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  1 / 22 MEDLINE  
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[PMID]:29353723
[Au] Autor:Wu YZ; Zhang HW; Sun ZH; Dai JG; Hu YC; Li R; Lin PC; Xia GY; Wang LY; Qiu BL; Zhang JF; Ge GB; Lin S
[Ad] Endereço:State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
[Ti] Título:Bysspectin A, an unusual octaketide dimer and the precursor derivatives from the endophytic fungus Byssochlamys spectabilis IMM0002 and their biological activities.
[So] Source:Eur J Med Chem;145:717-725, 2018 Feb 10.
[Is] ISSN:1768-3254
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:Bysspectin A (1), a polyketide-derived octaketide dimer with a novel carbon skeleton, and two new precursor derivatives, bysspectins B and C (2 and 3), were obtained from an organic extract of the endophytic fungus Byssochlamys spectabilis that had been isolated from a leaf tissue of the traditional Chinese medicinal plant Edgeworthia chrysantha, together with a known octaketide, paecilocin A (4). Their structures were determined by HRMS, 1D and 2D NMR spectroscopic analysis. A plausible route for their biosynthetic pathway is proposed. Compounds 1-3 were tested for their antimicrobial activities. Only compound 3 was weakly active against Escherichia coli and Staphyloccocus aureus with MIC values of 32 and 64 µg/mL, respectively. Further, the inhibitory effects on human carboxylesterases (hCE1, hCE2) of compounds 1 and 4 were evaluated. The results demonstrated that bysspectin A (1) was a novel and highly selective inhibitor against hCE2 with the IC value of 2.01 µM. Docking simulation also demonstrated that active compound 1 created interaction with the Ser-288 (the catalytic amino-acid in the catalytic cavity) of hCE2 via hydrogen bonding, revealing its highly selective inhibition toward hCE2.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Byssochlamys/química
Carboxilesterase/antagonistas & inibidores
Hidrolases de Éster Carboxílico/antagonistas & inibidores
Inibidores Enzimáticos/farmacologia
Escherichia coli/efeitos dos fármacos
Policetídeos/farmacologia
Staphylococcus aureus/efeitos dos fármacos
[Mh] Termos MeSH secundário: Antibacterianos/química
Antibacterianos/isolamento & purificação
Biocatálise
Carboxilesterase/metabolismo
Hidrolases de Éster Carboxílico/metabolismo
Dimerização
Relação Dose-Resposta a Droga
Inibidores Enzimáticos/química
Inibidores Enzimáticos/isolamento & purificação
Seres Humanos
Testes de Sensibilidade Microbiana
Simulação de Acoplamento Molecular
Estrutura Molecular
Policetídeos/química
Policetídeos/isolamento & purificação
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Enzyme Inhibitors); 0 (Polyketides); 0 (bysspectin A); EC 3.1.1.- (Carboxylic Ester Hydrolases); EC 3.1.1.1 (CES1 protein, human); EC 3.1.1.1 (CES2 protein, human); EC 3.1.1.1 (Carboxylesterase)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180123
[St] Status:MEDLINE


  2 / 22 MEDLINE  
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[PMID]:27684593
[Au] Autor:Hechmi N; Bosso L; El-Bassi L; Scelza R; Testa A; Jedidi N; Rao MA
[Ad] Endereço:Laboratory of Wastewater Treatment, Water Researches and Technologies Centre (CERTE), Technopole Borj Cedria BP 273, Soliman, 8020, Tunisia; National Agronomic Institute of Tunisia, 43, Avenue Charles Nicolle, 1082, Tunis-Mahrajène, Tunisia.
[Ti] Título:Depletion of pentachlorophenol in soil microcosms with Byssochlamys nivea and Scopulariopsis brumptii as detoxification agents.
[So] Source:Chemosphere;165:547-554, 2016 Dec.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Pentachlorophenol (PCP) is a toxic compound which is widely used as a wood preservative product and general biocide. It is persistent in the environment and has been classified as a persistent organic pollutant to be reclaimed in many countries. Fungal bioremediation is an emerging approach to rehabilitating areas fouled by recalcitrant xenobiotics. In the present study, we isolated two fungal strains from an artificially PCP-contaminated soil during a long-term bioremediation study and evaluated their potential as bioremediation agents in depletion and detoxification of PCP in soil microcosms. The two fungal strains were identified as: Byssochlamys nivea (Westling, 1909) and Scopulariopsis brumptii (Salvanet-Duval, 1935). PCP removal and toxicity were examined during 28 days of incubation. Bioaugmented microcosms revealed a 60% and 62% PCP removal by B. nivea and S. brumptii, respectively. Co-inoculation of B. nivea and S. brumptii showed a synergetic effect on PCP removal resulting in 95% and 80% PCP decrease when initial concentrations were 12.5 and 25 mg kg , respectively. Detoxification in bioaugmented soil and the efficient role of fungi in the rehabilitation of PCP contaminated soil were experimentally proven by toxicity assays. A decrease in inhibition of bioluminescence of Escherichia coli HB101 pUCD607 and an increase of germination index of mustard (Brassica alba) seeds were observed in the decontaminated soils.
[Mh] Termos MeSH primário: Byssochlamys/metabolismo
Pentaclorofenol/metabolismo
Scopulariopsis/metabolismo
Poluentes do Solo/metabolismo
[Mh] Termos MeSH secundário: Biodegradação Ambiental
Escherichia coli/efeitos dos fármacos
Escherichia coli/metabolismo
Germinação/efeitos dos fármacos
Luminescência
Pentaclorofenol/toxicidade
Sinapis/efeitos dos fármacos
Sinapis/crescimento & desenvolvimento
Microbiologia do Solo
Poluentes do Solo/toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Soil Pollutants); D9BSU0SE4T (Pentachlorophenol)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:171008
[Lr] Data última revisão:
171008
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160930
[St] Status:MEDLINE


  3 / 22 MEDLINE  
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[PMID]:27190291
[Au] Autor:Khiralla A; Mohamed IE; Tzanova T; Schohn H; Slezack-Deschaumes S; Hehn A; André P; Carre G; Spina R; Lobstein A; Yagi S; Laurain-Mattar D
[Ad] Endereço:Université de Lorraine, SRSMC, UMR 7565, BP 70239, F-54506 VandÅ“uvre-lès-Nancy, France CNRS, SRSMC, UMR 7565, BP 70239, F-54506 VandÅ“uvre-lès-Nancy, France.
[Ti] Título:Endophytic fungi associated with Sudanese medicinal plants show cytotoxic and antibiotic potential.
[So] Source:FEMS Microbiol Lett;363(11), 2016 06.
[Is] ISSN:1574-6968
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In this study, we isolated 15 endophytic fungi from five Sudanese medicinal plants. Each fungal endophytic strain was identified by sequencing of internal transcribed spacer (ITS) regions of rDNA. Ethyl acetate extracts were prepared from each endophyte cultivated in vitro and tested for their respective antibacterial activities and antiproliferative activities against human cancer cells. Antibacterial screening was carried out against two bacterial strains: Gram-negative Escherichia coli and Gram-positive methicillin-resistant Staphylococcus aureus, by the broth dilution method. Cell viability was evaluated by the MTT procedure after exposure of MCF7 breast cancer cells and HT29 or HCT116 human colon adenocarcinoma cells to each endophytic extract. Of interest, Byssochlamys spectabilis isolated from Euphorbia prostata showed cytotoxicity (IC50 = 1.51 ± 0.2 µg mL(-1)) against MCF7 cells, but had a low effect against HT29 or HCT116 cells (IC50 > 20 µg mL(-1)). Cladosporium cladosporioides 2, isolated from Vernonia amygdalina leaves, showed antiproliferative activities against MCF7 cells (IC50 = 10.5 ± 1.5 µg mL(-1)) only. On the other hand, B. spectabilis and Alternaria sp. extract had antibacterial activities against the S. aureus strain. The findings of this work revealed that endophytic fungi associated with medicinal plants from Sudan could be considered as an attractive source of new therapeutic compounds.
[Mh] Termos MeSH primário: Antibacterianos/isolamento & purificação
Antibacterianos/farmacologia
Citotoxinas/isolamento & purificação
Citotoxinas/farmacologia
Endófitos/química
Fungos/química
Plantas Medicinais/microbiologia
[Mh] Termos MeSH secundário: Acetatos/química
Alternaria/química
Byssochlamys/química
Byssochlamys/isolamento & purificação
Linhagem Celular Tumoral
Proliferação Celular/efeitos dos fármacos
Sobrevivência Celular/efeitos dos fármacos
Cladosporium/química
Cladosporium/isolamento & purificação
DNA Ribossômico/genética
Endófitos/genética
Endófitos/crescimento & desenvolvimento
Endófitos/isolamento & purificação
Escherichia coli/efeitos dos fármacos
Euphorbia/microbiologia
Fungos/genética
Fungos/isolamento & purificação
Seres Humanos
Concentração Inibidora 50
Staphylococcus aureus Resistente à Meticilina/efeitos dos fármacos
Testes de Sensibilidade Microbiana
Folhas de Planta/microbiologia
Sudão
Vernonia/microbiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Acetates); 0 (Anti-Bacterial Agents); 0 (Cytotoxins); 0 (DNA, Ribosomal); 76845O8NMZ (ethyl acetate)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171126
[Lr] Data última revisão:
171126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160519
[St] Status:MEDLINE


  4 / 22 MEDLINE  
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[PMID]:27020163
[Au] Autor:Bosso L; Scelza R; Varlese R; Meca G; Testa A; Rao MA; Cristinzio G
[Ad] Endereço:Department of Agriculture, University of Naples Federico II, via Università n. 100, 80055 Portici (Naples), Italy. Electronic address: luciano.bosso@unina.it.
[Ti] Título:Assessing the effectiveness of Byssochlamys nivea and Scopulariopsis brumptii in pentachlorophenol removal and biological control of two Phytophthora species.
[So] Source:Fungal Biol;120(4):645-653, 2016 Apr.
[Is] ISSN:1878-6146
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Bioremediation and biological-control by fungi have made tremendous strides in numerous biotechnology applications. The aim of this study was to test Byssochlamys nivea and Scopulariopsis brumptii in sensitivity and degradation to pentachlorophenol (PCP) and in biological-control of Phytophthora cinnamomi and Phytophthora cambivora. B. nivea and S. brumptii were tested in PCP sensitivity and degradation in microbiological media while the experiments of biological-control were carried out in microbiological media and soil. The fungal strains showed low PCP sensitivity at 12.5 and 25 mg PCP L(-1) although the hyphal size, fungal mat, patulin, and spore production decreased with increasing PCP concentrations. B. nivea and S. brumptii depleted completely 12.5 and 25 mg PCP L(-1) in liquid culture after 28 d of incubation at 28 °C. Electrolyte leakage assays showed that both fungi have low sensitivity to 25 mg PCP L(-1) and produced no toxic compounds for the plant. B. nivea and S. brumptii were able to inhibit the growth of the two plant pathogens in laboratory studies and reduce the mortality of chestnut plants caused by two Phytophthorae in greenhouse experiments. The two fungal strains did not produce volatile organic compounds able to reduce the growth of two plant pathogens tested.
[Mh] Termos MeSH primário: Byssochlamys/fisiologia
Poluentes Ambientais/metabolismo
Pentaclorofenol/metabolismo
Phytophthora/crescimento & desenvolvimento
Scopulariopsis/fisiologia
[Mh] Termos MeSH secundário: Byssochlamys/efeitos dos fármacos
Fagaceae/microbiologia
Interações Microbianas
Testes de Sensibilidade Microbiana
Controle Biológico de Vetores
Doenças das Plantas/microbiologia
Doenças das Plantas/prevenção & controle
Scopulariopsis/efeitos dos fármacos
Análise de Sobrevida
Temperatura Ambiente
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Environmental Pollutants); D9BSU0SE4T (Pentachlorophenol)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:170901
[Lr] Data última revisão:
170901
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160330
[St] Status:MEDLINE


  5 / 22 MEDLINE  
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Texto completo SciELO Brasil
[PMID]:26602345
[Au] Autor:Zawadneak MA; Pimentel IC; Robl D; Dalzoto P; Vicente V; Sosa-Gómez DR; Porsani M; Cuquel FL
[Ad] Endereço:Departamento de Patologia Básica, Universidade Federal do Paraná, Curitiba, PR, Brazil.
[Ti] Título:Paecilomyces niveus Stolk & Samson, 1971 (Ascomycota: Thermoascaceae) as a pathogen of Nasonovia ribisnigri (Mosley, 1841) (Hemiptera, Aphididae) in Brazil.
[So] Source:Braz J Biol;75(4 Suppl 1):S158-62, 2015 Nov.
[Is] ISSN:1678-4375
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:Nasonovia ribisnigri is a key pest of lettuce (Lactuca sativa L.) in Brazil that requires alternative control methods to synthetic pesticides. We report, for the first time, the occurrence of Paecilomyces niveus as an entomopathogen of the aphid Nasonovia ribisnigri in Pinhais, Paraná, Brazil. Samples of mummified aphids were collected from lettuce crops. The fungus P. niveus (PaePR) was isolated from the insect bodies and identified by macro and micromorphology. The species was confirmed by sequencing Internal Transcribed Spacer (ITS) rDNA. We obtained a sequence of 528 bp (accession number HQ441751), which aligned with Byssochlamys nivea strains (100% identities). In a bioassay, 120 h after inoculation of N. ribisnigri with pathogenic P. niveus had an average mortality of 74%. The presence of P. niveus as a natural pathogen of N. ribisnigri in Brazil suggests that it may be possible to employ P. niveus to minimize the use of chemical insecticides.
[Mh] Termos MeSH primário: Afídeos/microbiologia
Paecilomyces/fisiologia
[Mh] Termos MeSH secundário: Animais
Afídeos/crescimento & desenvolvimento
Brasil
Byssochlamys/classificação
Byssochlamys/isolamento & purificação
Byssochlamys/fisiologia
DNA Fúngico
Dados de Sequência Molecular
Ninfa/crescimento & desenvolvimento
Ninfa/microbiologia
Paecilomyces/classificação
Paecilomyces/isolamento & purificação
RNA Ribossômico 18S
Análise de Sequência de DNA
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Fungal); 0 (RNA, Ribosomal, 18S)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:151218
[Lr] Data última revisão:
151218
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151126
[St] Status:MEDLINE


  6 / 22 MEDLINE  
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[PMID]:26452099
[Au] Autor:Szwalbe AJ; Williams K; O'Flynn DE; Bailey AM; Mulholland NP; Vincent JL; Willis CL; Cox RJ; Simpson TJ
[Ad] Endereço:School of Chemistry, Bristol University, Cantock's Close, Bristol, BS8 1TS, UK.
[Ti] Título:Novel nonadride, heptadride and maleic acid metabolites from the byssochlamic acid producer Byssochlamys fulva IMI 40021 - an insight into the biosynthesis of maleidrides.
[So] Source:Chem Commun (Camb);51(96):17088-91, 2015 Dec 14.
[Is] ISSN:1364-548X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The filamentous fungus Byssochlamys fulva strain IMI 40021 produces (+)-byssochlamic acid 1, its novel dihydroanalogue 2 and four related secondary metabolites. Agnestadrides A, 17 and B, 18 constitute a novel class of seven-membered ring, maleic anhydride-containing (hence termed heptadride) natural products. The putative maleic anhydride precursor 5 for both nonadride and heptadride biosynthesis was isolated as a fermentation product for the first time and its structure confirmed by synthesis. Acid 5 undergoes facile decarboxylation to anhydride 6. The generic term maleidrides is proposed to encompass biosynthetically-related compounds containing maleic anhydride moieties fused to an alicyclic ring, varying in size and substituents.
[Mh] Termos MeSH primário: Byssochlamys/metabolismo
Furanos/metabolismo
Maleatos/metabolismo
Anidridos Maleicos/metabolismo
[Mh] Termos MeSH secundário: Furanos/química
Maleatos/química
Anidridos Maleicos/química
Estrutura Molecular
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Furans); 0 (Maleates); 0 (Maleic Anhydrides); 743-51-1 (byssochlamic acid); 91XW058U2C (maleic acid)
[Em] Mês de entrada:1607
[Cu] Atualização por classe:161215
[Lr] Data última revisão:
161215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151010
[St] Status:MEDLINE
[do] DOI:10.1039/c5cc06988b


  7 / 22 MEDLINE  
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[PMID]:26408134
[Au] Autor:Manns DC; Churey JJ; Worobo RW
[Ad] Endereço:Department of Food Science, Cornell University, New York State Agricultural Experiment Station, Geneva, New York 14456, USA.
[Ti] Título:Variable Efficacy of the Proteinaceous Antifungal YvgO in Select Fruit Juices and Teas as a Complement with UV Methods of Food Protection.
[So] Source:J Food Prot;78(10):1851-60, 2015 Oct.
[Is] ISSN:1944-9097
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Heat-resistant fungal spores present a processing challenge for beverages and fruit juices, as thermal and UV strategies are often inadequate in reducing heat-resistant fungal burdens to acceptable levels. While effective against pathogenic or invasive bacteria, germicidal UV light treatments also fail to achieve an appreciable reduction of heat-resistant fungal spores. As an alternative, the efficacy of the antifungal protein YvgO was examined across a selection of fruit juices and teas, as well as solid model matrices. Compared with its efficacy in analogous liquid matrices, the apparent efficacy of YvgO was diminished on acidified solid matrices due to a reduction in YvgO diffusion. Using an XTT [2,3-bis(2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide] tetrazolium dye cytotoxicity assay, the effective concentrations to reduce growth by 50% were elucidated in samples challenged with Byssochlamys fulva H25. The MICs were determined and ranged from 2 ppm in apple juice and acidified teas to approximately 3 to 12 ppm for lemonade and orange, white cranberry, blueberry, prune, cherry, and grape juices. Apple cider and nonacidified teas showed reduced efficacy, with MICs exceeding 100 ppm. Tannin-rich products readily removed YvgO from the product, impairing its efficacy. Adding bovine serum albumin as a competitive inhibitor effectively reversed the YvgO-tannin association and restored efficacy in black but not green tea matrices. When challenged with a 5-log CFU inoculum of B. fulva, the shelf lives of the products were extended for various times up to 28 days in a concentrationdependent manner. However, initial efficacy was not predictive of shelf life extension, as some products exhibited improved protection at just two- and fourfold concentrations above the MIC, while others only exhibited long-term stability when concentrations exceeded 20 times the MIC. As such, YvgO may be an attractive alternative to currently available protection strategies and will provide needed diversity for natural food protectants.
[Mh] Termos MeSH primário: Antifúngicos/farmacologia
Contaminação de Alimentos/prevenção & controle
Irradiação de Alimentos
Sucos de Frutas e Vegetais/microbiologia
Chá/microbiologia
Raios Ultravioleta
[Mh] Termos MeSH secundário: Byssochlamys/efeitos dos fármacos
Byssochlamys/isolamento & purificação
Byssochlamys/efeitos da radiação
Eletroforese em Gel de Poliacrilamida
Microbiologia de Alimentos
Frutas/química
Frutas/microbiologia
Temperatura Alta
Concentração de Íons de Hidrogênio
Testes de Sensibilidade Microbiana
Esporos Fúngicos/efeitos dos fármacos
Esporos Fúngicos/isolamento & purificação
Esporos Fúngicos/efeitos da radiação
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (Tea)
[Em] Mês de entrada:1605
[Cu] Atualização por classe:150926
[Lr] Data última revisão:
150926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150927
[St] Status:MEDLINE
[do] DOI:10.4315/0362-028X.JFP-15-128


  8 / 22 MEDLINE  
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[PMID]:26280285
[Au] Autor:Evelyn; Silva FV
[Ad] Endereço:Department of Chemical and Materials Engineering, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand; Department of Chemical Engineering, University of Riau, Pekanbaru 28293, Indonesia.
[Ti] Título:Inactivation of Byssochlamys nivea ascospores in strawberry puree by high pressure, power ultrasound and thermal processing.
[So] Source:Int J Food Microbiol;214:129-36, 2015 Dec 02.
[Is] ISSN:1879-3460
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Byssochlamys nivea is a mold that can spoil processed fruit products and produce mycotoxins. In this work, high pressure processing (HPP, 600 MPa) and power ultrasound (24 kHz, 0.33 W/mL; TS) in combination with 75°C for the inactivation of four week old B. nivea ascospores in strawberry puree for up to 30 min was investigated and compared with 75°C thermal processing alone. TS and thermal processing can activate the mold ascospores, but HPP-75°C resulted in 2.0 log reductions after a 20 min process. For a 10 min process, HPP-75°C was better than 85°C alone in reducing B. nivea spores (1.4 vs. 0.2 log reduction), demonstrating that a lower temperature in combination with HPP is more effective for spore inactivation than heat alone at a higher temperature. The ascospore inactivation by HPP-thermal, TS and thermal processing was studied at different temperatures and modeled. Faster inactivation was achieved at higher temperatures for all the technologies tested, indicating the significant role of temperature in spore inactivation, alone or combined with other physical processes. The Weibull model described the spore inactivation by 600 MPa HPP-thermal (38, 50, 60, 75°C) and thermal (85, 90°C) processing, whereas the Lorentzian model was more appropriate for TS treatment (65, 70, 75°C). The models obtained provide a useful tool to design and predict pasteurization processes targeting B. nivea ascospores.
[Mh] Termos MeSH primário: Byssochlamys/crescimento & desenvolvimento
Fragaria/microbiologia
Ondas de Choque de Alta Energia
Pasteurização/métodos
Sonicação/métodos
Esporos Fúngicos/crescimento & desenvolvimento
[Mh] Termos MeSH secundário: Temperatura Baixa
Frutas/microbiologia
Temperatura Alta
Pressão
Ultrassom
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1605
[Cu] Atualização por classe:151016
[Lr] Data última revisão:
151016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150818
[St] Status:MEDLINE


  9 / 22 MEDLINE  
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[PMID]:25462919
[Au] Autor:Tremarin A; Longhi DA; Salomão Bde C; Aragão GM
[Ad] Endereço:Department of Chemical and Food Engineering, Federal University of Santa Catarina (UFSC), Florianópolis, SC, Brazil. Electronic address: andreiatremarin@gmail.com.
[Ti] Título:Modeling the growth of Byssochlamys fulva and Neosartorya fischeri on solidified apple juice by measuring colony diameter and ergosterol content.
[So] Source:Int J Food Microbiol;193:23-8, 2015 Jan 16.
[Is] ISSN:1879-3460
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Byssochlamys fulva and Neosartorya fischeri are heat-resistant fungi which are a concern to food industries (e.g. apple juice industry) since their growth represents significant economic liabilities. Although the most common method used to assess fungal growth in solid substrates is by measuring the colony's diameter, it is difficult to apply this method to food substrates. Alternatively, ergosterol contents have been used to quantify fungal contamination in some types of food. The current study aimed at modeling the growth of the heat-resistant fungi B. fulva and N. fischeri by measuring the colony diameter and ergosterol content, fitting the Baranyi and Roberts model to the results, and finally establishing a correlation between the parameters of the two analytical methods. Whereas the colony diameter was measured daily, the quantification of ergosterol was performed when the colonies reached diameters of 30, 60, 90, 120 and 150 mm. Results showed that B. fulva and N. fischeri were able to grow successfully on solidified apple juice at 10, 15, 20, 25 and 30 °C, and the Baranyi and Roberts model showed good ability to describe growth data. The correlation curves between the parameters of colony diameter and ergosterol content were obtained with satisfactory statistical indexes.
[Mh] Termos MeSH primário: Byssochlamys/química
Byssochlamys/crescimento & desenvolvimento
Ergosterol/análise
Microbiologia de Alimentos
Modelos Biológicos
Neosartorya/química
Neosartorya/crescimento & desenvolvimento
[Mh] Termos MeSH secundário: Aspergillus/crescimento & desenvolvimento
Bebidas/microbiologia
Malus/microbiologia
Temperatura Ambiente
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
Z30RAY509F (Ergosterol)
[Em] Mês de entrada:1503
[Cu] Atualização por classe:141216
[Lr] Data última revisão:
141216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141203
[St] Status:MEDLINE


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[PMID]:25217289
[Au] Autor:Manns DC; Churey JJ; Worobo RW
[Ad] Endereço:Department of Food Science, New York State Agricultural Experiment Station, Cornell University, 630 West North Street, Geneva, NY, 14456, USA, dcm38@cornell.edu.
[Ti] Título:Nutrient-Dependent Efficacy of the Antifungal Protein YvgO Correlates to Cellular Proliferation Rate in Candida albicans 3153A and Byssochlamys fulva H25.
[So] Source:Probiotics Antimicrob Proteins;6(3-4):198-207, 2014 Dec.
[Is] ISSN:1867-1314
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:YvgO is a recently characterized antifungal protein isolated from Bacillus thuringiensis SF361 that exhibits a broad spectrum of activity and pH stability. Customized colorimetric metabolic assays based on standard broth microdilution techniques were used to determine the variable tolerance of Byssochlamys fulva H25 and Candida albicans 3153A to YvgO exposure under select matrix conditions impacting cellular proliferation. Normalization of the solution pH after antifungal challenge expanded the available pH range under consideration allowing for a comprehensive in vitro assessment of YvgO efficacy. Indicator susceptibility was examined across an array of elementary growth-modifying conditions, including media pH, incubation temperature, ionic strength, and carbohydrate supplementation. Under suboptimal temperature and pH conditions, the indicator growth rate reduced, and YvgO-mediated susceptibility was attenuated. While YvgO association but not efficacy was somewhat influenced by solution ionic strength, carbohydrate supplementation was shown to be the most influential susceptibility factor, particularly for C. albicans. Although the specific choice of carbohydrate/nutrient supplement dictated the extent of enhanced YvgO efficacy, D-glucose additionally improved the association between antifungal and target. Indeed, when exposed to YvgO under conditions that lead to increased cellular proliferation, both indicators displayed a stronger association and susceptibility to YvgO when compared to carbohydrate-deprived media or suboptimal incubation environments. With further study, YvgO may have the capacity to function as a prophylaxis for food safety and preservation, as well as a pharmaceutical agent against opportunistic fungal pathogens either independently or in combination with other established treatments applied to both livestock and human health concerns.
[Mh] Termos MeSH primário: Bacillus thuringiensis/química
Proteínas de Bactérias/farmacologia
Byssochlamys/efeitos dos fármacos
Candida albicans/efeitos dos fármacos
Meios de Cultura/química
[Mh] Termos MeSH secundário: Bacillus thuringiensis/metabolismo
Proteínas de Bactérias/metabolismo
Byssochlamys/crescimento & desenvolvimento
Candida albicans/crescimento & desenvolvimento
Meios de Cultura/metabolismo
Glucose/metabolismo
Concentração de Íons de Hidrogênio
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (Bacterial Proteins); 0 (Culture Media); IY9XDZ35W2 (Glucose)
[Em] Mês de entrada:1607
[Cu] Atualização por classe:171110
[Lr] Data última revisão:
171110
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140914
[St] Status:MEDLINE
[do] DOI:10.1007/s12602-014-9167-1



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