Base de dados : MEDLINE
Pesquisa : B01.050.500.644.080.150 [Categoria DeCS]
Referências encontradas : 130 [refinar]
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  1 / 130 MEDLINE  
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[PMID]:28452031
[Au] Autor:Sudsandee S; Tantrakarnapa K; Tharnpoophasiam P; Limpanont Y; Mingkhwan R; Worakhunpiset S
[Ad] Endereço:Department of Social and Environmental Medicine, Faculty of Tropical Medicine, Mahidol University, 420/6 Ratchavithi Rd, Ratchathewi, Bangkok, 10400, Thailand.
[Ti] Título:Evaluating health risks posed by heavy metals to humans consuming blood cockles (Anadara granosa) from the Upper Gulf of Thailand.
[So] Source:Environ Sci Pollut Res Int;24(17):14605-14615, 2017 Jun.
[Is] ISSN:1614-7499
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:There is global concern about heavy metal contamination in the environment. Adverse health effects can be caused by heavy metals in contaminated food and water. Therefore, environmental monitoring studies and risk assessments should be conducted periodically. In this study, we measured levels of Cd, Cr, Cu, Hg, Mn, Ni, Pb, and Zn in blood cockles (Anadara granosa) collected from three locations in the Upper Gulf of Thailand. Hazard quotients and hazard indices were calculated to evaluate the health risks posed by heavy metals in consumed blood cockles. Heavy metal concentrations in all of the blood cockle samples were lower than the relevant food standards. The hazard quotients and hazard indices were <1 in all three sampling areas, indicating that adverse health effects were not likely to be caused by exposure to heavy metals in blood cockles over a human lifetime.
[Mh] Termos MeSH primário: Arcidae
Contaminação de Alimentos
Metais Pesados/toxicidade
Medição de Risco
Poluentes Químicos da Água/toxicidade
[Mh] Termos MeSH secundário: Animais
Cardiidae
Monitoramento Ambiental
Seres Humanos
Metais Pesados/análise
Alimentos Marinhos
Tailândia
Poluentes Químicos da Água/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Metals, Heavy); 0 (Water Pollutants, Chemical)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171215
[Lr] Data última revisão:
171215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1007/s11356-017-9014-5


  2 / 130 MEDLINE  
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[PMID]:28489869
[Au] Autor:Horn S; de la Vega C; Asmus R; Schwemmer P; Enners L; Garthe S; Binder K; Asmus H
[Ad] Endereço:Alfred-Wegener-Institut Helmholtz-Zentrum für Polar- und Meeresforschung, WaddenSea Station Sylt, List/ Sylt, Germany.
[Ti] Título:Interaction between birds and macrofauna within food webs of six intertidal habitats of the Wadden Sea.
[So] Source:PLoS One;12(5):e0176381, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The determination of food web structures using Ecological Network Analysis (ENA) is a helpful tool to get insight into complex ecosystem processes. The intertidal area of the Wadden Sea is structured into diverse habitat types which differ in their ecological functioning. In the present study, six different intertidal habitats (i.e. cockle field, razor clam field, mud flat, mussel bank, sand flat and seagrass meadow) were analyzed using ENA to determine similarities and characteristic differences in the food web structure of the systems. All six systems were well balanced between their degree of organization and their robustness. However, they differed in their detailed features. The cockle field and the mussel bank exhibited a strong dependency on external imports. The razor clam field appeared to be a rather small system with low energy transfer. In the mud flat microphytobenthos was used as a main food source and the system appeared to be sensitive to perturbations. Bird predation was the most pronounced in the sand flat and the seagrass meadow and led to an increase in energy transfer and parallel trophic cycles in these habitats. Habitat diversity appears to be an important trait for the Wadden Sea as each subsystem seems to have a specific role in the overall functioning of the entire ecosystem.
[Mh] Termos MeSH primário: Ecossistema
Cadeia Alimentar
Comportamento Predatório
[Mh] Termos MeSH secundário: Animais
Aves
Bivalves
Cardiidae
Oceanos e Mares
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170911
[Lr] Data última revisão:
170911
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170511
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0176381


  3 / 130 MEDLINE  
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[PMID]:28097482
[Au] Autor:Islam MN; Taki G; Nguyen XP; Jo YT; Kim J; Park JH
[Ad] Endereço:Department of Environment and Energy Engineering, Chonnam National University, Gwangju, 500-757, Republic of Korea.
[Ti] Título:Heavy metal stabilization in contaminated soil by treatment with calcined cockle shell.
[So] Source:Environ Sci Pollut Res Int;24(8):7177-7183, 2017 Mar.
[Is] ISSN:1614-7499
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:In several previous studies, the efficacy of various liming waste materials on the immobilization of heavy metals has been tested and it was found that soils contaminated with heavy metals can be stabilized using this technique. Since lime (CaO) has been identified as the main phase of calcined cockle shell (CCS), it was hypothesized that CCS could be used as a soil amendment to immobilize heavy metals in soil. However, to date, no studies have been conducted using CCS. In this study, the effectiveness of CCS powder on the immobilization of Cd, Pb, and Zn in mine tailing soil was evaluated. After 28 days of incubation, the treated soil samples were exposed to weathering (four cycles of freezing-thawing and four cycles of wetting-drying) for 8 days before being subjected to a leaching test. The results of this study revealed that the soil pH increased from 7.5 to 12.2 with the addition of 5% CCS. A similar soil pH was obtained when the soil was amended with 5% pure CaO. By leaching with 0.1 M HCl, extracted Cd, Pb, and Zn were reduced by up to 85, 85, and 91%, respectively. Therefore, CCS is suggested as a low-cost lime-based soil amendment for stabilizing heavy metals in abandoned mining sites.
[Mh] Termos MeSH primário: Exoesqueleto/química
Biodegradação Ambiental
Metais Pesados
Poluentes do Solo
[Mh] Termos MeSH secundário: Animais
Cardiidae
Metais Pesados/análise
Metais Pesados/química
Metais Pesados/isolamento & purificação
Poluentes do Solo/análise
Poluentes do Solo/química
Poluentes do Solo/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Metals, Heavy); 0 (Soil Pollutants)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:171104
[Lr] Data última revisão:
171104
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170119
[St] Status:MEDLINE
[do] DOI:10.1007/s11356-016-8330-5


  4 / 130 MEDLINE  
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[PMID]:28000604
[Au] Autor:Carballal MJ; Iglesias D; Darriba S; Cao A; Mariño JC; Ramilo A; No E; Villalba A
[Ad] Endereço:Centro de Investigacións Mariñas (CIMA), Consellería do Mar, Xunta de Galicia, 36620 Vilanova de Arousa, Spain.
[Ti] Título:Parasites, pathological conditions and resistance to Marteilia cochillia in lagoon cockle Cerastoderma glaucum from Galicia (NW Spain).
[So] Source:Dis Aquat Organ;122(2):137-152, 2016 12 21.
[Is] ISSN:0177-5103
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:A histopathological survey revealed parasites and pathological conditions affecting lagoon cockles Cerastoderma glaucum along the Galician coast; serious pathological threats were not detected because the potentially pathogenic conditions (infections with a Marteilia-like parasite and bucephalid sporocysts, disseminated neoplasia and a condition involving large foci of heavy haemocytic reaction) were rare, while more prevalent parasites had negligible or limited pathogeny. Considering that C. edule and C. glaucum are sympatric in some Galician rias, it is remarkable that C. glaucum was not seriously affected by Marteilia cochillia while C. edule suffered an intense outbreak of this parasite associated with massive mortality. Comparison of the digestive gland between cockle species showed co-occurrence of digestive tubules in different phases, with abundant disintegrated tubules, in the case of C. glaucum, while C. edule showed synchronicity and absence of fully disintegrated tubules; these differences could influence their susceptibility to M. cochillia because the main location of this parasite in common cockles is the epithelia of the digestive gland. Moreover, the observation of histological sections through the digestive gland easily allows differentiating the 2 cockle species.
[Mh] Termos MeSH primário: Bactérias/classificação
Cardiidae/microbiologia
Cardiidae/parasitologia
Eucariotos/fisiologia
Fungos/fisiologia
[Mh] Termos MeSH secundário: Animais
Interações Hospedeiro-Parasita
Interações Hospedeiro-Patógeno
Espanha
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170629
[Lr] Data última revisão:
170629
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161222
[St] Status:MEDLINE
[do] DOI:10.3354/dao03070


  5 / 130 MEDLINE  
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[PMID]:27811708
[Au] Autor:Perna R
[Ad] Endereço:Dipartimento di Scienze Geologiche e GeoAmbientali, Università di Bari, Via Orabona 4, 70125 Bari, Italy.; Email: rafael.laperna@uniba.it.
[Ti] Título:Bucardium grateloupianum n. sp. from the Lower Miocene of Aquitaine with    taxonomic comments on some fossil species from Europe (Bivalvia, Cardiidae).
[So] Source:Zootaxa;4178(4):568-582, 2016 Oct 26.
[Is] ISSN:1175-5334
[Cp] País de publicação:New Zealand
[La] Idioma:eng
[Ab] Resumo:The genus Bucardium J. E. Gray, 1853 has been widely used in the past literature, either for living and fossil cardiids, but only a single species was known, its type species B. ringens (Bruguière, 1789), living in the tropical waters of West Africa. Another species, from the Lower Miocene of the Aquitaine Basin, turned out to be undescribed, though known since the 19th century. It is herein described as Bucardium grateloupianum n. sp. The genus seems to have always had a low diversity and a tropical distribution. Its disappearance in Europe coincides with the general cooling trend recorded after the Middle Miocene. Several poorly known cardiids from the Lower-Middle Miocene of France and Austria and from the Upper Oligocene of Hungary show closer morphological affinities with the living Cardium indicum Lamarck, 1819, rather than with the genus Bucardium or with Cardium costatum Linnaeus, 1758, the type species of Cardium Linnaeus, 1758. These affinities suggest the need of a systematic reappraisal of the living and fossil species currently assigned to Cardium.
[Mh] Termos MeSH primário: Cardiidae/anatomia & histologia
Cardiidae/classificação
[Mh] Termos MeSH secundário: Exoesqueleto/anatomia & histologia
Animais
Fósseis
França
Especificidade da Espécie
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170418
[Lr] Data última revisão:
170418
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161105
[St] Status:MEDLINE
[do] DOI:10.11646/zootaxa.4178.4.7


  6 / 130 MEDLINE  
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[PMID]:27494189
[Au] Autor:Navarro E; Méndez S; Urrutia MB; Arambalza U; Ibarrola I
[Ad] Endereço:Departamento GAFFA (Fisiología Animal), Facultad de Ciencia y Tecnología, Universidad del País Vasco/Euskal Herriko Unibertsitatea, Apartado 644, 48080, Bilbao, Spain. Electronic address: enrique.navarro@ehu.es.
[Ti] Título:Digestive selection underlies differential utilization of phytoplankton and sedimentary organics by infaunal bivalves: Experiments with cockles (Cerastoderma edule) using cross-labelled mixed diets.
[So] Source:Mar Environ Res;120:111-21, 2016 Sep.
[Is] ISSN:1879-0291
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Differential utilization of phytoplankton and detrital particles present in natural sediments of mud-flats was studied in a series of experiments performed on the infaunal bivalve Cerastoderma edule. In order to assess digestive selection, parameters of food processing (organic ingestion rate: OIR, gross absorption efficiency: GAE and gut passage time: GPT) were recorded for each organic component in different combinations of food particles radio-labelled with (14)C. Experimental design included the use of both labelled diets of a sole organic component and cross-labelled diets; i.e., mixed suspensions presenting alternatively labelled one of the various components tested: phytoplankton cells, sedimentary organic particles and particulate detritus from vascular salt-marsh plants. Preferential absorption of phytoplankton was accounted for by absorption efficiency values that were two-fold those for sedimentary detritus when recorded with mixed diets of both organic components. Two factors contributed to this difference: a) higher digestibility of microalgae, measured as the ratio of GAE to GPT, and b) faster gut passage of detrital particles that results from digestive selection likely involving the preferential incorporation of phytoplankton into the digestive gland. However, when diets based on a sole organic component (either phytoplankton or detritus) were compared, larger GPT were recorded for detrital particles that enabled improving GAE of this rather refractory food. Overall results of these experiments are consistent with most studies in trophic ecology based on stable isotopes enrichment, concerning both the diversity of trophic sources used by marine bivalves and its preferential utilization of phytoplankton over phyto-detritus.
[Mh] Termos MeSH primário: Cardiidae/fisiologia
Dieta
Monitoramento Ambiental
Sedimentos Geológicos/análise
Fitoplâncton
[Mh] Termos MeSH secundário: Animais
Bivalves
Digestão
Ingestão de Alimentos
Frutos do Mar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170309
[Lr] Data última revisão:
170309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160806
[St] Status:MEDLINE


  7 / 130 MEDLINE  
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[PMID]:27401811
[Au] Autor:Villaverde-de-Sáa E; Rodil R; Quintana JB; Cela R
[Ad] Endereço:Department of Analytical Chemistry, Nutrition and Food Science, IIAA-Institute for Food Analysis and Research, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain.
[Ti] Título:Matrix solid-phase dispersion combined to liquid chromatography-tandem mass spectrometry for the determination of paraben preservatives in mollusks.
[So] Source:J Chromatogr A;1459:57-66, 2016 Aug 12.
[Is] ISSN:1873-3778
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:A method for the extraction and determination of seven parabens, esters of 4-hydroxybenzoic acid, widely used as preservatives in personal care products, pharmaceuticals, etc., and two chlorinated derivatives (mono- and di-chloro methyl paraben) from mollusk samples was developed by combining matrix solid-phase dispersion (MSPD) and liquid chromatography-tandem mass spectrometry. MSPD parameters, such as solvent, solid support and clean-up sorbent, were optimized. Besides, since blank problems were observed for some parabens, these were investigated and blanks were tackled by precleaning all sorbents prior to use. Under final conditions, 0.5g of freeze-dried mollusk were dispersed with 1.2g of silica and packed into a cartridge containing 3g of C18, as on-line clean-up sorbent. This cartridge was eluted with 10mL of acetonitrile, evaporated and reconstituted in methanol for analysis. In the validation stage, successful linearity (R(2)>0.999), recoveries (between 71 and 117% for most analytes), precision (RSD lower than 21%) and limits of detection and quantification (LOD and LOQ, lower than 0.4 and 1.4ngg(-1) dry weight respectively) levels were achieved. Finally, the new methodology was applied to mussel, clam and cockle samples. Methyl paraben was above the LOQ in five of the six samples (not found in one clam sample) at concentrations up to 7ngg(-1) dry weight. Ethyl paraben was found above the LOQ in mussel and cockle samples at a concentration level around 0.3ngg(-1). n-Propyl paraben was only above the LOQ in one mussel sample.
[Mh] Termos MeSH primário: Cromatografia Líquida de Alta Pressão
Moluscos/química
Parabenos/análise
Conservantes Farmacêuticos/análise
Espectrometria de Massas em Tandem
[Mh] Termos MeSH secundário: Acetonitrilos/química
Animais
Bivalves/química
Bivalves/metabolismo
Cardiidae/química
Cardiidae/metabolismo
Limite de Detecção
Moluscos/metabolismo
Parabenos/isolamento & purificação
Conservantes Farmacêuticos/isolamento & purificação
Extração em Fase Sólida
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acetonitriles); 0 (Parabens); 0 (Preservatives, Pharmaceutical); Z072SB282N (acetonitrile)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:170806
[Lr] Data última revisão:
170806
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160713
[St] Status:MEDLINE


  8 / 130 MEDLINE  
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[PMID]:27285613
[Au] Autor:Milano S; Schöne BR; Wang S; Müller WE
[Ad] Endereço:Institute of Geosciences, University of Mainz, Joh.-J.-Becherweg 21, 55128, Mainz, Germany. Electronic address: smilano@uni-mainz.de.
[Ti] Título:Impact of high pCO2 on shell structure of the bivalve Cerastoderma edule.
[So] Source:Mar Environ Res;119:144-55, 2016 Aug.
[Is] ISSN:1879-0291
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Raised atmospheric emissions of carbon dioxide (CO2) result in an increased ocean pCO2 level and decreased carbonate saturation state. Ocean acidification potentially represents a major threat to calcifying organisms, specifically mollusks. The present study focuses on the impact of elevated pCO2 on shell microstructural and mechanical properties of the bivalve Cerastoderma edule. The mollusks were collected from the Baltic Sea and kept in flow-through systems at six different pCO2 levels from 900 µatm (control) to 24,400 µatm. Extreme pCO2 levels were used to determine the effects of potential leaks from the carbon capture and sequestration sites where CO2 is stored in sub-seabed geological formations. Two approaches were combined to determine the effects of the acidified conditions: (1) Shell microstructures and dissolution damage were analyzed using scanning electron microscopy (SEM) and (2) shell hardness was tested using nanoindentation. Microstructures of specimens reared at different pCO2 levels do not show significant changes in their size and shape. Likewise, the increase of pCO2 does not affect shell hardness. However, dissolution of ontogenetically younger portions of the shell becomes more severe with the increase of pCO2. Irrespective of pCO2, strong negative correlations exist between microstructure size and shell mechanics. An additional sample from the North Sea revealed the same microstructural-mechanical interdependency as the shells from the Baltic Sea. Our findings suggest that the skeletal structure of C. edule is not intensely influenced by pCO2 variations. Furthermore, our study indicates that naturally occurring shell mechanical property depends on the shell architecture at µm-scale.
[Mh] Termos MeSH primário: Exoesqueleto/química
Dióxido de Carbono/análise
Cardiidae/fisiologia
Monitoramento Ambiental
Água do Mar/química
[Mh] Termos MeSH secundário: Exoesqueleto/fisiologia
Animais
Carbonatos
Concentração de Íons de Hidrogênio
Mar do Norte
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Carbonates); 142M471B3J (Carbon Dioxide)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170302
[Lr] Data última revisão:
170302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160611
[St] Status:MEDLINE


  9 / 130 MEDLINE  
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[PMID]:27053747
[Au] Autor:Bijleveld AI; MacCurdy RB; Chan YC; Penning E; Gabrielson RM; Cluderay J; Spaulding EL; Dekinga A; Holthuijsen S; ten Horn J; Brugge M; van Gils JA; Winkler DW; Piersma T
[Ad] Endereço:NIOZ Royal Netherlands Institute for Sea Research, Department of Coastal Systems, and Utrecht University, PO Box 59, 1790 AB Den Burg, The Netherlands allert.bijleveld@nioz.nl.
[Ti] Título:Understanding spatial distributions: negative density-dependence in prey causes predators to trade-off prey quantity with quality.
[So] Source:Proc Biol Sci;283(1828), 2016 Apr 13.
[Is] ISSN:1471-2954
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Negative density-dependence is generally studied within a single trophic level, thereby neglecting its effect on higher trophic levels. The 'functional response' couples a predator's intake rate to prey density. Most widespread is a type II functional response, where intake rate increases asymptotically with prey density; this predicts the highest predator densities at the highest prey densities. In one of the most stringent tests of this generality to date, we measured density and quality of bivalve prey (edible cockles Cerastoderma edule) across 50 km² of mudflat, and simultaneously, with a novel time-of-arrival methodology, tracked their avian predators (red knots Calidris canutus). Because of negative density-dependence in the individual quality of cockles, the predicted energy intake rates of red knots declined at high prey densities (a type IV, rather than a type II functional response). Resource-selection modelling revealed that red knots indeed selected areas of intermediate cockle densities where energy intake rates were maximized given their phenotype-specific digestive constraints (as indicated by gizzard mass). Because negative density-dependence is common, we question the current consensus and suggest that predators commonly maximize their energy intake rates at intermediate prey densities. Prey density alone may thus poorly predict intake rates, carrying capacity and spatial distributions of predators.
[Mh] Termos MeSH primário: Cardiidae/fisiologia
Charadriiformes/fisiologia
Comportamento Alimentar
Cadeia Alimentar
Comportamento Predatório
[Mh] Termos MeSH secundário: Distribuição Animal
Animais
Ingestão de Energia
Modelos Biológicos
Países Baixos
Densidade Demográfica
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1612
[Cu] Atualização por classe:170413
[Lr] Data última revisão:
170413
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160408
[St] Status:MEDLINE


  10 / 130 MEDLINE  
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[PMID]:26929622
[Au] Autor:Saidykhan L; Abu Bakar MZ; Rukayadi Y; Kura AU; Latifah SY
[Ad] Endereço:Microbiology Unit, Laboratory of Natural Products, Institute of Bioscience, Universiti Putra Malaysia, Serdang, Selangor Darul Ehsan, Malaysia.
[Ti] Título:Development of nanoantibiotic delivery system using cockle shell-derived aragonite nanoparticles for treatment of osteomyelitis.
[So] Source:Int J Nanomedicine;11:661-73, 2016.
[Is] ISSN:1178-2013
[Cp] País de publicação:New Zealand
[La] Idioma:eng
[Ab] Resumo:A local antibiotic delivery system (LADS) with biodegradable drug vehicles is recognized as the most effective therapeutic approach for the treatment of osteomyelitis. However, the design of a biodegradable LADS with high therapeutic efficacy is too costly and demanding. In this research, a low-cost, facile method was used to design vancomycin-loaded aragonite nanoparticles (VANPs) with the aim of understanding its potency in developing a nanoantibiotic bone implant for the treatment of osteomyelitis. The aragonite nanoparticles (ANPs) were synthesized from cockle shells by a hydrothermal approach using a zwitterionic surfactant. VANPs were prepared using antibiotic ratios of several nanoparticles, and the formulation (1:4) with the highest drug-loading efficiency (54.05%) was used for physicochemical, in vitro drug release, and biological evaluation. Physiochemical characterization of VANP was performed by using transmission electron microscopy, Fourier transform infrared spectroscopy, X-ray powder diffraction, and Zetasizer. No significant differences were observed between VANP and ANP in terms of size and morphology as both samples were cubic shaped with sizes of approximately 35 nm. The Fourier transform infrared spectroscopy of VANP indicated a weak noncovalent interaction between ANP and vancomycin, while the zeta potential values were slightly increased from -19.4±3.3 to -21.2±5.7 mV after vancomycin loading. VANP displayed 120 hours (5 days) release profile of vancomycin that exhibited high antibacterial effect against methicillin-resistant Staphylococcus aureus ATCC 29213. The cell proliferation assay showed 80% cell viability of human fetal osteoblast cell line 1.19 treated with the highest concentration of VANP (250 µg/mL), indicating good biocompatibility of VANP. In summary, VANP is a potential formulation for the development of an LADS against osteomyelitis with optimal antibacterial efficacy, good bone resorbability, and biocompatibility.
[Mh] Termos MeSH primário: Exoesqueleto/química
Antibacterianos/farmacologia
Carbonato de Cálcio/química
Cardiidae/química
Nanopartículas/química
Osteomielite/tratamento farmacológico
Vancomicina/farmacologia
[Mh] Termos MeSH secundário: Animais
Antibacterianos/química
Células Cultivadas
Química Farmacêutica
Portadores de Fármacos
Sistemas de Liberação de Medicamentos
Feto/efeitos dos fármacos
Seres Humanos
Testes de Sensibilidade Microbiana
Nanopartículas/administração & dosagem
Osteoblastos/citologia
Osteoblastos/efeitos dos fármacos
Osteomielite/patologia
Espectroscopia de Infravermelho com Transformada de Fourier
Staphylococcus aureus/efeitos dos fármacos
Vancomicina/química
Difração de Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Drug Carriers); 6Q205EH1VU (Vancomycin); H0G9379FGK (Calcium Carbonate)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160302
[St] Status:MEDLINE
[do] DOI:10.2147/IJN.S95885



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