Base de dados : MEDLINE
Pesquisa : B01.300.107.950 [Categoria DeCS]
Referências encontradas : 507 [refinar]
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[PMID]:28486854
[Au] Autor:Lei CW; Yang ZQ; Zeng YP; Zhou Y; Huang Y; He XS; Li GY; Yuan XH
[Ad] Endereço:a School of Life Science and Engineering , Southwest University of Science and Technology , Mianyang , P.R. China.
[Ti] Título:Xylastriasan A, a new cytochalasan from the fungus Xylaria striata.
[So] Source:Nat Prod Res;32(1):7-13, 2018 Jan.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Xylastriasan A (1), a new cytochalasan alkaloid with a rare 5/6/6/5/6 pentacyclic skeleton, and ergosterol (2) were isolated from the ethanol extract of fruiting bodies of the fungus Xylaria striata. Their structures were determined by analysis of their spectroscopic data. Compound 1 exhibited weak cytotoxic activity against HEPG2, B16 and A549 cell lines with IC values of 93.61, 85.61 and 91.58 µM, respectively. Ergosterol (2) potentiated pentobarbital-induced sleep by not only increasing the number of falling asleep and prolonging sleeping time but also reducing sleep latency at a dosage of 5 mg/kg.
[Mh] Termos MeSH primário: Alcaloides/farmacologia
Citocalasinas/farmacologia
Ergosterol/farmacologia
Hipnóticos e Sedativos/farmacologia
Sono/efeitos dos fármacos
Xylariales/química
[Mh] Termos MeSH secundário: Alcaloides/química
Alcaloides/isolamento & purificação
Animais
Linhagem Celular
Citocalasinas/química
Citocalasinas/isolamento & purificação
Ergosterol/química
Ergosterol/isolamento & purificação
Células Hep G2
Seres Humanos
Hipnóticos e Sedativos/química
Espectroscopia de Ressonância Magnética
Camundongos Endogâmicos ICR
Estrutura Molecular
Pentobarbital/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkaloids); 0 (Cytochalasins); 0 (Hypnotics and Sedatives); I4744080IR (Pentobarbital); Z30RAY509F (Ergosterol)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170511
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2017.1324959


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[PMID]:29337674
[Au] Autor:Zhou JB; Sun YY; Zheng YL; Yu CQ; Lin HQ; Pang JY
[Ad] Endereço:1School of Chemistry Sun Yat-Sen University, Guangzhou 510275, P. R. China.
[Ti] Título:A study on blocking store-operated Ca2+ entry in pulmonary arterial smooth muscle cells with xyloketals from marine fungi.
[So] Source:Acta Pharm;67(4):557-567, 2017 Dec 20.
[Is] ISSN:1846-9558
[Cp] País de publicação:Croatia
[La] Idioma:eng
[Ab] Resumo:In this study, the effect of four xyloketals 1-4 on store-operated calcium entry (SOCE) was investigated in primary distal pulmonary arterial smooth muscle cells (PASMCs) isolated from mice. The results showed that xyloketal A (1), an unusual ketal with C-3 symmetry, exhibited strong SOCE blocking activity. Secretion of interleukin-8 (IL-8) was also inhibited by xyloketal A. The parallel artificial membrane permeability assay (PAMPA) of 1-4 suggested that these xyloketals penetrated easily through the cell membrane. Moreover, the molecular docking study of xyloketal A with activation region of the stromal interaction molecule (STIM) 1 and the calcium release-activated calcium modulator (ORAI) 1 (STIM1-ORAI1) protein complex, the key domain of SOCE, revealed that xyloketal A exhibited a noncovalent interaction with the key residue lysine 363 (LYS363) in the identified cytosolic regions in STIM1-C. These findings provided useful information about xyloketal A as a SOCE inhibitor for further evaluation.
[Mh] Termos MeSH primário: Canais de Cálcio Ativados pela Liberação de Cálcio/antagonistas & inibidores
Músculo Liso Vascular/efeitos dos fármacos
Artéria Pulmonar/efeitos dos fármacos
Piranos/farmacologia
Xylariales/química
[Mh] Termos MeSH secundário: Animais
Cálcio/análise
Permeabilidade da Membrana Celular/efeitos dos fármacos
Interleucina-8/análise
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Simulação de Acoplamento Molecular
Músculo Liso Vascular/química
Músculo Liso Vascular/citologia
Artéria Pulmonar/química
Artéria Pulmonar/citologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Calcium Release Activated Calcium Channels); 0 (Interleukin-8); 0 (Pyrans); 0 (xyloketal A); 0 (xyloketal B); SY7Q814VUP (Calcium)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180131
[Lr] Data última revisão:
180131
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180117
[St] Status:MEDLINE


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[PMID]:29220409
[Au] Autor:Mata CP; Luque D; Gómez-Blanco J; Rodríguez JM; González JM; Suzuki N; Ghabrial SA; Carrascosa JL; Trus BL; Castón JR
[Ad] Endereço:Department of Structure of Macromolecules, Centro Nacional de Biotecnología (CNB-CSIC), Campus Cantoblanco, Madrid, Spain.
[Ti] Título:Acquisition of functions on the outer capsid surface during evolution of double-stranded RNA fungal viruses.
[So] Source:PLoS Pathog;13(12):e1006755, 2017 Dec.
[Is] ISSN:1553-7374
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Unlike their counterparts in bacterial and higher eukaryotic hosts, most fungal viruses are transmitted intracellularly and lack an extracellular phase. Here we determined the cryo-EM structure at 3.7 Å resolution of Rosellinia necatrix quadrivirus 1 (RnQV1), a fungal double-stranded (ds)RNA virus. RnQV1, the type species of the family Quadriviridae, has a multipartite genome consisting of four monocistronic segments. Whereas most dsRNA virus capsids are based on dimers of a single protein, the ~450-Å-diameter, T = 1 RnQV1 capsid is built of P2 and P4 protein heterodimers, each with more than 1000 residues. Despite a lack of sequence similarity between the two proteins, they have a similar α-helical domain, the structural signature shared with the lineage of the dsRNA bluetongue virus-like viruses. Domain insertions in P2 and P4 preferential sites provide additional functions at the capsid outer surface, probably related to enzyme activity. The P2 insertion has a fold similar to that of gelsolin and profilin, two actin-binding proteins with a function in cytoskeleton metabolism, whereas the P4 insertion suggests protease activity involved in cleavage of the P2 383-residue C-terminal region, absent in the mature viral particle. Our results indicate that the intimate virus-fungus partnership has altered the capsid genome-protective and/or receptor-binding functions. Fungal virus evolution has tended to allocate enzyme activities to the virus capsid outer surface.
[Mh] Termos MeSH primário: Proteínas do Capsídeo/metabolismo
Capsídeo/metabolismo
Modelos Moleculares
Vírus de RNA/metabolismo
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Capsídeo/enzimologia
Capsídeo/ultraestrutura
Proteínas do Capsídeo/química
Proteínas do Capsídeo/genética
Sequência Conservada
Microscopia Crioeletrônica
Evolução Molecular
Imagem Tridimensional
Mutagênese Insercional
Conformação Proteica em alfa-Hélice
Conformação Proteica em Folha beta
Domínios e Motivos de Interação entre Proteínas
Multimerização Proteica
Estabilidade Proteica
Vírus de RNA/enzimologia
Vírus de RNA/genética
Vírus de RNA/ultraestrutura
Alinhamento de Sequência
Homologia Estrutural de Proteína
Propriedades de Superfície
Vírion/enzimologia
Vírion/genética
Vírion/metabolismo
Vírion/ultraestrutura
Xylariales/virologia
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Capsid Proteins)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180109
[Lr] Data última revisão:
180109
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171209
[St] Status:MEDLINE
[do] DOI:10.1371/journal.ppat.1006755


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[PMID]:28463686
[Au] Autor:Li CS; Yang BJ; Turkson J; Cao S
[Ad] Endereço:Department of Pharmaceutical Sciences, Daniel K. Inouye College of Pharmacy, University of Hawai'i at Hilo, 200 West Kawili Street, Hilo, HI 96720, USA; Natural Products and Experimental Therapeutics, University of Hawai'i Cancer Center, 701 Ilalo Street, Honolulu, HI 96813, USA.
[Ti] Título:Anti-proliferative ambuic acid derivatives from Hawaiian endophytic fungus Pestalotiopsis sp. FT172.
[So] Source:Phytochemistry;140:77-82, 2017 Aug.
[Is] ISSN:1873-3700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Five previously undescribed ambuic acid derivatives, pestallic acids A-E and three known analogs were isolated from the cultured broth of Pestalotiopsis sp. FT172. The structures of the pestallic acids A-E were determined through the analysis of HRMS and NMR spectroscopic data. The absolute configurations (ACs) of pestallic acids B-E were assigned by comparison of the experimental electric circular dichroism (ECD) spectra or the optical rotations with those in the literature. All compounds were tested against A2780 and cisplatin resistant A2780 (A2780CisR) cell lines. Pestallic acid E and (+)-ambuic acid showed potent activities with IC values from 3.3 to 17.0 µM.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/química
Cicloexanonas/química
Xylariales/química
[Mh] Termos MeSH secundário: Antineoplásicos Fitogênicos/isolamento & purificação
Linhagem Celular Tumoral
Cicloexanonas/isolamento & purificação
Endófitos/química
Hawaii
Seres Humanos
Estrutura Molecular
Myrsinaceae/microbiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Cyclohexanones); 0 (ambuic acid)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171222
[Lr] Data última revisão:
171222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE


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[PMID]:29183320
[Au] Autor:Subban K; Singh S; Subramani R; Johnpaul M; Chelliah J
[Ad] Endereço:Department of Biochemistry, Indian Institute of Science, Bangalore, Karnataka, 560012, India.
[Ti] Título:Fungal 7-epi-10-deacetyltaxol produced by an endophytic Pestalotiopsis microspora induces apoptosis in human hepatocellular carcinoma cell line (HepG2).
[So] Source:BMC Complement Altern Med;17(1):504, 2017 Nov 28.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Paclitaxel (taxol) is a potent anticancer drug that is used in the treatment of a wide variety of cancerous. In the present study, we identified a taxol derivative named 7-epi-10-deacetyltaxol (EDT) from the culture of an endophytic fungus Pestalotiopsis microspora isolated from the bark of Taxodium mucronatum. This study was carried out to investigate the effects of fungal EDT on cell proliferation, the induction of apoptosis and the molecular mechanisms of apoptosis in human hepatoma HepG2 cells in vitro. METHODS: The endophytic fungus was identified by traditional and molecular taxonomical characterization and the fungal EDT was purified using column chromatography and confirmed by various spectroscopic and chromatographic comparisons with authentic paclitaxel. We studied the in vitro effects of EDT on HepG2 cells for parameters such as cell cycle distribution, DNA fragmentation, reactive oxygen species (ROS) generation and nuclear morphology. Further, western blot analysis was used to evaluate Bcl-2-associated X protein (Bax), B-cell lymphoma 2 (Bcl-2), p38-mitogen activated protein kinase (MAPK) and poly [ADP-ribose] polymerase (PARP) expression. RESULTS: We demonstrate that the fungal EDT exhibited significant in vitro cytotoxicity in HepG2 cells. We investigated cytotoxicity mechanism of EDT in HepG2 cells. The results showed nuclear condensation and DNA fragmentation were observed in cells treated with fungal EDT. Besides, the fungal EDT arrested HepG2 cells at G2/M phase of cell cycle. Furthermore, fungal EDT induced apoptosis in HepG2 cells in a dose-dependent manner associated with ROS generation and increased Bax/Bcl-2 ratio, p38 MAPKs and PARP cleavage. CONCLUSIONS: Our data show that EDT induced apoptotic cell death in HepG2 cells occurs through intrinsic pathway by generation of ROS mediated and activation of MAPK pathway. This is the first report for 7-epi-10-deacetyltaxol (EDT) isolated from a microbial source.
[Mh] Termos MeSH primário: Antineoplásicos/farmacologia
Apoptose/efeitos dos fármacos
Endófitos/química
Taxoides/farmacologia
Xylariales/química
[Mh] Termos MeSH secundário: Antineoplásicos/química
Carcinoma Hepatocelular
Ciclo Celular/efeitos dos fármacos
Sobrevivência Celular/efeitos dos fármacos
Células Hep G2
Seres Humanos
Neoplasias Hepáticas
Espécies Reativas de Oxigênio/metabolismo
Taxoides/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Reactive Oxygen Species); 0 (Taxoids); 78432-77-6 (10-deacetyltaxol)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171219
[Lr] Data última revisão:
171219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171130
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1993-8


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[PMID]:28951605
[Au] Autor:Wang Y; Wang Y; Wu AA; Zhang L; Hu Z; Huang H; Xu Q; Deng X
[Ad] Endereço:State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, China.
[Ti] Título:New 12,8-Eudesmanolides from Eutypella sp. 1-15.
[So] Source:J Antibiot (Tokyo);70(10):1029-1032, 2017 Oct.
[Is] ISSN:0021-8820
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Four new 12,8-Eudesmanolides (1-4) and one known compound 5 named 13-Hydroxy-3,7(11)-eudesmadien-12,8-olide, were isolated from a mangrove rhizosphere-derived fungus Eutypella sp. 1-15. Their structures with absolute stereochemistry were determined by the comprehensive spectroscopic data, experimental and calculated ECD analysis. Compound 1 exhibited potent anticancer activity against JEKO-1 and HepG2 with IC values of 8.4 and 28.5 µM, respectively. Additionally, compound 1 also showed moderate antimicrobial activity.
[Mh] Termos MeSH primário: Antineoplásicos/isolamento & purificação
Antineoplásicos/farmacologia
Sesquiterpenos/isolamento & purificação
Sesquiterpenos/farmacologia
Xylariales/química
[Mh] Termos MeSH secundário: Anti-Infecciosos/química
Anti-Infecciosos/isolamento & purificação
Anti-Infecciosos/farmacologia
Antineoplásicos/química
Linhagem Celular Tumoral
Seres Humanos
Concentração Inibidora 50
Rizosfera
Sesquiterpenos/química
Microbiologia do Solo
Análise Espectral
Xylariales/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Antineoplastic Agents); 0 (Sesquiterpenes); 0 (eudesmanolide)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170928
[St] Status:MEDLINE
[do] DOI:10.1038/ja.2017.89


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[PMID]:28842359
[Au] Autor:Song RY; Wang XB; Yin GP; Liu RH; Kong LY; Yang MH
[Ad] Endereço:State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, People's Republic of China.
[Ti] Título:Isocoumarin derivatives from the endophytic fungus, Pestalotiopsis sp.
[So] Source:Fitoterapia;122:115-118, 2017 Oct.
[Is] ISSN:1873-6971
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Five new isocoumarin derivatives, pestalactone A-C (1-3) and pestapyrone D-E (4-5), together with two known compounds (6-7) were isolated from the solid cultures of the endophytic fungus Pestalotiopsis sp. obtained from Photinia frasery. Their structures were mainly determined by extensive spectroscopic analysis, Mo (OCOCH ) -induced electronic circular dichroism (ECD), and ECD calculation. Compounds 1 and 2 were rare isocoumarin derivatives and derived from distinctive polyketide pathways. Compound 3 exhibited potent antifungal activity against Candida glabrata (ATCC 90030) with an MIC value of 3.49±0.21µg/mL.
[Mh] Termos MeSH primário: Antifúngicos/química
Xylariales/química
[Mh] Termos MeSH secundário: Antifúngicos/isolamento & purificação
Candida glabrata/efeitos dos fármacos
Endófitos/química
Isocumarinas/química
Isocumarinas/isolamento & purificação
Testes de Sensibilidade Microbiana
Estrutura Molecular
Photinia/microbiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (Isocoumarins)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170827
[St] Status:MEDLINE


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[PMID]:28802670
[Au] Autor:Paguigan ND; Al-Huniti MH; Raja HA; Czarnecki A; Burdette JE; González-Medina M; Medina-Franco JL; Polyak SJ; Pearce CJ; Croatt MP; Oberlies NH
[Ad] Endereço:Department of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, NC 27402, USA.
[Ti] Título:Chemoselective fluorination and chemoinformatic analysis of griseofulvin: Natural vs fluorinated fungal metabolites.
[So] Source:Bioorg Med Chem;25(20):5238-5246, 2017 Oct 15.
[Is] ISSN:1464-3391
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Griseofulvin is a fungal metabolite and antifungal drug used for the treatment of dermatophytosis in both humans and animals. Recently, griseofulvin and its analogues have attracted renewed attention due to reports of their potential anticancer effects. In this study griseofulvin (1) and related analogues (2-6, with 4 being new to literature) were isolated from Xylaria cubensis. Six fluorinated analogues (7-12) were synthesized, each in a single step using the isolated natural products and Selectflour, so as to examine the effects of fluorine incorporation on the bioactivities of this structural class. The isolated and synthesized compounds were screened for activity against a panel of cancer cell lines (MDA-MB-435, MDA-MB-231, OVCAR3, and Huh7.5.1) and for antifungal activity against Microsporum gypseum. A comparison of the chemical space occupied by the natural and fluorinated analogues was carried out by using principal component analysis, documenting that the isolated and fluorinated analogues occupy complementary regions of chemical space. However, the most active compounds, including two fluorinated derivatives, were centered around the chemical space that was occupied by the parent compound, griseofulvin, suggesting that modifications must preserve certain attributes of griseofulvin to conserve its activity.
[Mh] Termos MeSH primário: Antifúngicos/farmacologia
Antineoplásicos/farmacologia
Griseofulvina/farmacologia
Informática Médica
Microsporum/efeitos dos fármacos
Xylariales/química
[Mh] Termos MeSH secundário: Antifúngicos/química
Antifúngicos/isolamento & purificação
Antineoplásicos/química
Antineoplásicos/isolamento & purificação
Proliferação Celular/efeitos dos fármacos
Relação Dose-Resposta a Droga
Ensaios de Seleção de Medicamentos Antitumorais
Griseofulvina/química
Griseofulvina/isolamento & purificação
Halogenação
Seres Humanos
Testes de Sensibilidade Microbiana
Estrutura Molecular
Análise de Componente Principal
Relação Estrutura-Atividade
Células Tumorais Cultivadas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (Antineoplastic Agents); 32HRV3E3D5 (Griseofulvin)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171107
[Lr] Data última revisão:
171107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170814
[St] Status:MEDLINE


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[PMID]:28686900
[Au] Autor:Zhao ZZ; Chen HP; Huang Y; Zhang SB; Li ZH; Feng T; Liu JK
[Ad] Endereço:State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China; University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China.
[Ti] Título:Bioactive polyketides and 8,14-seco-ergosterol from fruiting bodies of the ascomycete Daldinia childiae.
[So] Source:Phytochemistry;142:68-75, 2017 Oct.
[Is] ISSN:1873-3700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Seven previously undescribed polyketides, namely childinins A-G, and one previously undescribed 8,14-seco-ergosterol, namely childinasterone A, were obtained from the fruiting bodies of Daldinia childiae. Their structures and absolute configurations were established via extensive spectroscopic analyses, single-crystal X-ray diffraction, and TDDFT/ECD calculations. Childinins A represents the first example of natural product possessing a previously undescribed 6H-naphtho[2,1-c]chromen-6-one scaffold. The single crystal X-ray diffraction of childinasterone A unambiguously determined the absolute configuration of a 8,14-seco-ergosterol skeleton. Childinins A, B, F and G (MIC 54.9 µgâ‹…mL ) showed anti-bacterial activities. Childinasterone A showed significant anti-NO activity (IC 21.2 µM) and weak activities against SMMC-7721, MCF-7 and SW480 cell lines.
[Mh] Termos MeSH primário: Antineoplásicos/isolamento & purificação
Ergosterol/isolamento & purificação
Ergosterol/farmacologia
Carpóforos/química
Policetídeos/isolamento & purificação
Policetídeos/farmacologia
Xylariales/química
[Mh] Termos MeSH secundário: Antineoplásicos/química
Antineoplásicos/farmacologia
Cristalografia por Raios X
Ensaios de Seleção de Medicamentos Antitumorais
Ergosterol/química
Feminino
Seres Humanos
Conformação Molecular
Óxido Nítrico
Ressonância Magnética Nuclear Biomolecular
Policetídeos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Polyketides); 31C4KY9ESH (Nitric Oxide); Z30RAY509F (Ergosterol)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170915
[Lr] Data última revisão:
170915
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170708
[St] Status:MEDLINE


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[PMID]:28675830
[Au] Autor:Lei H; Lin X; Han L; Ma J; Dong K; Wang X; Zhong J; Mu Y; Liu Y; Huang X
[Ad] Endereço:Institute of Microbial Pharmaceuticals, College of Life and Health Sciences, Northeastern University, Shenyang 110819, PR China.
[Ti] Título:Polyketide derivatives from a marine-sponge-associated fungus Pestalotiopsis heterocornis.
[So] Source:Phytochemistry;142:51-59, 2017 Oct.
[Is] ISSN:1873-3700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Twelve previously undescribed polyketide derivatives, heterocornols A-L, and seven known analogues were isolated from a culture of the fungus Pestalotiopsis heterocornis associated with sponge. Their structures were elucidated by a comprehensive spectroscopic data analysis and CD Cotton effects. These compounds were evaluated for cytotoxic and antibacterial activities in vitro. Among them, heterocornols A-C, F-H, methyl-(2-formyl-3-hydroxyphenyl)propanoate, agropyrenol, and vaccinol G exhibited cytotoxicities against four human cancer cell lines with IC values 15-100 µM, and they also showed antibacterial activities against Gram-positive bacteria Staphylococcus aureus and Bacillus subtilis with MIC values ranging from 25 to 100 µg/mL. Moreover, compounds heterocornol C, heterocornol G, agropyrenol, and vaccinol G showed weak antifungal activities against Candida parapsilosis and Cryptococcus neoformans with MIC values 100 µg/mL.
[Mh] Termos MeSH primário: Antibacterianos/isolamento & purificação
Antifúngicos/isolamento & purificação
Policetídeos/isolamento & purificação
Poríferos/microbiologia
Xylariales/química
[Mh] Termos MeSH secundário: Animais
Antibacterianos/química
Antibacterianos/farmacologia
Antifúngicos/química
Antifúngicos/farmacologia
Bacillus subtilis/efeitos dos fármacos
Candida albicans/efeitos dos fármacos
Cryptococcus neoformans/efeitos dos fármacos
Cristalografia por Raios X
Doxorrubicina/farmacologia
Ensaios de Seleção de Medicamentos Antitumorais
Seres Humanos
Masculino
Biologia Marinha
Testes de Sensibilidade Microbiana
Conformação Molecular
Estrutura Molecular
Naftalenos
Ressonância Magnética Nuclear Biomolecular
Policetídeos/química
Policetídeos/farmacologia
Staphylococcus aureus/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Antifungal Agents); 0 (Naphthalenes); 0 (Polyketides); 0 (agropyrenol); 0 (heterocornol C); 0 (heterocornol G); 0 (vaccinol G); 80168379AG (Doxorubicin)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170915
[Lr] Data última revisão:
170915
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170705
[St] Status:MEDLINE



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