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[PMID]:28449241
[Au] Autor:Knuppertz L; Osiewacz HD
[Ad] Endereço:Institute of Molecular Biosciences and Cluster of Excellence 'Macromolecular Complexes', Department of Biosciences, J. W. Goethe University, Frankfurt, Germany.
[Ti] Título:Autophagy compensates impaired energy metabolism in CLPXP-deficient Podospora anserina strains and extends healthspan.
[So] Source:Aging Cell;16(4):704-715, 2017 Aug.
[Is] ISSN:1474-9726
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The degradation of nonfunctional mitochondrial proteins is of fundamental relevance for maintenance of cellular homeostasis. The heteromeric CLPXP protein complex in the mitochondrial matrix is part of this process. In the fungal aging model Podospora anserina, ablation of CLPXP leads to an increase in healthy lifespan. Here, we report that this counterintuitive increase depends on a functional autophagy machinery. In PaClpXP mutants, autophagy is involved in energy conservation and the compensation of impairments in respiration. Strikingly, despite the impact on mitochondrial function, it is not mitophagy but general autophagy that is constitutively induced and required for longevity. In contrast, in another long-lived mutant ablated for the mitochondrial PaIAP protease, autophagy is neither induced nor required for lifespan extension. Our data provide novel mechanistic insights into the capacity of different forms of autophagy to compensate impairments of specific components of the complex mitochondrial quality control network and about the biological role of mitochondrial CLPXP in the control of cellular energy metabolism.
[Mh] Termos MeSH primário: Autofagia/genética
Endopeptidase Clp/genética
Proteínas Fúngicas/genética
Regulação Fúngica da Expressão Gênica
Mitocôndrias/enzimologia
Podospora/genética
[Mh] Termos MeSH secundário: Divisão Celular
Endopeptidase Clp/deficiência
Metabolismo Energético/genética
Proteínas Fúngicas/metabolismo
Viabilidade Microbiana
Mitocôndrias/genética
Mutação
Podospora/enzimologia
Podospora/crescimento & desenvolvimento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fungal Proteins); EC 3.4.21.92 (Endopeptidase Clp)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171201
[Lr] Data última revisão:
171201
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170428
[St] Status:MEDLINE
[do] DOI:10.1111/acel.12600


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[PMID]:28629791
[Au] Autor:Xie N; Ruprich-Robert G; Chapeland-Leclerc F; Coppin E; Lalucque H; Brun S; Debuchy R; Silar P
[Ad] Endereço:Shenzhen Key Laboratory of Microbial Genetic Engineering, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518060, China; Univ Paris Diderot, Sorbonne Paris Cité, Laboratoire Interdisciplinaire des Energies de Demain, 75205 Paris Cedex 13, France.
[Ti] Título:Inositol-phosphate signaling as mediator for growth and sexual reproduction in Podospora anserina.
[So] Source:Dev Biol;429(1):285-305, 2017 09 01.
[Is] ISSN:1095-564X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The molecular pathways involved in the development of multicellular fruiting bodies in fungi are still not well known. Especially, the interplay between the mycelium, the female tissues and the zygotic tissues of the fruiting bodies is poorly documented. Here, we describe PM154, a new strain of the model ascomycetes Podospora anserina able to mate with itself and that enabled the easy recovery of new mutants affected in fruiting body development. By complete genome sequencing of spod1, one of the new mutants, we identified an inositol phosphate polykinase gene as essential, especially for fruiting body development. A factor present in the wild type and diffusible in mutant hyphae was able to induce the development of the maternal tissues of the fruiting body in spod1, but failed to promote complete development of the zygotic ones. Addition of myo-inositol in the growth medium was able to increase the number of developing fruiting bodies in the wild type, but not in spod1. Overall, the data indicated that inositol and inositol polyphosphates were involved in promoting fruiting body maturation, but also in regulating the number of fruiting bodies that developed after fertilization. The same effect of inositol was seen in two other fungi, Sordaria macrospora and Chaetomium globosum. Key role of the inositol polyphosphate pathway during fruiting body maturation appears thus conserved during the evolution of Sordariales fungi.
[Mh] Termos MeSH primário: Fosfatos de Inositol/metabolismo
Podospora/crescimento & desenvolvimento
Podospora/metabolismo
Transdução de Sinais
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Núcleo Celular/metabolismo
Fertilidade
Carpóforos/metabolismo
Proteínas Fúngicas/química
Proteínas Fúngicas/metabolismo
Genes Fúngicos
Proteínas de Fluorescência Verde/metabolismo
Inositol/metabolismo
Sistema de Sinalização das MAP Quinases
Mosaicismo
Mutação/genética
Fenótipo
Pigmentos Biológicos/metabolismo
Podospora/enzimologia
Podospora/genética
Transporte Proteico
Reprodução
Sordariales/metabolismo
Esporos Fúngicos/metabolismo
Temperatura Ambiente
Zigoto/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Fungal Proteins); 0 (Inositol Phosphates); 0 (Pigments, Biological); 0 (enhanced green fluorescent protein); 147336-22-9 (Green Fluorescent Proteins); 4L6452S749 (Inositol)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171111
[Lr] Data última revisão:
171111
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170621
[St] Status:MEDLINE


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[PMID]:28406433
[Au] Autor:Loquet A; Saupe SJ
[Ad] Endereço:Institute of Chemistry and Biology of Membranes and Nanoobjects, UMR 5248 CBMN-CNRS Université de Bordeaux, Allée Geoffroy Saint-Hillaire, 33600 Pessac, France. a.loquet@iecb.u-bordeaux.fr.
[Ti] Título:Diversity of Amyloid Motifs in NLR Signaling in Fungi.
[So] Source:Biomolecules;7(2), 2017 Apr 13.
[Is] ISSN:2218-273X
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Amyloid folds not only represent the underlying cause of a large class of human diseases but also display a variety of functional roles both in prokaryote and eukaryote organisms. Among these roles is a recently-described activity in signal transduction cascades functioning in host defense and programmed cell death and involving Nod-like receptors (NLRs). In different fungal species, prion amyloid folds convey activation signals from a receptor protein to an effector domain by an amyloid templating and propagation mechanism. The discovery of these amyloid signaling motifs derives from the study of [Het-s], a fungal prion of the species . These signaling pathways are typically composed of two basic components encoded by adjacent genes, the NLR receptor bearing an amyloid motif at the N-terminal end and a cell death execution protein with a HeLo pore-forming domain bearing a C-terminal amyloid motif. Activation of the NLR receptor allows for amyloid folding of the N-terminal amyloid motifs which then template trans-conformation of the homologous motif in the cell death execution protein. A variety of such motifs, which differ by their sequence signature, have been described in fungi. Among them, the PP-motif bears resemblance with the RHIM amyloid motif involved in the necroptosis pathway in mammals suggesting an evolutionary conservation of amyloid signaling from fungi to mammals.
[Mh] Termos MeSH primário: Amiloide/metabolismo
Proteínas NLR/metabolismo
Podospora/metabolismo
[Mh] Termos MeSH secundário: Animais
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Amyloid); 0 (NLR Proteins)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170714
[Lr] Data última revisão:
170714
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170414
[St] Status:MEDLINE


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[PMID]:28347269
[Au] Autor:Philipp O; Hamann A; Osiewacz HD; Koch I
[Ad] Endereço:Molecular Bioinformatics, Institute of Computer Science, Faculty of Computer Science and Mathematics and Cluster of Excellence 'Macromolecular Complexes', Johann Wolfgang Goethe-University Frankfurt am Main, Robert-Mayer-Str. 11-15, Frankfurt am Main, 60325, Germany.
[Ti] Título:The autophagy interaction network of the aging model Podospora anserina.
[So] Source:BMC Bioinformatics;18(1):196, 2017 Mar 27.
[Is] ISSN:1471-2105
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Autophagy is a conserved molecular pathway involved in the degradation and recycling of cellular components. It is active either as response to starvation or molecular damage. Evidence is emerging that autophagy plays a key role in the degradation of damaged cellular components and thereby affects aging and lifespan control. In earlier studies, it was found that autophagy in the aging model Podospora anserina acts as a longevity assurance mechanism. However, only little is known about the individual components controlling autophagy in this aging model. Here, we report a biochemical and bioinformatics study to detect the protein-protein interaction (PPI) network of P. anserina combining experimental and theoretical methods. RESULTS: We constructed the PPI network of autophagy in P. anserina based on the corresponding networks of yeast and human. We integrated PaATG8 interaction partners identified in an own yeast two-hybrid analysis using ATG8 of P. anserina as bait. Additionally, we included age-dependent transcriptome data. The resulting network consists of 89 proteins involved in 186 interactions. We applied bioinformatics approaches to analyze the network topology and to prove that the network is not random, but exhibits biologically meaningful properties. We identified hub proteins which play an essential role in the network as well as seven putative sub-pathways, and interactions which are likely to be evolutionary conserved amongst species. We confirmed that autophagy-associated genes are significantly often up-regulated and co-expressed during aging of P. anserina. CONCLUSIONS: With the present study, we provide a comprehensive biological network of the autophagy pathway in P. anserina comprising PPI and gene expression data. It is based on computational prediction as well as experimental data. We identified sub-pathways, important hub proteins, and evolutionary conserved interactions. The network clearly illustrates the relation of autophagy to aging processes and enables further specific studies to understand autophagy and aging in P. anserina as well as in other systems.
[Mh] Termos MeSH primário: Envelhecimento/genética
Autofagia/genética
Podospora/genética
[Mh] Termos MeSH secundário: Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170828
[Lr] Data última revisão:
170828
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170329
[St] Status:MEDLINE
[do] DOI:10.1186/s12859-017-1603-2


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[PMID]:28188936
[Au] Autor:Mäkelä MR; Bouzid O; Robl D; Post H; Peng M; Heck A; Altelaar M; de Vries RP
[Ad] Endereço:Fungal Physiology, Westerdijk Fungal Biodiversity Institute & Fungal Molecular Physiology, Utrecht University, Uppsalalaan 8, 3584 CT, Utrecht, The Netherlands; Department of Food and Environmental Sciences, Division of Microbiology and Biotechnology, P.O. Box 56, Viikinkaari 9, University of He
[Ti] Título:Cultivation of Podospora anserina on soybean hulls results in an efficient enzyme cocktail for plant biomass hydrolysis.
[So] Source:N Biotechnol;37(Pt B):162-171, 2017 Jul 25.
[Is] ISSN:1876-4347
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The coprophilic ascomycete fungus Podospora anserina was cultivated on three different plant biomasses, i.e. cotton seed hulls (CSH), soybean hulls (SBH) and acid-pretreated wheat straw (WS) for four days, and the potential of the produced enzyme mixtures was compared in the enzymatic saccharification of the corresponding lignocellulose feedstocks. The enzyme cocktail P. anserina produced after three days of growth on SBH showed superior capacity to release reducing sugars from all tested plant biomass feedstocks compared to the enzyme mixtures from CSH and WS cultures. Detailed proteomics analysis of the culture supernatants revealed that SBH contained the most diverse set of enzymes targeted on plant cell wall polymers and was particularly abundant in xylan, mannan and pectin acting enzymes. The importance of lytic polysaccharide monooxygenases (LPMOs) in plant biomass deconstruction was supported by identification of 20 out of 33 AA9 LPMOs in the SBH cultures. The results highlight the suitability of P. anserina as a source of plant cell wall degrading enzymes for biotechnological applications and the importance of selecting the most optimal substrate for the production of enzyme mixtures.
[Mh] Termos MeSH primário: Biomassa
Podospora/enzimologia
Podospora/crescimento & desenvolvimento
Feijão de Soja/metabolismo
[Mh] Termos MeSH secundário: Biotecnologia
Gossypium/anatomia & histologia
Gossypium/metabolismo
Hidrólise
Lignina/metabolismo
Caules de Planta/metabolismo
Podospora/metabolismo
Feijão de Soja/anatomia & histologia
Triticum/anatomia & histologia
Triticum/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
11132-73-3 (lignocellulose); 9005-53-2 (Lignin)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170426
[Lr] Data última revisão:
170426
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170212
[St] Status:MEDLINE


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[PMID]:27979655
[Au] Autor:Lalucque H; Malagnac F; Green K; Gautier V; Grognet P; Chan Ho Tong L; Scott B; Silar P
[Ad] Endereço:Univ. Paris Diderot, Sorbonne Paris Cité, Laboratoire Interdisciplinaire des Energies de Demain (LIED), 75205 Paris, France.
[Ti] Título:IDC2 and IDC3, two genes involved in cell non-autonomous signaling of fruiting body development in the model fungus Podospora anserina.
[So] Source:Dev Biol;421(2):126-138, 2017 Jan 15.
[Is] ISSN:1095-564X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Filamentous ascomycetes produce complex multicellular structures during sexual reproduction. Little is known about the genetic pathways enabling the construction of such structures. Here, with a combination of classical and reverse genetic methods, as well as genetic mosaic and graft analyses, we identify and provide evidence for key roles for two genes during the formation of perithecia, the sexual fruiting bodies, of the filamentous fungus Podospora anserina. Data indicate that the proteins coded by these two genes function cell-non-autonomously and that their activity depends upon conserved cysteines, making them good candidate for being involved in the transmission of a reactive oxygen species (ROS) signal generated by the PaNox1 NADPH oxidase inside the maturing fruiting body towards the PaMpk1 MAP kinase, which is located inside the underlying mycelium, in which nutrients are stored. These data provide important new insights to our understanding of how fungi build multicellular structures.
[Mh] Termos MeSH primário: Carpóforos/crescimento & desenvolvimento
Carpóforos/genética
Proteínas Fúngicas/genética
Genes Fúngicos
Podospora/crescimento & desenvolvimento
Podospora/genética
Transdução de Sinais/genética
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Western Blotting
Celulose/farmacologia
Sequência Conservada
Cisteína/metabolismo
Evolução Molecular
Proteínas Fúngicas/química
Proteínas Fúngicas/metabolismo
Deleção de Genes
Teste de Complementação Genética
Proteínas de Fluorescência Verde/metabolismo
Mosaicismo
Micélio/metabolismo
Fenótipo
Fosforilação/efeitos dos fármacos
Frações Subcelulares/metabolismo
Vacúolos/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fungal Proteins); 147336-22-9 (Green Fluorescent Proteins); 9004-34-6 (Cellulose); K848JZ4886 (Cysteine)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170606
[Lr] Data última revisão:
170606
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161217
[St] Status:MEDLINE


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[PMID]:27648755
[Au] Autor:Daskalov A
[Ad] Endereço:a Department of Plant and Microbial Biology , University of California , Berkeley , CA , USA .
[Ti] Título:On the evolutionary trajectories of signal-transducing amyloids in fungi and beyond.
[So] Source:Prion;10(5):362-368, 2016 Sep 02.
[Is] ISSN:1933-690X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In the last decade, multiple reports have established that amyloids can bear important functional roles in a variety of biological processes and in distant taxonomic clades. In filamentous fungi, amyloids are involved in a signal transducing mechanism in which a group of NOD-like receptors (NLRs) controls downstream effector proteins to induce a programmed cell death reaction. A structurally characterized example of fungal signal-transducing amyloid is the prion-forming domain (PFD) of the HET-S toxin from Podospora anserina. Amyloid-mediated programmed cell death is equally reported in metazoans in the context of innate immunity and antiviral response. The cell death reaction, described as programmed necrosis, is dependent on an amyloid-forming RHIM motif (RIP homotypic interaction motif). An evolutionary link between the RHIM and the PFD signaling amyloids has been previously reported. Our recent study ties further the signaling amyloids in fungi and metazoans, reporting a fungal signal-transducing domain with amyloid and prion-like properties, which shows significant sequence similarity to the metazoan RHIM motif. Here, I discuss the expanding class of the signal-transducing amyloids and reflect on the possible evolutionary scenarios of their diversification.
[Mh] Termos MeSH primário: Amiloide/metabolismo
Evolução Biológica
Podospora/metabolismo
Transdução de Sinais
[Mh] Termos MeSH secundário: Imunidade Inata
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amyloid)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171107
[Lr] Data última revisão:
171107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160921
[St] Status:MEDLINE


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[PMID]:27557418
[Au] Autor:Li Y; Yue Q; Krausert NM; An Z; Gloer JB; Bills GF
[Ad] Endereço:Texas Therapeutic Institute, The Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston , Houston, Texas 77054, United States.
[Ti] Título:Emestrins: Anti-Cryptococcus Epipolythiodioxopiperazines from Podospora australis.
[So] Source:J Nat Prod;79(9):2357-63, 2016 Sep 23.
[Is] ISSN:1520-6025
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Eleven emestrin-type epipolythiodioxopiperazines, including four new compounds, emestrins H-K (1-4), were isolated from the crude extracts of two strains of the coprophilous fungus Podospora australis. The structures of 1-4 were established primarily by analysis of NMR data, and the absolute configuration of C-6 in 1 was independently assigned using the modified Mosher method. Four of the known emestrins obtained (emestrins C-E and MPC1001C) were found to selectively inhibit the growth of Cryptococcus neoformans. These results also represent the first report of chemistry from any strain of P. australis.
[Mh] Termos MeSH primário: Antifúngicos/isolamento & purificação
Antifúngicos/farmacologia
Cryptococcus neoformans/efeitos dos fármacos
Piperazinas/isolamento & purificação
Piperazinas/farmacologia
Podospora/química
[Mh] Termos MeSH secundário: Animais
Antifúngicos/química
Defecação
Cavalos
Testes de Sensibilidade Microbiana
Estrutura Molecular
Ressonância Magnética Nuclear Biomolecular
Piperazinas/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (Piperazines); 97816-62-1 (emestrin)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170627
[Lr] Data última revisão:
170627
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160825
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jnatprod.6b00498


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[PMID]:27442014
[Au] Autor:Sellem CH; di Rago JP; Lasserre JP; Ackerman SH; Sainsard-Chanet A
[Ad] Endereço:Institute for Integrative Biology of the Cell (I2BC), CEA-CNRS-Université Paris-Sud, Gif sur Yvette, France.
[Ti] Título:Regulation of Aerobic Energy Metabolism in Podospora anserina by Two Paralogous Genes Encoding Structurally Different c-Subunits of ATP Synthase.
[So] Source:PLoS Genet;12(7):e1006161, 2016 07.
[Is] ISSN:1553-7404
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Most of the ATP in living cells is produced by an F-type ATP synthase. This enzyme uses the energy of a transmembrane electrochemical proton gradient to synthesize ATP from ADP and inorganic phosphate. Proton movements across the membrane domain (FO) of the ATP synthase drive the rotation of a ring of 8-15 c-subunits, which induces conformational changes in the catalytic part (F1) of the enzyme that ultimately promote ATP synthesis. Two paralogous nuclear genes, called Atp9-5 and Atp9-7, encode structurally different c-subunits in the filamentous fungus Podospora anserina. We have in this study identified differences in the expression pattern for the two genes that correlate with the mitotic activity of cells in vegetative mycelia: Atp9-7 is transcriptionally active in non-proliferating (stationary) cells while Atp9-5 is expressed in the cells at the extremity (apex) of filaments that divide and are responsible for mycelium growth. When active, the Atp9-5 gene sustains a much higher rate of c-subunit synthesis than Atp9-7. We further show that the ATP9-7 and ATP9-5 proteins have antagonist effects on the longevity of P. anserina. Finally, we provide evidence that the ATP9-5 protein sustains a higher rate of mitochondrial ATP synthesis and yield in ATP molecules per electron transferred to oxygen than the c-subunit encoded by Atp9-7. These findings reveal that the c-subunit genes play a key role in the modulation of ATP synthase production and activity along the life cycle of P. anserina. Such a degree of sophistication for regulating aerobic energy metabolism has not been described before.
[Mh] Termos MeSH primário: Metabolismo Energético
Proteínas Fúngicas/genética
ATPases Mitocondriais Próton-Translocadoras/genética
Podospora/genética
[Mh] Termos MeSH secundário: Aerobiose
Inibidores Enzimáticos/farmacologia
Proteínas Fúngicas/antagonistas & inibidores
Proteínas Fúngicas/metabolismo
Expressão Gênica
Regulação Fúngica da Expressão Gênica
ATPases Mitocondriais Próton-Translocadoras/antagonistas & inibidores
ATPases Mitocondriais Próton-Translocadoras/metabolismo
Oligomicinas/farmacologia
Podospora/enzimologia
Subunidades Proteicas/antagonistas & inibidores
Subunidades Proteicas/genética
Subunidades Proteicas/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Enzyme Inhibitors); 0 (Fungal Proteins); 0 (Oligomycins); 0 (Protein Subunits); EC 3.6.3.- (Mitochondrial Proton-Translocating ATPases)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170324
[Lr] Data última revisão:
170324
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160722
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pgen.1006161


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[PMID]:27353975
[Au] Autor:Timpano H; Chan Ho Tong L; Gautier V; Lalucque H; Silar P
[Ad] Endereço:Univ Paris Diderot, Sorbonne Paris Cité, Laboratoire Interdisciplinaire des Energies de Demain, 75205 Paris CEDEX 13, France; Univ Paris Sud 11, Institut de Génétique et Microbiologie, 91405 Orsay cedex, France.
[Ti] Título:The PaPsr1 and PaWhi2 genes are members of the regulatory network that connect stationary phase to mycelium differentiation and reproduction in Podospora anserina.
[So] Source:Fungal Genet Biol;94:1-10, 2016 09.
[Is] ISSN:1096-0937
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In filamentous fungi, entrance into stationary phase is complex as it is accompanied by several differentiation and developmental processes, including the synthesis of pigments, aerial hyphae, anastomoses and sporophores. The regulatory networks that control these processes are still incompletely known. The analysis of the "Impaired in the development of Crippled Growth (IDC)" mutants of the model filamentous ascomycete Podospora anserina has already yielded important information regarding the pathway regulating entrance into stationary phase. Here, the genes affected in two additional IDC mutants are identified as orthologues of the Saccharomyces cerevisiae WHI2 and PSR1 genes, known to regulate stationary phase in this yeast, arguing for a conserved role of these proteins throughout the evolution of ascomycetes.
[Mh] Termos MeSH primário: Regulação Fúngica da Expressão Gênica
Redes Reguladoras de Genes
Micélio/genética
Podospora/genética
[Mh] Termos MeSH secundário: Proteínas Fúngicas/genética
Teste de Complementação Genética
Mutação
Micélio/crescimento & desenvolvimento
Fosforilação
Podospora/crescimento & desenvolvimento
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Fungal Proteins)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171117
[Lr] Data última revisão:
171117
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160630
[St] Status:MEDLINE



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