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Pesquisa : B01.300.360.500.500.100.175.175 [Categoria DeCS]
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[PMID]:28942047
[Au] Autor:Kotková M; Sak B; Hlásková L; Kvác M
[Ad] Endereço:Institute of Parasitology, Biology Centre, Czech Academy of Sciences, Ceské Budejovice, Czech Republic; Faculty of Agriculture, University of South Bohemia in Ceské Budejovice, Ceské Budejovice, Czech Republic.
[Ti] Título:The course of infection caused by Encephalitozoon cuniculi genotype III in immunocompetent and immunodeficient mice.
[So] Source:Exp Parasitol;182:16-21, 2017 Nov.
[Is] ISSN:1090-2449
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Encephalitozoon cuniculi is probably the most common microsporidia which infects a wide range of vertebrates, including human. So far, four genotypes of this parasite have been identified based on the rRNA internal transcribed spacer variations. The course of infection caused by E. cuniculi III had very massive onset in immunocompetent host characterized by the presence of this parasite in all organs and tissues within one week after peroral infection. Encephalitozoonosis caused by E. cuniculi III had very progressive spreading into all organs within first week post inoculation in immunocompromised SCID mice and led to the death of the host. The experimental treatment with albendazole of immunocompetent BALB/c mice infected with E. cuniculi III have shown very weak effect. Our findings clearly showed that the different course of infection and response to treatment depends not only on the immunological status of the host, but also on the genotype of microsporidia. It could be very important especially for individuals under chemotherapy and transplant recipients of organs originating from infected donors.
[Mh] Termos MeSH primário: Albendazol/uso terapêutico
Encephalitozoon cuniculi/fisiologia
Encefalitozoonose/imunologia
Imunocompetência
Hospedeiro Imunocomprometido
[Mh] Termos MeSH secundário: Albendazol/farmacologia
Animais
Antifúngicos/farmacologia
Antifúngicos/uso terapêutico
Encephalitozoon cuniculi/efeitos dos fármacos
Encephalitozoon cuniculi/genética
Encephalitozoon cuniculi/imunologia
Encefalitozoonose/tratamento farmacológico
Encefalitozoonose/parasitologia
Fezes/parasitologia
Genótipo
Camundongos
Camundongos Endogâmicos BALB C
Camundongos SCID
Esporos Fúngicos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifungal Agents); F4216019LN (Albendazole)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170925
[St] Status:MEDLINE


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[PMID]:28779899
[Au] Autor:Sak B; Jandová A; Dolezal K; Kvác M; Kvetonová D; Hlásková L; Rost M; Olsanský M; Nurcahyo W; Foitová I
[Ad] Endereço:Institute of Parasitology, Biology Centre, Czech Academy of Sciences, Ceské Budejovice, Czech Republic. Electronic address: casio@paru.cas.cz.
[Ti] Título:Effects of selected Indonesian plant extracts on E. cuniculi infection in vivo.
[So] Source:Exp Parasitol;181:94-101, 2017 Oct.
[Is] ISSN:1090-2449
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The present study was conducted to evaluate the methanolic extracts from several plant leaves widely used in traditional medicine to cure digestive tract disorders and in the self-medication of wild animals such as non-human primates, namely Archidendron fagifolium, Diospyros sumatrana, Shorea sumatrana, and Piper betle leaves, with regard to their antimicrosporidial activity against Encephalitozoon cuniculi in immunocompetent BALB/c mice determined using molecular detection of microsporidial DNA (qPCR) in various tissues and body fluids of infected, treated mice. Of the plant extracts tested, Diospyros sumatrana provided the most promising results, reducing spore shedding by 88% compared to untreated controls. Moreover, total burden per 1 g of tissue in the D. sumatrana extract-treated group reached 87% reduction compared to untreated controls, which was comparable to the effect of the standard drug, Albendazole. This data represents the baseline necessary for further research focused on determining the structure, activity and modes of action of the active compounds, mainly of D. sumatrana, enabling subsequent development of antimicrosporidial remedies.
[Mh] Termos MeSH primário: Antifúngicos/uso terapêutico
Diospyros/química
Encephalitozoon cuniculi/efeitos dos fármacos
Encefalitozoonose/tratamento farmacológico
Extratos Vegetais/uso terapêutico
[Mh] Termos MeSH secundário: Albendazol/farmacologia
Albendazol/uso terapêutico
Animais
Antifúngicos/farmacologia
Cercopithecus aethiops
DNA Fúngico/isolamento & purificação
Dimetil Sulfóxido/farmacologia
Dimetil Sulfóxido/uso terapêutico
Dipterocarpaceae/química
Fabaceae/química
Fezes/parasitologia
Trato Gastrointestinal/microbiologia
Imunocompetência
Indonésia
Camundongos
Camundongos Endogâmicos BALB C
Piper betle/química
Extratos Vegetais/farmacologia
Folhas de Planta/química
Esporos Fúngicos/efeitos dos fármacos
Células Vero
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (DNA, Fungal); 0 (Plant Extracts); F4216019LN (Albendazole); YOW8V9698H (Dimethyl Sulfoxide)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170920
[Lr] Data última revisão:
170920
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170807
[St] Status:MEDLINE


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[PMID]:28723944
[Au] Autor:Desoubeaux G; Piqueras MDC; Pantin A; Bhattacharya SK; Peschke R; Joachim A; Cray C
[Ad] Endereço:University of Miami - Miller School of Medicine, Division of Comparative Pathology, Department of Pathology & Laboratory Medicine, Miami, Florida, United States of America.
[Ti] Título:Application of mass spectrometry to elucidate the pathophysiology of Encephalitozoon cuniculi infection in rabbits.
[So] Source:PLoS One;12(7):e0177961, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Encephalitozoon cuniculi is a microsporidian species which can induce subclinical to serious disease in mammals including rabbits, a definitive natural host. The pathophysiology of infection has not been comprehensively elucidated. In this exploratory study, we utilized two mass spectrometry approaches: first, the analysis of the humoral response by profiling the microsporidian antigens as revealed by Western blot screening, and second, implementing the iTRAQ®-labeling protocol to focus on the changes within the host proteome during infection. Seven E. cuniculi proteins were identified at one-dimensional gel regions where specific seropositive reaction was observed by Western blot, including polar tube protein 3, polar tube protein 2, and for the first time reported: heat shock related 70kDa protein, polysaccharide deacetylase domain-containing protein, zinc finger protein, spore wall and anchoring disk complex protein EnP1, and translation elongation factor 1 alpha. In addition, there was a significant increase of nine host proteins in blood samples from E. cuniculi-diseased rabbits in comparison with non-diseased control subjects undergoing various inflammatory processes. This included serum paraoxonase, alpha-1-antiproteinase F precursor and alpha-1-antiproteinase S-1 which have presumptive catalytic activity likely related to infection control, and cystatin fetuin-B-type, an enzyme regulator that has been poorly studied to date. Notably, 11 proteins were found to be statistically increased in rabbits with neurological versus renal clinical presentation of E. cuniculi infection. Overall, this novel analysis based on mass spectrometry has provided new insights on the inflammatory and humoral responses during E. cuniculi infection in rabbits.
[Mh] Termos MeSH primário: Encephalitozoon cuniculi/isolamento & purificação
Encefalitozoonose/veterinária
Proteínas Fúngicas/metabolismo
[Mh] Termos MeSH secundário: Animais
Encefalitozoonose/metabolismo
Encefalitozoonose/microbiologia
Espectrometria de Massas
Coelhos
Esporos Fúngicos/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fungal Proteins)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170721
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0177961


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[PMID]:28205456
[Au] Autor:Rodríguez-Tovar LE; Villarreal-Marroquín A; Nevárez-Garza AM; Castillo-Velázquez U; Rodríguez-Ramírez HG; Navarro-Soto MC; Zárate-Ramos JJ; Hernández-Vidal G; Trejo-Chávez A
[Ad] Endereço:Cuerpo Académico de Zoonosis y Enfermedades Emergentes (Rodríguez, Villarreal, Nevárez, Castillo, Rodríguez, Navarro, Trejo), Department of Immunology, FMVZ-UANL, Campus de Ciencias Agropecuarias, General Escobedo, Nuevo León, Mexico.
[Ti] Título:Histochemical study of Encephalitozoon cuniculi spores in the kidneys of naturally infected New Zealand rabbits.
[So] Source:J Vet Diagn Invest;29(3):269-277, 2017 May.
[Is] ISSN:1943-4936
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Encephalitozoon cuniculi is an important microsporidian pathogen that is considered an emergent, zoonotic, and opportunistic. It infects both domestic and laboratory rabbits, generating severe chronic interstitial and granulomatous nephritis with fibrosis and granulomatous encephalitis. Encephalitozoonosis is diagnosed in paraffin-embedded sections by examining the spores in the host tissues. The spores are difficult to observe when the samples are stained with hematoxylin and eosin (H&E), particularly when there is an inflammatory reaction and tissue damage. The spores are easily mistaken for other microorganisms, such as fungi (yeasts), protozoa, and bacteria. In our study, we used kidney samples from E. cuniculi-positive rabbits and employed 14 recommended histologic stains for detecting microsporidia spores: alcian blue, calcofluor white, Giemsa, Gram, Grocott, H&E, Luna, Luxol fast blue, Masson trichrome, modified trichrome stain (MTS), periodic acid-Schiff reaction (PAS), Van Gieson, Warthin-Starry (WS), and Ziehl-Neelsen (ZN).We concluded that MTS and Gram stain, detected by light microscopy, and calcofluor white stain, detected by ultraviolet light microscopy, are the best stains for detecting spores of E. cuniculi in paraffin-embedded tissues from infected rabbits. These stains were superior to WS, ZN, Giemsa, and PAS for identifying spores without background "noise" or monochromatic interference. Also, they allow individual spores to be discerned in paraffin-embedded tissues. MTS allows observation of the polar tube, polaroplast, and posterior vacuole, the most distinctive parts of the spore.
[Mh] Termos MeSH primário: Encephalitozoon cuniculi/isolamento & purificação
Encefalitozoonose/veterinária
Doenças dos Roedores/diagnóstico
Esporos Fúngicos/isolamento & purificação
[Mh] Termos MeSH secundário: Animais
Animais Domésticos
Encefalitozoonose/diagnóstico
Encefalitozoonose/parasitologia
Rim/parasitologia
Coelhos
Doenças dos Roedores/parasitologia
Coloração e Rotulagem/veterinária
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170713
[Lr] Data última revisão:
170713
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170217
[St] Status:MEDLINE
[do] DOI:10.1177/1040638716668559


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[PMID]:28131379
[Au] Autor:Maestrini G; Ricci E; Cantile C; Mannella R; Mancianti F; Paci G; D'Ascenzi C; Perrucci S
[Ad] Endereço:Dipartimento di Scienze Veterinarie, Università di Pisa, Viale delle Piagge, 2- 56124 Pisa Italy. Electronic address: giomaes84@gmail.com.
[Ti] Título:Encephalitozoon cuniculi in rabbits: Serological screening and histopathological findings.
[So] Source:Comp Immunol Microbiol Infect Dis;50:54-57, 2017 Feb.
[Is] ISSN:1878-1667
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Serological prevalence of E. cuniculi infection was assessed in 183 rabbits from central Italy. In seropositive deceased rabbits, histopathological lesions were also evaluated. Sera from 118 rabbits from 6 intensive farms, 10 rabbits from 6 family farms, 16 rabbits from a zoo, 30 rabbits from 5 research laboratories and 9 pet rabbits from 9 different owners, were tested by an enzyme-linked immunosorbent assay. Data were statistically analysed. Tissue samples from brain and kidney of 10 deceased rabbits were formalin-fixed and subsequently analysed by histopathology and immunohistochemistry. Anti-E. cuniculi antibodies were found in 129/183 (70.5%) analysed sera. At statistical analysis, E. cuniculi seropositivity was significantly higher (p<0.05) in industrial and zoo rabbits. At histology, different degrees of pathological lesions were found in serological positive (9) deceased animals. In three rabbits deceased after showing neurological signs, the severity of the lesions was interpreted as a likely cause for their death.
[Mh] Termos MeSH primário: Encephalitozoon cuniculi/imunologia
Encefalitozoonose/veterinária
Infecções Protozoárias em Animais/imunologia
Coelhos/parasitologia
[Mh] Termos MeSH secundário: Animais
Animais Domésticos/parasitologia
Animais de Zoológico/parasitologia
Encéfalo/parasitologia
Encéfalo/patologia
Encephalitozoon cuniculi/isolamento & purificação
Encefalitozoonose/epidemiologia
Encefalitozoonose/parasitologia
Ensaio de Imunoadsorção Enzimática
Imuno-Histoquímica
Itália/epidemiologia
Rim/parasitologia
Rim/patologia
Animais de Estimação/parasitologia
Infecções Protozoárias em Animais/mortalidade
Infecções Protozoárias em Animais/fisiopatologia
Estudos Soroepidemiológicos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170217
[Lr] Data última revisão:
170217
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170130
[St] Status:MEDLINE


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[PMID]:27966020
[Au] Autor:Desoubeaux G; Pantin A; Peschke R; Joachim A; Cray C
[Ad] Endereço:Division of Comparative Pathology, Department of Pathology and Laboratory Medicine, Miller School of Medicine, University of Miami, Miami, FL, 33136, USA. gvd10@miami.edu.
[Ti] Título:Application of Western blot analysis for the diagnosis of Encephalitozoon cuniculi infection in rabbits: example of a quantitative approach.
[So] Source:Parasitol Res;116(2):743-750, 2017 Feb.
[Is] ISSN:1432-1955
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Diagnosis of Encephalitozoon cuniculi infection in rabbits remains a major veterinary issue. ELISA or immunofluorescence assays are the current reference standards of serological tests. However, these conventional techniques suffer from a lack of accuracy for distinguishing active from past infections, as a positive serostatus is common in clinically normal rabbits. In this study, we assessed the diagnostic performance of Western blot (WB) to detect both anti-E. cuniculi immunoglobulin G (IgG) and immunoglobulin M (IgM) in comparison with ELISA and to address the intensity of the immune response through a quantitative approach. Positive WB results were highly correlated with the E. cuniculi-related diseased status (P < 0.0001). Although it was more labor intensive and less standardized, quantitative WB provided detailed comparable analysis regarding the humoral response and diagnostic performance similar to ELISA testing with statistically higher sensitivity (88.4 vs. 76.1% for IgG detection and 84.3 vs. 70.4% for IgM, P < 0.01). Several specific WB bands were shown to be significantly associated with concomitant clinical signs, like the one located at 50 kDa (OR = 8.2, [2.4-27.7], P = 0.0008) for IgG and (OR = 27.9, [4.2-187.9], P = 0.0006) for IgM. Therefore, the quantitative WB may have application in veterinary diagnostic laboratories to increase the accuracy of the clinical diagnosis of E. cuniculi infection. In addition, this tool may help to further understand the development and function of the humoral immune response to this infectious agent.
[Mh] Termos MeSH primário: Western Blotting/veterinária
Encephalitozoon cuniculi/imunologia
Encefalitozoonose/veterinária
Coelhos/microbiologia
[Mh] Termos MeSH secundário: Animais
Western Blotting/métodos
Encephalitozoon cuniculi/isolamento & purificação
Encefalitozoonose/diagnóstico
Encefalitozoonose/microbiologia
Ensaio de Imunoadsorção Enzimática/veterinária
Feminino
Técnica Direta de Fluorescência para Anticorpo/veterinária
Imunoglobulina G/sangue
Imunoglobulina M/sangue
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Immunoglobulin G); 0 (Immunoglobulin M)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171007
[Lr] Data última revisão:
171007
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161215
[St] Status:MEDLINE
[do] DOI:10.1007/s00436-016-5343-4


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[PMID]:26662038
[Au] Autor:Künzel F; Rebel-Bauder B; Kassl C; Leschnik M; Url A
[Ad] Endereço:1 Clinical Department of Small Animals and Horses, University of Veterinary Medicine, Vienna, Austria.
[Ti] Título:Meningoencephalitis in cats in Austria: a study of infectious causes, including Encephalitozoon cuniculi.
[So] Source:J Feline Med Surg;19(2):171-176, 2017 Feb.
[Is] ISSN:1532-2750
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Objectives Despite comprehensive diagnostics, the aetiology of meningoencephalitis (ME) in cats often remains undetermined. As a result of recently published surveys, Encephalitozoon cuniculi has gained growing importance in cats not only with ocular disorders, but also with central nervous system disease. Therefore, it was hypothesised that E cuniculi may be an underestimated pathogen in the development of feline non-suppurative and/or granulomatous ME. Methods As a first step, histopathological sections of the brain of cats with encephalopathy were retrospectively reviewed to identify cases of granulomatous ME. In a second step, an immunohistochemical screening for detection of E cuniculi was performed in cases with ME of unknown origin. Results In 59/89 (66.3%) cats with ME, an aetiologically relevant pathogen was detected. Forty-three of 89 (48.3%) cats had a diagnosis of feline infectious peritonitis. In 14/89 (15.7%) cats, protozoan cysts were identified and infection with Toxoplasma gondii was confirmed by immunohistochemistry (IHC) in all cases. In 2/89 (2.3%) cats with granulomatous ME, fungal organisms were identified. Thirty of 89 (33.7%) cats with ME of unknown origin that underwent IHC for the detection of E cuniculi remained negative. Conclusions and relevance The results of this study suggest that E cuniculi is unlikely to be directly associated with (non-suppurative and/or granulomatous) ME in cats in Austria.
[Mh] Termos MeSH primário: Doenças do Gato/microbiologia
Encephalitozoon cuniculi
Encefalitozoonose/veterinária
Meningoencefalite/veterinária
[Mh] Termos MeSH secundário: Animais
Áustria
Doenças do Gato/diagnóstico
Doenças do Gato/patologia
Gatos
Encefalitozoonose/diagnóstico
Encefalitozoonose/patologia
Meningoencefalite/diagnóstico
Estudos Retrospectivos
Toxoplasma
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170822
[Lr] Data última revisão:
170822
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151215
[St] Status:MEDLINE
[do] DOI:10.1177/1098612X15621352


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[PMID]:27385082
[Au] Autor:Schilliger L; Mentré V; Marschang RE; Nicolier A; Richter B
[Ad] Endereço:Dr. Lionel Schilliger, Clinique vétérinaire du village d'Auteuil, 75016 Paris, Frankreich, E-Mail: Dr.L.Schilliger@clinvet-auteuil.com.
[Ti] Título:Triple infection with agamid adenovirus 1, Encephaliton cuniculi-like microsporidium and enteric coccidia in a bearded dragon (Pogona vitticeps).
[Ti] Título:Dreifachinfektion mit Agamid-Adenovirus 1, einem Encephalitozoon-cuniculi-ähnlichen Mikrosporidium und Darmkokzidien bei einer Bartagame (Pogona vitticeps)..
[So] Source:Tierarztl Prax Ausg K Kleintiere Heimtiere;44(5):355-358, 2016 Oct 12.
[Is] ISSN:1434-1239
[Cp] País de publicação:Germany
[La] Idioma:eng; ger
[Ab] Resumo:A 2-month-old juvenile central bearded dragon was presented for anorexia and cachexia. Another specimen from the same cage had died suddenly 2 weeks prior. Fecal analysis revealed a high quantity of Isospora amphiboluri and a few pinworm eggs. Other examinations were not performed and the animal died a few days later despite supportive care. A third individual from the same cage presented with anorexia and a distended cœlom and was euthanized. In this third dragon, histological examination revealed intestinal coccidiosis, basophilic intranuclear inclusions compatible with adenovirus infection, acute hepatic necrosis with intrahepatocytic and intraenteritic organisms typical of microsporidia and renal gout. A PCR confirmed the diagnosis of adenovirosis. Sequencing showed that the PCR product was 100% identical to the corresponding portion of the agamid adenovirus 1 genome. A PCR for the detection of Encephalitozoon (E.) cuniculi was positive. Partial sequencing revealed 100% identity to an E. cuniculi-like organism previously found in bearded dragons. In cases where environmental factors such as poor hygiene or stress can be excluded, the presence of opportunistic pathogens in high numbers can be due to a systemic (viral) infection with temporary immunosuppression.
[Mh] Termos MeSH primário: Infecções por Adenoviridae/veterinária
Coccidiose/veterinária
Coinfecção/veterinária
Encefalitozoonose/veterinária
Lagartos
[Mh] Termos MeSH secundário: Adenoviridae/isolamento & purificação
Infecções por Adenoviridae/microbiologia
Infecções por Adenoviridae/parasitologia
Animais
Coccídios/isolamento & purificação
Coccidiose/microbiologia
Coccidiose/parasitologia
Coccidiose/virologia
Coinfecção/microbiologia
Coinfecção/parasitologia
Coinfecção/virologia
Encephalitozoon cuniculi/isolamento & purificação
Encefalitozoonose/microbiologia
Encefalitozoonose/parasitologia
Encefalitozoonose/virologia
Lagartos/microbiologia
Lagartos/parasitologia
Lagartos/virologia
Microsporídios
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170608
[Lr] Data última revisão:
170608
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160708
[St] Status:MEDLINE


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[PMID]:27320966
[Au] Autor:Tsukada R; Osaka Y; Takano T; Sasaki M; Inose M; Ikadai H
[Ad] Endereço:Laboratory of Veterinary Parasitology, School of Veterinary Medicine, Kitasato University, Towada, Aomori 034-8628, Japan.
[Ti] Título:Serological survey of Encephalitozoon cuniculi infection in cats in Japan.
[So] Source:J Vet Med Sci;78(10):1615-1617, 2016 Nov 01.
[Is] ISSN:1347-7439
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Antibodies to Encephalitozoon cuniculi (E. cuniculi) were examined by enzyme-linked immunosorbent assay using E. cuniculi PTP2 recombinant protein from serum samples that had been collected from a total of 295 cats in Japan. Of these samples, 6.1% (18/295) had antibodies against E. cuniculi, which included 6.3% (6/96) of the male cats and 6.0% (12/199) of the female cats. The incidence was slightly higher in feral cats (8.3%, 11/132) compared to domesticated cats (4.3%, 7/163). This suggests the possibility that the cats of our country have become a reservoir of E. cuniculi. This study is the first to demonstrate the prevalence of E. cuniculi infection in cats in Japan.
[Mh] Termos MeSH primário: Doenças do Gato/epidemiologia
Encephalitozoon cuniculi
Encefalitozoonose/veterinária
[Mh] Termos MeSH secundário: Animais
Anticorpos Antifúngicos/sangue
Doenças do Gato/microbiologia
Gatos
Reservatórios de Doenças/veterinária
Encefalitozoonose/epidemiologia
Ensaio de Imunoadsorção Enzimática/veterinária
Feminino
Japão/epidemiologia
Masculino
Estudos Soroepidemiológicos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Fungal)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170516
[Lr] Data última revisão:
170516
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160621
[St] Status:MEDLINE


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[PMID]:27156850
[Au] Autor:Rodríguez-Tovar LE; Castillo-Velázquez U; Arce-Mendoza AY; Nevárez-Garza AM; Zarate-Ramos JJ; Hernández-Vidal G; Rodríguez-Ramírez HG; Trejo-Chávez A
[Ad] Endereço:Cuerpo Académico de Zoonosis y Enfermedades Emergentes, Facultad de Medicina Veterinaria, UANL, General Escobedo, N. L., CP 66050, Mexico.
[Ti] Título:Interferon γ and interleukin 10 responses in immunocompetent and immunosuppressed New Zealand White rabbits naturally infected with Encephalitozoon cuniculi.
[So] Source:Dev Comp Immunol;62:82-8, 2016 09.
[Is] ISSN:1879-0089
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Levels of interferon (IFN)-γ and interleukin (IL)-10 were measured in the serum of immunocompetent and immunosuppressed New Zealand White rabbits naturally infected with Encephalitozoon cuniculi. IFN-γ levels were elevated in infected rabbits, and a synergic effect was observed in animals treated with the immunosuppressive agent dexamethasone (Dex). The role of IL-10 in infected rabbits remains unclear, as IL-10 levels were similar to those of negative controls. Dex appeared to exhibit a proinflammatory effect, as IFN-γ levels were elevated in infected immunosuppressed rabbits. Similarly, Dex exhibited a synergic effect in infected immunosuppressed rabbits, as evidenced by the elevation in IFN-γ production. These data indicate that the immune response to this glucocorticoid should be considered in the design of future animal model studies of immunosuppression.
[Mh] Termos MeSH primário: Dexametasona/administração & dosagem
Encephalitozoon cuniculi/imunologia
Encefalitozoonose/imunologia
Imunossupressores/administração & dosagem
Mediadores da Inflamação/metabolismo
Interferon gama/metabolismo
Coelhos/imunologia
[Mh] Termos MeSH secundário: Animais
Modelos Animais de Doenças
Imunocompetência
Hospedeiro Imunocomprometido
Interleucina-10/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Immunosuppressive Agents); 0 (Inflammation Mediators); 130068-27-8 (Interleukin-10); 7S5I7G3JQL (Dexamethasone); 82115-62-6 (Interferon-gamma)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171120
[Lr] Data última revisão:
171120
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160510
[St] Status:MEDLINE



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