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Pesquisa : B01.050.500.644.400.750.645 [Categoria DeCS]
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  1 / 2369 MEDLINE  
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[PMID]:29023569
[Au] Autor:Vulfius CA; Kasheverov IE; Kryukova EV; Spirova EN; Shelukhina IV; Starkov VG; Andreeva TV; Faure G; Zouridakis M; Tsetlin VI; Utkin YN
[Ad] Endereço:Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region, Russia.
[Ti] Título:Pancreatic and snake venom presynaptically active phospholipases A2 inhibit nicotinic acetylcholine receptors.
[So] Source:PLoS One;12(10):e0186206, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Phospholipases A2 (PLA2s) are enzymes found throughout the animal kingdom. They hydrolyze phospholipids in the sn-2 position producing lysophospholipids and unsaturated fatty acids, agents that can damage membranes. PLA2s from snake venoms have numerous toxic effects, not all of which can be explained by phospholipid hydrolysis, and each enzyme has a specific effect. We have earlier demonstrated the capability of several snake venom PLA2s with different enzymatic, cytotoxic, anticoagulant and antiproliferative properties, to decrease acetylcholine-induced currents in Lymnaea stagnalis neurons, and to compete with α-bungarotoxin for binding to nicotinic acetylcholine receptors (nAChRs) and acetylcholine binding protein. Since nAChRs are implicated in postsynaptic and presynaptic activities, in this work we probe those PLA2s known to have strong presynaptic effects, namely ß-bungarotoxin from Bungarus multicinctus and crotoxin from Crotalus durissus terrificus. We also wished to explore whether mammalian PLA2s interact with nAChRs, and have examined non-toxic PLA2 from porcine pancreas. It was found that porcine pancreatic PLA2 and presynaptic ß-bungarotoxin blocked currents mediated by nAChRs in Lymnaea neurons with IC50s of 2.5 and 4.8 µM, respectively. Crotoxin competed with radioactive α-bungarotoxin for binding to Torpedo and human α7 nAChRs and to the acetylcholine binding protein. Pancreatic PLA2 interacted similarly with these targets; moreover, it inhibited radioactive α-bungarotoxin binding to the water-soluble extracellular domain of human α9 nAChR, and blocked acetylcholine induced currents in human α9α10 nAChRs heterologously expressed in Xenopus oocytes. These and our earlier results show that all snake PLA2s, including presynaptically active crotoxin and ß-bungarotoxin, as well as mammalian pancreatic PLA2, interact with nAChRs. The data obtained suggest that this interaction may be a general property of all PLA2s, which should be proved by further experiments.
[Mh] Termos MeSH primário: Neurônios/fisiologia
Pâncreas/enzimologia
Fosfolipases A2/farmacologia
Venenos de Serpentes/enzimologia
[Mh] Termos MeSH secundário: Acetilcolina/metabolismo
Animais
Bungarotoxinas/farmacologia
Crotoxina/farmacologia
Seres Humanos
Lymnaea/citologia
Neurônios/efeitos dos fármacos
Receptores Nicotínicos/metabolismo
Suínos/metabolismo
Xenopus laevis/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bungarotoxins); 0 (Receptors, Nicotinic); 0 (Snake Venoms); 9007-40-3 (Crotoxin); EC 3.1.1.4 (Phospholipases A2); N9YNS0M02X (Acetylcholine)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171024
[Lr] Data última revisão:
171024
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171013
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0186206


  2 / 2369 MEDLINE  
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[PMID]:28521755
[Au] Autor:Groendahl S; Fink P
[Ad] Endereço:Cologne Biocenter, Workgroup Aquatic Chemical Ecology, University of Cologne, Zuelpicher Strasse 47b, 50674, Koeln, Germany. sgroenda@uni-koeln.de.
[Ti] Título:High dietary quality of non-toxic cyanobacteria for a benthic grazer and its implications for the control of cyanobacterial biofilms.
[So] Source:BMC Ecol;17(1):20, 2017 May 18.
[Is] ISSN:1472-6785
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Mass occurrences of cyanobacteria frequently cause detrimental effects to the functioning of aquatic ecosystems. Consequently, attempts haven been made to control cyanobacterial blooms through naturally co-occurring herbivores. Control of cyanobacteria through herbivores often appears to be constrained by their low dietary quality, rather than by the possession of toxins, as also non-toxic cyanobacteria are hardly consumed by many herbivores. It was thus hypothesized that the consumption of non-toxic cyanobacteria may be improved when complemented with other high quality prey. We conducted a laboratory experiment in which we fed the herbivorous freshwater gastropod Lymnaea stagnalis single non-toxic cyanobacterial and unialgal diets or a mixed diet to test if diet-mixing may enable these herbivores to control non-toxic cyanobacterial mass abundances. RESULTS: The treatments where L. stagnalis were fed non-toxic cyanobacteria and a mixed diet provided a significantly higher shell and soft-body growth rate than the average of all single algal, but not the non-toxic cyanobacterial diets. However, the increase in growth provided by the non-toxic cyanobacteria diets could not be related to typical determinants of dietary quality such as toxicity, nutrient stoichiometry or essential fatty acid content. CONCLUSIONS: These results strongly contradict previous research which describes non-toxic cyanobacteria as a low quality food resource for freshwater herbivores in general. Our findings thus have strong implications to gastropod-cyanobacteria relationships and suggest that freshwater gastropods may be able to control mass occurrences of benthic non-toxic cyanobacteria, frequently observed in eutrophied water bodies worldwide.
[Mh] Termos MeSH primário: Biofilmes
Cianobactérias/fisiologia
Lymnaea/fisiologia
[Mh] Termos MeSH secundário: Animais
Cianobactérias/química
Ecossistema
Comportamento Alimentar
Cadeia Alimentar
Herbivoria/fisiologia
Modelos Biológicos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171106
[Lr] Data última revisão:
171106
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170520
[St] Status:MEDLINE
[do] DOI:10.1186/s12898-017-0130-3


  3 / 2369 MEDLINE  
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[PMID]:28441437
[Au] Autor:Shuryak I
[Ad] Endereço:Center for Radiological Research, Columbia University, New York, NY, United States of America.
[Ti] Título:Quantitative modeling of responses to chronic ionizing radiation exposure using targeted and non-targeted effects.
[So] Source:PLoS One;12(4):e0176476, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The biological effects of chronic ionizing radiation exposure can be difficult to study, but important to understand in order to protect the health of occupationally-exposed persons and victims of radiological accidents or malicious events. They include targeted effects (TE) caused by ionizations within/close to nuclear DNA, and non-targeted effects (NTE) caused by damage to other cell structures and/or activation of stress-signaling pathways in distant cells. Data on radiation damage in animal populations exposed over multiple generations to wide ranges of dose rates after the Chernobyl nuclear-power-plant accident are very useful for enhancing our understanding of these processes. We used a mechanistically-motivated mathematical model which includes TE and NTE to analyze a large published data set on chromosomal aberrations in pond snail (Lymnaea stagnalis) embryos collected over 16 years from water bodies contaminated by Chernobyl fallout, and from control locations. The fraction of embryo cells with aberrations increased dramatically (>10-fold) and non-linearly over a dose rate range of 0.03-420 µGy/h (0.00026-3.7 Gy/year). NTE were very important for describing the non-linearity of this radiation response: the TE-only model (without NTE) performed dramatically worse than the TE+NTE model. NTE were predicted to reach ½ of maximal intensity at 2.5 µGy/h (0.022 Gy/year) and to contribute >90% to the radiation response slope at dose rates <11 µGy/h (0.1 Gy/year). Internally-incorporated 90Sr was possibly more effective per unit dose than other radionuclides. The radiation response shape for chromosomal aberrations in snail embryos was consistent with data for a different endpoint: the fraction of young amoebocytes in adult snail haemolymph. Therefore, radiation may affect different snail life stages by similar mechanisms. The importance of NTE in our model-based analysis suggests that the search for modulators of NTE-related signaling pathways could be a promising strategy for mitigating the deleterious effects of chronic irradiation.
[Mh] Termos MeSH primário: Acidente Nuclear de Chernobyl
Aberrações Cromossômicas/efeitos da radiação
Exposição Ambiental/efeitos adversos
Lymnaea/efeitos da radiação
Radiação Ionizante
[Mh] Termos MeSH secundário: Animais
Modelos Teóricos
Dose de Radiação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170426
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0176476


  4 / 2369 MEDLINE  
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[PMID]:28337747
[Au] Autor:Ford L; Crossley M; Vadukul DM; Kemenes G; Serpell LC
[Ad] Endereço:Sussex Neuroscience, School of Life Sciences, University of Sussex, Brighton, UK.
[Ti] Título:Structure-dependent effects of amyloid-ß on long-term memory in Lymnaea stagnalis.
[So] Source:FEBS Lett;591(9):1236-1246, 2017 May.
[Is] ISSN:1873-3468
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Amyloid-ß (Aß) peptides are implicated in the causation of memory loss, neuronal impairment, and neurodegeneration in Alzheimer's disease. Our recent work revealed that Aß 1-42 and Aß 25-35 inhibit long-term memory (LTM) recall in Lymnaea stagnalis (pond snail) in the absence of cell death. Here, we report the characterization of the active species prepared under different conditions, describe which Aß species is present in brain tissue during the behavioral recall time point and relate the sequence and structure of the oligomeric species to the resulting neuronal properties and effect on LTM. Our results suggest that oligomers are the key toxic Aß1-42 structures, which likely affect LTM through synaptic plasticity pathways, and that Aß 1-42 and Aß 25-35 cannot be used as interchangeable peptides.
[Mh] Termos MeSH primário: Peptídeos beta-Amiloides/farmacologia
Lymnaea/efeitos dos fármacos
Memória de Longo Prazo/efeitos dos fármacos
Fragmentos de Peptídeos/farmacologia
[Mh] Termos MeSH secundário: Peptídeos beta-Amiloides/química
Peptídeos beta-Amiloides/ultraestrutura
Animais
Fenômenos Eletrofisiológicos/efeitos dos fármacos
Hemolinfa/efeitos dos fármacos
Hemolinfa/fisiologia
Lymnaea/fisiologia
Memória de Longo Prazo/fisiologia
Microscopia Eletrônica de Transmissão
Neurônios/efeitos dos fármacos
Neurônios/fisiologia
Técnicas de Patch-Clamp
Fragmentos de Peptídeos/química
Fragmentos de Peptídeos/ultraestrutura
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amyloid beta-Peptides); 0 (Peptide Fragments); 0 (amyloid beta-protein (1-42)); 0 (amyloid beta-protein (25-35))
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170918
[Lr] Data última revisão:
170918
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170325
[St] Status:MEDLINE
[do] DOI:10.1002/1873-3468.12633


  5 / 2369 MEDLINE  
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[PMID]:28283412
[Au] Autor:Young A; Protheroe A; Lukowiak K
[Ad] Endereço:Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, T2N 4N1, Canada.
[Ti] Título:Silver nanoparticles alter learning and memory formation in an aquatic organism, Lymnaea stagnalis.
[So] Source:Environ Pollut;225:403-411, 2017 Jun.
[Is] ISSN:1873-6424
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:We tested the effect of silver nanoparticles (AgNPs) on the ability of the pond snail, Lymnaea stagnalis, to learn and form long-term memory (LTM) following operant conditioning of aerial respiration. We hypothesized that the AgNPs would act as a stressor and prevent learning and LTM formation. We tested snails exposed for either 72 h or only during training and testing for memory (i.e. 0.5 h) and found no difference between those treatments. We found that at a low concentration of AgNPs (5 µg/L) neither learning and nor memory formation were altered. When we increased the concentration of AgNPs (10 µg/L) we found that memory formation was enhanced. Finally, at a higher concentration (50 µg/L) memory formation was blocked. To determine if the disassociation of Ag from the AgNPs caused the effects on memory we performed similar experiments with AgNO and found similar concentration-dependent results. Finally, we found that snails perceive the AgNPs differently from Ag+ as there was context specific memory. That is, snails trained in AgNPs did not show memory when tested in Ag and vice-versa. We believe that changes in memory formation may be a more sensitive determination of AgNPs on aquatic organisms than the determination of a LC .
[Mh] Termos MeSH primário: Lymnaea/fisiologia
Nanopartículas/toxicidade
Prata/toxicidade
Poluentes Químicos da Água/toxicidade
[Mh] Termos MeSH secundário: Animais
Organismos Aquáticos
Condicionamento Operante
Aprendizagem/efeitos dos fármacos
Lymnaea/efeitos dos fármacos
Memória/efeitos dos fármacos
Caramujos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Water Pollutants, Chemical); 3M4G523W1G (Silver)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170804
[Lr] Data última revisão:
170804
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170312
[St] Status:MEDLINE


  6 / 2369 MEDLINE  
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[PMID]:28274592
[Au] Autor:Reátegui-Zirena EG; Fidder BN; Olson AD; Dawson DE; Bilbo TR; Salice CJ
[Ad] Endereço:Department of Environmental Toxicology, The Institute of Environmental and Human Health (TIEHH), Texas Tech University, Lubbock, TX, USA. Electronic address: evelyn.reategui@ttu.edu.
[Ti] Título:Transgenerational endpoints provide increased sensitivity and insight into multigenerational responses of Lymnaea stagnalis exposed to cadmium.
[So] Source:Environ Pollut;224:572-580, 2017 May.
[Is] ISSN:1873-6424
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Ecotoxicology provides data to inform environmental management. Many testing protocols do not consider offspring fitness and toxicant sensitivity. Cadmium (Cd) is a well-studied and ubiquitous toxicant but little is known about the effects on offspring of exposed parents (transgenerational effects). This study had three objectives: to identify endpoints related to offspring performance; to determine whether parental effects would manifest as a change in Cd tolerance in offspring and how parental exposure duration influenced the manifestation of parental effects. Adult snails were exposed to Cd 0, 25, 50, 100, 200 and 400 µg Cd/L for eight weeks. There were effects on adult endpoints (e.g., growth, reproduction) but only at the highest concentrations (>100 µg/L). Alternatively, we observed significant transgenerational effects at all Cd concentrations. Surprisingly, we found increased Cd tolerance in hatchlings from all parental Cd exposure concentrations even though eggs and hatchlings were in Cd-free conditions for 6 weeks. Explicit consideration of offspring performance adds value to current toxicity testing protocols. Parental exposure duration has important implications for offspring effects and that contaminant concentrations that are not directly toxic to parents can cause transgenerational changes in resistance that have significant implications for toxicity testing and adaptive responses.
[Mh] Termos MeSH primário: Cádmio/toxicidade
Lymnaea/efeitos dos fármacos
Poluentes Químicos da Água/toxicidade
[Mh] Termos MeSH secundário: Animais
Relação Dose-Resposta a Droga
Tolerância a Medicamentos
Ecotoxicologia/métodos
Determinação de Ponto Final
Lymnaea/crescimento & desenvolvimento
Lymnaea/fisiologia
Reprodução/efeitos dos fármacos
Testes de Toxicidade/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Water Pollutants, Chemical); 00BH33GNGH (Cadmium)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170529
[Lr] Data última revisão:
170529
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170310
[St] Status:MEDLINE


  7 / 2369 MEDLINE  
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[PMID]:28250177
[Au] Autor:Hughes E; Shymansky T; Swinton E; Lukowiak KS; Swinton C; Sunada H; Protheroe A; Phillips I; Lukowiak K
[Ad] Endereço:Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, 3330 Hospital Dr NW, Calgary, Alberta T2N 4N1, Canada.
[Ti] Título:Strain-specific differences of the effects of stress on memory in .
[So] Source:J Exp Biol;220(Pt 5):891-899, 2017 Mar 01.
[Is] ISSN:1477-9145
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Stress alters the ability to form, recall and maintain memory according to the Yerkes-Dodson/Hebb (YDH) law. The effects of environmentally relevant stressors, such as low environmental calcium and crowding, on learning and memory have previously been described in a laboratory-reared 'average' strain of (i.e. the Dutch strain) as well as two strains of freshly collected with enhanced memory formation abilities (i.e. 'smart' snails). Here, we use to study the effects of other environmentally relevant stressors on memory formation in two other strains of freshly collected snails, one 'smart' and one 'average'. The stressors we examined are thermal, resource restriction combined with food odour, predator detection and, for the first time, tissue injury (shell damage). We show that the same stressor has significantly different effects on memory formation depending on whether snails are 'smart' or 'average'. Specifically, our data suggest that a stressor or a combination of stressors act to enhance memory in 'average' snails but obstruct memory formation in 'smart' snails. These results are consistent with the YDH law and our hypothesis that 'smart' snails are more easily stressed than 'average' snails.
[Mh] Termos MeSH primário: Lymnaea/fisiologia
Estresse Fisiológico
[Mh] Termos MeSH secundário: Animais
Comportamento Animal
Cálcio/metabolismo
Condicionamento Operante
Aglomeração
Meio Ambiente
Privação de Alimentos
Memória
Comportamento Predatório
Especificidade da Espécie
Temperatura Ambiente
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
SY7Q814VUP (Calcium)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170829
[Lr] Data última revisão:
170829
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170303
[St] Status:MEDLINE
[do] DOI:10.1242/jeb.149161


  8 / 2369 MEDLINE  
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[PMID]:28148214
[Au] Autor:Sunada H; Lukowiak K; Ito E
[Ad] Endereço:1 Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University, Sanuki 769-2193, Japan.
[Ti] Título:Cerebral Giant Cells are Necessary for the Formation and Recall of Memory of Conditioned Taste Aversion in Lymnaea.
[So] Source:Zoolog Sci;34(1):72-80, 2017 Feb.
[Is] ISSN:0289-0003
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:The pond snail Lymnaea stagnalis can acquire conditioned taste aversion (CTA) as a long-term memory. CTA is caused by the temporal pairing of a stimulus, such as sucrose (the conditioned stimulus; CS), with another stimulus, such as electric shock (the unconditioned stimulus; US). Previous studies have demonstrated changes in both cellular and molecular properties in a pair of neurons known as the cerebral giant cells (CGCs), suggesting that these neurons play a key role in CTA. Here we examined the necessity of the pair of CGC somata for the learning, memory formation and memory recall of CTA by using the soma ablation technique. There was no difference in the feeding response elicited by the CS before and after ablation of the CGC somata. Ablation of the CGC somata before taste-aversion training resulted in the learning acquisition, but the memory formation was not observed 24 h later. We next asked whether memory was present when the CGC somata were ablated 24 h after taste-aversion training. The memory was present before performing the somata ablation. However, when we tested snails five days after somata ablation, the memory recall was not present. Together the data show that: 1) the somata of the CGCs are not necessary for learning acquisition; 2) the somata are necessary for memory formation; and 3) the somata are necessary for memory recall. That is, these results demonstrate that the CGCs function in the long-term memory of CTA in Lymnaea.
[Mh] Termos MeSH primário: Células Gigantes/fisiologia
Lymnaea/citologia
Lymnaea/fisiologia
Neurônios/fisiologia
Paladar/fisiologia
[Mh] Termos MeSH secundário: Animais
Memória/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170622
[Lr] Data última revisão:
170622
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170203
[St] Status:MEDLINE
[do] DOI:10.2108/zs160152


  9 / 2369 MEDLINE  
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[PMID]:27932040
[Au] Autor:Johnston CU; Clothier LN; Quesnel DM; Gieg LM; Chua G; Hermann PM; Wildering WC
[Ad] Endereço:Department of Biological Sciences, Faculty of Science, University of Calgary, Calgary, AB, T2N 1N4, Canada.
[Ti] Título:Embryonic exposure to model naphthenic acids delays growth and hatching in the pond snail Lymnaea stagnalis.
[So] Source:Chemosphere;168:1578-1588, 2017 Feb.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Naphthenic acids (NAs), a class of structurally diverse carboxylic acids with often complex ring structures and large aliphatic tail groups, are important by-products of many petrochemical processes including the oil sands mining activity of Northern Alberta. While it is evident that NAs have both acute and chronic harmful effects on many organisms, many aspects of their toxicity remain to be clarified. Particularly, while substantive data sets have been collected on NA toxicity in aquatic prokaryote and vertebrate model systems, to date, nothing is known about the toxic effects of these compounds on the embryonic development of aquatic invertebrate taxa, including freshwater mollusks. This study examines under laboratory conditions the toxicity of NAs extracted from oil sands process water (OSPW) and the low-molecular weight model NAs cyclohexylsuccinic acid (CHSA), cyclohexanebutyric acid (CHBA), and 4-tert-butylcyclohexane carboxylic acid (4-TBCA) on embryonic development of the snail Lymnaea stagnalis, a common freshwater gastropod with a broad Palearctic distribution. Evidence is provided for concentration-dependent teratogenic effects of both OSPW-derived and model NAs with remarkably similar nominal threshold concentrations between 15 and 20 mg/L and 28d EC of 31 mg/L. In addition, the data provide evidence for substantial toxicokinetic differences between CHSA, CHBA and 4-TBCA. Together, our study introduces Lymnaea stagnalis embryonic development as an effective model to assay NA-toxicity and identifies molecular architecture as a potentially important toxicokinetic parameter in the toxicity of low-molecular weight NA in embryonic development of aquatic gastropods.
[Mh] Termos MeSH primário: Ácidos Carboxílicos/toxicidade
Lymnaea/efeitos dos fármacos
Lymnaea/crescimento & desenvolvimento
Poluentes Químicos da Água/toxicidade
[Mh] Termos MeSH secundário: Alberta
Animais
Ácidos Carboxílicos/química
Mineração
Campos de Petróleo e Gás/química
Tanques/análise
Poluentes Químicos da Água/análise
Poluentes Químicos da Água/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Carboxylic Acids); 0 (Water Pollutants, Chemical); YNM5U6B7A4 (naphthenic acid)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170130
[Lr] Data última revisão:
170130
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161210
[St] Status:MEDLINE


  10 / 2369 MEDLINE  
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[PMID]:27925174
[Au] Autor:Langeloh L; Behrmann-Godel J; Seppälä O
[Ad] Endereço:Eawag, Swiss Federal Institute of Aquatic Science and Technology, 8600, Dübendorf, Switzerland.
[Ti] Título:Natural selection on immune defense: A field experiment.
[So] Source:Evolution;71(2):227-237, 2017 Feb.
[Is] ISSN:1558-5646
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Predicting the evolution of phenotypic traits requires an understanding of natural selection on them. Despite its indispensability in the fight against parasites, selection on host immune defense has remained understudied. Theory predicts immune traits to be under stabilizing selection due to associated trade-offs with other fitness-related traits. Empirical studies, however, report mainly positive directional selection. This discrepancy could be caused by low phenotypic variation in the examined individuals and/or variation in host resource level that confounds trade-offs in empirical studies. In a field experiment where we maintained Lymnaea stagnalis snails individually in cages in a lake, we investigated phenotypic selection on two immune defense traits, phenoloxidase (PO)-like activity and antibacterial activity, in hemolymph. We used a diverse laboratory population and manipulated snail resource level by limiting their food supply. For six weeks, we followed immune activity, growth, and two fitness components, survival and fecundity of snails. We found that PO-like activity and growth were under stabilizing selection, while antibacterial activity was under positive directional selection. Selection on immune traits was mainly driven by variation in survival. The form of selection on immune defense apparently depends on the particular trait, possibly due to its importance for countering the present parasite community.
[Mh] Termos MeSH primário: Imunidade Inata
Lymnaea/genética
Lymnaea/imunologia
Seleção Genética
[Mh] Termos MeSH secundário: Animais
Antibacterianos/metabolismo
Fertilidade
Aptidão Genética
Hemolinfa/química
Longevidade
Lymnaea/enzimologia
Lymnaea/crescimento & desenvolvimento
Monofenol Mono-Oxigenase/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); EC 1.14.18.1 (Monophenol Monooxygenase)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161208
[St] Status:MEDLINE
[do] DOI:10.1111/evo.13148



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