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Pesquisa : B01.300.107.320.218 [Categoria DeCS]
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[PMID]:28586721
[Au] Autor:May Zin WW; Buttachon S; Dethoup T; Pereira JA; Gales L; Inácio Â; Costa PM; Lee M; Sekeroglu N; Silva AMS; Pinto MMM; Kijjoa A
[Ad] Endereço:ICBAS-Instituto de Ciências Biomédicas Abel Salazar, Rua de Jorge Viterbo Ferreira, 228, 4050-313, Porto, Portugal; Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), Terminal de Cruzeiros do Porto de Lexões, Av. General Norton de Matos s/n, 4450-208, Matosinhos, Portugal. Elect
[Ti] Título:Antibacterial and antibiofilm activities of the metabolites isolated from the culture of the mangrove-derived endophytic fungus Eurotium chevalieri KUFA 0006.
[So] Source:Phytochemistry;141:86-97, 2017 Sep.
[Is] ISSN:1873-3700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Five previously undescribed metabolites, including acetylquestinol, two prenylated indole 3-carbaldehyde derivatives, an anthranilic acid derivative and an isochromone derivative, were isolated, in addition to eleven known compounds: palmitic acid, ergosterol 5,8-endoperoxide, emodin, physcion, questin, questinol, (11S, 14R)-cyclo(tryptophylvalyl), preechinulin, neoechinulin E, echinulin and eurocristatine, from the culture of the endophytic fungus Eurotium chevalieri KUFA 0006. The structures of the previously undescribed compounds were established based on an extensive 1D and 2D NMR spectral analysis as well as HRMS and IR data. In case of 2-(2, 2-dimethylcyclopropyl)-1H-indole-3-carbaldehyde and 6, 8-dihydroxy-3-(2S-hydroxypropyl)-7-methylisochromone, the absolute configurations of their stereogenic carbons were established based on comparison of their experimental and calculated ECD spectra. All the compounds, except for palmitic acid and ergosterol 5, 8-endoperoxide, were evaluated for their antibacterial and antibiofilm activities against two Gram-positive and two Gram-negative bacteria, as well as multidrug-resistant isolates from the environment. Emodin not only exhibited moderate antibacterial activity against the Gram-positive bacteria but also showed strong synergistic association with oxacillin against MRSA Staphylococcus aureus.
[Mh] Termos MeSH primário: Antibacterianos/química
Biofilmes/efeitos dos fármacos
Eurotium/química
[Mh] Termos MeSH secundário: Antraquinonas/química
Antraquinonas/isolamento & purificação
Antibacterianos/isolamento & purificação
Cromonas/química
Cromonas/isolamento & purificação
Emodina/química
Emodina/isolamento & purificação
Indóis/química
Indóis/isolamento & purificação
Staphylococcus aureus Resistente à Meticilina/efeitos dos fármacos
Testes de Sensibilidade Microbiana
Estrutura Molecular
Rhizophoraceae/microbiologia
ortoaminobenzoatos/química
ortoaminobenzoatos/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anthraquinones); 0 (Anti-Bacterial Agents); 0 (Chromones); 0 (Indoles); 0 (ortho-Aminobenzoates); 0YS975XI6W (anthranilic acid); 7FN04C32UO (indole-3-carbaldehyde); KA46RNI6HN (Emodin)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170721
[Lr] Data última revisão:
170721
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170607
[St] Status:MEDLINE


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[PMID]:28125012
[Au] Autor:Du FY; Li X; Li XM; Zhu LW; Wang BG
[Ad] Endereço:Laboratory of Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Nanhai Road 7, Qingdao 266071, China. fooddfy@126.com.
[Ti] Título:Indolediketopiperazine Alkaloids from Eurotium cristatum EN-220, an Endophytic Fungus Isolated from the Marine Alga Sargassum thunbergii.
[So] Source:Mar Drugs;15(2), 2017 Jan 25.
[Is] ISSN:1660-3397
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Four new indolediketopiperazine derivatives ( - ), along with nine known congeners ( - ), were isolated and identified from the culture extract of EN-220, an endophytic fungus obtained from the marine alga . The structures of thesecompounds were elucidated on the basis of extensive spectroscopic analysis and the absolute configurations of compounds - were established by NOESY experiments and by chiral HPLC analyses of their acid hydrolysates. The absolute configuration of C-8 (a quaternary carbon substituted with a hydroxyl group) in of preechinulin class was firstly determined by electronic circular dichroism (ECD) calculations. All these compounds were evaluatedfor brine shrimp ( ) lethality and nematicidal activity as well as antioxidativeand antimicrobial potency.
[Mh] Termos MeSH primário: Alcaloides/farmacologia
Eurotium/química
Fungos/química
Sargassum/química
[Mh] Termos MeSH secundário: Animais
Antibacterianos/química
Antibacterianos/farmacologia
Antioxidantes/química
Antioxidantes/farmacologia
Organismos Aquáticos/química
Organismos Aquáticos/microbiologia
Artemia/efeitos dos fármacos
Dicroísmo Circular/métodos
Testes de Sensibilidade Microbiana/métodos
Sargassum/microbiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkaloids); 0 (Anti-Bacterial Agents); 0 (Antioxidants)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170616
[Lr] Data última revisão:
170616
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170127
[St] Status:MEDLINE


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[PMID]:28121266
[Au] Autor:Cecchi G; Roccotiello E; Di Piazza S; Riggi A; Mariotti MG; Zotti M
[Ad] Endereço:a Laboratory of Mycology, DISTAV , University of Genoa , Genoa , Italy.
[Ti] Título:Assessment of Ni accumulation capability by fungi for a possible approach to remove metals from soils and waters.
[So] Source:J Environ Sci Health B;52(3):166-170, 2017 Mar 04.
[Is] ISSN:1532-4109
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Abandoned industrial sites and mines may constitute possible hazards for surrounding environment due to the presence of toxic compounds that may contaminate soils and waters. The possibility to remove metal contaminants, specifically nickel (Ni), by means of fungi was presented exploiting a set of fungal strains isolated from a Ligurian dismissed mine. The achieved results demonstrate the high Ni(II) tolerance, up to 500 mg Ni l , and removal capability of a Trichoderma harzianum strain. This latter hyperaccumulates up to 11,000 mg Ni kg , suggesting its possible use in a bioremediation protocol able to provide a sustainable reclamation of broad contaminated areas.
[Mh] Termos MeSH primário: Biodegradação Ambiental
Fungos/metabolismo
Metais Pesados/metabolismo
Poluentes do Solo/metabolismo
Solo/química
Água/química
[Mh] Termos MeSH secundário: Aspergillus/metabolismo
Eurotium/metabolismo
Itália
Mineração
Trichoderma/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Metals, Heavy); 0 (Soil); 0 (Soil Pollutants); 059QF0KO0R (Water)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170126
[St] Status:MEDLINE
[do] DOI:10.1080/03601234.2017.1261539


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[PMID]:27627699
[Au] Autor:Chen M; Zhao Q; Hao JD; Wang CY
[Ad] Endereço:a Marine Science & Technology Institute, College of Environmental Science & Engineering , Yangzhou University , Yangzhou , People's Republic of China.
[Ti] Título:Two benzaldehyde derivatives and their artefacts from a gorgonian-derived Eurotium sp. fungus.
[So] Source:Nat Prod Res;31(3):268-274, 2017 Feb.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Two new benzaldehyde derivatives, named 3'-OH-tetrahydroauroglaucin (1) and(3'S*,4'R*)-6-(3',5-epoxy-4'-hydroxy-1'-heptenyl)-2-hydroxy-3-(3''-methyl-2''-butenyl)benzaldehyde (2), were isolated from a gorgonian-derived Eurotium sp. fungus. Their structures were determined by extensive spectroscopic analysis including NMR and MS spectra. Dissolved 1 in CDCl for several days could be detected its 2H-chromene skeleton derivatives (1a/1b), a pair of enantiomers with opposite configurations at C-3'. Compound 2 was also found to chemically convert to a pair of epimers non-enzymatically. The plausible mechanism to form the 2H-chromene artefacts with racemisation at C-3' undergoing nucleophilic substitution (S 1) was proposed.
[Mh] Termos MeSH primário: Benzaldeídos/química
Eurotium/química
[Mh] Termos MeSH secundário: Animais
Antozoários/microbiologia
Artefatos
Benzaldeídos/isolamento & purificação
Benzopiranos/química
Espectroscopia de Ressonância Magnética
Estrutura Molecular
Estereoisomerismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (5,7-dimethoxy-2-methyl-2H-benzopyran); 0 (Benzaldehydes); 0 (Benzopyrans); TA269SD04T (benzaldehyde)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160915
[St] Status:MEDLINE


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[PMID]:27325576
[Au] Autor:Dagnas S; Gougouli M; Onno B; Koutsoumanis KP; Membré JM
[Ad] Endereço:L'Université Nantes Angers Le Mans, Oniris, Nantes F-44322 cedex 3, France.
[Ti] Título:Quantifying the effect of water activity and storage temperature on single spore lag times of three moulds isolated from spoiled bakery products.
[So] Source:Int J Food Microbiol;240:75-84, 2017 Jan 02.
[Is] ISSN:1879-3460
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The inhibitory effect of water activity (a ) and storage temperature on single spore lag times of Aspergillus niger, Eurotium repens (Aspergillus pseudoglaucus) and Penicillium corylophilum strains isolated from spoiled bakery products, was quantified. A full factorial design was set up for each strain. Data were collected at levels of a varying from 0.80 to 0.98 and temperature from 15 to 35°C. Experiments were performed on malt agar, at pH5.5. When growth was observed, ca 20 individual growth kinetics per condition were recorded up to 35days. Radius of the colony vs time was then fitted with the Buchanan primary model. For each experimental condition, a lag time variability was observed, it was characterized by its mean, standard deviation (sd) and 5 percentile, after a Normal distribution fit. As the environmental conditions became stressful (e.g. storage temperature and a lower), mean and sd of single spore lag time distribution increased, indicating longer lag times and higher variability. The relationship between mean and sd followed a monotonous but not linear pattern, identical whatever the species. Next, secondary models were deployed to estimate the cardinal values (minimal, optimal and maximal temperatures, minimal water activity where no growth is observed anymore) for the three species. That enabled to confirm the observation made based on raw data analysis: concerning the temperature effect, A. niger behaviour was significantly different from E. repens and P. corylophilum: T of 37.4°C (standard deviation 1.4°C) instead of 27.1°C (1.4°C) and 25.2°C (1.2°C), respectively. Concerning the a effect, from the three mould species, E. repens was the species able to grow at the lowest a (aw estimated to 0.74 (0.02)). Finally, results obtained with single spores were compared to findings from a previous study carried out at the population level (Dagnas et al., 2014). For short lag times (≤5days), there was no difference between lag time of the population (ca 2000 spores inoculated in one spot) and mean (nor 5 percentile) of single spore lag time distribution. In contrast, when lag time was longer, i.e. under more stressful conditions, there was a discrepancy between individual and population lag times (population lag times shorter than 5 percentiles of single spore lag time distribution), confirming a stochastic process. Finally, the temperature cardinal values estimated with single spores were found to be similar to those obtained at the population level, whatever the species. All these findings will be used to describe better mould spore lag time variability and then to predict more accurately bakery product shelf-life.
[Mh] Termos MeSH primário: Aspergillus niger/crescimento & desenvolvimento
Eurotium/crescimento & desenvolvimento
Microbiologia de Alimentos
Armazenamento de Alimentos
Temperatura Alta
Penicillium/crescimento & desenvolvimento
Esporos Fúngicos/crescimento & desenvolvimento
Água/química
[Mh] Termos MeSH secundário: Aspergillus niger/isolamento & purificação
Eurotium/isolamento & purificação
Cinética
Penicillium/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
059QF0KO0R (Water)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160622
[St] Status:MEDLINE


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[PMID]:27641468
[Au] Autor:Kamauchi H; Kinoshita K; Sugita T; Koyama K
[Ad] Endereço:Department of Pharmacognosy and Phytochemistry, Meiji Pharmaceutical University, Noshio 2-522-1, Kiyose-shi, Tokyo 204-8588, Japan.
[Ti] Título:Conditional changes enhanced production of bioactive metabolites of marine derived fungus Eurotium rubrum.
[So] Source:Bioorg Med Chem Lett;26(20):4911-4914, 2016 10 15.
[Is] ISSN:1464-3405
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Metabolites of marine derived fungus Eurotium rubrum MPUC136 differed between cultivation on wheat medium and Czapek-Dox agar medium. Melanin synthesis inhibitory activity of crude extract of culture on wheat medium showed stronger activity than that of crude extract of culture on Czapek-Dox agar medium. A new diketopiperazine compound isoechinulin D (1) and eight reported diketopiperazines (2-9) were isolated from the crude extract of wheat medium. The structure of 1 was established using NMR, MS and IR methods. 2-5 inhibited melanogenesis using B16 melanoma cells (IC =68, 2.4, 83, 9.1µM each). Structure-Activity-Relationships of diketopiperazines (1-10) indicated the importance of the prenyl groups at C-2, C-5 and C-7, the vinyl group at C-12 to C-25 and the sp carbons at C-8 and C-9. Isolated compounds (1-9) were not or slightly observed from the extracts of Czapek-Dox agar medium by HPLC analysis, suggesting that different cultivation processes could affect metabolism and enhance bioactivities.
[Mh] Termos MeSH primário: Eurotium/química
Biologia Marinha
[Mh] Termos MeSH secundário: Animais
Linhagem Celular Tumoral
Cromatografia Líquida de Alta Pressão
Camundongos
Análise Espectral/métodos
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171122
[Lr] Data última revisão:
171122
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160920
[St] Status:MEDLINE


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[PMID]:27350657
[Au] Autor:Le Lay C; Coton E; Le Blay G; Chobert JM; Haertlé T; Choiset Y; Van Long NN; Meslet-Cladière L; Mounier J
[Ad] Endereço:Université de Brest, EA 3882, Laboratoire Universitaire de Biodiversité et Ecologie Microbienne, ESIAB, Technopôle Brest-Iroise, 29280 Plouzané, France.
[Ti] Título:Identification and quantification of antifungal compounds produced by lactic acid bacteria and propionibacteria.
[So] Source:Int J Food Microbiol;239:79-85, 2016 Dec 19.
[Is] ISSN:1879-3460
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Fungal growth in bakery products represents the most frequent cause of spoilage and leads to economic losses for industrials and consumers. Bacteria, such as lactic acid bacteria and propionibacteria, are commonly known to play an active role in preservation of fermented food, producing a large range of antifungal metabolites. In a previous study (Le Lay et al., 2016), an extensive screening performed both in vitro and in situ allowed for the selection of bacteria exhibiting an antifungal activity. In the present study, active supernatants against Penicillium corylophilum and Aspergillus niger were analyzed to identify and quantify the antifungal compounds associated with the observed activity. Supernatant treatments (pH neutralization, heating and addition of proteinase K) suggested that organic acids played the most important role in the antifungal activity of each tested supernatant. Different methods (HPLC, mass spectrometry, colorimetric and enzymatic assays) were then applied to analyze the supernatants and it was shown that the main antifungal compounds corresponded to lactic, acetic and propionic acids, ethanol and hydrogen peroxide, as well as other compounds present at low levels such as phenyllactic, hydroxyphenyllactic, azelaic and caproic acids. Based on these results, various combinations of the identified compounds were used to evaluate their effect on conidial germination and fungal growth of P. corylophilum and Eurotium repens. Some combinations presented the same activity than the bacterial culture supernatant thus confirming the involvement of the identified molecules in the antifungal activity. The obtained results suggested that acetic acid was mainly responsible for the antifungal activity against P. corylophilum and played an important role in E. repens inhibition.
[Mh] Termos MeSH primário: Antifúngicos/metabolismo
Aspergillus niger/crescimento & desenvolvimento
Lactobacillaceae/metabolismo
Penicillium/crescimento & desenvolvimento
Propionibacterium/metabolismo
Esporos Fúngicos/crescimento & desenvolvimento
[Mh] Termos MeSH secundário: Ácido Acético/metabolismo
Caproatos/metabolismo
Ácidos Dicarboxílicos/metabolismo
Etanol/metabolismo
Eurotium/crescimento & desenvolvimento
Peróxido de Hidrogênio/metabolismo
Concentração de Íons de Hidrogênio
Ácido Láctico/metabolismo
Testes de Sensibilidade Microbiana
Propionatos/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (Caproates); 0 (Dicarboxylic Acids); 0 (Propionates); 1F8SN134MX (hexanoic acid); 33X04XA5AT (Lactic Acid); 3K9958V90M (Ethanol); BBX060AN9V (Hydrogen Peroxide); F2VW3D43YT (azelaic acid); Q40Q9N063P (Acetic Acid)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160629
[St] Status:MEDLINE


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[PMID]:26556374
[Au] Autor:Greco M; Pardo A; Pose G
[Ad] Endereço:Laboratorio de Micología Molecular, Departamento de Ciencia y Tecnología, Universidad Nacional de Quilmes (UNQ), Roque Sáenz Peña 352, Bernal, Buenos Aires 1876, Argentina. mariana.greco@gmail.com.
[Ti] Título:Mycotoxigenic fungi and natural co-occurrence of mycotoxins in rainbow trout (Oncorhynchus mykiss) feeds.
[So] Source:Toxins (Basel);7(11):4595-609, 2015 Nov 05.
[Is] ISSN:2072-6651
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Samples of rainbow trout feed were analyzed with the aim to determine the mycobiota composition and the co-occurrence of mycotoxins. A total of 28 samples of finished rainbow trout feed from hatcheries in the provinces of Río Negro and Neuquén, Argentina, were studied. Fungal counts were obtained on three culture media in the ranges of <10 to 4.2 × 104 CFU/g on Dichloran Rose Bengal Chloramphenicol Agar (DRBC), <10 to 5.1 × 104 CFU/g on Dichloran Chloramphenicol Peptone Agar (DCPA) and <10 to 3.6 × 104 CFU/g on Dichloran 18% Glycerol Agar (DG18). The most frequent mycotoxigenic fungi were Eurotium (frequency (Fr) 25.0%), followed by Penicillium (Fr 21.4%) and Aspergillus (Fr 3.6%). The most prevalent mycotoxigenic species were E. repens (Fr 21.4%) and E. rubrum (Fr 14.3%). All samples were contaminated with mycotoxins: 64% samples were contaminated with T-2 toxin (median 70.08 ppb), 50% samples with zearalenone (median 87.97 ppb) and aflatoxins (median 2.82 ppb), 25% with ochratoxin A (median 5.26 ppb) and 3.57% samples with deoxynivalenol (median 230 ppb). Eight samples had a fumonisins contamination level below the limit of detection. Co-occurrence of six mycotoxins was determined in 7% of the samples.
[Mh] Termos MeSH primário: Ração Animal/microbiologia
Micotoxinas/análise
Micotoxinas/biossíntese
Oncorhynchus mykiss
[Mh] Termos MeSH secundário: Ração Animal/efeitos adversos
Ração Animal/análise
Animais
Aquicultura
Aspergillus/química
Contagem de Colônia Microbiana
Eurotium/química
Contaminação de Alimentos
Microbiota
Penicillium/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Mycotoxins)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:151214
[Lr] Data última revisão:
151214
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151112
[St] Status:MEDLINE
[do] DOI:10.3390/toxins7114595


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[PMID]:26319723
[Au] Autor:Dagnas S; Gauvry E; Onno B; Membré JM
[Ad] Endereço:L'Université Nantes Angers Le Mans, Oniris, Nantes F-44322 cedex 3, France.
[Ti] Título:Quantifying Effect of Lactic, Acetic, and Propionic Acids on Growth of Molds Isolated from Spoiled Bakery Products.
[So] Source:J Food Prot;78(9):1689-98, 2015 Sep.
[Is] ISSN:1944-9097
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The combined effect of undissociated lactic acid (0 to 180 mmol/liter), acetic acid (0 to 60 mmol/liter), and propionic acid (0 to 12 mmol/liter) on growth of the molds Aspergillus niger, Penicillium corylophilum, and Eurotium repens was quantified at pH 3.8 and 25°C on malt extract agar acid medium. The impact of these acids on lag time for growth (λ) was quantified through a gamma model based on the MIC. The impact of these acids on radial growth rate (µ) was analyzed statistically through polynomial regression. Concerning λ, propionic acid exhibited a stronger inhibitory effect (MIC of 8 to 20 mmol/liter depending on the mold species) than did acetic acid (MIC of 23 to 72 mmol/liter). The lactic acid effect was null on E. repens and inhibitory on A. niger and P. corylophilum. These results were validated using independent sets of data for the three acids at pH 3.8 but for only acetic and propionic acids at pH 4.5. Concerning µ, the effect of acetic and propionic acids was slightly inhibitory for A. niger and P. corylophilum but was not significant for E. repens. In contrast, lactic acid promoted radial growth of all three molds. The gamma terms developed here for these acids will be incorporated in a predictive model for temperature, water activity, and acid. More generally, results for µ and λ will be used to identify and evaluate solutions for controlling bakery product spoilage.
[Mh] Termos MeSH primário: Ácido Acético/farmacologia
Contaminação de Alimentos/prevenção & controle
Ácido Láctico/farmacologia
Propionatos/farmacologia
[Mh] Termos MeSH secundário: Aspergillus niger/efeitos dos fármacos
Aspergillus niger/isolamento & purificação
Eurotium/efeitos dos fármacos
Eurotium/isolamento & purificação
Manipulação de Alimentos
Microbiologia de Alimentos
Concentração de Íons de Hidrogênio
Testes de Sensibilidade Microbiana
Penicillium/efeitos dos fármacos
Penicillium/isolamento & purificação
Esporos Fúngicos/efeitos dos fármacos
Esporos Fúngicos/isolamento & purificação
Temperatura Ambiente
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Propionates); 33X04XA5AT (Lactic Acid); JHU490RVYR (propionic acid); Q40Q9N063P (Acetic Acid)
[Em] Mês de entrada:1604
[Cu] Atualização por classe:161125
[Lr] Data última revisão:
161125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150831
[St] Status:MEDLINE
[do] DOI:10.4315/0362-028X.JFP-15-046


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[PMID]:25730346
[Au] Autor:Meng LH; Du FY; Li XM; Pedpradab P; Xu GM; Wang BG
[Ad] Endereço:†Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Nanhai Road 7, Qingdao 266071, People's Republic of China.
[Ti] Título:Rubrumazines A-C, Indolediketopiperazines of the Isoechinulin Class from Eurotium rubrum MA-150, a Fungus Obtained from Marine Mangrove-Derived Rhizospheric Soil.
[So] Source:J Nat Prod;78(4):909-13, 2015 Apr 24.
[Is] ISSN:1520-6025
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Three new indolediketopiperazine alkaloids of the isoechinulin type, rubrumazines A-C (1-3), each possessing an oxygenated prenyl group either at C-7 (1 and 2) or at C-5 (3), along with 13 related analogues (4-16), were isolated and identified from a culture extract of Eurotium rubrum MA-150, a fungus obtained from mangrove-derived rhizospheric soil collected from the Andaman Sea coastline, Thailand. Their structures were established by detailed interpretation of NMR spectroscopic and mass spectrometry data analysis. The structure and absolute configuration of compound 1 were confirmed by X-ray crystallographic analysis, thus providing the first characterized crystal structure of an isoechinulin-type alkaloid. All isolated compounds were evaluated for brine shrimp lethality and antibacterial activity.
[Mh] Termos MeSH primário: Eurotium/química
Alcaloides de Indol/isolamento & purificação
Rhizophoraceae/microbiologia
[Mh] Termos MeSH secundário: Animais
Cristalografia por Raios X
Alcaloides de Indol/química
Alcaloides de Indol/farmacologia
Biologia Marinha
Estrutura Molecular
Tailândia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Indole Alkaloids); 0 (rubrumazine A); 0 (rubrumazine B); 0 (rubrumazine C)
[Em] Mês de entrada:1509
[Cu] Atualização por classe:150424
[Lr] Data última revisão:
150424
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150303
[St] Status:MEDLINE
[do] DOI:10.1021/np5007839



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