Base de dados : MEDLINE
Pesquisa : B01.050.500.644.080.535 [Categoria DeCS]
Referências encontradas : 69 [refinar]
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  1 / 69 MEDLINE  
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[PMID]:27068305
[Au] Autor:Arivalagan J; Marie B; Sleight VA; Clark MS; Berland S; Marie A
[Ad] Endereço:UMR 7245 CNRS/MNHN Molécules de Communications et Adaptations des Micro-organismes, Sorbonne Universités, Muséum National d'Histoire Naturelle, Paris, France; UMR 7208 CNRS/MNHN/UPMC/IRD Biologie des Organismes Aquatiques et Ecosystèmes, Sorbonne Universités, Muséum National d'Histoire Naturelle, Pa
[Ti] Título:Shell matrix proteins of the clam, Mya truncata: Roles beyond shell formation through proteomic study.
[So] Source:Mar Genomics;27:69-74, 2016 Jun.
[Is] ISSN:1876-7478
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Mya truncata, a soft shell clam, is presented as a new model to study biomineralization through a proteomics approach. In this study, the shell and mantle tissue were analysed in order to retrieve knowledge about the secretion of shell matrix proteins (SMPs). Out of 67 and 127 shell and mantle proteins respectively, 16 were found in both shell and mantle. Bioinformatic analysis of SMP sequences for domain prediction revealed the presence of several new domains such as fucolectin tachylectin-4 pentraxin-1 (FTP), scavenger receptor, alpha-2-macroglobulin (α2 M), lipocalin and myosin tail along with previously reported SMP domains such as chitinase, carbonic anhydrase, tyrosinase, sushi, and chitin binding. Interestingly, these newly predicted domains are attributed with molecular functions other than biomineralization. These findings suggest that shells may not only act as protective armour from predatory action, but could also actively be related to other functions such as immunity. In this context, the roles of SMPs in biomineralization need to be looked in a new perspective.
[Mh] Termos MeSH primário: Exoesqueleto/crescimento & desenvolvimento
Mya/genética
Proteoma
[Mh] Termos MeSH secundário: Exoesqueleto/metabolismo
Animais
Calcificação Fisiológica
Mya/crescimento & desenvolvimento
Mya/metabolismo
Proteômica
Escócia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Proteome)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170512
[Lr] Data última revisão:
170512
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160413
[St] Status:MEDLINE


  2 / 69 MEDLINE  
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[PMID]:26806806
[Au] Autor:Vendrami DL; Shah A; Telesca L; Hoffman JI
[Ad] Endereço:Department of Animal Behaviour, University of Bielefeld, Postfach 100131, 33501 Bielefeld, Germany. Electronic address: david.vendrami@student.unife.it.
[Ti] Título:Mining the transcriptomes of four commercially important shellfish species for single nucleotide polymorphisms within biomineralization genes.
[So] Source:Mar Genomics;27:17-23, 2016 Jun.
[Is] ISSN:1876-7478
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Transcriptional profiling not only provides insights into patterns of gene expression, but also generates sequences that can be mined for molecular markers, which in turn can be used for population genetic studies. As part of a large-scale effort to better understand how commercially important European shellfish species may respond to ocean acidification, we therefore mined the transcriptomes of four species (the Pacific oyster Crassostrea gigas, the blue mussel Mytilus edulis, the great scallop Pecten maximus and the blunt gaper Mya truncata) for single nucleotide polymorphisms (SNPs). Illumina data for C. gigas, M. edulis and P. maximus and 454 data for M. truncata were interrogated using GATK and SWAP454 respectively to identify between 8267 and 47,159 high quality SNPs per species (total=121,053 SNPs residing within 34,716 different contigs). We then annotated the transcripts containing SNPs to reveal homology to diverse genes. Finally, as oceanic pH affects the ability of organisms to incorporate calcium carbonate, we honed in on genes implicated in the biomineralization process to identify a total of 1899 SNPs in 157 genes. These provide good candidates for biomarkers with which to study patterns of selection in natural or experimental populations.
[Mh] Termos MeSH primário: Bivalves/genética
Polimorfismo de Nucleotídeo Único
Transcriptoma
[Mh] Termos MeSH secundário: Exoesqueleto/crescimento & desenvolvimento
Animais
Bivalves/crescimento & desenvolvimento
Bivalves/metabolismo
Calcificação Fisiológica
Crassostrea/genética
Crassostrea/crescimento & desenvolvimento
Crassostrea/metabolismo
Mya/genética
Mya/crescimento & desenvolvimento
Mya/metabolismo
Mytilus edulis/genética
Mytilus edulis/crescimento & desenvolvimento
Mytilus edulis/metabolismo
Pecten/genética
Pecten/crescimento & desenvolvimento
Pecten/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170512
[Lr] Data última revisão:
170512
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160126
[St] Status:MEDLINE


  3 / 69 MEDLINE  
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[PMID]:26777791
[Au] Autor:Sleight VA; Thorne MA; Peck LS; Arivalagan J; Berland S; Marie A; Clark MS
[Ad] Endereço:British Antarctic Survey, Natural Environment Research Council, High Cross, Madingley Road, Cambridge CB3 0ET, UK. Electronic address: viceig15@bas.ac.uk.
[Ti] Título:Characterisation of the mantle transcriptome and biomineralisation genes in the blunt-gaper clam, Mya truncata.
[So] Source:Mar Genomics;27:47-55, 2016 Jun.
[Is] ISSN:1876-7478
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Members of the Myidae family are ecologically and economically important, but there is currently very little molecular data on these species. The present study sequenced and assembled the mantle transcriptome of Mya truncata from the North West coast of Scotland and identified candidate biomineralisation genes. RNA-Seq reads were assembled to create 20,106 contigs in a de novo transciptome, 18.81% of which were assigned putative functions using BLAST sequence similarity searching (cuttoff E-value 1E-10). The most highly expressed genes were compared to the Antarctic clam (Laternula elliptica) and showed that many of the dominant biological functions (muscle contraction, energy production, biomineralisation) in the mantle were conserved. There were however, differences in the constitutive expression of heat shock proteins, which were possibly due to the M. truncata sampling location being at a relatively low latitude, and hence relatively warm, in terms of the global distribution of the species. Phylogenetic analyses of the Tyrosinase proteins from M. truncata showed a gene expansion which was absent in L. elliptica. The tissue distribution expression patterns of putative biomineralisation genes were investigated using quantitative PCR, all genes showed a mantle specific expression pattern supporting their hypothesised role in shell secretion. The present study provides some preliminary insights into how clams from different environments - temperate versus polar - build their shells. In addition, the transcriptome data provides a valuable resource for future comparative studies investigating biomineralisation.
[Mh] Termos MeSH primário: Exoesqueleto/crescimento & desenvolvimento
Mya/crescimento & desenvolvimento
Mya/genética
Transcriptoma
[Mh] Termos MeSH secundário: Animais
Calcificação Fisiológica
Anotação de Sequência Molecular
Mya/metabolismo
Análise de Sequência de DNA
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170512
[Lr] Data última revisão:
170512
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160119
[St] Status:MEDLINE


  4 / 69 MEDLINE  
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[PMID]:26687447
[Au] Autor:Mateo DR; MacCallum GS; Davidson J
[Ad] Endereço:Department of Pathology and Microbiology, Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, PE, Canada.
[Ti] Título:Field and laboratory transmission studies of haemic neoplasia in the soft-shell clam, Mya arenaria, from Atlantic Canada.
[So] Source:J Fish Dis;39(8):913-27, 2016 Aug.
[Is] ISSN:1365-2761
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A two-year laboratory and field study was initiated in 2001 in response to mass mortalities associated with haemic neoplasia (HN) in 1999 in Prince Edward Island (PEI) soft-shell clams, Mya arenaria. A laboratory proximity experiment (cohabitation) and an inoculation challenge were conducted with clams and mussels (Mytilus edulis). Three field exposure experiments were also conducted, in which naive clams were held in sediment (in trays) or out of sediment (in mesh bags) at three high HN prevalence sites on PEI. There was a conversion to HN positive in clams in the proximity experiment and in clams injected with whole blood and cell-free homogenate, but not at statistically significant levels. No mussels or control clams became HN positive. There was a significant conversion to HN positive in as little as 24 and 58 days after transfer with clams held out of sediment and in sediment, respectively. The laboratory and field experiments' results suggest that HN-infected clams are spreading the disease through water from infected clams to naïve individuals and via transplantation from affected to unaffected sites. Some environmental conditions (e.g. abnormally high water temperature and hypoxia-induced sea lettuce [Ulva lacteus] invasion) may make clams susceptible to infections or exacerbate the proliferation of HN.
[Mh] Termos MeSH primário: Mya/fisiologia
[Mh] Termos MeSH secundário: Animais
Aquicultura
Hemócitos/patologia
Hemolinfa/fisiologia
Mya/citologia
Mytilus edulis
Ilha do Príncipe Eduardo
Água do Mar/química
Ulva/crescimento & desenvolvimento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170424
[Lr] Data última revisão:
170424
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151222
[St] Status:MEDLINE
[do] DOI:10.1111/jfd.12426


  5 / 69 MEDLINE  
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[PMID]:26686413
[Au] Autor:Ostrander EA; Davis BW; Ostrander GK
[Ad] Endereço:National Human Genome Research Institute, National Institutes of Health, 50 South Drive, Building 50 Room 5351, Bethesda MD 20892, USA. Electronic address: eostrand@mail.nih.gov.
[Ti] Título:Transmissible Tumors: Breaking the Cancer Paradigm.
[So] Source:Trends Genet;32(1):1-15, 2016 Jan.
[Is] ISSN:0168-9525
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Transmissible tumors are those that have transcended the bounds of their incipient hosts by evolving the ability to infect another individual through direct transfer of cancer cells, thus becoming parasitic cancer clones. Coitus, biting, and scratching are transfer mechanisms for the two primary species studied, the domestic dog (Canis lupus familiaris) and the Tasmanian devil (Sarcophilus harrisii). Canine transmissible venereal tumors (CTVT) are likely thousands of years old, and have successfully travelled from host to host around the world, while the Tasmanian devil facial tumor disease (DFTD) is much younger and geographically localized. The dog tumor is not necessarily lethal, while the devil tumor has driven the population to near extinction. Transmissible tumors are uniform in that they have complex immunologic profiles, which allow them to escape immune detection by their hosts, sometimes for long periods of time. In this review, we explore how transmissible tumors in CTVT, DFTD, and as well as the soft-shell clam and Syrian hamster, can advance studies of tumor biology.
[Mh] Termos MeSH primário: Doenças do Cão/transmissão
Neoplasias Faciais/veterinária
Neoplasias/veterinária
Tumores Venéreos Veterinários
[Mh] Termos MeSH secundário: Animais
Evolução Biológica
Cães
Variação Genética
Marsupiais
Mesocricetus
Mya
Neoplasias/genética
Neoplasias/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., INTRAMURAL; REVIEW
[Em] Mês de entrada:1612
[Cu] Atualização por classe:170101
[Lr] Data última revisão:
170101
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151222
[St] Status:MEDLINE


  6 / 69 MEDLINE  
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[PMID]:26123078
[Au] Autor:Mateo DR; MacCallum GS; McGladdery SE; Davidson J
[Ad] Endereço:Department of Pathology and Microbiology, Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, PE, Canada.
[Ti] Título:Distribution of haemic neoplasia of soft-shelled clams in Prince Edward Island: an examination of anthropogenic factors and effects of experimental fungicide exposure.
[So] Source:J Fish Dis;39(5):585-96, 2016 May.
[Is] ISSN:1365-2761
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Haemic neoplasia was first considered a disease of concern for soft-shell clams in Prince Edward Island (PEI) when it was diagnosed as the cause of mass mortalities in 1999. The aetiology of the disease remains elusive, but has been associated with environmental degradation. In this study, a 2-year (2001-2002) geographic and seasonal survey was conducted for haemic neoplasia, using histology, in soft-shell clams from PEI. In addition, using geographic information system, the association between anthropogenic factors in the watersheds at sites affected by haemic neoplasia and the prevalence of the disease was investigated. Finally, histopathological changes were assessed in soft-shell clams experimentally exposed to four concentrations of chlorothalonil for 27 days. Haemic neoplasia could not be induced at any concentration of chlorothalonil. Clams exposed to a concentration of 1000 µg L(-1) of the fungicide, however, exhibited an LC50 of 17 days. Although this information provides additional toxicity information (LC50) for soft-shell clams, further experiments are required to assess longer term exposure to the fungicide. The highest prevalences of haemic neoplasia in PEI were found in North River and Miscouche (28.3-50.9% and 33.0-77.8%, respectively). No clear seasonal patterns were found. There was a correlation between haemic neoplasia prevalence and watersheds with a high percentage of potato acreage and forest coverage (P = 0.026 and P = 0.045, respectively), suggesting a link between anthropogenic activity and the prevalence of the disease.
[Mh] Termos MeSH primário: Mya/efeitos dos fármacos
Nitrilos/toxicidade
[Mh] Termos MeSH secundário: Animais
Hemócitos/efeitos dos fármacos
Hemócitos/patologia
Dose Letal Mediana
Mya/citologia
Ilha do Príncipe Eduardo
Poluentes Químicos da Água/toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Nitriles); 0 (Water Pollutants, Chemical); J718M71A7A (tetrachloroisophthalonitrile)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150701
[St] Status:MEDLINE
[do] DOI:10.1111/jfd.12394


  7 / 69 MEDLINE  
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[PMID]:26582522
[Au] Autor:Yin TT; Wang L; Wang GD
[Ad] Endereço:1. Molecular Evolution and Genome Diversity Lab, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China; 2. Kunming College of Life Science, University of Chinese Academy of Sciences,Kunming 650204, China;
[Ti] Título:[Recent advances in transmissible tumors].
[So] Source:Yi Chuan;37(11):1086-94, 2015 11.
[Is] ISSN:0253-9772
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:Transmissible tumors are a class of tumor that can be transmitted between individuals through living cells. So far, four types of transmissible tumors including canine transmissible venereal tumor (CTVT),Tasmanian devil facial tumor disease (DFTD), soft-shell clams leukemia (SSCL), and hamsters reticulum cell sarcoma (HRCS)have been discovered and identified. In the last decades, these transmissible tumors have been proved to be transmitted through living cells by cytological, histological and genetic studies. CTVT, the oldest mammalian somatic cell line, and DFTD originated from Schwann cell have been reported to avoid immunological recognition by down-regulating MHC expression, while a high copy number of Steamer retrotransposon is commonly exist in SSCL. In recent years, the whole-genome sequencing of CTVT and DFTD have been completed which facilitates studies on the mechanisms of tumorigenesis, transmission and evolution of transmissible tumors at the whole-genome level. In this review, we summarize the recent advances in transmissible tumors and discuss the research focus in next decade.
[Mh] Termos MeSH primário: Doenças do Cão/genética
Leucemia/veterinária
Linfoma não Hodgkin/veterinária
Mya
Tumores Venéreos Veterinários/genética
[Mh] Termos MeSH secundário: Animais
Cricetinae
Cães
Seres Humanos
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Em] Mês de entrada:1601
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151120
[St] Status:MEDLINE
[do] DOI:10.16288/j.yczz.15-177


  8 / 69 MEDLINE  
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[PMID]:25993002
[Au] Autor:Harding JM; Segal MR; Reynolds JD
[Ad] Endereço:Earth to Ocean Research Group, Department of Biological Sciences, Simon Fraser University, Burnaby, BC, Canada; The Hakai Institute, Heriot Bay, BC, Canada.
[Ti] Título:Location is everything: evaluating the effects of terrestrial and marine resource subsidies on an estuarine bivalve.
[So] Source:PLoS One;10(5):e0125167, 2015.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Estuaries are amongst the world's most productive ecosystems, lying at the intersection between terrestrial and marine environments. They receive substantial inputs from adjacent landscapes but the importance of resource subsidies is not well understood. Here, we test hypotheses for the effects of both terrestrial- and salmon-derived resource subsidies on the diet (inferred from stable isotopes of muscle tissue), size and percent nitrogen of the soft-shell clam (Mya arenaria), a sedentary estuarine consumer. We examine how these relationships shift across natural gradients among 14 estuaries that vary in upstream watershed size and salmon density on the central coast of British Columbia, Canada. We also test how assimilation and response to subsidies vary at smaller spatial scales within estuaries. The depletion and enrichment of stable isotope ratios in soft-shell clam muscle tissue correlated with increasing upstream watershed size and salmon density, respectively. The effects of terrestrial- and salmon-derived subsidies were also strongest at locations near stream outlets. When we controlled for age of individual clams, there were larger individuals with higher percent nitrogen content in estuaries below larger watersheds, though this effect was limited to the depositional zones below river mouths. Pink salmon exhibited a stronger effect on isotope ratios of clams than chum salmon, which could reflect increased habitat overlap as spawning pink salmon concentrate in lower stream reaches, closer to intertidal clam beds. However, there were smaller clams in estuaries that had higher upstream pink salmon densities, possibly due to differences in habitat requirements. Our study highlights the importance of upstream resource subsidies to this bivalve species, but that individual responses to subsidies can vary at smaller scales within estuaries.
[Mh] Termos MeSH primário: Ecossistema
Estuários
Mya
[Mh] Termos MeSH secundário: Animais
Colúmbia Britânica
Isótopos de Carbono/metabolismo
Dieta
Cadeia Alimentar
Músculos/metabolismo
Mya/metabolismo
Isótopos de Nitrogênio/metabolismo
Oncorhynchus keta/metabolismo
Salmão/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Carbon Isotopes); 0 (Nitrogen Isotopes)
[Em] Mês de entrada:1604
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150521
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0125167


  9 / 69 MEDLINE  
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[PMID]:25860608
[Au] Autor:Metzger MJ; Reinisch C; Sherry J; Goff SP
[Ad] Endereço:Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA.
[Ti] Título:Horizontal transmission of clonal cancer cells causes leukemia in soft-shell clams.
[So] Source:Cell;161(2):255-63, 2015 Apr 09.
[Is] ISSN:1097-4172
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Outbreaks of fatal leukemia-like cancers of marine bivalves throughout the world have led to massive population loss. The cause of the disease is unknown. We recently identified a retrotransposon, Steamer, that is highly expressed and amplified to high copy number in neoplastic cells of soft-shell clams (Mya arenaria). Through analysis of Steamer integration sites, mitochondrial DNA single-nucleotide polymorphisms (SNPs), and polymorphic microsatellite alleles, we show that the genotypes of neoplastic cells do not match those of the host animal. Instead, neoplastic cells from dispersed locations in New York, Maine, and Prince Edward Island (PEI), Canada, all have nearly identical genotypes that differ from those of the host. These results indicate that the cancer is spreading between animals in the marine environment as a clonal transmissible cell derived from a single original clam. Our findings suggest that horizontal transmission of cancer cells is more widespread in nature than previously supposed.
[Mh] Termos MeSH primário: Mya/citologia
[Mh] Termos MeSH secundário: Animais
DNA Mitocondrial/genética
Leucemia/genética
Leucemia/patologia
Repetições de Microssatélites
Mya/genética
Retroelementos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (DNA, Mitochondrial); 0 (Retroelements)
[Em] Mês de entrada:1507
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150411
[St] Status:MEDLINE


  10 / 69 MEDLINE  
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[PMID]:25860599
[Au] Autor:Weiss RA; Fassati A
[Ad] Endereço:Wohl Virion Centre, Division of Infection and Immunity, University College London, Gower Street, London WC1E 6BT, UK. Electronic address: r.weiss@ucl.ac.uk.
[Ti] Título:The clammy grip of parasitic tumors.
[So] Source:Cell;161(2):191-2, 2015 Apr 09.
[Is] ISSN:1097-4172
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:An epidemic of leukemia among bivalve molluscs is spreading along the Atlantic coast of North America, with a serious population decline of soft-shelled clams. In this issue of Cell, Metzger et al. use forensic DNA markers to demonstrate that the leukemia cells have a clonal origin and appear to be transmitted through sea water.
[Mh] Termos MeSH primário: Mya/citologia
[Mh] Termos MeSH secundário: Animais
[Pt] Tipo de publicação:COMMENT; JOURNAL ARTICLE
[Em] Mês de entrada:1506
[Cu] Atualização por classe:150411
[Lr] Data última revisão:
150411
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150411
[St] Status:MEDLINE



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