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  1 / 91 MEDLINE  
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[PMID]:27770452
[Au] Autor:Bogus MI; Wlóka E; Wronska A; Kaczmarek A; Kazek M; Zalewska K; Ligeza-Zuber M; Golebiowski M
[Ad] Endereço:Witold Stefanski Institute of Parasitology, Department of Molecular Biology, Polish Academy of Sciences, Warsaw, Poland.
[Ti] Título:Cuticle hydrolysis in four medically important fly species by enzymes of the entomopathogenic fungus Conidiobolus coronatus.
[So] Source:Med Vet Entomol;31(1):23-35, 2017 03.
[Is] ISSN:1365-2915
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Entomopathogenic fungi infect insects via penetration through the cuticle, which varies remarkably in chemical composition across species and life stages. Fungal infection involves the production of enzymes that hydrolyse cuticular proteins, chitin and lipids. Host specificity is associated with fungus-cuticle interactions related to substrate utilization and resistance to host-specific inhibitors. The soil fungus Conidiobolus coronatus (Constantin) (Entomophthorales: Ancylistaceae) shows virulence against susceptible species. The larvae and pupae of Calliphora vicina (Robineau-Desvoidy) (Diptera: Calliphoridae), Calliphora vomitoria (Linnaeus), Lucilia sericata (Meigen) (Diptera: Calliphoridae) and Musca domestica (Linnaeus) (Diptera: Muscidae) are resistant, but adults exposed to C. coronatus quickly perish. Fungus was cultivated for 3 weeks in a minimal medium. Cell-free filtrate, for which activity of elastase, N-acetylglucosaminidase, chitobiosidase and lipase was determined, was used for in vitro hydrolysis of the cuticle from larvae, puparia and adults. Amounts of amino acids, N-glucosamine and fatty acids released were measured after 8 h of incubation. The effectiveness of fungal enzymes was correlated with concentrations of compounds detected in the cuticles of tested insects. Positive correlations suggest compounds used by the fungus as nutrients, whereas negative correlations may indicate compounds responsible for insect resistance. Adult deaths result from the ingestion of conidia or fungal excretions.
[Mh] Termos MeSH primário: Exoesqueleto/microbiologia
Conidiobolus/fisiologia
Dípteros/microbiologia
Dípteros/fisiologia
[Mh] Termos MeSH secundário: Animais
Quitinases/metabolismo
Conidiobolus/enzimologia
Dípteros/crescimento & desenvolvimento
Feminino
Proteínas Fúngicas/metabolismo
Moscas Domésticas/crescimento & desenvolvimento
Moscas Domésticas/microbiologia
Moscas Domésticas/fisiologia
Hidrólise
Larva/crescimento & desenvolvimento
Larva/microbiologia
Larva/fisiologia
Lipase/metabolismo
Masculino
Peptídeo Hidrolases/metabolismo
Pupa/crescimento & desenvolvimento
Pupa/microbiologia
Pupa/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Fungal Proteins); EC 3.1.1.3 (Lipase); EC 3.2.1.14 (Chitinases); EC 3.4.- (Peptide Hydrolases)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171220
[Lr] Data última revisão:
171220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161023
[St] Status:MEDLINE
[do] DOI:10.1111/mve.12202


  2 / 91 MEDLINE  
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[PMID]:28258001
[Au] Autor:de Godoy I; de Campos CG; Pescador CA; Galceran JV; Cândido SL; Dutra V; Nakazato L
[Ad] Endereço:Laboratório de Microbiologia Veterinária, Universidade Federal de Mato Grosso (UFMT), Cuiabá, MT, Brazil. Electronic address: belinhagodoy@hotmail.com.
[Ti] Título:Experimental infection in gerbils by Conidiobolus lamprauges.
[So] Source:Microb Pathog;105:251-254, 2017 Apr.
[Is] ISSN:1096-1208
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Conidiobolomycosis is an emerging entomophthoramycosis caused by fungi Conidiobolus spp. Animal models are essential for the study of infectious disease in various areas such as pathogenesis, diagnostic methods, treatment and prevention. There is not currently an animal model for conidiobolomycosis. The aim of this study was to create an experimental infection protocol for Conidiobolus lamprauges in gerbils (Meriones unguiculatus). The study animals were randomly divided into four groups of four animals: immunosuppressed with cyclophosphamide (CPA) and infected with C. lamprauges (G1), immunocompetent and infected with C. lamprauges (G2), immunosuppressed with CPA (G3), and an immunocompetent control group (G4). Clinical signs were observed only in G1 animals, where the mortality rate reached 75% by day 7 after infection (AI) with a median survival of 2 days. C. lamprauges was detected only in G1, both by PCR and by isolation. Necropsies of the G1 animals showed lesions in the nasal cavity and lung tissue. These lesions were characterized by polymorphonuclear infiltrate cells and by the presence of hyphal structures under silver staining. This animal model will be useful for further investigation of diseases caused by C. lamprauges, particularly of those associated with immunosuppression factors in naturally occurring animal infections.
[Mh] Termos MeSH primário: Conidiobolus/isolamento & purificação
Modelos Animais de Doenças
Gerbillinae/microbiologia
Zigomicose/microbiologia
Zigomicose/veterinária
[Mh] Termos MeSH secundário: Animais
Conidiobolus/crescimento & desenvolvimento
Conidiobolus/patogenicidade
Ciclofosfamida/farmacologia
Hifas/crescimento & desenvolvimento
Hospedeiro Imunocomprometido
Pulmão/patologia
Cavidade Nasal/microbiologia
Cavidade Nasal/patologia
Reação em Cadeia da Polimerase/métodos
Distribuição Aleatória
Ovinos
Doenças dos Ovinos/microbiologia
Esporos Fúngicos/crescimento & desenvolvimento
Zigomicose/tratamento farmacológico
Zigomicose/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
8N3DW7272P (Cyclophosphamide)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170505
[Lr] Data última revisão:
170505
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170305
[St] Status:MEDLINE


  3 / 91 MEDLINE  
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[PMID]:28239908
[Au] Autor:Li Y; Fang X; Zhou X; Geng S; Wang Y; Yang X
[Ad] Endereço:Department of Dermatology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
[Ti] Título:Pathogenicity of Conidiobolus coronatus and Fusarium solani in mouse models.
[So] Source:Mycoses;60(6):394-401, 2017 Jun.
[Is] ISSN:1439-0507
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:To study the pathogenicity of Conidiobolus coronatus (C. coronatus) and Fusarium solani (F. solani) in animal models. Immunocompromised mice were treated with cyclophosphamide and prednisolone via intraperitoneal injection before and after inoculation. According to pathogenic characteristics of different fungi, C. coronatus was used to infect mice via intravenous inoculation, intraperitoneal inoculation, gastrointestinal infusion and intradermal inoculation methods. And F. solani was used to infect mice by inoculation via the abraded or normal skin. In the group of immunocompromised mice, C. coronatus was isolated from the lung tissues of one mouse on day 7 and another on day 10 respectively. The corresponding histopathology revealed infiltration of local inflammatory cells in the lung tissue. Pathogenic lesions were observed in all normal and immunocompromised mice infected with F. solani via abraded skin. The lesions in the immunocompromised mice were more severe and persisted longer than those in the normal mice. Moreover, hyphae were mostly observed in the histopathological examination and fungal culture from the immunocompromised mouse. The pathogenicity of C. coronatus was relatively weak as it did not induce local infections and did not disseminate the disease in immunocompetent and immunocompromised mice. Therefore, F. solani is a type of opportunistic pathogenic fungus, and abraded skin is one of the causative routes of infection.
[Mh] Termos MeSH primário: Conidiobolus/patogenicidade
Fusariose/patologia
Fusarium/patogenicidade
Zigomicose/patologia
[Mh] Termos MeSH secundário: Animais
Conidiobolus/efeitos dos fármacos
Ciclofosfamida/farmacologia
Modelos Animais de Doenças
Fusariose/tratamento farmacológico
Fusarium/efeitos dos fármacos
Hospedeiro Imunocomprometido
Imunossupressores/farmacologia
Pulmão/microbiologia
Pulmão/patologia
Masculino
Camundongos
Camundongos Endogâmicos ICR
Prednisolona/farmacologia
Pele/microbiologia
Pele/patologia
Zigomicose/tratamento farmacológico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Immunosuppressive Agents); 8N3DW7272P (Cyclophosphamide); 9PHQ9Y1OLM (Prednisolone)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170810
[Lr] Data última revisão:
170810
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170228
[St] Status:MEDLINE
[do] DOI:10.1111/myc.12607


  4 / 91 MEDLINE  
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[PMID]:28153464
[Au] Autor:Shukla E; Agrawal SB; Gaikwad SM
[Ad] Endereço:Academy of Scientific and Innovative Research (AcSIR), Division of Biochemical Sciences, CSIR-National Chemical laboratory, Pune 411008, India.
[Ti] Título:Conformational and functional transitions and in silico analysis of a serine protease from Conidiobolus brefeldianus (MTCC 5185).
[So] Source:Int J Biol Macromol;98:387-397, 2017 May.
[Is] ISSN:1879-0003
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:This work describes functional and structural transitions of a novel protease isolated from Conidiobolus brefeldianus MTCC 5185 (Cprot), in detail using biophysical and bioinformatics tools. The commercial importance of Cprot in silk and leather industries made it an interesting candidate for structural investigations. Cprot possesses 8.2% α-helix, 31.1% ß-sheet and 23.8% turns. The enzyme was found to be active over a wide pH range and up to 55°C. The protease was also stable in organic solvents up to 50% (v/v) concentration of alcohols and DMSO for >24h and in 2M guanidine hydrochloride for >12h. Cprot was also resistant to trypsin, chymotrypsin, proteinase K and fluorinated alcohols (5-10%). The melting temperatures observed for the native Cprot and for the enzyme treated under various stress conditions correlated well with the corresponding structural and functional transitions obtained. The structural information was supported by the homology model of its closest homologue from C. coronatus; revealing its similarity to PA clan of proteases (Proteases of mixed nucleophile, superfamily A), with His-64, Asp-113 and Ser-208 as putative catalytic triad. Three tryptophan residues in Cprot are surrounded by positively charged residues, as evident from solute quenching studies and homology model.
[Mh] Termos MeSH primário: Simulação por Computador
Conidiobolus/enzimologia
Serina Proteases/química
Serina Proteases/metabolismo
[Mh] Termos MeSH secundário: Estabilidade Enzimática/efeitos dos fármacos
Guanidina/farmacologia
Modelos Moleculares
Conformação Proteica
Desnaturação Proteica/efeitos dos fármacos
Homologia de Sequência de Aminoácidos
Solventes/farmacologia
Temperatura Ambiente
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Solvents); EC 3.4.- (Serine Proteases); JU58VJ6Y3B (Guanidine)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170417
[Lr] Data última revisão:
170417
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170204
[St] Status:MEDLINE


  5 / 91 MEDLINE  
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[PMID]:27697613
[Au] Autor:Desclaux A; Receveur MC; Lechot A; Le Bail B; Malvy D
[Ad] Endereço:Service des Maladies Infectieuses et Tropicales, Groupe Hospitalier Pellegrin, Place Amélie Raba-Léon, 33076 Bordeaux Cedex, France. Electronic address: arnaud.desclaux@chu-bordeaux.fr.
[Ti] Título:Swelling of the nose and upper lip in a young patient from the Comoro islands.
[So] Source:Travel Med Infect Dis;15:84-85, 2017 Jan - Feb.
[Is] ISSN:1873-0442
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Mh] Termos MeSH primário: Conidiobolus/isolamento & purificação
Dermatomicoses
Lábio
Nariz
Infecções dos Tecidos Moles
Zigomicose
[Mh] Termos MeSH secundário: Adulto
Antifúngicos/uso terapêutico
Comores
Seres Humanos
Lábio/diagnóstico por imagem
Lábio/microbiologia
Lábio/patologia
Masculino
Nariz/diagnóstico por imagem
Nariz/microbiologia
Nariz/patologia
Adulto Jovem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifungal Agents)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171024
[Lr] Data última revisão:
171024
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161005
[St] Status:MEDLINE


  6 / 91 MEDLINE  
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[PMID]:27444104
[Au] Autor:Bogus MI; Wieloch W; Ligeza-Zuber M
[Ad] Endereço:W. Stefanski Institute of Parasitology,Polish Academy of Sciences,Twarda 51/55,00-818 Warszawa,Poland.
[Ti] Título:Coronatin-2 from the entomopathogenic fungus Conidiobolus coronatus kills Galleria mellonella larvae and incapacitates hemocytes.
[So] Source:Bull Entomol Res;107(1):66-76, 2017 Feb.
[Is] ISSN:1475-2670
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Coronatin-2, a 14.5 kDa protein, was isolated from culture filtrates of the entomopathogenic fungus Conidiobolus coronatus (Costantin) Batko (Entomophthoramycota: Entomophthorales). After LC-MS/MS (liquid chromatography tandem mass spectrometry) analysis of the tryptic peptide digest of coronatin-2 and a mass spectra database search no orthologs of this protein could be found in fungi. The highest homology was observed to the partial translation elongation factor 1a from Sphaerosporium equinum (protein sequence coverage, 21%), with only one peptide sequence, suggesting that coronatin-2 is a novel fungal protein that has not yet been described. In contrast to coronatin-1, an insecticidal 36 kDa protein, which shows both elastolytic and chitinolytic activity, coronatin-2 showed no enzymatic activity. Addition of coronatin-2 into cultures of hemocytes taken from larvae of Galleria mellonella Linnaeus (Lepidoptera: Pyralidae), resulted in progressive disintegration of nets formed by granulocytes and plasmatocytes due to rapid degranulation of granulocytes, extensive vacuolization of plasmatocytes accompanied by cytoplasm expulsion, and cell disintegration. Spherulocytes remained intact, while oenocytes rapidly disintegrated. Coronatin-2 produced 80% mortality when injected into G. mellonella at 5 µg larva-1. Further study is warranted to determine the relevance of the acute toxicity of coronatin-2 and its effects on hemocytes in vitro to virulence of C. coronatus against its hosts.
[Mh] Termos MeSH primário: Conidiobolus/química
Proteínas Fúngicas/farmacologia
Inseticidas/farmacologia
Mariposas/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Cromatografia Líquida
Hemócitos/efeitos dos fármacos
Larva/efeitos dos fármacos
Larva/crescimento & desenvolvimento
Larva/microbiologia
Mariposas/crescimento & desenvolvimento
Mariposas/microbiologia
Espectrometria de Massas em Tandem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fungal Proteins); 0 (Insecticides)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170210
[Lr] Data última revisão:
170210
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160723
[St] Status:MEDLINE
[do] DOI:10.1017/S0007485316000638


  7 / 91 MEDLINE  
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[PMID]:27622620
[Au] Autor:Moncada DC; Montes M; Molina V; Velásquez JB; Gómez CI
[Ad] Endereço:Servicio de Medicina Interna, Universidad Pontificia Bolivariana, Medellín, Colombia. dianacmoncada@yahoo.es.
[Ti] Título:Orofacial infection by Conidiobolus coronatus.
[So] Source:Biomedica;36(0):15-22, 2016 Feb 23.
[Is] ISSN:0120-4157
[Cp] País de publicação:Colombia
[La] Idioma:eng
[Ab] Resumo:Entomophtoramycosis is a type of subcutaneous mycosis which includes both basidiobolomycosis and conidiobolomycosis; the latter is caused by Conidiobolus coronatus, a saprophytic fungus which lives in tropical soils. This mycosis characteristically affects the paranasal sinuses and oropharynx, with the potential to deform the face in patients without apparent immunodeficiency. It has a chronic course of infection with a tendency to form granulomas visible using histology. We present the case of a 28 year-old male agricultural worker, with a clinical profile of 6 months' evolution of rhinofacial tumefaction, nasal obstruction and post-nasal drip who was diagnosed with conidiobolomycosis by means of tissue culture after multiple biopsies of the facial area. The patient received antifungal treatment with amphotericin B and subsequently with itraconazol, resulting in a dramatic improvement without the need for surgical treatment; itraconazol was administered for one year and there was no evidence of relapse at the end of this period. Due to the low frequency of this disease there is no established treatment strategy; however, the use of azoles such as itraconazol with or without adjuvant surgical treatment is increasingly seen in case reports. The present report adds to the clinical experience in Colombia of this rare mycosis and also describes the long-term clinical and therapeutic response.
[Mh] Termos MeSH primário: Anfotericina B/uso terapêutico
Antifúngicos/uso terapêutico
Conidiobolus/efeitos dos fármacos
Dermatomicoses/fisiopatologia
Face/fisiopatologia
Granuloma/fisiopatologia
Itraconazol/uso terapêutico
[Mh] Termos MeSH secundário: Biópsia/normas
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifungal Agents); 304NUG5GF4 (Itraconazole); 7XU7A7DROE (Amphotericin B)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170622
[Lr] Data última revisão:
170622
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160914
[St] Status:MEDLINE
[do] DOI:10.7705/biomedica.v36i2.2806


  8 / 91 MEDLINE  
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[PMID]:27506454
[Au] Autor:Montalva C; Rocha LFN; Fernandes ÉKK; Luz C; Humber RA
[Ad] Endereço:Instituto de Patologia Tropical e Saúde Pública, Universidade Federal de Goiás, Goiânia, Goiás, Brazil; Facultad de Ciencias, Instituto de Bioquímica y Microbiología, Casilla 167, Universidad Austral de Chile, Valdivia, Chile. Electronic address: montalva.cristian@gmail.com.
[Ti] Título:Conidiobolus macrosporus (Entomophthorales), a mosquito pathogen in Central Brazil.
[So] Source:J Invertebr Pathol;139:102-108, 2016 Sep.
[Is] ISSN:1096-0805
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A new fungal pathogen of Culicinae (Diptera: Culicidae) adults, Conidiobolus macrosporus (Entomophthorales: Ancylistaceae), was detected and isolated during a survey of mosquito pathogens close to the city of Aruanã, Goiás State, in December 2014. The morphological characteristics of C. macrosporus are presented, and reasons for some uncertainty about this identification are discussed. The pathogenicity and high virulence of this fungus for Aedes aegypti were confirmed in laboratory conditions. Mortality of adults exposed to conidia was observed within 24h of exposure to the pathogen, and increased to 100% as quickly as 3days after inoculation (with the highest conidial concentration tested, 8.3×10(4)conidia/cm(2)). Repeated attempts to obtain genomic sequence data failed despite confirmations that the DNA extraction methods were themselves successful.
[Mh] Termos MeSH primário: Aedes/parasitologia
Conidiobolus/genética
Conidiobolus/patogenicidade
Zigomicose/veterinária
[Mh] Termos MeSH secundário: Animais
Brasil
Controle de Mosquitos/métodos
Controle Biológico de Vetores/métodos
Virulência
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160811
[St] Status:MEDLINE


  9 / 91 MEDLINE  
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[PMID]:27483450
[Au] Autor:Golebiowski M; Cerkowniak M; Ostachowska A; Naczk AM; Bogus MI; Stepnowski P
[Ad] Endereço:Laboratory of Analysis of Natural Compounds, Department of Environmental Analysis, Faculty of Chemistry, University of Gdansk, ul. Wita Stwosza 63, 80-308, Gdansk, Poland. marek.golebiowski@ug.edu.pl.
[Ti] Título:Effect of Conidiobolus coronatus on the Cuticular and Internal Lipid Composition of Tettigonia viridissima Males.
[So] Source:Chem Biodivers;13(8):982-9, 2016 Aug.
[Is] ISSN:1612-1880
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Conidiobolus coronatus is an entomopathogenic fungus which has a potential as a biological control agent of insects. The cuticular and internal lipid composition of infected and noninfected Tettigonia viridissima males were analyzed by GC/MS. A total of 49 compounds were identified in the infected and noninfected males, including fatty acids, fatty acid methyl esters (FAMEs), n-alkanes, alcohols, sterols, and other organic compounds. The most abundant components of the cuticular and internal lipids of the insects were fatty acids. After exposure to C. coronatus, the cuticular lipids of the T. viridissima males contained 17 free fatty acids from C(8) to C(22), while the cuticular lipids of the noninfected insects contained only 15 fatty acids from C(12) to C(24). The cuticular and internal lipids of both the infected and the noninfected males also contained five FAMEs from C(15) to C(19), seven n-alkanes from C(25) to C(34), five alcohols from C(16) to C(25), five sterols, and the following six other organic compounds: azelaic acid, phenylacetic acid, glutaric acid, benzoic acid, sebacic acid, and glycerol. The compounds which were present only in the cuticular lipids of the infected males could be due to fungal infection.
[Mh] Termos MeSH primário: Álcoois/análise
Alcanos/análise
Conidiobolus/química
Ésteres/análise
Ácidos Graxos/análise
Ortópteros/química
Esteróis/análise
[Mh] Termos MeSH secundário: Animais
Cromatografia Gasosa-Espectrometria de Massas
Masculino
Ortópteros/microbiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alcohols); 0 (Alkanes); 0 (Esters); 0 (Fatty Acids); 0 (Sterols)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170113
[Lr] Data última revisão:
170113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160803
[St] Status:MEDLINE
[do] DOI:10.1002/cbdv.201500316


  10 / 91 MEDLINE  
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[PMID]:26234812
[Au] Autor:Gupta M; Narang T; Kaur RJ; Manhas A; Saikia UN; Dogra S
[Ad] Endereço:Department of ENT, Gian Sagar Medical College & Hospital, Banur District, Patiala, Punjab, India.
[Ti] Título:A prospective case series evaluating efficacy and safety of combination of itraconazole and potassium iodide in rhinofacial conidiobolomycosis.
[So] Source:Int J Dermatol;55(2):208-14, 2016 Feb.
[Is] ISSN:1365-4632
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Rhinofacial conidiobolomycosis (RFC) is an uncommon subcutaneous fungal infection producing painless swelling with grotesque deformity of the face. Although there are case reports and small case series; there are very few prospective studies evaluating treatment outcome and long-term follow-up. OBJECTIVE: To evaluate the safety and efficacy of combination of itraconazole (200 mg twice daily) and saturated solution of potassium iodide (SSKI) in patients with RFC. METHODS: Ten patients of RFC were studied over a period of 5 years. Diagnosis was confirmed by clinical, histopathological, and microbiological evaluation. Conidiobolus was cultured in four cases and in the rest of the cases, the histopathology was suggestive of RFC. They were treated with itraconazole (200 mg twice daily) and SSKI and followed up for a minimum of 1 year after stopping treatment. RESULTS: The mean age was 38.7 years and the mean duration of symptoms was 22.4 months. Males were predominantly involved (9 : 1). Seven patients responded to the combination treatment, five had complete resolution and two had good improvement (50-75%); however, in two patients the response was minimal (<25% regression of the swelling) and one patient did not show any improvement after 6 months of treatment. CONCLUSION: Combination of itraconazole and SSKI is an effective treatment modality for RFC with relatively faster onset of action, low relapse rates, and minimal adverse effects. It can be considered as first-line treatment in patients with RFC.
[Mh] Termos MeSH primário: Antifúngicos/uso terapêutico
Conidiobolus
Dermatoses Faciais/tratamento farmacológico
Itraconazol/uso terapêutico
Iodeto de Potássio/uso terapêutico
Zigomicose/tratamento farmacológico
[Mh] Termos MeSH secundário: Adulto
Idoso
Antifúngicos/efeitos adversos
Quimioterapia Combinada
Dermatoses Faciais/microbiologia
Feminino
Seguimentos
Seres Humanos
Itraconazol/efeitos adversos
Masculino
Meia-Idade
Doenças Nasais/tratamento farmacológico
Doenças Nasais/microbiologia
Iodeto de Potássio/efeitos adversos
Estudos Prospectivos
Resultado do Tratamento
Adulto Jovem
Zigomicose/microbiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifungal Agents); 1C4QK22F9J (Potassium Iodide); 304NUG5GF4 (Itraconazole)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150804
[St] Status:MEDLINE
[do] DOI:10.1111/ijd.12966



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