Base de dados : MEDLINE
Pesquisa : B01.050.500.714 [Categoria DeCS]
Referências encontradas : 3873 [refinar]
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  1 / 3873 MEDLINE  
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[PMID]:29231143
[Au] Autor:Vazquez-Prieto S; Paniagua E; Solana H; Ubeira FM
[Ad] Endereço:Laboratorio de Biologia Celular y Molecular, Centro de Investigacion Veterinaria de Tandil (CIVETAN), CONICET, Facultad de Ciencias Veterinarias, UNCPBA, Tandil, Argentina.
[Ti] Título:Complex Network Study of the Immune Epitope Database for Parasitic Organisms.
[So] Source:Curr Top Med Chem;17(30):3249-3255, 2018 Feb 09.
[Is] ISSN:1873-4294
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Complex network approach allows the representation and analysis of complex systems of interacting agents in an ordered and effective manner, thus increasing the probability of discovering significant properties of them. In the present study, we defined and built for the first time a complex network based on data obtained from Immune Epitope Database for parasitic organisms. We then considered the general topology, the node degree distribution, and the local structure (triadic census) of this network. In addition, we calculated 9 node centrality measures for observed network and reported a comparative study of the real network with three theoretical models to detect similarities or deviations from these ideal networks. RESULT: The results obtained corroborate the utility of the complex network approach for handling information and data mining within the database under study. CONCLUSION: They confirm that this type of approach can be considered a valuable tool for preliminary screening of the best experimental conditions to determine whether the amino acid sequences being studied are true epitopes or not.
[Mh] Termos MeSH primário: Bases de Dados Factuais
Epitopos/química
Epitopos/imunologia
Redes Neurais (Computação)
Parasitos/química
Parasitos/imunologia
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Animais
Mineração de Dados
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Epitopes)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171213
[St] Status:MEDLINE
[do] DOI:10.2174/1568026618666171211150605


  2 / 3873 MEDLINE  
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[PMID]:27774815
[Au] Autor:Kassegne K; Abe EM; Chen JH; Zhou XN
[Ad] Endereço:a National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, WHO Collaborating Centre for Tropical Diseases, National Center for International Research on Tropical Diseases, Key Laboratory of Parasite and Vector Biology of the Chinese Ministry of Health , Shanghai ,
[Ti] Título:Immunomic approaches for antigen discovery of human parasites.
[So] Source:Expert Rev Proteomics;13(12):1091-1101, 2016 12.
[Is] ISSN:1744-8387
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Genetics combined with proteomics allows for a better understanding of parasite-host interactions and host immune responses. Immunomics elucidates that antigens are targets of induced or naturally acquired immunity (NAI), a promising solution to the challenge of eradicating human infections. High-throughput protein microarrays enhance rapid antigen discovery for the development of serodiagnostic tests/vaccines. Areas covered: This review systematically analyzes the emergence of protein microarrays as a powerful technology for parasite antigen discovery and subsequently summarizes some of the attributes and disadvantages of these approaches. Major insights on novel/validated serological biomarkers or vaccine candidates against malaria and Neglected Tropical Diseases (NTDs) are highlighted. We conclude with a brief description of the processes involved in immunomic protein microarrays. Expert commentary: Interesting discoveries have been made using protein microarrays. However, there is a need to evaluate targets that elicit strong immunogenicity and correlates of protective efficacy to aid prioritization and guide further clinical development. The goal of parasitic disease elimination will be best achieved through an integrated strategy that will incorporate and implement the different control components.
[Mh] Termos MeSH primário: Antígenos de Helmintos
Parasitos/imunologia
Análise Serial de Proteínas/métodos
Proteômica/métodos
Vacinas
[Mh] Termos MeSH secundário: Animais
Ensaios de Triagem em Larga Escala/métodos
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antigens, Helminth); 0 (Vaccines)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161108
[St] Status:MEDLINE


  3 / 3873 MEDLINE  
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[PMID]:29241036
[Au] Autor:Rea E; Holder AA; Tewari R
[Ad] Endereço:School of Life Sciences, Queens Medical Centre, University of Nottingham, Nottingham, UK.
[Ti] Título:Plasmodium Peekaboo: PK4 Mediates Parasite Latency.
[So] Source:Cell Host Microbe;22(6):724-725, 2017 12 13.
[Is] ISSN:1934-6069
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In this issue of Cell Host & Microbe, Zhang et al. (2017) show that translational repression through eIF2α phosphorylation mediated by PK4 kinase activity plays a key role in artemisinin resistance in recrudescent malaria infections. Targeting this druggable process could extend the lifespan of current frontline treatments.
[Mh] Termos MeSH primário: Parasitos
Plasmodium
[Mh] Termos MeSH secundário: Animais
Antimaláricos
Resistência a Medicamentos/efeitos dos fármacos
Fator de Iniciação 2 em Eucariotos
Malária
Malária Falciparum
Fosforilação
Plasmodium falciparum
[Pt] Tipo de publicação:JOURNAL ARTICLE; COMMENT
[Nm] Nome de substância:
0 (Antimalarials); 0 (Eukaryotic Initiation Factor-2)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180227
[Lr] Data última revisão:
180227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171215
[St] Status:MEDLINE


  4 / 3873 MEDLINE  
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[PMID]:29326260
[Au] Autor:Carlton JM
[Ad] Endereço:Center for Genomics and Systems Biology, Department of Biology, New York University, New York, NY 10003, USA. jane.carlton@nyu.edu.
[Ti] Título:Malaria parasite evolution in a test tube.
[So] Source:Science;359(6372):159-160, 2018 01 12.
[Is] ISSN:1095-9203
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Parasitos
Plasmodium
[Mh] Termos MeSH secundário: Animais
Evolução Biológica
Interações Hospedeiro-Parasita
Seres Humanos
Malária/parasitologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; COMMENT
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180113
[St] Status:MEDLINE
[do] DOI:10.1126/science.aar4189


  5 / 3873 MEDLINE  
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[PMID]:28460996
[Au] Autor:Rosado-García FM; Guerrero-Flórez M; Karanis G; Hinojosa MDC; Karanis P
[Ad] Endereço:State Key Laboratory of Plateau Ecology and Agriculture, Center for Biomedicine and Infectious Diseases, Qinghai Academy of Animal Science and Veterinary Medicine, Qinghai University, Xining, Qinghai, PR China; National Institute of Hygiene, Epidemiology and Microbiology of Cuba, Cuba.
[Ti] Título:Water-borne protozoa parasites: The Latin American perspective.
[So] Source:Int J Hyg Environ Health;220(5):783-798, 2017 07.
[Is] ISSN:1618-131X
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Health systems, sanitation and water access have certain limitations in nations of Latin America (LA): typical matters of developing countries. Water is often contaminated and therefore unhealthy for the consumers and users. Information on prevalence and detection of waterborne parasitic protozoa are limited or not available in LA. Only few reports have documented in this field during the last forty years and Brazil leads the list, including countries in South America and Mexico within Central America region and Caribbean islands. From 1979 to 2015, 16 outbreaks of waterborne-protozoa, were reported in Latin American countries. T. gondii and C. cayetanensis were the protozoa, which caused more outbreaks and Giardia spp. and Cryptosporidium spp. were the most frequently found protozoa in water samples. On the other hand, Latin America countries have not got a coherent methodology for detection of protozoa in water samples despite whole LA is highly vulnerable to extreme weather events related to waterborne-infections; although Brazil and Colombia have some implemented laws in their surveillance systems. It would be important to coordinate all surveillance systems in between all countries for early detection and measures against waterborne-protozoan and to establish effective and suitable diagnosis tools according to the country's economic strength and particular needs.
[Mh] Termos MeSH primário: Parasitos/isolamento & purificação
Microbiologia da Água
Poluentes da Água/isolamento & purificação
[Mh] Termos MeSH secundário: Animais
Mudança Climática
Monitoramento Ambiental
Seres Humanos
América Latina
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Water Pollutants)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180206
[Lr] Data última revisão:
180206
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE


  6 / 3873 MEDLINE  
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[PMID]:29261775
[Au] Autor:Elia M; Blancato G; Picchi L; Lucas C; Bagnères AG; Lorenzi MC
[Ad] Endereço:Department of Life Sciences and Systems Biology, University of Turin, Torino, Italy.
[Ti] Título:Nest signature changes throughout colony cycle and after social parasite invasion in social wasps.
[So] Source:PLoS One;12(12):e0190018, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Social insects recognize their nestmates by means of a cuticular hydrocarbon signature shared by colony members, but how nest signature changes across time has been rarely tested in longitudinal studies and in the field. In social wasps, the chemical signature is also deposited on the nest surface, where it is used by newly emerged wasps as a reference to learn their colony odor. Here, we investigate the temporal variations of the chemical signature that wasps have deposited on their nests. We followed the fate of the colonies of the social paper wasp Polistes biglumis in their natural environment from colony foundation to decline. Because some colonies were invaded by the social parasite Polistes atrimandibularis, we also tested the effects of social parasites on the nest signature. We observed that, as the season progresses, the nest signature changed; the overall abundance of hydrocarbons as well as the proportion of longer-chain and branched hydrocarbons increased. Where present, social parasites altered the host-nest signature qualitatively (adding parasite-specific alkenes) and quantitatively (by interfering with the increase in overall hydrocarbon abundance). Our results show that 1) colony odor is highly dynamic both in colonies controlled by legitimate foundresses and in those controlled by social parasites; 2) emerged offspring contribute little to colony signature, if at all, in comparison to foundresses; and 3) social parasites, that later mimic host signature, initially mark host nests with species-specific hydrocarbons. This study implies that important updating of the neural template used in nestmate recognition should occur in social insects.
[Mh] Termos MeSH primário: Espécies Introduzidas
Comportamento de Nidação
Comportamento Social
Vespas/fisiologia
Vespas/parasitologia
[Mh] Termos MeSH secundário: Animais
Cromatografia Gasosa
Hidrocarbonetos/análise
Parasitos/fisiologia
Análise de Componente Principal
Estações do Ano
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hydrocarbons)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171221
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190018


  7 / 3873 MEDLINE  
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[PMID]:29227932
[Au] Autor:Pisoschi AM; Pop A; Georgescu C; Turcus V; Olah NK; Mathe E
[Ad] Endereço:University of Agronomic Sciences and Veterinary Medicine of Bucharest, Faculty of Veterinary Medicine, 105 Splaiul Independentei, 050097, Sector 5, Bucharest, Romania. Electronic address: aureliamagdalenapisoschi@yahoo.ro.
[Ti] Título:An overview of natural antimicrobials role in food.
[So] Source:Eur J Med Chem;143:922-935, 2018 Jan 01.
[Is] ISSN:1768-3254
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:The present paper aims to review the natural food preservatives with antimicrobial properties emphasizing their importance for the future of food manufacturing and consumers' health. The extraction procedures applied to natural antimicrobials will be considered, followed by the description of some natural preservatives' antimicrobial mechanism of action, including (i) membrane rupture with ATP-ase activity inhibition, (ii) leakage of essential biomolecules from the cell, (iii) disruption of the proton motive force and (iiii) enzyme inactivation. Moreover, a provenance-based classification of natural antimicrobials is discussed by considering the sources of origin for the major natural preservative categories: plants, animals, microbes and fungi. As well, the structure influence on the antimicrobial potential is considered. Natural preservatives could also constitute a viable alternative to address the critical problem of microbial resistance, and to hamper the negative side effects of some synthetic compounds, while meeting the requirements for food safety, and exerting no negative impact on nutritional and sensory attributes of foodstuffs.
[Mh] Termos MeSH primário: Anti-Infecciosos/farmacologia
Bactérias/efeitos dos fármacos
Produtos Biológicos/farmacologia
Conservantes de Alimentos/farmacologia
Fungos/efeitos dos fármacos
Parasitos/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Anti-Infecciosos/química
Anti-Infecciosos/isolamento & purificação
Produtos Biológicos/química
Produtos Biológicos/isolamento & purificação
Conservantes de Alimentos/química
Conservantes de Alimentos/isolamento & purificação
Seres Humanos
Testes de Sensibilidade Microbiana
Testes de Sensibilidade Parasitária
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Biological Products); 0 (Food Preservatives)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180101
[Lr] Data última revisão:
180101
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171212
[St] Status:MEDLINE


  8 / 3873 MEDLINE  
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[PMID]:29095820
[Au] Autor:Marzano V; Mancinelli L; Bracaglia G; Del Chierico F; Vernocchi P; Di Girolamo F; Garrone S; Tchidjou Kuekou H; D'Argenio P; Dallapiccola B; Urbani A; Putignani L
[Ad] Endereço:Human Microbiome Unit, Bambino Gesù Children's Hospital IRCCS, Rome, Italy.
[Ti] Título:"Omic" investigations of protozoa and worms for a deeper understanding of the human gut "parasitome".
[So] Source:PLoS Negl Trop Dis;11(11):e0005916, 2017 Nov.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The human gut has been continuously exposed to a broad spectrum of intestinal organisms, including viruses, bacteria, fungi, and parasites (protozoa and worms), over millions of years of coevolution, and plays a central role in human health. The modern lifestyles of Western countries, such as the adoption of highly hygienic habits, the extensive use of antimicrobial drugs, and increasing globalisation, have dramatically altered the composition of the gut milieu, especially in terms of its eukaryotic "citizens." In the past few decades, numerous studies have highlighted the composition and role of human intestinal bacteria in physiological and pathological conditions, while few investigations exist on gut parasites and particularly on their coexistence and interaction with the intestinal microbiota. Studies of the gut "parasitome" through "omic" technologies, such as (meta)genomics, transcriptomics, proteomics, and metabolomics, are herein reviewed to better understand their role in the relationships between intestinal parasites, host, and resident prokaryotes, whether pathogens or commensals. Systems biology-based profiles of the gut "parasitome" under physiological and severe disease conditions can indeed contribute to the control of infectious diseases and offer a new perspective of omics-assisted tropical medicine.
[Mh] Termos MeSH primário: Trato Gastrointestinal/parasitologia
Genômica
Interações Hospedeiro-Parasita
Metabolômica
Parasitos/fisiologia
Proteômica
[Mh] Termos MeSH secundário: Animais
Entamoeba histolytica/genética
Entamoeba histolytica/metabolismo
Microbioma Gastrointestinal
Giardia/genética
Giardia/metabolismo
Helmintos/genética
Helmintos/fisiologia
Seres Humanos
Camundongos
Taenia solium/genética
Taenia solium/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171119
[Lr] Data última revisão:
171119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171103
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0005916


  9 / 3873 MEDLINE  
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[PMID]:29049371
[Au] Autor:Courtenay O; Peters NC; Rogers ME; Bern C
[Ad] Endereço:School of Life Sciences, University of Warwick, Coventry, United Kingdom.
[Ti] Título:Combining epidemiology with basic biology of sand flies, parasites, and hosts to inform leishmaniasis transmission dynamics and control.
[So] Source:PLoS Pathog;13(10):e1006571, 2017 Oct.
[Is] ISSN:1553-7374
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Quantitation of the nonlinear heterogeneities in Leishmania parasites, sand fly vectors, and mammalian host relationships provides insights to better understand leishmanial transmission epidemiology towards improving its control. The parasite manipulates the sand fly via production of promastigote secretory gel (PSG), leading to the "blocked sand fly" phenotype, persistent feeding attempts, and feeding on multiple hosts. PSG is injected into the mammalian host with the parasite and promotes the establishment of infection. Animal models demonstrate that sand flies with the highest parasite loads and percent metacyclic promastigotes transmit more parasites with greater frequency, resulting in higher load infections that are more likely to be both symptomatic and efficient reservoirs. The existence of mammalian and sand fly "super-spreaders" provides a biological basis for the spatial and temporal clustering of clinical leishmanial disease. Sand fly blood-feeding behavior will determine the efficacies of indoor residual spraying, topical insecticides, and bed nets. Interventions need to have sufficient coverage to include transmission hot spots, especially in the absence of field tools to assess infectiousness. Interventions that reduce sand fly densities in the absence of elimination could have negative consequences, for example, by interfering with partial immunity conferred by exposure to sand fly saliva. A deeper understanding of both sand fly and host biology and behavior is essential to ensuring effectiveness of vector interventions.
[Mh] Termos MeSH primário: Leishmania/parasitologia
Leishmaniose/epidemiologia
Leishmaniose/transmissão
Parasitos/parasitologia
Psychodidae/parasitologia
[Mh] Termos MeSH secundário: Animais
Interações Hospedeiro-Patógeno/imunologia
Seres Humanos
Insetos Vetores/parasitologia
Leishmaniose/parasitologia
Parasitos/patogenicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171109
[Lr] Data última revisão:
171109
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171020
[St] Status:MEDLINE
[do] DOI:10.1371/journal.ppat.1006571


  10 / 3873 MEDLINE  
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[PMID]:29045444
[Au] Autor:Rabaoarisoa CR; Rakotoarison R; Rakotonirainy NH; Mangahasimbola RT; Randrianarisoa AB; Jambou R; Vigan-Womas I; Piola P; Randremanana RV
[Ad] Endereço:Epidemiology unit, Institut Pasteur de Madagascar, Antananarivo, Madagascar.
[Ti] Título:The importance of public health, poverty reduction programs and women's empowerment in the reduction of child stunting in rural areas of Moramanga and Morondava, Madagascar.
[So] Source:PLoS One;12(10):e0186493, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Malnutrition accounts for 45% of mortality in children under five years old, despite a global mobilization against chronic malnutrition. In Madagascar, the most recent data show that the prevalence of stunting in children under five years old is still around 47.4%. This study aimed to identify the determinants of stunting in children in rural areas of Moramanga and Morondava districts to target the main areas for intervention. METHODS: A case-control study was conducted in children aged from 6 to 59.9 months, in 2014-2015. We measured the height and weight of mothers and children and collected data on child, mother and household characteristics. One stool specimen was collected from each child for intestinal parasite identification. We used a multivariate logistic regression model to identify the determinants of stunting using backwards stepwise methods. RESULTS: We included 894 and 932 children in Moramanga and in Morondava respectively. Stunting was highly prevalent in both areas, being 52.8% and 40.0% for Moramanga and Morondava, respectively. Stunting was most associated with a specific age period (12mo to 35mo) in the two study sites. Infection with Trichuris trichiura (aOR: 2.4, 95% CI: 1.1-5.3) and those belonging to poorer households (aOR: 2.3, 95% CI: 1.6-3.4) were the major risk factors in Moramanga. In Morondava, children whose mother had activities outside the household (aOR: 1.7, 95% CI: 1.2-2.5) and those perceived to be small at birth (aOR: 1.6, 95% CI: 1.1-2.1) were more likely to be stunted, whereas adequate birth spacing (≥24months) appeared protective (aOR: 0.4, 95% CI: 0.3-0.7). CONCLUSION: Interventions that could improve children's growth in these two areas include poverty reduction, women's empowerment, public health programmes focusing on WASH and increasing acceptability, and increased coverage and quality of child/maternal health services.
[Mh] Termos MeSH primário: Transtornos do Crescimento/epidemiologia
Transtornos do Crescimento/prevenção & controle
Pobreza/prevenção & controle
Poder (Psicologia)
Saúde Pública
População Rural/estatística & dados numéricos
Mulheres
[Mh] Termos MeSH secundário: Animais
Estudos de Casos e Controles
Pré-Escolar
Feminino
Seres Humanos
Lactente
Madagáscar/epidemiologia
Masculino
Modelos Teóricos
Parasitos/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171019
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0186493



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