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  1 / 102 MEDLINE  
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[PMID]:28771620
[Au] Autor:Wegener Parfrey L; Jirku M; Síma R; Jalovecká M; Sak B; Grigore K; Jirku Pomajbíková K
[Ad] Endereço:Departments of Botany and Zoology, University of British Columbia, Vancouver, Canada.
[Ti] Título:A benign helminth alters the host immune system and the gut microbiota in a rat model system.
[So] Source:PLoS One;12(8):e0182205, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Helminths and bacteria are major players in the mammalian gut ecosystem and each influences the host immune system and health. Declines in helminth prevalence and bacterial diversity appear to play a role in the dramatic rise of immune mediated inflammatory diseases (IMIDs) in western populations. Helminths are potent modulators of immune system and their reintroduction is a promising therapeutic avenue for IMIDs. However, the introduction of helminths represents a disturbance for the host and it is important to understand the impact of helminth reintroduction on the host, including the immune system and gut microbiome. We tested the impact of a benign tapeworm, Hymenolepis diminuta, in a rat model system. We find that H. diminuta infection results in increased interleukin 10 gene expression in the beginning of the prepatent period, consistent with induction of a type 2 immune response. We also find induction of humoral immunity during the patent period, shown here by increased IgA in feces. Further, we see an immuno-modulatory effect in the small intestine and spleen in patent period, as measured by reductions in tissue immune cells. We observed shifts in microbiota community composition during the patent period (beta-diversity) in response to H. diminuta infection. However, these compositional changes appear to be minor; they occur within families and genera common to both treatment groups. There was no change in alpha diversity. Hymenolepis diminuta is a promising model for helminth therapy because it establishes long-term, stable colonization in rats and modulates the immune system without causing bacterial dysbiosis. These results suggest that the goal of engineering a therapeutic helminth that can safely manipulate the mammalian immune system without disrupting the rest of the gut ecosystem is in reach.
[Mh] Termos MeSH primário: Microbioma Gastrointestinal
Interações Hospedeiro-Parasita/imunologia
Hymenolepis diminuta/imunologia
Sistema Imunitário
Intestinos/microbiologia
Intestinos/parasitologia
Modelos Biológicos
[Mh] Termos MeSH secundário: Animais
Bactérias/classificação
Bactérias/isolamento & purificação
Biodiversidade
Fezes/química
Feminino
Regulação da Expressão Gênica/imunologia
Imunoglobulina A/análise
Imunoglobulina A/imunologia
Interleucina-10/genética
Interleucina-10/metabolismo
Filogenia
Ratos
Ratos Wistar
Baço/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Immunoglobulin A); 130068-27-8 (Interleukin-10)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170804
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0182205


  2 / 102 MEDLINE  
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[PMID]:28719332
[Au] Autor:Ahmad AF; Ngui R; Ong J; Sarip F; Ismail WHW; Omar H; Nor ZM; Amir A; Lim YAL; Mahmud R
[Ad] Endereço:Department of Parasitology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
[Ti] Título:Case Report: A Symptomatic Case of Infection in an Urban-Dwelling Adult in Malaysia.
[So] Source:Am J Trop Med Hyg;97(1):163-165, 2017 Jul.
[Is] ISSN:1476-1645
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A case of infection in a 43-year-old Malaysian male with persistent abdominal colicky pain is reported. Endoscopy revealed whitish worms in the lumen of the small intestine, which were identified as after microscopy. Patient was successfully treated with a single dose of praziquantel (25 mg/kg).
[Mh] Termos MeSH primário: Himenolepíase/diagnóstico
Hymenolepis diminuta/isolamento & purificação
Enteropatias Parasitárias/parasitologia
[Mh] Termos MeSH secundário: Adulto
Animais
Cidades
Seres Humanos
Himenolepíase/epidemiologia
Himenolepíase/parasitologia
Enteropatias Parasitárias/epidemiologia
Malásia/epidemiologia
Masculino
População Urbana
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170731
[Lr] Data última revisão:
170731
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170719
[St] Status:MEDLINE
[do] DOI:10.4269/ajtmh.15-0877


  3 / 102 MEDLINE  
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[PMID]:28689507
[Au] Autor:Panti-May JA; DE Andrade RRC; Gurubel-González Y; Palomo-Arjona E; Sodá-Tamayo L; Meza-Sulú J; Ramírez-Sierra M; Dumonteil E; Vidal-Martínez VM; Machaín-Williams C; DE Oliveira D; Reis MG; Torres-Castro MA; Robles MR; Hernández-Betancourt SF; Costa F
[Ad] Endereço:Doctorado en Ciencias Agropecuarias,Campus de Ciencias Biológicas y Agropecuarias,Universidad Autónoma de Yucatán,Merida,Mexico.
[Ti] Título:A survey of zoonotic pathogens carried by house mouse and black rat populations in Yucatan, Mexico.
[So] Source:Epidemiol Infect;145(11):2287-2295, 2017 08.
[Is] ISSN:1469-4409
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The house mouse (Mus musculus) and the black rat (Rattus rattus) are reservoir hosts for zoonotic pathogens, several of which cause neglected tropical diseases (NTDs). Studies of the prevalence of these NTD-causing zoonotic pathogens, in house mice and black rats from tropical residential areas are scarce. Three hundred and two house mice and 161 black rats were trapped in 2013 from two urban neighbourhoods and a rural village in Yucatan, Mexico, and subsequently tested for Trypanosoma cruzi, Hymenolepis diminuta and Leptospira interrogans. Using the polymerase chain reaction we detected T. cruzi DNA in the hearts of 4·9% (8/165) and 6·2% (7/113) of house mice and black rats, respectively. We applied the sedimentation technique to detect eggs of H. diminuta in 0·5% (1/182) and 14·2% (15/106) of house mice and black rats, respectively. Through the immunofluorescent imprint method, L. interrogans was identified in 0·9% (1/106) of rat kidney impressions. Our results suggest that the black rat could be an important reservoir for T. cruzi and H. diminuta in the studied sites. Further studies examining seasonal and geographical patterns could increase our knowledge on the epidemiology of these pathogens in Mexico and the risk to public health posed by rodents.
[Mh] Termos MeSH primário: Doença de Chagas/veterinária
Himenolepíase/veterinária
Leptospirose/veterinária
Camundongos
Ratos
Doenças dos Roedores/epidemiologia
[Mh] Termos MeSH secundário: Animais
Doença de Chagas/epidemiologia
Doença de Chagas/parasitologia
Reservatórios de Doenças/microbiologia
Reservatórios de Doenças/parasitologia
Meio Ambiente
Himenolepíase/epidemiologia
Himenolepíase/parasitologia
Hymenolepis diminuta/isolamento & purificação
Leptospira interrogans/isolamento & purificação
Leptospirose/epidemiologia
Leptospirose/microbiologia
México/epidemiologia
Prevalência
Doenças dos Roedores/microbiologia
Doenças dos Roedores/parasitologia
Roedores
Trypanosoma cruzi/isolamento & purificação
Zoonoses/epidemiologia
Zoonoses/microbiologia
Zoonoses/parasitologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171125
[Lr] Data última revisão:
171125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170711
[St] Status:MEDLINE
[do] DOI:10.1017/S0950268817001352


  4 / 102 MEDLINE  
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[PMID]:28219994
[Au] Autor:Pérez-Chacón G; Pocaterra LA; Rojas E; Hernán A; Jiménez JC; Núñez L
[Ad] Endereço:Cátedra de Parasitología, Escuela de Medicina "José María Vargas," Facultad de Medicina de la Universidad Central de Venezuela, Caracas, Venezuela.
[Ti] Título:Coinfection with , , , and Human Immunodeficiency Virus: A Case Report with Complex Immunologic Interactions.
[So] Source:Am J Trop Med Hyg;96(5):1094-1096, 2017 May.
[Is] ISSN:1476-1645
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:AbstractWe describe the case of a 43-year-old human immunodeficiency virus-infected man receiving combined antiretroviral therapy and coinfected with , , and , presenting as chronic diarrhea and critical weight loss. Immunological aspects of these interactions are reviewed.
[Mh] Termos MeSH primário: Diarreia/diagnóstico
Giardíase/diagnóstico
Infecções por HIV/diagnóstico
Himenolepíase/diagnóstico
[Mh] Termos MeSH secundário: Adulto
Animais
Anti-Helmínticos/uso terapêutico
Fármacos Anti-HIV/uso terapêutico
Antiprotozoários/uso terapêutico
Coinfecção
Diarreia/tratamento farmacológico
Diarreia/parasitologia
Diarreia/virologia
Giardia lamblia/efeitos dos fármacos
Giardia lamblia/crescimento & desenvolvimento
Giardíase/tratamento farmacológico
Giardíase/parasitologia
HIV/efeitos dos fármacos
HIV/crescimento & desenvolvimento
Infecções por HIV/tratamento farmacológico
Infecções por HIV/virologia
Seres Humanos
Himenolepíase/tratamento farmacológico
Himenolepíase/parasitologia
Hymenolepis diminuta/efeitos dos fármacos
Hymenolepis diminuta/crescimento & desenvolvimento
Hymenolepis nana/efeitos dos fármacos
Hymenolepis nana/crescimento & desenvolvimento
Masculino
Metronidazol/análogos & derivados
Metronidazol/uso terapêutico
Praziquantel/uso terapêutico
Tiazóis/uso terapêutico
Resultado do Tratamento
Perda de Peso
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anthelmintics); 0 (Anti-HIV Agents); 0 (Antiprotozoal Agents); 0 (Thiazoles); 140QMO216E (Metronidazole); 6490C9U457 (Praziquantel); R3459K699K (secnidazole); SOA12P041N (nitazoxanide)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170803
[Lr] Data última revisão:
170803
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170222
[St] Status:MEDLINE
[do] DOI:10.4269/ajtmh.16-0413


  5 / 102 MEDLINE  
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[PMID]:28192437
[Au] Autor:Aira N; Andersson AM; Singh SK; McKay DM; Blomgran R
[Ad] Endereço:Division of Medical Microbiology, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Linköping, Sweden.
[Ti] Título:Species dependent impact of helminth-derived antigens on human macrophages infected with Mycobacterium tuberculosis: Direct effect on the innate anti-mycobacterial response.
[So] Source:PLoS Negl Trop Dis;11(2):e0005390, 2017 Feb.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: In countries with a high prevalence of tuberculosis there is high coincident of helminth infections that might worsen disease outcome. While Mycobacterium tuberculosis (Mtb) gives rise to a pro-inflammatory Th1 response, a Th2 response is typical of helminth infections. A strong Th2 response has been associated with decreased protection against tuberculosis. PRINCIPAL FINDINGS: We investigated the direct effect of helminth-derived antigens on human macrophages, hypothesizing that helminths would render macrophages less capable of controlling Mtb. Measuring cytokine output, macrophage surface markers with flow cytometry, and assessing bacterial replication and phagosomal maturation revealed that antigens from different species of helminth directly affect macrophage responses to Mtb. Antigens from the tapeworm Hymenolepis diminuta and the nematode Trichuris muris caused an anti-inflammatory response with M2-type polarization, reduced macrophage phagosome maturation and ability to activate T cells, along with increased Mtb burden, especially in T. muris exposed cells which also induced the highest IL-10 production upon co-infection. However, antigens from the trematode Schistosoma mansoni had the opposite effect causing a decrease in IL-10 production, M1-type polarization and increased control of Mtb. CONCLUSION: We conclude that, independent of any adaptive immune response, infection with helminth parasites, in a species-specific manner can influence the outcome of tuberculosis by either enhancing or diminishing the bactericidal function of macrophages.
[Mh] Termos MeSH primário: Antígenos de Helmintos/imunologia
Imunidade Inata
Macrófagos/imunologia
Mycobacterium tuberculosis/imunologia
Tuberculose/imunologia
[Mh] Termos MeSH secundário: Animais
Bactérias/imunologia
Células Cultivadas
Citocinas/secreção
Citometria de Fluxo
Seres Humanos
Hymenolepis diminuta/imunologia
Proteínas de Membrana/análise
Viabilidade Microbiana
Fagossomos/metabolismo
Schistosoma mansoni/imunologia
Trichuris/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antigens, Helminth); 0 (Cytokines); 0 (Membrane Proteins)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170619
[Lr] Data última revisão:
170619
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170214
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0005390


  6 / 102 MEDLINE  
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[PMID]:27240605
[Au] Autor:Liu J; Morey RA; Wilson JK; Parker W
[Ad] Endereço:Department of Surgery,Duke University Medical Center,Durham, NC 27710,USA.
[Ti] Título:Practices and outcomes of self-treatment with helminths based on physicians' observations.
[So] Source:J Helminthol;91(3):267-277, 2017 May.
[Is] ISSN:1475-2697
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The successful use of helminths as therapeutic agents to resolve inflammatory disease was first recorded 40 years ago. Subsequent work in animal models and in humans has demonstrated that the organisms might effectively treat a wide range of inflammatory diseases, including allergies, autoimmune disorders and inflammation-associated neuropsychiatric disorders. However, available information regarding the therapeutic uses and effects of helminths in humans is limited. This study probes the practices and experiences of individuals 'self-treating' with helminths through the eyes of their physicians. Five physicians monitoring more than 700 self-treating patients were interviewed. The results strongly support previous indications that helminth therapy can effectively treat a wide range of allergies, autoimmune conditions and neuropsychiatric disorders, such as major depression and anxiety disorders. Approximately 57% of the self-treating patients observed by physicians in the study had autism. Physicians reported that the majority of patients with autism and inflammation-associated co-morbidities responded favourably to therapy with either of the two most popular organisms currently used by self-treaters, Hymenolepis diminuta and Trichuris suis. However, approximately 1% of paediatric patients experienced severe gastrointestinal pains with the use of H. diminuta, although the symptoms were resolved with an anti-helminthic drug. Further, exposure to helminths apparently did not affect the impaired comprehension of social situations that is the hallmark of autism. These observations point toward potential starting points for clinical trials, and provide further support for the importance of such trials and for concerted efforts aimed at probing the potential of helminths, and perhaps other biologicals, for therapeutic use.
[Mh] Termos MeSH primário: Terapia Biológica/métodos
Hymenolepis diminuta/crescimento & desenvolvimento
Inflamação/terapia
Autoadministração/métodos
Trichuris/crescimento & desenvolvimento
[Mh] Termos MeSH secundário: Animais
Seres Humanos
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170407
[Lr] Data última revisão:
170407
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160601
[St] Status:MEDLINE
[do] DOI:10.1017/S0022149X16000316


  7 / 102 MEDLINE  
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[PMID]:27672083
[Au] Autor:Reyes JL; Lopes F; Leung G; Mancini NL; Matisz CE; Wang A; Thomson EA; Graves N; Gilleard J; McKay DM
[Ad] Endereço:Gastrointestinal Research Group, Department of Physiology and Pharmacology, Calvin, Joan and Phoebe Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada joseluis611@yahoo.com.mx dmckay@ucalgary.ca.
[Ti] Título:Treatment with Cestode Parasite Antigens Results in Recruitment of CCR2+ Myeloid Cells, the Adoptive Transfer of Which Ameliorates Colitis.
[So] Source:Infect Immun;84(12):3471-3483, 2016 Dec.
[Is] ISSN:1098-5522
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Awareness of the immunological underpinnings of host-parasite interactions may reveal immune signaling pathways that could be used to treat inflammatory disease in humans. Previously we showed that infection with the rat tapeworm, Hymenolepis diminuta, used as a model helminth, or systemic delivery of worm antigen (HdAg) significantly reduced the severity of dinitrobenzene sulfonic acid (DNBS)-induced colitis in mice. Extending these analyses, intraperitoneal injection of HdAg dose-dependently suppressed dextran sodium sulfate (DSS)-induced colitis, and this was paralleled by reduced gamma interferon (IFN-γ), interleukin-17 (IL-17), and tumor necrosis factor alpha (TNF-α) production and increased IL-10 production from mitogen-activated splenocytes. Treatment with HdAg resulted in a CCR2-dependent recruitment of CDllb F4/80 Ly6C Gr-1 monocyte-like cells into the peritoneum 24 h later that were predominantly programmed death ligand 1 (PD-L1) positive and CXCR2 negative. In vitro assays indicated that these cells were unable to suppress T cell proliferation but enhanced IL-10 and IL-4 production from activated T cells. Adoptive transfer of the HdAg-recruited monocytic cells into naive mice blocked DSS-induced colitis. These findings add to the variety of means by which treatment with parasitic helminth-derived antigens can ameliorate concomitant disease. A precise understanding of the mechanism(s) of action of HdAg and other helminth-derived antigens (and a parallel consideration of putative side effects) may lead to the development of novel therapies for human idiopathic disorders such as inflammatory bowel disease.
[Mh] Termos MeSH primário: Transferência Adotiva
Antígenos de Helmintos
Colite/induzido quimicamente
Hymenolepis diminuta/metabolismo
Células Mieloides/fisiologia
[Mh] Termos MeSH secundário: Animais
Linfócitos T CD4-Positivos
Citocinas/genética
Citocinas/metabolismo
Sulfato de Dextrana/toxicidade
Regulação da Expressão Gênica
Masculino
Camundongos
Camundongos Endogâmicos BALB C
Camundongos Endogâmicos C57BL
Monócitos/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antigens, Helminth); 0 (Cytokines); 9042-14-2 (Dextran Sulfate)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170518
[Lr] Data última revisão:
170518
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160928
[St] Status:MEDLINE


  8 / 102 MEDLINE  
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[PMID]:27473838
[Au] Autor:Sharma S; Lyngdoh D; Roy B; Tandon V
[Ad] Endereço:Department of Zoology, North-Eastern Hill University, Shillong, 793022, Meghalaya, India.
[Ti] Título:Differential diagnosis and molecular characterization of Hymenolepis nana and Hymenolepis diminuta (Cestoda: Cyclophyllidea: Hymenolepididae) based on nuclear rDNA ITS2 gene marker.
[So] Source:Parasitol Res;115(11):4293-4298, 2016 Nov.
[Is] ISSN:1432-1955
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Given the widespread distribution and medical implication of members of the genus Hymenolepis, specific identification of the aetiological agent becomes imperative. For precise diagnosis of the species, molecular techniques such as PCR and RFLP of the nuclear ribosomal internal transcribed spacer 2 (rDNA-ITS2) gene marker were carried out. The results showed distinct restriction patterns for both Hymenolepis nana and Hymenolepis diminuta when digested with either of the enzymes RsaI, HaeIII or HhaI. The annotated rDNA-ITS2 sequences from the two species revealed differences in the length; the folded secondary structure also depicted clear demarcation between the two species with variations in length of the helices, pyrimidine-pyrimidine mismatches and sites where motifs occur. In phylogenetic analysis of the evolutionary relationship between the two species as well as with other members of the family Hymenolepididae, the species causing human hymenolepiasis were found to be distantly related as they diverged independently from the ancestral lineage.
[Mh] Termos MeSH primário: DNA Espaçador Ribossômico/genética
Himenolepíase/diagnóstico
Hymenolepis diminuta/genética
Hymenolepis nana/genética
[Mh] Termos MeSH secundário: Animais
Diagnóstico Diferencial
Marcadores Genéticos/genética
Seres Humanos
Himenolepíase/parasitologia
Filogenia
Reação em Cadeia da Polimerase
Polimorfismo de Fragmento de Restrição
Ratos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Ribosomal Spacer); 0 (Genetic Markers)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171007
[Lr] Data última revisão:
171007
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160731
[St] Status:MEDLINE


  9 / 102 MEDLINE  
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[PMID]:27466058
[Au] Autor:Kosik-Bogacka DI; Baranowska-Bosiacka I; Kolasa-Wolosiuk A; Lanocha-Arendarczyk N; Gutowska I; Korbecki J; Namieta H; Rotter I
[Ad] Endereço:Department of Biology and Medical Parasitology, Pomeranian Medical University, Szczecin, Poland. Electronic address: kodan@pum.edu.pl.
[Ti] Título:The inflammatory effect of infection with Hymenolepis diminuta via the increased expression and activity of COX-1 and COX-2 in the rat jejunum and colon.
[So] Source:Exp Parasitol;169:69-76, 2016 Oct.
[Is] ISSN:1090-2449
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The aim of this study was to determine whether Hymenolepis diminuta may affect the expression and activity of cyclooxygenase 1 (COX-1) and cyclooxygenase 2 (COX-2), resulting in the altered levels of their main products - prostaglandins (PGE2) and thromboxane B2 (TXB2). The study used the same experimental model as in our previous studies in which we had observed changes in the transepithelial ion transport, tight junctions and in the indicators of oxidative stress, in both small and large intestines of rats infected with H. diminuta. In this paper, we investigated not only the site of immediate presence of the tapeworm (jejunum), but also a distant site (colon). Inflammation related to H. diminuta infection is associated with the increased expression and activation of cyclooxygenase (COX), enzyme responsible for the synthesis of PGE2 and TXB2, local hormones contributing to the enhanced inflammatory reaction in the jejunum and colon in the infected rats. The increased COX expression and activity is probably caused by the increased levels of free radicals and the weakening of the host's antioxidant defense induced by the presence of the parasite. Our immunohistochemical analysis showed that H. diminuta infection affected not only the intensity of the immunodetection of COX but also the enzyme protein localization within intestinal epithelial cells - from the entire cytoplasm to apical/basal regions of cells, or even to the nucleus.
[Mh] Termos MeSH primário: Colo/enzimologia
Ciclo-Oxigenase 1/metabolismo
Ciclo-Oxigenase 2/metabolismo
Himenolepíase/enzimologia
Hymenolepis diminuta/fisiologia
Jejuno/enzimologia
[Mh] Termos MeSH secundário: Animais
Western Blotting
Colo/parasitologia
Dinoprostona/metabolismo
Himenolepíase/parasitologia
Himenolepíase/patologia
Imuno-Histoquímica
Inflamação
Jejuno/parasitologia
Masculino
Ratos
Ratos Wistar
Tromboxano B2/metabolismo
Tribolium
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
54397-85-2 (Thromboxane B2); EC 1.14.99.1 (Cyclooxygenase 1); EC 1.14.99.1 (Cyclooxygenase 2); K7Q1JQR04M (Dinoprostone)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170215
[Lr] Data última revisão:
170215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160729
[St] Status:MEDLINE


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[PMID]:27344656
[Au] Autor:Jankovská I; Sloup V; Száková J; Langrová I; Sloup S
[Ad] Endereço:Department of Zoology and Fisheries, Faculty of Agrobiology, Food and Natural Resources, Czech University of Life Sciences Prague, Kamycka 957, 16521, Prague 6 - Suchdol, Czech Republic. jankovska@af.czu.cz.
[Ti] Título:How the tapeworm Hymenolepis diminuta affects zinc and cadmium accumulation in a host fed a hyperaccumulating plant (Arabidopsis halleri).
[So] Source:Environ Sci Pollut Res Int;23(19):19126-33, 2016 Oct.
[Is] ISSN:1614-7499
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The effects of plant-bound zinc (Zn) and cadmium (Cd) on element uptake and their interactions in a parasite-host system were investigated in a model experiment. Male Wistar rats were divided into four groups (C, P, TC and TP). Groups TC and TP were infected with the rat tapeworm Hymenolepis diminuta. Groups C and TC were fed a standard rodent mixture (ST-1) and received 10.5 mg of Zn per week, while groups P and TP were fed a mixture supplemented with the Zn- and Cd-hyperaccumulating plant Arabidopsis halleri at a dosage of 236 mg Zn/week and 3.0 mg Cd/week. Rats were euthanized after 6 weeks, and Cd and Zn levels were determined in rat and tapeworm tissue. The results indicate that tapeworm presence did have an effect on Cd and Zn concentrations in the host tissue; the majority of tissues in infected rats had statistically significant lower Zn and Cd concentrations than did uninfected rats. Tapeworms accumulated more zinc and cadmium than did the majority of host tissues. This important finding confirms the ability of tapeworms to accumulate certain elements (heavy metals) from the host body to their own body tissues. Thus, tapeworms can decrease heavy metal concentrations in host tissues.
[Mh] Termos MeSH primário: Arabidopsis/química
Cádmio/metabolismo
Hymenolepis diminuta/fisiologia
Zinco/metabolismo
[Mh] Termos MeSH secundário: Animais
Arabidopsis/efeitos dos fármacos
Cádmio/farmacologia
Dieta
Masculino
Metais Pesados/metabolismo
Metais Pesados/farmacologia
Ratos
Ratos Wistar
Zinco/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Metals, Heavy); 00BH33GNGH (Cadmium); J41CSQ7QDS (Zinc)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160627
[St] Status:MEDLINE
[do] DOI:10.1007/s11356-016-7123-1



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