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  1 / 1992 MEDLINE  
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[PMID]:28467600
[Au] Autor:Arora N; Tripathi S; Kumar P; Mondal P; Mishra A; Prasad A
[Ad] Endereço:School of Basic Sciences, Indian Institute of Technology Mandi, Mandi, India.
[Ti] Título:Recent advancements and new perspectives in animal models for Neurocysticercosis immunopathogenesis.
[So] Source:Parasite Immunol;39(7), 2017 Jul.
[Is] ISSN:1365-3024
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Neurocysticercosis (NCC), one of the most common parasitic diseases of the central nervous system, is caused by Taenia solium. This parasite involves two hosts, intermediate hosts (pig and human) and a definitive host (human) and has various stages in its complex life cycle (eggs, oncosphere, cysticerci and adult tapeworm). Hence, developing an animal model for T. solium that mimics its natural course of infection is quite challenging. We have reviewed here the animal models frequently used to study immunopathogenesis of cysticercosis and also discussed their usefulness for NCC studies. We found that researchers have used mice, rats, guinea pigs, dogs, cats and pigs as models for this disease with varying degrees of success. Mice and rats models have been utilized extensively for immunopathogenesis studies due to their relative ease of handling and abundance of commercially available reagents to study these small animal models. These models have provided some very exciting results for in-depth understanding of the disease. Of late, the experimentally/naturally infected swine model is turning out to be the best animal model as the disease progression closely resembles human infection in pigs. However, handling large experimental animals has its own challenges and limitations.
[Mh] Termos MeSH primário: Modelos Animais de Doenças
Neurocisticercose/imunologia
Taenia solium/imunologia
Taenia/imunologia
Teníase/imunologia
[Mh] Termos MeSH secundário: Animais
Chinchila
Cricetinae
Seres Humanos
Estágios do Ciclo de Vida
Macaca mulatta
Neurocisticercose/parasitologia
Ratos
Suínos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171228
[Lr] Data última revisão:
171228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE
[do] DOI:10.1111/pim.12439


  2 / 1992 MEDLINE  
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[PMID]:28902284
[Au] Autor:Paknezhad N; Mazdarani FH; Hessari M; Mobedi I; Najafi F; Bizhani N; Makki M; Hassanpour G; Mowlavi G
[Ad] Endereço:Tehran University of Medical Sciences, Department of Parasitology and Mycology, School of Public Health, Tehran, Iran.
[Ti] Título:Retrieving ascarid and taeniid eggs from the biological remains of a Neolithic dog from the late 9th millennium BC in Western Iran.
[So] Source:Mem Inst Oswaldo Cruz;112(9):593-595, 2017 Sep.
[Is] ISSN:1678-8060
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Paleoparasitology reveals the status of parasitic infections in humans and animals in ancient times based on parasitic particles found in biological remains from archaeological excavations. This line of research emerged in Iran in 2013. OBJECTIVE: The identification of parasites from Neolithic times is an attractive subject that shows the oldest origins of parasitic infections in a given geographical region. From an archaeological point of view, this archaeological site is well-known for animal domestication and agriculture in ancient Iran. METHODS: In this study, soil deposited on the surface and in the pores of a dog pelvic bone was carefully collected and rehydrated using trisodium phosphate solution. FINDINGS: The results showed ascarid and taeniid eggs retrieved from the biological remains of a dog excavated at the East Chia Sabz archaeological site, which dates back to the Neolithic period (8100 BC). MAIN CONCLUSION: The current findings clearly illustrate the natural circulation of nematode and cestode parasites among dogs at that time. These ancient helminth eggs can also be used to track the oldest parasitic infections in the Iranian plateau and contribute to the paleoparasitological documentation of the Fertile Crescent.
[Mh] Termos MeSH primário: Ascaridia/isolamento & purificação
Cães/parasitologia
Fósseis
Óvulo
Paleopatologia
Taenia/isolamento & purificação
[Mh] Termos MeSH secundário: Animais
História Antiga
Irã (Geográfico)
Solo/parasitologia
[Pt] Tipo de publicação:HISTORICAL ARTICLE; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Soil)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170914
[St] Status:MEDLINE


  3 / 1992 MEDLINE  
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[PMID]:28876418
[Au] Autor:Shamsaddini S; Mohammadi MA; Mirbadie SR; Rostami S; Dehghani M; Sadeghi B; Harandi MF
[Ad] Endereço:Kerman University of Medical Sciences, Research Center for Hydatid Disease in Iran, Kerman, Iran.
[Ti] Título:A conventional PCR for differentiating common taeniid species of dogs based on in silico microsatellite analysis.
[So] Source:Rev Inst Med Trop Sao Paulo;59:e66, 2017 Sep 04.
[Is] ISSN:1678-9946
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:Canine taeniids are among the major tapeworms with remarkable medical and economic significance. Reliable diagnosis and differentiation of dog taeniids using simple and sensitive tools are of paramount importance for establishing an efficient surveillance system. Microsatellites as abundant unique tandem repeats of short DNA motifs are useful genetic markers for molecular epidemiological studies. The purpose of the present study was to find a primer pair for rapid differentiation of major tapeworms of dogs, Taenia hydatigena, T. multiceps, T. ovis and Echinococcus granulosus, by screening existing nucleotide data. All the mitochondrial genome records as well as non-coding ITS1 sequences of Taeniidae species were downloaded from Nucleotide database from NCBI. For prediction and analysis of potential loci of STR/SSR in ITS1 as well as mitochondrial regions, we used ChloroMitoSSRDB 2.0 and GMATo v1.2. software. Different tapeworm species were categorized according to different motif sequences and type and size of each microsatellite locus. Three primer sets were designed and tested for differentiating taeniid species and evaluated in a conventional PCR system. Four taeniid species were successfully differentiated using a primer pair in a simple conventional PCR system. We predicted 2-19 and 1-4 microsatellite loci in ITS1 and mitochondrial genome, respectively. In ITS1, 41 Di and 21 Tri motifs were found in the taeniids while the majority of the motifs in the mitochondrial genome were Tetra (89) and Tri (70). It is documented that the number and diversity of microsatellite loci is higher in nuclear ITS1 region than mostly coding mitochondrial genome.
[Mh] Termos MeSH primário: Primers do DNA/genética
Cães/parasitologia
Repetições de Microssatélites
Taenia/genética
[Mh] Termos MeSH secundário: Animais
Mitocôndrias/genética
Reação em Cadeia da Polimerase
Ovinos/parasitologia
Taenia/classificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA Primers)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171005
[Lr] Data última revisão:
171005
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170907
[St] Status:MEDLINE


  4 / 1992 MEDLINE  
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[PMID]:28704366
[Au] Autor:Schneider-Crease I; Griffin RH; Gomery MA; Dorny P; Noh JC; Handali S; Chastain HM; Wilkins PP; Nunn CL; Snyder-Mackler N; Beehner JC; Bergman TJ
[Ad] Endereço:Department of Evolutionary Anthropology, Duke University, Durham, North Carolina, United States of America.
[Ti] Título:Identifying wildlife reservoirs of neglected taeniid tapeworms: Non-invasive diagnosis of endemic Taenia serialis infection in a wild primate population.
[So] Source:PLoS Negl Trop Dis;11(7):e0005709, 2017 Jul.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Despite the global distribution and public health consequences of Taenia tapeworms, the life cycles of taeniids infecting wildlife hosts remain largely undescribed. The larval stage of Taenia serialis commonly parasitizes rodents and lagomorphs, but has been reported in a wide range of hosts that includes geladas (Theropithecus gelada), primates endemic to Ethiopia. Geladas exhibit protuberant larval cysts indicative of advanced T. serialis infection that are associated with high mortality. However, non-protuberant larvae can develop in deep tissue or the abdominal cavity, leading to underestimates of prevalence based solely on observable cysts. We adapted a non-invasive monoclonal antibody-based enzyme-linked immunosorbent assay (ELISA) to detect circulating Taenia spp. antigen in dried gelada urine. Analysis revealed that this assay was highly accurate in detecting Taenia antigen, with 98.4% specificity, 98.5% sensitivity, and an area under the curve of 0.99. We used this assay to investigate the prevalence of T. serialis infection in a wild gelada population, finding that infection is substantially more widespread than the occurrence of visible T. serialis cysts (16.4% tested positive at least once, while only 6% of the same population exhibited cysts). We examined whether age or sex predicted T. serialis infection as indicated by external cysts and antigen presence. Contrary to the female-bias observed in many Taenia-host systems, we found no significant sex bias in either cyst presence or antigen presence. Age, on the other hand, predicted cyst presence (older individuals were more likely to show cysts) but not antigen presence. We interpret this finding to indicate that T. serialis may infect individuals early in life but only result in visible disease later in life. This is the first application of an antigen ELISA to the study of larval Taenia infection in wildlife, opening the doors to the identification and description of infection dynamics in reservoir populations.
[Mh] Termos MeSH primário: Doenças Endêmicas
Ensaio de Imunoadsorção Enzimática/métodos
Doenças dos Primatas/diagnóstico
Doenças dos Primatas/epidemiologia
Taenia/isolamento & purificação
Teníase/veterinária
Urina/parasitologia
[Mh] Termos MeSH secundário: Animais
Antígenos de Helmintos/urina
Etiópia/epidemiologia
Feminino
Masculino
Prevalência
Curva ROC
Sensibilidade e Especificidade
Teníase/diagnóstico
Teníase/epidemiologia
Theropithecus/parasitologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antigens, Helminth)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171121
[Lr] Data última revisão:
171121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170714
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0005709


  5 / 1992 MEDLINE  
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[PMID]:28665952
[Au] Autor:Lovera R; Fernández MS; Jacob J; Lucero N; Morici G; Brihuega B; Farace MI; Caracostantogolo J; Cavia R
[Ad] Endereço:Departamento de Ecología, Genética y Evolución, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires and Instituto de Ecología, Genética y Evolución de Buenos Aires (IEGEBA), UBA-CONICET, Cdad. Autónoma de Buenos Aires, Argentina.
[Ti] Título:Intrinsic and extrinsic factors related to pathogen infection in wild small mammals in intensive milk cattle and swine production systems.
[So] Source:PLoS Negl Trop Dis;11(6):e0005722, 2017 Jun.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Understanding the ecological processes that are involved in the transmission of zoonotic pathogens by small mammals may aid adequate and effective management measures. Few attempts have been made to analyze the ecological aspects that influence pathogen infection in small mammals in livestock production systems. We describe the infection of small mammals with Leptospira spp., Brucella spp., Trichinella spp. and Cysticercus fasciolaris and assess the related intrinsic and extrinsic factors in livestock production systems in central Argentina at the small mammal community, population and individual levels. METHODOLOGY/PRINCIPAL FINDINGS: Ten pig farms and eight dairy farms were studied by removal trapping of small mammals from 2008 to 2011. Each farm was sampled seasonally over the course of one year with cage and Sherman live traps. The 505 small mammals captured (14,359 trap-nights) included three introduced murine rodents, four native rodents and two opossums. Leptospira spp., anti-Brucella spp. antibodies and Trichinella spp. were found in the three murine rodents and both opossums. Rattus norvegicus was also infected with C. fasciolaris; Akodon azarae and Oligoryzomys flavescens with Leptospira spp.; anti-Brucella spp. antibodies were found in A. azarae. Two or more pathogens occurred simultaneously on 89% of the farms, and each pathogen was found on at least 50% of the farms. Pathogen infections increased with host abundance. Infection by Leptospira spp. also increased with precipitation and during warm seasons. The occurrence of anti-Brucella spp. antibodies was higher on dairy farms and during the winter and summer. The host abundances limit values, from which farms are expected to be free of the studied pathogens, are reported. CONCLUSIONS/SIGNIFICANCE: Murine rodents maintain pathogens within farms, whereas other native species are likely dispersing pathogens among farms. Hence, we recommend preventing and controlling murines in farm dwellings and isolating farms from their surroundings to avoid contact with other wild mammals.
[Mh] Termos MeSH primário: Infecções Bacterianas/veterinária
Gambás/microbiologia
Gambás/parasitologia
Doenças Parasitárias em Animais/epidemiologia
Roedores/microbiologia
Roedores/parasitologia
[Mh] Termos MeSH secundário: Animais
Anticorpos Antibacterianos/sangue
Argentina
Infecções Bacterianas/epidemiologia
Brucella/imunologia
Bovinos
Fazendas
Leptospira/isolamento & purificação
Prevalência
Suínos
Taenia/isolamento & purificação
Trichinella/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Bacterial)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170808
[Lr] Data última revisão:
170808
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170701
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0005722


  6 / 1992 MEDLINE  
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[PMID]:28483730
[Au] Autor:Öge H; Öge S; Özbakis G; Gürcan IS
[Ad] Endereço:Ankara Üniversitesi Veteriner Fakültesi, Parazitoloji Anabilim Dali, Ankara, Türkiye. hoge@ankara.edu.tr.
[Ti] Título:Helminth Infections by Coprological Examination in Sheep-Dogs and Their Zoonotic Importance.
[So] Source:Turkiye Parazitol Derg;41(1):22-27, 2017 Mar.
[Is] ISSN:2146-3077
[Cp] País de publicação:Turkey
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: This study was conducted to determine the prevalence of gastrointestinal helminths and diagnose the species of important zoonotic helminths in sheep dogs. METHODS: Firstly, fecal samples were macroscopically examined; subsequently, formalin-ethyl acetate sedimentation and ZnSO4 centrifugal floatation techniques were applied for the examination of helminth eggs. PCR technique was utilized to determine the species of E. granulosus and T. canis in dogs found positive for Taenia spp. and Toxocara spp. RESULTS: Helminth infection was detected in 35.26% of sheep dogs. Taenia spp. was the most common helminth (12.05%), followed by Toxocara spp. (9.38%), Toxascaris leonina (6.25%), and Trichuris spp. (4.2%). The positive results in the E. granulosus and T. canis-specific PCR-based molecular tests were obtained in 14 of the Taenia egg-positive samples and in 5 of the Toxocara egg-positive samples from dogs. This study has suggested that coprophagy and feed raw offal and meat to dogs may be responsible for finding atypical helminth eggs in fecal samples from dogs in the absence of an actual infection. CONCLUSION: To make the diagnosis of their owned parasites of dogs, E. granulosus and T. canis which have zoonotic importance, feces must be examined by both conventional and copro-PCR techniques. In addition to dogs' feeding habits, other related factors must be taken into account in the epidemiology of helminth infection; thus, precaution and control measures will be more reliable.
[Mh] Termos MeSH primário: Doenças do Cão/epidemiologia
Doenças do Cão/parasitologia
Fezes/parasitologia
Helmintíase Animal/epidemiologia
Helmintos/isolamento & purificação
[Mh] Termos MeSH secundário: Animais
Cães
Echinococcus granulosus/isolamento & purificação
Helmintíase Animal/parasitologia
Helmintos/classificação
Reação em Cadeia da Polimerase/veterinária
Prevalência
Ovinos
Taenia/isolamento & purificação
Toxascaris/isolamento & purificação
Toxocara/isolamento & purificação
Trichuris/isolamento & purificação
Turquia
Zoonoses/parasitologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171108
[Lr] Data última revisão:
171108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170510
[St] Status:MEDLINE
[do] DOI:10.5152/tpd.2017.5123


  7 / 1992 MEDLINE  
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[PMID]:28443983
[Au] Autor:Slepchenko SM; Ivanov SN; Vybornov AV; Alekseevich TA; Sergeyevich SV; Lysenko DN; Matveev VE
[Ad] Endereço:Ltd Paleopoisk, Novosibirsk, Russia.
[Ti] Título:Taenia sp. in human burial from Kan River, East Siberia.
[So] Source:Mem Inst Oswaldo Cruz;112(5):387-390, 2017 May.
[Is] ISSN:1678-8060
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:We present an arhaeoparasitological analysis of a unique burial from the Neftprovod II burial ground in East Siberia, which dated from the Bronze Age. Analysis of a sediment sample from the sacral region of the pelvis revealed the presence of Taenia sp. eggs. Because uncooked animal tissue is the primary source of Taenia, this indicated that the individual was likely consuming raw or undercooked meat of roe deer, red deer, or elk infected with Taenia. This finding represents the oldest case of a human infected with Taenia sp. from Eastern Siberia and Russia.
[Mh] Termos MeSH primário: Paleopatologia
Taenia/isolamento & purificação
[Mh] Termos MeSH secundário: Animais
Sepultamento
História Antiga
Seres Humanos
Rios
Sibéria
[Pt] Tipo de publicação:HISTORICAL ARTICLE; JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170824
[Lr] Data última revisão:
170824
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170427
[St] Status:MEDLINE


  8 / 1992 MEDLINE  
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[PMID]:28410387
[Au] Autor:Alva A; Cangalaya C; Quiliano M; Krebs C; Gilman RH; Sheen P; Zimic M
[Ad] Endereço:Unidad de Bioinformática, Laboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Perú.
[Ti] Título:Mathematical algorithm for the automatic recognition of intestinal parasites.
[So] Source:PLoS One;12(4):e0175646, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Parasitic infections are generally diagnosed by professionals trained to recognize the morphological characteristics of the eggs in microscopic images of fecal smears. However, this laboratory diagnosis requires medical specialists which are lacking in many of the areas where these infections are most prevalent. In response to this public health issue, we developed a software based on pattern recognition analysis from microscopi digital images of fecal smears, capable of automatically recognizing and diagnosing common human intestinal parasites. To this end, we selected 229, 124, 217, and 229 objects from microscopic images of fecal smears positive for Taenia sp., Trichuris trichiura, Diphyllobothrium latum, and Fasciola hepatica, respectively. Representative photographs were selected by a parasitologist. We then implemented our algorithm in the open source program SCILAB. The algorithm processes the image by first converting to gray-scale, then applies a fourteen step filtering process, and produces a skeletonized and tri-colored image. The features extracted fall into two general categories: geometric characteristics and brightness descriptions. Individual characteristics were quantified and evaluated with a logistic regression to model their ability to correctly identify each parasite separately. Subsequently, all algorithms were evaluated for false positive cross reactivity with the other parasites studied, excepting Taenia sp. which shares very few morphological characteristics with the others. The principal result showed that our algorithm reached sensitivities between 99.10%-100% and specificities between 98.13%- 98.38% to detect each parasite separately. We did not find any cross-positivity in the algorithms for the three parasites evaluated. In conclusion, the results demonstrated the capacity of our computer algorithm to automatically recognize and diagnose Taenia sp., Trichuris trichiura, Diphyllobothrium latum, and Fasciola hepatica with a high sensitivity and specificity.
[Mh] Termos MeSH primário: Algoritmos
Helmintíase/diagnóstico
[Mh] Termos MeSH secundário: Animais
Difilobotríase/diagnóstico
Diphyllobothrium/crescimento & desenvolvimento
Fasciola hepatica/crescimento & desenvolvimento
Fasciolíase/diagnóstico
Seres Humanos
Processamento de Imagem Assistida por Computador
Microscopia
Óvulo/patologia
Reconhecimento Automatizado de Padrão
Sensibilidade e Especificidade
Taenia/crescimento & desenvolvimento
Teníase/diagnóstico
Tricuríase/diagnóstico
Trichuris/crescimento & desenvolvimento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170504
[Lr] Data última revisão:
170504
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170415
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0175646


  9 / 1992 MEDLINE  
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[PMID]:28394979
[Au] Autor:Cardona-Arias JA; Carrasquilla-Agudelo YE; Restrepo-Posada DC
[Ad] Endereço:Grupo de investigación Salud y Sostenibilidad, Escuela de Microbiología, Universidad de Antioquia, Medellín, Colombia.
[Ti] Título:[Validity of three methods for inmuno-diagnostic of neurocysticercosis: systematic review of the literature with meta-analysis 1960-2014].
[Ti] Título:Validez de tres métodos de inmuno-diagnóstico de neurocisticercosis: revisión sistemática de la literatura con meta-análisis 1960-2014..
[So] Source:Rev Chilena Infectol;34(1):33-44, 2017 Feb.
[Is] ISSN:0717-6341
[Cp] País de publicação:Chile
[La] Idioma:spa
[Ab] Resumo:INTRODUCTION: The screening of neurocysticercosis is complex and immunological methods have varying validity. OBJECTIVE: To evaluate the validity of ELISA for antigen and antibody, and EITB for antibody in the screening of neurocysticercosis. METHODS: Meta-analysis of diagnostic tests with an ex-ante protocol implemented in five databases with 15 search strategies, ensuring reproducibility in the selection and extraction of information. Sensitivity, specificity, likelihood ratios (LR), diagnostic odds ratio and ROC curve were estimated in MetaDiSc, and predictive values, and Youden index were estimated in Epidat. RESULTS: EITB presented sensitivity of 85.7% (95% CI 83.5-87.7), specificity 93.9% (95% CI = 92.7-95.0), PLR 19.6 (95% CI = 8,6-44.6), NLR 0.16 (95% CI = 0.12-0.21), OR diagnostic 136.2 (95% CI = 54.7-342.6) and area under the curve 0.926. In ELISA for antibody sensitivity was 87.5% (95% CI = 86.1-88.8), specificity 92.2% (95% CI = 91.4-93.0), PLR 11.3 (95% CI = 8.45-15.11), NLR 0.15 (95% CI = 0.13-0.18), diagnostic OR 87.4 (95% CI = 60.1-127.1) and area under the curve 0.950. ELISA for antigen showed low diagnostic validity. No differences were found in these parameters by sample, antigen or antibody type. CONCLUSION: ELISA for antibodies and EITB have a similar diagnostic value, detection of serum and CSF showed a similar validity.
[Mh] Termos MeSH primário: Anticorpos Anti-Helmínticos/sangue
Antígenos de Helmintos/imunologia
Técnicas Imunoenzimáticas/métodos
Neurocisticercose/diagnóstico
Taenia/imunologia
[Mh] Termos MeSH secundário: Animais
Ensaio de Imunoadsorção Enzimática
Curva ROC
Reprodutibilidade dos Testes
Sensibilidade e Especificidade
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; REVIEW; VALIDATION STUDIES
[Nm] Nome de substância:
0 (Antibodies, Helminth); 0 (Antigens, Helminth)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170814
[Lr] Data última revisão:
170814
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170411
[St] Status:MEDLINE


  10 / 1992 MEDLINE  
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[PMID]:28301259
[Au] Autor:Vera-Aguilera J; Perez-Torres A; Beltran D; Villanueva-Ramos C; Wachtel M; Moreno-Aguilera E; Vera-Aguilera C; Ventolini G; Martínez-Zaguilán R; Sennoune SR
[Ad] Endereço:1 Division of Hematology, Mayo Clinic , Rochester, Minnesota.
[Ti] Título:Novel Treatment of Melanoma: Combined Parasite-Derived Peptide GK-1 and Anti-Programmed Death Ligand 1 Therapy.
[So] Source:Cancer Biother Radiopharm;32(2):49-56, 2017 Mar.
[Is] ISSN:1557-8852
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Recent successes in the development of new therapies for metastatic melanoma, such as mitogen-activated protein kinase pathway inhibitors, anticytotoxic T lymphocyte-associated antigen-4, and programmed cell death protein 1/programmed cell death ligand 1 (PD-L1) pathway-blocking antibodies, as well as combination strategies, all yielded promising results, changing the continually evolving landscape of therapeutic options for patients with melanoma. One promising new treatment modality is based on the use of immunomodulatory monoclonal antibodies that enhance the function of components of the antitumor immune response such as T cells or block immunologic checkpoints that restrain effective antitumor immunity. Program death-1 receptor and its ligand, PD-L1, is a major mechanism by which a tumor suppresses T cell-mediated antitumor immune responses. Studies in mice have shown that GK-1, an 18 amino acid peptide from Taenia crassiceps cisticerci, has the potential to be used as a primary or adjuvant component for the treatment of cancers by stimulating proinflammatory cytokines. The authors hypothesized that treatment with GK-1 in combination with anti-PD-L1 will increase survival in mice bearing melanoma tumors. C57BL/6 mice were injected with B16-F10-luc2 cells and separated into four groups: control, GK-1, anti-PD-L1, and GK-1/anti-PD-L1. The tumor sizes were measured and monitored using calipers and bioluminescence. The GK-1 peptide in combination with anti-PD-L1 showed significantly longer survival (34 days) compared with the other groups (23-27 days). This means an increase; survival increased 47.82% in the mice treated with GK-1+anti-PD-L1, 21.7% in mice treated with GK-1 alone, and 6.08% in those mice treated with anti-PD-L1 only. Blood samples were collected at days 0, 14, and at euthanization or end of the experiment and monitored for cytokines using mouse-specific V-PLEX Proinflammatory Panel. A decrease in TNF-α, IL-4, IL-5, IL-6, and IL-10 serum levels was observed in the GK-1/anti-PD-L1 combination group that may explain the beneficial effects of the combination treatment in prolonging the life of mice bearing melanoma. The data indicate that GK-1/anti-PD-L1 combined therapy affectively increases survival and warrants further clinical investigations.
[Mh] Termos MeSH primário: Anticorpos Monoclonais/uso terapêutico
Antineoplásicos/uso terapêutico
Antígeno B7-H1/antagonistas & inibidores
Melanoma/tratamento farmacológico
Peptídeos Cíclicos/uso terapêutico
[Mh] Termos MeSH secundário: Animais
Linhagem Celular Tumoral
Citocinas/metabolismo
Regulação Neoplásica da Expressão Gênica
Imunoterapia/métodos
Inflamação
Luminescência
Masculino
Melanoma Experimental
Camundongos
Camundongos Endogâmicos C57BL
Transplante de Neoplasias
Peptídeos/uso terapêutico
Modelos de Riscos Proporcionais
Taenia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Monoclonal); 0 (Antineoplastic Agents); 0 (B7-H1 Antigen); 0 (CD274 protein, human); 0 (Cytokines); 0 (Peptides); 0 (Peptides, Cyclic); 0 (cyclo(cysteinyl-glycyl-aspargyl-seryl-aspargyl-prolyl-lysyl-seryl-cysteine))
[Em] Mês de entrada:1704
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170317
[St] Status:MEDLINE
[do] DOI:10.1089/cbr.2016.2123



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