Base de dados : MEDLINE
Pesquisa : B01.300.179.120.379 [Categoria DeCS]
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[PMID]:29281878
[Au] Autor:Mustafa IF; Hussein MZ; Saifullah B; Idris AS; Hilmi NHZ; Fakurazi S
[Ad] Endereço:Materials Synthesis and Characterization Laboratory, Institute of Advanced Technology, Universiti Putra Malaysia , 43400 UPM Serdang, Selangor, Malaysia.
[Ti] Título:Synthesis of (Hexaconazole-Zinc/Aluminum-Layered Double Hydroxide Nanocomposite) Fungicide Nanodelivery System for Controlling Ganoderma Disease in Oil Palm.
[So] Source:J Agric Food Chem;66(4):806-813, 2018 Jan 31.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A fungicide, hexaconazole was successfully intercalated into the intergalleries of zinc/aluminum-layered double hydroxide (ZALDH) using the ion-exchange method. Due to the intercalation of hexaconazole, the basal spacing of the ZALDH was increased from 8.7 Å in ZALDH to 29.4 Å in hexaconazole-intercalated ZALDH (HZALDH). The intercalation of hexaconazole into the interlayer of the nanocomposite was confirmed using the Fourier-transform infrared (FTIR) study. This supramolecular chemistry intercalation process enhanced the thermal stability of the hexaconazole moiety. The fungicide loading was estimated to be 51.8%. The nanodelivery system also shows better inhibition toward the Ganoderma boninense growth than the counterpart, free hexaconazole. The results from this work have a great potential to be further explored for combating basal stem rot (BSR) disease in oil palm plantation.
[Mh] Termos MeSH primário: Arecaceae/microbiologia
Fungicidas Industriais/administração & dosagem
Ganoderma/efeitos dos fármacos
Nanocompostos/química
Doenças das Plantas/prevenção & controle
Triazóis/administração & dosagem
[Mh] Termos MeSH secundário: Agroquímicos/administração & dosagem
Alumínio/química
Preparações de Ação Retardada
Hidróxidos/química
Doenças das Plantas/microbiologia
Zinco/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Agrochemicals); 0 (Delayed-Action Preparations); 0 (Fungicides, Industrial); 0 (Hydroxides); 0 (Triazoles); CPD4NFA903 (Aluminum); J41CSQ7QDS (Zinc); SX9R3X1FQV (hexaconazole)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171229
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b04222


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[PMID]:25815561
[Au] Autor:Wang XC; Wu K; Chen H; Shao J; Zhang N; Chen X; Lan J; Liu C
[Ad] Endereço:a Institute of Medicinal Plant Development, Chinese Academy of Medical Science , Beijing , PR China.
[Ti] Título:The complete mitochondrial genome of the white-rot fungus Ganoderma meredithiae (Polyporales, Basidiomycota).
[So] Source:Mitochondrial DNA A DNA Mapp Seq Anal;27(6):4197-4198, 2016 Nov.
[Is] ISSN:2470-1408
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Complete nucleotide sequence of the 78,447 bp mitochondrial genome of the white-rotting fungus Ganoderma meredithiae Adask. & Gilb. has been determined by next-generation sequencing technology. The circular molecule encodes a set of mitochondrial protein and RNA genes, including 15 conserved proteins, 29 tRNAs, large and small ribosomal RNAs, and 18 homing endonucleases, with a GC content of 26.14%. All structural genes are located on the same strand except trnW-CCA. Compared with previously sequenced mtDNAs of G. lucidum and G. sinense, the gene order of protein and rRNA genes among the three mitogenomes is highly conserved; however, the tRNA composition is slightly different. The mitochondrial genome of G. meredithiae will contribute to understanding the phylogeny and evolution of Ganoderma and Ganodermataceae, the group containing many species with high medicinal values.
[Mh] Termos MeSH primário: Ganoderma/genética
Genoma Mitocondrial/genética
[Mh] Termos MeSH secundário: DNA Mitocondrial/genética
Proteínas Fúngicas/genética
Proteínas Mitocondriais/genética
RNA/genética
RNA Fúngico/genética
RNA Ribossômico/genética
RNA de Transferência/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Mitochondrial); 0 (Fungal Proteins); 0 (Mitochondrial Proteins); 0 (RNA, Fungal); 0 (RNA, Ribosomal); 0 (RNA, mitochondrial); 63231-63-0 (RNA); 9014-25-9 (RNA, Transfer)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180118
[Lr] Data última revisão:
180118
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150328
[St] Status:MEDLINE


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[PMID]:29191190
[Au] Autor:Xie L; Zhong X; Liu D; Liu L; Xia Z
[Ad] Endereço:College of Horticulture and Landscape Architecture, Hunan Agricultural University, Changsha, China.
[Ti] Título:The effects of freeze-dried Ganoderma lucidum mycelia on a recurrent oral ulceration rat model.
[So] Source:BMC Complement Altern Med;17(1):511, 2017 Dec 01.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Conventional scientific studies had supported the use of polysaccharides and ß-glucans from a number of fungi, including Ganoderma lucidum for the treatment of recurrent oral ulceration (ROU). Our aim of the present study was to evaluate whether freeze-dried powder from G. lucidum mycelia (FDPGLM) prevents ROU in rats. METHODS: A Sprague-Dawley (SD) rat model with ROU was established by autoantigen injection. The ROU rats were treated with three different dosages of FDPGLM and prednisone acetate (PA), and their effects were evaluated according to the clinical therapeutic evaluation indices of ROU. RESULTS: High-dose FDPGLM induced significantly prolonged total intervals and a reduction in the number of ulcers and ulcer areas, thereby indicating that the treatment was effective in preventing ROU. Enzyme-linked immunosorbent assay (ELISA) showed that high-dose FDPGLM significantly enhanced the serum transforming growth factor-ß1 (TGF-ß1) levels, whereas reduced those of interleukin-6 (IL-6) and interleukin-17 (IL-17). Flow cytometry (FCM) showed that the proportion of CD4 CD25 Foxp3 (forkhead box P3) regulatory T cells (Tregs) significantly increased by 1.5-fold in the high-dose FDPGLM group compared to that in the rat model group (P < 0.01). The application of middle- and high-dose FDPGLM also resulted in the upregulation of Foxp3 and downregulation of retinoid-related orphan receptor gamma t(RORγt) mRNA. CONCLUSION: High-dose FDPGLM possibly plays a role in ROU by promoting CD4 CD25 Foxp3 Treg and inhibiting T helper cell 17 differentiation. This study also shows that FDPGLM may be potentially used as a complementary and alternative medicine treatment scheme for ROU.
[Mh] Termos MeSH primário: Produtos Biológicos/uso terapêutico
Ganoderma/química
Micélio/química
Úlceras Orais/tratamento farmacológico
[Mh] Termos MeSH secundário: Animais
Produtos Biológicos/química
Produtos Biológicos/farmacologia
Citocinas/sangue
Modelos Animais de Doenças
Fatores de Transcrição Forkhead/genética
Fatores de Transcrição Forkhead/metabolismo
Liofilização
Mucosa Bucal/química
Mucosa Bucal/patologia
Prednisona/farmacologia
Prednisona/uso terapêutico
Ratos
Ratos Sprague-Dawley
Recidiva
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biological Products); 0 (Cytokines); 0 (Forkhead Transcription Factors); 0 (Foxp3 protein, rat); VB0R961HZT (Prednisone)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171220
[Lr] Data última revisão:
171220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171202
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-2021-8


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[PMID]:28800422
[Au] Autor:Tohtahon Z; Xue J; Han J; Liu Y; Hua H; Yuan T
[Ad] Endereço:The Key Laboratory of Plant Resources and Chemistry of Arid Zone, and State Key Laboratory of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 830011, China; University of Chinese Academy of Sciences
[Ti] Título:Cytotoxic lanostane triterpenoids from the fruiting bodies of Piptoporus betulinus.
[So] Source:Phytochemistry;143:98-103, 2017 Nov.
[Is] ISSN:1873-3700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Chemical investigation of a bioactive methanolic extract of the fruiting bodies of Piptoporus betulinus led to the isolation of five previously undescribed lanostane triterpenoids named piptolinic acids A-E, as well as five known lanostane triterpenoids. Their structures were elucidated on the basis of 1D and 2D NMR spectroscopic and HRESIMS analysis. Piptolinic acid A with an unusual moiety (3-hydroxy-4-methoxycarbonyl-3-methylbutyryloxy) at C-3 exhibited comparable cytotoxic activity against human promyelocytic leukemia cell line HL-60 (IC = 1.77 µM) and human acute monocytic leukemia cell line THP-1 (IC = 8.21 µM) to those of positive control, fluorouracil (IC = 6.38 and 4.41 µM, respectively).
[Mh] Termos MeSH primário: Antineoplásicos/isolamento & purificação
Antineoplásicos/farmacologia
Ganoderma/química
Triterpenos/isolamento & purificação
Triterpenos/farmacologia
[Mh] Termos MeSH secundário: Antineoplásicos/química
Coriolaceae/química
Ensaios de Seleção de Medicamentos Antitumorais
Carpóforos/química
Células HL-60
Seres Humanos
Estrutura Molecular
Ressonância Magnética Nuclear Biomolecular
Triterpenos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Triterpenes)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171002
[Lr] Data última revisão:
171002
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170812
[St] Status:MEDLINE


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[PMID]:28800421
[Au] Autor:Huang SZ; Ma QY; Kong FD; Guo ZK; Cai CH; Hu LL; Zhou LM; Wang Q; Dai HF; Mei WL; Zhao YX
[Ad] Endereço:Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agriculture Sciences, Haikou, 571101, People's Republic of China.
[Ti] Título:Lanostane-type triterpenoids from the fruiting body of Ganoderma calidophilum.
[So] Source:Phytochemistry;143:104-110, 2017 Nov.
[Is] ISSN:1873-3700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:To search for active anti-cancer constituents in the fruiting body of Ganoderma calidophilum, we have successfully isolated four previously undescribed spiro-lactone lanostane triterpenoids (spiroganocalitones A-D), two previously undescribed lanostanoids (ganodecalones A and B) together with twenty-three known ones. The structures of the six previously undescribed compounds were elucidated based on 1D, 2D-NMR, and HRMS analyses. Ganoderone A showed moderate cytotoxic activity against K562, BEL7402, and SGC790 cell lines with IC values of 7.62, 6.28, and 3.55 µM, respectively.
[Mh] Termos MeSH primário: Carpóforos/química
Ganoderma/química
Lanosterol/análogos & derivados
Triterpenos/isolamento & purificação
[Mh] Termos MeSH secundário: Seres Humanos
Concentração Inibidora 50
Lanosterol/química
Lanosterol/isolamento & purificação
Lanosterol/farmacologia
Estrutura Molecular
Ressonância Magnética Nuclear Biomolecular
Triterpenos/química
Triterpenos/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Triterpenes); 0 (lanostanoid); 1J05Z83K3M (Lanosterol)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171002
[Lr] Data última revisão:
171002
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170812
[St] Status:MEDLINE


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[PMID]:28661219
[Au] Autor:Yang Y; Nirmagustina DE; Kumrungsee T; Okazaki Y; Tomotake H; Kato N
[Ad] Endereço:a Graduate School of Biosphere Science , Hiroshima University , Higashi-Hiroshima , Japan.
[Ti] Título:Feeding of the water extract from Ganoderma lingzhi to rats modulates secondary bile acids, intestinal microflora, mucins, and propionate important to colon cancer.
[So] Source:Biosci Biotechnol Biochem;81(9):1796-1804, 2017 Sep.
[Is] ISSN:1347-6947
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Consumption of reishi mushroom has been reported to prevent colon carcinogenesis in rodents, although the underlying mechanisms remain unclear. To investigate this effect, rats were fed a high-fat diet supplemented with 5% water extract from either the reishi mushroom (Ganoderma lingzhi) (WGL) or the auto-digested reishi G. lingzhi (AWGL) for three weeks. Both extracts markedly reduced fecal secondary bile acids, such as lithocholic acid and deoxycholic acid (colon carcinogens). These extracts reduced the numbers of Clostridium coccoides and Clostridium leptum (secondary bile acids-producing bacteria) in a per g of cecal digesta. Fecal mucins and cecal propionate were significantly elevated by both extracts, and fecal IgA was significantly elevated by WGL, but not by AWGL. These results suggest that the reishi extracts have an impact on colon luminal health by modulating secondary bile acids, microflora, mucins, and propionate that related to colon cancer.
[Mh] Termos MeSH primário: Ácidos e Sais Biliares/metabolismo
Neoplasias do Colo
Ganoderma/química
Microbioma Gastrointestinal/efeitos dos fármacos
Mucinas/metabolismo
Propionatos/metabolismo
Água/química
[Mh] Termos MeSH secundário: Animais
Peso Corporal/efeitos dos fármacos
Ceco/efeitos dos fármacos
Ceco/microbiologia
Neoplasias do Colo/metabolismo
Neoplasias do Colo/microbiologia
Dieta
Ingestão de Alimentos/efeitos dos fármacos
Ácidos Graxos Voláteis/metabolismo
Fezes/química
Imunoglobulina A/metabolismo
Masculino
Ratos
Ratos Sprague-Dawley
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bile Acids and Salts); 0 (Fatty Acids, Volatile); 0 (Immunoglobulin A); 0 (Mucins); 0 (Propionates); 059QF0KO0R (Water)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170630
[St] Status:MEDLINE
[do] DOI:10.1080/09168451.2017.1343117


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[PMID]:28608696
[Au] Autor:Xiang QD; Yu Q; Wang H; Zhao MM; Liu SY; Nie SP; Xie MY
[Ad] Endereço:State Key Laboratory of Food Science and Technology, Nanchang University , Nanchang 330047, China.
[Ti] Título:Immunomodulatory Activity of Ganoderma atrum Polysaccharide on Purified T Lymphocytes through Ca /CaN and Mitogen-Activated Protein Kinase Pathway Based on RNA Sequencing.
[So] Source:J Agric Food Chem;65(26):5306-5315, 2017 Jul 05.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Our previous study has demonstrated that Ganoderma atrum polysaccharide (PSG-1) has immunomodulatory activity on spleen lymphocytes. However, how PSG-1 exerts its effect on purified lymphocytes is still obscure. Thus, this study aimed to investigate the immunomodulatory activity of PSG-1 on purified T lymphocytes and further elucidate the underlying mechanism based on RNA sequencing (RNA-seq). Our results showed that PSG-1 promoted T lymphocytes proliferation and increased the production of IL-2, IFN-γ, and IL-12. Meanwhile, RNA-seq analysis found 394 differentially expressed genes. KEGG pathway analysis identified 20 significant canonical pathways and seven biological functions. Furthermore, PSG-1 elevated intracellular Ca concentration and calcineurin (CaN) activity and raised the p-ERK, p-JNK, and p-p38 expression levels. T lymphocytes proliferation and the production of IL-2, IFN-γ, and IL-12 were decreased by the inhibitors of calcium channel and mitogen-activated protein kinases (MAPKs). These results indicated that PSG-1 possesses immunomodulatory activity on purified T lymphocytes, in which Ca /CaN and MAPK pathways play essential roles.
[Mh] Termos MeSH primário: Calcineurina/imunologia
Cálcio/imunologia
Ganoderma/química
Fatores Imunológicos/farmacologia
Extratos Vegetais/farmacologia
Polissacarídeos/farmacologia
Linfócitos T/efeitos dos fármacos
Verduras/química
[Mh] Termos MeSH secundário: Calcineurina/genética
Proliferação Celular/efeitos dos fármacos
Células Cultivadas
Interleucina-12/genética
Interleucina-12/imunologia
Interleucina-2/genética
Interleucina-2/imunologia
Proteína Quinase 3 Ativada por Mitógeno/genética
Proteína Quinase 3 Ativada por Mitógeno/imunologia
Análise de Sequência de RNA
Linfócitos T/imunologia
Proteínas Quinases p38 Ativadas por Mitógeno/genética
Proteínas Quinases p38 Ativadas por Mitógeno/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Immunologic Factors); 0 (Interleukin-2); 0 (Plant Extracts); 0 (Polysaccharides); 187348-17-0 (Interleukin-12); EC 2.7.11.24 (Mitogen-Activated Protein Kinase 3); EC 2.7.11.24 (p38 Mitogen-Activated Protein Kinases); EC 3.1.3.16 (Calcineurin); SY7Q814VUP (Calcium)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170721
[Lr] Data última revisão:
170721
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170614
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b01763


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[PMID]:28543056
[Au] Autor:Xu X; Chen X; Yu W; Liu Y; Zhang W; Lan J
[Ad] Endereço:Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
[Ti] Título:Cloning and analysis of the Glwc-1 and Glwc-2 genes encoding putative blue light photoreceptor from Ganoderma lucidum.
[So] Source:J Basic Microbiol;57(8):705-711, 2017 Aug.
[Is] ISSN:1521-4028
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Blue light plays an important role during the growth of Ganoderma lucidum, one of the best-known medicinal macrofungi in China. In the present study, we cloned Glwc-1 and Glwc-2, the homologue of the blue light photoreceptors Ncwc-1 and Ncwc-2 of Neurospora crassa, from G. lucidum. The deduced amino acid sequence of Glwc-1 contained the similar function domains as NcWC-1 including LOV, PAS B, PAS C, and PAC domains. The deduced amino acid sequence of Glwc-2 contained PAS domain and GATA-type zinc finger (Znf) domain as well as NcWC-2. Phylogenetic analysis based on fungal WC-1 and WC-2 supported GlWC-1 and GlWC-2 were blue light receptors. The expression of Glwc-1 and Glwc-2 indicated that they might play an important role during the primordium differentiation process of G. lucidum, and the external blue light stimulation increased the expression of Glwc-1 and Glwc-2.
[Mh] Termos MeSH primário: Ganoderma/genética
Genes Fúngicos
Fotorreceptores Microbianos/genética
[Mh] Termos MeSH secundário: Sítios de Ligação
Clonagem Molecular
DNA Fúngico/genética
Regulação Fúngica da Expressão Gênica
Luz
Neurospora crassa/genética
Filogenia
Alinhamento de Sequência
Fatores de Transcrição/metabolismo
Dedos de Zinco
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Fungal); 0 (Photoreceptors, Microbial); 0 (Transcription Factors)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171108
[Lr] Data última revisão:
171108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170526
[St] Status:MEDLINE
[do] DOI:10.1002/jobm.201700016


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[PMID]:28530827
[Au] Autor:Zhang DH; Jiang LX; Li N; Yu X; Zhao P; Li T; Xu JW
[Ad] Endereço:Faculty of Life Science and Technology, Kunming University of Science and Technology , Kunming, 650500, China.
[Ti] Título:Overexpression of the Squalene Epoxidase Gene Alone and in Combination with the 3-Hydroxy-3-methylglutaryl Coenzyme A Gene Increases Ganoderic Acid Production in Ganoderma lingzhi.
[So] Source:J Agric Food Chem;65(23):4683-4690, 2017 Jun 14.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The squalene epoxidase (SE) gene from the biosynthetic pathway of ganoderic acid (GA) was cloned and overexpressed in Ganoderma lingzhi. The strain that overexpressed the SE produced approximately 2 times more GA molecules than the wild-type (WT) strain. Moreover, SE overexpression upregulated lanosterol synthase gene expression in the biosynthetic pathway. These results indicated that SE stimulates GA accumulation. Then, the SE and 3-hydroxy-3-methylglutaryl coenzyme A (HMGR) genes were simultaneously overexpressed in G. lingzhi. Compared with the individual overexpression of SE or HMGR, the combined overexpression of the two genes further enhanced individual GA production. The overexpressing strain produced maximum GA-T, GA-S, GA-Mk, and GA-Me contents of 90.4 ± 7.5, 35.9 ± 5.4, 6.2 ± 0.5, and 61.8 ± 5.8 µg/100 mg dry weight, respectively. These values were 5.9, 4.5, 2.4, and 5.8 times higher than those produced by the WT strain. This is the first example of the successful manipulation of multiple biosynthetic genes to improve GA content in G. lingzhi.
[Mh] Termos MeSH primário: Acil Coenzima A/genética
Proteínas Fúngicas/genética
Ganoderma/metabolismo
Esqualeno Mono-Oxigenase/genética
Triterpenos/metabolismo
[Mh] Termos MeSH secundário: Acil Coenzima A/metabolismo
Vias Biossintéticas
Proteínas Fúngicas/metabolismo
Ganoderma/enzimologia
Ganoderma/genética
Expressão Gênica
Esqualeno Mono-Oxigenase/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acyl Coenzyme A); 0 (Fungal Proteins); 0 (Triterpenes); 0 (ganoderic acid); 1553-55-5 (3-hydroxy-3-methylglutaryl-coenzyme A); EC 1.14.14.17 (Squalene Monooxygenase)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170626
[Lr] Data última revisão:
170626
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170523
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b00629


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[PMID]:28504879
[Au] Autor:Isaka M; Chinthanom P; Sappan M; Supothina S; Vichai V; Danwisetkanjana K; Boonpratuang T; Hyde KD; Choeyklin R
[Ad] Endereço:National Center for Genetic Engineering and Biotechnology (BIOTEC) , 113 Thailand Science Park, Phaholyothin Road, Klong Luang, Pathumthani 12120, Thailand.
[Ti] Título:Antitubercular Activity of Mycelium-Associated Ganoderma Lanostanoids.
[So] Source:J Nat Prod;80(5):1361-1369, 2017 May 26.
[Is] ISSN:1520-6025
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In a continuation of our research into antitubercular lanostane triterpenoids from submerged cultures of Ganoderma species, three strains, Ganoderma orbiforme BCC 22325, Ganoderma sp. BCC 60695, and Ganoderma australe BCC 22314, have been investigated. Fourteen new lanostane triterpenoids, together with 35 known compounds, were isolated. Antitubercular activities of these mycelium-associated Ganoderma lanostanoids against Mycobacterium tuberculosis H37Ra were evaluated. Taken together with the assay data of previously isolated compounds, structure-activity relationships of the antitubercular activity are proposed. Most importantly, 3ß- and 15α-acetoxy groups were shown to be critical for antimycobacterial activity. The most potent compound was (24E)-3ß,15α-diacetoxylanosta-7,9(11),24-trien-26-oic acid (35).
[Mh] Termos MeSH primário: Antituberculosos/isolamento & purificação
Antituberculosos/farmacologia
Carpóforos/química
Ganoderma/isolamento & purificação
Lanosterol/análogos & derivados
Micélio/química
Mycobacterium tuberculosis/química
[Mh] Termos MeSH secundário: Antituberculosos/química
Ganoderma/química
Lanosterol/química
Lanosterol/isolamento & purificação
Lanosterol/farmacologia
Estrutura Molecular
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antitubercular Agents); 0 (lanostanoid); 1J05Z83K3M (Lanosterol)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170925
[Lr] Data última revisão:
170925
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170516
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jnatprod.6b00973



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