detectable effects observed in hosts with one and three pairs of worms for males and females respectively. The observed reductions in host condition in birds with even sub-clinical infections could be the cause of poor reproductive success and survival of pheasants post-release.
[Mh] Termos MeSH primário: Doenças das Aves/parasitologia
Galliformes/parasitologia
Reprodução
Infecções por Strongylida/veterinária
Strongyloidea/fisiologia
[Mh] Termos MeSH secundário: Animais
Inglaterra
Feminino
Galliformes/fisiologia
Masculino
Infecções por Strongylida/parasitologia
Traqueia/parasitologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170807
[Lr] Data última revisão:
170807
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161004
[St] Status:MEDLINE


  9 / 605 MEDLINE  
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[PMID]:27581072
[Au] Autor:Love S; Burden FA; McGirr EC; Gordon L; Denwood MJ
[Ad] Endereço:School of Veterinary Medicine, University of Glasgow, Bearsden Road, Glasgow, G61 1QH, UK. Sandy.Love@Glasgow.ac.uk.
[Ti] Título:Equine Cyathostominae can develop to infective third-stage larvae on straw bedding.
[So] Source:Parasit Vectors;9:478, 2016 Aug 31.
[Is] ISSN:1756-3305
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Domesticated grazing animals including horses and donkeys are frequently housed using deep litter bedding systems, where it is commonly presumed that there is no risk of infection from the nematodes that are associated with grazing at pasture. We use two different approaches to test whether equids could become infected with cyathostomines from the ingestion of deep litter straw bedding. METHODS: Two herbage plot studies were performed in horticultural incubators set up to simulate three straw bedding scenarios and one grass turf positive control. Faeces were placed on 16 plots, and larval recoveries performed on samples of straw/grass substrate over 2- to 3-week periods. Within each incubator, a thermostat was set to maintain an environmental temperature of approximately 10 °C to 20 °C. To provide further validation, 24 samples of straw bedding were collected over an 8-week period from six barns in which a large number of donkeys were housed in a deep litter straw bedding system. These samples were collected from the superficial bedding at 16 sites along a "W" route through each barn. RESULTS: No infective larvae were recovered from any of the plots containing dry straw. However, infective cyathostomine larvae were first detected on day 8 from plots containing moist straw. In the straw bedding study, cyathostomine larvae were detected in 18 of the 24 samples. Additionally, in the two barns which were sampled serially, the level of larval infectivity generally increased from week to week, except when the straw bedding was removed and replaced. CONCLUSIONS: We have demonstrated that equine cyathostomines can develop to infective larvae on moist straw bedding. It is therefore possible for a horse or donkey bedded in deep litter straw to become infected by ingesting the contaminated straw. This has implications for parasite control in stabled equids and potentially in housed ruminants, and further investigation is required in order to establish the relative infective pressure from pasture versus straw bedding.
[Mh] Termos MeSH primário: Equidae
Pisos e Cobertura de Pisos
Caules de Planta
Poaceae
Infecções por Strongylida/veterinária
Strongyloidea/crescimento & desenvolvimento
[Mh] Termos MeSH secundário: Animais
Fezes/parasitologia
Abrigo para Animais
Larva/crescimento & desenvolvimento
Infecções por Strongylida/parasitologia
Temperatura Ambiente
Água
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
059QF0KO0R (Water)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160902
[St] Status:MEDLINE
[do] DOI:10.1186/s13071-016-1757-1


  10 / 605 MEDLINE  
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[PMID]:27523942
[Au] Autor:Kooyman FN; van Doorn DC; Geurden T; Mughini-Gras L; Ploeger HW; Wagenaar JA
[Ad] Endereço:Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, 3584 CL Utrecht, The Netherlands. Electronic address: f.n.j.kooyman@uu.nl.
[Ti] Título:Species composition of larvae cultured after anthelmintic treatment indicates reduced moxidectin susceptibility of immature Cylicocyclus species in horses.
[So] Source:Vet Parasitol;227:77-84, 2016 Aug 30.
[Is] ISSN:1873-2550
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:For the control of cyathostomins in horses, the macrocyclic lactones (MLs), moxidectin (MOX) and ivermectin (IVM) are the most commonly used anthelmintics. However, reduced activity, observed as shortening of the egg reappearance period (ERP) has been described. Shortening of the ERP may be caused by a decreased susceptibility of immature worms for MLs. Alternatively, immature worms may develop faster into egg producing adults as a result of repeated ML treatments. The species composition of the larval cultures obtained shortly after ML and pyrantel (PYR) treatment can confirm the hypothesis of decreased ML susceptibility, as this is often class-specific, whereas faster development would also occur after treatment with anthelmintics with a different mode of action. From 3 farms with a known history of shortened ERP, 8 horses per farm were selected and divided into 2 groups. The MOX-PYR-MOX group was treated twice with MOX (day 0 and 126) and once with PYR (day 84) and the IVM-PYR-IVM group was treated twice with IVM (day 0 and 98) and once with PYR (day 56). Cultured infective larvae (L3s) were counted and differentiated with the reverse line blot on pooled samples. Per cyathostomin species, the number of larvae per gram was calculated. The efficacy of all ML treatments was 100% and a shortened ERP was found on all 3 farms. The species composition of the larval cultures after ML treatment did not differ significantly from that after PYR treatment in the IVM-PYR-IVM group, but it did differ in the MOX-PYR-MOX group. The larval cultures obtained after MOX treatment consisted mostly of Cylicocyclus nassatus, while after PYR treatment Cylicostephanus longibursatus was the most abundant species. In the cultures from 42days after MOX treatment 6 cyathostomin species from 3 genera were found on the farm with the lowest activity (farm 1), while on the farm with the highest activity (farm 3) only 3 species from one genus were found in the same number of examined L3s. The high numbers of L3s of Cylicocyclus species 42days after MOX treatment and the low numbers 42days after PYR treatment can be explained by reduced susceptibility of the immature worms to MOX, but not by a faster development. In conclusion, shortening of the ERP following MOX treatment is most likely a process in which an increasing number of immature worms from an increasing number of species is becoming less susceptible to the active compound.
[Mh] Termos MeSH primário: Anti-Helmínticos/farmacologia
Resistência a Medicamentos
Macrolídeos/farmacologia
Infecções Equinas por Strongyloidea/parasitologia
Strongyloidea/isolamento & purificação
[Mh] Termos MeSH secundário: Animais
Cavalos
Larva/efeitos dos fármacos
Contagem de Ovos de Parasitas
Especificidade da Espécie
Infecções Equinas por Strongyloidea/tratamento farmacológico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anthelmintics); 0 (Macrolides); 51570-36-6 (milbemycin)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170501
[Lr] Data última revisão:
170501
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160816
[St] Status:MEDLINE



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