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[PMID]:29329293
[Au] Autor:Ezeamama AE; Bustinduy AL; Nkwata AK; Martinez L; Pabalan N; Boivin MJ; King CH
[Ad] Endereço:Department of Psychiatry, College of Osteopathic Medicine, Michigan State University, East Lansing, Michigan, United States of America.
[Ti] Título:Cognitive deficits and educational loss in children with schistosome infection-A systematic review and meta-analysis.
[So] Source:PLoS Negl Trop Dis;12(1):e0005524, 2018 01.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: By means of meta-analysis of information from all relevant epidemiologic studies, we examined the hypothesis that Schistosoma infection in school-aged children (SAC) is associated with educational loss and cognitive deficits. METHODOLOGY/PRINCIPAL FINDINGS: This review was prospectively registered in the PROSPERO database (CRD42016040052). Medline, Biosis, and Web of Science were searched for studies published before August 2016 that evaluated associations between Schistosoma infection and cognitive or educational outcomes. Cognitive function was defined in four domains-learning, memory, reaction time, and innate intelligence. Educational outcome measures were defined as attendance and scholastic achievement. Risk of bias (ROB) was evaluated using the Newcastle-Ottawa quality assessment scale. Standardized mean differences (SMD) and 95% confidence intervals (CI) were calculated to compare cognitive and educational measures for Schistosoma infected /not dewormed vs. uninfected/dewormed children. Sensitivity analyses by study design, ROB, and sequential exclusion of individual studies were implemented. Thirty studies from 14 countries, including 38,992 SAC between 5-19 years old, were identified. Compared to uninfected children and children dewormed with praziquantel, the presence of Schistosoma infection and/or non-dewormed status was associated with deficits in school attendance (SMD = -0.36, 95%CI: -0.60, -0.12), scholastic achievement (SMD = -0.58, 95%CI: -0.96, -0.20), learning (SMD = -0.39, 95%CI: -0.70, -0.09) and memory (SMD = -0.28, 95%CI: -0.52, -0.04) tests. By contrast, Schistosoma-infected/non-dewormed and uninfected/dewormed children were similar with respect to performance in tests of reaction time (SMD = -0.06, 95%CI: -0.42, 0.30) and intelligence (SMD = -0.25, 95%CI: -0.57, 0.06). Schistosoma infection-associated deficits in educational measures were robust among observational studies, but not among interventional studies. The significance of infection-associated deficits in scholastic achievement was sensitive to ROB. Schistosoma infection-related deficits in learning and memory tests were invariant by ROB and study design. CONCLUSION/SIGNIFICANCE: Schistosoma infection/non-treatment was significantly associated with educational, learning, and memory deficits in SAC. Early treatment of children in Schistosoma-endemic regions could potentially mitigate these deficits. TRIAL REGISTRATION: ClinicalTrials.gov CRD42016040052.
[Mh] Termos MeSH primário: Disfunção Cognitiva/parasitologia
Transtornos de Aprendizagem/parasitologia
Transtornos da Memória/parasitologia
Esquistossomose/complicações
[Mh] Termos MeSH secundário: Adolescente
Animais
Anti-Helmínticos/uso terapêutico
Criança
Pré-Escolar
Cognição/fisiologia
Seres Humanos
Inteligência/fisiologia
Memória/fisiologia
Testes de Memória e Aprendizagem
Praziquantel/uso terapêutico
Tempo de Reação/fisiologia
Schistosoma/patogenicidade
Esquistossomose/tratamento farmacológico
Esquistossomose/psicologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Nm] Nome de substância:
0 (Anthelmintics); 6490C9U457 (Praziquantel)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180210
[Lr] Data última revisão:
180210
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180113
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0005524


  2 / 2673 MEDLINE  
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[PMID]:29329288
[Au] Autor:Pabalan N; Singian E; Tabangay L; Jarjanazi H; Boivin MJ; Ezeamama AE
[Ad] Endereço:Center for Research and Development, Angeles University Foundation, Angeles City, Philippines.
[Ti] Título:Soil-transmitted helminth infection, loss of education and cognitive impairment in school-aged children: A systematic review and meta-analysis.
[So] Source:PLoS Negl Trop Dis;12(1):e0005523, 2018 01.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Evidence of an adverse influence of soil transmitted helminth (STH) infections on cognitive function and educational loss is equivocal. Prior meta-analyses have focused on randomized controlled trials only and have not sufficiently explored the potential for disparate influence of STH infection by cognitive domain. We re-examine the hypothesis that STH infection is associated with cognitive deficit and educational loss using data from all primary epidemiologic studies published between 1992 and 2016. METHODS: Medline, Biosis and Web of Science were searched for original studies published in the English language. Cognitive function was defined in four domains (learning, memory, reaction time and innate intelligence) and educational loss in two domains (attendance and scholastic achievement). Pooled effect across studies were calculated as standardized mean differences (SMD) to compare cognitive and educational measures for STH infected/non-dewormed children versus STH uninfected /dewormed children using Review Manager 5.3. Sub-group analyses were implemented by study design, risk of bias (ROB) and co-prevalence of Schistosoma species infection. Influential studies were excluded in sensitivity analysis to examine stability of pooled estimates. FINDINGS: We included 36 studies of 12,920 children. STH infected/non-dewormed children had small to moderate deficits in three domains-learning, memory and intelligence (SMD: -0.44 to -0.27, P<0.01-0.03) compared to STH-uninfected/dewormed children. There were no differences by infection/treatment status for reaction time, school attendance and scholastic achievement (SMD: -0.26 to -0.16, P = 0.06-0.19). Heterogeneity of the pooled effects in all six domains was high (P<0.01; I2 = 66-99%). Application of outlier treatment reduced heterogeneity in learning domain (P = 0.12; I2 = 33%) and strengthened STH-related associations in all domains but intelligence (SMD: -0.20, P = 0.09). Results varied by study design and ROB. Among experimental intervention studies, there was no association between STH treatment and educational loss/performance in tests of memory, reaction time and innate intelligence (SMD: -0.27 to 0.17, P = 0.18-0.69). Infection-related deficits in learning persisted within design/ROB levels (SMD: -0.37 to -52, P<0.01) except for pre-vs post intervention design (n = 3 studies, SMD = -0.43, P = 0.47). Deficits in memory, reaction time and innate intelligence persisted within observational studies (SMD: -0.23 to -0.38, all P<0.01) and high ROB strata (SMD:-0.37 to -0.83, P = 0.07 to <0.01). Further, in Schistosoma infection co-prevalent settings, associations were generally stronger and statistically robust for STH-related deficits in learning, memory and reaction time tests(SMD:-0.36 to -0.55, P = 0.003-0.02). STH-related deficits in school attendance and scholastic achievement was noted in low (SMD:-0.57, P = 0.05) and high ROB strata respectively. INTERPRETATION: We provide evidence of superior performance in five of six educational and cognitive domains assessed for STH uninfected/dewormed versus STH infected/not-dewormed school-aged children from helminth endemic regions. Cautious interpretation is warranted due to high ROB in some of the primary literature and high between study variability in most domains. Notwithstanding, this synthesis provides empirical support for a cognitive and educational benefit of deworming. The benefit of deworming will be enhanced by strategically employing, integrated interventions. Thus, multi-pronged inter-sectoral strategies that holistically address the environmental and structural roots of child cognitive impairment and educational loss in the developing world may be needed to fully realize the benefit of mass deworming programs.
[Mh] Termos MeSH primário: Disfunção Cognitiva/parasitologia
Testes de Memória e Aprendizagem
Esquistossomose/patologia
Esquistossomose/transmissão
Solo/parasitologia
[Mh] Termos MeSH secundário: Adolescente
Albendazol/uso terapêutico
Animais
Anti-Helmínticos/uso terapêutico
Criança
Pré-Escolar
Cognição/fisiologia
Avaliação Educacional
Função Executiva/fisiologia
Seres Humanos
Mebendazol/uso terapêutico
Schistosoma/isolamento & purificação
Esquistossomose/tratamento farmacológico
Esquistossomose/parasitologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Nm] Nome de substância:
0 (Anthelmintics); 0 (Soil); 81G6I5V05I (Mebendazole); F4216019LN (Albendazole)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180210
[Lr] Data última revisão:
180210
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180113
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0005523


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[PMID]:29253882
[Au] Autor:Beechler BR; Jolles AE; Budischak SA; Corstjens PLAM; Ezenwa VO; Smith M; Spaan RS; van Dam GJ; Steinauer ML
[Ad] Endereço:College of Veterinary Medicine, Oregon State University, Corvallis, OR, United States of America.
[Ti] Título:Host immunity, nutrition and coinfection alter longitudinal infection patterns of schistosomes in a free ranging African buffalo population.
[So] Source:PLoS Negl Trop Dis;11(12):e0006122, 2017 12.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Schistosomes are trematode parasites of global importance, causing infections in millions of people, livestock, and wildlife. Most studies on schistosomiasis, involve human subjects; as such, there is a paucity of longitudinal studies investigating parasite dynamics in the absence of intervention. As a consequence, despite decades of research on schistosomiasis, our understanding of its ecology in natural host populations is centered around how environmental exposure and acquired immunity influence acquisition of parasites, while very little is known about the influence of host physiology, coinfection and clearance in the absence of drug treatment. We used a 4-year study in free-ranging African buffalo to investigate natural schistosome dynamics. We asked (i) what are the spatial and temporal patterns of schistosome infections; (ii) how do parasite burdens vary over time within individual hosts; and (iii) what host factors (immunological, physiological, co-infection) and environmental factors (season, location) explain patterns of schistosome acquisition and loss in buffalo? Schistosome infections were common among buffalo. Microgeographic structure explained some variation in parasite burdens among hosts, indicating transmission hotspots. Overall, parasite burdens ratcheted up over time; however, gains in schistosome abundance in the dry season were partially offset by losses in the wet season, with some hosts demonstrating complete clearance of infection. Variation among buffalo in schistosome loss was associated with immunologic and nutritional factors, as well as co-infection by the gastrointestinal helminth Cooperia fuelleborni. Our results demonstrate that schistosome infections are surprisingly dynamic in a free-living mammalian host population, and point to a role for host factors in driving variation in parasite clearance, but not parasite acquisition which is driven by seasonal changes and spatial habitat utilization. Our study illustrates the power of longitudinal studies for discovering mechanisms underlying parasite dynamics in individual animals and populations.
[Mh] Termos MeSH primário: Búfalos/parasitologia
Interações Hospedeiro-Parasita/imunologia
Schistosoma/imunologia
Esquistossomose/transmissão
Esquistossomose/veterinária
Tricostrongiloidíase/veterinária
[Mh] Termos MeSH secundário: Animais
Búfalos/imunologia
Coinfecção/parasitologia
Feminino
Estudos Longitudinais
Schistosoma/crescimento & desenvolvimento
Esquistossomose/parasitologia
Esquistossomose/patologia
Estações do Ano
Trichostrongyloidea/crescimento & desenvolvimento
Trichostrongyloidea/imunologia
Tricostrongiloidíase/parasitologia
Tricostrongiloidíase/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180210
[Lr] Data última revisão:
180210
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171219
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0006122


  4 / 2673 MEDLINE  
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[PMID]:29235368
[Au] Autor:Lago EM; Xavier RP; Teixeira TR; Silva LM; da Silva Filho AA; de Moraes J
[Ad] Endereço:Núcleo de Pesquisa em Doenças Negligenciadas, Universidade Universus Veritas (UNIVERITAS UNG), Praça Tereza Cristina, 229, Centro, Guarulhos 07023-070, SP, Brazil.
[Ti] Título:Antischistosomal agents: state of art and perspectives.
[So] Source:Future Med Chem;10(1):89-120, 2018 Jan.
[Is] ISSN:1756-8927
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Praziquantel has remained the drug of choice for schistosomiasis chemotherapy for almost 40 years. The pressing need to develop a new antischistosomal drug may necessitate exploring and filtering chemotherapeutic history to search for the most promising ones. In this context, this review attempts to summarize all progress made in schistosomiasis chemotherapy from the early 20th century (mid-1910s) to 2016. We gathered almost 100 compounds providing information on therapeutic action, specifically covering at least first in vivo studies in animal model and in vitro. Pharmacokinetic and toxicity profiles of antischistosomal agents were also described. Preclinical studies indicate a handful of promising future candidates.
[Mh] Termos MeSH primário: Anti-Helmínticos/farmacologia
Praziquantel/farmacologia
Schistosoma/efeitos dos fármacos
Esquistossomose/tratamento farmacológico
[Mh] Termos MeSH secundário: Animais
Seres Humanos
Testes de Sensibilidade Parasitária
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Anthelmintics); 6490C9U457 (Praziquantel)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171225
[Lr] Data última revisão:
171225
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171214
[St] Status:MEDLINE
[do] DOI:10.4155/fmc-2017-0112


  5 / 2673 MEDLINE  
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[PMID]:28735972
[Au] Autor:El Kouni MH
[Ad] Endereço:Department of Pharmacology and Toxicology, Center for AIDS Research, Comprehensive Cancer Center, General Clinical Research Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA. Electronic address: melkouni@uab.edu.
[Ti] Título:Pyrimidine metabolism in schistosomes: A comparison with other parasites and the search for potential chemotherapeutic targets.
[So] Source:Comp Biochem Physiol B Biochem Mol Biol;213:55-80, 2017 Nov.
[Is] ISSN:1879-1107
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Schistosomes are responsible for the parasitic disease schistosomiasis, an acute and chronic parasitic ailment that affects >240 million people in 70 countries worldwide. It is the second most devastating parasitic disease after malaria. At least 200,000 deaths per year are associated with the disease. In the absence of the availability of vaccines, chemotherapy is the main stay for combating schistosomiasis. The antischistosomal arsenal is currently limited to a single drug, Praziquantel, which is quite effective with a single-day treatment and virtually no host-toxicity. Recently, however, the question of reduced activity of Praziquantel has been raised. Therefore, the search for alternative antischistosomal drugs merits the study of new approaches of chemotherapy. The rational design of a drug is usually based on biochemical and physiological differences between pathogens and host. Pyrimidine metabolism is an excellent target for such studies. Schistosomes, unlike most of the host tissues, require a very active pyrimidine metabolism for the synthesis of DNA and RNA. This is essential for the production of the enormous numbers of eggs deposited daily by the parasite to which the granulomas response precipitates the pathogenesis of schistosomiasis. Furthermore, there are sufficient differences between corresponding enzymes of pyrimidine metabolism from the host and the parasite that can be exploited to design specific inhibitors or "subversive substrates" for the parasitic enzymes. Specificities of pyrimidine transport also diverge significantly between parasites and their mammalian host. This review deals with studies on pyrimidine metabolism in schistosomes and highlights the unique characteristic of this metabolism that could constitute excellent potential targets for the design of safe and effective antischistosomal drugs. In addition, pyrimidine metabolism in schistosomes is compared with that in other parasites where studies on pyrimidine metabolism have been more elaborate, in the hope of providing leads on how to identify likely chemotherapeutic targets which have not been looked at in schistosomes.
[Mh] Termos MeSH primário: Pirimidinas/biossíntese
Schistosoma/metabolismo
Esquistossomose/metabolismo
[Mh] Termos MeSH secundário: Animais
Praziquantel/uso terapêutico
Esquistossomose/tratamento farmacológico
Esquistossomicidas/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Pyrimidines); 0 (Schistosomicides); 6490C9U457 (Praziquantel); K8CXK5Q32L (pyrimidine)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170915
[Lr] Data última revisão:
170915
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170725
[St] Status:MEDLINE


  6 / 2673 MEDLINE  
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[PMID]:28416001
[Au] Autor:Hu Y; Xia C; Li S; Ward MP; Luo C; Gao F; Wang Q; Zhang S; Zhang Z
[Ad] Endereço:Department of Epidemiology, School of Public Health, Fudan University, Shanghai, 200032, China.
[Ti] Título:Assessing environmental factors associated with regional schistosomiasis prevalence in Anhui Province, Peoples' Republic of China using a geographical detector method.
[So] Source:Infect Dis Poverty;6(1):87, 2017 Apr 17.
[Is] ISSN:2049-9957
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Schistosomiasis is a water-borne disease caused by trematode worms belonging to genus Schistosoma, which is prevalent most of the developing world. Transmission of the disease is usually associated with multiple biological characteristics and social factors but also factors can play a role. Few studies have assessed the exact and interactive influence of each factor promoting schistosomiasis transmission. METHODS: We used a series of different detectors (i.e., specific detector, risk detector, ecological detector and interaction detector) to evaluate separate and interactive effects of the environmental factors on schistosomiasis prevalence. Specifically, (i) specific detector quantifies the impact of a risk factor on an observed spatial disease pattern, which were ranked statistically by a value of Power of Determinate (PD) calculation; (ii) risk detector detects high risk areas of a disease on the condition that the study area is stratified by a potential risk factor; (iii) ecological detector explores whether a risk factor is more significant than another in controlling the spatial pattern of a disease; (iv) interaction detector probes whether two risk factors when taken together weaken or enhance one another, or whether they are independent in developing a disease. Infection data of schistosomiasis based on conventional surveys were obtained at the county level from the health authorities in Anhui Province, China and used in combination with information from Chinese weather stations and internationally available environmental data. RESULTS: The specific detector identified various factors of potential importance as follows: Proximity to Yangtze River (0.322) > Land cover (0.285) > sunshine hours (0.256) > population density (0.109) > altitude (0.090) > the normalized different vegetation index (NDVI) (0.077) > land surface temperature at daytime (LST ) (0.007). The risk detector indicated that areas of schistosomiasis high risk were located within a buffer distance of 50 km from Yangtze River. The ecological detector disclosed that the factors investigated have significantly different effects. The interaction detector revealed that interaction between the factors enhanced their main effects in most cases. CONCLUSION: Proximity to Yangtze River had the strongest effect on schistosomiasis prevalence followed by land cover and sunshine hours, while the remaining factors had only weak influence. Interaction between factors played an even more important role in influencing schistosomiasis prevalence than each factor on its own. High risk regions influenced by strong interactions need to be targeted for disease control intervention.
[Mh] Termos MeSH primário: Meio Ambiente
Schistosoma/isolamento & purificação
Esquistossomose/epidemiologia
Topografia Médica
[Mh] Termos MeSH secundário: Animais
Estudos Transversais
Transmissão de Doença Infecciosa
Seres Humanos
Prevalência
Esquistossomose/transmissão
Taiwan/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170425
[Lr] Data última revisão:
170425
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170419
[St] Status:MEDLINE
[do] DOI:10.1186/s40249-017-0299-x


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[PMID]:28407789
[Au] Autor:Du X; McManus DP; Cai P; Hu W; You H
[Ad] Endereço:Molecular Parasitology Laboratory, Infectious Diseases Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
[Ti] Título:Identification and functional characterisation of a Schistosoma japonicum insulin-like peptide.
[So] Source:Parasit Vectors;10(1):181, 2017 Apr 14.
[Is] ISSN:1756-3305
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Previous studies have shown that insulin receptors in schistosomes, triggered by host insulin, play an important role in parasite growth, development and fecundity by regulating glucose metabolism. However, limited information is available on the recently identified endogenous insulin-like peptide (ILP) in blood flukes. RESULTS: We isolated ILPs from Schistosoma japonicum (SjILP) and S. recognised (SmILP) and present results of their molecular and structural analysis. SjILP shares 63% amino acid identity with SmILP, but only 18% identity with human insulin. There is high cross immunological reactivity between the S. japonicum and S. mansoni ILPs as observed in western blots using an anti-SjILP polyclonal antibody. ADP binding/hydrolysis ability was observed in both SjILP and SmILP, but not in human insulin, suggesting a parasite-specific role for ILP compared with host insulin. Protein binding assays using the Octet-RED system showed SjILP binds S. japonicum IRs (SjIR1 and SjIR2) strongly. An anti-phospho antibody against extracellular signal-regulated kinase (Erk) recognised a 44-kDa target band in an extract of adult worms after stimulation by rSjILP in vitro, suggesting an important role for SjILP in activating SjIRs and in regulating downstream signal transduction. Immunolocalisation showed SjILP is located on the tegument and the underlying musculature, similar to that observed for SjIR1, but it is also present throughout the parenchyma of males and in the vitelline cells of females, the same locations as SjIR2 described in an earlier published study of ours. The same localisation of SjILP and the SjIRs is suggestive of an interaction between the insulin-like peptide and the IRs. In addition to binding host insulin, schistosomes also can express their own endogenous ILPs, which can activate the parasite insulin signal pathway, thereby playing a critical role in worm growth, development and fertility. CONCLUSIONS: These findings shed new light on ILPs in schistosomes, providing further insight into the distinct and specialised functions of SjIR1 and 2 in S. japonicum and their interaction with host insulin.
[Mh] Termos MeSH primário: Peptídeos e Proteínas de Sinalização Intercelular/genética
Peptídeos e Proteínas de Sinalização Intercelular/metabolismo
Schistosoma/genética
Schistosoma/fisiologia
[Mh] Termos MeSH secundário: Difosfato de Adenosina/metabolismo
Animais
Feminino
Hidrólise
Masculino
Ligação Proteica
Schistosoma/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Intercellular Signaling Peptides and Proteins); 61D2G4IYVH (Adenosine Diphosphate)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170425
[Lr] Data última revisão:
170425
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170415
[St] Status:MEDLINE
[do] DOI:10.1186/s13071-017-2095-7


  8 / 2673 MEDLINE  
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[PMID]:28383230
[Au] Autor:Skorpen PK; Thoresen H
[Ad] Endereço:Medisinsk avdeling Nordlandssykehuset Vesterålen.
[Ti] Título:A foreign man with headache and backache.
[Ti] Título:En utenlandsk mann med hodepine og ryggsmerter..
[So] Source:Tidsskr Nor Laegeforen;137(7):545-548, 2017 Apr.
[Is] ISSN:0807-7096
[Cp] País de publicação:Norway
[La] Idioma:eng; nor
[Mh] Termos MeSH primário: Esquistossomose
[Mh] Termos MeSH secundário: Adulto
África/etnologia
Animais
Anti-Helmínticos/administração & dosagem
Anti-Helmínticos/uso terapêutico
Dor nas Costas/parasitologia
Cefaleia/parasitologia
Seres Humanos
Imagem por Ressonância Magnética
Masculino
Meia-Idade
Noruega
Schistosoma/crescimento & desenvolvimento
Schistosoma/isolamento & purificação
Esquistossomose/diagnóstico
Esquistossomose/diagnóstico por imagem
Esquistossomose/tratamento farmacológico
Vértebras Torácicas/diagnóstico por imagem
Vértebras Torácicas/parasitologia
[Pt] Tipo de publicação:CASE REPORTS
[Nm] Nome de substância:
0 (Anthelmintics)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170904
[Lr] Data última revisão:
170904
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170407
[St] Status:MEDLINE
[do] DOI:10.4045/tidsskr.16.0568


  9 / 2673 MEDLINE  
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[PMID]:28381240
[Au] Autor:Balahbib A; Amarir F; Corstjens PL; de Dood CJ; van Dam GJ; Hajli A; Belhaddad M; El Mansouri B; Sadak A; Rhajaoui M; Adlaoui EB
[Ad] Endereço:National Reference Laboratory for Schistosomiasis and Malacology, National Institute of Hygiene, Agdal, Rabat, Morocco. balahbib.abdo@gmail.com.
[Ti] Título:Selecting accurate post-elimination monitoring tools to prevent reemergence of urogenital schistosomiasis in Morocco: a pilot study.
[So] Source:Infect Dis Poverty;6(1):75, 2017 Apr 06.
[Is] ISSN:2049-9957
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: After alleged stop of transmission of schistosomiasis and further down the line in post elimination settings, sensitive tools are required to monitor infection status to prevent potential re-emergence. In Rahala, where transmission cycle of Schistosoma haematobium is interrupted since 2004 but where 30% of snails are still infected by S. bovis, potential human S. bovis infection can't be excluded. As methods based on egg-counts do not provide the required sensitivity, antibody or antigen assays are envisaged as the most appropriate tools for this type of monitoring. METHODS: In this pilot study, the performances of three assays were compared: two commercially available antibody tests (ELISA and haemagglutination format) indicating exposure, and an antigen test (lateral flow strip format) demonstrating active infection. All 37 recruited study participants resided in Rahala (Akka, province Tata, Morocco). Participants had been diagnosed and cured from schistosomiasis in the period between 1983 and 2003. In 2015 these asymptomatic participants provided fresh clinical samples (blood and urine) for analysis with the aforementioned diagnostics tests. RESULTS: No eggs were identified in the urine of the 37 participants. The haemagglutination test indicated 6 antibody positives whereas the ELISA indicated 28 antibody positives, one indecisive and one false positive. ELISA and haemagglutination results matched for 18 individuals, amongst which 5 out of 6 haemagglutination positives. With the antigen test (performed on paired serum and urine samples), serum from two participants (cured 21 and 32 years ago) indicated the presence of low levels of the highly specific Schistosoma circulating anodic antigen (CAA), demonstrating low worm level infections (less than 5 pg/ml corresponding to probably single worm pair). One tested also CAA positive with urine. ELISA indicated the presence of human anti-Schistosoma antibodies in these two CAA positive cases, haemagglutination results were negative. CONCLUSIONS: To prevent reemergence of schistosomiasis in Morocco current monitoring programs require specific protocols that include testing of antibody positives for active infection by the UCP-LF CAA test, the appropriate diagnostic tool to identify Schistosoma low grade infections in travelers, immigrants and assumed cured cases. The test is genus specific will also identify infections related to S. bovis.
[Mh] Termos MeSH primário: Schistosoma/isolamento & purificação
Esquistossomose Urinária/diagnóstico
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Animais
Anticorpos Anti-Helmínticos/sangue
Anticorpos Anti-Helmínticos/urina
Antígenos de Helmintos/sangue
Antígenos de Helmintos/imunologia
Antígenos de Helmintos/urina
Criança
Erradicação de Doenças
Ensaio de Imunoadsorção Enzimática/métodos
Feminino
Testes de Hemaglutinação/métodos
Seres Humanos
Testes Imunológicos/métodos
Masculino
Meia-Idade
Marrocos
Contagem de Ovos de Parasitas
Projetos Piloto
Schistosoma/imunologia
Esquistossomose Urinária/imunologia
Esquistossomose Urinária/parasitologia
Esquistossomose Urinária/prevenção & controle
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Helminth); 0 (Antigens, Helminth)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170512
[Lr] Data última revisão:
170512
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170407
[St] Status:MEDLINE
[do] DOI:10.1186/s40249-017-0289-z


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[PMID]:28351414
[Au] Autor:Bergquist R; Utzinger J; Keiser J
[Ad] Endereço:Ingerod, Brastad, Sweden.
[Ti] Título:Controlling schistosomiasis with praziquantel: How much longer without a viable alternative?
[So] Source:Infect Dis Poverty;6(1):74, 2017 Mar 28.
[Is] ISSN:2049-9957
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The current approach of morbidity control of schistosomiasis, a helminth disease of poverty with considerable public health and socioeconomic impact, is based on preventive chemotherapy with praziquantel. There is a pressing need for new drugs against this disease whose control entirely depends on this single drug that has been widely used over the past 40 years. We argue that a broader anthelminthic approach supplementing praziquantel with new antischistosomals targeting different parasite development stages would not only increase efficacy but also reduce the risk for drug resistance. Repositioning drugs already approved for other diseases provides a shortcut to clinical trials, as it is expected that such drugs rapidly pass the regulatory authorities. The antischistosomal properties of antimalarial drugs (e.g., semisynthetic artemisinins, synthetic trioxolanes, trioxaquines and mefloquine) and of drugs being developed or registered for other purposes (e.g., moxidectin and miltefosin), administered alone or in combination with praziquantel, have been tested in the laboratory and clinical trials. Another avenue to follow is the continued search for new antischistosomal properties in plants. Here, we summarise recent progress made in schistosomiasis chemotherapy, placing particular emphasis on repositioning of existing drugs against schistosomiasis.
[Mh] Termos MeSH primário: Praziquantel/uso terapêutico
Esquistossomose/tratamento farmacológico
Esquistossomose/prevenção & controle
[Mh] Termos MeSH secundário: Animais
Anti-Helmínticos/farmacologia
Anti-Helmínticos/uso terapêutico
Antimaláricos/administração & dosagem
Antimaláricos/farmacologia
Antimaláricos/uso terapêutico
Reposicionamento de Medicamentos
Resistência a Medicamentos
Quimioterapia Combinada
Seres Humanos
Praziquantel/farmacologia
Saúde Pública
Schistosoma/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Anthelmintics); 0 (Antimalarials); 6490C9U457 (Praziquantel)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170411
[Lr] Data última revisão:
170411
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170330
[St] Status:MEDLINE
[do] DOI:10.1186/s40249-017-0286-2



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