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Referências encontradas : 23 [refinar]
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  1 / 23 MEDLINE  
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[PMID]:28482319
[Au] Autor:Giordani P; Minganti V; Brignole D; Malaspina P; Cornara L; Drava G
[Ad] Endereço:Università degli Studi di Genova, Dipartimento di Farmacia, Viale Cembrano 4, I-16148 Genova, Italy. Electronic address: giordani@difar.unige.it.
[Ti] Título:Is there a risk of trace element contamination in herbal preparations? A test study on the lichen Cetraria islandica.
[So] Source:Chemosphere;181:778-785, 2017 Aug.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Lichens are a source of unique secondary metabolites, which have been proved to have many biological properties with possible pharmaceutical roles, including e.g. antioxidant, antimicrobial, antifungal or anti-inflammatory activities and to be worth of consideration for potential human use. However, lichens lack cuticolar tissues and are exposed to several atmospheric contaminants, including trace elements. This work aims at exploring the potential toxicity of herbal preparations derived by the lichen Cetraria islandica due to trace element contamination, testing whether different concentrations may be observed, depending on the origin of the raw material. Fourteen samples of C. islandica, as cut dried thalli occurring on the European market, have been bought from different providers. For each sample, the concentrations of As, Cd, Co, Cu, Fe, Mn, Ni, P, Pb, V and Zn were measured on comminuted herbal substance and on the corresponding decoction, using atomic emission spectrometry (ICP-OES). The elemental concentrations in decoctions were significantly lower than those measured in raw materials, dropping down to levels of negligible health concern. Differences observed in raw materials were not observed anymore in the corresponding decoctions. Also, the elemental transfer rate from dried lichen to decoction was extremely element-specific, ranging from 2% for Cu to 95% for Zn.
[Mh] Termos MeSH primário: Líquens
Parmeliaceae
Preparações de Plantas/química
Oligoelementos/análise
[Mh] Termos MeSH secundário: Poluentes Atmosféricos/análise
Monitoramento Ambiental/métodos
Seres Humanos
Líquens/química
Parmeliaceae/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Air Pollutants); 0 (Plant Preparations); 0 (Trace Elements)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170509
[St] Status:MEDLINE


  2 / 23 MEDLINE  
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[PMID]:28296214
[Au] Autor:Matteucci E; Occhipinti A; Piervittori R; Maffei ME; Favero-Longo SE
[Ad] Endereço:Unità di Lichenologia, Dipartimento di Scienze della Vita e Biologia dei Sistemi, Università degli Studi di Torino, Viale Mattioli 25, 10125, Torino, Italia.
[Ti] Título:Morphological, Secondary Metabolite and ITS (rDNA) Variability within Usnic Acid-Containing Lichen Thalli of Xanthoparmelia Explored at the Local Scale of Rock Outcrop in W-Alps.
[So] Source:Chem Biodivers;14(6), 2017 Jun.
[Is] ISSN:1612-1880
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Lichen secondary metabolites (LSMs) are regarded with interest for valuable biological properties, but chemical variability among/within lichen taxa has been only fragmentarily characterized by advanced analytical techniques. Knowledge of variability at a local geographic scale has been particularly neglected, while it should address the collection of chemically homogeneous materials to test and exploit LSMs. Here we evaluated the chemical variability of 48 Xanthoparmelia specimens from two rock outcrops in Western Italian Alps, representative of nine morphotypes and sixteen rDNA ITS haplotypes. Qualitative and quantitative analyses were performed by HPLC-DAD-ESI-MS and UPLC-HDR-DAD, respectively, and revealed the occurrence of 18 LSMs. Chemical partition allowed distinguishing six chemical groups, only partially overlapping with distinct morphotypes and three divergent haplotype groups, which, overall, accounted for the co-occurrence of different taxa only in part identifiable with species described for Europe. Some morphotypes were variable in presence and concentration of LSMs, and chemical divergences also characterized single ITS haplotypes. Accordingly, the collection of chemically homogeneous materials, even at a local scale, may be not properly addressed by morphological features and ITS barcoding, and should be confirmed by a specimen-level chemical characterization.
[Mh] Termos MeSH primário: DNA Ribossômico/genética
Líquens/metabolismo
Parmeliaceae/química
[Mh] Termos MeSH secundário: Benzofuranos
Cromatografia Líquida de Alta Pressão
Europa (Continente)
Haplótipos
Itália
Líquens/química
Parmeliaceae/classificação
Metabolismo Secundário
Espectrometria de Massas em Tandem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Benzofurans); 0 (DNA, Ribosomal); 0W584PFJ77 (usnic acid)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170822
[Lr] Data última revisão:
170822
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170316
[St] Status:MEDLINE
[do] DOI:10.1002/cbdv.201600483


  3 / 23 MEDLINE  
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[PMID]:28041784
[Au] Autor:Fernández-Moriano C; Divakar PK; Crespo A; Gómez-Serranillos MP
[Ad] Endereço:Department of Pharmacology, Faculty of Pharmacy, University Complutense of Madrid, Plaza Ramón y Cajal s/n, 28040 Madrid, Spain.
[Ti] Título:In vitro neuroprotective potential of lichen metabolite fumarprotocetraric acid via intracellular redox modulation.
[So] Source:Toxicol Appl Pharmacol;316:83-94, 2017 Feb 01.
[Is] ISSN:1096-0333
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The lichen-forming fungi Cetraria islandica has been largely used in folk medicines, and it has recently showed promising in vitro antioxidant effects in glial-like cells. Current work aimed at investigating the neuroprotective potential of its major isolated secondary metabolite: the depsidone fumarprotocetraric acid (FUM). H O was used herein to induce oxidative stress (OS)-mediated cytotoxicity in two models of neurons and astrocytes cells (SH-SY5Y and U373-MG cell lines). We found that a pre-treatment with FUM significantly enhanced cell viability compared to H O -treated cells, and we selected the optimal concentrations in each model (1 and 25µg/ml, respectively) for assessing its cytoprotective mechanisms. FUM, which exerted effective peroxyl radical scavenging effect in the chemical oxygen radical antioxidant capacity (ORAC) assay, alleviated the alterations in OS markers provoked by H O . It attenuated intracellular ROS formation, lipid peroxidation and GSH depletion. At mitochondrial level, FUM prevented from the dissipation of mitochondrial membrane potential and the increase in mitochondrial calcium, implying a protective role against oxidative damage in mitochondrial membrane. Similarly, FUM pre-treatment diminished H O -induced apoptosis, as evidenced by the reduction in caspase-3 activity and expression; inmunoblot analysis also revealed a decrease in Bax and an increase in Bcl-2 proteins levels. Furthermore, FUM up-regulated the expression of the antioxidant enzymes catalase, superoxide dismutase-1, and hemeoxigenase-1. These findings and the activation of Nrf2 binding activity in nuclear extracts suggest a plausible involvement of Nrf2 signaling pathway in the cytoprotection by FUM. In conclusion, FUM emerges as a potential drug candidate in the therapy of OS-related diseases, such as the neurodegenerative disorders.
[Mh] Termos MeSH primário: Fumaratos/farmacologia
Líquido Intracelular/efeitos dos fármacos
Líquido Intracelular/metabolismo
Fármacos Neuroprotetores/farmacologia
Parmeliaceae
[Mh] Termos MeSH secundário: Linhagem Celular Tumoral
Sobrevivência Celular/efeitos dos fármacos
Sobrevivência Celular/fisiologia
Relação Dose-Resposta a Droga
Fumaratos/isolamento & purificação
Fumaratos/metabolismo
Seres Humanos
Peróxido de Hidrogênio/toxicidade
Líquens
Fármacos Neuroprotetores/isolamento & purificação
Fármacos Neuroprotetores/metabolismo
Oxirredução
Estresse Oxidativo/efeitos dos fármacos
Estresse Oxidativo/fisiologia
Espécies Reativas de Oxigênio/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fumarates); 0 (Neuroprotective Agents); 0 (Reactive Oxygen Species); 489-50-9 (fumarprotocetraric acid); BBX060AN9V (Hydrogen Peroxide)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170531
[Lr] Data última revisão:
170531
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170103
[St] Status:MEDLINE


  4 / 23 MEDLINE  
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[PMID]:27988167
[Au] Autor:Oukarroum A; El Gharous M; Strasser RJ
[Ad] Endereço:Mohammed VI Polytechnic University, School of Agriculture, Fertilizing and Environment, Ben Guerir, Morocco; Bioenergetics and Microbiology Laboratory, University of Geneva, CH-1254 Jussy-Geneva, Switzerland. Electronic address: oukarroum.abdallah@uqam.ca.
[Ti] Título:Does Parmelina tiliacea lichen photosystem II survive at liquid nitrogen temperatures?
[So] Source:Cryobiology;74:160-162, 2017 Feb.
[Is] ISSN:1090-2392
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Parmelina tiliacea lichens kept in the wet and dry state were stored in liquid nitrogen for 1 week and the subsequent recovery of their photosynthetic apparatus was followed. The chlorophyll a fluorescence rise and the maximum quantum yield of primary photochemistry φ (F /F ) were analysed for this purpose. Storage of wet thalli for 1 week in liquid nitrogen led to an impairment of photosystem II and probably the photosynthetic apparatus as a whole, from which the thalli did not recover over time. Thalli exposed in the dry state thalli were far less affected by the treatment and recovered well. These results indicate that the thalli are extremely tolerant to liquid nitrogen temperatures only in the dry state.
[Mh] Termos MeSH primário: Clorofila/química
Parmeliaceae/metabolismo
Fotossíntese/fisiologia
Complexo de Proteína do Fotossistema II/metabolismo
[Mh] Termos MeSH secundário: Temperatura Baixa
Nitrogênio
Parmeliaceae/enzimologia
Fotoquímica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Photosystem II Protein Complex); 1406-65-1 (Chlorophyll); N762921K75 (Nitrogen); YF5Q9EJC8Y (chlorophyll a)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170907
[Lr] Data última revisão:
170907
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161219
[St] Status:MEDLINE


  5 / 23 MEDLINE  
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[PMID]:27828951
[Au] Autor:Wei X; McCune B; Lumbsch HT; Li H; Leavitt S; Yamamoto Y; Tchabanenko S; Wei J
[Ad] Endereço:State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
[Ti] Título:Limitations of Species Delimitation Based on Phylogenetic Analyses: A Case Study in the Hypogymnia hypotrypa Group (Parmeliaceae, Ascomycota).
[So] Source:PLoS One;11(11):e0163664, 2016.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Delimiting species boundaries among closely related lineages often requires a range of independent data sets and analytical approaches. Similar to other organismal groups, robust species circumscriptions in fungi are increasingly investigated within an empirical framework. Here we attempt to delimit species boundaries in a closely related clade of lichen-forming fungi endemic to Asia, the Hypogymnia hypotrypa group (Parmeliaceae). In the current classification, the Hypogymnia hypotrypa group includes two species: H. hypotrypa and H. flavida, which are separated based on distinctive reproductive modes, the former producing soredia but absent in the latter. We reexamined the relationship between these two species using phenotypic characters and molecular sequence data (ITS, GPD, and MCM7 sequences) to address species boundaries in this group. In addition to morphological investigations, we used Bayesian clustering to identify potential genetic groups in the H. hypotrypa/H. flavida clade. We also used a variety of empirical, sequence-based species delimitation approaches, including: the "Automatic Barcode Gap Discovery" (ABGD), the Poisson tree process model (PTP), the General Mixed Yule Coalescent (GMYC), and the multispecies coalescent approach BPP. Different species delimitation scenarios were compared using Bayes factors delimitation analysis, in addition to comparisons of pairwise genetic distances, pairwise fixation indices (FST). The majority of the species delimitation analyses implemented in this study failed to support H. hypotrypa and H. flavida as distinct lineages, as did the Bayesian clustering analysis. However, strong support for the evolutionary independence of H. hypotrypa and H. flavida was inferred using BPP and further supported by Bayes factor delimitation. In spite of rigorous morphological comparisons and a wide range of sequence-based approaches to delimit species, species boundaries in the H. hypotrypa group remain uncertain. This study reveals the potential limitations of relying on distinct reproductive strategies as diagnostic taxonomic characters for Hypogymnia and also the challenges of using popular sequence-based species delimitation methods in groups with recent diversification histories.
[Mh] Termos MeSH primário: DNA Fúngico/genética
Parmeliaceae/genética
Filogenia
Análise de Sequência de DNA/métodos
[Mh] Termos MeSH secundário: Altitude
Teorema de Bayes
Núcleo Celular/genética
China
Análise por Conglomerados
DNA Fúngico/química
DNA Espaçador Ribossômico/genética
Proteínas Fúngicas/genética
Geografia
Japão
Componente 7 do Complexo de Manutenção de Minicromossomo
Parmeliaceae/classificação
Fenótipo
Polimorfismo Genético
Federação Russa
Especificidade da Espécie
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Fungal); 0 (DNA, Ribosomal Spacer); 0 (Fungal Proteins); EC 3.6.4.12 (Minichromosome Maintenance Complex Component 7)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170703
[Lr] Data última revisão:
170703
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161110
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0163664


  6 / 23 MEDLINE  
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[PMID]:27463653
[Au] Autor:Pennisi E
[Ti] Título:SYMBIOSIS. A lichen ménage à trois.
[So] Source:Science;353(6297):337, 2016 Jul 22.
[Is] ISSN:1095-9203
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Parmeliaceae/química
Parmeliaceae/genética
Simbiose
[Mh] Termos MeSH secundário: Basidiomycota/genética
Corantes Fluorescentes
Furanos/análise
Furanos/química
Genômica/métodos
Fenilacetatos/análise
Fenilacetatos/química
Coloração e Rotulagem/métodos
Toxinas Biológicas/análise
Toxinas Biológicas/química
[Pt] Tipo de publicação:NEWS
[Nm] Nome de substância:
0 (Fluorescent Dyes); 0 (Furans); 0 (Phenylacetates); 0 (Toxins, Biological); 13N7RF6M84 (vulpinic acid)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160728
[St] Status:MEDLINE
[do] DOI:10.1126/science.353.6297.337


  7 / 23 MEDLINE  
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[PMID]:27049956
[Au] Autor:Studzinska-Sroka E; Piotrowska H; Kucinska M; Murias M; Bylka W
[Ad] Endereço:a Department of Pharmacognosy , Poznan University of Medical Sciences , Poznan , Poland.
[Ti] Título:Cytotoxic activity of physodic acid and acetone extract from Hypogymnia physodes against breast cancer cell lines.
[So] Source:Pharm Biol;54(11):2480-2485, 2016 Nov.
[Is] ISSN:1744-5116
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:CONTEXT: Lichens produce specific secondary metabolites with different biological activity. OBJECTIVE: This study investigated the cytotoxic effects of physodic acid, in addition to the total phenolic content and cytotoxic and antioxidant activity of acetone extract from Hypogymnia physodes (L.) Nyl. (Parmeliaceae). MATERIALS AND METHODS: Cytotoxicity of physodic acid (0.1-100 µM) was assessed in MDA-MB-231, MCF-7 and T-47D breast cancer cell lines and a nontumorigenic MCF-10A cell line using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, neutral red uptake and crystal violet assays during 72 h of incubation. An MTT assay was also used to assess the cytotoxic effects of the acetone extract (0.1-100 µg/mL) in the MDA-MB-231, MCF-7, T-47D breast cancer cell lines after 72 h. The total phenolic content of the acetone extract, expressed as the gallic acid equivalent, was investigated using Folin-Ciocalteu reagent. The antioxidant activity of the extract was assessed by 2,2-diphenyl-1-picrylhydrazyl and ferric-reducing antioxidant power assays. RESULTS: The cytotoxic activity of physodic acid appeared to be strong in the tumorigenic cell lines (IC 46.0-93.9 µM). The compound was inactive against the nontumorigenic MCF-10A cell line (IC >100 µM). The acetone extract showed cytotoxicity in the breast cancer cell lines (IC 46.2-110.4 µg/mL). The acetone extract was characterized by a high content of polyphenols, and it had significant antioxidant activity. DISCUSSION AND CONCLUSION: Physodic acid and acetone extract from H. physodes displayed cytotoxic effects in the breast cancer cell lines. Furthermore, acetone extract from H. physodes possessed significant antioxidant properties.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/farmacologia
Neoplasias da Mama/tratamento farmacológico
Dibenzoxepinas/farmacologia
Parmeliaceae
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Antioxidantes/farmacologia
Neoplasias da Mama/patologia
Linhagem Celular Tumoral
Feminino
Seres Humanos
Parmeliaceae/química
Fenóis/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Antioxidants); 0 (Dibenzoxepins); 0 (Phenols); 0 (Plant Extracts); X901BNT6BF (physodic acid)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170303
[Lr] Data última revisão:
170303
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160407
[St] Status:MEDLINE


  8 / 23 MEDLINE  
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[PMID]:26979232
[Ti] Título:[Combination with Iceland moss shows effectiveness in a study].
[Ti] Título:Kombination mit Isländisch Moos zeigt Effektivität in Studie..
[So] Source:MMW Fortschr Med;158(5):73, 2016 Mar 17.
[Is] ISSN:1438-3276
[Cp] País de publicação:Germany
[La] Idioma:ger
[Mh] Termos MeSH primário: Resfriado Comum/tratamento farmacológico
Ácido Hialurônico/uso terapêutico
Parmeliaceae
Faringite/tratamento farmacológico
Fitoterapia
Extratos Vegetais/uso terapêutico
[Mh] Termos MeSH secundário: Combinação de Medicamentos
Seres Humanos
[Pt] Tipo de publicação:NEWS
[Nm] Nome de substância:
0 (Drug Combinations); 0 (Plant Extracts); 9004-61-9 (Hyaluronic Acid)
[Em] Mês de entrada:1606
[Cu] Atualização por classe:160316
[Lr] Data última revisão:
160316
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160317
[St] Status:MEDLINE
[do] DOI:10.1007/s15006-016-7955-0


  9 / 23 MEDLINE  
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[PMID]:26961526
[Au] Autor:Puy-Alquiza MJ; Reyes V; Wrobel K; Wrobel K; Torres Elguera JC; Miranda-Aviles R
[Ad] Endereço:Department of Mining, Metallurgy and Geology, Division of Engineering, University of Guanajuato, L. de Retana 5, 36000, Guanajuato, Mexico. yosune@ugto.mx.
[Ti] Título:Polycyclic aromatic hydrocarbons in urban tunnels of Guanajuato city (Mexico) measured in deposited dust particles and in transplanted lichen Xanthoparmelia mexicana (Gyeln.) Hale.
[So] Source:Environ Sci Pollut Res Int;23(12):11947-56, 2016 Jun.
[Is] ISSN:1614-7499
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Sixteen priority PAHs were determined in five urban tunnels of Guanajuato city, through which about 4 % of population walks and about 25,000 vehicles pass daily. Xanthoparmelia mexicana (Gyeln.) Hale, highly abundant lichen in this region, was exposed during 6 months and then the samples were collected together with the wall dust; both materials were analyzed by gas chromatography-mass spectrometry. Total PAH concentrations in dust and in lichen samples were in the range 1392-7961 ng g(-1) (average per tunnel 4637 ng g(-1)) and 522-3571 ng g(-1) (average 2587 ng g(-1)), respectively. In dust, the highest concentrations corresponded to PYR, FLA, BaA, CHR, BaP, and PHE, whereas in lichens the most abundant were DahA, IcdP, BghiP, and PYR. The obtained results suggested passive deposition of PAHs on lipophilic lichen surface rather than phenomena associated with metabolic activity of the exposed organisms. Application of seven different molecular diagnostic ratios pointed to gasoline-operated cars as the principal source of PAHs. Based on the obtained results and their comparison with data reported for other geographical regions, Guanajuato tunnels were considered moderately contaminated with PAHs; however toxic BaP equivalent concentrations integrated for seven carcinogenic compounds presented relatively high values in four tunnels: 567-1051 ngBaPeq g(-1) as evaluated for dust samples. Since up to 7000 persons walk daily through tunnels, the obtained data call for more detailed study evaluating PAHs toxicity in Guanajuato population.
[Mh] Termos MeSH primário: Cidades/estatística & dados numéricos
Poeira/análise
Monitoramento Ambiental/métodos
Parmeliaceae/química
Hidrocarbonetos Aromáticos Policíclicos/análise
[Mh] Termos MeSH secundário: Carcinógenos/análise
Cromatografia Gasosa-Espectrometria de Massas
Seres Humanos
Líquens
México
Hidrocarbonetos Aromáticos Policíclicos/toxicidade
Emissões de Veículos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Carcinogens); 0 (Dust); 0 (Polycyclic Aromatic Hydrocarbons); 0 (Vehicle Emissions)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160311
[St] Status:MEDLINE
[do] DOI:10.1007/s11356-016-6256-6


  10 / 23 MEDLINE  
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[PMID]:26948420
[Au] Autor:Pongpairoj K; Puangpet P; Thaiwat S; McFadden JP
[Ad] Endereço:Department of Cutaneous Allergy, St John's Institute of Dermatology, St Thomas' Hospital, London SE1 9RT, UK.
[Ti] Título:Should Evernia furfuracea be included in a baseline screening series of contact allergens?
[So] Source:Contact Dermatitis;74(4):257-8, 2016 Apr.
[Is] ISSN:1600-0536
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Dermatite Alérgica de Contato/etiologia
Parmeliaceae
Perfumes/efeitos adversos
Extratos Vegetais/efeitos adversos
[Mh] Termos MeSH secundário: Cosméticos/química
Dermatite Alérgica de Contato/diagnóstico
Produtos Domésticos
Seres Humanos
Testes do Emplastro/métodos
[Pt] Tipo de publicação:LETTER
[Nm] Nome de substância:
0 (Cosmetics); 0 (Perfume); 0 (Plant Extracts)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160308
[St] Status:MEDLINE
[do] DOI:10.1111/cod.12510



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