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  1 / 164 MEDLINE  
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[PMID]:28465022
[Au] Autor:Wu D; Shi J; Peng K; Sheng J; Wang J; Wang B; Hong Y
[Ad] Endereço:School of Life Sciences, Nanchang University, Nanchang, China.
[Ti] Título:Structural characteristics of gonadal development and hermaphroditic phenomenon in freshwater pearl mussel, Sinohyriopisis schlegelii (Hyriopisis schlegelii).
[So] Source:Tissue Cell;49(3):440-446, 2017 Jun.
[Is] ISSN:1532-3072
[Cp] País de publicação:Scotland
[La] Idioma:eng
[Ab] Resumo:The period of gonads development was first studied from one to five years in the freshwater pearl mussel Hyriopisis schlegelii. It lasted for 36 months and was divided into three main stages: initiation of gonad formation, a stable growth phase, and a reproductive cell development phase. Each reproductive cycle consisted of five stages: proliferative stage (from late January to late February), growth stage (from late February to late March), maturation stage, spawning stage (from early April to late October) and recovery stage (from early November to late January). Interestingly, a hermaphroditic phenomenon was observed in this mussel for the first time, which appears during the development stage from 26 to 32 months. Male and female follicular tissues coexisted in hermaphrodite individuals with the male follicular tissue accounting for more than 90% of the whole gonad tissue. No hermaphroditic phenomenon was observed in matured gonad. We thus speculate that self-fertilization does not exist in H. schlegelii.
[Mh] Termos MeSH primário: Gônadas
Organismos Hermafroditas
Unionidae
[Mh] Termos MeSH secundário: Animais
Gônadas/citologia
Gônadas/fisiologia
Organismos Hermafroditas/citologia
Organismos Hermafroditas/fisiologia
Reprodução/fisiologia
Unionidae/citologia
Unionidae/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE


  2 / 164 MEDLINE  
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[PMID]:29261733
[Au] Autor:Liu X; Cao Y; Xue T; Wu R; Zhou Y; Zhou C; Zanatta DT; Ouyang S; Wu X
[Ad] Endereço:Poyang Lake Key Laboratory of Environment and Resource Utilization (Nanchang University), Ministry of Education, Nanchang, People's Republic of China.
[Ti] Título:Genetic structure and diversity of Nodularia douglasiae (Bivalvia: Unionida) from the middle and lower Yangtze River drainage.
[So] Source:PLoS One;12(12):e0189737, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The Yangtze River drainage in China is among the most species rich rivers for freshwater mussels (order Unionida) on Earth with at least 68 species known. The freshwater mussels of the Yangtze River face a variety of threats with indications that species are declining in abundance and area of occupancy. This study represents the first analyses of the genetic structure and diversity for the common and widespread freshwater mussel Nodularia douglasiae based on microsatellite DNA genotypes and mitochondrial DNA sequences. Phylogenetic analysis a fragment of the COI mitochondrial gene indicated that N. douglasiae collected from across the middle and lower Yangtze River drainage are monophyletic with N. douglasiae from Japan, Russia, and South Korea. The results of the analysis of both the mtDNA and microsatellite datasets indicated that the seven collection locations of N. douglasiae in the middle and lower Yangtze River drainage showed high genetic diversity, significant genetic differentiation and genetic structure, and stable population dynamics over time. Moreover, we found that the connections among tributaries rivers and lakes in the Yangtze River drainage were important in maintaining gene flow among locations that N. douglasiae inhabits. An understanding of the genetic structure and diversity of a widespread species like N. douglasiae could be used as a surrogate to better understand the populations of other freshwater mussel species that are more rare in the Yangtze River drainage. At the same time, these results could provide a basis for the protection of genetic diversity and management of unionid mussels diversity and other aquatic organisms in the system.
[Mh] Termos MeSH primário: Drenagem Sanitária
Variação Genética
Rios
Unionidae/genética
[Mh] Termos MeSH secundário: Animais
Sequência de Bases
Teorema de Bayes
China
DNA Mitocondrial/genética
Complexo IV da Cadeia de Transporte de Elétrons/genética
Fluxo Gênico
Genética Populacional
Genótipo
Geografia
Haplótipos/genética
Repetições de Microssatélites/genética
Filogenia
Análise de Componente Principal
Tamanho da Amostra
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Mitochondrial); EC 1.9.3.1 (Electron Transport Complex IV)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171221
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189737


  3 / 164 MEDLINE  
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[PMID]:28866087
[Au] Autor:Wang GL; Wang Q; Xu ZC; Wang YY; Li JL
[Ad] Endereço:Key Laboratory of Freshwater Aquatic Genetic Resources, Ministry of Agriculture, China; Shanghai Engineering Research Center of Aquaculture, China; National Demonstration Center for Experimental Fisheries Science Education (Shanghai Ocean University), China.
[Ti] Título:Identification, structural characterization and expression analysis of a novel carbonic anhydrase from freshwater mussel Hyriopsis cumingii.
[So] Source:Gene;636:78-86, 2017 Dec 15.
[Is] ISSN:1879-0038
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:In this study, an α-carbonic anhydrase (α-CA), HcCA3, from Hyriopsis cumingii was characterized. The full-length cDNA of HcCA3 was 1628bp, including a CA domain and an ORF of 1053bp which encoded 350 amino acids. Its predicted molecular weight was 39.69kDa and the pI was 5.92. qRT-PCR was used to determine the expression of the gene in various tissues at 0h, 3h, 6h, 12h, 24h, 48h, 96h, 7d, 14d, 21d, 28d and 35d after inserting the pearl nucleus. The results showed that the HcCA3 was highly expressed in the mantle, whereas its expression was low in other tissues. Expression in the posterior mantle pallial (pMP) was significantly higher than that in the anterior mantle pallial (aMP) and mantle center (MC). Expression in the aMP, pMP and MC was significantly higher in purple mussels compared with that in white mussels. At the same time, during the formation of pearls, expression in the aMP, pMP and pearl sac (PS) decreased and then increased; whereas expression in the MC increased and then decreased. In-situ hybridization showed that the HcCA3 was expressed in both inside and outside epidermal cells. In protein level, Western blot showed that HcCA3 was mainly expressed in the aMP, pMP and MC. Our results suggest that HcCA3 play a role in the formation of shell and pearl sac formation.
[Mh] Termos MeSH primário: Anidrases Carbônicas/genética
Anidrases Carbônicas/metabolismo
Unionidae/enzimologia
[Mh] Termos MeSH secundário: Animais
Anidrases Carbônicas/química
Anidrases Carbônicas/fisiologia
DNA Complementar/química
RNA Mensageiro/metabolismo
Análise de Sequência de Proteína
Distribuição Tecidual
Unionidae/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Complementary); 0 (RNA, Messenger); EC 4.2.1.1 (Carbonic Anhydrases)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171018
[Lr] Data última revisão:
171018
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170904
[St] Status:MEDLINE


  4 / 164 MEDLINE  
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[PMID]:28214599
[Au] Autor:Zhang HW; Huang Y; Man X; Wang Y; Hui KM; Yin SW; Zhang XW
[Ad] Endereço:College of Life Science, Henan Normal University, Xinxiang, Henan 453007, China; Division of Plant Sciences, University of Missouri, Columbia, MO 65201, USA.
[Ti] Título:HcToll3 was involved in anti-Vibrio defense in freshwater pearl mussel, Hyriopsis cumingii.
[So] Source:Fish Shellfish Immunol;63:189-195, 2017 Apr.
[Is] ISSN:1095-9947
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Toll-like receptors (TLRs) play an important role in the activation of innate immune response but their functions in bivalves remain largely unknown. In this study, we identified a TLR from the freshwater pearl mussel Hyriopsis cumingii (HcToll3) and investigated its functions in immunity. The full-length cDNA of HcToll3 is 3852 bp and includes an open reading frame (ORF) of 3228 bp that encodes a polypeptide of 1075 amino acids. The predicted HcToll3 protein shares similar structural characteristics with other known Toll family proteins. Quantitative real-time PCR analysis revealed that HcToll3 mRNA is broadly expressed in all of the examined tissues; its transcript level was significantly up-regulated by challenge with gram-negative bacteria Vibrio parahaemolyticus or lipopolysaccharide, but not gram-positive Staphylococcus aureus or peptidoglycan. RNA interference by siRNA results showed that HcToll3 regulated expression of whey acidic protein (HcWAP) and lysozymes (HcLyso1 and HcLyso2) in vivo and knockdown of HcToll3 suppressed the elimination of V. parahaemolyticus. These findings suggest that HcToll3 might be involved in anti-Vibrio defense in H. cumingii.
[Mh] Termos MeSH primário: Imunidade Inata
Receptor 3 Toll-Like/genética
Unionidae/genética
Unionidae/imunologia
Vibrio parahaemolyticus/fisiologia
[Mh] Termos MeSH secundário: Animais
Reação em Cadeia da Polimerase em Tempo Real
Análise de Sequência de DNA
Receptor 3 Toll-Like/metabolismo
Unionidae/microbiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Toll-Like Receptor 3)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170503
[Lr] Data última revisão:
170503
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170220
[St] Status:MEDLINE


  5 / 164 MEDLINE  
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[PMID]:28214598
[Au] Autor:Dai YJ; Hui KM; Zhang YH; Liu Y; Wang YQ; Zhao LJ; Lin L; Chai LQ; Wei S; Lan JF
[Ad] Endereço:State Key Laboratory of Cotton Biology, School of Life Sciences Henan University, Kaifeng 475004, China; Department of Aquatic Animal Medicine, Research Center for Marine Biology, College of Fisheries, Huazhong Agricultural University, Wuhan 430070, China.
[Ti] Título:Three STATs are involved in the regulation of the expression of antimicrobial peptides in the triangle sail mussel, Hyriopsis cumingii.
[So] Source:Fish Shellfish Immunol;63:181-188, 2017 Apr.
[Is] ISSN:1095-9947
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Janus kinase (Jak) and signal transducers and activators of transcription (STAT) signaling pathway is associated in antiviral and antibacterial immune response. Previous studies primarily investigated the function of STATs in mammals. For most invertebrates, only one STAT was found in each species, such as STAT92E was found in Drosophila melanogaster. The studies, which focus on the functional difference between various STATs in the same species of invertebrate, are limited. In the present study, three STATs (HcSTAT1, HcSTAT2 and HcSTAT3) were identified in triangle shell pearl mussel, Hyriopsis cumingii. Phylogenetic analysis showed that HcSTAT1 and HcSTAT3 were clustered with Homo sapiens STAT5, and HcSTAT2 was clustered with Pinctada fucata STAT and Crassostea gigas STAT6. All three STATs could be detected in all tested tissues (hemocytes, hepatopancreas, gill, mantle and foot), and were induced expression when challenged with Staphylococcus aureus or Aeromonas hydrophilia in hemocytes and hepatopancreas. HcSTAT1 regulated the expression of HcDef, HcWAP, HcThe and HcTNF. The expression of HcWAP and HcTNF was down-regulated in HcSTAT2-RNAi mussel. And HcSTAT3 affected the expression of HcTNF. The study is the first report of different functions in antibacterial immune responses between STATs in mollusks.
[Mh] Termos MeSH primário: Aeromonas hydrophila/fisiologia
Regulação da Expressão Gênica/imunologia
Imunidade Inata/genética
Fatores de Transcrição STAT/metabolismo
Staphylococcus aureus/fisiologia
Unionidae/genética
Unionidae/imunologia
[Mh] Termos MeSH secundário: Animais
Especificidade de Órgãos
Filogenia
Fatores de Transcrição STAT/genética
Análise de Sequência de DNA
Unionidae/microbiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (STAT Transcription Factors)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170503
[Lr] Data última revisão:
170503
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170220
[St] Status:MEDLINE


  6 / 164 MEDLINE  
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[PMID]:28123096
[Au] Autor:Marie B; Arivalagan J; Mathéron L; Bolbach G; Berland S; Marie A; Marin F
[Ad] Endereço:UMR 7245 CNRS/MNHN Molécules de Communications et Adaptations des Micro-organismes, Muséum National d'Histoire Naturelle, Sorbonne Universités, Paris, France bmarie@mnhn.fr.
[Ti] Título:Deep conservation of bivalve nacre proteins highlighted by shell matrix proteomics of the Unionoida Elliptio complanata and Villosa lienosa.
[So] Source:J R Soc Interface;14(126), 2017 Jan.
[Is] ISSN:1742-5662
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The formation of the molluscan shell nacre is regulated to a large extent by a matrix of extracellular macromolecules that are secreted by the shell-forming tissue, the mantle. This so-called 'calcifying matrix' is a complex mixture of proteins, glycoproteins and polysaccharides that is assembled and occluded within the mineral phase during the calcification process. Better molecular-level characterization of the substances that regulate nacre formation is still required. Notable advances in expressed tag sequencing of freshwater mussels, such as Elliptio complanata and Villosa lienosa, provide a pre-requisite to further characterize bivalve nacre proteins by a proteomic approach. In this study, we have identified a total of 48 different proteins from the insoluble matrices of the nacre, 31 of which are common to both E. complanata and V. lienosa A few of these proteins, such as PIF, MSI60, CA, shematrin-like, Kunitz-like, LamG, chitin-binding-containing proteins, together with A-, D-, G-, M- and Q-rich proteins, appear to be analogues, if not true homologues, of proteins previously described from the pearl oyster or the edible mussel nacre matrices, thus forming a remarkable list of deeply conserved nacre proteins. This work constitutes a comprehensive nacre proteomic study of non-pteriomorphid bivalves that has enabled us to describe the molecular basis of a deeply conserved biomineralization toolkit among nacreous shell-bearing bivalves, with regard to proteins associated with other shell microstructures, with those of other mollusc classes (gastropods, cephalopods) and, finally, with other lophotrochozoans (brachiopods).
[Mh] Termos MeSH primário: Calcificação Fisiológica/fisiologia
Evolução Molecular
Proteínas da Matriz Extracelular
Nácar
Unionidae
[Mh] Termos MeSH secundário: Exoesqueleto/química
Exoesqueleto/metabolismo
Animais
Proteínas da Matriz Extracelular/química
Proteínas da Matriz Extracelular/classificação
Proteínas da Matriz Extracelular/genética
Proteínas da Matriz Extracelular/metabolismo
Nácar/química
Nácar/genética
Nácar/metabolismo
Proteômica
Unionidae/química
Unionidae/classificação
Unionidae/genética
Unionidae/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Extracellular Matrix Proteins); 0 (Nacre)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170127
[St] Status:MEDLINE


  7 / 164 MEDLINE  
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[PMID]:28068380
[Au] Autor:Wen HB; Cao ZM; Hua D; Xu P; Ma XY; Jin W; Yuan XH; Gu RB
[Ad] Endereço:Wuxi Fishery College, Nanjing Agriculture University, Jiangsu, China.
[Ti] Título:The Complete Maternally and Paternally Inherited Mitochondrial Genomes of a Freshwater Mussel Potamilus alatus (Bivalvia: Unionidae).
[So] Source:PLoS One;12(1):e0169749, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Doubly uniparental inheritance (DUI) of mitochondrial DNA, found only in some bivalve families and characterized by the existence of gender-associated mtDNA lineages that are inherited through males (M-type) or females (F-type), is one of the very few exceptions to the general rule of strict maternal mtDNA inheritance in animals. M-type sequences are often undetected and hence still underrepresented in the GenBank, which hinders the progress of the understanding of the DUI phenomenon. We have sequenced and analyzed the complete M and F mitogenomes of a freshwater mussel, Potamilus alatus. The M-type was 493 bp longer (M = 16 560, F = 16 067 bp). Gene contents, order and the distribution of genes between L and H strands were typical for unionid mussels. Candidates for the two ORFan genes (forf and morf) were found in respective mitogenomes. Both mitogenomes had a very similar A+T bias: F = 61% and M = 62.2%. The M mitogenome-specific cox2 extension (144 bp) is much shorter than in other sequenced unionid mitogenomes (531-576 bp), which might be characteristic for the Potamilus genus. The overall topology of the phylogenetic tree is in very good agreement with the currently accepted phylogenetic relationships within the Unionidae: both studied sequences were placed within the Ambleminae subfamily clusters in the corresponding M and F clades.
[Mh] Termos MeSH primário: Genoma Mitocondrial
Herança Materna
Herança Paterna
Unionidae/genética
[Mh] Termos MeSH secundário: Animais
Composição de Bases
Feminino
Ordem dos Genes
Tamanho do Genoma
Genômica
Masculino
Fases de Leitura Aberta
Filogenia
Análise de Sequência de DNA
Unionidae/classificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170810
[Lr] Data última revisão:
170810
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170110
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0169749


  8 / 164 MEDLINE  
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[PMID]:27979780
[Au] Autor:Hu B; Wen C; Zhang M; Jian S; Yang G
[Ad] Endereço:School of Life Sciences, Nanchang University, Nanchang 330031, China.
[Ti] Título:Identification and characterization of two LBP/BPI genes involved in innate immunity from Hyriopsis cumingii.
[So] Source:Fish Shellfish Immunol;60:436-446, 2017 Jan.
[Is] ISSN:1095-9947
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Lipopolysaccharide-binding protein and bactericidal permeability-increasing protein (LBP/BPI) play crucial role in modulating cellular signals in response to Gram-negative bacteria infection. In the present study, two isoforms of LBP/BPI genes, designated as HcLBP/BPI1 and HcLBP/BPI2, respectively, were cloned from the mussel Hyriopsis cumingii by RACE approach. The full-length cDNA sequences of HcLBP/BPI1 and HcLBP/BPI2 were 1887 and 2227 bp and encoded two secreted proteins of 501 and 518 amino acid residues, respectively. The deduced amino acid of HcLBP/BPI1 and HcLBP/BPI2 contained several conserved domains, such as signal peptide, two BPI/LBP and one central domain. Phylogentic analysis further supported that HcLBP/BPI1 and HcLBP/BPI2 belonged to new members of invertebrate LBP/BPI family. The mRNA transcripts of HcLBP/BPI1 and HcLBP/BPI2 were ubiquitously expressed in all examined tissues, and the expression level of HcLBP/BPI1 was higher than that of HcLBP/BPI2. The mRNA expression of HcLBP/BPI1 in hepatopancreas and hemocytes was significantly up-regulate after Aeromonas hydrophila and LPS challenge, and HcLBP/BPI2 in hepatopancreas was only up-regulated at 6 and 12 h after LPS challenge and at 12 h after A. hydrophila challenge. In addition, the recombinant HcLBP/BPIs displayed antibacterial activity against Gram-negative bacteria, and the antibacterial index of HcLBP/BPI1 was higher than that of HcLBP/BPI2. These results indicated that HcLBP/BPI1 and HcLBP/BPI2 probably played distinct roles in bacterial mediating immune response in Mollusca.
[Mh] Termos MeSH primário: Proteínas da Fase Aguda/genética
Peptídeos Catiônicos Antimicrobianos/genética
Proteínas Sanguíneas/genética
Proteínas de Transporte/genética
Imunidade Inata/genética
Glicoproteínas de Membrana/genética
Unionidae/genética
Unionidae/imunologia
[Mh] Termos MeSH secundário: Proteínas da Fase Aguda/imunologia
Aeromonas hydrophila/fisiologia
Sequência de Aminoácidos
Animais
Peptídeos Catiônicos Antimicrobianos/imunologia
Sequência de Bases
Proteínas Sanguíneas/imunologia
Proteínas de Transporte/imunologia
Clonagem Molecular
DNA Complementar/genética
DNA Complementar/metabolismo
Regulação da Expressão Gênica/efeitos dos fármacos
Regulação da Expressão Gênica/genética
Lipopolissacarídeos/farmacologia
Glicoproteínas de Membrana/imunologia
Filogenia
Isoformas de Proteínas/genética
RNA Mensageiro/genética
RNA Mensageiro/metabolismo
Alinhamento de Sequência
Unionidae/classificação
Unionidae/microbiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acute-Phase Proteins); 0 (Antimicrobial Cationic Peptides); 0 (Blood Proteins); 0 (Carrier Proteins); 0 (DNA, Complementary); 0 (Lipopolysaccharides); 0 (Membrane Glycoproteins); 0 (Protein Isoforms); 0 (RNA, Messenger); 0 (bactericidal permeability increasing protein); 0 (lipopolysaccharide-binding protein)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170327
[Lr] Data última revisão:
170327
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161217
[St] Status:MEDLINE


  9 / 164 MEDLINE  
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[PMID]:27881036
[Au] Autor:Shi J; Wang D; Zhou Y; Gu Y; Wu D; Wang J; Hong Y
[Ad] Endereço:a School of Life Sciences , Nanchang University , Nanchang , China.
[Ti] Título:Comparative proteomics analysis of spermary and ovary in Hyriopsis schlegelii.
[So] Source:Biosci Biotechnol Biochem;81(3):491-499, 2017 Mar.
[Is] ISSN:1347-6947
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:We provide the first large-scale quantitative proteomics analysis in Hyriopsis schlegelii. To investigate the proteins expressed in the gonads, a quantitative proteomics approach has been utilized to analyze differentially expressed proteins between the spermary and ovary. In this study, we identified and quantified 2416 proteins in the gonads of Hyriopsis schlegelii. Of these, 559 proteins showed significantly different expression between the spermary and ovary. Some specific proteins expressed in either the spermary or ovary were identified in Hyriopsis schlegelii. In addition, a series of proteins related to gametogenesis were also identified. Compared with previous reports, many proteins in Hyriopsis schlegelii identified here have different expression patterns between the spermary and ovary. The special hermaphroditism in Hyriopsis schlegelii may contribute to these inconsistent results. The provided proteomics data could be considered as a starting point for subsequent studies focusing on the proteins involved in sexual gland development and maturity.
[Mh] Termos MeSH primário: Proteoma/metabolismo
Unionidae/metabolismo
[Mh] Termos MeSH secundário: Animais
Feminino
Ontologia Genética
Genitália Masculina/crescimento & desenvolvimento
Genitália Masculina/metabolismo
Masculino
Ovário/crescimento & desenvolvimento
Ovário/metabolismo
Proteoma/genética
Proteômica/métodos
Unionidae/crescimento & desenvolvimento
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Proteome)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170306
[Lr] Data última revisão:
170306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161125
[St] Status:MEDLINE
[do] DOI:10.1080/09168451.2016.1259553


  10 / 164 MEDLINE  
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[PMID]:27859528
[Au] Autor:Gilroy ÈAM; Gillis PL; King LE; Bendo NA; Salerno J; Giacomin M; de Solla SR
[Ad] Endereço:Green House Science, Burlington, Ontario, Canada.
[Ti] Título:The effects of pharmaceuticals on a unionid mussel (Lampsilis siliquoidea): An examination of acute and chronic endpoints of toxicity across life stages.
[So] Source:Environ Toxicol Chem;36(6):1572-1583, 2017 Jun.
[Is] ISSN:1552-8618
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The toxicity and bioconcentration of 3 pharmaceuticals (amitriptyline, iopamidol, and sertraline) were examined using multiple life stages (larval, juvenile, and adult) of the unionid mussel Lampsilis siliquoidea. The endpoints examined varied with life stage but included survival, behavior (algal clearance rate, filtering frequency), and oxidative stress. Iopamidol was not toxic at concentrations up to 101 mg/L. Sertraline was the most toxic chemical (50% lethal concentrations [LC50] and effect concentrations [EC50] = 0.02-0.04 mg/L), but exposure did not induce oxidative stress. Glochidia and juveniles were more sensitive than adult mussels. Algal clearance rate in juvenile mussels was the most sensitive endpoint assessed, similar to or lower than the LC50 values for glochidia. However, the compounds examined were not toxic at concentrations detected in the environment. The relative bioconcentration factors were sertraline > amitriptyline > iopamidol. These results suggest that glochidia toxicity could be a screening tool for rapidly assessing the toxicity of chemicals of concern to freshwater mussels. Environ Toxicol Chem 2017;36:1572-1583. © 2016 SETAC.
[Mh] Termos MeSH primário: Amitriptilina/toxicidade
Iopamidol/toxicidade
Sertralina/toxicidade
Unionidae/efeitos dos fármacos
Poluentes Químicos da Água/toxicidade
[Mh] Termos MeSH secundário: Amitriptilina/administração & dosagem
Animais
Antidepressivos/administração & dosagem
Antidepressivos/toxicidade
Meios de Contraste/administração & dosagem
Meios de Contraste/toxicidade
Esquema de Medicação
Água Doce/química
Iopamidol/administração & dosagem
Larva/efeitos dos fármacos
Sertralina/administração & dosagem
Poluentes Químicos da Água/administração & dosagem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antidepressive Agents); 0 (Contrast Media); 0 (Water Pollutants, Chemical); 1806D8D52K (Amitriptyline); JR13W81H44 (Iopamidol); QUC7NX6WMB (Sertraline)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170918
[Lr] Data última revisão:
170918
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161119
[St] Status:MEDLINE
[do] DOI:10.1002/etc.3683



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