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MEDLINE

seleciona para imprimir Fotocópia Alves, Tânia Maria de Almeida Zani, Carlos Leomar Texto completo SciELO Brasil

[PMID]: 29236928 [Au] Autor: Cota BB; Tunes LG; Maia DNB; Ramos JP; Oliveira DM; Kohlhoff M; Alves TMA; Souza-Fagundes EM; Campos FF; Zani CL [Ad] Endereço: Laboratório de Química de Produtos Naturais Bioativos, Instituto René Rachou, Fundação Oswaldo Cruz-Fiocruz, Belo Horizonte, MG, Brasil. [Ti] Título: Leishmanicidal compounds of Nectria pseudotrichia, an endophytic fungus isolated from the plant Caesalpinia echinata (Brazilwood). [So] Source: Mem Inst Oswaldo Cruz;113(2):102-110, 2018 Feb. [Is] ISSN: 1678-8060 [Cp] País de publicação: Brazil [La] Idioma: eng [Ab] Resumo: BACKGROUND In a screen of extracts from plants and fungi to detect antileishmanial activity, we found that the ethyl acetate extract of the fungus Nectria pseudotrichia, isolated from the tree Caesalpinia echinata (Brazilwood), is a promising source of bioactive compounds. OBJECTIVES The aims of this study were to isolate and determine the chemical structures of the compounds responsible for the antileishmanial activity of the organic extract from N. pseudotrichia. METHODS Compounds were isolated by chromatographic fractionation using semi-preparative high-performance liquid chromatography, and their chemical structures were determined by analytical and spectral data and by comparison with published data. The antileishmanial activity of the isolated compounds was evaluated in intracellular amastigote forms of Leishmania (Viannia) braziliensis expressing firefly luciferase as reporter gene, and cytotoxicity was determined in Vero and THP-1 mammalian cell lines by MTT assay. FINDINGS Fractionation of the extract yielded seven compounds: 10-acetyl trichoderonic acid A (1), 6'-acetoxy-piliformic acid (2), 5',6'-dehydropiliformic acid (3), piliformic acid (4), hydroheptelidic acid (5), xylaric acid D (6), and cytochalasin D (7). Compounds 1, 2 and 3 are reported here for the first time. Compounds 1, 2, and 5 were more active, with IC50 values of 21.4, 28.3, and 24.8 µM, respectively, and showed low toxicity to Vero and THP-1 cells. MAIN CONCLUSIONS N. pseudotrichia produces secondary metabolites that are more toxic to intracellular amastigote forms of L. (V.) braziliensis than to mammalian cells. [Mh] Termos MeSH primário: Caesalpinia/microbiologia Leishmania braziliensis/efeitos dos fármacos Nectria/química Tripanossomicidas/farmacologia [Mh] Termos MeSH secundário: Animais Sobrevivência Celular Cercopithecus aethiops Cromatografia Líquida de Alta Pressão Concentração Inibidora 50 Testes de Sensibilidade Parasitária Testes de Toxicidade Tripanossomicidas/isolamento & purificação Tripanossomicidas/toxicidade Células Vero [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Trypanocidal Agents) [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180215 [Lr] Data última revisão: 180215 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171214 [St] Status: MEDLINE

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MEDLINE

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[PMID]: 27136568 [Au] Autor: Cui H; Liu Y; Nie Y; Liu Z; Chen S; Zhang Z; Lu Y; He L; Huang X; She Z [Ad] Endereço: School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, China. cuihui2@mail2.sysu.edu.cn. [Ti] Título: Polyketides from the Mangrove-Derived Endophytic Fungus Nectria sp. HN001 and Their α-Glucosidase Inhibitory Activity. [So] Source: Mar Drugs;14(5), 2016 Apr 28. [Is] ISSN: 1660-3397 [Cp] País de publicação: Switzerland [La] Idioma: eng [Ab] Resumo: Four new polyketides: nectriacids A-C (1-3) and 12-epicitreoisocoumarinol (4), together with three known compounds: citreoisocoumarinol (5), citreoisocoumarin (6), and macrocarpon C (7) were isolated from the culture of the endophytic fungus Nectria sp. HN001, which was isolated from a fresh branch of the mangrove plant Sonneratia ovata collected from the South China Sea. Their structures were determined by the detailed analysis of NMR and mass spectroscopic data. The absolute configuration of the stereogenic carbons for compound 4 was further assigned by Mosher's ester method. All of the isolated compounds were tested for their α-glucosidase inhibitory activity by UV absorbance at 405 nm, and new compounds 2 and 3 exhibited potent inhibitory activity with IC50 values of 23.5 and 42.3 µM, respectively, which were more potent than positive control (acarbose, IC50, 815.3 µM). [Mh] Termos MeSH primário: Endófitos/química Fungos/química Inibidores de Glicosídeo Hidrolases/farmacologia Nectria/química Policetídeos/farmacologia Rhizophoraceae/microbiologia alfa-Glucosidases/metabolismo [Mh] Termos MeSH secundário: China Inibidores de Glicosídeo Hidrolases/química Concentração Inibidora 50 Espectroscopia de Ressonância Magnética/métodos Estrutura Molecular Policetídeos/química [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Glycoside Hydrolase Inhibitors); 0 (Polyketides); EC 3.2.1.20 (alpha-Glucosidases) [Em] Mês de entrada: 1705 [Cu] Atualização por classe: 170512 [Lr] Data última revisão: 170512 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 160503 [St] Status: MEDLINE

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MEDLINE

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[PMID]: 26399187 [Au] Autor: Garmaroodi HS; Taga M [Ad] Endereço: Graduate School of Natural Science and Technology, Okayama University, Tsushima-naka, Kita-ku, Okayama, 700-8530, Japan. Electronic address: hsgarmaroodi@spii.ir. [Ti] Título: Meiotic inheritance of a fungal supernumerary chromosome and its effect on sexual fertility in Nectria haematococca. [So] Source: Fungal Biol;119(10):929-39, 2015 Oct. [Is] ISSN: 1878-6146 [Cp] País de publicação: Netherlands [La] Idioma: eng [Ab] Resumo: PDA1-conditionally dispensable chromosome (CDC) of Nectria haematococca MP VI has long served as a model of supernumerary chromosomes in plant pathogenic fungi because of pathogenicity-related genes located on it. In our previous study, we showed the dosage effects of PDA1-CDC on pathogenicity and homoserine utilization by exploiting tagged PDA1-CDC with a marker gene. CDC content of mating partners and progenies analyzed by PCR, PFGE combined with Southern analysis and chromosome painting via FISH. In this study, we analyzed mode of meiotic inheritance of PDA1-CDC in several mating patterns with regard to CDC content and found a correlation between CDC content of parental strains with fertility of crosses. The results showed non-Mendelian inheritance of this chromosome followed by duplication or loss of the CDC in haploid genome through meiosis that probably were due to premature centromere division, not by nondisjunction as reported for the supernumerary chromosomes in other species. Correlation of CDC with fertility is the first time to be examined in fungi in this study. [Mh] Termos MeSH primário: Cromossomos Fúngicos Meiose Nectria/genética Nectria/fisiologia Poliploidia Testamentos [Mh] Termos MeSH secundário: Cruzamentos Genéticos [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Em] Mês de entrada: 1606 [Cu] Atualização por classe: 150924 [Lr] Data última revisão: 150924 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 150925 [St] Status: MEDLINE

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MEDLINE

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[PMID]: 26001271 [Au] Autor: Gong T; Zhen X; Li BJ; Yang JL; Zhu P [Ad] Endereço: a State Key Laboratory of Bioactive Substance and Function of Natural Medicines & Key Laboratory of Biosynthesis of Natural Products of the National Health and Family Planning Commission , Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College , Beijing 100050 , China. [Ti] Título: Two new monoterpenoid α-pyrones from a fungus Nectria sp. HLS206 associated with the marine sponge Gelliodes carnosa. [So] Source: J Asian Nat Prod Res;17(6):633-7, 2015. [Is] ISSN: 1477-2213 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Two new monoterpenoid α-pyrones, named nectriapyrones C and D (1 and 2), along with a known α-pyrone (nectriapyrone, 3) were isolated from a marine-derived fungus Nectria sp. HLS206 associated with the marine sponge Gelliodes carnosa collected from the South China Sea. Their structures were determined on the basis of 1D NMR, 2D NMR, HR-ESI-MS methods. [Mh] Termos MeSH primário: Monoterpenos/isolamento & purificação Nectria/química Poríferos/microbiologia Pironas/isolamento & purificação [Mh] Termos MeSH secundário: Animais Biologia Marinha Estrutura Molecular Monoterpenos/química Ressonância Magnética Nuclear Biomolecular Pironas/química [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (Monoterpenes); 0 (Pyrones); 0 (nectriapyrone C); 0 (nectriapyrone D) [Em] Mês de entrada: 1511 [Cu] Atualização por classe: 150803 [Lr] Data última revisão: 150803 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 150523 [St] Status: MEDLINE [do] DOI: 10.1080/10286020.2015.1040778

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MEDLINE

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[PMID]: 25652193 [Au] Autor: Veselá AB; Krenková A; Martínková L [Ad] Endereço: Laboratory of Biotransformation, Academy of Sciences of the Czech Republic, Vídenská 1083, 142 20, Prague, Czech Republic, vesela@biomed.cas.cz. [Ti] Título: Exploring the potential of fungal arylacetonitrilases in mandelic acid synthesis. [So] Source: Mol Biotechnol;57(5):466-74, 2015 May. [Is] ISSN: 1559-0305 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: The application of arylacetonitrilases from filamentous fungi to the hydrolysis of high concentrations of (R,S)-mandelonitrile (100-500 mM) was demonstrated for the first time. Escherichia coli strains expressing the corresponding genes were used as whole-cell catalysts. Nitrilases from Aspergillus niger, Neurospora crassa, Nectria haematococca, and Arthroderma benhamiae (enzymes NitAn, NitNc, NitNh, and NitAb, respectively) exhibited different degrees of enantio- and chemoselectivity (amide formation). Their enantio- and chemoselectivity was increased by increasing pH (from 8 to 9-10) and adding 4-10% (v/v) toluene as the cosolvent. NitAn and NitNc were able to convert an up to 500 mM substrate in batch mode. NitAn formed a very low amount of the by-product, amide (<1% of the total product). This enzyme produced up to >70 g/L of (R)-mandelic acid (e.e. 94.5-95.6%) in batch or fed-batch mode. Its volumetric productivities were the highest in batch mode [571 ± 32 g/(L d)] and its catalyst productivities in fed-batch mode (39.9 ± 2.5 g/g of dcw). NitAb hydrolyzed both enantiomers of 100 mM (R,S)-mandelonitrile at pH 5.0 and is therefore promising for the enantioretentive transformation of (S)-mandelonitrile. Sequence analysis suggested that fungal arylacetonitrilases with similar properties (enantioselectivity, chemoselectivity) were clustered together. [Mh] Termos MeSH primário: Aminoidrolases/química Aminoidrolases/metabolismo Ácidos Mandélicos/metabolismo [Mh] Termos MeSH secundário: Aminoidrolases/genética Arthrodermataceae/enzimologia Aspergillus niger/enzimologia Proteínas Fúngicas/química Proteínas Fúngicas/genética Proteínas Fúngicas/metabolismo Concentração de Íons de Hidrogênio Nectria/enzimologia Neurospora crassa/enzimologia Filogenia Especificidade da Espécie [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (Fungal Proteins); 0 (Mandelic Acids); EC 3.5.4.- (Aminohydrolases); NH496X0UJX (mandelic acid) [Em] Mês de entrada: 1603 [Cu] Atualização por classe: 171108 [Lr] Data última revisão: 171108 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 150206 [St] Status: MEDLINE [do] DOI: 10.1007/s12033-015-9840-y

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MEDLINE

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[PMID]: 25267157 [Au] Autor: Jiang J; Chen X; Zhang D; Wu Q; Zhu D [Ad] Endereço: National Engineering Laboratory for Industrial Enzymes and Tianjin Engineering Center for Biocatalytic Technology, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China. [Ti] Título: Characterization of (R)-selective amine transaminases identified by in silico motif sequence blast. [So] Source: Appl Microbiol Biotechnol;99(6):2613-21, 2015 Mar. [Is] ISSN: 1432-0614 [Cp] País de publicação: Germany [La] Idioma: eng [Ab] Resumo: Compared to (S)-selective amine transaminase ((S)-AT), the (R)-selective counterpart ((R)-AT) has been less studied. As such, a simplified "Motif Sequence Blast" search (Höhne et al. Nat Chem Biol 6:807-813, 2010) was carried out to identify new (R)-ATs from the protein databases. The combined conserved sequence motifs of (R)-ATs based on the previous in silico method of predicting (R)-selective amine transaminase were used as the template sequence for BLASTP search at default settings in NCBI, and six candidate sequences were identified. These putative (R)-AT genes were synthesized and overexpressed in Escherichia coli. Among them, five new (R)-ATs were expressed as soluble protein and showed unusual substrate specificity and high stereoselectivity. Furthermore, several unnatural amino acids, such as D-alanine, D-2-aminobutyric acid, and D-norvaline, were synthesized via the (R)-AT-catalyzed amino transfer reaction to the corresponding keto acids. Optically pure (S)-amines were also obtained by kinetic resolution of racemic amines catalyzed with these new (R)-ATs. Therefore, the Motif Sequence Blast search offers a quick and effective method for in silico identification of new (R)-ATs, and the newly identified (R)-ATs are attractive additions to the toolbox of (R)-ATs for further study and industrial application. [Mh] Termos MeSH primário: Transaminases/genética Transaminases/metabolismo [Mh] Termos MeSH secundário: Alanina/metabolismo Aminobutiratos/metabolismo Cordyceps/genética Cordyceps/metabolismo Bases de Dados de Proteínas Fusarium/genética Fusarium/metabolismo Cetoácidos/metabolismo Nectria/genética Nectria/metabolismo Estrutura Terciária de Proteína Especificidade por Substrato Trichoderma/genética Trichoderma/metabolismo Valina/análogos & derivados Valina/metabolismo [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (Aminobutyrates); 0 (Keto Acids); 8306QPJ19P (alpha-aminobutyric acid); A70UKS48FE (norvaline); EC 2.6.1.- (Transaminases); HG18B9YRS7 (Valine); OF5P57N2ZX (Alanine) [Em] Mês de entrada: 1602 [Cu] Atualização por classe: 150228 [Lr] Data última revisão: 150228 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 141001 [St] Status: MEDLINE [do] DOI: 10.1007/s00253-014-6056-1

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MEDLINE

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[PMID]: 25383531 [Au] Autor: Brunner JD; Lim NK; Schenck S; Duerst A; Dutzler R [Ad] Endereço: Department of Biochemistry, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland. [Ti] Título: X-ray structure of a calcium-activated TMEM16 lipid scramblase. [So] Source: Nature;516(7530):207-12, 2014 Dec 11. [Is] ISSN: 1476-4687 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: The TMEM16 family of proteins, also known as anoctamins, features a remarkable functional diversity. This family contains the long sought-after Ca(2+)-activated chloride channels as well as lipid scramblases and cation channels. Here we present the crystal structure of a TMEM16 family member from the fungus Nectria haematococca that operates as a Ca(2+)-activated lipid scramblase. Each subunit of the homodimeric protein contains ten transmembrane helices and a hydrophilic membrane-traversing cavity that is exposed to the lipid bilayer as a potential site of catalysis. This cavity harbours a conserved Ca(2+)-binding site located within the hydrophobic core of the membrane. Mutations of residues involved in Ca(2+) coordination affect both lipid scrambling in N. haematococca TMEM16 and ion conduction in the Cl(-) channel TMEM16A. The structure reveals the general architecture of the family and its mode of Ca(2+) activation. It also provides insight into potential scrambling mechanisms and serves as a framework to unravel the conduction of ions in certain TMEM16 proteins. [Mh] Termos MeSH primário: Cálcio/metabolismo Canais de Cloreto/química Canais de Cloreto/metabolismo Nectria/química Proteínas de Transferência de Fosfolipídeos/química Proteínas de Transferência de Fosfolipídeos/metabolismo [Mh] Termos MeSH secundário: Sequência de Aminoácidos Animais Anoctamina-1 Sítios de Ligação/genética Cálcio/química Cálcio/farmacologia Canais de Cloreto/genética Cristalografia por Raios X Condutividade Elétrica Seres Humanos Interações Hidrofóbicas e Hidrofílicas Transporte de Íons/efeitos dos fármacos Bicamadas Lipídicas/química Bicamadas Lipídicas/metabolismo Modelos Moleculares Dados de Sequência Molecular Nectria/enzimologia Nectria/genética Proteínas de Neoplasias/química Proteínas de Transferência de Fosfolipídeos/genética Multimerização Proteica Estrutura Secundária de Proteína Subunidades Proteicas/química Subunidades Proteicas/metabolismo [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (ANO1 protein, human); 0 (Anoctamin-1); 0 (Chloride Channels); 0 (Lipid Bilayers); 0 (Neoplasm Proteins); 0 (Phospholipid Transfer Proteins); 0 (Protein Subunits); SY7Q814VUP (Calcium) [Em] Mês de entrada: 1501 [Cu] Atualização por classe: 171116 [Lr] Data última revisão: 171116 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 141111 [St] Status: MEDLINE [do] DOI: 10.1038/nature13984

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MEDLINE

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[PMID]: 25272229 [Au] Autor: Li S; Nie Y; Ding Y; Shi L; Tang X [Ad] Endereço: Institute of Agro-products Processing Science and Technology, Chinese Academy of Agricultural Sciences (CAAS), Key Laboratory of Agro-products Processing, Ministry of Agriculture, No. 2 Yuan Ming Yuan West Road, Beijing 100193, China. lishuying2000@163.com. [Ti] Título: Recombinant expression of a novel fungal immunomodulatory protein with human tumor cell antiproliferative activity from Nectria haematococca. [So] Source: Int J Mol Sci;15(10):17751-64, 2014 Sep 30. [Is] ISSN: 1422-0067 [Cp] País de publicação: Switzerland [La] Idioma: eng [Ab] Resumo: To our best knowledge, all of the fungal immunomodulatory proteins (FIPs) have been successfully extracted and identified in Basidomycetes, with only the exception of FIP from ascomycete Nectria haematococca (FIP-nha) discovered through homology alignment most recently. In this work, a gene encoding FIP-nha was synthesized and recombinantly expressed in an Escherichia coli expression system. SDS-PAGE and MALDI-MS analyses of recombinant FIP-nha (rFIP-nha) indicated that the gene was successfully expressed. The yield of the bioactive FIP-nha protein was 42.7 mg/L. In vitro assays of biological activity indicated that the rFIP-nha caused hemagglutination of human and rabbit red blood cells, signiï¬�cantly stimulated mouse spleen lymphocyte proliferation, and enhanced expression of interleukin-2 (IL-2) released from mouse splenocytes, revealing a strong antitumor effect against HL60, HepG2 and MGC823. Through this work, we constructed a rapid and efficient method of FIP production, and suggested that FIP-nha is a valuable candidate for use in future medical care and pharmaceutical products. [Mh] Termos MeSH primário: Proteínas Fúngicas/metabolismo Nectria/metabolismo [Mh] Termos MeSH secundário: Animais Apoptose/efeitos dos fármacos Linhagem Celular Tumoral Proliferação Celular/efeitos dos fármacos Eritrócitos/citologia Eritrócitos/efeitos dos fármacos Escherichia coli/metabolismo Proteínas Fúngicas/genética Proteínas Fúngicas/farmacologia Células HL-60 Hemaglutinação/efeitos dos fármacos Células Hep G2 Seres Humanos Interleucina-2/metabolismo Camundongos Camundongos Endogâmicos BALB C Coelhos Proteínas Recombinantes/biossíntese Proteínas Recombinantes/isolamento & purificação Proteínas Recombinantes/farmacologia Baço/citologia Baço/efeitos dos fármacos Baço/metabolismo [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (Fungal Proteins); 0 (Interleukin-2); 0 (Recombinant Proteins) [Em] Mês de entrada: 1506 [Cu] Atualização por classe: 170220 [Lr] Data última revisão: 170220 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 141002 [St] Status: MEDLINE [do] DOI: 10.3390/ijms151017751

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MEDLINE

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[PMID]: 24618038 [Au] Autor: Sayer C; Martinez-Torres RJ; Richter N; Isupov MN; Hailes HC; Littlechild JA; Ward JM [Ad] Endereço: Henry Wellcome Building for Biocatalysis, College of Life and Environmental Sciences, University of Exeter, EX4 4QD, UK. [Ti] Título: The substrate specificity, enantioselectivity and structure of the (R)-selective amine : pyruvate transaminase from Nectria haematococca. [So] Source: FEBS J;281(9):2240-53, 2014 May. [Is] ISSN: 1742-4658 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: UNLABELLED: During the last decade the use of transaminases for the production of pharmaceutical and fine chemical intermediates has attracted a great deal of attention. Transaminases are versatile biocatalysts for the efficient production of amine intermediates and many have (S)-enantiospecificity. Transaminases with (R)-specificity are needed to expand the applications of these enzymes in biocatalysis. In this work we have identified a fungal putative (R)-specific transaminase from the Eurotiomycetes Nectria haematococca, cloned a synthetic version of this gene, demonstrated (R)-selective deamination of several substrates including (R)-α-methylbenzylamine, as well as production of (R)-amines, and determined its crystal structure. The crystal structures of the holoenzyme and the complex with an inhibitor gabaculine offer the first detailed insight into the structural basis for substrate specificity and enantioselectivity of the industrially important class of (R)-selective amine : pyruvate transaminases. DATABASE: The atomic coordinates and structure factors for the Nectria TAm in holoenzyme and gabaculine-bound forms have been deposited in the PDB as entries 4cmd and 4cmf respectively. [Mh] Termos MeSH primário: Nectria/enzimologia Transaminases/metabolismo [Mh] Termos MeSH secundário: Sequência de Aminoácidos Biocatálise Clonagem Molecular Genes Fúngicos Modelos Moleculares Dados de Sequência Molecular Nectria/genética Conformação Proteica Estereoisomerismo Especificidade por Substrato Transaminases/química Transaminases/genética [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: EC 2.6.1.- (Transaminases) [Em] Mês de entrada: 1406 [Cu] Atualização por classe: 161019 [Lr] Data última revisão: 161019 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 140313 [St] Status: MEDLINE [do] DOI: 10.1111/febs.12778

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[PMID]: 23652606 [Au] Autor: Kawahara T; Itoh M; Izumikawa M; Sakata N; Tsuchida T; Shin-ya K [Ad] Endereço: Japan Biological Informatics Consortium (JBIC), Tokyo, Japan. [Ti] Título: Cytotoxic sesquiterpenoids MBJ-0009 and MBJ-0010 from a saprobic fungus Nectria sp. f26111. [So] Source: J Antibiot (Tokyo);66(9):567-9, 2013 Sep. [Is] ISSN: 0021-8820 [Cp] País de publicação: Japan [La] Idioma: eng [Mh] Termos MeSH primário: Antineoplásicos/farmacologia Nectria/química Sesquiterpenos/farmacologia [Mh] Termos MeSH secundário: Antineoplásicos/química Antineoplásicos/isolamento & purificação Linhagem Celular Tumoral Sobrevivência Celular/efeitos dos fármacos Seres Humanos Japão Espectroscopia de Ressonância Magnética Modelos Moleculares Estrutura Molecular Nectria/isolamento & purificação Sesquiterpenos/química Sesquiterpenos/isolamento & purificação Microbiologia do Solo [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (Antineoplastic Agents); 0 (Sesquiterpenes) [Em] Mês de entrada: 1311 [Cu] Atualização por classe: 130927 [Lr] Data última revisão: 130927 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 130509 [St] Status: MEDLINE [do] DOI: 10.1038/ja.2013.45

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BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde