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[PMID]:29331278
[Au] Autor:Sobhy MMK; Mahmoud SS; El-Sayed SH; Rizk EMA; Raafat A; Negm MSI
[Ad] Endereço:Medical Parasitology Department, Kasr Al-Ainy School of Medicine, Cairo University, Egypt.
[Ti] Título:Impact of treatment with a Protein Tyrosine Kinase Inhibitor (Genistein) on acute and chronic experimental Schistosoma mansoni infection.
[So] Source:Exp Parasitol;185:115-123, 2018 Feb.
[Is] ISSN:1090-2449
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Schistosomiasis mansoni is considered one of the most common fibrotic diseases resulting from inflammation and deposition of fibrous tissue around parasitic eggs trapped in the liver, causing morbidity and mortality. Chemotherapy against schistosomiasis is largely dependent on Praziquantel (PZQ). Yet, the huge administration of it in endemic areas and its incompetence towards the immature stages have raised serious alarms against the development of drug resistance. Few drugs are directed to reverse schistosomal liver fibrosis, particularly at the chronic and advanced stages of the disease. Recently, protein tyrosine kinase (PTK) inhibitors have been identified as potent anti-schistosomal and anti-fibrotic drugs against schistosomes, that may suppress and reverse Schistosoma mansoni (S. mansoni) induced liver fibrosis. The present study was designed to assess the anti-schistosomal and antifibrotic activity of Genistein, a PTK inhibitor, in comparison to PZQ, on both acute and chronic S. mansoni-infected mice using different parasitological, histopathological and immunohistochemical studies. Genistein showed a significant reduction (P < .05) in total worm burden, tissue egg load, mean hepatic granulomas diameter and numbers, percentage of collagen and expression of transforming growth factor-beta 1 (TGF-ß 1) in the examined hepatocytes with elevation in percentage of degenerated ova, in comparison to the control groups, in both acute and chronic stages of infection. The best results were obtained when Genistein was combined with PZQ. Therefore, it was concluded that Genistein showed a promising anti-schistosomal and anti-fibrotic properties which could make it one of the new potential targets in chemotherapy against schistosomiasis.
[Mh] Termos MeSH primário: Genisteína/uso terapêutico
Inibidores de Proteínas Quinases/uso terapêutico
Proteínas Tirosina Quinases/antagonistas & inibidores
Esquistossomose mansoni/tratamento farmacológico
[Mh] Termos MeSH secundário: Doença Aguda
Animais
Anti-Helmínticos/farmacologia
Anti-Helmínticos/uso terapêutico
Biomphalaria
Doença Crônica
Colágeno/análise
Feminino
Genisteína/farmacologia
Granuloma/tratamento farmacológico
Granuloma/patologia
Processamento de Imagem Assistida por Computador
Imuno-Histoquímica/veterinária
Fígado/química
Fígado/parasitologia
Fígado/patologia
Cirrose Hepática/tratamento farmacológico
Cirrose Hepática/parasitologia
Cirrose Hepática/patologia
Masculino
Camundongos
Praziquantel/farmacologia
Praziquantel/uso terapêutico
Inibidores de Proteínas Quinases/farmacologia
Schistosoma mansoni/efeitos dos fármacos
Schistosoma mansoni/patogenicidade
Esquistossomose mansoni/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anthelmintics); 0 (Protein Kinase Inhibitors); 6490C9U457 (Praziquantel); 9007-34-5 (Collagen); DH2M523P0H (Genistein); EC 2.7.10.1 (Protein-Tyrosine Kinases)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180115
[St] Status:MEDLINE


  2 / 2449 MEDLINE  
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[PMID]:28832617
[Au] Autor:Omobhude ME; Morenikeji OA; Oyeyemi OT
[Ad] Endereço:Department of Zoology, University of Ibadan, Ibadan, Nigeria.
[Ti] Título:Molluscicidal activities of curcumin-nisin polylactic acid nanoparticle on Biomphalaria pfeifferi.
[So] Source:PLoS Negl Trop Dis;11(8):e0005855, 2017 Aug.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Snail intermediate host control is a widely canvassed strategy for schistosomiasis control in endemic countries. While there have been increasing studies on the search for potent molluscicides in the past years, the use of nanoparticulate agents as molluscicides is yet to gain wide attention. The aim of this study was to assess the molluscicidal potential of curcumin-nisin poly lactic acid (PLA) entrapped nanoparticle (CurNisNp) against Biomphalaria pfeifferi, a snail intermediate host for Schistosoma mansoni. METHODOLOGY/PRINCIPAL FINDINGS: CurNisNp formulated by double emulsion method was tested against the young adults, < 1 week, 1-2-week old juveniles, 1 day (blastula) and 7 day-old (hippo-stage) egg masses of B. pfeifferi. Mortality in the different stages was determined after 96-h of exposure at varying concentrations (350, 175, 87.5, 43.75 and 21.88 ppm). The sub-lethal effects of CurNisNp on the hatchability of the 7-day-old egg masses and egg laying capacity of the young adult snails were determined. The CurNisNp diameter, polydispersity index (PDI), zeta potential and drug entrapment efficiency were 284.0 ± 17.9 nm, 0.166 ± 0.03, -16.6 ± 2.45 mV and 35.0% respectively. The < 1 week old juveniles and the 1-day-old egg stage (blastula) of B. pfeifferi with LC50 277.9 ppm and 4279.5 ppm were the most susceptible and resistant stages to the drug respectively. CurNisNp was also observed to cause significant reductions (P<0.05) in egg hatchability and egg laying capacity with strong negative correlation between egg laying capacity and concentration (r = -0.928; P<0.05). CONCLUSION/SIGNIFICANCE: This study showed that CurNisNp has molluscicidal activities on different developmental stages of B. pfeifferi. It is therefore recommended that the formulation be more optimised to give a nanoparticle with a narrow range monodispersed PDI for better drug distribution and eventual greater molluscicidal activities.
[Mh] Termos MeSH primário: Biomphalaria/efeitos dos fármacos
Curcumina/farmacologia
Moluscocidas/farmacologia
Nanopartículas
Nisina/farmacologia
Poliésteres/farmacologia
[Mh] Termos MeSH secundário: Animais
Emulsões
Nisina/efeitos adversos
Óvulo/efeitos dos fármacos
Extratos Vegetais/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Emulsions); 0 (Molluscacides); 0 (Plant Extracts); 0 (Polyesters); 0 (nisin A); 1414-45-5 (Nisin); 459TN2L5F5 (poly(lactide)); IT942ZTH98 (Curcumin)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170918
[Lr] Data última revisão:
170918
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170824
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0005855


  3 / 2449 MEDLINE  
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[PMID]:28753630
[Au] Autor:Augusto RC; Tetreau G; Chan P; Walet-Balieu ML; Mello-Silva CC; Santos CP; Grunau C
[Ad] Endereço:Laboratório de Avaliação e Promoção da Saúde Ambiental, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Brasil.
[Ti] Título:Double impact: natural molluscicide for schistosomiasis vector control also impedes development of Schistosoma mansoni cercariae into adult parasites.
[So] Source:PLoS Negl Trop Dis;11(7):e0005789, 2017 Jul.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Schistosomiasis has been reported in 78 endemic countries and affects 240 million people worldwide. The digenetic parasite Schistosoma mansoni needs fresh water to compete its life cycle. There, it is susceptible to soluble compounds that can affect directly and/or indirectly the parasite's biology. The cercariae stage is one of the key points in which the parasite is vulnerable to different soluble compounds that can significantly alter the parasite's life cycle. Molluscicides are recommended by the World Health Organization for the control of schistosomiasis transmission and Euphorbia milii latex is effective against snails intermediate hosts. METHODOLOGY/PRINCIPAL FINDINGS: We used parasitological tools and electron microscopy to verify the effects of cercariae exposure to natural molluscicide (Euphorbia milii latex) on morphology, physiology and fitness of adult parasite worms. In order to generate insights into key metabolic pathways that lead to the observed phenotypes we used comparative transcriptomics and proteomics. CONCLUSIONS/SIGNIFICANCE: We describe here that the effect of latex on the adult is not due to direct toxicity but it triggers an early change in developmental trajectory and perturbs cell memory, mobility, energy metabolism and other key pathways. We conclude that latex has not only an effect on the vector but applies also long lasting schistosomastatic action. We believe that these results are of interest not only to parasitologists since it shows that natural compounds, presumably without side effects, can have an impact that occurred unexpectedly on developmental processes. Such collateral damage is in this case positive, since it impacts the true target of the treatment campaign. This type of treatment could also provide a rational for the control of other pests. Our results will contribute to enforce the use of E. milii latex in Brazil and other endemic countries as cheap alternative or complement to mass drug treatment with Praziquantel, the only available drug to cure the patients (without preventing re-infection).
[Mh] Termos MeSH primário: Cercárias/crescimento & desenvolvimento
Látex/administração & dosagem
Moluscocidas/administração & dosagem
Schistosoma mansoni/efeitos dos fármacos
Schistosoma mansoni/ultraestrutura
[Mh] Termos MeSH secundário: Animais
Biomphalaria/parasitologia
Brasil
Cercárias/efeitos dos fármacos
Feminino
Modelos Lineares
Fígado/patologia
Masculino
Camundongos
Microscopia Eletrônica
Carga Parasitária
Extratos Vegetais/administração & dosagem
Esquistossomose mansoni/parasitologia
Esquistossomose mansoni/prevenção & controle
Análise de Sequência de RNA
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Latex); 0 (Molluscacides); 0 (Plant Extracts)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170729
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0005789


  4 / 2449 MEDLINE  
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Caldeira, Roberta Lima
Coelho, Paulo Marcos Zech
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[PMID]:28719649
[Au] Autor:Queiroz FR; Silva LM; Jeremias WJ; Babá ÉH; Caldeira RL; Coelho PMZ; Gomes MS
[Ad] Endereço:Grupo de Pesquisa em Biologia do Schistosoma mansoni e sua Interação com o Hospedeiro, Centro de Pesquisas René Rachou, Fundação Oswaldo Cruz, Belo Horizonte, Minas Gerais, Brasil.
[Ti] Título:Differential expression of small RNA pathway genes associated with the Biomphalaria glabrata/Schistosoma mansoni interaction.
[So] Source:PLoS One;12(7):e0181483, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The World Health Organization (WHO) estimates that approximately 240 million people in 78 countries require treatment for schistosomiasis, an endemic disease caused by trematodes of the genus Schistosoma. In Brazil, Schistosoma mansoni is the only species representative of the genus whose passage through an invertebrate host, snails of the genus Biomphalaria, is obligatory before infecting a mammalian host, including humans. The availability of the genome and transcriptome of B. glabrata makes studying the regulation of gene expression, particularly the regulation of miRNA and piRNA processing pathway genes, possible. This might assist in better understanding the biology of B. glabrata as well as its relationship to the parasite S. mansoni. Some aspects of this interaction are still poorly explored, including the participation of non-coding small RNAs, such as miRNAs and piRNAs, with lengths varying from 18 to 30 nucleotides in mature form, which are potent regulators of gene expression. Using bioinformatics tools and quantitative PCR, we characterized and validated the miRNA and piRNA processing pathway genes in B. glabrata. In silico analyses showed that genes involved in miRNA and piRNA pathways were highly conserved in protein domain distribution, catalytic site residue conservation and phylogenetic analysis. Our study showed differential expression of putative Argonaute, Drosha, Piwi, Exportin-5 and Tudor genes at different snail developmental stages and during infection with S. mansoni, suggesting that the machinery is required for miRNA and piRNA processing in B. glabrata at all stages. These data suggested that the silencing pathway mediated by miRNAs and piRNAs can interfere in snail biology throughout the life cycle of the snail, thereby influencing the B. glabrata/S. mansoni interaction. Further studies are needed to confirm the participation of the small RNA processing pathway proteins in the parasite/host relationship, mainly the effective participation of small RNAs in regulating their target genes.
[Mh] Termos MeSH primário: Biomphalaria/genética
MicroRNAs/genética
Schistosoma mansoni/genética
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Animais
Sequência de Bases
Perfilação da Expressão Gênica
Filogenia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (MicroRNAs)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170925
[Lr] Data última revisão:
170925
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170719
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0181483


  5 / 2449 MEDLINE  
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[PMID]:28604263
[Au] Autor:de Núñez MO
[Ad] Endereço:Departamento de Biodiversidad y Biología Experimental, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pabellón II, 1428 Buenos Aires, Argentina.
[Ti] Título:Redescription of Austrodiplostomum compactum (Trematoda: Diplostomidae) from its Type Host and Locality in Venezuela, and of Austrodiplostomum mordax from Argentina.
[So] Source:J Parasitol;103(5):497-505, 2017 Oct.
[Is] ISSN:1937-2345
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Austrodiplostomum compactum from Nannopterum brasilianus, and its metacercaria from Geophagus sp. and Oreochromis mossambicus captured (1979) at its type locality, Valencia Lake, Venezuela, by the author, are redescribed. The adult is characterized by its large body size, and an oral sucker smaller than the pharynx. The metacercaria has a similar body size as the adult, and the small genital primordia occupy 4.1-7.3% of body length. Experimental infections in chickens with metacercariae of Diplostomulum mordax from brains of Odonthestes bonariensis, captured (2015) at Dique Paso de las Piedras, near Bahia Blanca City, Buenos Aires Province, Argentina, resulted in 10 adults 5 days postexposure. These adults correspond to Austrodiplostomum mordax as described from N. brasilianus at Lacombe Lagoon, Buenos Aires Province, and differ from A. compactum in their smaller body size, and an oral sucker larger than the pharynx. The metacercaria has a similar body size as the adult and differs mainly in that the larger genital primordia occupy 11.6-13.8% of body length. The status of earlier published Austrodiplostomum species in the American continent is discussed in view of available morphological and molecular data. A lectotype of A. mordax is here designated, and Austrodiplostomum ostrowskiae is considered as a new synonym of A. compactum.
[Mh] Termos MeSH primário: Ciclídeos/parasitologia
Doenças dos Peixes/parasitologia
Tilápia/parasitologia
Trematódeos/classificação
Infecções por Trematódeos/veterinária
[Mh] Termos MeSH secundário: Animais
Argentina
Biomphalaria/parasitologia
Doenças das Aves/parasitologia
Aves
Encéfalo/parasitologia
Galinhas/parasitologia
Olho/parasitologia
Intestinos/parasitologia
Lagos
Trematódeos/anatomia & histologia
Trematódeos/isolamento & purificação
Infecções por Trematódeos/parasitologia
Venezuela
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171025
[Lr] Data última revisão:
171025
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170613
[St] Status:MEDLINE
[do] DOI:10.1645/16-128


  6 / 2449 MEDLINE  
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[PMID]:28520808
[Au] Autor:Wu XJ; Dinguirard N; Sabat G; Lui HD; Gonzalez L; Gehring M; Bickham-Wright U; Yoshino TP
[Ad] Endereço:Department of Pathobiological Sciences, University of Wisconsin, Madison, WI, United States of America.
[Ti] Título:Proteomic analysis of Biomphalaria glabrata plasma proteins with binding affinity to those expressed by early developing larval Schistosoma mansoni.
[So] Source:PLoS Pathog;13(5):e1006081, 2017 May.
[Is] ISSN:1553-7374
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Interactions between early developing Schistosoma mansoni larval stages and the hemolymph of its snail intermediate host represent the first molecular encounter with the snail's immune system. To gain a more comprehensive understanding of this early parasite-host interaction, biotinylated sporocyst tegumental membrane (Mem) proteins and larval transformation proteins (LTP) were affixed to streptavidin-agarose beads and used as affinity matrices to enrich for larval-reactive plasma proteins from susceptible (NMRI) and resistant (BS-90) strains of the snail Biomphalaria glabrata. Nano-LC/MS-MS proteomic analyses of isolated plasma proteins revealed a diverse array of 94 immune-and nonimmune-related plasma proteins. Included among the immune-related subset were pattern recognition receptors (lectins, LPS-binding protein, thioester-containing proteins-TEPs), stress proteins (HSP60 and 70), adhesion proteins (dermatopontins), metalloproteases (A Disintegrin And Metalloproteinase (ADAM), ADAM-related Zn proteinases), cytotoxins (biomphalysin) and a Ca2+-binding protein (neo-calmodulin). Variable immunoglobulin and lectin domain (VIgL) gene family members, including fibrinogen-related proteins (FREPs), galectin-related proteins (GREPs) and C-type lectin-related proteins (CREPs), were the most prevalent of larval-reactive immune lectins present in plasma. FREPs were highly represented, although only a subset of FREP subfamilies (FREP 2, 3 and 12) were identified, suggesting potential selectivity in the repertoire of plasma lectins recognizing larval glycoconjugates. Other larval-binding FREP-like and CREP-like proteins possessing a C-terminal fibrinogen-related domain (FReD) or C-type lectin binding domain, respectively, and an Ig-fold domain also were identified as predicted proteins from the B. glabrata genome, although incomplete sequence data precluded their placement into specific FREP/CREP subfamilies. Similarly, a group of FReD-containing proteins (angiopoeitin-4, ficolin-2) that lacked N-terminal Ig-fold(s) were identified as a distinct group of FREP-like proteins, separate from the VIgL lectin family. Finally, differential appearance of GREPs in BS-90 plasma eluates, and others proteins exclusively found in eluates of the NMRI strain, suggested snail strain differences in the expression of select larval-reactive immune proteins. This hypothesis was supported by the finding that differential gene expression of the GREP in BS-90 and ADAM in NMRI snail strains generally correlated with their patterns of protein expression. In summary, this study is the first to provide a global comparative proteomic analysis of constitutively expressed plasma proteins from susceptible and resistant B. glabrata strains capable of binding early-expressed larval S. mansoni proteins. Identified proteins, especially those exhibiting differential expression, may play a role in determining immune compatibility in this snail host-parasite system. A complete listing of raw peptide data are available via ProteomeXchange using identifier PXD004942.
[Mh] Termos MeSH primário: Biomphalaria/metabolismo
Proteínas Sanguíneas/metabolismo
Proteínas de Helminto/metabolismo
Interações Hospedeiro-Parasita
Proteômica
Schistosoma mansoni/fisiologia
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Animais
Proteínas de Bactérias
Biomphalaria/imunologia
Biomphalaria/parasitologia
Hemolinfa/metabolismo
Larva
Mapeamento de Interação de Proteínas
Schistosoma mansoni/imunologia
Schistosoma mansoni/metabolismo
Sefarose/análogos & derivados
Alinhamento de Sequência
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bacterial Proteins); 0 (Blood Proteins); 0 (Helminth Proteins); 0 (streptavidin-agarose); 9012-36-6 (Sepharose)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171003
[Lr] Data última revisão:
171003
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170519
[St] Status:MEDLINE
[do] DOI:10.1371/journal.ppat.1006081


  7 / 2449 MEDLINE  
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[PMID]:28510608
[Au] Autor:Geyer KK; Niazi UH; Duval D; Cosseau C; Tomlinson C; Chalmers IW; Swain MT; Cutress DJ; Bickham-Wright U; Munshi SE; Grunau C; Yoshino TP; Hoffmann KF
[Ad] Endereço:Institute of Biological, Environmental and Rural Sciences, Aberystwyth University, Penglais Campus, Aberystwyth, United Kingodm.
[Ti] Título:The Biomphalaria glabrata DNA methylation machinery displays spatial tissue expression, is differentially active in distinct snail populations and is modulated by interactions with Schistosoma mansoni.
[So] Source:PLoS Negl Trop Dis;11(5):e0005246, 2017 May.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The debilitating human disease schistosomiasis is caused by infection with schistosome parasites that maintain a complex lifecycle alternating between definitive (human) and intermediate (snail) hosts. While much is known about how the definitive host responds to schistosome infection, there is comparably less information available describing the snail's response to infection. METHODOLOGY/PRINCIPLE FINDINGS: Here, using information recently revealed by sequencing of the Biomphalaria glabrata intermediate host genome, we provide evidence that the predicted core snail DNA methylation machinery components are associated with both intra-species reproduction processes and inter-species interactions. Firstly, methyl-CpG binding domain protein (Bgmbd2/3) and DNA methyltransferase 1 (Bgdnmt1) genes are transcriptionally enriched in gonadal compared to somatic tissues with 5-azacytidine (5-AzaC) treatment significantly inhibiting oviposition. Secondly, elevated levels of 5-methyl cytosine (5mC), DNA methyltransferase activity and 5mC binding in pigmented hybrid- compared to inbred (NMRI)- B. glabrata populations indicate a role for the snail's DNA methylation machinery in maintaining hybrid vigour or heterosis. Thirdly, locus-specific detection of 5mC by bisulfite (BS)-PCR revealed 5mC within an exonic region of a housekeeping protein-coding gene (Bg14-3-3), supporting previous in silico predictions and whole genome BS-Seq analysis of this species' genome. Finally, we provide preliminary evidence for parasite-mediated host epigenetic reprogramming in the schistosome/snail system, as demonstrated by the increase in Bgdnmt1 and Bgmbd2/3 transcript abundance following Bge (B. glabrata embryonic cell line) exposure to parasite larval transformation products (LTP). CONCLUSIONS/SIGNIFICANCE: The presence of a functional DNA methylation machinery in B. glabrata as well as the modulation of these gene products in response to schistosome products, suggests a vital role for DNA methylation during snail development/oviposition and parasite interactions. Further deciphering the role of this epigenetic process during Biomphalaria/Schistosoma co-evolutionary biology may reveal key factors associated with disease transmission and, moreover, enable the discovery of novel lifecycle intervention strategies.
[Mh] Termos MeSH primário: Biomphalaria/genética
Biomphalaria/parasitologia
Metilação de DNA
Interações Hospedeiro-Parasita
Schistosoma mansoni/fisiologia
[Mh] Termos MeSH secundário: Animais
Azacitidina/farmacologia
DNA (Citosina-5-)-Metiltransferase 1
DNA (Citosina-5-)-Metiltransferases/genética
Proteínas de Ligação a DNA/genética
Inibidores Enzimáticos/farmacologia
Epigênese Genética
Perfilação da Expressão Gênica
Seres Humanos
Oviposição/efeitos dos fármacos
Filogenia
Esquistossomose mansoni/parasitologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA-Binding Proteins); 0 (Enzyme Inhibitors); EC 2.1.1.37 (DNA (Cytosine-5-)-Methyltransferase 1); EC 2.1.1.37 (DNA (Cytosine-5-)-Methyltransferases); M801H13NRU (Azacitidine)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170517
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0005246


  8 / 2449 MEDLINE  
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[PMID]:28363777
[Au] Autor:Osada Y; Fujiyama T; Kamimura N; Kaji T; Nakae S; Sudo K; Ishiwata K; Kanazawa T
[Ad] Endereço:Department of Immunology and Parasitology, University of Occupational and Environmental Health, 1-1, Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan. Electronic address: yosada@med.uoeh-u.ac.jp.
[Ti] Título:Dual genetic absence of STAT6 and IL-10 does not abrogate anti-hyperglycemic effects of Schistosoma mansoni in streptozotocin-treated diabetic mice.
[So] Source:Exp Parasitol;177:1-12, 2017 Jun.
[Is] ISSN:1090-2449
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Schistosoma mansoni (Sm) is known to exert protective effects against various allergic and autoimmune disorders. It has been reported that this parasite protects NOD mice from spontaneous type 1 diabetes (T1D) and ameliorates streptozotocin (STZ)-induced T1D in wild-type mice. Here, we tried to clarify the anti-diabetic mechanisms of Sm in the latter model. Sm infection partially prevented the degradation of pancreatic islets and hyperglycemia in multiple low-dose (MLD) STZ-treated mice. Neither Treg cell depletion nor genetic absences of IL-10 and/or STAT6 abrogated the anti-hyperglycemic effects of Sm. Among M2 macrophage markers, Arg-1 and Ym1, but not Retnla, remained up-regulated in the pancreatic lymph nodes and in the spleens of STAT6/IL-10 double deficient (DKO) mice. Collectively, it is suggested that Sm exerts anti-diabetic effects on this experimental T1D model via Treg/IL-4/IL-13/IL-10-independent mechanisms. Augmented expressions of Arg-1 and Ym1 in the lymphoid organs adjacent to pancreas may be relevant to the anti-diabetic effects of Sm.
[Mh] Termos MeSH primário: Diabetes Mellitus Experimental/genética
Diabetes Mellitus Tipo 1/genética
Interleucina-10/genética
Fator de Transcrição STAT6/genética
Esquistossomose mansoni/complicações
[Mh] Termos MeSH secundário: Animais
Biomphalaria
Glicemia/metabolismo
Diabetes Mellitus Experimental/parasitologia
Diabetes Mellitus Experimental/prevenção & controle
Diabetes Mellitus Tipo 1/induzido quimicamente
Diabetes Mellitus Tipo 1/parasitologia
Regulação da Expressão Gênica
Injeções Intraperitoneais
Interleucina-10/metabolismo
Interleucina-13/genética
Interleucina-13/metabolismo
Interleucina-4/genética
Interleucina-4/metabolismo
Ilhotas Pancreáticas/patologia
Linfonodos/citologia
Linfonodos/imunologia
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Camundongos Endogâmicos ICR
Camundongos Endogâmicos NOD
Camundongos Knockout
Fator de Transcrição STAT6/metabolismo
Esquistossomose mansoni/sangue
Organismos Livres de Patógenos Específicos
Baço/imunologia
Estreptozocina/administração & dosagem
Linfócitos T/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Blood Glucose); 0 (Interleukin-13); 0 (STAT6 Transcription Factor); 0 (Stat6 protein, mouse); 130068-27-8 (Interleukin-10); 207137-56-2 (Interleukin-4); 5W494URQ81 (Streptozocin)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170620
[Lr] Data última revisão:
170620
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170402
[St] Status:MEDLINE


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[PMID]:28362351
[Au] Autor:Martins MC; Silva MC; Silva HA; Silva LR; Albuquerque MC; Aires AL; Falcão EP; Pereira EC; de Melo AM; da Silva NH
[Ad] Endereço:Departamento de Bioquímica e Fisiologia, Universidade Federal de Pernambuco, Recife, PE 50670-901, Brazil. monicabarmartins@hotmail.com.
[Ti] Título:Barbatic Acid Offers a New Possibility for Control of Biomphalaria Glabrata and Schistosomiasis.
[So] Source:Molecules;22(4), 2017 Mar 31.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:This study evaluated the biological activity of an ether extract and barbatic acid (BAR) from on embryos and adult mollusks of , cercariae of and the microcrustacean . The ether extract and BAR were obtained by successive extractions with diethyl ether. The obtained extracts were analyzed using thin-layer chromatography (TLC), high-performance liquid chromatography (HPLC), proton nuclear magnetic resonance (¹H-NMR) and infrared (IR) spectroscopy. The results demonstrated that the ether extract exerted embryotoxic effects at 50 and 100 µg/mL and molluscicidal effects at 20 and 25 µg/mL. BAR exhibited no embryotoxicity, and its molluscicidal concentration was equal to that of the ether extract. However, after 60 min of exposure, 1 µg/mL BAR presented cercaricidal activity against the parasite at the second larval stage. Neither substance induced toxicity against . These results indicate the potential molluscicidal activities of the ether extract and BAR against and cercariae. In addition to these effects, there was a lack of toxicity against the aquatic environment and no damage to the biota, indicating the potential of these products for large-scale control and/or eradication of schistosomiasis.
[Mh] Termos MeSH primário: Biomphalaria/efeitos dos fármacos
Ácidos Ftálicos/farmacologia
Ácidos Ftálicos/uso terapêutico
Esquistossomose/tratamento farmacológico
[Mh] Termos MeSH secundário: Animais
Artemia/efeitos dos fármacos
Embrião não Mamífero/efeitos dos fármacos
Éter
Moluscocidas/química
Moluscocidas/farmacologia
Moluscocidas/uso terapêutico
Ácidos Ftálicos/química
Extratos Vegetais/química
Extratos Vegetais/farmacologia
Extratos Vegetais/uso terapêutico
Extratos Vegetais/toxicidade
Schistosoma mansoni/efeitos dos fármacos
Esquistossomose/parasitologia
Testes de Toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Molluscacides); 0 (Phthalic Acids); 0 (Plant Extracts); 0 (barbatic acid); 0F5N573A2Y (Ether)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170523
[Lr] Data última revisão:
170523
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170401
[St] Status:MEDLINE


  10 / 2449 MEDLINE  
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[PMID]:28325369
[Au] Autor:Mitta G; Gourbal B; Grunau C; Knight M; Bridger JM; Théron A
[Ad] Endereço:University of Perpignan, Perpignan, France.
[Ti] Título:The Compatibility Between Biomphalaria glabrata Snails and Schistosoma mansoni: An Increasingly Complex Puzzle.
[So] Source:Adv Parasitol;97:111-145, 2017.
[Is] ISSN:2163-6079
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This review reexamines the results obtained in recent decades regarding the compatibility polymorphism between the snail, Biomphalaria glabrata, and the pathogen, Schistosoma mansoni, which is one of the agents responsible for human schistosomiasis. Some results point to the snail's resistance as explaining the incompatibility, while others support a "matching hypothesis" between the snail's immune receptors and the schistosome's antigens. We propose here that the two hypotheses are not exclusive, and that the compatible/incompatible status of a particular host/parasite couple probably reflects the balance of multiple molecular determinants that support one hypothesis or the other. Because these genes are involved in a coevolutionary arms race, we also propose that the underlying mechanisms can vary. Finally, some recent results show that environmental factors could influence compatibility. Together, these results make the compatibility between B. glabrata and S. mansoni an increasingly complex puzzle. We need to develop more integrative approaches in order to find targets that could potentially be manipulated to control the transmission of schistosomiasis.
[Mh] Termos MeSH primário: Biomphalaria/parasitologia
Schistosoma mansoni/fisiologia
Esquistossomose mansoni/parasitologia
[Mh] Termos MeSH secundário: Animais
Vetores de Doenças
Seres Humanos
Schistosoma mansoni/genética
Esquistossomose mansoni/transmissão
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170801
[Lr] Data última revisão:
170801
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170323
[St] Status:MEDLINE



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