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Pesquisa : B01.300.300.500.030 [Categoria DeCS]
Referências encontradas : 175 [refinar]
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[PMID]:28428022
[Au] Autor:Wang R; Sui P; Hou X; Cao T; Jia L; Lu F; Singh S; Wang Z; Liu X
[Ad] Endereço:College of Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, China.
[Ti] Título:Cloning and identification of a novel steroid 11α-hydroxylase gene from Absidia coerulea.
[So] Source:J Steroid Biochem Mol Biol;171:254-261, 2017 Jul.
[Is] ISSN:1879-1220
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Steroid 11-hydroxylation by filamentous fungi is a major route for industrial scale production of key intermediates in the synthesis of steroid drugs. Although it is well established that enzymes involved in fungal hydroxylation of steroids are cytochrome P450s (CYP), few fungal steroid hydroxylase genes have been identified. In this study, we identified a novel 11α-hydroxylase gene CYP5311B1 from Absidia coerulea AS3.65 by a combination of transcriptome sequencing, real-time qRT-PCR and heterologous expression in Pichia pastoris. The full-length open reading frame (ORF) of CYP5311B1 is predicted to encode a CYP protein of 527 amino acids whose expression in Pichia cells was confirmed by western blot. In addition, the major hydroxylation product was characterized by HPLC and 2D NMR. CYP5311B1 was highly induced by steroid substrate at the transcriptional level. The cloning and identification of an 11α-hydroxylase gene from A. coerulea should aid in a better understanding of the structural basis underlying regio- and stereoselectivity, and substrate specificity of fungal steroid 11α-hydroxylases, thus facilitating the engineering of more efficient steroid hydroxylases for industrial applications.
[Mh] Termos MeSH primário: Absidia/enzimologia
Proteínas Fúngicas/metabolismo
Esteroide Hidroxilases/metabolismo
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Células Clonais
Eletroporação
Indução Enzimática
Compostos de Epóxi/química
Compostos de Epóxi/metabolismo
Escherichia coli
Proteínas Fúngicas/genética
Hidroxilação
Estrutura Molecular
Fases de Leitura Aberta
Filogenia
Pichia
Progesterona/análogos & derivados
Progesterona/química
Progesterona/metabolismo
Proteínas Recombinantes/metabolismo
Alinhamento de Sequência
Análise de Sequência de RNA
Homologia de Sequência de Aminoácidos
Estereoisomerismo
Esteroide Hidroxilases/genética
Terminologia como Assunto
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Epoxy Compounds); 0 (Fungal Proteins); 0 (Recombinant Proteins); 1097-51-4 (16 alpha,17-epoxyprogesterone); 4G7DS2Q64Y (Progesterone); EC 1.14.- (Steroid Hydroxylases); EC 1.14.99.- (steroid 11-alpha-hydroxylase)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170718
[Lr] Data última revisão:
170718
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170422
[St] Status:MEDLINE


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[PMID]:28106750
[Au] Autor:Winska K; Grabarczyk M; Maczka W; Kondas A; Maciejewska G; Bonikowski R; Aniol M
[Ad] Endereço:Department of Chemistry, Wroclaw University of Environmental and Life Sciences, Norwida 25, 50-375 Wroclaw, Poland. katarzyna.winska@upwr.edu.pl.
[Ti] Título:Synthesis and Biotransformation of Bicyclic Unsaturated Lactones with Three or Four Methyl Groups.
[So] Source:Molecules;22(1), 2017 Jan 17.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:The aim of this study was to obtain new unsaturated lactones by chemical synthesis and their microbial transformations using fungal strains. Some of these strains were able to transform unsaturated lactones into different hydroxy or epoxy derivatives. Strains of and gave products with a hydroxy group introduced into a tertiary carbon, while the strain hydroxylated primary carbons. The strain hydroxylated both substrates in an allylic position. Using the and strains led to the obtained epoxylactones. The structures of all lactones were established on the basis of spectroscopic data.
[Mh] Termos MeSH primário: Biotransformação
Lactonas/síntese química
Lactonas/metabolismo
[Mh] Termos MeSH secundário: Absidia/metabolismo
Hidroxilação
Mucorales/metabolismo
Penicillium/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Lactones)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170512
[Lr] Data última revisão:
170512
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170121
[St] Status:MEDLINE


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[PMID]:28054950
[Au] Autor:Sordon S; Poplonski J; Tronina T; Huszcza E
[Ad] Endereço:Department of Chemistry, Wroclaw University of Environmental and Life Sciences, Norwida 25, 50-375 Wroclaw, Poland. sandra.sordon@wp.pl.
[Ti] Título:Microbial Glycosylation of Daidzein, Genistein and Biochanin A: Two New Glucosides of Biochanin A.
[So] Source:Molecules;22(1), 2017 Jan 03.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Biotransformation of daidzein, genistein and biochanin A by three selected filamentous fungi was investigated. As a result of biotransformations, six glycosylation products were obtained. Fungus converted all tested isoflavones to 4″- -methyl-7- -glucosyl derivatives, whereas and were able to transform genistein and biochanin A to genistin and sissotrin, respectively. In the culture of , in addition to the sissotrin, the product of glucosylation at position 5 was formed. Two of the obtained compounds have not been published so far: 4″- -methyl-7- -glucosyl biochanin A and 5- glucosyl biochanin A (isosissotrin). Biotransformation products were obtained with 22%-40% isolated yield.
[Mh] Termos MeSH primário: Absidia/metabolismo
Beauveria/metabolismo
Reatores Biológicos/microbiologia
Genisteína/metabolismo
Isoflavonas/metabolismo
[Mh] Termos MeSH secundário: Biotransformação/fisiologia
Fermentação/fisiologia
Glicosilação
Isoflavonas/biossíntese
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Isoflavones); 1POG3SCN5T (genistin); 6287WC5J2L (daidzein); DH2M523P0H (Genistein); U13J6U390T (biochanin A)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170523
[Lr] Data última revisão:
170523
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170106
[St] Status:MEDLINE


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[PMID]:27788595
[Au] Autor:Han F; Lee IS
[Ad] Endereço:a College of Pharmacy and Research Institute of Drug Development , Chonnam National University , Gwangju , Republic of Korea.
[Ti] Título:Microbial transformation of the antimalarial sesquiterpene endoperoxide dihydroartemisinin.
[So] Source:Nat Prod Res;31(8):883-889, 2017 Apr.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Dihydroartemisinin (DHA, 1), a sesquiterpene endoperoxide derived from artemisinin, has shown potent antimalarial and anticancer activities. Microbial transformation of DHA by Absidia coerulea and Penicillium chrysogenum yielded one new (3) and four known metabolites (2, 4-6). The chemical structures of these compounds were identified as deoxydihydroartemisinin (2), 8α-hydroxydeoxyartemisinin (3), deoxyartemisinin (4), 9α-hydroxyartemethin-I (5) and 3α-hydroxydeoxydihydroartemisinin (6) using spectroscopic analyses. Among them, compounds 3 and 4 are artemisinin analogues, which were achieved by unusual oxidation at C-12 position. Biotransformation of DHA by microorganisms was an effective approach to obtain new derivatives of DHA.
[Mh] Termos MeSH primário: Absidia/metabolismo
Antimaláricos/metabolismo
Artemisininas/metabolismo
Penicillium chrysogenum/metabolismo
[Mh] Termos MeSH secundário: Antimaláricos/química
Artemisininas/química
Biotransformação
Estrutura Molecular
Oxirredução
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antimalarials); 0 (Artemisinins); 6A9O50735X (dihydroartemisinin); 72826-63-2 (deoxyartemisinin); 9RMU91N5K2 (artemisinine)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161030
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2016.1250092


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[PMID]:26922501
[Au] Autor:Kristanti RA; Fikri Ahmad Zubir MM; Hadibarata T
[Ad] Endereço:Faculty of Engineering Technology, Universiti Malaysia Pahang, Lebuhraya Tun Razak, 26300 Gambang, Kuantan, Pahang, Malaysia.
[Ti] Título:Biotransformation studies of cresol red by Absidia spinosa M15.
[So] Source:J Environ Manage;172:107-11, 2016 May 01.
[Is] ISSN:1095-8630
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Cresol Red, a commercial dye that used widely to color nylon, wool, cotton, and polyacrylonitrile-modified nylon in the massive textile manufacture is toxic recalcitrant. Absidia spinosa M15, a novel fungal strain isolated from a tropical rain forest, was found to decolorize Cresol Red 65% within 30 d under agitation condition. UV-Vis spectroscopy, TLC analysis and mass spectra of samples after decolorization process in culture medium confirmed final decolorization of Cresol Red. Two metabolites were identified in the treated medium: benzeneacetic acid (tR 9.6 min and m/z 136) and benzoic acid (tR 5.7 min and m/z 122). Laccase showed the significant activity (133.8 U/L) in biomass obtained at the end of experiment demonstrates role of the enzyme in the decolorization process.
[Mh] Termos MeSH primário: Absidia/metabolismo
Corantes/metabolismo
Fenolsulfonaftaleína/análogos & derivados
Poluentes Químicos da Água/metabolismo
[Mh] Termos MeSH secundário: Ácido Benzoico/metabolismo
Biodegradação Ambiental
Biotransformação
Cor
Cromatografia Gasosa-Espectrometria de Massas
Lacase/metabolismo
Fenolsulfonaftaleína/metabolismo
Fenilacetatos/metabolismo
Floresta Úmida
Espectrofotometria Ultravioleta
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Coloring Agents); 0 (Phenylacetates); 0 (Water Pollutants, Chemical); 839K2R4B8K (Cresol red); 8SKN0B0MIM (Benzoic Acid); EC 1.10.3.2 (Laccase); I6G9Y0J1OJ (Phenolsulfonphthalein)
[Em] Mês de entrada:1611
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160229
[St] Status:MEDLINE


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[PMID]:26263626
[Au] Autor:Feofilova EP; Sergeeva YE; Mysyakina IS; Bokareva DA
[Ti] Título:[Lipid Composition in Cell Walls and in Mycelial and Spore Cells of Mycelial Fungi].
[So] Source:Mikrobiologiia;84(2):204-11, 2015 Mar-Apr.
[Is] ISSN:0026-3656
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:Qualitative and quantitative differences were found between the lipids of cell walls (CW) and of whole mycelial cells and dormant cells of mucoraceous and ascomycete fungi. Thus, whole mycelial cells (WC) contained more lipids than CW. Unlike sporangiospores and conidia (exogenous dormant spores), zygotes were found to have the highest content of triacylglycerol lipids (70%). Cell walls of mucoraceous fungi contained more triacylglycerols (TAG) and less polar lipids than ascomycete lipids. While all CW and WC studied were similar in fatty acid (FA) composition, their ratio was specific for each structure: linoleic acid predominated in mycelial CW and WC, while oleic acid was predominant in the spores; this difference was especially pronounced in conidial WC. Unlike WC, in CW massive lipids may be represented not by phosphatidylethanolamine (PEA) and phosphatidylcholine (PC), but by free fatty acids (FFA), free (FSt) and etherified sterols (ESt), phosphatidic acid (PA), fatty acid methyl esters (FAME), and glycolipids (GL), which is an indication of a special functional role of CW.
[Mh] Termos MeSH primário: Absidia/química
Parede Celular/química
Cunninghamella/química
Micélio/química
Penicillium/química
Esporos Fúngicos/química
[Mh] Termos MeSH secundário: Absidia/crescimento & desenvolvimento
Cromatografia em Camada Delgada
Meios de Cultura
Cunninghamella/crescimento & desenvolvimento
Glicolipídeos/isolamento & purificação
Ácido Linoleico/isolamento & purificação
Micélio/crescimento & desenvolvimento
Ácido Oleico/isolamento & purificação
Penicillium/crescimento & desenvolvimento
Ácidos Fosfatídicos/isolamento & purificação
Fosfatidilcolinas/isolamento & purificação
Fosfatidiletanolaminas/isolamento & purificação
Esporos Fúngicos/crescimento & desenvolvimento
Esteróis/isolamento & purificação
Triglicerídeos/isolamento & purificação
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Culture Media); 0 (Glycolipids); 0 (Phosphatidic Acids); 0 (Phosphatidylcholines); 0 (Phosphatidylethanolamines); 0 (Sterols); 0 (Triglycerides); 2UMI9U37CP (Oleic Acid); 39382-08-6 (phosphatidylethanolamine); 9KJL21T0QJ (Linoleic Acid)
[Em] Mês de entrada:1508
[Cu] Atualização por classe:150812
[Lr] Data última revisão:
150812
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150813
[St] Status:MEDLINE


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[PMID]:25868124
[Au] Autor:Ermis E; Hertel C; Schneider C; Carle R; Stintzing F; Schmidt H
[Ad] Endereço:Institute of Food Science and Biotechnology, Food Microbiology and Hygiene, Hohenheim University, 70599 Stuttgart, Germany.
[Ti] Título:Characterization of in vitro antifungal activities of small and American cranberry (Vaccinium oxycoccos L. and V. macrocarpon Aiton) and lingonberry (Vaccinium vitis-idaea L.) concentrates in sugar reduced fruit spreads.
[So] Source:Int J Food Microbiol;204:111-7, 2015 Jul 02.
[Is] ISSN:1879-3460
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:In this study, cranberry and lingonberry concentrates were added to commercial sugar-reduced fruit spreads (raspberry-Aloe vera, strawberry-guava, and strawberry-lime), and tested for their antifungal activities. Selected strains of the species Absidia glauca, Penicillium brevicompactum, Saccharomyces cerevisiae and Zygosaccharomyces bailii, as well as xerophilic environmental isolates of the genera Penicillium and Eurotium were used for challenge testing. Initially, varying concentrations of synthetic antifungal agents, such as sodium benzoate, potassium sorbate and butyl 4-hydroxybenzoate were tested against these fungi on wort agar containing 31% fructose at different pH values. Subsequently, the experiments were conducted in fruit spreads containing different concentrations of cranberry and lingonberry concentrates. The results of this study demonstrate that these concentrates were able to inhibit growth of visible colonies of xerophilic and non-xerophilic fungi. Cranberry and lingonberry concentrates are interesting candidates for natural preservation against fungal growth in sugar reduced fruit spreads.
[Mh] Termos MeSH primário: Antifúngicos/farmacologia
Contaminação de Alimentos/prevenção & controle
Extratos Vegetais/farmacologia
Vaccinium macrocarpon/metabolismo
Vaccinium vitis-Idaea/metabolismo
[Mh] Termos MeSH secundário: Absidia/efeitos dos fármacos
Aloe/microbiologia
Carboidratos/análise
Citrus aurantiifolia/microbiologia
Fragaria/microbiologia
Frutas/química
Frutas/microbiologia
Técnicas In Vitro
Testes de Sensibilidade Microbiana
Parabenos/farmacologia
Penicillium/efeitos dos fármacos
Psidium/microbiologia
Rubus/microbiologia
Saccharomyces cerevisiae/efeitos dos fármacos
Benzoato de Sódio/farmacologia
Ácido Sórbico/farmacologia
Estados Unidos
Zygosaccharomyces/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (Carbohydrates); 0 (Parabens); 0 (Plant Extracts); JG8Z55Y12H (4-hydroxybenzoic acid); OJ245FE5EU (Sodium Benzoate); X045WJ989B (Sorbic Acid)
[Em] Mês de entrada:1510
[Cu] Atualização por classe:150424
[Lr] Data última revisão:
150424
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150414
[St] Status:MEDLINE


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[PMID]:25498025
[Au] Autor:Pang X; Wen D; Zhao Y; Xiong CQ; Wang XQ; Yu LY; Ma BP
[Ad] Endereço:Department of Biotechnology, Beijing Institute of Radiation Medicine, No. 27 Taiping Road, Haidian District, Beijing 100850, China; Center for Culture Collection of Pharmaceutical Microorganisms, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical Col
[Ti] Título:Steroidal saponins obtained by biotransformation of total furostanol glycosides from Dioscorea zingiberensis with Absidia coerulea.
[So] Source:Carbohydr Res;402:236-40, 2015 Jan 30.
[Is] ISSN:1873-426X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Five new steroidal saponins (1-5) were isolated from the fermentation broth of total furostanol glycosides from tubers of Dioscorea zingiberensis C.H. Wright incubated with a fungal, Absidia coerulea AS 3.3389, along with known saponins, zingiberensis new saponin (6), deltonin (7), prosapogenin A of dioscin (8), and protobioside (9), and their structures were established by NMR spectroscopy and mass spectrometry as well as by comparison with previously reported spectral data in the literatures. The induced effects in vitro on rat platelet aggregation of all compounds were evaluated.
[Mh] Termos MeSH primário: Absidia/metabolismo
Dioscorea/química
Glicosídeos/metabolismo
Saponinas/química
Saponinas/metabolismo
Esteroides/química
Esteróis/metabolismo
[Mh] Termos MeSH secundário: Animais
Biotransformação
Fermentação
Masculino
Estruturas Vegetais/química
Agregação Plaquetária/efeitos dos fármacos
Ratos
Ratos Wistar
Saponinas/isolamento & purificação
Saponinas/farmacologia
Amido/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Glycosides); 0 (Saponins); 0 (Steroids); 0 (Sterols); 0 (furostanol glycoside); 9005-25-8 (Starch)
[Em] Mês de entrada:1508
[Cu] Atualização por classe:141230
[Lr] Data última revisão:
141230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141216
[St] Status:MEDLINE


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[PMID]:25443187
[Au] Autor:Mesa Varona D; Celis Sánchez J; Alfaya Muñoz L; Avendaño Cantos EM; Romero Moraleda L
[Ad] Endereço:FEA oftalmología,.Unidad de Superficie ocular y Córnea., Hospital La Mancha Centro, Alcázar de San Juan, Ciudad Real, España. Electronic address: dimeva23@hotmail.com.
[Ti] Título:Keratitis caused by Absidia corymbifera in an immunocompetent male with no corneal injuries.
[So] Source:Arch Soc Esp Oftalmol;90(3):139-41, 2015 Mar.
[Is] ISSN:1989-7286
[Cp] País de publicação:Spain
[La] Idioma:eng; spa
[Ab] Resumo:Case Report A healthy 55-years-old male went to emergency due to a white infiltrate in the left eye without corneal trauma which partially responds to antibiotic treatment. The infiltrate worsened by the use of topical steroids. Direct microscopic evaluation and Gram stain are a valuable diagnostic tool for the detection of Absidia filaments. There is a successful treatment with anphotericin and posaconazole. Discussion Keratitis caused by Zygomicetes are unusual. This is a rare condition in healthy patients with no corneal trauma. The treatment with amphotericin and posaconazole are synergistic against filamentous fungi.
[Mh] Termos MeSH primário: Absidia/isolamento & purificação
Úlcera da Córnea/etiologia
Mucormicose/microbiologia
[Mh] Termos MeSH secundário: Absidia/efeitos dos fármacos
Administração Oftálmica
Corticosteroides/efeitos adversos
Anfotericina B/uso terapêutico
Antibacterianos/uso terapêutico
Antifúngicos/uso terapêutico
Terapia Combinada
Transplante de Córnea
Úlcera da Córnea/tratamento farmacológico
Úlcera da Córnea/microbiologia
Úlcera da Córnea/cirurgia
Quimioterapia Combinada
Seres Humanos
Imunocompetência
Masculino
Meia-Idade
Mucormicose/diagnóstico
Mucormicose/tratamento farmacológico
Soluções Oftálmicas
Coloração e Rotulagem
Triazóis/uso terapêutico
Voriconazol/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Adrenal Cortex Hormones); 0 (Anti-Bacterial Agents); 0 (Antifungal Agents); 0 (Ophthalmic Solutions); 0 (Triazoles); 6TK1G07BHZ (posaconazole); 7XU7A7DROE (Amphotericin B); JFU09I87TR (Voriconazole)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170110
[Lr] Data última revisão:
170110
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141203
[St] Status:MEDLINE


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[PMID]:25027724
[Au] Autor:Mazur M; Grudniewska A; Wawrzenczyk C
[Ad] Endereço:Department of Chemistry, Wroclaw University of Environmental and Life Sciences, Norwida 25, 50-375 Wroclaw, Poland. Electronic address: marcelina.mazur@up.wroc.pl.
[Ti] Título:Microbial transformations of halolactones with p-menthane system.
[So] Source:J Biosci Bioeng;119(1):72-6, 2015 Jan.
[Is] ISSN:1347-4421
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Biologically active piperitone-derived racemic iodo-, bromo- and chlorolactones (1-3) were transformed with the use of microbial enzymatic systems. Four strains of filamentous fungi Absidia glauca AM254, Absidia cylindrospora AM336, Mortierella vinaceae AM149 and Nigrospora oryzae AM8 transformed halolactones (1-3) to four new halohydroxylactones (4-7). In all biotransformations the hydroxy group was incorporated in inactivated methine carbon atom at isopropyl substituent. In N. oryzae AM8 culture the bromolactone with additional hydroxy group in α-position, relative to CO bond in γ-lactone ring, was also formed as a product. The structures of new compounds were established on the basis of spectral data.
[Mh] Termos MeSH primário: Absidia/metabolismo
Lactonas/metabolismo
Metano/metabolismo
[Mh] Termos MeSH secundário: Absidia/classificação
Biotransformação
Hidroxilação
Lactonas/química
Monoterpenos/química
Monoterpenos/metabolismo
Terpenos/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Lactones); 0 (Monoterpenes); 0 (Terpenes); 0 (piperitone); OP0UW79H66 (Methane)
[Em] Mês de entrada:1506
[Cu] Atualização por classe:141229
[Lr] Data última revisão:
141229
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140717
[St] Status:MEDLINE



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