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[PMID]:29284011
[Au] Autor:Pajuelo MJ; Eguiluz M; Roncal E; Quiñones-García S; Clipman SJ; Calcina J; Gavidia CM; Sheen P; Garcia HH; Gilman RH; Gonzalez AE; Zimic M; Cysticercosis Working Group in Peru
[Ad] Endereço:Laboratorio de Bioinformática y Biología Molecular, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Peru.
[Ti] Título:Genetic variability of Taenia solium cysticerci recovered from experimentally infected pigs and from naturally infected pigs using microsatellite markers.
[So] Source:PLoS Negl Trop Dis;11(12):e0006087, 2017 12.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The adult Taenia solium, the pork tapeworm, usually lives as a single worm in the small intestine of humans, its only known definitive host. Mechanisms of genetic variation in T. solium are poorly understood. Using three microsatellite markers previously reported [1], this study explored the genetic variability of T. solium from cysts recovered from experimentally infected pigs. It then explored the genetic epidemiology and transmission in naturally infected pigs and adult tapeworms recovered from human carriers from an endemic rural community in Peru. In an initial study on experimental infection, two groups of three piglets were each infected with proglottids from one of two genetically different tapeworms for each of the microsatellites. After 7 weeks, pigs were slaughtered and necropsy performed. Thirty-six (92.3%) out of 39 cysts originated from one tapeworm, and 27 (100%) out of 27 cysts from the other had exactly the same genotype as the parental tapeworm. This suggests that the microsatellite markers may be a useful tool for studying the transmission of T. solium. In the second study, we analyzed the genetic variation of T. solium in cysts recovered from eight naturally infected pigs, and from adult tapeworms recovered from four human carriers; they showed genetic variability. Four pigs had cysts with only one genotype, and four pigs had cysts with two different genotypes, suggesting that multiple infections of genetically distinct parental tapeworms are possible. Six pigs harbored cysts with a genotype corresponding to one of the identified tapeworms from the human carriers. In the dendrogram, cysts appeared to cluster within the corresponding pigs as well as with the geographical origin, but this association was not statistically significant. We conclude that genotyping of microsatellite size polymorphisms is a potentially important tool to trace the spread of infection and pinpoint sources of infection as pigs spread cysts with a shared parental genotype.
[Mh] Termos MeSH primário: Cisticercose/veterinária
Repetições de Microssatélites/genética
Taenia solium/genética
Teníase/veterinária
[Mh] Termos MeSH secundário: Animais
Cisticercose/parasitologia
Cisticercose/transmissão
Cysticercus/genética
Cysticercus/isolamento & purificação
Cistos/parasitologia
Modelos Animais de Doenças
Feminino
Variação Genética/genética
Genótipo
Masculino
Peru
Sus scrofa
Suínos
Doenças dos Suínos/parasitologia
Taenia solium/isolamento & purificação
Teníase/parasitologia
Teníase/transmissão
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180130
[Lr] Data última revisão:
180130
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171229
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0006087


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[PMID]:28449318
[Au] Autor:Zammarchi L; Bonati M; Strohmeyer M; Albonico M; Requena-Méndez A; Bisoffi Z; Nicoletti A; García HH; Bartoloni A; COHEMI Project Study Group
[Ad] Endereço:Unità di Malattie Infettive, Università Degli Studi di Firenze, Florence, Italy.
[Ti] Título:Screening, diagnosis and management of human cysticercosis and Taenia solium taeniasis: technical recommendations by the COHEMI project study group.
[So] Source:Trop Med Int Health;22(7):881-894, 2017 07.
[Is] ISSN:1365-3156
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Neurocysticercosis, the central nervous system's localised form of cysticercosis, is considered to be the leading cause of epilepsy in the developing world. In Europe, the disease is mainly imported and affects both immigrants and travellers. However, autochthonous cases of cysticercosis in low-endemic countries could also originate from Taenia solium carriers (migrants or travellers) who acquired taeniasis overseas. Management of cysticercosis is a challenge for European healthcare providers as they are often hardly aware of this infection and have little familiarity in managing this disease. This study provides a summary of recommendations concerning screening, diagnosis and management of cysticercosis and T. solium taeniasis in Europe drawn up by nine experts in migrant health and imported diseases with experience in cysticercosis and T. solium taeniasis.
[Mh] Termos MeSH primário: Antiparasitários/uso terapêutico
Cisticercose/diagnóstico
Cisticercose/tratamento farmacológico
Taenia solium/isolamento & purificação
[Mh] Termos MeSH secundário: Animais
Europa (Continente)
Seres Humanos
América Latina
Migrantes
[Pt] Tipo de publicação:JOURNAL ARTICLE; PRACTICE GUIDELINE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antiparasitic Agents)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:180129
[Lr] Data última revisão:
180129
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170428
[St] Status:MEDLINE
[do] DOI:10.1111/tmi.12887


  3 / 842 MEDLINE  
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[PMID]:28467600
[Au] Autor:Arora N; Tripathi S; Kumar P; Mondal P; Mishra A; Prasad A
[Ad] Endereço:School of Basic Sciences, Indian Institute of Technology Mandi, Mandi, India.
[Ti] Título:Recent advancements and new perspectives in animal models for Neurocysticercosis immunopathogenesis.
[So] Source:Parasite Immunol;39(7), 2017 Jul.
[Is] ISSN:1365-3024
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Neurocysticercosis (NCC), one of the most common parasitic diseases of the central nervous system, is caused by Taenia solium. This parasite involves two hosts, intermediate hosts (pig and human) and a definitive host (human) and has various stages in its complex life cycle (eggs, oncosphere, cysticerci and adult tapeworm). Hence, developing an animal model for T. solium that mimics its natural course of infection is quite challenging. We have reviewed here the animal models frequently used to study immunopathogenesis of cysticercosis and also discussed their usefulness for NCC studies. We found that researchers have used mice, rats, guinea pigs, dogs, cats and pigs as models for this disease with varying degrees of success. Mice and rats models have been utilized extensively for immunopathogenesis studies due to their relative ease of handling and abundance of commercially available reagents to study these small animal models. These models have provided some very exciting results for in-depth understanding of the disease. Of late, the experimentally/naturally infected swine model is turning out to be the best animal model as the disease progression closely resembles human infection in pigs. However, handling large experimental animals has its own challenges and limitations.
[Mh] Termos MeSH primário: Modelos Animais de Doenças
Neurocisticercose/imunologia
Taenia solium/imunologia
Taenia/imunologia
Teníase/imunologia
[Mh] Termos MeSH secundário: Animais
Chinchila
Cricetinae
Seres Humanos
Estágios do Ciclo de Vida
Macaca mulatta
Neurocisticercose/parasitologia
Ratos
Suínos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171228
[Lr] Data última revisão:
171228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE
[do] DOI:10.1111/pim.12439


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[PMID]:29190292
[Au] Autor:Mahanty S; Orrego MA; Cangalaya C; Adrianzen MP; Arroyo G; Calcina J; Gonzalez AE; García HH; Guerra-Giraldez C; Nash TE; Cysticercosis Working Group in Peru
[Ad] Endereço:Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.
[Ti] Título:TNF-α blockade suppresses pericystic inflammation following anthelmintic treatment in porcine neurocysticercosis.
[So] Source:PLoS Negl Trop Dis;11(11):e0006059, 2017 Nov.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Neurocysticercosis (NCC) is an infection of the brain with the larval cyst of the tapeworm, Taenia solium. Cysticidal treatment induces parasite killing resulting in a post inflammatory response and seizures, which generally requires corticosteroid treatment to control inflammation. The nature of this response and how to best control it is unclear. We investigated the anti-inflammatory effects of pretreatment with etanercept (ETN), an anti-tumor necrosis factor agent, or dexamethasone (DEX), a high potency corticosteroid, on the post treatment inflammatory response in naturally infected pigs with neurocysticercosis after a single dose of the cysticidal drug praziquantel (PZQ). METHODOLOGY/PRINCIPAL FINDINGS: We followed the methods from a previously developed treatment model of NCC in naturally infected swine. The four study groups of infected pigs included 3 groups treated with PZQ on day 0: PZQ-treated alone (100 mg/kg PO; n = 9), pretreated with dexamethasone (DEX, 0.2 mg/kg IM administered on days -1, +1 and +3; n = 6), and pretreated with etanercept (ETN, 25 mg IM per animal on days -7 and 0; n = 6). The fourth group remained untreated (n = 3). As measured by quantitative RT-PCR, ETN pretreatment depressed transcription of a wide range of proinflammatory, regulatory and matrix protease encoding genes at 120 hr post PZQ treatment in capsules of cysts that demonstrated extravasated Evans Blue (EB) (a measure of blood brain barrier dysfunction) compared to animals not receiving ETN. Transcription was significantly depressed for the proinflammatory genes tumor necrosis factor (TNF)-α, and interferon (IFN)-γ; the inflammation regulating genes cytotoxic T-lymphocyte-associated protein (CTLA)4, interleukin (IL)-13 and transforming growth factor (TGF)-ß; the tissue remodeling genes matrix metalloprotease (MMP)1 and 9, tissue inhibitors of metalloproteases (TIMP)1 and 2, and the genes regulating endothelial function vascular endothelial growth factor (VEGF)1, angiopoietin (Ang)1, Ang 2, and platelet endothelial cell adhesion molecule (PECAM)-1. In contrast, transcription was only modestly decreased in the DEX pretreated pigs compared to PZQ alone, and only for TNF-α, IL-6, IFN-γ, TGF-ß and Ang1. IL-10 was not affected by either ETN or DEX pretreatments. The degree of inflammation, assessed by semi-quantitative inflammatory scores, was modestly decreased in both ETN and DEX pretreated animals compared to PZQ treated pigs whereas cyst damage scores were moderately decreased only in cysts from DEX pretreated pigs. However, the proportion of cysts with EB extravasation was not significantly changed in ETN and DEX pretreated groups. CONCLUSIONS/SIGNIFICANCE: Overall, TNF-α blockade using ETN treatment modulated expression of a large variety of genes that play a role in induction and control of inflammation and structural changes. In contrast the number of inflammatory cells was only moderately decreased suggesting weaker effects on cell migration into the inflammatory capsules surrounding cysts than on release of modulatory molecules. Taken together, these data suggest that TNF-α blockade may provide a viable strategy to manage post-treatment pericystic inflammation that follows antiparasitic therapy for neurocysticercosis.
[Mh] Termos MeSH primário: Etanercepte/administração & dosagem
Imunossupressores/administração & dosagem
Inflamação/prevenção & controle
Neurocisticercose/veterinária
Doenças dos Suínos/tratamento farmacológico
Fator de Necrose Tumoral alfa/antagonistas & inibidores
[Mh] Termos MeSH secundário: Animais
Anticestoides/uso terapêutico
Antiparasitários/efeitos adversos
Antiparasitários/uso terapêutico
Barreira Hematoencefálica/efeitos dos fármacos
Encéfalo/parasitologia
Citocinas/genética
Citocinas/imunologia
Dexametasona/administração & dosagem
Dexametasona/efeitos adversos
Etanercepte/efeitos adversos
Imunossupressores/efeitos adversos
Interferon gama/genética
Interferon gama/imunologia
Neurocisticercose/complicações
Neurocisticercose/tratamento farmacológico
Neurocisticercose/imunologia
Praziquantel/administração & dosagem
Praziquantel/efeitos adversos
Praziquantel/uso terapêutico
Suínos
Doenças dos Suínos/imunologia
Taenia solium/efeitos dos fármacos
Fator de Necrose Tumoral alfa/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anticestodal Agents); 0 (Antiparasitic Agents); 0 (Cytokines); 0 (Immunosuppressive Agents); 0 (Tumor Necrosis Factor-alpha); 6490C9U457 (Praziquantel); 7S5I7G3JQL (Dexamethasone); 82115-62-6 (Interferon-gamma); OP401G7OJC (Etanercept)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171219
[Lr] Data última revisão:
171219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171201
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0006059


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[PMID]:29095820
[Au] Autor:Marzano V; Mancinelli L; Bracaglia G; Del Chierico F; Vernocchi P; Di Girolamo F; Garrone S; Tchidjou Kuekou H; D'Argenio P; Dallapiccola B; Urbani A; Putignani L
[Ad] Endereço:Human Microbiome Unit, Bambino Gesù Children's Hospital IRCCS, Rome, Italy.
[Ti] Título:"Omic" investigations of protozoa and worms for a deeper understanding of the human gut "parasitome".
[So] Source:PLoS Negl Trop Dis;11(11):e0005916, 2017 Nov.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The human gut has been continuously exposed to a broad spectrum of intestinal organisms, including viruses, bacteria, fungi, and parasites (protozoa and worms), over millions of years of coevolution, and plays a central role in human health. The modern lifestyles of Western countries, such as the adoption of highly hygienic habits, the extensive use of antimicrobial drugs, and increasing globalisation, have dramatically altered the composition of the gut milieu, especially in terms of its eukaryotic "citizens." In the past few decades, numerous studies have highlighted the composition and role of human intestinal bacteria in physiological and pathological conditions, while few investigations exist on gut parasites and particularly on their coexistence and interaction with the intestinal microbiota. Studies of the gut "parasitome" through "omic" technologies, such as (meta)genomics, transcriptomics, proteomics, and metabolomics, are herein reviewed to better understand their role in the relationships between intestinal parasites, host, and resident prokaryotes, whether pathogens or commensals. Systems biology-based profiles of the gut "parasitome" under physiological and severe disease conditions can indeed contribute to the control of infectious diseases and offer a new perspective of omics-assisted tropical medicine.
[Mh] Termos MeSH primário: Trato Gastrointestinal/parasitologia
Genômica
Interações Hospedeiro-Parasita
Metabolômica
Parasitos/fisiologia
Proteômica
[Mh] Termos MeSH secundário: Animais
Entamoeba histolytica/genética
Entamoeba histolytica/metabolismo
Microbioma Gastrointestinal
Giardia/genética
Giardia/metabolismo
Helmintos/genética
Helmintos/fisiologia
Seres Humanos
Camundongos
Taenia solium/genética
Taenia solium/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171119
[Lr] Data última revisão:
171119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171103
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0005916


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[PMID]:29036211
[Au] Autor:Mendlovic F; Cruz-Rivera M; Diaz-Gandarilla JA; Flores-Torres MA; Avila G; Perfiliev M; Salazar AM; Arriaga-Pizano L; Ostrosky-Wegman P; Flisser A
[Ad] Endereço:Departamento de Microbiologia y Parasitologia, Facultad de Medicina, Universidad Nacional Autonoma de Mexico, Ciudad de Mexico, Mexico.
[Ti] Título:Orally administered Taenia solium Calreticulin prevents experimental intestinal inflammation and is associated with a type 2 immune response.
[So] Source:PLoS One;12(10):e0186510, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Intestinal helminth antigens are inducers of type 2 responses and can elicit regulatory immune responses, resulting in dampened inflammation. Several platyhelminth proteins with anti-inflammatory activity have been reported. We have identified, cloned and expressed the Taenia solium calreticulin (rTsCRT) and shown that it predominantly induces a type 2 response characterized by IgG1, IL-4 and IL-5 production in mice. Here, we report the rTsCRT anti-inflammatory activity in a well-known experimental colitis murine model. Mice were orally immunized with purified rTsCRT and colitis was induced with trinitrobenzene sulfonic acid (TNBS). Clinical signs of disease, macroscopic and microscopic tissue inflammation, cytokine production and micronuclei formation, as a marker of genotoxicity, were measured in order to assess the effect of rTsCRT immunization on experimentally induced colitis. rTsCRT administration prior to TNBS instillation significantly reduced the inflammatory parameters, including the acute phase cytokines TNF-α, IL-1ß and IL-6. Dampened inflammation was associated with increased local expression of IL-13 and systemic IL-10 and TGF-ß production. Genotoxic damage produced by the inflammatory response was also precluded. Our results show that oral treatment with rTsCRT prevents excessive TNBS-induced inflammation in mice and suggest that rTsCRT has immunomodulatory properties associated with the expression of type 2 and regulatory cytokines commonly observed in other helminths.
[Mh] Termos MeSH primário: Calreticulina/administração & dosagem
Calreticulina/farmacologia
Colite/imunologia
Colite/prevenção & controle
Intestinos/efeitos dos fármacos
Intestinos/imunologia
Taenia solium/química
[Mh] Termos MeSH secundário: Administração Oral
Animais
Anti-Inflamatórios/administração & dosagem
Anti-Inflamatórios/farmacologia
Antígenos de Helmintos/imunologia
Colite/metabolismo
Citocinas/metabolismo
Dano ao DNA
Modelos Animais de Doenças
Imunomodulação/efeitos dos fármacos
Intestinos/metabolismo
Camundongos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Antigens, Helminth); 0 (Calreticulin); 0 (Cytokines)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171106
[Lr] Data última revisão:
171106
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171017
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0186510


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[PMID]:28945737
[Au] Autor:Navarrete-Perea J; Isasa M; Paulo JA; Corral-Corral R; Flores-Bautista J; Hernández-Téllez B; Bobes RJ; Fragoso G; Sciutto E; Soberón X; Gygi SP; Laclette JP
[Ad] Endereço:Dept. of Immunology, Institute for Biomedical Research, Universidad Nacional Autónoma de México, Ciudad de México, México.
[Ti] Título:Quantitative multiplexed proteomics of Taenia solium cysts obtained from the skeletal muscle and central nervous system of pigs.
[So] Source:PLoS Negl Trop Dis;11(9):e0005962, 2017 Sep.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In human and porcine cysticercosis caused by the tapeworm Taenia solium, the larval stage (cysts) can infest several tissues including the central nervous system (CNS) and the skeletal muscles (SM). The cyst's proteomics changes associated with the tissue localization in the host tissues have been poorly studied. Quantitative multiplexed proteomics has the power to evaluate global proteome changes in response to different conditions. Here, using a TMT-multiplexed strategy we identified and quantified over 4,200 proteins in cysts obtained from the SM and CNS of pigs, of which 891 were host proteins. To our knowledge, this is the most extensive intermixing of host and parasite proteins reported for tapeworm infections.Several antigens in cysticercosis, i.e., GP50, paramyosin and a calcium-binding protein were enriched in skeletal muscle cysts. Our results suggested the occurrence of tissue-enriched antigen that could be useful in the improvement of the immunodiagnosis for cysticercosis. Using several algorithms for epitope detection, we selected 42 highly antigenic proteins enriched for each tissue localization of the cysts. Taking into account the fold changes and the antigen/epitope contents, we selected 10 proteins and produced synthetic peptides from the best epitopes. Nine peptides were recognized by serum antibodies of cysticercotic pigs, suggesting that those peptides are antigens. Mixtures of peptides derived from SM and CNS cysts yielded better results than mixtures of peptides derived from a single tissue location, however the identification of the 'optimal' tissue-enriched antigens remains to be discovered. Through machine learning technologies, we determined that a reliable immunodiagnostic test for porcine cysticercosis required at least five different antigenic determinants.
[Mh] Termos MeSH primário: Sistema Nervoso Central/parasitologia
Proteínas de Helminto/análise
Músculo Esquelético/parasitologia
Proteoma/análise
Doenças dos Suínos/parasitologia
Taenia solium/química
Teníase/veterinária
[Mh] Termos MeSH secundário: Animais
Proteômica
Suínos
Taenia solium/isolamento & purificação
Teníase/parasitologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Helminth Proteins); 0 (Proteome)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170926
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0005962


  8 / 842 MEDLINE  
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[PMID]:28892472
[Au] Autor:Donadeu M; Fahrion AS; Olliaro PL; Abela-Ridder B
[Ad] Endereço:The University of Melbourne, Faculty of Veterinary and Agricultural Sciences, Veterinary Clinical Centre, Werribee, Victoria, Australia.
[Ti] Título:Target product profiles for the diagnosis of Taenia solium taeniasis, neurocysticercosis and porcine cysticercosis.
[So] Source:PLoS Negl Trop Dis;11(9):e0005875, 2017 Sep.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Target Product Profiles (TPPs) are process tools providing product requirements to guide researchers, developers and manufacturers in their efforts to develop effective and useful products such as biologicals, drugs or diagnostics. During a WHO Stakeholders Meeting on Taenia solium diagnostics, several TPPs were initiated to address diagnostic needs for different stages in the parasite's transmission (taeniasis, human and porcine cysticercosis). Following the meeting, draft TPPs were completed and distributed for consultation to 100 people/organizations, including experts in parasitology, human and pig cysticercosis, diagnostic researchers and manufacturers, international organizations working with neglected or zoonotic diseases, Ministries of Health and Ministries of Livestock in some of the endemic countries, WHO regional offices and other interested parties. There were 53 respondents. All comments and feedback received were considered and discussions were held with different experts according to their area of expertise. The comments were consolidated and final TPPs are presented here. They are considered to be live documents which are likely to undergo review and updating in the future when new knowledge and technologies become available.
[Mh] Termos MeSH primário: Cisticercose/veterinária
Neurocisticercose/diagnóstico
Doenças dos Suínos/diagnóstico
Taenia solium/isolamento & purificação
Teníase/diagnóstico
[Mh] Termos MeSH secundário: Animais
Cisticercose/diagnóstico
Cisticercose/epidemiologia
Cisticercose/parasitologia
Seres Humanos
Neurocisticercose/epidemiologia
Neurocisticercose/parasitologia
Suínos
Doenças dos Suínos/epidemiologia
Doenças dos Suínos/parasitologia
Teníase/epidemiologia
Teníase/parasitologia
Organização Mundial da Saúde
Zoonoses
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170912
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0005875


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[PMID]:28850668
[Au] Autor:Del Brutto OH; Arroyo G; Del Brutto VJ; Zambrano M; García HH
[Ad] Endereço:School of Medicine, Universidad Espiritu Santo-Ecuador, Guayaquil, Ecuador.
[Ti] Título:On the relationship between calcified neurocysticercosis and epilepsy in an endemic village: A large-scale, computed tomography-based population study in rural Ecuador.
[So] Source:Epilepsia;58(11):1955-1961, 2017 Nov.
[Is] ISSN:1528-1167
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Using a large-scale population-based study, we aimed to assess prevalence and patterns of presentation of neurocysticercosis (NCC) and its relationship with epilepsy in community-dwellers aged ≥20 years living in Atahualpa (rural Ecuador). METHODS: In a three-phase epidemiological study, individuals with suspected seizures were identified during a door-to-door survey and an interview (phase I). Then, neurologists evaluated suspected cases and randomly selected negative persons to estimate epilepsy prevalence (phase II). In phase III, all participants were offered noncontrast computed tomography (CT) for identifying NCC cases. The independent association between NCC (exposure) and epilepsy (outcome) was assessed by the use of multivariate logistic regression models adjusted for age, sex, level of education, and alcohol intake. CT findings were subsequently compared to archived brain magnetic resonance imaging in a sizable subgroup of participants. RESULTS: Of 1,604 villagers aged ≥20 years, 1,462 (91%) were enrolled. Forty-one persons with epilepsy (PWE) were identified, for a crude prevalence of epilepsy of 28 per 1,000 population (95% confidence interval [CI] = 20.7-38.2). A head CT was performed in 1,228 (84%) of 1,462 participants, including 39 of 41 PWE. CT showed lesions consistent with calcified parenchymal brain cysticerci in 118 (9.6%) cases (95% CI = 8.1-11.4%). No patient had other forms of NCC. Nine of 39 PWE, as opposed to 109 of 1,189 participants without epilepsy, had NCC (23.1% vs. 9.2%, p = 0.004). This difference persisted in the adjusted logistic regression model (odds ratio = 3.04, 95% CI = 1.35-6.81, p = 0.007). SIGNIFICANCE: This large CT-based study demonstrates that PWE had three times the odds of having NCC than those without epilepsy, providing robust epidemiological evidence favoring the relationship between NCC and epilepsy.
[Mh] Termos MeSH primário: Calcinose/diagnóstico por imagem
Epilepsia/diagnóstico por imagem
Neurocisticercose/diagnóstico por imagem
Vigilância da População
População Rural
Tomografia Computadorizada por Raios X
[Mh] Termos MeSH secundário: Adulto
Animais
Calcinose/epidemiologia
Estudos Transversais
Equador/epidemiologia
Epilepsia/epidemiologia
Feminino
Seres Humanos
Masculino
Meia-Idade
Neurocisticercose/epidemiologia
Vigilância da População/métodos
Distribuição Aleatória
Suínos
Taenia solium/isolamento & purificação
Teníase/diagnóstico por imagem
Teníase/epidemiologia
Tomografia Computadorizada por Raios X/métodos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171109
[Lr] Data última revisão:
171109
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170830
[St] Status:MEDLINE
[do] DOI:10.1111/epi.13892


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[PMID]:28821422
[Au] Autor:Singh SK; Prasad KN; Singh AK; Gupta KK; Singh A; Tripathi M; Gupta RK
[Ad] Endereço:Department of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, U.P 226014, India.
[Ti] Título:Adhesion molecules, chemokines and matrix metallo-proteinases response after albendazole and albendazole plus steroid therapy in swine neurocysticercosis.
[So] Source:Exp Parasitol;182:1-8, 2017 Nov.
[Is] ISSN:1090-2449
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The treatment of neurocysticercosis (NCC) varies with location, number and stage of the Taenia solium cysticerci (cysts). Albendazole (ABZ) effectively kills cysticerci, and subsequently induces neuro-inflammation facilitated by leukocyte infiltration. We hypothesize that immune response varies around drug responder (degenerating/dying) and non-responder (viable) cysts after ABZ and ABZ plus steroid (ABZS) therapy, which may determine the disease pathogenesis. Twenty cysticercotic swine were treated with ABZ (n = 10; group1) and ABZS (n = 10; group2). Expression of adhesion molecules, chemokines and matrix metallo-proteinases (MMPs) was measured by qRT-PCR (quantitative reverse transcriptase-polymerase chain reaction) and ELISA. Gelatin gel zymography was performed to detect the activity of MMP-2 and -9. In group1, ABZ therapy induced higher expressions of ICAM-1 (intercellular adhesion molecule-1), VCAM-1 (vascular cell adhesion molecule-1), E-selectin, MCP-1 (monocyte chemotactic protein-1), Eotaxin-1, MIP-1α (macrophage inflammatory protein-1α), RANTES (regulated on activation, normal T cell expressed and secreted), MMP-2 and MMP-9 around ABZ responder (AR) cysts. Three pigs with cyst burdens ≥10 died following ABZ therapy. However, in group2, moderate expressions of ICAM-1, VCAM-1, E-selectin, RANTES and MMP-9 were associated with ABZS responder (ASR), whereas low expressions of these molecules were associated with ABZS non-responder (ASNR) cysts. In conclusion, ABZ alone therapy is not safe since it causes death of pigs due to higher inflammatory immune response around dying cysts. However, combination therapy is an effective treatment regimen even with the high cyst burden.
[Mh] Termos MeSH primário: Albendazol/uso terapêutico
Antiprotozoários/uso terapêutico
Glucocorticoides/uso terapêutico
Neurocisticercose/veterinária
Prednisolona/uso terapêutico
Doenças dos Suínos/tratamento farmacológico
[Mh] Termos MeSH secundário: Animais
Encéfalo/diagnóstico por imagem
Encéfalo/parasitologia
Encéfalo/patologia
Moléculas de Adesão Celular/metabolismo
Quimiocinas/metabolismo
Quimioterapia Combinada/veterinária
Metaloproteinases da Matriz/metabolismo
Neurocisticercose/tratamento farmacológico
Neurocisticercose/metabolismo
Suínos
Doenças dos Suínos/metabolismo
Taenia solium
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antiprotozoal Agents); 0 (Cell Adhesion Molecules); 0 (Chemokines); 0 (Glucocorticoids); 9PHQ9Y1OLM (Prednisolone); EC 3.4.24.- (Matrix Metalloproteinases); F4216019LN (Albendazole)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170820
[St] Status:MEDLINE



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