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[PMID]:28918750
[Au] Autor:Song Z; Pan J; Xie L; Gong G; Han S; Zhang W; Hu Y
[Ad] Endereço:China State Institute of Pharmaceutical Industry, Zhangjiang Institute, Shanghai, 201203, China. bebydou@hotmail.com.
[Ti] Título:Expression, Purification, and Activity of ActhiS, a Thiazole Biosynthesis Enzyme from Acremonium chrysogenum.
[So] Source:Biochemistry (Mosc);82(7):852-860, 2017 Jul.
[Is] ISSN:1608-3040
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Thiamine pyrophosphate is an essential coenzyme in all organisms. Its biosynthesis involves independent syntheses of the precursors, pyrimidine and thiazole, which are then coupled. In our previous study with overexpressed and silent mutants of ActhiS (thiazole biosynthesis enzyme from Acremonium chrysogenum), we found that the enzyme level correlated with intracellular thiamine content in A. chrysogenum. However, the exact structure and function of ActhiS remain unclear. In this study, the enzyme-bound ligand was characterized as the ADP adduct of 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT) using HPLC and H NMR. The ligand-free ActhiS expressed in M9 minimal medium catalyzed conversion of NAD+ and glycine to ADT in the presence of iron. Furthermore, the C217 residue was identified as the sulfur donor for the thiazole moiety. These observations confirm that ActhiS is a thiazole biosynthesis enzyme in A. chrysogenum, and it serves as a sulfur source for the thiazole moiety.
[Mh] Termos MeSH primário: Acremonium/enzimologia
Proteínas Fúngicas/genética
Proteínas Fúngicas/metabolismo
Tiazóis/metabolismo
[Mh] Termos MeSH secundário: Difosfato de Adenosina/química
Difosfato de Adenosina/metabolismo
Sequência de Aminoácidos
Cromatografia Líquida de Alta Pressão
Proteínas Fúngicas/química
Proteínas Fúngicas/isolamento & purificação
Glicina/metabolismo
Ligantes
Espectroscopia de Ressonância Magnética
Espectrometria de Massas
Mutagênese Sítio-Dirigida
NAD/metabolismo
Proteínas Recombinantes/biossíntese
Proteínas Recombinantes/química
Proteínas Recombinantes/isolamento & purificação
Alinhamento de Sequência
Tiamina Pirofosfato/metabolismo
Tiazóis/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fungal Proteins); 0 (Ligands); 0 (Recombinant Proteins); 0 (Thiazoles); 0U46U6E8UK (NAD); 61D2G4IYVH (Adenosine Diphosphate); Q57971654Y (Thiamine Pyrophosphate); TE7660XO1C (Glycine)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170919
[St] Status:MEDLINE
[do] DOI:10.1134/S0006297917070112


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[PMID]:28686037
[Au] Autor:Artini M; Cicatiello P; Ricciardelli A; Papa R; Selan L; Dardano P; Tilotta M; Vrenna G; Tutino ML; Giardina P; Parrilli E
[Ad] Endereço:a Department of Public Health and Infectious Diseases , Sapienza University , Rome , Italy.
[Ti] Título:Hydrophobin coating prevents Staphylococcus epidermidis biofilm formation on different surfaces.
[So] Source:Biofouling;33(7):601-611, 2017 Aug.
[Is] ISSN:1029-2454
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Staphylococcus epidermidis is a significant nosocomial pathogen in predisposed hosts because of its capability of forming a biofilm on indwelling medical devices. The initial stage of biofilm formation has a key role in S. epidermidis abiotic surface colonization. Recently, many strategies have been developed to create new anti-biofilm surfaces able to control bacterial adhesion mechanisms. In this work, the self-assembled amphiphilic layers formed by two fungal hydrophobins (Vmh2 and Pac3) have proven to be able to reduce the biofilm formed by different strains of S. epidermidis on polystyrene surfaces. The reduction in the biofilm thickness on the coated surfaces and the preservation of cell vitality have been demonstrated through confocal laser scanning microscope analysis. Moreover, the anti-biofilm efficiency of the self-assembled layers on different medically relevant materials has also been demonstrated using a CDC biofilm reactor.
[Mh] Termos MeSH primário: Aderência Bacteriana/efeitos dos fármacos
Biofilmes/crescimento & desenvolvimento
Proteínas Fúngicas/química
Poliestirenos/química
Staphylococcus epidermidis/crescimento & desenvolvimento
[Mh] Termos MeSH secundário: Acremonium/química
Biofilmes/efeitos dos fármacos
Proteínas Fúngicas/isolamento & purificação
Proteínas Fúngicas/farmacologia
Interações Hidrofóbicas e Hidrofílicas
Viabilidade Microbiana/efeitos dos fármacos
Microscopia de Força Atômica
Microscopia Confocal
Pleurotus/química
Staphylococcus epidermidis/efeitos dos fármacos
Staphylococcus epidermidis/fisiologia
Propriedades de Superfície
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fungal Proteins); 0 (Polystyrenes)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170708
[St] Status:MEDLINE
[do] DOI:10.1080/08927014.2017.1338690


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[PMID]:28359302
[Au] Autor:Terfehr D; Dahlmann TA; Kück U
[Ad] Endereço:Lehrstuhl für Allgemeine und Molekulare Botanik, Ruhr-University Bochum, Universitätsstr. 150, Bochum, 44780, Germany.
[Ti] Título:Transcriptome analysis of the two unrelated fungal ß-lactam producers Acremonium chrysogenum and Penicillium chrysogenum: Velvet-regulated genes are major targets during conventional strain improvement programs.
[So] Source:BMC Genomics;18(1):272, 2017 03 31.
[Is] ISSN:1471-2164
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Cephalosporins and penicillins are the most frequently used ß-lactam antibiotics for the treatment of human infections worldwide. The main industrial producers of these antibiotics are Acremonium chrysogenum and Penicillium chrysogenum, two taxonomically unrelated fungi. Both were subjects of long-term strain development programs to reach economically relevant antibiotic titers. It is so far unknown, whether equivalent changes in gene expression lead to elevated antibiotic titers in production strains. RESULTS: Using the sequence of PcbC, a key enzyme of ß-lactam antibiotic biosynthesis, from eighteen different pro- and eukaryotic microorganisms, we have constructed a phylogenetic tree to demonstrate the distant relationship of both fungal producers. To address the question whether both fungi have undergone similar genetic adaptions, we have performed a comparative gene expression analysis of wild-type and production strains. We found that strain improvement is associated with the remodeling of the transcriptional landscape in both fungi. In P. chrysogenum, 748 genes showed differential expression, while 1572 genes from A. chrysogenum are differentially expressed in the industrial strain. Common in both fungi is the upregulation of genes belonging to primary and secondary metabolism, notably those involved in precursor supply for ß-lactam production. Other genes not essential for ß-lactam production are downregulated with a preference for those responsible for transport processes or biosynthesis of other secondary metabolites. Transcriptional regulation was shown to be an important parameter during strain improvement in different organisms. We therefore investigated deletion strains of the major transcriptional regulator velvet from both production strains. We identified 567 P. chrysogenum and 412 A. chrysogenum Velvet target genes. In both deletion strains, approximately 50% of all secondary metabolite cluster genes are differentially regulated, including ß-lactam biosynthesis genes. Most importantly, 35-57% of Velvet target genes are among those that showed differential expression in both improved industrial strains. CONCLUSIONS: The major finding of our comparative transcriptome analysis is that strain improvement programs in two unrelated fungal ß-lactam antibiotic producers alter the expression of target genes of Velvet, a global regulator of secondary metabolism. From these results, we conclude that regulatory alterations are crucial contributing factors for improved ß-lactam antibiotic titers during strain improvement in both fungi.
[Mh] Termos MeSH primário: Acremonium/genética
Perfilação da Expressão Gênica
Regulação Fúngica da Expressão Gênica
Genes Reguladores
Penicillium chrysogenum/genética
Transcriptoma
beta-Lactamases/genética
[Mh] Termos MeSH secundário: Acremonium/classificação
Metabolismo Energético/genética
Eucariotos/metabolismo
Rearranjo Gênico
Genoma Fúngico
Genômica/métodos
Sequenciamento de Nucleotídeos em Larga Escala
Penicillium chrysogenum/classificação
Filogenia
Metabolismo Secundário/genética
Virulência/genética
beta-Lactamas/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (beta-Lactams); EC 3.5.2.6 (beta-Lactamases)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171120
[Lr] Data última revisão:
171120
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170401
[St] Status:MEDLINE
[do] DOI:10.1186/s12864-017-3663-0


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[PMID]:28338628
[Au] Autor:Garson MJ; Hehre W; Pierens GK; Suciati
[Ad] Endereço:School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, QLD 4072, Australia. m.garson@uq.edu.au.
[Ti] Título:Revision of the Structure of Acremine P from a Marine-Derived Strain of Acremonium persicinum.
[So] Source:Molecules;22(4), 2017 Mar 24.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:The previously published structure of the fungal metabolite acremine P is revised by re-evaluation of chemical shift values and NOESY data, and by DFT calculations.
[Mh] Termos MeSH primário: Acremonium/química
Organismos Aquáticos/química
Terpenos/química
[Mh] Termos MeSH secundário: Vias Biossintéticas
Espectroscopia de Ressonância Magnética Nuclear de Carbono-13
Imagem Tridimensional
Estereoisomerismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Terpenes); 0 (acremine P)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170523
[Lr] Data última revisão:
170523
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170325
[St] Status:MEDLINE


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Silva, Maria do Rosário Rodrigues
Texto completo SciELO Brasil
[PMID]:28327806
[Au] Autor:Camplesi M; Silva HM; Arantes AM; Costa CR; Ataides FS; Silva TC; Reis MP; Silva MD
[Ad] Endereço:Departamento de Biomedicina, Universidade Paulista, Goiânia, GO, Brasil.
[Ti] Título:Invasive fungal infection in patients with hematologic disorders in a Brazilian tertiary care hospital.
[So] Source:Rev Soc Bras Med Trop;50(1):80-85, 2017 Jan-Feb.
[Is] ISSN:1678-9849
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION:: Invasive fungal infections (IFIs) are an important complication in immunocompromised individuals, particularly neutropenic patients with hematological malignancies. In this study, we aimed to verify the epidemiology and diagnosis of IFIs in patients with hematologic problems at a tertiary hospital in Goiânia-GO, Brazil. METHODS:: Data from 117 patients, involving 19 cases of IFIs, were collected. The collected data included diagnosis methods, demographics, clinical characteristics, and in vitro susceptibility to different antifungal agents. Among the 19 cases, 12 were classified as proven IFI and 7 as probable invasive aspergillosis with detection of galactomannan in blood and presence of lung infiltrates in radiographic images. Logistic regression analysis showed that the proven and probable IFIs were associated with increased risk of death. Statistical analysis demonstrated that age, sex, and underlying disease were not independently associated with risk of death in IFI patients. RESULTS:: Most bloodstream isolates of Candida spp. exhibited low minimum inhibitory concentrations (MICs) to all antifungal agents tested. Voriconazole and amphotericin had the lowest MICs for Aspergillus spp. and Fusarium spp., but Fusarium spp. showed the least susceptibility to all antifungals tested. Amphotericin B, fluconazole, and itraconazole were found to be inactive in vitro against Acremonium kiliense; but this fungus was sensitive to voriconazole. CONCLUSIONS:: Considering the high number of IFI cases, with crude mortality rate of 6%, we could conclude that IFIs remain a common infection in patients with hematological malignancies and underdiagnosed ante mortem. Thus, IFIs should be monitored closely.
[Mh] Termos MeSH primário: Doenças Hematológicas/microbiologia
Infecções Fúngicas Invasivas/microbiologia
[Mh] Termos MeSH secundário: Acremonium/efeitos dos fármacos
Acremonium/isolamento & purificação
Adulto
Antifúngicos/farmacologia
Aspergillus/efeitos dos fármacos
Aspergillus/isolamento & purificação
Candida/efeitos dos fármacos
Candida/isolamento & purificação
Feminino
Fusarium/efeitos dos fármacos
Fusarium/isolamento & purificação
Seres Humanos
Hospedeiro Imunocomprometido
Infecções Fúngicas Invasivas/diagnóstico
Masculino
Mananas/sangue
Testes de Sensibilidade Microbiana
Meia-Idade
Prevalência
Sensibilidade e Especificidade
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (Mannans); 11078-30-1 (galactomannan)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170503
[Lr] Data última revisão:
170503
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170323
[St] Status:MEDLINE


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[PMID]:28279173
[Au] Autor:Hotta F; Eguchi H; Nishimura K; Kogiso M; Ishimaru M; Kusaka S; Shimomura Y; Yaguchi T
[Ad] Endereço:Department of Ophthalmology, Sakai Hospital Kindai University, 2-7-1 Harayamadai, Minami-ku, Sakai, Osaka, 590-0132, Japan.
[Ti] Título:A super-infection in the cornea caused by Stemphylium, Acremonium, and α-Streptococcus.
[So] Source:Ann Clin Microbiol Antimicrob;16(1):11, 2017 Mar 09.
[Is] ISSN:1476-0711
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Polymicrobial keratitis with fungus and bacteria can lead to blindness and is challenging to treat. Here, we introduce a case of fungal keratitis caused by two different strains in addition to definite bacterial super-infection caused by an α-Streptococcus sp., and describe the importance of microscopic examination. CASE PRESENTATION: A 74-year-old woman, who had a past history of infection with leprosy, presented with conjunctival hyperaemia, pain, and corneal opacity in her right eye. Under the presumptive diagnosis of infectious keratitis, corneal scrapings were stained by various reagents and inoculated on several agar plates. Microscopic findings of the scrapings revealed fungi and a small number of Gram-positive cocci. Multiple anti-fungal therapies with levofloxacin ophthalmic solution were administered. Although empiric treatment was initially effective, keratitis recurred 10 days after its initiation. Repeated corneal scraping revealed an abundance of Gram-positive chain cocci and a small amount of fungi, resulting in the switching of an antibiotic medication from levofloxacin to moxifloxacin and cefmenoxime. Keratitis resolved gradually after the conversion. Stemphylium sp., Acremonium sp., and α-Streptococcus sp. were simultaneously isolated from the corneal scrapings. CONCLUSIONS: To the best of our knowledge, this is the first case of fungal keratitis caused by Stemphylium sp., and also the first case of super-infection in the cornea caused by two different fungi and one bacterium. Microscopic examination of the corneal scrapings was beneficial in rapid decision of changing to appropriate drug according to the dominancy of pathogenicity.
[Mh] Termos MeSH primário: Acremonium/crescimento & desenvolvimento
Coinfecção/diagnóstico
Infecções Oculares Fúngicas/diagnóstico
Ceratite/diagnóstico
Saccharomycetales/crescimento & desenvolvimento
Streptococcus/crescimento & desenvolvimento
[Mh] Termos MeSH secundário: Acremonium/efeitos dos fármacos
Acremonium/patogenicidade
Idoso
Anti-Infecciosos/uso terapêutico
Cefmenoxima/uso terapêutico
Coinfecção/tratamento farmacológico
Coinfecção/microbiologia
Coinfecção/patologia
Córnea/efeitos dos fármacos
Córnea/microbiologia
Córnea/patologia
Infecções Oculares Fúngicas/tratamento farmacológico
Infecções Oculares Fúngicas/microbiologia
Infecções Oculares Fúngicas/patologia
Feminino
Fluoroquinolonas/uso terapêutico
Seres Humanos
Ceratite/tratamento farmacológico
Ceratite/microbiologia
Ceratite/patologia
Levofloxacino/uso terapêutico
Saccharomycetales/efeitos dos fármacos
Saccharomycetales/patogenicidade
Streptococcus/efeitos dos fármacos
Streptococcus/patogenicidade
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Fluoroquinolones); 6GNT3Y5LMF (Levofloxacin); KBZ4844CXN (Cefmenoxime); U188XYD42P (moxifloxacin)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170317
[Lr] Data última revisão:
170317
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170311
[St] Status:MEDLINE
[do] DOI:10.1186/s12941-017-0187-z


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[PMID]:28107448
[Au] Autor:Yuan Y; Feng H; Wang L; Li Z; Shi Y; Zhao L; Feng Z; Zhu H
[Ad] Endereço:State Key Laboratory of Cotton Biology, Institute of Cotton Research of Chinese Academy of Agricultural Sciences, Anyang, Henan, P. R. China.
[Ti] Título:Potential of Endophytic Fungi Isolated from Cotton Roots for Biological Control against Verticillium Wilt Disease.
[So] Source:PLoS One;12(1):e0170557, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Verticillium wilt is a soil-borne disease, and severely limits the development of cotton production. To investigate the role of endophytic fungi on Verticillium wilt, CEF-818 (Penicillium simplicissimum), CEF-714 (Leptosphaeria sp.), CEF-642 (Talaromyces flavus.) and CEF-193 (Acremonium sp.) isolated from cotton roots were used to assess their effects against cotton wilt disease caused by a defoliating V. dahliae strain Vd080. In the greenhouse, all treatments significantly reduced disease incidence and disease index, with the control efficacy ranging from 26% (CEF-642) to 67% (CEF-818) at 25 days (d) after inoculation. In the disease nursery, compared to controls (with disease incidence of 33.8% and disease index of 31), CEF-818, CEF-193, CEF-714 and CEF-642 provided a protection effect of 69.5%, 69.2%, 54.6% and 45.7%, respectively. Especially, CEF-818 and CEF-714 still provided well protection against Verticillium wilt with 46.9% and 56.6% or 14.3% and 33.7% at the first peak of the disease in heavily infected field, respectively (in early July). These results indicated that these endophytes not only delayed but also reduced wilt symptoms on cotton. In the harvest, the available cotton bolls of plant treated with CEF-818 and CEF-714 increased to 13.1, and 12.2, respectively. And the seed cotton yield significantly increased after seed bacterization with CEF-818 (3442.04 kg/ha) compared to untreated control (3207.51 kg/ha) by 7.3%. Furtherly, CEF-818 and CET-714 treatment increased transcript levels for PAL, PPO, POD, which leads to the increase of cotton defense reactions. Our results indicate that seed treatment of cotton plants with CEF-818 and CET-714 can help in the biocontrol of V. dahliae and improve seed cotton yield in cotton fields. This study provided a better understanding of cotton-endophyte interactions which will aid in developing effective biocontrol agents for Verticillium wilt of cotton in futhre.
[Mh] Termos MeSH primário: Gossypium/microbiologia
Controle Biológico de Vetores/métodos
Doenças das Plantas/prevenção & controle
Raízes de Plantas/microbiologia
Verticillium/metabolismo
[Mh] Termos MeSH secundário: Acremonium/isolamento & purificação
Acremonium/metabolismo
Endófitos/isolamento & purificação
Endófitos/metabolismo
Penicillium/isolamento & purificação
Penicillium/metabolismo
RNA de Plantas/genética
Reação em Cadeia da Polimerase em Tempo Real
Talaromyces/isolamento & purificação
Talaromyces/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (RNA, Plant)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170823
[Lr] Data última revisão:
170823
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170121
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0170557


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[PMID]:27736007
[Au] Autor:Lee JH; Yoo HY; Yang X; Kim DS; Lee JH; Lee SK; Han SO; Kim SW
[Ad] Endereço:Department of Chemical and Biological Engineering, Korea University, Seoul, Korea.
[Ti] Título:Utilization of algal sugars and glycerol for enhanced cephalosporin C production by Acremonium chrysogenum M35.
[So] Source:Lett Appl Microbiol;64(1):66-72, 2017 Jan.
[Is] ISSN:1472-765X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In our previous study, glycerol was utilized as an additional carbon source for the production of cephalosporin C (CPC) by Acremonium chrysogenum M35. In this study, algal sugars extracted from the third-generation biomass were utilized in the CPC production for the first time. The CPC production improved about twofold when using the algal sugars as the carbon source. The complex medium including algal sugars and glycerol was utilized, and 7·3 g l CPC production was achieved in a 250-ml shaking flask. To determine the important variables for the CPC production, Plackett-Burman design was carried out and 6·18 g l of CPC was estimated under the numerically optimized conditions. Under the optimized conditions, the CPC production was performed in a 5-l scale bioreactor, affording CPC production at a rate of 7·1 g l . Moreover, 6·7 g l CPC was produced using crude glycerol as the substrate. SIGNIFICANCE AND IMPACT OF THE STUDY: Microalgae are the biomass containing various components, such as carbohydrates, lipids, and amino acids. In this study, carbon sources contained in microalgae were obtained by acid extraction, and cephalosporin C (CPC), a ß-lactam antibiotic intermediate, was produced by using Acremonium chrysogenum M35. In addition, the increase of CPC production was not distinct for A. chrysogenum M35 with algal sugars as the only carbon source; therefore, glycerol was added, increasing the CPC production. Thus, cheap residues such as algal sugars form microalgal and glycerol form biodiesel process could be used as the alternative sources for the production of various products.
[Mh] Termos MeSH primário: Acremonium/metabolismo
Reatores Biológicos/microbiologia
Cefalosporinas/biossíntese
Glicerol/metabolismo
Microalgas/metabolismo
[Mh] Termos MeSH secundário: Carbono/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cephalosporins); 3XIY7HJT5L (cephalosporin C); 7440-44-0 (Carbon); PDC6A3C0OX (Glycerol)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161014
[St] Status:MEDLINE
[do] DOI:10.1111/lam.12684


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[PMID]:27633747
[Au] Autor:Tian J; Lai D; Zhou L
[Ti] Título:Secondary Metabolites from Acremonium Fungi: Diverse Structures and Bioactivities.
[So] Source:Mini Rev Med Chem;17(7):603-632, 2017.
[Is] ISSN:1875-5607
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Acremonium fungi have been isolated from various sources, such as soil, plants, and marine organisms. METHOD: The species in Acremonium have been proved to be rich sources of novel and bioactive secondary metabolites. Up to now, 356 metabolites belonging to steroids (6 compounds), terpenoids (86), meroterpenoids (66), polyketides (89), alkaloids (28), peptides (75), and miscellaneous types (6) have been isolated from Acremonium fungi. These metabolites displayed a wide range of biological activities including antimicrobial, cytotoxic, antitumor, immunosuppressive, antioxidant, antiinflammatory, antimalarial, phytotoxic, tremorgenic, antiviral, neuritogenic, insecticidal and enzymesinhibiting activities. CONCLUSION: This review highlights the structures and bioactivities of the secondary metabolites from Acremonium fungi reported until July 2016.
[Mh] Termos MeSH primário: Acremonium/química
[Mh] Termos MeSH secundário: Acremonium/metabolismo
Animais
Anti-Infecciosos/química
Anti-Infecciosos/isolamento & purificação
Anti-Infecciosos/farmacologia
Anti-Inflamatórios não Esteroides/química
Anti-Inflamatórios não Esteroides/isolamento & purificação
Anti-Inflamatórios não Esteroides/farmacologia
Antimaláricos/química
Antimaláricos/isolamento & purificação
Antimaláricos/farmacologia
Antineoplásicos/química
Antineoplásicos/isolamento & purificação
Antineoplásicos/farmacologia
Antioxidantes/química
Antioxidantes/isolamento & purificação
Antioxidantes/farmacologia
Antivirais/química
Antivirais/isolamento & purificação
Antivirais/farmacologia
Inibidores Enzimáticos/química
Inibidores Enzimáticos/isolamento & purificação
Inibidores Enzimáticos/farmacologia
Seres Humanos
Inseticidas/química
Inseticidas/isolamento & purificação
Inseticidas/farmacologia
Estrutura Molecular
Metabolismo Secundário
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Anti-Inflammatory Agents, Non-Steroidal); 0 (Antimalarials); 0 (Antineoplastic Agents); 0 (Antioxidants); 0 (Antiviral Agents); 0 (Enzyme Inhibitors); 0 (Insecticides)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170822
[Lr] Data última revisão:
170822
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160917
[St] Status:MEDLINE
[do] DOI:10.2174/1389557516666160914194134


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[PMID]:27599768
[Au] Autor:Nakamura I; Yoshimura S; Masaki T; Takase S; Ohsumi K; Hashimoto M; Furukawa S; Fujie A
[Ad] Endereço:Drug Discovery Research, Astellas Pharma Inc., Ibaraki, Japan.
[Ti] Título:ASP2397: a novel antifungal agent produced by Acremonium persicinum MF-347833.
[So] Source:J Antibiot (Tokyo);70(1):45-51, 2017 Jan.
[Is] ISSN:0021-8820
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:The novel antifungal agent ASP2397 (Vical's compound ID VL-2397) is produced by the fungal strain MF-347833 that was isolated from Malaysian leaf litter and is identified here as an Acremonium species based on its morphology, physiological properties and 28S ribosomal DNA sequence. Because of its potential importance for producing novel antifungal agents, we determined the taxonomic and biologic properties of MF-347833. We show here that ASP2397 is a cyclic hexapeptide that chelates aluminum ion and is therefore similar to ferrichrome, a hydroxamate siderophore. However, ASP2397 differs structurally from licensed antifungal agents such as amphotericin B, triazoles and echinocandins. To understand the relationship between chemical structure and biological function, we isolated certain ASP2397 derivatives from the culture broth, and we further chemically converted the metal-free form to other derivatives.
[Mh] Termos MeSH primário: Acremonium/metabolismo
Antifúngicos/isolamento & purificação
Antifúngicos/farmacologia
Complexos de Coordenação/farmacologia
Peptídeos Cíclicos/farmacologia
[Mh] Termos MeSH secundário: Alumínio/química
Antifúngicos/química
Complexos de Coordenação/química
Complexos de Coordenação/isolamento & purificação
Ferricromo/farmacologia
Malásia
Peptídeos Cíclicos/química
Peptídeos Cíclicos/isolamento & purificação
RNA Ribossômico 28S/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (ASP2397); 0 (Antifungal Agents); 0 (Coordination Complexes); 0 (Peptides, Cyclic); 0 (RNA, Ribosomal, 28S); 15630-64-5 (Ferrichrome); CPD4NFA903 (Aluminum)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170428
[Lr] Data última revisão:
170428
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160908
[St] Status:MEDLINE
[do] DOI:10.1038/ja.2016.107



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