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[PMID]: 28901763 [Au] Autor: He Y; Hu Z; Li Q; Huang J; Li XN; Zhu H; Liu J; Wang J; Xue Y; Zhang Y [Ad] Endereço: Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430030, People's Republic of China. [Ti] Título: Bioassay-Guided Isolation of Antibacterial Metabolites from Emericella sp. TJ29. [So] Source: J Nat Prod;80(9):2399-2405, 2017 Sep 22. [Is] ISSN: 1520-6025 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Bioassay-guided isolation of metabolites from cultures of the plant-derived fungus Emericella sp. TJ29 yielded three new terpene-polyketide hybrid meroterpenoids, emervaridones A-C (1-3), two new polyketides, varioxiranediols A and B (5 and 6), and three known analogues (4, 7, and 8). The structures and absolute configurations of these new compounds were elucidated by spectroscopic analyses, single-crystal X-ray diffraction, Mo (OAc) -induced electronic circular dichroism (ECD) data, and ECD calculations. To date, only one compound (4) bearing the emervaridone-type carbocyclic skeleton has been reported. The structures of emervaridones A-C (1-3) are new members of this type of natural product, and 1 features the first example of an α-directional H-7' in this structural category. Compounds 1 and 5 were active against five drug-resistant microbial pathogens [methicillin-resistant Staphylococcus aureus (MRSA), Enterococcus faecalis, extended-spectrum ß-lactamase-producing Escherichia coli (ESBL-producing E. coli), Pseudomonas aeruginosa, and Klebsiella pneumoniae] with minimum inhibitory concentration (MIC) values in the micrograms per milliliter range. Notably, the inhibitory effect of emervaridone A (1) against ESBL-producing E. coli was comparable to that of the clinically used antibiotic amikacin, with an MIC value of 2 µg/mL. Compounds 1 and 5, both with low toxicities to mammalian cells, were bacteriostatic and bactericidal, respectively. Importantly, these two compounds may provide novel chemical scaffolds for the discovery of antibacterial agents for drug-resistant microbial pathogens. [Mh] Termos MeSH primário: Antibacterianos/isolamento & purificação Antibacterianos/farmacologia Enterococcus faecalis/efeitos dos fármacos Escherichia coli/efeitos dos fármacos Klebsiella pneumoniae/efeitos dos fármacos Staphylococcus aureus Resistente à Meticilina/efeitos dos fármacos Policetídeos/farmacologia Pseudomonas aeruginosa/efeitos dos fármacos Terpenos/isolamento & purificação Terpenos/farmacologia beta-Lactamases/química [Mh] Termos MeSH secundário: Antibacterianos/química Bioensaio Emericella Testes de Sensibilidade Microbiana Estrutura Molecular Policetídeos/química Terpenos/química beta-Lactamases/metabolismo [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Anti-Bacterial Agents); 0 (Polyketides); 0 (Terpenes); 0 (emervaridone A); 0 (emervaridone B); 0 (emervaridone C); EC 3.5.2.6 (beta-Lactamases) [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171031 [Lr] Data última revisão: 171031 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170914 [St] Status: MEDLINE [do] DOI: 10.1021/acs.jnatprod.7b00077

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[PMID]: 28880897 [Au] Autor: Tian H; Wang H; Hui X; Wang Z; Drijber RA; Liu J [Ad] Endereço: Key Laboratory of Plant Nutrition and Agro-environment in Northwest China, Ministry of Agriculture/College of Natural Resources and Environment, Northwest A&F University, Yangling, Shaanxi, China. [Ti] Título: Changes in soil microbial communities after 10 years of winter wheat cultivation versus fallow in an organic-poor soil in the Loess Plateau of China. [So] Source: PLoS One;12(9):e0184223, 2017. [Is] ISSN: 1932-6203 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Agricultural management methods, such as cultivation or fallowing, have led to significant changes in soil fertility and hence, crop yield. Such changes may have stemmed from changes in soil microbial communities and associated biogeochemical processes. This phenomenon is particularly true in organic-poor soil in the Loess Plateau of China. In this study, we examined three existing soil management regimes as part of a 10-year field experiment and evaluated their effects on fungal and bacterial community structures by performing high-throughput 454 pyrosequencing. These management regimes were (i) fertilized winter wheat (Triticum aestivum L.) (FW), (ii) continuous natural fallow with weeds but without crop grown (NF), and (iii) continuous bare fallow without weeds or crop grown (BF). After 10 years, soil organic carbon (SOC), microbial biomass carbon (MBC), and available potassium (K) concentrations were highest in NF. Soil N behaved differently, with BF obtaining the highest nitrate nitrogen (N). Meanwhile, slight differences in total N (TN) were observed among FW, NF, and BF. Available phosphorus (P) was highest and available K was lowest in FW. Microbial communities were dominated by Ascomycota (59.1% of fungal sequences), and Acidobacteria, Actinobacteria, Bacteroidetes, Firmicutes, and Proteobacteria (75.7% of bacterial sequences) in FW, NF and BF at the phylum level. Soil management regimes did not affect the fungal and bacterial richness and diversity but significantly modified their community compositions. Compared with FW, the abundances of Ascomycota (fungi phylum) and Alternaria, Gibberella, and Emericella (fungi genus) were increased by NF, whereas the values of Chaetomium, Humicola, and Cryptococcus (fungi genus) were decreased by BF. The abundances of Verrucomicrobia (bacteria phylum), and Steroidobacter (bacteria genus) were increased by NF, and Bacteroides (bacteria genus) was increased by BF. Canonical correspondence analysis showed that SOC, available P, and TN might be the key factors in community formation. Therefore, the decadal absence of plants (BF) affected soil fertility by increased available K and nitrate N, whileas natural fallow (NF) affected soil fertility by increased SOC, available K, and MBC, and they all changed fungal and bacterial community compositions. [Mh] Termos MeSH primário: Microbiologia do Solo Solo/classificação Triticum [Mh] Termos MeSH secundário: Alternaria/isolamento & purificação Ascomicetos/isolamento & purificação Biomassa Carbono Chaetomium/isolamento & purificação China Cryptococcus/isolamento & purificação Emericella/isolamento & purificação Gibberella/isolamento & purificação Nitrogênio/análise Potássio/análise [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Soil); 7440-44-0 (Carbon); N762921K75 (Nitrogen); RWP5GA015D (Potassium) [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171116 [Lr] Data última revisão: 171116 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170908 [St] Status: MEDLINE [do] DOI: 10.1371/journal.pone.0184223

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[PMID]: 28245269 [Au] Autor: Yashavantha Rao HC; Rakshith D; Harini BP; Gurudatt DM; Satish S [Ad] Endereço: Microbial Drugs Laboratory, Department of Studies in Microbiology, University of Mysore, Manasagangotri, Mysore, Karnataka, India. [Ti] Título: Chemogenomics driven discovery of endogenous polyketide anti-infective compounds from endosymbiotic Emericella variecolor CLB38 and their RNA secondary structure analysis. [So] Source: PLoS One;12(2):e0172848, 2017. [Is] ISSN: 1932-6203 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: In the postgenomic era, a new strategy for chemical dereplication of polyketide anti-infective drugs requires novel genomics and chromatographic strategies. An endosymbiotic fungal strain CLB38 was isolated from the root tissue of Combretum latifolium Blume (Combretaceae) which was collected from the Western Ghats of India. The isolate CLB38 was then identified as Emericella variecolor by its characteristic stellate ascospores culture morphology and molecular analysis of ITS nuclear rDNA and intervening 5.8S rRNA gene sequence. ITS2 RNA secondary structure modeling clearly distinguished fungal endosymbiont E. variecolor CLB38 with other lifestyles in the same monophyletic clade. Ethyl acetate fraction of CLB38 explored a broad spectrum of antimicrobial activity against multidrug resistant pathogens. Biosynthetic PKS type-I gene and chromatographic approach afford two polyketide antimicrobial compounds which identified as evariquinone and isoindolones derivative emerimidine A. MIC of purified compounds against test microorganisms ranged between 3.12 µg/ml and 12.5 µg/ml. This research highlights the utility of E. variecolor CLB38 as an anticipate source for anti-infective polyketide metabolites evariquinone and emerimidine A to combat multidrug resistant microorganisms. Here we demonstrates a chemogenomics strategy via the feasibility of PKS type-I gene and chromatographic approach as a proficient method for the rapid prediction and discovery of new polyketides compounds from fungal endosymbionts. [Mh] Termos MeSH primário: Combretaceae/microbiologia Emericella/química Emericella/fisiologia [Mh] Termos MeSH secundário: Anti-Infecciosos/química Anti-Infecciosos/farmacologia DNA Ribossômico/genética Emericella/genética Isoindóis/química Isoindóis/farmacologia Testes de Sensibilidade Microbiana Policetídeos/química Policetídeos/farmacologia RNA Fúngico/genética Simbiose [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Anti-Infective Agents); 0 (DNA, Ribosomal); 0 (Isoindoles); 0 (Polyketides); 0 (RNA, Fungal); 0 (emerimidine) [Em] Mês de entrada: 1708 [Cu] Atualização por classe: 170828 [Lr] Data última revisão: 170828 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170301 [St] Status: MEDLINE [do] DOI: 10.1371/journal.pone.0172848

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[PMID]: 27091580 [Au] Autor: Mutlu FM; Yildiran ST; Saracli MA; Gümral R; Durukan H; Sobaci G; Mutlu AG [Ad] Endereço: Departments of Ophthalmology, Ankara, Turkey. [Ti] Título: The first case of fungal endophthalmitis caused by Emericella nidulans after cataract surgery. [So] Source: J Mycol Med;26(3):271-6, 2016 Sep. [Is] ISSN: 1773-0449 [Cp] País de publicação: France [La] Idioma: eng [Ab] Resumo: Emericella nidulans is a species that has only rarely been implicated in human disease after cataract surgery. Here, we report the first postoperative case in the literature, as far as we know. The patient was a 50-year-old patient presented with mild anterior uveitis one week after cataract surgery, and hypopion developed over the next two days. First microbiological evaluation and the results of direct microscopy and cultures of the anterior chamber and vitreous samples were found to be negative. Despite vigorous topical and intravitreal (vancomycin and amikacin) therapy, the endophthalmitis did not improve. Anterior chamber paracentesis, vitreous tap and finally complete vitrectomy with removal of the capsular bag including the intraocular lens (IOL) were performed. The anterior chamber, vitreous fluid samples and IOL were submitted to the microbiology laboratory: the culture yielded E. nidulans growth. Ocular inflammation resolved and vision improved on intravenous, subconjunctival and long-term oral voriconazole treatment. E. nidulans can be an important cause of ocular fungal infections including endophthalmitis, and voriconazole seems to be effective for the treatment of E. nidulans endophthalmitis. [Mh] Termos MeSH primário: Extração de Catarata/efeitos adversos Emericella/isolamento & purificação Endoftalmite/microbiologia Infecções Oculares Fúngicas/diagnóstico Complicações Pós-Operatórias/microbiologia [Mh] Termos MeSH secundário: Antifúngicos/uso terapêutico Aspergilose/diagnóstico Aspergilose/tratamento farmacológico Aspergilose/microbiologia Aspergillus nidulans/isolamento & purificação Emericella/crescimento & desenvolvimento Endoftalmite/diagnóstico Endoftalmite/tratamento farmacológico Infecções Oculares Fúngicas/tratamento farmacológico Infecções Oculares Fúngicas/microbiologia Feminino Seres Humanos Meia-Idade Complicações Pós-Operatórias/tratamento farmacológico Voriconazol/uso terapêutico [Pt] Tipo de publicação: CASE REPORTS; JOURNAL ARTICLE [Nm] Nome de substância: 0 (Antifungal Agents); JFU09I87TR (Voriconazole) [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 170907 [Lr] Data última revisão: 170907 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 160420 [St] Status: MEDLINE

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[PMID]: 26731665 [Au] Autor: Matsuda Y; Quan Z; Mitsuhashi T; Li C; Abe I [Ad] Endereço: Graduate School of Pharmaceutical Sciences, The University of Tokyo , 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. [Ti] Título: Cytochrome P450 for Citreohybridonol Synthesis: Oxidative Derivatization of the Andrastin Scaffold. [So] Source: Org Lett;18(2):296-9, 2016 Jan 15. [Is] ISSN: 1523-7052 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: A biosynthetic gene cluster similar to that for andrastin A (1) was discovered in Emericella variecolor NBRC 32302. Ctr-P450, a cytochrome P450 uniquely present in the cluster, was coexpressed with the andrastin A biosynthetic genes, leading to the production of the antifeedant agent citreohybridonol (4), along with four new andrastin derivatives. The results revealed the unusual multifunctionality of Ctr-P450 and indicated that this approach can be applied for further natural product diversification. [Mh] Termos MeSH primário: Androstadienos/síntese química Sistema Enzimático do Citocromo P-450/metabolismo [Mh] Termos MeSH secundário: Androstadienos/química Emericella/química Farnesiltranstransferase/antagonistas & inibidores Comportamento Alimentar/efeitos dos fármacos Estrutura Molecular Família Multigênica Oxirredução [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (Androstadienes); 0 (andrastin A); 0 (andrastin C); 0 (citreohybridonol); 9035-51-2 (Cytochrome P-450 Enzyme System); EC 2.5.1.29 (Farnesyltranstransferase) [Em] Mês de entrada: 1606 [Cu] Atualização por classe: 160115 [Lr] Data última revisão: 160115 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 160106 [St] Status: MEDLINE [do] DOI: 10.1021/acs.orglett.5b03465

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[PMID]: 26718087 [Au] Autor: Liangsakul J; Srisurichan S; Pornpakakul S [Ad] Endereço: Research Centre for Bioorganic Chemistry, Department of Chemistry, Faculty of Science, Chulalongkorn University, Phayathai Road, Bangkok 10330, Thailand. [Ti] Título: Anthraquinone-steroids, evanthrasterol A and B, and a meroterpenoid, emericellic acid, from endophytic fungus, Emericella variecolor. [So] Source: Steroids;106:78-85, 2016 Feb. [Is] ISSN: 1878-5867 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Two new anthraquinone-steroids, evanthrasterol A and B (1 and 2), and a new meroterpenoid, emericellic acid (3), together with six known compounds (4-9) were isolated from an endophytic fungus, Emericella variecolor. Their structures were determined by spectroscopic analysis (1D and 2D NMR, HRESIMS and FTIR). Herein emericellic acid (3) is a new skeleton of meroterpenoid with carboxylic functional group at C-9' and this is the first report on isolation of anthraquinone-steroids from E. variecolor. [Mh] Termos MeSH primário: Antraquinonas/química Emericella/química Ergosterol/análogos & derivados Sesterterpenos/química [Mh] Termos MeSH secundário: Antraquinonas/isolamento & purificação Emericella/metabolismo Ergosterol/química Ergosterol/isolamento & purificação Modelos Moleculares Conformação Molecular Sesterterpenos/isolamento & purificação [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (Anthraquinones); 0 (Sesterterpenes); Z30RAY509F (Ergosterol) [Em] Mês de entrada: 1612 [Cu] Atualização por classe: 161230 [Lr] Data última revisão: 161230 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 160101 [St] Status: MEDLINE

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[PMID]: 26563166 [Au] Autor: Ishiwada N; Takeshita K; Yaguchi T; Nagasawa K; Takeuchi N; Hishiki H; Watanabe A; Kamei K; Shimojo N [Ad] Endereço: Department of Infectious Diseases, Medical Mycology Research Center, Chiba University, Chiba, Japan. ishiwada@faculty.chiba-u.jp. [Ti] Título: The First Case of Invasive Mixed-Mold Infections Due to Emericella nidulans var. echinulata and Rasamsonia piperina in a Patient with Chronic Granulomatous Disease. [So] Source: Mycopathologia;181(3-4):305-9, 2016 Apr. [Is] ISSN: 1573-0832 [Cp] País de publicação: Netherlands [La] Idioma: eng [Ab] Resumo: A 16-year-old boy with chronic granulomatous disease presented with pneumonia and rib osteomyelitis. Emericella nidulans var. echinulata was isolated from his sputum. After starting voriconazole, Rasamsonia piperina was isolated from the rib swelling. A combination therapy of voriconazole and micafungin effectively eradicated this invasive mixed-mold infection. In immunocompromised patients, a precise pathogenic diagnosis is clinically useful for administration of an appropriate treatment regimen. [Mh] Termos MeSH primário: Antifúngicos/uso terapêutico Ascomicetos/efeitos dos fármacos Equinocandinas/uso terapêutico Emericella/efeitos dos fármacos Doença Granulomatosa Crônica/microbiologia Lipopeptídeos/uso terapêutico Micoses/tratamento farmacológico Micoses/microbiologia Voriconazol/uso terapêutico [Mh] Termos MeSH secundário: Adolescente Ascomicetos/isolamento & purificação Coinfecção/tratamento farmacológico Emericella/isolamento & purificação Seres Humanos Hospedeiro Imunocomprometido Masculino Escarro/microbiologia [Pt] Tipo de publicação: CASE REPORTS; JOURNAL ARTICLE [Nm] Nome de substância: 0 (Antifungal Agents); 0 (Echinocandins); 0 (Lipopeptides); JFU09I87TR (Voriconazole); R10H71BSWG (micafungin) [Em] Mês de entrada: 1612 [Cu] Atualização por classe: 171030 [Lr] Data última revisão: 171030 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 151114 [St] Status: MEDLINE [do] DOI: 10.1007/s11046-015-9963-5

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[PMID]: 26546087 [Au] Autor: Qin B; Matsuda Y; Mori T; Okada M; Quan Z; Mitsuhashi T; Wakimoto T; Abe I [Ad] Endereço: Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan. [Ti] Título: An Unusual Chimeric Diterpene Synthase from Emericella variecolor and Its Functional Conversion into a Sesterterpene Synthase by Domain Swapping. [So] Source: Angew Chem Int Ed Engl;55(5):1658-61, 2016 Jan 26. [Is] ISSN: 1521-3773 [Cp] País de publicação: Germany [La] Idioma: eng [Ab] Resumo: Di- and sesterterpene synthases produce C20 and C25 isoprenoid scaffolds from geranylgeranyl pyrophosphate (GGPP) and geranylfarnesyl pyrophosphate (GFPP), respectively. By genome mining of the fungus Emericella variecolor, we identified a multitasking chimeric terpene synthase, EvVS, which has terpene cyclase (TC) and prenyltransferase (PT) domains. Heterologous gene expression in Aspergillus oryzae led to the isolation of variediene (1), a novel tricyclic diterpene hydrocarbon. Intriguingly, in vitro reaction with the enzyme afforded the new macrocyclic sesterterpene 2 as a minor product from dimethylallyl pyrophosphate (DMAPP) and isopentenyl pyrophosphate (IPP). The TC domain thus produces the diterpene 1 and the sesterterpene 2 from GGPP and GFPP, respectively. Notably, a domain swap of the PT domain of EvVS with that of another chimeric sesterterpene synthase, EvSS, successfully resulted in the production of 2 in vivo as well. Cyclization mechanisms for the production of these two compounds are proposed. [Mh] Termos MeSH primário: Alquil e Aril Transferases/química Diterpenos/química Emericella/enzimologia Sesterterpenos/química [Mh] Termos MeSH secundário: Alquil e Aril Transferases/genética Aspergillus oryzae/genética Cromatografia Gasosa-Espectrometria de Massas [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (Diterpenes); 0 (Sesterterpenes); EC 2.5.- (Alkyl and Aryl Transferases); EC 2.5.1.- (terpene synthase) [Em] Mês de entrada: 1610 [Cu] Atualização por classe: 161230 [Lr] Data última revisão: 161230 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 151108 [St] Status: MEDLINE [do] DOI: 10.1002/anie.201509263

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[PMID]: 26306816 [Au] Autor: Saito T; Itabashi T; Wakana D; Takeda H; Yaguchi T; Kawai K; Hosoe T [Ad] Endereço: Department of Organic Chemistry, Hoshi University, Tokyo, Japan. [Ti] Título: Isolation and structure elucidation of new phthalide and phthalane derivatives, isolated as antimicrobial agents from Emericella sp. IFM57991. [So] Source: J Antibiot (Tokyo);69(2):89-96, 2016 Feb. [Is] ISSN: 0021-8820 [Cp] País de publicação: Japan [La] Idioma: eng [Ab] Resumo: Three new phthalide derivatives, emefuranones A1, A2 and B (1-3); six new phthalane derivatives, emefuran A, B1, B2, C1, C2 and D (4-9); three new farnesylated phthalide derivatives, farnesylemefuranones A-C (10-12); xylarinol C (13); and emericelloxide (14), along with four known compounds (dustanin, sorbicillin, aspergillodiol and xylarinol A), were isolated from the culture extracts of Emericella sp. IFM57991. Structures of 1-14 were elucidated on the basis of spectroscopic analysis and chemical evidence. Compounds 4-7 and 13 showed moderate antibacterial activities against Bacillus subtilis. [Mh] Termos MeSH primário: Anti-Infecciosos/farmacologia Bacillus subtilis/efeitos dos fármacos Benzofuranos/farmacologia Meios de Cultura/química Emericella/metabolismo Ftalimidas/farmacologia [Mh] Termos MeSH secundário: Anti-Infecciosos/química Anti-Infecciosos/isolamento & purificação Benzofuranos/química Benzofuranos/isolamento & purificação Testes de Sensibilidade a Antimicrobianos por Disco-Difusão Emericella/crescimento & desenvolvimento Seres Humanos Espectroscopia de Ressonância Magnética Modelos Moleculares Estrutura Molecular Ftalimidas/química Ftalimidas/isolamento & purificação [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Anti-Infective Agents); 0 (Benzofurans); 0 (Culture Media); 0 (Phthalimides); 8VV922U86J (phthalide); X5NFK36917 (folpet) [Em] Mês de entrada: 1607 [Cu] Atualização por classe: 170220 [Lr] Data última revisão: 170220 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 150827 [St] Status: MEDLINE [do] DOI: 10.1038/ja.2015.85

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[PMID]: 26700546 [Au] Autor: Wu Q; Long HL; Liu D; Proksch P; Lin WH [Ad] Endereço: a State Key Laboratory of Natural and Biomimetic Drugs , Peking University , Beijing 100191 , China. [Ti] Título: Varioxiranols I-L, new lactones from a sponge-associated Emericella variecolor fungus. [So] Source: J Asian Nat Prod Res;17(12):1137-45, 2015. [Is] ISSN: 1477-2213 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Chemical examination of the sponge-associated fungus Emericella variecolor resulted in the isolation of four new lactones namely varioxiranols I-L(1-4)with different scaffolds, together with asteltoxin (5) and asteltoxin B (6). The structure elucidation of new compounds was accomplished by spectroscopic analysis, while the absolute configurations were determined by computed circular dichroism (ECD) and induced CD effects. Antitumor activities of these compounds were evaluated against different tumor cell lines, while the result indicated that the new compounds showed moderate cytotoxic activity against a panel of tumor cell lines. [Mh] Termos MeSH primário: Antineoplásicos/isolamento & purificação Emericella/química Policetídeos/isolamento & purificação Poríferos/microbiologia [Mh] Termos MeSH secundário: Animais Antineoplásicos/química Antineoplásicos/farmacologia Ensaios de Seleção de Medicamentos Antitumorais Seres Humanos Lactonas Estrutura Molecular Policetídeos/química Policetídeos/farmacologia Pironas [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (Antineoplastic Agents); 0 (Lactones); 0 (Polyketides); 0 (Pyrones); 0 (varioxiranol I); 72061-91-7 (asteltoxin) [Em] Mês de entrada: 1605 [Cu] Atualização por classe: 160114 [Lr] Data última revisão: 160114 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 151225 [St] Status: MEDLINE [do] DOI: 10.1080/10286020.2015.1119127

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1			PalavrasDescritor de assuntoDescritor de assunto primárioLimitesAutorPalavras do títuloPalavras do resumoIdiomaPaís de publicaçãoNome de substânciaNome de pessoa como assuntoRevistaAssunto de RevistaISSNTipo de publicaçãoIdentificador únicoMês de entradaAno de publicaçãoTexto completoAtualização por classeCategoria DeCSCategoria DeCS explodidaCategoria CID-10SubSetsPais de AfiliaçãoAfiliaçãoAfiliação 2
2	and or and not		PalavrasDescritor de assuntoDescritor de assunto primárioLimitesAutorPalavras do títuloPalavras do resumoIdiomaPaís de publicaçãoNome de substânciaNome de pessoa como assuntoRevistaAssunto de RevistaISSNTipo de publicaçãoIdentificador únicoMês de entradaAno de publicaçãoTexto completoAtualização por classeCategoria DeCSCategoria DeCS explodidaCategoria CID-10SubSetsPais de AfiliaçãoAfiliaçãoAfiliação 2
3	and or and not		PalavrasDescritor de assuntoDescritor de assunto primárioLimitesAutorPalavras do títuloPalavras do resumoIdiomaPaís de publicaçãoNome de substânciaNome de pessoa como assuntoRevistaAssunto de RevistaISSNTipo de publicaçãoIdentificador únicoMês de entradaAno de publicaçãoTexto completoAtualização por classeCategoria DeCSCategoria DeCS explodidaCategoria CID-10SubSetsPais de AfiliaçãoAfiliaçãoAfiliação 2

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