Base de dados : MEDLINE
Pesquisa : B01.050.500.802.785 [Categoria DeCS]
Referências encontradas : 56 [refinar]
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[PMID]:28207261
[Au] Autor:Issac M; Aknin M; Gauvin-Bialecki A; De Voogd N; Ledoux A; Frederich M; Kashman Y; Carmeli S
[Ad] Endereço:School of Chemistry, Raymond and Beverly Sackler Faculty of Exact Sciences, Tel-Aviv University , Ramat Aviv, Tel-Aviv 69978, Israel.
[Ti] Título:Cyclotheonellazoles A-C, Potent Protease Inhibitors from the Marine Sponge Theonella aff. swinhoei.
[So] Source:J Nat Prod;80(4):1110-1116, 2017 Apr 28.
[Is] ISSN:1520-6025
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The extract of a sample of the sponge Theonella aff. swinhoei collected in Madagascar exhibited promising in vitro antiplasmodial activity. The antiplasmodial activity was ascribed in part to the known metabolite swinholide A. Further investigation of the extract afforded three unusual cyclic peptides, cyclotheonellazoles A-C (1-3), which contain six nonproteinogenic amino acids out of the eight acid units that compose these natural products. Among these acids the most novel were 4-propenoyl-2-tyrosylthiazole and 3-amino-4-methyl-2-oxohexanoic acid. The structure of the compounds was elucidated by interpretation of the 1D and 2D NMR data, HRESIMS, and advanced Merfay's techniques. The new compounds were found to be nanomolar inhibitors of chymotrypsin and sub-nanomolar inhibitors of elastase, but did not present antiplasmodial activity.
[Mh] Termos MeSH primário: Peptídeos Cíclicos/isolamento & purificação
Peptídeos Cíclicos/farmacologia
Poríferos/química
Inibidores de Proteases/isolamento & purificação
Inibidores de Proteases/farmacologia
Theonella/química
[Mh] Termos MeSH secundário: Animais
Quimotripsina/antagonistas & inibidores
Madagáscar
Biologia Marinha
Toxinas Marinhas/química
Toxinas Marinhas/isolamento & purificação
Estrutura Molecular
Ressonância Magnética Nuclear Biomolecular
Elastase Pancreática/antagonistas & inibidores
Peptídeos Cíclicos/química
Inibidores de Proteases/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Marine Toxins); 0 (Peptides, Cyclic); 0 (Protease Inhibitors); 0 (cyclotheonellazole A); 0 (cyclotheonellazole B); 0 (cyclotheonellazole C); 95927-67-6 (swinholide A); EC 3.4.21.1 (Chymotrypsin); EC 3.4.21.36 (Pancreatic Elastase)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170726
[Lr] Data última revisão:
170726
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170217
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jnatprod.7b00028


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[PMID]:28198609
[Au] Autor:Smith DRM; Uria AR; Helfrich EJN; Milbredt D; van Pée KH; Piel J; Goss RJM
[Ad] Endereço:School of Chemistry, University of St Andrews , St Andrews KY16 9ST, United Kingdom.
[Ti] Título:An Unusual Flavin-Dependent Halogenase from the Metagenome of the Marine Sponge Theonella swinhoei WA.
[So] Source:ACS Chem Biol;12(5):1281-1287, 2017 May 19.
[Is] ISSN:1554-8937
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Uncultured bacteria from sponges have been demonstrated to be responsible for the generation of many potent, bioactive natural products including halogenated metabolites.1 The identification of gene clusters from the metagenomes of such bacterial communities enables the discovery of enzymes that mediate new and useful chemistries and allows insight to be gained into the biogenesis of potentially pharmacologically important natural products. Here we report a new pathway to the keramamides (krm); the first functional evidence for the existence of a distinct producer in the Theonella swinhoei WA chemotype is revealed, and a key enzyme on the pathway, a unique flavin-dependent halogenase with a broad substrate specificity, with potential as a useful new biocatalytic tool, is described.
[Mh] Termos MeSH primário: Bactérias/genética
Vias Biossintéticas
Metagenoma/genética
Theonella/microbiologia
[Mh] Termos MeSH secundário: Amidas/metabolismo
Animais
Bactérias/metabolismo
Flavinas
Halogenação
Hidrolases/metabolismo
Família Multigênica
Poríferos/microbiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amides); 0 (Flavins); EC 3.- (Hydrolases)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170912
[Lr] Data última revisão:
170912
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170216
[St] Status:MEDLINE
[do] DOI:10.1021/acschembio.6b01115


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[PMID]:27548648
[Au] Autor:Takada K; Imae Y; Ise Y; Ohtsuka S; Ito A; Okada S; Yoshida M; Matsunaga S
[Ad] Endereço:Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo , Bunkyo-ku, Tokyo 113-8657, Japan.
[Ti] Título:Yakushinamides, Polyoxygenated Fatty Acid Amides That Inhibit HDACs and SIRTs, from the Marine Sponge Theonella swinhoei.
[So] Source:J Nat Prod;79(9):2384-90, 2016 Sep 23.
[Is] ISSN:1520-6025
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Yakushinamides A (1) and B (2), prolyl amides of polyoxygenated fatty acids, have been isolated from the marine sponge Theonella swinhoei as inhibitors of HDACs and SIRTs. Their planar structures were determined by interpretation of the NMR data of the intact molecules and tandem FABMS data of the methanolysis products. For the assignment of the relative configurations of the three contiguous oxymethine carbons in 1 and 2, Kishi's universal NMR database was applied to the methanolysis products. During the assignments of relative configurations of the isolated 1-hydroxy-3-methyl moiety in 1 and the isolated 1-hydroxy-2-methyl moiety in 2, we found diagnostic NMR features to distinguish each pair of diastereomers. The absolute configurations of 1 and 2 were determined by a combination of the modified Mosher's method and Marfey's method. Although the modified Mosher's method was successfully applied to the methanolysis product of 1, this method gave an ambiguous result at C-20 when applied to the methanolysis product of 2, even after oxidative cleavage of the C-14 and C-15 bond.
[Mh] Termos MeSH primário: Amidas/isolamento & purificação
Amidas/farmacologia
Ácidos Graxos/isolamento & purificação
Ácidos Graxos/farmacologia
Theonella/química
[Mh] Termos MeSH secundário: Amidas/química
Animais
Ácidos Graxos/química
Histona Desacetilases
Japão
Biologia Marinha
Estrutura Molecular
Ressonância Magnética Nuclear Biomolecular
Oceanos e Mares
Peptídeos Cíclicos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amides); 0 (Fatty Acids); 0 (Peptides, Cyclic); 0 (yakushinamide A); 0 (yakushinamide B); EC 3.5.1.98 (Histone Deacetylases)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170627
[Lr] Data última revisão:
170627
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160823
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jnatprod.6b00588


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[PMID]:27548191
[Au] Autor:Abou-Hussein DR; Youssef DT
[Ad] Endereço:Department of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia. dabouhussein@kau.edu.sa.
[Ti] Título:Mirabolides A and B; New Cytotoxic Glycerides from the Red Sea Sponge Theonella mirabilis.
[So] Source:Mar Drugs;14(8), 2016 Aug 18.
[Is] ISSN:1660-3397
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:As a part of our continuing work to find out bioactive lead molecules from marine invertebrates, the CHCl3 fraction of the organic extract of the Red Sea sponge Theonella mirabilis showed cytotoxic activity in our primary screen. Bioassay-guided purification of the active fractions of the sponge's extract resulted in the isolation of two new glycerides, mirabolides A and B (1 and 2), together with the reported 4-methylene sterols, conicasterol (3) and swinhosterol B (4). The structures of the compounds were assigned by interpretation of their 1D (¹H, (13)C), 2D (COSY, HSQC, HMBC, ROESY) NMR spectral data and high-resolution mass determinations. Compounds 1-4 displayed marked cytotoxic activity against human breast adenocarcinoma cell line (MCF-7) with IC50 values of 16.4, 5.18, 6.23 and 3.0 µg/mL, respectively, compared to 5.4 µg/mL observed by doxorubicin as reference drug.
[Mh] Termos MeSH primário: Antibióticos Antineoplásicos/farmacologia
Glicerídeos/farmacologia
Theonella/química
[Mh] Termos MeSH secundário: Animais
Antibióticos Antineoplásicos/química
Antibióticos Antineoplásicos/isolamento & purificação
Colesterol/análogos & derivados
Colesterol/isolamento & purificação
Colesterol/farmacologia
Doxorrubicina/farmacologia
Feminino
Glicerídeos/química
Glicerídeos/isolamento & purificação
Seres Humanos
Oceano Índico
Concentração Inibidora 50
Células MCF-7
Estrutura Molecular
Ressonância Magnética Nuclear Biomolecular
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibiotics, Antineoplastic); 0 (Glycerides); 0 (conicasterol); 0 (mirabolide A); 0 (mirabolide B); 80168379AG (Doxorubicin); 97C5T2UQ7J (Cholesterol)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170627
[Lr] Data última revisão:
170627
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160823
[St] Status:MEDLINE


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[PMID]:27547840
[Au] Autor:Jamison MT; Molinski TF
[Ad] Endereço:Department of Chemistry and Biochemistry and ‡Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego , 9500 Gilman Dr. MC-0358, La Jolla, California 92093-0358, United States.
[Ti] Título:Jamaicensamide A, a Peptide Containing ß-Amino-α-keto and Thiazole-Homologated η-Amino Acid Residues from the Sponge Plakina jamaicensis.
[So] Source:J Nat Prod;79(9):2243-9, 2016 Sep 23.
[Is] ISSN:1520-6025
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A new cyclic peptide, jamaicensamide A, composed of six amino acids, including a thiazole-homologated amino acid, was isolated from the Bahamian sponge Plakina jamaicensis, along with known compounds bitungolide A and franklinolide A. The structure of the title peptide was solved by integrated analysis of MS, 1D and 2D NMR data, oxidation-hydrolyses to α-amino acids, and their stereodetermination by Marfey's method. The close structural resemblance of Western Atlantic-derived jamaicensamide A to known Western Pacific-derived peptides of lithistid sponges in the genus Theonella and Discodermia suggests a common origin: the symbiotic bacterium Entotheonella sp., a so-called "talented producer" responsible for biosynthesis of most Theonella-associated peptides. Similar natural products from sponges of disparate genera evince the likelihood that these invertebrates harbor the same or a very similar symbiont.
[Mh] Termos MeSH primário: Produtos Biológicos/isolamento & purificação
Peptídeos Cíclicos/isolamento & purificação
Theonella/química
Tiazóis/química
[Mh] Termos MeSH secundário: Aminoácidos/química
Animais
Bahamas
Produtos Biológicos/química
Biologia Marinha
Estrutura Molecular
Ressonância Magnética Nuclear Biomolecular
Peptídeos Cíclicos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amino Acids); 0 (Biological Products); 0 (Peptides, Cyclic); 0 (Thiazoles); 0 (jamaicensamide A)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170627
[Lr] Data última revisão:
170627
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160823
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jnatprod.6b00336


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[PMID]:27213234
[Au] Autor:Fukuhara K; Takada K; Okada S; Matsunaga S
[Ad] Endereço:Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo , Bunkyo-ku, Tokyo 113-8657, Japan.
[Ti] Título:Nazumazoles D-F, Cyclic Pentapeptides That Inhibit Chymotrypsin, from the Marine Sponge Theonella swinhoei.
[So] Source:J Nat Prod;79(6):1694-7, 2016 Jun 24.
[Is] ISSN:1520-6025
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Nazumazoles D-F (1-3) were isolated from the marine sponge Theonella swinhoei. The compounds gave extremely broad peaks by reversed-phase HPLC using an ODS column. HPLC using a gel permeation column was instrumental for the separation of the three compounds. Their planar structures were determined by interpretation of NMR data to be cyclic pentapeptides. Nazumazoles D-F contained one residue each of α-keto-l-norvaline (l-Knv) {or α-keto-d-leucine (l-Kle)}, l-alanyloxazole (l-Aox), d-Abu (or d-Ser), N-α-CHO-ß-l-Dpr, and cis-4-methyl-l-proline. The absolute configuration of each amino acid residue was determined by Marfey's method in combination with conversion of the α-keto-ß-amino acid to the α-amino acid by oxidation. Nazumazoles D-F are not cytotoxic against P388 cells at 50 µM, but inhibit chymotrypsin.
[Mh] Termos MeSH primário: Peptídeos Cíclicos/isolamento & purificação
Theonella/química
[Mh] Termos MeSH secundário: Animais
Cromatografia Líquida de Alta Pressão
Biologia Marinha
Estrutura Molecular
Ressonância Magnética Nuclear Biomolecular
Peptídeos Cíclicos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Peptides, Cyclic); 0 (nazumazole D)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170517
[Lr] Data última revisão:
170517
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160524
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jnatprod.6b00261


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[PMID]:27007992
[Au] Autor:Ota K; Hamamoto Y; Eda W; Tamura K; Sawada A; Hoshino A; Mitome H; Kamaike K; Miyaoka H
[Ad] Endereço:School of Pharmacy, Tokyo University of Pharmacy and Life Sciences , 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
[Ti] Título:Amitorines A and B, Nitrogenous Diterpene Metabolites of Theonella swinhoei: Isolation, Structure Elucidation, and Asymmetric Synthesis.
[So] Source:J Nat Prod;79(4):996-1004, 2016 Apr 22.
[Is] ISSN:1520-6025
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Two new nitrogenous prenylbisabolanes never before found in Lithistid sponges have been isolated from Theonella swinhoei. These new diterpenes, named amitorine A (1) and amitorine B (2), containing a prenylbisabolane skeleton have been characterized by spectroscopic analyses, and the relative and absolute configurations of 1 and 2 were determined by asymmetric synthesis of both diastereomers via the common bicyclic lactone 6 intermediate.
[Mh] Termos MeSH primário: Diterpenos/isolamento & purificação
Theonella/química
[Mh] Termos MeSH secundário: Animais
Diterpenos/química
Diterpenos/farmacologia
Japão
Estrutura Molecular
Ressonância Magnética Nuclear Biomolecular
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Diterpenes); 0 (amitorine A); 0 (amitorine B); 0 (prenylbisabolane)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:160422
[Lr] Data última revisão:
160422
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160324
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jnatprod.5b01069


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[PMID]:26809776
[Au] Autor:Keren R; Lavy A; Ilan M
[Ad] Endereço:Department of Zoology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Ramat Aviv, Tel Aviv, 6997801, Israel. mr.ray.keren@gmail.com.
[Ti] Título:Increasing the Richness of Culturable Arsenic-Tolerant Bacteria from Theonella swinhoei by Addition of Sponge Skeleton to the Growth Medium.
[So] Source:Microb Ecol;71(4):873-86, 2016 May.
[Is] ISSN:1432-184X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Theonella swinhoei is an arsenic hyper-accumulator sponge, harboring a multitude of associated bacteria. These bacteria reside in the mesohyl, the dense extracellular matrix of the sponge. Previous elemental analysis of separated cell fractions from the sponge had determined that arsenic is localized to the associated bacteria. Subsequently, sponge-associated arsenic-tolerant bacteria were isolated here and grouped into 15 operational taxonomic units (OTUs, 97% similarity). Both culture-dependent and culture-independent work had revealed that T. swinhoei harbors a highly diverse bacterial community. It was thus hypothesized the acclimation of bacteria in the presence of a sponge skeleton, better mimicking its natural environment, would increase the yield of isolation of sponge-associated bacteria. Using seven modularly designed media, 380 bacteria isolates were grown and grouped into 22 OTUs. Inclusion of sponge skeleton in the growth medium promoted bacterial growth in all seven media, accounting for 20 of the 22 identified OTUs (the other two in a medium without skeleton). Diversity and richness indices were calculated for each treatment or combination of treatments with shared growth parameters. Integrating data inherent in the modularly designed media with the ecological indices led to the formation of new hypotheses regarding the aeration conditions and expected arsenic form in situ. Both aerobic and anoxic conditions are expected to occur in the sponge (temporally and/or spatially). Arsenate is expected to be the dominant (or even the only) arsenic form in the sponge.
[Mh] Termos MeSH primário: Arseniatos/farmacologia
Arsenitos/farmacologia
Bactérias/efeitos dos fármacos
Theonella/microbiologia
[Mh] Termos MeSH secundário: Animais
Arsênico/metabolismo
Bactérias/classificação
Bactérias/genética
Bactérias/isolamento & purificação
Biodiversidade
Meios de Cultura
Genes Bacterianos
Oceano Índico
Filogenia
RNA Ribossômico 16S/genética
Água do Mar
Simbiose
Theonella/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Arsenates); 0 (Arsenites); 0 (Culture Media); 0 (RNA, Ribosomal, 16S); N5509X556J (arsenite); N712M78A8G (Arsenic); N7CIZ75ZPN (arsenic acid)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160127
[St] Status:MEDLINE
[do] DOI:10.1007/s00248-015-0726-0


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[PMID]:26625171
[Au] Autor:Freeman MF; Vagstad AL; Piel J
[Ad] Endereço:Institute of Microbiology, Eidgenössische Technische Hochschule (ETH) Zurich, Vladimir-Prelog-Weg 4, 8093 Zurich, Switzerland.
[Ti] Título:Polytheonamide biosynthesis showcasing the metabolic potential of sponge-associated uncultivated 'Entotheonella' bacteria.
[So] Source:Curr Opin Chem Biol;31:8-14, 2016 Apr.
[Is] ISSN:1879-0402
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The vast majority of microorganisms on the planet have not been grown under laboratory conditions due to unknown metabolic and environmental constraints. This uncultivated majority has enormous potential as a reservoir of unique enzymology and biosynthetic pathways. The following review offers a glimpse into this unexplored enzymatic stockpile through recent progress made on the biosynthesis of the potent polytheonamide cytotoxins. These structurally highly complex pore-forming peptides, isolated from the marine sponge Theonella swinhoei, are synthesized by the ribosome and then modified through numerous unusual transformations including iterative epimerase and N-methyltransferase activities. The bacterial source of these metabolites was identified as the taxonomically remote, uncultivated sponge symbiont 'Entotheonella factor' with a biosynthetic prowess that rivals those of industrially exploited microorganisms.
[Mh] Termos MeSH primário: Bactérias/metabolismo
Biossíntese de Proteínas
Theonella/metabolismo
[Mh] Termos MeSH secundário: Animais
Theonella/microbiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170620
[Lr] Data última revisão:
170620
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151202
[St] Status:MEDLINE


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[PMID]:26655754
[Au] Autor:Britstein M; Devescovi G; Handley KM; Malik A; Haber M; Saurav K; Teta R; Costantino V; Burgsdorf I; Gilbert JA; Sher N; Venturi V; Steindler L
[Ad] Endereço:Department of Marine Biology, Leon H. Charney School of Marine Sciences, University of Haifa, Haifa, Israel.
[Ti] Título:A New N-Acyl Homoserine Lactone Synthase in an Uncultured Symbiont of the Red Sea Sponge Theonella swinhoei.
[So] Source:Appl Environ Microbiol;82(4):1274-85, 2015 Dec 11.
[Is] ISSN:1098-5336
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Sponges harbor a remarkable diversity of microbial symbionts in which signal molecules can accumulate and enable cell-cell communication, such as quorum sensing (QS). Bacteria capable of QS were isolated from marine sponges; however, an extremely small fraction of the sponge microbiome is amenable to cultivation. We took advantage of community genome assembly and binning to investigate the uncultured majority of sponge symbionts. We identified a complete N-acyl-homoserine lactone (AHL)-QS system (designated TswIR) and seven partial luxI homologues in the microbiome of Theonella swinhoei. The TswIR system was novel and shown to be associated with an alphaproteobacterium of the order Rhodobacterales, here termed Rhodobacterales bacterium TS309. The tswI gene, when expressed in Escherichia coli, produced three AHLs, two of which were also identified in a T. swinhoei sponge extract. The taxonomic affiliation of the 16S rRNA of Rhodobacterales bacterium TS309 to a sponge-coral specific clade, its enrichment in sponge versus seawater and marine sediment samples, and the presence of sponge-specific features, such as ankyrin-like domains and tetratricopeptide repeats, indicate a likely symbiotic nature of this bacterium.
[Mh] Termos MeSH primário: Alphaproteobacteria/enzimologia
Ligases/isolamento & purificação
Microbiota
Simbiose
Theonella/microbiologia
[Mh] Termos MeSH secundário: Acil-Butirolactonas/metabolismo
Alphaproteobacteria/classificação
Alphaproteobacteria/genética
Sequência de Aminoácidos
Animais
Clonagem Molecular
Análise por Conglomerados
DNA Bacteriano/química
DNA Bacteriano/genética
DNA Ribossômico/química
DNA Ribossômico/genética
Escherichia coli/genética
Escherichia coli/metabolismo
Expressão Gênica
Oceano Índico
Ligases/genética
Dados de Sequência Molecular
Filogenia
RNA Ribossômico 16S/genética
Alinhamento de Sequência
Análise de Sequência de DNA
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (Acyl-Butyrolactones); 0 (DNA, Bacterial); 0 (DNA, Ribosomal); 0 (RNA, Ribosomal, 16S); EC 6.- (Ligases); EC 6.1.- (N-acylhomoserine lactone synthase)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151215
[St] Status:MEDLINE
[do] DOI:10.1128/AEM.03111-15



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BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde