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  1 / 1952 MEDLINE  
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[PMID]:29220431
[Au] Autor:Franco ME; Bitencourt TA; Marins M; Fachin AL
[Ad] Endereço:Unidade de Biotecnologia, Universidade de Ribeirão Preto, Av: Costabile Romano 2201, 14096-900, Ribeirao Preto SP, Brazil.
[Ti] Título:In silico characterization of tandem repeats in Trichophyton rubrum and related dermatophytes provides new insights into their role in pathogenesis.
[So] Source:Database (Oxford);2017, 2017 Jan 01.
[Is] ISSN:1758-0463
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Database URL: http://comp.mch.ifsuldeminas.edu.br/dtrdb/.
[Mh] Termos MeSH primário: Arthrodermataceae
DNA Fúngico/genética
Bases de Dados Genéticas
Sequências de Repetição em Tandem/genética
Trichophyton
[Mh] Termos MeSH secundário: Animais
Arthrodermataceae/genética
Arthrodermataceae/patogenicidade
Simulação por Computador
Dermatomicoses/microbiologia
Seres Humanos
Internet
Trichophyton/genética
Trichophyton/patogenicidade
Interface Usuário-Computador
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Fungal)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171209
[St] Status:MEDLINE
[do] DOI:10.1093/database/bax035


  2 / 1952 MEDLINE  
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[PMID]:29388537
[Au] Autor:Carreira A; Ferreira JB; Pereira I; Ferreira J; Filipe P; Ferreira RB; Monteiro S
[Ad] Endereço:1​CEV, SA, Parque Industrial de Cantanhede/Biocant-Park, lote 120, 3060-197 Cantanhede, Portugal.
[Ti] Título:Blad-containing oligomer: a novel fungicide used in crop protection as an alternative treatment for tinea pedis and tinea versicolor.
[So] Source:J Med Microbiol;67(2):198-207, 2018 Feb.
[Is] ISSN:1473-5644
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:PURPOSE: The lack of novel antifungal drugs and the increasing incidence and severity of fungal infections are major concerns worldwide. Herein, we tested the activity of the Blad-containing oligomer (BCO), a new antifungal molecule already in use for agriculture, on Malassezia spp. and dermatophytes, the causal agents of human tinea versicolor and tinea pedis. Given the lack of a standard method for Malassezia susceptibility testing and the plethora of published methods, we also developed an improved method for this genus. METHODOLOGY: The efficacy of BCO was assessed in vitro and compared to that of the drugs currently utilized in the treatment of tinea versicolor (fluconazole and itraconazole) and tinea pedis (itraconazole and terbinafine). For dermatophytes, the standard microdilution broth-based method was used, with small adjustments, and several broth formulations and inocula sizes were tested to develop an improved susceptibility method for Malassezia spp. RESULTS: We successfully developed a microdilution broth-based method with considerable advantages over other available methods, and used it for all in vitro susceptibility tests of Malassezia spp. isolates. We report that, on a molar basis, BCO was more effective than fluconazole or itraconazole on most strains of Malassezia spp. isolated from clinical samples (n=29). By contrast, BCO was less effective than itraconazole or terbinafine on the common dermatophytes Trichophyton rubrum and Trichophyton interdigitale. CONCLUSION: These data place BCO as a promising drug for the treatment of Malassezia-associated skin diseases. Further in vivo studies are now required to ascertain its applicability in the clinical setting.
[Mh] Termos MeSH primário: Antifúngicos/farmacologia
Arthrodermataceae/efeitos dos fármacos
Fungicidas Industriais/farmacologia
Malassezia/efeitos dos fármacos
Tinha dos Pés/tratamento farmacológico
Tinha Versicolor/tratamento farmacológico
[Mh] Termos MeSH secundário: Antifúngicos/uso terapêutico
Proteção de Cultivos
Descoberta de Drogas
Fluconazol/farmacologia
Fungicidas Industriais/uso terapêutico
Seres Humanos
Itraconazol/farmacologia
Testes de Sensibilidade Microbiana
Tinha dos Pés/microbiologia
Tinha Versicolor/microbiologia
Trichophyton/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (Fungicides, Industrial); 304NUG5GF4 (Itraconazole); 8VZV102JFY (Fluconazole)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180206
[Lr] Data última revisão:
180206
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180202
[St] Status:MEDLINE
[do] DOI:10.1099/jmm.0.000675


  3 / 1952 MEDLINE  
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[PMID]:28566667
[Au] Autor:Tsunemi Y
[Ad] Endereço:Department of Dermatology, Tokyo Women's Medical University.
[Ti] Título:Dermatophyte Antigen Kit.
[So] Source:Med Mycol J;58(2):J51-J54, 2017.
[Is] ISSN:1882-0476
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:The dermatophyte antigen kit uses monoclonal antibodies that react with polysaccharides present in the dermatophyte cell wall to detect dermatophyte antigens in specimens based on the principle of immunochromatography. Clinical studies showed that the kit was very useful in the diagnosis of tinea unguium but not tinea pedis. The kit was therefore further developed as an in vitro diagnostic tool for tinea unguium and was approved by the Pharmaceuticals and Medical Devices Agency of Japan. The kit's extraction solution can extract antigens from nail specimens quickly and efficiently. When direct microscopy fails to detect fungal elements in a specimen of suspected tinea unguium, the kit can be used so that positive samples are re-examined by direct microscopy, in order to reduce the likelihood of false-negative detection. In addition, in settings where direct microscopy is unavailable, the kit can be used so that treatment for dermatophytes is withheld when results are negative. Such an approach can reduce both wasteful treatment and medical costs. It is important to note that the kit is used to complement conventional fungus testing methods and that direct microscopy must be used to confirm the final morphological diagnosis of the pathogenic fungal infection. Use of a combination of direct microscopy and this kit should improve the accuracy of diagnosis of tinea unguium.
[Mh] Termos MeSH primário: Arthrodermataceae/imunologia
Onicomicose/diagnóstico
Kit de Reagentes para Diagnóstico
[Mh] Termos MeSH secundário: Anticorpos Monoclonais
Antígenos de Fungos/imunologia
Antígenos de Fungos/isolamento & purificação
Arthrodermataceae/patogenicidade
Arthrodermataceae/ultraestrutura
Reações Falso-Negativas
Polissacarídeos Fúngicos/imunologia
Seres Humanos
Imunocromatografia
Microscopia
Onicomicose/diagnóstico por imagem
Onicomicose/microbiologia
Sensibilidade e Especificidade
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Antibodies, Monoclonal); 0 (Antigens, Fungal); 0 (Fungal Polysaccharides); 0 (Reagent Kits, Diagnostic)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171015
[Lr] Data última revisão:
171015
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170602
[St] Status:MEDLINE
[do] DOI:10.3314/mmj.17.005


  4 / 1952 MEDLINE  
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[PMID]:28524381
[Au] Autor:Li ZJ; Liu M; Dawuti G; Dou Q; Ma Y; Liu HG; Aibai S
[Ad] Endereço:Department of Pharmacology and Toxicology Laboratory, Xinjiang Institute of Traditional Uighur Medicine, Xinjiang Laboratory of Uighur Medical Prescription, Urumqi, Xinjiang, 830049, China.
[Ti] Título:Antifungal Activity of Gallic Acid In Vitro and In Vivo.
[So] Source:Phytother Res;31(7):1039-1045, 2017 Jul.
[Is] ISSN:1099-1573
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Gallic acid (GA) is a polyphenol natural compound found in many medicinal plant species, including pomegranate rind (Punica granatum L.), and has been shown to have antiinflammatory and antibacterial properties. Pomegranate rind is used to treat bacterial and fungal pathogens in Uyghur and other systems of traditional medicine, but, surprisingly, the effects of GA on antifungal activity have not yet been reported. In this study, we aimed to investigate the inhibitory effects of GA on fungal strains both in vitro and in vivo. The minimal inhibitory concentration (MIC) was determined by the NCCLS (M38-A and M27-A2) standard method in vitro, and GA was found to have a broad spectrum of antifungal activity, with MICs for all the tested dermatophyte strains between 43.75 and 83.33 µg/mL. Gallic acid was also active against three Candida strains, with MICs between 12.5 and 100.0 µg/mL. The most sensitive Candida species was Candida albicans (MIC = 12.5 µg/mL), and the most sensitive filamentous species was Trichophyton rubrum (MIC = 43.75 µg/mL), which was comparable in potency to the control, fluconazole. The mechanism of action was investigated for inhibition of ergosterol biosynthesis using an HPLC-based assay and an enzyme linked immunosorbent assay. Gallic acid reduced the activity of sterol 14α-demethylase P450 (CYP51) and squalene epoxidase in the T. rubrum membrane, respectively. In vivo model demonstrated that intraperitoneal injection administration of GA (80 mg/kg d) significantly enhanced the cure rate in a mice infection model of systemic fungal infection. Overall, our results confirm the antifungal effects of GA and suggest a mechanism of action, suggesting that GA has the potential to be developed further as a natural antifungal agent for clinical use. Copyright © 2017 John Wiley & Sons, Ltd.
[Mh] Termos MeSH primário: Antifúngicos/farmacologia
Arthrodermataceae/efeitos dos fármacos
Ácido Gálico/farmacologia
[Mh] Termos MeSH secundário: Animais
Candida/efeitos dos fármacos
Candidíase/tratamento farmacológico
Feminino
Fluconazol/farmacologia
Masculino
Camundongos Endogâmicos ICR
Testes de Sensibilidade Microbiana
Trichophyton/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifungal Agents); 632XD903SP (Gallic Acid); 8VZV102JFY (Fluconazole)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171004
[Lr] Data última revisão:
171004
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170520
[St] Status:MEDLINE
[do] DOI:10.1002/ptr.5823


  5 / 1952 MEDLINE  
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[PMID]:28236353
[Au] Autor:Gnat S; Nowakiewicz A; Ziólkowska G; Troscianczyk A; Majer-Dziedzic B; Zieba P
[Ad] Endereço:Sub-Department of Veterinary Microbiology, Institute of Biological Bases of Animal Diseases, Faculty of Veterinary Medicine, University of Life Sciences, Lublin, Poland.
[Ti] Título:Evaluation of growth conditions and DNA extraction techniques used in the molecular analysis of dermatophytes.
[So] Source:J Appl Microbiol;122(5):1368-1379, 2017 May.
[Is] ISSN:1365-2672
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:AIMS: Recent molecular methods for diagnosis of superficial mycoses have determined the need for a rapid and easy method of extracting DNA. The aim of study was to determine growth conditions and techniques of DNA extraction for Microsporum canis, Trichophyton mentagrophytes and T. verrucosum. METHODS AND RESULTS: Samples were prepared of each of the DNA extraction methods (phenol-chloroform, CTAB and four different kits) for all of the incubation periods (4, 7 and 10 days) of the cultures on the solid and in the liquid medium. The highest DNA concentrations were obtained using the phenol-chloroform method. The concentration of DNA extracted with the CTAB method accounted for 62·21%, for kits it corresponded from 35·53 to 15·41%. The analysis of the DNA weight yield revealed the highest isolation efficiency of the phenol-chloroform method, 1 mg of mycelium yielded 223·8 µg DNA. Lower DNA yield (by 39·32%) was obtained with the CTAB method; in the case of kits by 68·46-85·32%. In most of the techniques, the DNA yield on the solid medium was higher. CONCLUSION: In summary, the highest DNA yield was noted in the 7-day cultures and extraction with the phenol-chloroform method. Importantly, the type of culture was not relevant for the diagnostic result. SIGNIFICANCE AND IMPACT OF THE STUDY: Most mycoses are caused by fungi that reside in nature. The severity of the infection depends on the pathogenic attributes, socioeconomic factors and local environmental conditions. Recent diagnosis increasingly relies on not only the clinical features. Molecular identifications have determined the need for a rapid and easy method of extracting DNA. Usually two factors have to be considered: maximize the DNA yield and ensure that the extracted DNA is susceptible to enzymatic reactions. These data suggest that phenol-chloroform methods and a 7-day culture period may be useful for validation and constitute the first step of molecular diagnosis of dermatophytes.
[Mh] Termos MeSH primário: Arthrodermataceae/crescimento & desenvolvimento
Arthrodermataceae/genética
Fracionamento Químico/métodos
DNA Fúngico/isolamento & purificação
Dermatomicoses/microbiologia
[Mh] Termos MeSH secundário: Arthrodermataceae/classificação
Arthrodermataceae/isolamento & purificação
DNA Fúngico/genética
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Fungal)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170703
[Lr] Data última revisão:
170703
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170226
[St] Status:MEDLINE
[do] DOI:10.1111/jam.13427


  6 / 1952 MEDLINE  
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[PMID]:28220547
[Au] Autor:Koc AN; Atalay MA; Inci M; Sariguzel FM; Sav H
[Ad] Endereço:Department of Microbiology, Erciyes University Medical Faculty, Kayseri, Turkey.
[Ti] Título:Identification and molecular epidemiology of dermatophyte isolates by repetitive-sequence-PCR-based DNA fingerprinting using the DiversiLab system in Turkey.
[So] Source:Mycoses;60(5):348-354, 2017 May.
[Is] ISSN:1439-0507
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Dermatophyte species, isolation and identification in clinical samples are still difficult and take a long time. The identification and molecular epidemiology of dermatophytes commonly isolated in a clinical laboratory in Turkey by repetitive sequence-based PCR (rep-PCR) were assessed by comparing the results with those of reference identification. A total of 44 dermatophytes isolated from various clinical specimens of 20 patients with superficial mycoses in Kayseri and 24 patients in Hatay were studied. The identification of dermatophyte isolates was based on the reference identification and rep-PCR using the DiversiLab System (BioMerieux). The genotyping of dermatophyte isolates from different patients was determined by rep-PCR. In the identification of dermatophyte isolates, agreement between rep-PCR and conventional methods was 87.8 % ( 36 of 41). The dermatophyte strains belonged to four clones (A -D) which were determined by the use of rep-PCR. The dermatophyte strains in Clone B, D showed identical patterns with respect to the region. In conclusion, rep-PCR appears to be useful for evaluation of the identification and clonal relationships between Trichophyton rubrum species complex and Trichophyton mentagrophytes species complex isolates. The similarity and diversity of these isolates may be assessed according to different regions by rep-PCR.
[Mh] Termos MeSH primário: Arthrodermataceae/genética
Impressões Digitais de DNA/métodos
DNA Fúngico/genética
Dermatomicoses/epidemiologia
Genótipo
Trichophyton/genética
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Arthrodermataceae/classificação
Arthrodermataceae/isolamento & purificação
Criança
Dermatomicoses/diagnóstico
Dermatomicoses/microbiologia
Feminino
Seres Humanos
Masculino
Meia-Idade
Reação em Cadeia da Polimerase/métodos
Análise de Sequência de DNA
Trichophyton/classificação
Turquia/epidemiologia
Adulto Jovem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Fungal)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170424
[Lr] Data última revisão:
170424
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170222
[St] Status:MEDLINE
[do] DOI:10.1111/myc.12602


  7 / 1952 MEDLINE  
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[PMID]:28138872
[Au] Autor:Bouchara JP; Mignon B; Chaturvedi V
[Ad] Endereço:UNIV Bretagne-Loire, University of Angers, University of Brest, Host-Pathogen Interactions Study Group (EA 3142), Angers, France.
[Ti] Título:Dermatophytes and Dermatophytoses: A Thematic Overview of State of the Art, and the Directions for Future Research and Developments.
[So] Source:Mycopathologia;182(1-2):1-4, 2017 Feb.
[Is] ISSN:1573-0832
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Mh] Termos MeSH primário: Arthrodermataceae/isolamento & purificação
Tinha/diagnóstico
Tinha/tratamento farmacológico
[Mh] Termos MeSH secundário: Animais
Antifúngicos/isolamento & purificação
Antifúngicos/farmacologia
Antifúngicos/uso terapêutico
Arthrodermataceae/classificação
Arthrodermataceae/patogenicidade
Pesquisa Biomédica/tendências
Interações Hospedeiro-Patógeno
Seres Humanos
Tinha/epidemiologia
Tinha/microbiologia
[Pt] Tipo de publicação:EDITORIAL
[Nm] Nome de substância:
0 (Antifungal Agents)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170201
[St] Status:MEDLINE
[do] DOI:10.1007/s11046-017-0114-z


  8 / 1952 MEDLINE  
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[PMID]:27878642
[Au] Autor:Heinen MP; Cambier L; Fievez L; Mignon B
[Ad] Endereço:Veterinary Mycology, Fundamental and Applied Research for Animals & Health (FARAH), Faculty of Veterinary Medicine, University of Liège, Quartier Vallée 2, Avenue de Cureghem 6, B-43a, 4000, Liège, Belgium.
[Ti] Título:Are Th17 Cells Playing a Role in Immunity to Dermatophytosis?
[So] Source:Mycopathologia;182(1-2):251-261, 2017 Feb.
[Is] ISSN:1573-0832
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Despite their superficial localization in the skin, pathogenic dermatophytes can induce a complex but still misunderstood immune response in their hosts. The cell-mediated immunity (CMI) is correlated with both clinical recovery and protection against reinfection, and CD4+ T lymphocytes have been recognized as a crucial component of the immune defense against dermatophytes. Before the discovery of the Th17 pathway, CMI was considered to be only dependent of Th1 cells, and thus most studies on the immunology of dermatophytosis have focused on the Th1 pathway. Nevertheless, the fine comparative analysis of available scientific data on immunology of dermatophytosis in one hand and on the Th17 pathway mechanisms involved in opportunistic mucosal fungal infections in the other hand reveals that some key elements of the Th17 pathway can be activated by dermatophytes. Stimulation of the Th17 pathway could occur through the activation of some C-type lectin-like receptors and inflammasome in antigen-presenting cells. The Th17 cells could go back to the affected skin and by the production of signature cytokines could induce the effector mechanisms like the recruitment of polymorphonuclear neutrophils and the synthesis of antimicrobial peptides. In conclusion, besides the Th1 pathway, which is important to the immune response against dermatophytes, there are also growing evidences for the involvement of the Th17 pathway.
[Mh] Termos MeSH primário: Imunidade Adaptativa
Arthrodermataceae/imunologia
Imunidade Inata
Células Th17/imunologia
Tinha/imunologia
[Mh] Termos MeSH secundário: Animais
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1704
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161124
[St] Status:MEDLINE
[do] DOI:10.1007/s11046-016-0093-5


  9 / 1952 MEDLINE  
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[PMID]:27876749
[Au] Autor:Cavalcante CS; Falcão CB; Fontenelle RO; Andreu D; Rádis-Baptista G
[Ad] Endereço:Postgraduate Program in Pharmaceutical Sciences, Faculty of Pharmacy, Dentistry and Nursing, Federal University of Ceará, Ceará, Brazil.
[Ti] Título:Anti-fungal activity of Ctn[15-34], the C-terminal peptide fragment of crotalicidin, a rattlesnake venom gland cathelicidin.
[So] Source:J Antibiot (Tokyo);70(3):231-237, 2017 Mar.
[Is] ISSN:0021-8820
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Crotalicidin (Ctn), a 34-residue cathelicidin from a South American rattlesnake, and its fragment (Ctn[15-34]) have shown anti-infective and cytotoxic activities against Gram-negative bacteria and certain tumor lines, respectively. The extent of such effects has been related to physicochemical characteristics such as helicity and hydrophobicity. We now report the anti-fungal activity of Ctn and its fragments (Ctn[1-14]) and (Ctn[15-34]). MIC determination and luminescent cell viability assays were used to evaluate the anti-infective activity of Ctn and its fragments (Ctn[1-14]) and (Ctn[15-34]) as anti-fungal agents against opportunistic yeast and dermatophytes. Cytotoxicity towards healthy eukaryotic cells was assessed in vitro with healthy human kidney-2 (HK-2) cells and erythrocytes. The checkerboard technique was performed to estimate the effects of combining either one of the peptides with amphotericin B. Ctn was the most active peptide against dermatophytes and also the most toxic to healthy eukaryotic cells. Fragments Ctn[1-14] and Ctn[15-35] lost activity against dermatophytes, but became more active against pathogenic yeasts, including several Candida species, both clinical isolates and standard strains, with MICs as low as 5 µm. Interestingly, the two peptide fragments were less cytotoxic to healthy HK-2 cells and less hemolytic to human erythrocytes than the standard-of-care amphotericin B. Also noteworthy was the synergy between Ctn peptides and amphotericin B, with consequent reduction in MICs of both drug and peptides. Altogether, Ctn and its fragments, particularly Ctn[15-34], are promising leads, either alone or in combined regimen with amphotericin B, for the treatment of fungal diseases.
[Mh] Termos MeSH primário: Antifúngicos/farmacologia
Peptídeos Catiônicos Antimicrobianos/farmacologia
Venenos de Crotalídeos/química
Fragmentos de Peptídeos/farmacologia
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Anfotericina B/farmacologia
Peptídeos Catiônicos Antimicrobianos/química
Arthrodermataceae/efeitos dos fármacos
Candida albicans/efeitos dos fármacos
Linhagem Celular
Sobrevivência Celular/efeitos dos fármacos
Farmacorresistência Fúngica
Sinergismo Farmacológico
Eritrócitos/efeitos dos fármacos
Hemólise/efeitos dos fármacos
Seres Humanos
Técnicas In Vitro
Testes de Sensibilidade Microbiana
Fragmentos de Peptídeos/química
Leveduras/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (Antimicrobial Cationic Peptides); 0 (Crotalid Venoms); 0 (Peptide Fragments); 0 (crotalicidin); 143108-26-3 (CAP18 lipopolysaccharide-binding protein); 7XU7A7DROE (Amphotericin B)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170505
[Lr] Data última revisão:
170505
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161124
[St] Status:MEDLINE
[do] DOI:10.1038/ja.2016.135


  10 / 1952 MEDLINE  
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[PMID]:27866353
[Au] Autor:de Matos RF; Mendonça LCV; da Silva Souza KG; Fonseca AAD; Costa EMS; de Lima MVD; Vieira JMDS; de Brito MTFM; Monteiro MC
[Ad] Endereço:Programa de Pós-graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal do Pará/UFPA, Rua Augusto Corrêa, 01, Bairro Guamá, Belém, PA, 66075-110, Brazil.
[Ti] Título:Nimesulide inhibits pathogenic fungi: PGE2-dependent mechanisms.
[So] Source:Folia Microbiol (Praha);62(2):169-174, 2017 Mar.
[Is] ISSN:1874-9356
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Certain non-steroidal anti-inflammatory drugs can inhibit fungal growth, fungal prostaglandin E2 production, and enzyme activation. This study aims to investigate the antifungal effect of nimesulide against pathogenic filamentous fungi and yeast. The experiments detailed below were also designed to investigate whether the action is dependent on E2 fungal prostaglandins. Our data showed that nimesulide exhibited potent antifungal activity, mainly against Trichophyton mentagrophytes (ATCC 9533) and Cryptococcus neoformans with MIC values of 2 and 62 µg/mL, respectively. This drug was also able to inhibit the growth of clinic isolates of filamentous fungi, such as Aspergillus fumigatus, and dermatophytes, such as T. rubrum, T. mentagrophytes, Epidermophyton floccosum, Microsporum canis, and M. gypseum, with MIC values ranging from 112 to 770 µg/mL. Our data also showed that the inhibition of fungal growth by nimesulide was mediated by a mechanism dependent on PGE2, which led to the inhibition of essential fungal enzymes. Thus, we concluded that nimesulide exerts a fungicidal effect against pathogenic filamentous fungi and yeast, involving the inhibition of fungal prostaglandins and fungal enzymes important to the fungal growth and colonization.
[Mh] Termos MeSH primário: Antifúngicos/farmacologia
Cryptococcus neoformans/efeitos dos fármacos
Dinoprostona/antagonistas & inibidores
Sulfonamidas/farmacologia
Trichophyton/efeitos dos fármacos
[Mh] Termos MeSH secundário: Arthrodermataceae/efeitos dos fármacos
Arthrodermataceae/crescimento & desenvolvimento
Arthrodermataceae/metabolismo
Aspergillus fumigatus/efeitos dos fármacos
Aspergillus fumigatus/crescimento & desenvolvimento
Aspergillus fumigatus/metabolismo
Cryptococcus neoformans/crescimento & desenvolvimento
Cryptococcus neoformans/metabolismo
Dinoprostona/biossíntese
Testes de Sensibilidade Microbiana
Trichophyton/crescimento & desenvolvimento
Trichophyton/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (Sulfonamides); K7Q1JQR04M (Dinoprostone); V4TKW1454M (nimesulide)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:171109
[Lr] Data última revisão:
171109
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161121
[St] Status:MEDLINE
[do] DOI:10.1007/s12223-016-0483-6



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