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[PMID]:29256280
[Au] Autor:Szoke K; Sándor AD; Boldogh SA; Görföl T; Votýpka J; Takács N; Estók P; Kováts D; Corduneanu A; Molnár V; Kontschán J; Hornok S
[Ad] Endereço:1 Department of Parasitology and Zoology, University of Veterinary Medicine , István u. 2, H-1078 Budapest , Hungary.
[Ti] Título:DNA of free-living bodonids (Euglenozoa: Kinetoplastea) in bat ectoparasites: potential relevance to the evolution of parasitic trypanosomatids.
[So] Source:Acta Vet Hung;65(4):531-540, 2017 12.
[Is] ISSN:0236-6290
[Cp] País de publicação:Hungary
[La] Idioma:eng
[Ab] Resumo:Kinetoplastids are flagellated protozoa, including principally free-living bodonids and exclusively parasitic trypanosomatids. In the most species-rich genus, Trypanosoma, more than thirty species were found to infect bats worldwide. Bat trypanosomes are also known to have played a significant role in the evolution of T. cruzi, a species with high veterinary medical significance. Although preliminary data attested the occurrence of bat trypanosomes in Hungary, these were never sought for with molecular methods. Therefore, amplification of an approx. 900-bp fragment of the 18S rRNA gene of kinetoplastids was attempted from 307 ixodid and 299 argasid ticks collected from bats, and from 207 cimicid bugs collected from or near bats in Hungary and Romania. Three samples, one per each bat ectoparasite group, were PCR positive. Sequencing revealed the presence of DNA from free-living bodonids (Bodo saltans and neobodonids), but no trypanosomes were detected. The most likely source of bodonid DNA detected here in engorged bat ectoparasites is the blood of their bat hosts. However, how bodonids were acquired by bats, can only be speculated. Bats are known to drink from freshwater bodies, i.e. the natural habitats of B. saltans and related species, allowing bats to ingest bodonids. Consequently, these results suggest that at least the DNA of bodonids might pass through the alimentary mucosa of bats into their circulation. The above findings highlight the importance of studying bats and other mammals for the occurrence of bodonids in their blood and excreta, with potential relevance to the evolution of free-living kinetoplastids towards parasitism.
[Mh] Termos MeSH primário: Evolução Biológica
Quirópteros/parasitologia
DNA/genética
Ectoparasitoses/veterinária
Euglenozoários/genética
Trypanosomatina/genética
[Mh] Termos MeSH secundário: Animais
Cimicidae/parasitologia
Ectoparasitoses/parasitologia
Filogeografia
Carrapatos/parasitologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
9007-49-2 (DNA)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171220
[St] Status:MEDLINE
[do] DOI:10.1556/004.2017.051


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Texto completo SciELO Brasil
[PMID]:29211107
[Au] Autor:Lopes CMT; Menna-Barreto RFS; Pavan MG; Pereira MCS; Roque ALR
[Ad] Endereço:Fundação Oswaldo Cruz-Fiocruz, Instituto Oswaldo Cruz, Laboratório de Biologia de Tripanosomatídeos, Rio de Janeiro, RJ, Brasil.
[Ti] Título:Trypanosoma janseni n. sp. (Trypanosomatida: Trypanosomatidae) isolated from Didelphis aurita (Mammalia: Didelphidae) in the Atlantic Rainforest of Rio de Janeiro, Brazil: integrative taxonomy and phylogeography within the Trypanosoma cruzi clade.
[So] Source:Mem Inst Oswaldo Cruz;113(1):45-55, 2018 Jan.
[Is] ISSN:1678-8060
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Didelphis spp. are a South American marsupial species that are among the most ancient hosts for the Trypanosoma spp. OBJECTIVES: We characterise a new species (Trypanosoma janseni n. sp.) isolated from the spleen and liver tissues of Didelphis aurita in the Atlantic Rainforest of Rio de Janeiro, Brazil. METHODS: The parasites were isolated and a growth curve was performed in NNN and Schneider's media containing 10% foetal bovine serum. Parasite morphology was evaluated via light microscopy on Giemsa-stained culture smears, as well as scanning and transmission electron microscopy. Molecular taxonomy was based on a partial region (737-bp) of the small subunit (18S) ribosomal RNA gene and 708 bp of the nuclear marker, glycosomal glyceraldehyde-3-phosphate dehydrogenase (gGAPDH) genes. Maximum likelihood and Bayesian inference methods were used to perform a species coalescent analysis and to generate individual and concatenated gene trees. Divergence times among species that belong to the T. cruzi clade were also inferred. FINDINGS: In vitro growth curves demonstrated a very short log phase, achieving a maximum growth rate at day 3 followed by a sharp decline. Only epimastigote forms were observed under light and scanning microscopy. Transmission electron microscopy analysis showed structures typical to Trypanosoma spp., except one structure that presented as single-membraned, usually grouped in stacks of three or four. Phylogeography analyses confirmed the distinct species status of T. janseni n. sp. within the T. cruzi clade. Trypanosoma janseni n. sp. clusters with T. wauwau in a well-supported clade, which is exclusive and monophyletic. The separation of the South American T. wauwau + T. janseni coincides with the separation of the Southern Super Continent. CONCLUSIONS: This clade is a sister group of the trypanosomes found in Australian marsupials and its discovery sheds light on the initial diversification process based on what we currently know about the T. cruzi clade.
[Mh] Termos MeSH primário: DNA de Protozoário/genética
Didelphis/parasitologia
RNA Ribossômico 18S/genética
Trypanosomatina/genética
[Mh] Termos MeSH secundário: Animais
Brasil
Filogeografia
Reação em Cadeia da Polimerase
Floresta Úmida
Trypanosoma cruzi
Trypanosomatina/classificação
Trypanosomatina/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Protozoan); 0 (RNA, Ribosomal, 18S)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180131
[Lr] Data última revisão:
180131
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171207
[St] Status:MEDLINE


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[PMID]:28939968
[Au] Autor:Sukla S; Roy S; Sundar S; Biswas S
[Ad] Endereço:Indian Institute of Chemical Biology (CSIR), Kolkata, West Bengal, 700032, India.
[Ti] Título:Leptomonas seymouri narna-like virus 1 and not leishmaniaviruses detected in kala-azar samples from India.
[So] Source:Arch Virol;162(12):3827-3835, 2017 Dec.
[Is] ISSN:1432-8798
[Cp] País de publicação:Austria
[La] Idioma:eng
[Ab] Resumo:The great majority of kala-azar/visceral leishmaniasis (VL) cases, which are caused by Leishmania donovani (LD), are reported in Asia. We investigated whether leishmaniaviruses (LRVs) are present in LD isolates. These dsRNA viruses contribute to hyperpathogenicity, as observed in the case of other members of the genus Leishmania. However, LRVs could not be detected in 22 Indian LD isolates tested in the present study, while 70% of these original LD isolates harboured a virus that was not of LD but instead of Leptomonas seymouri (LS) origin. LS is another protozoon that parasitizes the sandfly vector of LD. Historically, LD clinical isolates from India often showed high incidence of LS coinfection. LS was detected in 20 out of the 22 (91%) above-mentioned LD isolates. Leptomonas seymouri narna-like virus 1 (Lepsey NLV1) was identified by whole-genome sequencing in an LD-LS coinfected sample, and its presence was confirmed by PCR and sequencing in 15 (75%) of the 20 LD-LS coinfected samples. The LS-negative LD samples were also virus negative by PCR. That the human host is exposed to an RNA virus in LS, another coinfecting parasite with LD, i.e., the "LD-LS-Lepsey NLV1 triple pathogen" phenomenon, unveils a new paradigm of research towards revisiting the mysteries of Indian leishmaniasis pathogenesis and management.
[Mh] Termos MeSH primário: Leishmaniose Visceral/patologia
Leishmaniose Visceral/parasitologia
Vírus de RNA/classificação
Vírus de RNA/isolamento & purificação
Trypanosomatina/isolamento & purificação
Trypanosomatina/virologia
[Mh] Termos MeSH secundário: Genoma Viral
Seres Humanos
Índia
Leishmania donovani/isolamento & purificação
Leishmania donovani/virologia
Reação em Cadeia da Polimerase
Vírus de RNA/genética
Análise de Sequência de DNA
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170924
[St] Status:MEDLINE
[do] DOI:10.1007/s00705-017-3559-y


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[PMID]:28601067
[Au] Autor:Gerasimov ES; Gasparyan AA; Litus IA; Logacheva MD; Kolesnikov AA
[Ad] Endereço:Lomonosov Moscow State University, Faculty of Biology, Moscow, 119991, Russia. aak330@ynadex.ru.
[Ti] Título:Minicircle Kinetoplast Genome of Insect Trypanosomatid Leptomonas pyrrhocoris.
[So] Source:Biochemistry (Mosc);82(5):572-578, 2017 May.
[Is] ISSN:1608-3040
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We present here the structure of a minicircle population based on transcriptome sequencing of Leptomonas pyrrhocoris. We show that minicircle DNA molecules are dimeric. As in dixenous species, the entire molecule of minicircle DNA is transcribed. This is the first minicircle transcriptome of monoxenous trypanosomatid species determined using NGS technology.
[Mh] Termos MeSH primário: DNA de Cinetoplasto/genética
Genoma de Protozoário
Transcriptoma
Trypanosomatina/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Kinetoplast)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170621
[Lr] Data última revisão:
170621
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170612
[St] Status:MEDLINE
[do] DOI:10.1134/S0006297917050054


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[PMID]:28587841
[Au] Autor:Freitas-Mesquita AL; Meyer-Fernandes JR
[Ad] Endereço:Instituto de Bioquímica Médica Leopoldo de Meis, Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro, Rio de Janeiro, 21941-590, Brazil. Electronic address: anitaleocadio2@gmail.com.
[Ti] Título:3'nucleotidase/nuclease in protozoan parasites: Molecular and biochemical properties and physiological roles.
[So] Source:Exp Parasitol;179:1-6, 2017 Aug.
[Is] ISSN:1090-2449
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:3'-nucleotidase/nuclease (3'NT/NU) is a bi-functional enzyme that is able to hydrolyze 3'-monophosphorylated nucleotides and nucleic acids. This review summarizes the major molecular and biochemical properties of this enzyme in different trypanosomatid species. Sequence analysis of the gene encoding 3'NT/NU in Leishmania and Crithidia species showed that the protein possesses five highly conserved regions that are characteristic of members of the class I nuclease family. 3'NT/NU presents a molecular weight of approximately 40 kDa, which is conserved among the studied species. Throughout the review, we discuss inhibitors and substrate specificity, relating them to the putative structure of the enzyme. Finally, we present the major biological roles performed by 3'NT/NU. The involvement of 3'NT/NU in the purine salvage pathway was confirmed by the increase of activity and expression of the enzyme when the parasites were submitted to purine starvation. The generation of extracellular adenosine is also important to the modulation of the host immune response. Interaction assays involving Leishmania parasites and macrophages indicated that 3'-nucleotidase activity increases the association index between them. Recently, it was shown that 3'NT/NU plays a role in parasite escape from neutrophil extracellular traps, one of the first mechanisms of the host immune system for preventing infection.
[Mh] Termos MeSH primário: Nucleotidases/metabolismo
Trypanosomatina/enzimologia
[Mh] Termos MeSH secundário: Interações Hospedeiro-Parasita
Concentração de Íons de Hidrogênio
Macrófagos/parasitologia
Nucleotidases/antagonistas & inibidores
Nucleotidases/química
Nucleotidases/genética
Especificidade por Substrato
Trypanosomatina/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
EC 3.1.3.- (Nucleotidases)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170726
[Lr] Data última revisão:
170726
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170608
[St] Status:MEDLINE


  6 / 745 MEDLINE  
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Umezawa, Eufrosina Setsu
Texto completo SciELO Brasil
[PMID]:28380110
[Au] Autor:Kesper N; Teixeira MM; Lindoso JA; Barbieri CL; Umezawa ES
[Ad] Endereço:Universidade de São Paulo, Instituto de Medicina Tropical de São Paulo, São Paulo, Brazil.
[Ti] Título:Leptomonas seymouri and Crithidia fasciculata exoantigens can discriminate human cases of visceral leishmaniasis from American tegumentary leishmaniasis ones.
[So] Source:Rev Inst Med Trop Sao Paulo;59:e1, 2017 Apr 03.
[Is] ISSN:1678-9946
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:Exoantigens (exo) from Leptomonas seymouri and Crithidia fasciculata were used in an enzyme linked immunosorbent assay (ELISA), showing 100% reactivity with sera from visceral leishmaniasis (VL) cases, and no reactivity with American tegumentary leishmaniasis (ATL) ones. Our results have indicated that these exoantigens can be applied in the discrimination of VL and ATL cases.
[Mh] Termos MeSH primário: Antígenos de Protozoários/sangue
Crithidia fasciculata/imunologia
Leishmania donovani/imunologia
Leishmaniose Cutânea/diagnóstico
Leishmaniose Visceral/diagnóstico
Trypanosomatina/imunologia
[Mh] Termos MeSH secundário: Anticorpos Antiprotozoários/sangue
Reações Cruzadas
Ensaio de Imunoadsorção Enzimática
Seres Humanos
Imunoglobulina G/sangue
Leishmaniose Cutânea/parasitologia
Leishmaniose Visceral/parasitologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Protozoan); 0 (Antigens, Protozoan); 0 (Immunoglobulin G)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170601
[Lr] Data última revisão:
170601
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170406
[St] Status:MEDLINE


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[PMID]:28210761
[Au] Autor:Matveyev AV; Alves JM; Serrano MG; Lee V; Lara AM; Barton WA; Costa-Martins AG; Beverley SM; Camargo EP; Teixeira MM; Buck GA
[Ad] Endereço:Department of Microbiology and Immunology and the Center for the Study of Biological Complexity, Virginia Commonwealth University, Richmond, VA, USA. Andrey.Matveyev@VCUhealth.org.
[Ti] Título:The Evolutionary Loss of RNAi Key Determinants in Kinetoplastids as a Multiple Sporadic Phenomenon.
[So] Source:J Mol Evol;84(2-3):104-115, 2017 Mar.
[Is] ISSN:1432-1432
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:We screened the genomes of a broad panel of kinetoplastid protists for genes encoding proteins associated with the RNA interference (RNAi) system using probes from the Argonaute (AGO1), Dicer1 (DCL1), and Dicer2 (DCL2) genes of Leishmania brasiliensis and Crithidia fasciculata. We identified homologs for all the three of these genes in the genomes of a subset of these organisms. However, several of these organisms lacked evidence for any of these genes, while others lacked only DCL2. The open reading frames encoding these putative proteins were structurally analyzed in silico. The alignments indicated that the genes are homologous with a high degree of confidence, and three-dimensional structural models strongly supported a functional relationship to previously characterized AGO1, DCL1, and DCL2 proteins. Phylogenetic analysis of these putative proteins showed that these genes, when present, evolved in parallel with other nuclear genes, arguing that the RNAi system genes share a common progenitor, likely across all Kinetoplastea. In addition, the genome segments bearing these genes are highly conserved and syntenic, even among those taxa in which they are absent. However, taxa in which these genes are apparently absent represent several widely divergent branches of kinetoplastids, arguing that these genes were independently lost at least six times in the evolutionary history of these organisms. The mechanisms responsible for the apparent coordinate loss of these RNAi system genes independently in several lineages of kinetoplastids, while being maintained in other related lineages, are currently unknown.
[Mh] Termos MeSH primário: Crithidia fasciculata/genética
DNA de Cinetoplasto/genética
Leishmania braziliensis/genética
Trypanosomatina/genética
[Mh] Termos MeSH secundário: Sequência de Aminoácidos/genética
Proteínas Argonauta/genética
Evolução Biológica
DNA de Cinetoplasto/metabolismo
Eucariotos/genética
Evolução Molecular
Genoma/genética
Filogenia
Interferência de RNA/fisiologia
Ribonuclease III/genética
Alinhamento de Sequência/métodos
Sintenia/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Argonaute Proteins); 0 (DNA, Kinetoplast); EC 3.1.26.3 (Ribonuclease III)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170218
[St] Status:MEDLINE
[do] DOI:10.1007/s00239-017-9780-1


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[PMID]:28158179
[Au] Autor:Gazestani VH; Yip CW; Nikpour N; Berghuis N; Salavati R
[Ad] Endereço:Institute of Parasitology, McGill University, Ste. Anne de Bellevue, Quebec, Canada.
[Ti] Título:TrypsNetDB: An integrated framework for the functional characterization of trypanosomatid proteins.
[So] Source:PLoS Negl Trop Dis;11(2):e0005368, 2017 Feb.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Trypanosomatid parasites cause serious infections in humans and production losses in livestock. Due to the high divergence from other eukaryotes, such as humans and model organisms, the functional roles of many trypanosomatid proteins cannot be predicted by homology-based methods, rendering a significant portion of their proteins as uncharacterized. Recent technological advances have led to the availability of multiple systematic and genome-wide datasets on trypanosomatid parasites that are informative regarding the biological role(s) of their proteins. Here, we report TrypsNetDB (http://trypsNetDB.org), a web-based resource for the functional annotation of 16 different species/strains of trypanosomatid parasites. The database not only visualizes the network context of the queried protein(s) in an intuitive way but also examines the response of the represented network in more than 50 different biological contexts and its enrichment for various biological terms and pathways, protein sequence signatures, and potential RNA regulatory elements. The interactome core of the database, as of Jan 23, 2017, contains 101,187 interactions among 13,395 trypanosomatid proteins inferred from 97 genome-wide and focused studies on the interactome of these organisms.
[Mh] Termos MeSH primário: Biologia Computacional/métodos
Bases de Dados Genéticas
Proteínas de Protozoários/genética
Proteínas de Protozoários/metabolismo
Trypanosomatina/genética
[Mh] Termos MeSH secundário: Anotação de Sequência Molecular
Mapas de Interação de Proteínas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Protozoan Proteins)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170619
[Lr] Data última revisão:
170619
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170204
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0005368


  9 / 745 MEDLINE  
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[PMID]:28073072
[Au] Autor:Frolov AO; Malysheva MN; Ganyukova AI; Yurchenko V; Kostygov AY
[Ad] Endereço:Zoological Institute of the Russian Academy of Sciences, Universitetskaya nab. 1, St. Petersburg 199034, Russia.
[Ti] Título:Life cycle of Blastocrithidia papi sp. n. (Kinetoplastea, Trypanosomatidae) in Pyrrhocoris apterus (Hemiptera, Pyrrhocoridae).
[So] Source:Eur J Protistol;57:85-98, 2017 Feb.
[Is] ISSN:1618-0429
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Blastocrithidia papi sp. n. is a cyst-forming trypanosomatid parasitizing firebugs (Pyrrhocoris apterus). It is a member of the Blastocrithidia clade and a very close relative of B. largi, to which it is almost identical through its SSU rRNA gene sequence. However, considering the SL RNA gene these two species represent quite distinct, not even related typing units. Morphological analysis of the new species revealed peculiar or even unique features, which may be useful for future taxonomic revision of the genus Blastocrithidia. These include a breach in the microtubular corset of rostrum at the site of contact with the flagellum, absence of desmosomes between flagellum and rostrum, large transparent vacuole near the flagellar pocket, and multiple vacuoles with fibrous content in the posterior portion of the cell. The study of the flagellates' behavior in the host intestine revealed that they may attach both to microvilli of enterocytes using swollen flagellar tip and to extracellular membranes layers using hemidesmosomes of flagellum. Laboratory experiments on B. papi transmission in P. apterus demonstrated that the parasite may be transmitted vertically (via contaminated surface of eggs) and horizontally (via contaminated substrate and/or necrophagy). We argue that the parasite exploits transmission mechanisms intended for obligate bacterial symbionts of P. apterus.
[Mh] Termos MeSH primário: Heterópteros/parasitologia
Estágios do Ciclo de Vida
Trypanosomatina/citologia
Trypanosomatina/fisiologia
[Mh] Termos MeSH secundário: Animais
Heterópteros/microbiologia
Intestinos/parasitologia
Trypanosomatina/classificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170407
[Lr] Data última revisão:
170407
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170111
[St] Status:MEDLINE


  10 / 745 MEDLINE  
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[PMID]:28064141
[Au] Autor:Borsari C; Santarem N; Torrado J; Olías AI; Corral MJ; Baptista C; Gul S; Wolf M; Kuzikov M; Ellinger B; Witt G; Gribbon P; Reinshagen J; Linciano P; Tait A; Costantino L; Freitas-Junior LH; Moraes CB; Bruno Dos Santos P; Alcântara LM; Franco CH; Bertolacini CD; Fontana V; Tejera Nevado P; Clos J; Alunda JM; Cordeiro-da-Silva A; Ferrari S; Costi MP
[Ad] Endereço:University of Modena and Reggio Emilia, Via Campi 103, 41125, Modena, Italy.
[Ti] Título:Methoxylated 2'-hydroxychalcones as antiparasitic hit compounds.
[So] Source:Eur J Med Chem;126:1129-1135, 2017 Jan 27.
[Is] ISSN:1768-3254
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:Chalcones display a broad spectrum of pharmacological activities. Herein, a series of 2'-hydroxy methoxylated chalcones was synthesized and evaluated towards Trypanosoma brucei, Trypanosoma cruzi and Leishmania infantum. Among the synthesized library, compounds 1, 3, 4, 7 and 8 were the most potent and selective anti-T. brucei compounds (EC = 1.3-4.2 µM, selectivity index >10-fold). Compound 4 showed the best early-tox and antiparasitic profile. The pharmacokinetic studies of compound 4 in BALB/c mice using hydroxypropil-ß-cyclodextrins formulation showed a 7.5 times increase in oral bioavailability.
[Mh] Termos MeSH primário: Antiparasitários/química
Antiparasitários/farmacologia
Chalconas/química
Chalconas/farmacologia
[Mh] Termos MeSH secundário: Animais
Antiparasitários/farmacocinética
Antiparasitários/toxicidade
Linhagem Celular Tumoral
Chalconas/farmacocinética
Chalconas/toxicidade
Ciclodextrinas/química
Portadores de Fármacos/química
Camundongos
Solubilidade
Trypanosomatina/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antiparasitic Agents); 0 (Chalcones); 0 (Cyclodextrins); 0 (Drug Carriers); VY06DZ94OC (2'-hydroxychalcone)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170109
[St] Status:MEDLINE



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